Bladder stimulator with anti-tumor function

Abstract

The bladder stimulator with the anti-tumor function comprises an air battery, a sensor and terminal equipment, the air battery is electrically connected with the sensor, the sensor is connected with the terminal equipment, the air battery comprises a base body, a compound positive electrode and a metal negative electrode, and the compound positive electrode and the metal negative electrode are correspondingly arranged in the base body. Pins are respectively formed at the tail ends of the compound positive electrode and the metal negative electrode, the sensors comprise a pressure sensor and a frequency modulation wavelength sensor, and the terminal equipment is used for receiving data of the pressure sensor and the frequency modulation wavelength sensor and controlling the pins of the air battery to be electrified. The device can automatically and accurately control urination of the bladder of a patient, and is convenient, reliable, long in service life, low in harm to organ tissues of the patient, non-toxic and friendly. Meanwhile, electrical stimulation has certain repairing capacity on nerves, and the situation that bladder contraction power is insufficient can be effectively treated.

Description

Technical Field

[0001] The invention relates to a bladder stimulator with anti-tumor function, belonging to the technical field of medical equipment. Background Art

[0002] Bladder cancer (BC) is one of the common tumors in the urinary system, and its incidence rate is increasing every year. In view of its high recurrence rate and multiplicity, more and more clinical studies on bladder cancer are being conducted. Existing treatment methods are mainly through transurethral bladder tumor resection surgery or drug treatment, but there is still a high recurrence rate of the disease and poor treatment effect after treatment, especially for patients with intermediate-risk cancer. In addition, bladder cancer can also cause urethral dysfunction in patients and cause difficulty urinating. For cases of difficulty urinating, catheter catheterization is mostly used, which not only has a short use cycle and frequent replacement, but also causes pain to the patient every time. Summary of the invention

[0003] The technical problems to be solved by the present invention include the following two points: 1) How to solve the problem of urination difficulties in patients with bladder cancer; 2) The problem of postoperative recurrence of bladder cancer.

[0004] In order to solve the above technical problems, the technical solution of the present invention is to provide a bladder stimulator with anti-tumor function, characterized in that it includes an air battery with full degradation performance, a sensor, and a terminal device, the air battery is electrically connected to the sensor, the sensor is connected to the terminal device, the air battery includes a matrix, a composite positive electrode and a metal negative electrode, the composite positive electrode and the metal negative electrode are correspondingly arranged in the matrix, and pins are formed on the ends of the composite positive electrode and the metal negative electrode respectively, the sensor includes a pressure sensor and a frequency modulation wavelength sensor, and the terminal device is used to receive data from the pressure and frequency modulation wavelength sensors, and control the pins of the air battery to be powered. The degradation products of the battery itself or the loaded drugs can have a local therapeutic effect around the tumor.

[0005] Preferably, the air battery further comprises a strain gauge, which is connected to the composite positive electrode and the metal negative electrode near the pin; the strain gauge is used to detect the degree of deformation of the composite positive electrode or the metal negative electrode terminal portion near the pin after implantation into the bladder detrusor.

[0006] Preferably, the air battery further comprises a control switch, which is connected to the composite positive electrode or the metal negative electrode near the pin, and is used to control the on and off of the terminal circuit of the composite positive electrode or the metal negative electrode.

[0007] Preferably, the substrate comprises a first substrate and a second substrate, the first substrate and the second substrate are bonded to each other up and down, and the composite positive electrode and the metal negative electrode are correspondingly arranged between the first substrate and the second substrate.

[0008] Preferably, the terminal device controls the pin of the air battery to obtain electricity, thereby electrically stimulating the detrusor muscle of the bladder; the pressure sensor is arranged in the bladder to detect the air pressure value inside the bladder, and the frequency modulation wavelength sensor adjusts the electrical signal transmitted by the pin externally.

[0009] Preferably, when the pressure sensor detects that the air pressure value inside the bladder reaches a preset threshold, the terminal device controls the air battery to discharge, contacts the bladder detrusor muscle through the pins and electrically stimulates the bladder detrusor muscle, thereby achieving automatic urination.

