Double-layer emulsion containing glycolipid

Abstract

The invention discloses a glycolipid-containing double-layer emulsion, which is prepared from the following raw material components in percentage by mass: 0.3 to 1.2 percent of glycolipid, 0.15 to 0.55 percent of emulsifier, 2 to 20 percent of grease, 0.5 to 2 percent of inorganic salt, a proper amount of pH regulator for regulating the pH value of a product to be greater than 5.5 and the balance of deionized water. The emulsifier comprises an oil-in-water emulsifier and a water-in-oil emulsifier. Glycolipid is selected to be compounded with a specific emulsifier, the upper layer of the prepared double-layer emulsion is a transparent oil phase, the lower layer of the prepared double-layer emulsion is a transparent water phase, the uniform white emulsion can be obtained through uniform shaking before use, and more visual experience is provided for consumers; the prepared double-layer emulsion is good in stability, and the addition of glycolipid also improves the anticorrosion efficiency and reduces the risk that the product is polluted by microorganisms.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to a double-layer emulsion containing glycolipid. Background Art

[0002] With the improvement of economic level, people's skin care awareness has gradually increased, and lotion has become an important product for consumers' daily skin care. Lotion is generally a single-phase product. Since the viscosity of the system is usually not high, a large amount of emulsifiers and suspension stabilizers are usually added to ensure the emulsification stability of the oil in the formula, but this will bring a sticky and heavy skin feeling. Double-layer emulsion is expected to solve this problem and is gradually attracting people's attention.

[0003] The upper layer of the traditional double-layer emulsion is a white emulsion layer, and the lower layer is a water layer with a higher degree of transparency. Generally, no suspension stabilizer is required, and the emulsifier content is low, so the skin feels light and the moisturizing power is better.

[0004] However, the existing double-layer emulsions have the problems of poor stability and single stratification form. After being placed for a long time, there are problems such as unclear interface between the two phases, turbidity of the lower layer, oily upper emulsion layer, etc.; and the existing double-layer emulsions mostly use water-in-oil emulsifiers, and the prepared double-layer emulsions are prone to stability problems such as high temperature or low temperature demulsification and uneven stratification.

[0005] The prior art improves the stability of the double-layer emulsion by selecting an appropriate emulsifier. For example, Chinese invention patent CN107929229B selects inulin lauryl carbamate as an emulsifier to provide a double-layer emulsion with a light skin feel and good stability. Chinese patent CN114146006B provides a double-layer emulsion with a light skin feel, using hydrogenated lecithin and sodium di(laurylamide glutamine) lysine as emulsifiers.

[0006] However, the above patent still does not solve the problem that the interface between the two phases is unclear, the lower layer is turbid, and the upper emulsion layer has oil after long-term storage. Summary of the invention

[0007] The object of the present invention is to provide a double-layer emulsion containing glycolipids. The present invention has the effect of relatively better stability.

[0008] The technical solution of the present invention is: a double-layer emulsion containing glycolipid, comprising multiple raw material components in mass percentage, wherein the raw material components are 0.3%-1.2% glycolipid, 0.15%-0.55% emulsifier, 2%-20% oil, 0.5%-2% inorganic salt and deionized water; the emulsifier comprises water-in-oil emulsifier and oil-in-water emulsifier, the mass percentage of the water-in-oil emulsifier is 0.05-0.15%, and the mass percentage of the oil-in-water emulsifier is 0.1-0.4%.

[0009] In the aforementioned double-layer emulsion containing glycolipid, the water-in-oil emulsifier includes one or more of polysorbate-60, polysorbate-80, polyglyceryl-10 laurate, and polyglyceryl-10 myristate; the oil-in-water emulsifier includes one or more of polyglyceryl-3 diisostearate, polyglyceryl-2 isostearate, and polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate.

[0010] In the aforementioned double-layer emulsion containing glycolipid, the oil is a composition of polar oil and non-polar oil; the non-polar oil includes but is not limited to one or more of isododecane, isohexadecane, C15-19 alkane, dicaprylyl ether, and polydimethylsiloxane; the polar oil includes but is not limited to one or more of neopentyl glycol diheptanoate, isodecyl neopentanoate, cetyl ethylhexanoate, triethylhexanoin, caprylic / capric triglyceride, isononyl isononanoate, coconut oil alcohol-caprylate / caprate, and isopropyl lauroyl amino acid.

[0011] In the aforementioned double-layer emulsion containing glycolipid, the inorganic salt is one or more of sodium chloride and potassium chloride.

[0012] The aforementioned double-layer emulsion containing glycolipids further comprises a pH regulator to adjust the pH of the double-layer emulsion containing glycolipids to 5.57-6.85; the pH regulator comprises at least one or more of citric acid, sodium citrate, dipotassium hydrogen phosphate and potassium phosphate.

