Enteral nutritional agent

Abstract

The invention relates to the technical field of nutritional agents, and particularly discloses an enteral nutritional agent. The enteral nutritional agent comprises protein, saturated fat, unsaturated fat, carbohydrate, maltodextrin, corn starch, oligosaccharide, vitamin A, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, calcium, phosphorus, potassium, zinc, magnesium, iron, copper, manganese, selenium, glutamine, dietary fiber nucleotide, choline and the like. According to the invention, whey protein, casein and other high-quality proteins are used as main components, are rich in essential amino acids for human bodies, are high in bioavailability, can fully meet the requirement of mass loss of proteins caused by skin barrier damage of burn patients, and provide a key material basis for wound healing and body repair. Meanwhile, sufficient energy is provided for patients, and the risk of cardiovascular diseases is reduced. And various vitamins and minerals can promote epithelial tissue repair, resist oxidation and enhance immunity.

Description

Technical Field

[0001] The invention belongs to the technical field of nutrient preparations, and in particular relates to an enteral nutrient preparation. Background Art

[0002] Burns are a serious trauma that often triggers a series of complex physiological and pathological changes. Burn patients lose a lot of protein because their skin, an important barrier, is damaged. At the same time, the stress response and pain caused by burns often cause patients to have anorexia, further causing insufficient protein intake. This not only affects the normal healing of the wound, but also reduces the body's repair ability and increases the risk of complications such as infection.

[0003] At the same time, burn patients are in a high metabolic state, and their energy needs increase significantly. Reasonable energy supply is essential for maintaining the patient's physiological functions and promoting physical recovery. If the energy supply is insufficient, the body will consume its own protein to provide energy, aggravating the negative nitrogen balance and affecting tissue repair and immune function; unreasonable energy supply, such as an imbalance in the ratio of sugar and fat, may also cause metabolic disorders and other problems.

[0004] In terms of micronutrients, burn patients also have their own particular needs for vitamins and minerals. For example, vitamin A is essential for epithelial tissue repair and visual function maintenance. After burns, skin damage can be helped by vitamin A supplementation. Vitamin C, as an antioxidant, can promote collagen synthesis and enhance immunity, which is of great significance for burn wound healing. Minerals such as calcium, phosphorus, and potassium are indispensable for maintaining physiological functions such as bone health, nerve conduction, fluid balance, and normal heart rhythm. Due to traumatic stress and metabolic changes, burn patients may experience changes in the loss and demand for these minerals.

[0005] However, the enteral nutrition preparations currently available on the market often fail to fully consider the special nutritional needs of patients with burn anorexia. The types, contents and proportions of nutrients in some products cannot accurately match the physical conditions and rehabilitation needs of patients with burn anorexia, making it difficult to achieve ideal nutritional support effects. Therefore, the development of an enteral nutrition preparation specifically for patients with burn anorexia has important clinical significance and practical application value. Summary of the invention

[0006] The object of the present invention is to provide an enteral nutrition agent to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] An enteral nutrition agent comprises the following raw materials in percentage: protein: 15%-20%, fat: 15%-25%, carbohydrates 35%-55%, sugar: 5%-10%, vitamins 0.1%-0.2%, minerals 1.5%-2.5%, special nutrients 7%-9%, the protein includes but is not limited to whey protein and casein, the fat is saturated fat and unsaturated fat, the carbohydrates include but are not limited to maltodextrin and corn starch, the vitamins Vitamins include the following raw materials by weight: Vitamin A: 1500IU-2500IU / 100g, Vitamin C: 80mg-120mg / 100g, Vitamin E: 15mg-25mg / 100g, Vitamin B1: 1mg-2mg / 100g, Vitamin B2: 1.2mg-2.2mg / 100g, Vitamin B6: 1.5mg-2.5mg / 100g, Vitamin B12: 2μg-4μg / 100g, Acid: 15mg-25mg / 100g, folic acid: 200μg-400μg / 100g, the minerals include the following raw materials by weight, calcium: 600mg-800mg / 100g, phosphorus: 400mg-600mg / 100g; potassium: 500mg-700mg / 100g, zinc: 10mg-15mg / 100g, magnesium: 200mg-300mg / 100g, iron: 10mg-15mg / 100g, copper : 1mg-2mg / 100g, manganese: 1mg-2mg / 100g, selenium: 50μg-100μg / 100g: the special nutrients include glutamine, dietary fiber, arginine, ω-3 fatty acid ethyl ester and nucleotides, and the special nutrients account for the following percentages of the total raw materials: glutamine: 2%-5%, dietary fiber: 3%-8%, arginine: 1%-3%, ω-3 fatty acid ethyl ester: 1%-3%, nucleotides: 0.2%-0.5%. Choline: 0.5%-2%;

[0009] The energy includes protein, fat, carbohydrate and sugar, which is 444.5 kcal in total, and the pH value of the nutrient is between 6.0 and 7.0.

