Isolator system of integrated air conditioner

Abstract

The invention relates to an isolator system of an integrated air conditioner. The isolator system comprises the integrated air conditioner, an isolator static pressure box and an isolator cavity. The isolator cavity is connected to a matched equipment bottom plate, the upper portion of the isolator cavity is communicated with the isolator static pressure box, and the integrated air conditioner is arranged above the isolator static pressure box. The front side of the integrated air conditioner is connected with an air conditioner overhaul cover plate; the front side of the isolator plenum chamber is connected with a plenum chamber access cover plate. The integrated air conditioner comprises an air conditioner air chamber body shell, an air draft fan is arranged in the air conditioner air chamber body shell, and the air draft fan communicates with a cavity air return pipe. The lower end of the air conditioner air chamber body shell communicates with the isolator static pressure box, and an air conditioner air return baffle assembly is arranged at the communicating position. The isolator system of the integrated air conditioner is provided for overcoming the existing defects, the requirements for plant space and supporting facilities are reduced, the site construction delivery cost is reduced, the equipment energy consumption is reduced, and the equipment regulation and control timeliness is improved.

Description

Technical Field

[0001] The present invention relates to an isolator system integrated with air conditioning. Background Art

[0002] The isolator is a complex system that controls the unidirectional airflow, pressure difference, temperature and humidity, and particle number within the equipment during the production process, and combines core area purification methods to reduce the bioburden in the core area to a certain level, thereby providing a controlled sterile environment for sterile preparations during the production process.

[0003] In order to meet the requirements of temperature, humidity, pressure difference, etc. during the production and purification process inside the equipment, the mainstream practice of existing isolator equipment manufacturers is to equip the isolator with a set of exhaust components and fresh air components, and at the same time equip it with an independent air conditioning system. The fresh air interface and exhaust interface of the isolator are connected to the air conditioning system through air ducts for internal and external circulation in different modes of the isolator.

[0004] The disadvantages of this approach are: because the isolator and air conditioner need to be installed separately, the plant space requirement is large, and sometimes due to limited plant space, the isolator equipment air conditioning and the plant air conditioning will interfere with each other; it is necessary to entrust a design institute to design the duct diagram between the isolator and the air conditioner, and entrust an engineering company to install the connecting duct; the distance from the air conditioner to the equipment is increased, which increases energy consumption and reduces the timeliness of equipment control response; when the air conditioner is installed in the technical mezzanine, additional air conditioner bases and lifting platforms are required, increasing costs; because the equipment and air conditioner are in different areas, it is often necessary to equip the equipment and air conditioner with two sets of power distribution cabinets and control cabinets; because the exhaust components often need to be dismantled and transported before shipment, the secondary installation and lifting work of the exhaust components is increased after the equipment arrives at the client's site; the on-site construction period and project delivery costs are increased.

[0005] Therefore, in view of the above problems, an isolator system with integrated air conditioning is proposed. Summary of the invention

[0006] The purpose of the present invention is to overcome the existing defects and provide an isolator system with integrated air conditioning, reduce the requirements for plant space and supporting facilities, reduce on-site construction delivery costs, reduce equipment energy consumption, and improve the timeliness of equipment regulation.

[0007] The technical solution to achieve the above-mentioned purpose is: an isolator system with integrated air conditioning, comprising an integrated air conditioning, an isolator static pressure box and an isolator cavity; the isolator cavity is connected to the bottom plate of the supporting equipment, the top of the isolator cavity is connected to the isolator static pressure box, and the integrated air conditioning is arranged above the isolator static pressure box; the front side of the integrated air conditioning is connected to an air conditioning maintenance cover; the front side of the isolator static pressure box is connected to a static pressure box maintenance cover.

[0008] Preferably, the integrated air conditioner comprises an air conditioning chamber main body shell, an exhaust fan is arranged in the air conditioning chamber main body shell, and the exhaust fan is connected with the cavity return air duct; the lower end of the air conditioning chamber main body shell is connected with the isolator static pressure box, and an air conditioning return air baffle assembly is arranged at the connection point; a return air catalytic decomposition filter assembly is arranged below the air conditioning return air baffle assembly; the right side wall of the air conditioning chamber main body shell is connected with the cooling and heating coil assembly;

[0009] The main shell of the air conditioning chamber is connected to a fresh air duct and an exhaust air duct, and the fresh air duct is provided with a fresh air electric air volume regulating butterfly valve; the exhaust air duct is provided with an exhaust air electric air volume regulating butterfly valve.

[0010] Preferably, the air conditioning return air baffle assembly includes a first pneumatic cylinder, the first pneumatic cylinder is sleeved with a first pneumatic slider, the first pneumatic slider is connected to the return air baffle, and first sliding bearings are arranged on both sides of the return air baffle; the first pneumatic slider is connected to a first position signal sensor.