[0010] Preferably, the composite positive electrode and the metal negative electrode are both sheets, and the ends of the sheets are pins.

[0011] Preferably, the material of the matrix includes one of polylactic acid-glycolic acid copolymer, polylactic acid, polyglycolic acid, polycaprolactone or polyglycolic acid; the material of the composite positive electrode includes at least one of metal carbide, metal nitride, metal carbonitride, sodium ferrocyanide or potassium ferrocyanide; the material of the metal negative electrode and the pin includes one of magnesium alloy, zinc alloy, iron alloy and cobalt alloy.

[0012] Preferably, the lead comprises a substrate and an upper drug-carrying polymer, wherein the upper drug-carrying polymer comprises polylactic acid, polycaprolactone, polytrimethylene carbonate, polybutylene terephthalate-adipate, cellulose-based biodegradable material, polyglycolide, polydioxanone, and polyhydroxyalkanoate.

[0013] Preferably, the air battery can release hydrogen and / or drugs through electrolysis reaction during operation to disinfect tumor tissue inside the bladder.

[0014] Preferably, the drug includes one or more of cisplatin, gemcitabine, doxorubicin, mitoxantrone, carboplatin, and paxilamide.

[0015] Compared with the prior art, the present invention has at least one of the following beneficial effects:

[0016] The bladder stimulator with anti-tumor function according to the present invention can realize the automatic and accurate urination control of the patient's bladder, is convenient and reliable, has a long service life, and has very low damage to the patient's organs and tissues, and is non-toxic and friendly. In addition, the bladder stimulator of the present invention has a full degradation function, does not require a secondary operation to remove, and is low in cost, which can reduce the patient's medical burden. At the same time, electrical stimulation has a certain ability to repair nerves and can effectively treat insufficient bladder contraction power. In addition, when the air battery in the bladder stimulator is in operation, it can also release hydrogen and / or drugs through electrolysis reactions, which can conveniently and efficiently disinfect the tumor tissue inside the patient's bladder, while achieving the effects of anti-tumor and promoting bladder health recovery. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the use of a bladder stimulator with anti-tumor function;

[0018] Figure 2 Schematic diagram of the air battery structure. DETAILED DESCRIPTION

[0019] In order to make the present invention more clearly understood, preferred embodiments are described in detail below with reference to the accompanying drawings.

[0020] The present invention provides a bladder stimulator with anti-tumor function, such as Figure 1 As shown, it includes a sensor 10, an air battery 20 and a terminal device 30. The sensor 10 includes a pressure sensor and a frequency modulation wavelength sensor.

[0021] The air battery 20 is electrically connected to the sensor 10, such as Figure 2 As shown, the air battery 20 includes a substrate 21, a composite positive electrode 22, a metal negative electrode 23 and a strain gauge 25. The substrate 21 is used to carry the components of the air battery 20. The air battery 20 is used to power the sensor 10.

[0022] The composite positive electrode 22 and the metal negative electrode 23 are correspondingly arranged in the matrix 21 . Pins 24 are formed on the ends of the composite positive electrode 22 and the metal negative electrode 23 , respectively. The pins 24 are used to be implanted in the detrusor muscle 42 of the bladder.

[0023] The strain gauge 25 is connected to the composite positive electrode 22 or the metal negative electrode 23 near the pin 24. The strain gauge 25 is used to detect the deformation degree of the end portion of the composite positive electrode 22 or the metal negative electrode 23 near the pin 24 after implantation into the bladder detrusor 42, thereby protecting the composite positive electrode 22, the metal negative electrode 23 and the corresponding pin 24 from damage during implantation.

[0024] The terminal device 30 is used to receive data from the pressure and frequency modulation wavelength sensors, and control the pin 24 of the air battery 20 to electrically stimulate the bladder detrusor 42. The pressure sensor is used to be set in the bladder 40 to detect the air pressure value inside the bladder 40, and the frequency modulation wavelength sensor is externally adjusted to transmit the electrical signal from the pin.

