Non-invasive blood glucose detection device and manufacturing method thereof

Abstract

The invention provides a non-invasive blood glucose detection device and a manufacturing method thereof. The manufacturing method comprises the following steps: providing a substrate; an injection molding process or an electroplating process is executed to form at least one light blocking wall on the substrate, each light blocking wall comprises a lower step structure and an upper step structure, the lower step structures are connected with the substrate, and the upper step structures are connected with the lower step structures; arranging a light-emitting element and a light-receiving element on the substrate, wherein the light-emitting element and the light-receiving element are separated by at least one light blocking wall; forming a packaging structure for packaging the light-emitting element and the light-receiving element on the substrate; and arranging a transparent cover plate on the packaging structure and the at least one light blocking wall, and limiting the arrangement height of the transparent cover plate through the at least one light blocking wall. The manufacturing process can be effectively simplified, the width of the light blocking wall can be effectively reduced, each light blocking wall can provide supporting and limiting effects for the transparent cover plate, the light blocking walls can improve the uniformity of internal materials and reduce generation of bubbles, and then the high light reflectivity and the low light penetration rate of the light blocking walls are kept.

Description

Technical Field

[0001] The present invention relates to a non-invasive blood sugar detection device and a manufacturing method thereof, and in particular to a non-invasive blood sugar detection device and a manufacturing method thereof which improves the existing glue dispensing method to form a light-blocking wall. Background Art

[0002] In the manufacturing process of the existing non-invasive blood glucose detection device, the light-emitting elements and light-receiving elements on the substrate are first packaged using packaging materials, and a cover plate is set on the packaging material. Then, grooves are formed by half-cutting at appropriate positions of the cover plate and the packaging material (for example, between the light-emitting elements and the light-receiving elements and / or around the light-emitting elements and the light-receiving elements). Finally, the grooves are filled with opaque glue by dispensing, and the required light-blocking wall is formed after curing.

[0003] However, since the existing manufacturing process for forming the light-blocking wall is relatively complicated, it can only cope with the manufacturing process of devices with smaller areas, which increases the manufacturing cost and may affect the manufacturing accuracy. Furthermore, during the half-cutting process of the cover plate and the packaging material, the width of the formed light-blocking wall is greater than 200μm and difficult to reduce due to the size of the cutting tool. In addition, the light-blocking wall formed by dispensing is prone to uncontrolled uniformity or the presence of some bubbles, which leads to a decrease in the light-blocking rate of the light-blocking wall and affects the accuracy of blood sugar testing.

[0004] Therefore, how to design a manufacturing method of a non-invasive blood glucose detection device that can improve the above-mentioned problems is indeed a topic worth studying. Summary of the invention

[0005] The object of the present invention is to provide a method for manufacturing a non-invasive blood glucose detection device which improves the existing method of forming a light-blocking wall by glue dispensing.

[0006] Another object of the present invention is to provide a method for manufacturing a non-invasive blood glucose detection device that can provide a limiting effect of a transparent cover.

[0007] To achieve the above-mentioned purpose, the manufacturing method of the non-invasive blood glucose detection device of the present invention includes the following steps: providing a substrate; performing an injection molding process or an electroplating process to form at least one light blocking wall on the substrate, wherein each light blocking wall includes a lower-step structure and an upper-step structure, the lower-step structure is connected to the substrate, and the upper-step structure is connected to the lower-step structure; arranging light-emitting elements and light-receiving elements on the substrate, wherein the light-emitting elements and the light-receiving elements are separated by at least one light blocking wall; forming a packaging structure for encapsulating the light-emitting elements and the light-receiving elements on the substrate; and arranging a transparent cover plate on the packaging structure and at least one light blocking wall, and limiting the setting height of the transparent cover plate by at least one light blocking wall.

[0008] In one embodiment of the present invention, the at least one light-blocking wall is made of a thermoplastic polymer material by an injection molding process.

[0009] In one embodiment of the present invention, the electroplating process uses metal or alloy material to form at least one light blocking wall.

[0010] In one embodiment of the present invention, the width of the lower-step structure is greater than the width of the upper-step structure.

[0011] In one embodiment of the present invention, the width of the lower step structure is 2 to 3 times the width of the upper step structure.