[0010] Preferably, the enteral nutrition agent comprises the following raw materials by weight: protein: 18 grams, saturated fat: 2 grams, unsaturated fat: 18 grams, carbohydrates: 45 grams, maltodextrin and corn starch: 40 grams, oligosaccharides: 5 grams

[0011] Vitamin A: 0.6mg (converted to 2000IU), vitamin C: 100mg, vitamin E: 20mg vitamin B1: 1.5mg, vitamin B2: 1.7mg, vitamin B6: 2mg, vitamin B12: 0.003mg (3μg), niacin: 20mg, folic acid: 0.3mg (300μg), calcium: 700mg phosphorus: 500mg, potassium: 600mg, zinc: 12.5mg, magnesium: 250mg, iron: 12.5mg, copper: 1.5mg manganese: 1.5mg, selenium: 0.075mg (75μg), glutamine: 3g, dietary fiber: 5g arginine: 2g, ω-3 fatty acid ethyl ester: 2g, nucleotides: 0.3g and choline: 1g.

[0012] Preferably, the casein is A2-β casein, and the ratio of whey protein to casein is 2:8-3:7.

[0013] Preferably, the unsaturated fat includes monounsaturated fat and polyunsaturated fat, and the ratio of saturated fat to unsaturated fat is 1:7-1:9.

[0014] Preferably, the ratio of maltodextrin to corn starch is 6:4, and the DE value of maltodextrin is 10-20.

[0015] Use of an enteral nutrition preparation in preparing enteral nutrition food for burn anorexia patients during treatment.

[0016] Preferably, for patients with anorexia due to burns, the target amount of protein administered is about 1.8 g / kg / d, and the target amount of non-protein calories administered is about 44.45 Kcal / kg / d, wherein the sugar-to-lipid ratio is 1.3:1.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention is mainly based on high-quality proteins such as whey protein and casein, and is rich in essential amino acids for the human body. It has high bioavailability and can fully meet the large-scale protein loss caused by damaged skin barrier in burn patients, as well as the problem of insufficient intake caused by anorexia, providing a key material basis for wound healing and body repair. At the same time, the fat formula not only provides sufficient energy for patients, but also reduces the risk of cardiovascular disease by controlling saturated fat intake. Oligosaccharides are used to regulate the balance of intestinal flora, promote intestinal health, meet the energy needs of burn anorexia patients and maintain intestinal microecology. And through multiple vitamins and minerals, it is crucial to maintain bone health, nerve conduction, muscle function, wound healing and the normal metabolism of multiple enzymes in the body in promoting epithelial tissue repair, anti-oxidation, enhancing immunity, participating in energy metabolism and cell division. At the same time, the total energy of this enteral nutrition preparation is about 444.5 kcal, which can provide suitable energy support for burn patients and meet their energy needs under high metabolic state. Reasonable pH value helps to reduce irritation to the gastrointestinal tract and improve patients' tolerance and absorption effect of nutritional preparations. DETAILED DESCRIPTION

[0019] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0020] Embodiment 1:

[0021] Enteral nutrition agent

[0022]

[0023]

[0024]

[0025] The corresponding

[0026] Patient condition: The patient was an adult female weighing 45 kg with mild burns covering 8% of the total area and anorexia.

[0027] Nutritional dosage: According to the target protein dosage of 1.8g / kg / d, the target non-protein calories dosage of 44.45Kcal / kg / d, the daily protein requirement is 81g, and the non-protein calories are 1999.25Kcal. This enteral nutrition contains 18g of protein per 100g, providing 444.5Kcal of energy, and the daily requirement is about 112.5g of this nutritional agent.

[0028] Specific usage: Take orally in 4-5 times, about 22-27.5g each time, with an interval of 3-4 hours.

[0029] Embodiment 2:

[0030] Enteral nutrition agent

[0031]

[0032]

[0033]

[0034] Patient condition: The patient was an adult male weighing 65 kg with moderate burns covering 25% of the area and anorexia.

[0035] Nutritional dosage: Daily protein requirement: 117g, non-protein calories: 2889.25Kcal. Daily requirement: about 162.5g of this nutritional supplement.

[0036] Specific usage: Use nasogastric feeding, infuse at a uniform speed in 5-6 times, about 26.7-32g each time, with an interval of 2-3 hours.