[0025] Specifically, the bladder stimulator according to the embodiment of the present invention receives the data of the pressure sensor through the terminal device 30. When the pressure sensor detects that the air pressure value inside the bladder 40 reaches a preset threshold value (that is, the urine stored inside the bladder 40 reaches a preset amount), the terminal device 30 controls the air battery 20 to discharge, and contacts the bladder detrusor 42 through the pins 24 on the composite positive electrode 22 and the metal negative electrode 23 and electrically stimulates the bladder detrusor 42, thereby achieving automatic urination, which is convenient and reliable, has a long service life, and causes very little pain to the patient. At the same time, electrical stimulation has a certain ability to repair nerves and can effectively treat the situation of insufficient bladder contraction power.

[0026] In addition, the air battery 20 in the bladder stimulator according to the embodiment of the present invention is used to power the pressure sensor on the one hand, and on the other hand, the air battery 20 can release hydrogen through an electrolysis reaction during operation to disinfect the tumor tissue 41 inside the bladder 40, thereby achieving the effects of anti-tumor and promoting the healthy recovery of the bladder.

[0027] In addition, the bladder stimulator according to the embodiment of the present invention can also place corresponding drugs (including one or more of cisplatin, gemcitabine, doxorubicin, mitoxantrone, carboplatin, and pasiximab) on pin 24, and release the drugs through electrolysis to further improve the treatment recovery effect.

[0028] In some embodiments, Figure 2 As shown, the air battery 20 further includes a control switch 26 .

[0029] The control switch 26 is connected to the composite positive electrode 22 or the metal negative electrode 23 near the pin 24 , and the control switch 26 is used to control the on / off of the terminal circuit of the composite positive electrode 22 or the metal negative electrode 23 .

[0030] The pin 24 is energized by the control switch 26 to stimulate the detrusor muscle 42 of the bladder.

[0031] That is to say, the control switch 26 is in an open state under normal conditions. When the data transmitted by the pressure sensor received by the terminal device 30 reaches a predetermined value, the terminal device 30 sends a signal to the control switch 26 to close it. As a result, the composite positive electrode 22 and the metal negative electrode 23 of the air battery 20 are in an energized state, and then discharge through the pin 24 to stimulate the bladder detrusor muscle 42, thereby realizing the function of automatically controlling urination.

[0032] In some embodiments, Figure 2 As shown, the substrate 21 includes a first substrate and a second substrate, the first substrate and the second substrate are laminated up and down, and the composite positive electrode 22 and the metal negative electrode 23 are correspondingly arranged between the first substrate and the second substrate.

[0033] That is to say, the substrate 21 is respectively attached to the first substrate and the second substrate up and down, and then clamps and supports other components in the air battery 20 from both sides to achieve maximum protection.

[0034] The material of the substrate 21 includes one of polylactic acid-co-glycolic acid, polylactic acid, polyglycolic acid, polycaprolactone or polyglycolic acid.

[0035] Specifically, when the polylactic acid-glycolic acid copolymer material is selected, since both polylactic acid (PLA) and glycolic acid (PGA) are biocompatible materials, they can be used in vivo, reducing the body's rejection reaction; the copolymer can gradually degrade in the biological environment, reducing environmental pollution; and by adjusting the ratio of PLA and PGA, the release rate of the drug can be controlled and the drug delivery system can be optimized. In addition, the polylactic acid-glycolic acid copolymer has good mechanical strength and toughness, and can be processed by thermoplasticity, suitable for a variety of molding.

[0036] The selected polylactic acid material has the advantages of good thermal stability, biodegradability, good mechanical and physical properties and is conducive to processing and molding.

[0037] The selected polyglycolic acid and polycaprolactone materials have good biodegradability and biocompatibility. After a certain use cycle, they will automatically decompose into carbon dioxide and water that are harmless to the human body.