[0012] In one embodiment of the present invention, the width of the lower step structure is between 100 μm and 300 μm, and the width of the upper step structure is between 50 μm and 100 μm.

[0013] In one embodiment of the present invention, the height of the upper step structure is equal to the thickness of the transparent cover plate.

[0014] In one embodiment of the present invention, the packaging structure and the lower-step structure have the same height.

[0015] In one embodiment of the present invention, each light-blocking wall forms a three-dimensional structure in a stage shape through an upper-step structure and a lower-step structure.

[0016] In one embodiment of the present invention, the light transmittance of each light blocking wall is not greater than 5%, and the light reflectivity of each light blocking wall is not less than 95%.

[0017] The present invention also includes a non-invasive blood glucose detection device. The non-invasive blood glucose detection device includes a substrate, at least one light-blocking wall, a light-emitting element, a light-receiving element, a packaging structure and a transparent cover. Each light-blocking wall includes a lower-step structure and an upper-step structure, the lower-step structure is connected to the substrate, and the upper-step structure is connected to the lower-step structure. The light-emitting element and the light-receiving element are both arranged on the substrate, wherein the light-emitting element and the light-receiving element are separated by at least one light-blocking wall. The packaging structure is arranged on the substrate, and the packaging structure encapsulates the light-emitting element and the light-receiving element. The transparent cover is arranged on the packaging structure and at least one light-blocking wall, and the setting height of the transparent cover is limited by at least one light-blocking wall.

[0018] In one embodiment of the present invention, at least one light blocking wall is directly formed on the substrate by performing an injection molding process or an electroplating process.

[0019] Compared to the existing non-invasive blood glucose detection device manufacturing method, which first performs a packaging process and then cooperates with cutting grooves and dispensing to form a light-blocking wall, the non-invasive blood glucose detection device manufacturing method of the present invention first forms a light-blocking wall on the substrate through a three-dimensional molding process, and then performs the setting and packaging process of the light-emitting element and the light-receiving element, which can effectively simplify the manufacturing process and reduce the width of the light-blocking wall. Furthermore, by adopting a stage-like three-dimensional structure design for each light-blocking wall, a support and limiting effect can be provided for the transparent cover. In addition, the light-blocking wall formed by the non-invasive blood glucose detection device manufacturing method of the present invention can improve the uniformity of the internal material and reduce the generation of bubbles, thereby maintaining the high light reflectivity and low light transmittance of the light-blocking wall. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The present invention is a flowchart of a method for manufacturing a non-invasive blood glucose detection device.

[0021] Figure 2 It is a schematic diagram of the manufacturing structure corresponding to each step in the manufacturing method of the non-invasive blood glucose detection device of the present invention.

[0022] Figure 3 It is a schematic diagram of the non-invasive blood glucose detection device using the present invention.

[0023] Description of Reference Numerals

[0024] 1 Non-invasive blood glucose testing device

[0025] 10 substrate

[0026] 11 Page 1

[0027] 12 Side 2

[0028] 20 Light-blocking wall

[0029] 21 Lower level structure

[0030] 22 Superstructure

[0031] 30 Light-emitting element

[0032] 31. Welding wire

[0033] 40 light receiving element

[0034] 41 Welding wire

[0035] 50 Package Structure

[0036] 60 Transparent cover

[0037] 61 Coating

[0038] A1 First Space

[0039] A2 Second Space

[0040] Steps S1 to S5. DETAILED DESCRIPTION

[0041] Since the various schemes and embodiments are only illustrative and non-limiting, after reading this specification, those skilled in the art may also have other schemes and embodiments without departing from the scope of the present invention. According to the following detailed description and claims, the features and advantages of these embodiments will be more prominent.

[0042] In this document, "a" or "an" is used to describe the elements and components described herein. This is only for convenience of description and to provide a general meaning to the scope of the present invention. Therefore, unless it is obvious that it is intended otherwise, such description should be understood to include one or at least one, and the singular also includes the plural.

[0043] In this document, the terms "first" or "second" and the like are mainly used to distinguish or refer to the same or similar elements or structures, and do not necessarily imply the order of these elements or structures in space or time. It should be understood that in some cases or configurations, the ordinal numbers can be used interchangeably without affecting the implementation of the present invention.