[0013] In the aforementioned double-layer emulsion containing glycolipid, the mass percentage of the glycolipid is 0.5%-0.9%.

[0014] In the aforementioned double-layer emulsion containing glycolipid, the mass percentage of the inorganic salt is 0.8%-1.5%.

[0015] The aforementioned double-layer emulsion containing glycolipid includes the following preparation method:

[0016] A. Weigh 0.3%-1.2% glycolipid, 0.15%-0.55% emulsifier, 2%-20% oil, 0.5%-2% inorganic salt, appropriate amount of pH regulator and the balance deionized water according to the following mass percentages;

[0017] B. Mix the inorganic salt, pH adjuster, glycolipid and water weighed in step A, stir evenly, and heat to 75-80° C. to obtain an aqueous phase;

[0018] C. Mix the oil and emulsifier weighed in step A, and stir at 75-80° C. for 5-10 minutes to obtain an oil phase;

[0019] D. Add the oil phase obtained in step C to the water phase obtained in step B, and homogenize at 75-80° C. and 6000-8000 rpm for 2-5 minutes to obtain component D;

[0020] E. Cool component D to 35-40°C, homogenize at 4000-6000 rpm for 1-3 minutes, and let stand for a certain period of time to separate the layers to obtain a finished double-layer emulsion.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] 1. The present invention adds glycolipids to the conventional double-layer emulsion formula and simultaneously compounding a specific emulsifier, so that the prepared double-layer emulsion has obvious stratification effect, clear two-phase interface, and good stability. After being stored at high temperature (50°C) and low temperature (-10°C) for four weeks and returning to room temperature, it is still a double-layer that is transparent on the top and transparent on the bottom, which effectively solves the problems of poor stability and single stratification form of conventional double-layer emulsions;

[0023] 2. Existing double-layer emulsions mostly use water-in-oil emulsifiers, and the prepared double-layer emulsions are prone to high-temperature or low-temperature demulsification and uneven stratification stability problems. The emulsifier used in the present invention is composed of the above-mentioned selected water-in-oil emulsifier and oil-in-water emulsifier. The compound selected emulsifier can significantly improve the stability;

[0024] 3. The present invention adds glycolipid, and the amount of addition has a great influence on the stratification form, and can prepare a stratified state of upper transparent and lower transparent, which is different from the traditional stratified state of upper white and lower transparent;

[0025] 4. The upper layer of the double-layer emulsion prepared by the present invention is a transparent oil phase, and the lower layer is a transparent water phase. Shake well before use to obtain a uniform white emulsion, giving consumers more visual experience;

[0026] 5. The present invention can improve the antiseptic effect of the formula and reduce the risk of microbial contamination of the product by adding glycolipids;

[0027] 6. The present invention has a simple operation process, is easy to operate, and is convenient for industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 is the stability test result of the embodiment of the present invention;

[0029] Figure 2 It is the stability test result of the comparative example of the present invention. DETAILED DESCRIPTION

[0030] The present invention is further described below in conjunction with the accompanying drawings and embodiments, but they are not intended to limit the present invention.

[0031] Example 1. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in mass percentage, specifically 0.3% glycolipids, 0.05% polysorbate-60, 0.1% polyglycerol-4 diisostearate / polyhydroxystearate / sebacate, 2% isohexadecane, 1% caprylic / capric triglyceride, 0.8% sodium chloride, 0.05% sodium citrate to adjust the product pH to 5.69, and the balance deionized water.

[0032] The preparation method is:

[0033] A. Weigh 0.3% glycolipid, 0.05% polysorbate 60, 0.1% polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, 2% isohexadecane, 1% caprylic / capric triglyceride, 0.8% sodium chloride, 0.05% sodium citrate, and the balance deionized water according to the following mass percentages;

[0034] B. Mix the sodium chloride, sodium citrate, glycolipid and water weighed in step A, stir evenly, and heat to 75-80° C. to obtain an aqueous phase;

[0035] C. Mix the polysorbate 60, polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, isohexadecane, and caprylic / capric triglyceride weighed in step A, and stir at 75-80° C. for 5-10 minutes to obtain an oil phase;

[0036] D. Add the oil phase obtained in step C to the water phase obtained in step B, and homogenize at 75-80° C. and 6000-8000 rpm for 2-5 minutes to obtain component D;

[0037] E. Cool component D to 35-40°C, homogenize at 4000-6000 rpm for 1-3 minutes, and let stand for a certain period of time to separate into layers to obtain a double-layer emulsion.

[0038] Example 2. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in percentage by weight, specifically 0.5% glycolipids, 0.05% polysorbate-60, 0.2% polyglycerol-4 diisostearate / polyhydroxystearate / sebacate, 3% isohexadecane, 2% neopentyl glycol diheptanoate, 1% sodium chloride, 0.1% sodium citrate to adjust the product pH to 5.90, and the balance deionized water.