[0038] In addition, the base body 21 of the embodiment of the present invention is made of degradable material, which solves the adhesion problem caused by surgical removal and prolonged implantation.

[0039] The thickness of the first substrate and the second substrate is 0.1-0.2 cm.

[0040] Therefore, the material consumption of the base body 21 is small, which reduces the material cost, and at the same time has good mechanical properties.

[0041] In some embodiments, Figure 2 As shown, the composite positive electrode 22 and the metal negative electrode 23 are both formed into sheets, and a lead 24 is formed at the end of the sheet.

[0042] Therefore, the composite positive electrode 22 and the metal negative electrode 23 as a whole have a large specific surface area, which helps to improve the energy storage performance of the material, as well as the rate and efficiency of the electrochemical reaction, and have good mechanical properties when supported inside the matrix 21.

[0043] As a result, the discharge efficiency of the air battery 20 can be greatly ensured, and the battery performance can be improved.

[0044] The material of the composite positive electrode 22 may include one or more of metal carbides, metal nitrides, metal carbonitrides, sodium ferrocyanide, or potassium ferrocyanide.

[0045] The metal carbide, metal nitride or metal carbonitride material used as the composite positive electrode 22 has high electrical conductivity, good strength and toughness. In particular, the chemical composition and surface chemical properties of these materials can be adjusted through chemical doping and surface modification to give the materials different functions, which can greatly improve the applicability of the composite positive electrode 22.

[0046] Sodium ferrocyanide or potassium ferrocyanide is selected as the composite positive electrode 22, which has a high electrical conductivity, so that it can effectively conduct current when used as a cathode material in batteries and supercapacitors. The raw materials of sodium ferrocyanide or potassium ferrocyanide are relatively non-toxic and have good energy storage capacity, and have good chemical stability, and can maintain performance in multiple charge and discharge cycles.

[0047] The material of the metal negative electrode 23 and the pin 24 may include one of a magnesium alloy, a zinc alloy, an iron alloy, and a cobalt alloy.

[0048] Specifically, the material containing degradable metal is selected as the metal negative electrode 23 and the pin 24, and its chemical properties are stable, so that it is not easy to have thermal runaway when overcharged or short-circuited. Metal-based air batteries have a higher energy density and can store more energy, and the migration rate of metal ions in the battery is faster, which helps to improve the charging and discharging efficiency of the battery. In addition, these alloys can degrade by themselves after a certain period of time, and the degradation products are harmless to the human body.

[0049] In some embodiments, Figure 2 As shown, the pin 24 includes a base and an upper layer of drug-loaded polymer (the upper layer of drug-loaded polymer includes polylactic acid, polycaprolactone, polytrimethylene carbonate, polybutylene terephthalate-adipate, cellulose-based biodegradable materials, polyglycolide, polydioxanone, and polyhydroxyalkanoate). Therefore, when the pin 24 is implanted in the bladder detrusor muscle 42, the connection is stable and reliable, and it is not easy to cause pain or damage to the human body.

[0050] The length of the substrate is 0.5-1 cm, the width is 0.5-1 cm, and the thickness is 0.1-0.2 cm.

[0051] The pin 24 has a bottom diameter of 0.05-0.1 cm and a height of 0.2-0.3 cm.

[0052] It should be noted here that the specifications of the air battery 20 in the bladder stimulator according to the embodiment of the present invention are 2cm×3cm×0.6cm, the electrical stimulation intensity of the released current is 6-20mA, the degradation period of each material in the air battery 20 is 3-6 months, and the service life is relatively long.

[0053] in,

[0054] Biocompatible materials: Magnesium is a biocompatible metal that is able to gradually degrade in the body without causing significant adverse reactions. This makes it very suitable for implantable biomedical devices.

[0055] Degradability: The self-degrading properties of magnesium, zinc, iron and cobalt mean that the stimulator will naturally break down after it has served its therapeutic purpose, thus avoiding the need for a secondary surgery to remove the device.