[0044] As used herein, the terms "include", "have" or any other similar terms are intended to cover a non-exclusive inclusion. For example, an element or structure containing multiple elements is not limited to only those elements listed herein, but may include other elements that are not explicitly listed but are generally inherent to the element or structure.

[0045] Please refer to the following Figure 1 and Figure 2 ,in Figure 1 is a flow chart of a method for manufacturing a non-invasive blood glucose detection device of the present invention, Figure 2 The following is a schematic diagram of the structure of each step in the manufacturing method of the non-invasive blood glucose detection device of the present invention. Figure 1 and Figure 2 As shown, the manufacturing method of the non-invasive blood glucose detection device of the present invention comprises the following steps:

[0046] Step S1: providing a substrate.

[0047] First, the present invention provides a substrate 10 as a basic structural component of the non-invasive blood glucose detection device 1 of the present invention, which is used to carry other components of the non-invasive blood glucose detection device 1. The substrate 10 is a flat plate structure, and the substrate 10 includes a first surface 11 and a second surface 12 opposite to each other, and a conductive circuit is pre-set on the substrate 10. In the present invention, the substrate 10 can be a ceramic substrate, a silicon substrate or a PCB substrate, but the present invention is not limited thereto, and the substrate 10 can also be made of other materials.

[0048] Step S2: performing an injection molding process or an electroplating process to form at least one light-blocking wall on the substrate, wherein each light-blocking wall comprises a lower-step structure and an upper-step structure, the lower-step structure is connected to the substrate, and the upper-step structure is connected to the lower-step structure.

[0049] After providing the substrate 10 in the aforementioned step S1, the present invention can then perform an injection molding process or an electroplating process on the substrate 10 to directly form at least one light-blocking wall 20 with a three-dimensional structure on the first surface 11 of the substrate 10. The light-blocking wall 20 mainly provides the effect of blocking light, so the light-blocking wall 20 is made of a non-light-transmitting (including visible light and invisible light) material. In one embodiment of the present invention, if an injection molding process is performed, a thermoplastic polymer material is used to form the at least one light-blocking wall; the aforementioned thermoplastic polymer material includes polystyrene, low-density polyethylene, polyacetal or a polymer material with similar properties, but the present invention is not limited thereto. In another embodiment of the present invention, if an electroplating process is performed, a metal or alloy material is used to form the at least one light-blocking wall; the aforementioned metal includes zinc, copper, nickel or a metal material with similar properties, and the aforementioned alloy material includes zinc-nickel, bronze, brass or an alloy material with similar properties, but the present invention is not limited thereto. Through the aforementioned process and the material properties of the light-blocking wall, the light transmittance of each light-blocking wall 20 after molding is not greater than 5%, or the light reflectivity of each light-blocking wall 20 is not less than 95%, reaching a 100% light-blocking rate to provide a better light-blocking effect.

[0050] In the present invention, each light-blocking wall 20 formed includes a lower-step structure 21 and an upper-step structure 22. One end of the lower-step structure 21 is connected to the substrate 10, and the upper-step structure 22 is connected to the other end of the lower-step structure 21, so that each light-blocking wall 20 forms an overall three-dimensional structure similar to a stage through the lower-step structure 21 and the upper-step structure 22. That is to say, in the present invention, the width of the lower-step structure 21 of each light-blocking wall 20 is greater than the width of the upper-step structure 22; in another structural design, the width of the lower-step structure 21 of each light-blocking wall 20 can be 2 to 3 times the width of the upper-step structure 22. Accordingly, in addition to the light-blocking effect of each light-blocking wall 20 itself, the lower-step structure 21 can provide stable support for the light-blocking wall 20, and the upper-step structure 22 can further provide a light-blocking effect extending to the transparent cover plate 60; and the width difference between the lower-step structure 21 and the upper-step structure 22 can form a similar groove to provide a limiting effect for the transparent cover plate 60 set later. In addition, the height of the lower step structure 21 and the height of the upper step structure 22 can also be adjusted accordingly to match the packaging structure 50 and the transparent cover plate 60 that are subsequently arranged.