[0039] The preparation method is similar to that of Example 1.

[0040] Example 3. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in mass percentage, specifically 0.6% glycolipids, 0.1% polyglycerol-10 laurate, 0.3% polyglycerol-4 diisostearate / polyhydroxystearate / sebacate, 3% C15-19 alkane, 5% neopentyl glycol diheptanoate, 1.5% sodium chloride, 0.1% sodium citrate to adjust the product pH to 5.70, and the balance deionized water.

[0041] The preparation method is similar to that of Example 1.

[0042] Example 4. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in mass percentage, specifically 0.7% glycolipids, 0.1% polyglyceryl-10 laurate, 0.3% polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, 4% isohexadecane, 1% caprylic / capric triglyceride, 2% neopentyl glycol diheptanoate, 1.2% sodium chloride, 0.1% sodium citrate to adjust the product pH to 5.74, and the balance deionized water.

[0043] The preparation method is similar to that of Example 1.

[0044] Example 5. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in mass percentage, specifically 0.8% glycolipids, 0.1% polyglycerol-10 laurate, 0.3% polyglycerol-4 diisostearate / polyhydroxystearate / sebacate, 8% C15-19 alkane, 2% caprylic / capric triglyceride, 0.8% sodium chloride, 0.1% sodium citrate to adjust the product pH to 5.57, and the balance deionized water.

[0045] The preparation method is similar to that of Example 1.

[0046] Example 6. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in mass percentage, specifically 0.9% glycolipids, 0.1% polyglyceryl-10 laurate, 0.3% polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, 8% C15-19 alkane, 2% neopentyl glycol diheptanoate, 2% glyceryl tri(ethylhexanoate), 0.5% sodium chloride, 0.2% sodium citrate to adjust the pH of the product to 6.10, and the balance deionized water.

[0047] The preparation method is similar to that of Example 1.

[0048] Example 7. A double-layer emulsion containing glycolipids, comprising a plurality of raw material components in percentage by weight, specifically 1.2% glycolipids, 0.15% polyglyceryl-10 laurate, 0.4% polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, 8% C15-19 alkane, 7% isohexadecane, 5% coconut oil alcohol-caprylate / caprate, 2.0% sodium chloride, 0.2% sodium citrate to adjust the product pH to 6.85, and the balance is deionized water.

[0049] The preparation method is similar to that of Example 1.

[0050] Experimental comparison and verification

[0051] Comparative Example 1: This comparative example provides a double-layer emulsion, and the component ratio of the raw materials for preparation is similar to that of Example 5, except that no glycolipid is added in this comparative example;

[0052] Comparative Example 2: This comparative example provides a double-layer emulsion. The component ratio of the raw materials used in the preparation is similar to that of Example 5, except that the amount of glycolipid added in this comparative example is 0.1%.

[0053] Comparative Example 3: This comparative example provides a double-layer emulsion, and the component ratio of the raw materials for preparation is similar to that of Example 5, except that sodium chloride is not added in this comparative example.

[0054] Comparative Example 4: This comparative example provides a double-layer emulsion. The component ratio of the raw materials used in the preparation is similar to that of Example 5, except that the amount of sodium chloride added in this comparative example is 0.2%.

[0055] Comparative Example 5: This comparative example provides a double-layer emulsion. The component ratio of the raw materials used in the preparation is similar to that of Example 5, except that sodium citrate is not added in this comparative example, and the pH value is 5.25.

[0056] The double-layer emulsions prepared in the examples and comparative examples were subjected to stability tests and antiseptic challenge tests. The specific test methods and results are shown below.

[0057] 1. Stability test

[0058] The present invention places the prepared double-layer emulsion under different temperature conditions to examine its changes at different temperatures. The test results are shown in Table 1. Figure 1 and Figure 2 As shown, the recorded results are all obtained by taking out the samples after they have been placed at different temperatures for a certain period of time, and recording the changes in appearance after the samples have returned to room temperature.

[0059] From Table 1, Figure 1 and Figure 2 As a result, each embodiment is relatively stable during the investigation period, and no obvious abnormal stability occurs. However, the stratification of Comparative Examples 1-5 in the initial state is different, and during the investigation period, abnormal stability occurs. Specific analysis shows that the abnormal stability of Comparative Examples 1 and 2 indicates that the amount of glycolipid added needs to be within the range selected by the present invention, the abnormal stability of Comparative Examples 3 and 4 indicates that the amount of inorganic salt added must be within the range selected by the present invention, and the abnormal stability of Comparative Example 5 indicates that the pH of the formula must be within the range selected by the present invention.