[0056] Electrical stimulation: The device may generate electrical stimulation by controlling the electrochemical reaction of magnesium. Oxidation reactions occur in body fluids, which can release electrical charges suitable for microcurrent stimulation to activate or regulate nerves or muscles in the bladder.

[0057] Microelectrode design: Magnesium-based stimulators may be embedded with microelectrodes, which can be used to precisely locate and stimulate specific nerves in the bladder.

[0058] Signal conditioning and control: To achieve effective control of bladder function, the stimulator may need to integrate electronic components to adjust the stimulation frequency and intensity.

[0059] The use process of the present invention is as follows:

[0060] After open surgery, the stimulator is implanted in the body, which has the functions of electrical stimulation catheterization and in situ prevention of tumor recurrence.

Claims

1. A bladder stimulator with anti-tumor function, characterized in that: The invention comprises an air battery (20) with full degradation performance, a sensor (10), and a terminal device (30). The air battery (20) is electrically connected to the sensor (10), and the sensor (10) is connected to the terminal device (30). The air battery (20) comprises a substrate (21), a composite positive electrode (22), and a metal negative electrode (23). The composite positive electrode (22) and the metal negative electrode (23) are correspondingly arranged in the substrate (21). Pins (24) are respectively formed on the ends of the composite positive electrode (22) and the metal negative electrode (23). The sensor (10) comprises a pressure sensor and a frequency modulation wavelength sensor. The terminal device (30) is used to receive data from the sensor (10) and control the pin (24) of the air battery (20) to obtain electricity.

2. A bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The air battery (20) further comprises a strain gauge (25), which is connected to the composite positive electrode (22) and the metal negative electrode (23) near the pin (24); the strain gauge (25) is used to detect the degree of deformation of the end portion of the composite positive electrode (22) or the metal negative electrode (23) near the pin (24) after being implanted in the bladder detrusor muscle (42).

3. A bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The air battery (20) further comprises a control switch (26), which is connected to the composite positive electrode (22) or the metal negative electrode (23) near the pin (24), and the control switch (26) is used to control the on and off of the terminal circuit of the composite positive electrode (22) or the metal negative electrode (23).

4. A bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The substrate (21) comprises a first substrate and a second substrate, the first substrate and the second substrate are bonded together, and the composite positive electrode (22) and the metal negative electrode (23) are correspondingly arranged between the first substrate and the second substrate.

5. The bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The terminal device (30) controls the pin (24) of the air battery (20) to obtain electricity, thereby electrically stimulating the bladder detrusor muscle (42); the pressure sensor is arranged in the bladder (40) to detect the air pressure value inside the bladder (40); the frequency modulation wavelength sensor adjusts the electrical signal transmitted by the pin externally.

6. A bladder stimulator with anti-tumor function as claimed in claim 5, characterized in that: When the pressure sensor detects that the air pressure value inside the bladder (40) reaches a preset threshold, the terminal device (30) controls the air battery (20) to discharge, contacts the bladder detrusor muscle (42) through the pin (24) and energizes to stimulate the bladder detrusor muscle (42), thereby achieving automatic urination.

7. The bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The composite positive electrode (22) and the metal negative electrode (23) are both sheets, and the ends of the sheets are pins (24).

8. The bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The material of the matrix (21) includes one of polylactic acid-glycolic acid copolymer, polylactic acid, polyglycolic acid, polycaprolactone or polyglycolic acid; the material of the composite positive electrode (22) includes at least one of metal carbide, metal nitride, metal carbonitride, sodium ferrocyanide or potassium ferrocyanide; the material of the metal negative electrode (23) and the pin (24) includes one of magnesium alloy, zinc alloy, iron alloy and cobalt alloy.

9. The bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The pin (24) comprises a substrate and an upper layer of drug-carrying polymer.

10. The bladder stimulator with anti-tumor function as claimed in claim 1, characterized in that: The air battery (20) can release hydrogen and / or drugs through electrolysis reaction when in operation, thereby disinfecting tumor tissue (41) inside the bladder (40).

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