[0037] Embodiment three:

[0038] Enteral nutrition agent

[0039]

[0040]

[0041] Patient condition: The patient was an adult male weighing 80 kg, with severe burns, 40% burn area, and severe anorexia.

[0042] Nutritional dosage: 144g of protein and 3556Kcal of non-protein calories per day. About 200g of this nutritional supplement is needed per day.

[0043] Specific usage: Continuous infusion through nasogastric tube or gastroenterostomy, initial rate 20-30ml / h, gradually increase to 60-80ml / h, continuous infusion for 24 hours.

[0044] It will be appreciated that in the development of any actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will be a routine task of design, fabrication, and production for those of ordinary skill having the benefit of this disclosure without undue experimentation.

[0045] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. An enteral nutrition agent, characterized in that: The invention comprises the following raw materials in percentage: protein: 15%-20%, fat: 15%-25%, carbohydrate: 35%-55%, sugar: 5%-10%, vitamin: 0.1%-0.2%, mineral: 1.5%-2.5%, special nutrient: 7%-9%, the protein comprises but not limited to whey protein and casein, the fat comprises saturated fat and unsaturated fat, the carbohydrate comprises but not limited to maltodextrin and corn starch, the vitamin comprises the following raw materials in weight: vitamin A: 1500IU-2500IU / 100g, vitamin C: 80mg-120 mg / 100 g, vitamin E: 15mg-25mg / 100 g, vitamin B1: 1mg-2mg / 100 g, vitamin B2: 1.2mg-2.2mg / 100 g, vitamin B6: 1.5mg-2.5mg / 100 g, vitamin B12: 2μg-4μg / 100 g, niacin: 15mg-25mg / 100 g, folic acid: 200μg-400μg / 100 g, the minerals include the following raw materials by weight, calcium: 600mg-800mg / 100 g, phosphorus: 400mg-600mg / 100 g; Potassium: 500mg-700mg / 100g, zinc: 10mg-15mg / 100g, magnesium: 200mg-300mg / 100g, iron: 10mg-15mg / 100g, copper: 1mg-2mg / 100g, manganese: 1mg-2mg / 100g, selenium: 50μg-100μg / 100g: the special nutrients include glutamine, dietary fiber, arginine, ω-3 fatty acid ethyl ester and nucleotides, and the special nutrients account for the following percentages of the total raw materials: glutamine: 2%-5%, dietary fiber: 3%-8%, arginine: 1%-3%, ω-3 fatty acid ethyl ester: 1%-3%, nucleotides: 0.2%-0.5%. Choline: 0.5%-2%; The energy includes protein, fat, carbohydrate and sugar, which is 444.5 kcal in total, and the pH value of the nutrient is between 6.0 and 7.

0.

2. An enteral nutrition agent according to claim 1, characterized in that: Enteral nutrition includes the following raw materials by weight: protein: 18g, saturated fat: 2g, unsaturated fat: 18g, carbohydrates: 45g, maltodextrin and corn starch: 40g, oligosaccharides: 5g, vitamin A: 0.6mg (converted to 2000IU), vitamin C: 100mg, vitamin E: 20mg, vitamin B1: 1.5mg, vitamin B2: 1.7mg, vitamin B6: 2mg, vitamin B12: 0.003mg (converted to 3μg), niacin: 20mg, folic acid: 0.3mg (in 300μg), calcium: 700mg phosphorus: 500mg, potassium: 600mg, zinc: 12.5mg, magnesium: 250mg, iron: 12.5mg, copper: 1.5mg manganese: 1.5mg, selenium: 0.075mg (in 75μg), glutamine: 3g, dietary fiber: 5g arginine: 2g, ω-3 fatty acid ethyl ester: 2g, nucleotides: 0.3g and choline: 1g.

3. An enteral nutrition agent according to claim 1, characterized in that: The casein is A2-β casein, and the ratio of whey protein to casein is 2:8-3:

7.

4. An enteral nutrition agent according to claim 1, characterized in that: The unsaturated fat includes monounsaturated fat and polyunsaturated fat, and the ratio of saturated fat to unsaturated fat is 1:7-1:

9.

5. An enteral nutrition agent according to claim 1, characterized in that: The ratio of the maltodextrin to corn starch is 6:4, and the DE value of the maltodextrin is between 10 and 20.

6. Use of the enteral nutrition preparation according to any one of claims 1 to 5 in preparing enteral nutrition food for burn anorexia patients during treatment.

7. The use according to claim 6, characterized in that: For patients with anorexia due to burns, the target amount of protein is about 1.8g / kg / d, and the target amount of non-protein calories is about 44.45Kcal / kg / d, with a sugar-to-lipid ratio of 1.3:1.

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