[0011] Preferably, the refrigeration and heating coil assembly includes a refrigeration coil and a heating coil; the refrigeration coil is respectively connected to the first refrigeration / heating medium public engineering pipeline and the first manual accessory group; the heating coil is respectively connected to the second refrigeration / heating medium public engineering pipeline and the second manual accessory group; the refrigeration electric proportional control valve is installed on the first refrigeration / heating medium public engineering pipeline; the heating electric proportional control valve is installed on the second refrigeration / heating medium public engineering pipeline.

[0012] Preferably, the return air catalytic decomposition filter assembly includes a filter fixing rail, a second pneumatic cylinder is installed on the filter fixing rail, the second pneumatic cylinder is connected to a second pneumatic slider, the second pneumatic slider is connected to a filter mounting frame, a primary filter and a decomposition filter are connected inside the filter mounting frame; second sliding bearings are connected to both sides of the filter mounting frame, the second sliding bearings are slidably connected to the filter fixing rail; second position signal sensors are connected to both ends of the second pneumatic cylinder.

[0013] Preferably, the isolator static pressure box includes a high-efficiency filter support plate and an FFU circulation high-efficiency component; the high-efficiency filter support plate is connected to the cavity main body frame, the lighting lamp is installed on the bottom side of the high-efficiency filter support plate, the FFU circulation high-efficiency component is installed on the high-efficiency filter support plate, the fresh air return air mixing channel is installed on the top upper side of the FFU circulation high-efficiency component, the circulation high-efficiency PAO monitoring port is installed on the outside of the side of the fresh air return air mixing channel, the sterilization evaporation plate assembly is installed on the inner side wall of the fresh air return air mixing channel, the return air catalytic decomposition filter assembly is installed below the return air port inside the fresh air return air mixing channel, and the static pressure box decorative panel is installed on the outside of the static pressure box.

[0014] Preferably, the FFU circulation high-efficiency component includes an FFU circulation fan chamber housing, a liquid tank circulation high-efficiency filter with a filtration grade of H14 is pressed against the bottom edge of the FFU circulation fan chamber housing by six high-efficiency fixing blocks, a circulation fan support plate is installed inside the FFU circulation fan chamber housing, the circulation fan is installed on the circulation fan support plate, and the fan speed regulator is installed outside the FFU circulation fan chamber housing.

[0015] Preferably, the isolator cavity includes a cavity main frame, a glass window assembly is installed on the cavity main frame, the cavity return air duct is connected to the cavity body and the integrated air conditioner, the return air high-efficiency filter is installed at the bottom of the cavity main frame, the return air high-efficiency inspection cover is installed on the bottom side of the cavity return air duct, the flow equalizing membrane is installed on the top of the cavity, the loading rod, temperature and humidity sensors, concentration sensors, wind speed sensors, cavity differential pressure sensors, and safety gratings are installed on the inner wall of the cavity, the online particle monitoring points and the online planktonic bacteria monitoring points are installed inside the cavity, and the spray gun is installed inside the isolator cavity.

[0016] Preferably, the glass window assembly includes a transparent tempered glass window, a hinge, a door lock, a door signal sensor, a glove port, an airtight seal and a sterile transfer RTP system; the transparent tempered glass window is connected to the cavity main frame through the hinge; the transparent tempered glass window is respectively provided with the hinge, the door lock, the door signal sensor, the glove port, the airtight seal and the sterile transfer RTP system.

[0017] Preferably, a condensate water collection pan is installed below the refrigeration coil, and the lowest point of the bottom of the condensate water collection pan is connected to an external electric ball valve of the equipment through a condensate water drain pipe.

[0018] Preferably, the pressure relief valve is installed on the top of the air conditioning chamber main body shell, and the decomposition filter assembly is installed at the rear end of the pressure relief valve;

[0019] The air pipe installation plate and the aviation plug-in joint are installed on the top of the air conditioning chamber main body shell, and the air conditioning maintenance cover plate is installed on the side of the air conditioning chamber main body shell.

[0020] The beneficial effects of the present invention are as follows: the isolator system of the integrated air conditioner has a compact design, a smaller overall size, and a smaller space required for the plant, which is more convenient for the design of the equipment plant; the air duct connecting the isolator and the air conditioner in the original technical route is cancelled, reducing the design and construction workload of the plant air duct; the air conditioning system is above the isolator body and is closer, so that the air conditioning has a higher timeliness in regulating the temperature and humidity in the isolator; after the isolator and the air conditioner are integrated, they can share a set of power distribution cabinets and control cabinets, saving costs; the structural design is optimized, and the air conditioning power system and the exhaust power system in the original plan are taken into account by the air conditioning power system, reducing the energy consumption of the air conditioner. After integration, the equipment can be shipped as a whole, reducing the secondary installation and hoisting work on site of Party A; the original technical air conditioning base and installation platform are cancelled, reducing the corresponding hoisting workload. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a schematic diagram of an isolator system of an integrated air conditioner of the present invention;

[0022] Figure 2 is a half-section view of an isolator system of an integrated air conditioner of the present invention;

[0023] Figure 3 is a schematic diagram of an air conditioner return air baffle assembly of the present invention;

[0024] Figure 4 is a schematic diagram of a return air catalytic decomposition filter assembly of the present invention;

[0025] Figure 5 It is a schematic diagram of the FFU circulation high efficiency component of the present invention;

[0026] Figure 6 is a schematic diagram of a glass window assembly of the present invention;

[0027] Figure 7 is a schematic diagram of a refrigeration and heating coil assembly of the present invention;

[0028] Figure 8 It is a schematic diagram of the process flow of the isolator system of the integrated air conditioner of the present invention.