[0051] Before the injection molding process or the electroplating process is performed, the three-dimensional structural shape and size of each light-blocking wall 20 can be set first, so that when the corresponding process is performed, each light-blocking wall 20 is formed on the substrate 10 according to the set structural shape and the set size. In one embodiment of the present invention, the width of the lower step structure 21 of each light-blocking wall 20 is between 100 μm and 300 μm, and the width of the upper step structure 22 is between 50 μm and 100 μm. According to different design requirements, the height of each light-blocking wall 20 can also be changed.

[0052] In the present invention, the number and location of at least one light-blocking wall 20 can be changed according to different design requirements. For example, if there is only one light-blocking wall 20, the light-blocking wall 20 will be disposed between the light-emitting element 30 and the light-receiving element 40 to prevent the light emitted by the light-emitting element 30 from being directly received by the light-receiving element 40. If there are multiple light-blocking walls 20, the light-blocking walls 20 can be disposed around the light-emitting element 30 and the light-receiving element 40 to prevent the light outside the device from interfering with the light-receiving element 40 and the light-emitting element 30, and promote the concentrated emission or reception of light.

[0053] Step S3: Disposing a light emitting element and a light receiving element on the substrate, wherein the light emitting element and the light receiving element are separated by at least one light blocking wall.

[0054] After forming at least one light-blocking wall 20 in the aforementioned step S2, the present invention can then continue to set a light-emitting element 30 and a light-receiving element 40 on the first surface 11 of the substrate 10. The light-emitting element 30 mainly emits light of a specific wavelength band to irradiate the skin. In the present invention, the light-emitting element 30 can adopt a single LED light source, but the type, setting position and number of the light-emitting element 30 can be adjusted according to different design requirements. The light-emitting element 30 can be electrically connected to the substrate 10 through a welding wire 31. The light-receiving element 40 mainly receives light of a specific wavelength band that is transmitted back after diffuse reflection from the skin. In the present invention, the light-receiving element 40 can adopt a single photo sensor (Photo Detector), but the type, setting position and number of the light-receiving element 40 can be adjusted according to different design requirements. The light-receiving element 40 can be electrically connected to the substrate 10 through another welding wire 41. In terms of design, a certain distance is maintained between the light emitting element 30 and the light receiving element 40, and the light emitting element 30 and the light receiving element 40 are separated by at least one light blocking wall 20 to prevent the light receiving element 40 from directly receiving the light emitted by the light emitting element 30 and affecting the accuracy of the detection result.

[0055] Step S4: forming a packaging structure for packaging the light emitting element and the light receiving element on the substrate.

[0056] After the light-emitting element 30 and the light-receiving element 40 are arranged in the aforementioned step S3, the present invention can then form a packaging structure 50 for packaging the light-emitting element 30 and the light-receiving element 40 on the substrate 10. A packaging material is first applied to the first surface 11 of the substrate 10 so that the light-emitting element 30 and the light-receiving element 40 can be completely buried in the packaging material; then the applied packaging material is molded to form a packaging structure 50 for burying the light-emitting element 30 (which may also include the welding wire 31) and the light-receiving element 40 (which may also include the welding wire 41). The aforementioned packaging material used can be a transparent liquid optical glue or epoxy resin, but the present invention is not limited thereto. In one embodiment of the present invention, the height of the formed packaging structure 50 is greater than the height of the light-emitting element 30 and the light-receiving element 40, so as to reserve space for the setting of the welding wire 31 or 41. In addition, the packaging structure 50 has the same height as the lower step structure 21 of each light-blocking wall 20, so as to facilitate the subsequent setting of the transparent cover plate 60.

[0057] For example, in one embodiment of the present invention, there are multiple light-blocking walls 20, and the multiple light-blocking walls 20 form a first space A1 and a second space A2 isolated from each other on the substrate 10. The light-emitting element 30 is located in the first space A1, and the light-receiving element 40 is located in the second space A2. Therefore, the packaging material can be filled into the first space A1 and the second space A2 to form a packaging structure 50 in which the light-emitting element 30, the welding wire 31, the light-receiving element 40 and the welding wire 41 are buried.