[0060] Table 1 Stability test results

[0061]

[0062]

[0063] 2. Anticorrosion Challenge Test In order to verify that the addition of glycolipids can improve the anticorrosion performance of the double-layer emulsion, the present invention uses Example 5 and Comparative Example 1 to perform anticorrosion challenge tests. The specific method is based on ISO11930 and China

[0064] "Technical Guidelines for Cosmetic Preservative Challenge Tests", the test results are shown in Table 2.

[0065] Table 2 Anticorrosion challenge test results

[0066]

[0067] From the test results of the antiseptic challenge in the table, it can be seen that Example 5 showed obvious inhibitory effects on bacteria and Aspergillus niger on the 7th day, and showed excellent inhibitory effects on bacteria, Aspergillus niger and Candida albicans on the 14th day, and showed more excellent effects of inhibiting the growth of various colonies on the 28th day; while Comparative Example 1 only had a certain inhibitory effect on bacteria on the 7th day and was far inferior to the inhibitory effect of Example 5 on bacteria. On the 14th day, Comparative Example 1 showed better inhibitory effect on bacteria, and also had certain inhibitory effects on Aspergillus niger and Candida albicans, but was still inferior to the inhibitory effect of Example 5 on various colonies. It was not until the 28th day that the inhibitory effects of Comparative Example 1 and Example 5 on various colonies were relatively close.

[0068] From the above analysis, it can be seen that in the antiseptic challenge test, Example 5 has a significantly better inhibitory effect on the growth of various bacterial colonies than Comparative Example 1, which illustrates that glycolipids have an antiseptic and synergistic effect in the formula, thereby reducing the risk of microbial contamination of the product.

Claims

1. A double-layer emulsion containing glycolipid, characterized in that: The invention comprises a plurality of raw material components in the following mass percentages, wherein the raw material components are 0.3%-1.2% of glycolipid, 0.15%-0.55% of emulsifier, 2%-20% of oil, 0.5%-2% of inorganic salt and the balance of deionized water; the emulsifier comprises an oil-in-water emulsifier and an oil-in-water emulsifier, the mass percentage of the oil-in-water emulsifier is 0.05-0.15%, and the mass percentage of the oil-in-water emulsifier is 0.1-0.4%.

2. A double-layer emulsion containing glycolipid according to claim 1, characterized in that: The water-in-oil emulsifier includes one or more of polysorbate-60, polysorbate-80, polyglyceryl-10 laurate, and polyglyceryl-10 myristate; the oil-in-water emulsifier includes one or more of polyglyceryl-3 diisostearate, polyglyceryl-2 isostearate, and polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate.

3. A double-layer emulsion containing glycolipid according to claim 1, characterized in that: The oil is a composition of polar oil and non-polar oil; the non-polar oil includes but is not limited to one or more of isododecane, isohexadecane, C15-19 alkane, dicaprylyl ether, and polydimethylsiloxane; the polar oil includes but is not limited to one or more of neopentyl glycol diheptanoate, isodecyl neopentanoate, cetyl ethylhexanoate, triethylhexanoin, caprylic / capric triglyceride, isononyl isononanoate, coconut oil caprylate / caprate, and isopropyl lauroyl amino acid.

4. A double-layer emulsion containing glycolipid according to claim 1, characterized in that: The inorganic salt is one or more of sodium chloride and potassium chloride.

5. A double-layer emulsion containing glycolipid according to claim 1, characterized in that: The method further comprises a pH regulator, which is used to adjust the pH of the glycolipid-containing double-layer emulsion to 5.57-6.85; the pH regulator comprises at least one or more of citric acid, sodium citrate, dipotassium hydrogen phosphate and potassium phosphate.

6. A double-layer emulsion containing glycolipid according to claim 2, characterized in that: The mass percentage of the glycolipid is 0.5%-0.9%.

7. A double-layer emulsion containing glycolipid according to claim 1, characterized in that: The mass percentage of the inorganic salt is 0.8%-1.5%.

8. A double-layer emulsion containing glycolipid according to any one of claims 1 to 7, characterized in that: The invention comprises the following preparation method: A. Weigh 0.3%-1.2% glycolipid, 0.15%-0.55% emulsifier, 2%-20% oil, 0.5%-2% inorganic salt, and the balance deionized water according to the following mass percentages; B. Mix the inorganic salt, glycolipid and water weighed in step A, add a pH adjuster to a pH of 5.57-6.85, stir evenly, and heat to 75-80° C. to obtain an aqueous phase; C. Mix the oil and emulsifier weighed in step A, and stir at 75-80° C. for 5-10 minutes to obtain an oil phase; D. Add the oil phase obtained in step C to the water phase obtained in step B, and homogenize at 75-80° C. and 6000-8000 rpm for 2-5 minutes to obtain component D; E. Cool component D to 35-40°C, homogenize at 4000-6000 rpm for 1-3 minutes, and let stand for a certain period of time to separate the layers to obtain a finished double-layer emulsion.

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