[0058] Step S5: disposing a transparent cover plate on the packaging structure and at least one light-blocking wall, and limiting the installation height of the transparent cover plate by at least one light-blocking wall.

[0059] After the packaging structure 50 is formed in the aforementioned step S4, the present invention can set and fix a transparent cover plate 60 on the formed packaging structure 50 and at least one light blocking wall 20. The transparent cover plate 60 mainly provides a protective effect for other components in the non-invasive blood glucose detection device 1. The transparent cover plate 60 is made of transparent materials such as glass, but the present invention is not limited thereto. The transparent cover plate 60 can be fixed to the packaging structure 50 and at least one light blocking wall 20 by gluing. Since the packaging material forming the packaging structure 50 itself has an adhesive force, the transparent cover plate 60 can be adhesively fixed to the transparent cover plate 60 by the packaging material when the transparent cover plate 60 is set. In one embodiment of the present invention, the height of the upper step structure 22 is equal to the thickness of the transparent cover plate 60. Therefore, the groove formed by the width difference between the lower step structure 21 and the upper step structure 22 of each light blocking wall 20 can be used as a limiting structure for setting the transparent cover plate 60, so that the transparent cover plate 60 is kept at a set height position and will not press downward or contact the welding wire 31 or 41. For example, the thickness of the transparent cover 60 may be between 50 μm and 500 μm according to different designs, so the height of the upper step structure 22 of each light blocking wall 20 may also be adjusted to between 50 μm and 500 μm according to the thickness design of the transparent cover 60 , but the present invention is not limited thereto.

[0060] The transparent cover plate 60 further includes a coating 61, and the coating 61 is formed on the side of the transparent cover plate 60 facing away from the substrate 10. Through the arrangement of the coating 61, the transparent cover plate 60 can provide the effect of allowing light of a specific wavelength band to pass through, and can effectively block stray light of other unnecessary wavelength bands. Since the coating 61 is a structural design commonly used in existing cover plates, it will not be described in detail here.

[0061] The manufacturing method of the non-invasive blood glucose detection device of the present invention first forms at least one light-blocking wall 20 having a set three-dimensional structural shape and set size on the substrate 10 through an injection molding process or an electroplating process, and then performs the setting and packaging process of the light-emitting element 30 and the light-receiving element 40, and finally combines the transparent cover 60 and performs the cutting operation according to the design requirements to complete the manufacturing of the non-invasive blood glucose detection device 1 of the present invention. Compared with the existing non-invasive blood glucose detection device manufacturing method, the non-invasive blood glucose detection device manufacturing method of the present invention changes the process of first completing the component packaging to form the groove by half-cutting, and then forming the light-blocking wall by dispensing, so that the overall manufacturing process can be simplified and can cope with large-area manufacturing production (for example, the manufacturing area can be increased to more than 2 inches).

[0062] Furthermore, the manufacturing method of the non-invasive blood glucose detection device of the present invention can form at least one light-blocking wall 20 with a set size according to design requirements, and the width of each light-blocking wall 20 can be reduced to less than 100 μm, without being limited by the size of the cutting tool. Compared with the existing non-invasive blood glucose detection device manufacturing method, the width of each light-blocking wall 20 can be greatly reduced. In addition, the light-blocking wall 20 formed by the injection molding process or the electroplating process is not easy to generate bubbles during the process, and can effectively improve the uniformity of the material inside the light-blocking wall 20, thereby maintaining the high light reflectivity and low light transmittance of the light-blocking wall 20. In addition, the light-blocking wall 20 adopts a staged three-dimensional structure design, which can more effectively provide support and limiting effects for the transparent cover 60 to limit the setting height of the transparent cover 60. Accordingly, the non-invasive blood glucose detection device 1 of the present invention is able to miniaturize the overall structure and improve its application flexibility.

[0063] Please refer to Figures 1 to 3 ,in Figure 3 Schematic diagram of a non-invasive blood glucose detection device manufactured by the method for manufacturing a non-invasive blood glucose detection device of the present invention. Figures 1 to 3 As shown, the present invention also includes a non-invasive blood glucose detection device 1, and the non-invasive blood glucose detection device 1 can be manufactured using the aforementioned non-invasive blood glucose detection device manufacturing method. The non-invasive blood glucose detection device 1 of the present invention mainly includes a substrate 10, at least one light blocking wall 20, a light emitting element 30, a light receiving element 40, a packaging structure 50 and a transparent cover 60. Since the aforementioned structural elements and their functions have been described in the aforementioned content, they will not be repeated here.

[0064] The above embodiments are essentially only auxiliary explanations, and are not intended to limit the embodiments of the claims or the applications or uses of the embodiments. In addition, although at least one exemplary embodiment has been proposed in the aforementioned embodiments, it should be understood that the present invention can still have a large number of changes. It should also be understood that the embodiments described herein are not intended to limit the scope, use or configuration of the requested claims in any way. On the contrary, the aforementioned embodiments will provide a simple guide for those skilled in the art to implement one or more of the embodiments described. Furthermore, various changes can be made to the functions and arrangements of the components without departing from the scope defined by the claims, and the claims include known equivalents and all foreseeable equivalents at the time of filing the present patent application.

Claims

1. A method for manufacturing a non-invasive blood glucose detection device, comprising the following steps: providing a substrate; Performing an injection molding process or an electroplating process to form at least one light-blocking wall on the substrate, wherein each of the light-blocking walls includes a lower-step structure and an upper-step structure, the lower-step structure is connected to the substrate, and the upper-step structure is connected to the lower-step structure; A light emitting element and a light receiving element are arranged on the substrate, wherein the light emitting element and the light receiving element are separated by the at least one light blocking wall; Forming a packaging structure on the substrate to package the light emitting element and the light receiving element; and A transparent cover is disposed on the packaging structure and the at least one light-blocking wall, and the installation height of the transparent cover is limited by the at least one light-blocking wall.

2. The method for manufacturing a non-invasive blood glucose detection device as described in claim 1, wherein the injection molding process uses a thermoplastic polymer material to form the at least one light blocking wall.

3. The method for manufacturing a non-invasive blood glucose detection device as described in claim 1, wherein the electroplating process uses metal or alloy materials to form the at least one light blocking wall.

4. The method for manufacturing a non-invasive blood glucose detection device as described in claim 1, wherein the width of the lower step structure is greater than the width of the upper step structure.

5. The method for manufacturing a non-invasive blood glucose detection device as claimed in claim 4, wherein the width of the lower step structure is 2 to 3 times the width of the upper step structure. 6 . The method for manufacturing a non-invasive blood glucose detection device as claimed in claim 1 , wherein a width of the lower step structure is between 100 μm and 300 μm, and a width of the upper step structure is between 50 μm and 100 μm.

7. The method for manufacturing a non-invasive blood glucose detection device as described in claim 1, wherein the height of the upper step structure is equal to the thickness of the transparent cover.

8. The method for manufacturing a non-invasive blood glucose detection device as claimed in claim 1, wherein the packaging structure and the lower-step structure have the same height.

9. The method for manufacturing a non-invasive blood glucose detection device as described in claim 1, wherein each of the light-blocking walls forms a three-dimensional structure in a stage shape through the upper-step structure and the lower-step structure.

10. The method for manufacturing a non-invasive blood glucose detection device as claimed in claim 1, wherein the light transmittance of each light-blocking wall is not greater than 5% or the light reflectivity of each light-blocking wall is not less than 95%.

11. A non-invasive blood glucose detection device, comprising: a substrate; At least one light-blocking wall, each of the light-blocking walls comprises a lower-step structure and an upper-step structure, the lower-step structure is connected to the substrate, and the upper-step structure is connected to the lower-step structure; A light emitting element and a light receiving element are both disposed on the substrate, wherein the light emitting element and the light receiving element are separated by the at least one light blocking wall; a packaging structure, disposed on the substrate, the packaging structure packaging the light emitting element and the light receiving element; and A transparent cover plate is arranged on the packaging structure and the at least one light blocking wall, and the installation height of the transparent cover plate is limited by the at least one light blocking wall.

12. The non-invasive blood glucose detection device as claimed in claim 11, wherein the at least one light blocking wall is directly formed on the substrate by performing an injection molding process or an electroplating process.

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