[0029] In the figure: 1. Integrated air conditioner; 2. Isolator static pressure box; 3. Isolator cavity; 4. Supporting equipment bottom plate; 5. Air conditioner maintenance cover; 6. Static pressure box maintenance cover; 8. Pressure relief valve; 9. Disassembly filter assembly; 10. Aviation plug-in connector; 11. Air pipe installation plate; 12. Exhaust fan; 13. Air conditioner air chamber main body shell; 14. Air conditioner return air damper assembly; 15. Fresh air electric air volume adjustment butterfly valve; 16. Exhaust air duct; 17. Exhaust air electric air volume adjustment butterfly valve; 18. Fresh air duct; 19. Refrigeration and heating coil assembly; 20. Condensate water accumulation tray; 21. Condensate drain pipe; 22. Electric ball valve; 23. Electric air volume regulating valve; 24. Fresh air return air mixing channel; 25. Return air catalytic decomposition filter assembly; 26. FFU circulation high-efficiency assembly; 27. Static pressure box decorative plate; 28. Sterilization evaporation plate assembly; 29. ​​Filter support plate; 30. Lighting lamp; 31. Cavity return air duct; 32. Wind speed sensor; 33. Glass window assembly; 34. Safety grating; 35. Concentration sensor; 36. Return air high-efficiency filter; 37. Flow equalization membrane; 38. Loading hanging rod; 39. Cavity differential pressure sensor; 40. Temperature and humidity Degree sensor; 41, main frame; 42, first position signal sensor; 43, first pneumatic cylinder; 44, first pneumatic slider; 45, return air baffle; 46, first sliding bearing; 47, filter fixing rail; 48, second pneumatic cylinder; 49, second pneumatic slider; 50, filter installation frame; 51, primary filter; 52, decomposition filter; 53, FFU circulation fan air chamber housing; 54, circulation fan; 56, liquid tank circulation high-efficiency filter; 57, high-efficiency fixing block; 58, fan speed regulator; 59, transparent tempered glass window; 60 , hinge; 61, glove port; 62, sterile transfer RTP system; 63, door lock; 64, door signal sensor; 65, airtight seal; 66, refrigeration coil; 67, heating coil; 68, first refrigeration / heating medium public engineering pipeline; 69, refrigeration electric proportional control valve; 70, first manual accessory group; 71, heating electric proportional control valve; 72, second refrigeration / heating medium public engineering pipeline; 73, second manual accessory group; 74, circulation high-efficiency PAO monitoring port; 75, particle online monitoring point; 76, planktonic bacteria online monitoring point; 77, spray gun. DETAILED DESCRIPTION

[0030] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, which are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0031] The present invention will be further described below in conjunction with the accompanying drawings.

[0032] like Figure 1-8 As shown, an isolator system with integrated air conditioning includes an integrated air conditioning 1, an isolator static pressure box 2 and an isolator cavity 3; the isolator cavity 3 is connected to the supporting equipment bottom plate 4, the isolator cavity 3 is connected to the isolator static pressure box 2 above, and the integrated air conditioning 1 is arranged above the isolator static pressure box 2; the front side of the integrated air conditioning 1 is connected to an air conditioning maintenance cover 5; the front side of the isolator static pressure box 2 is connected to a static pressure box maintenance cover 6.

[0033] like Figure 2 As shown, the integrated air conditioner 1 includes an air conditioning chamber main body shell 13, in which an exhaust fan 12 is arranged, and the exhaust fan 12 is connected to the cavity return air duct 31; the lower end of the air conditioning chamber main body shell 13 is connected to the isolator static pressure box 2, and an air conditioning return air baffle assembly 14 is arranged at the connection point; a return air catalytic decomposition filter assembly 25 is arranged below the air conditioning return air baffle assembly 14; the right side wall of the air conditioning chamber main body shell 13 is connected to the refrigeration and heating coil assembly 19; the air conditioning chamber main body shell 13 is connected to the fresh air duct 18 and the exhaust air duct 16, and the fresh air duct 18 is provided with a fresh air electric air volume regulating butterfly valve 15; the exhaust air duct 16 is provided with an exhaust air electric air volume regulating butterfly valve 17.

[0034] Specifically, the pressure relief valve 8 is installed on the top of the air conditioning chamber main body shell 13, and the decomposition filter assembly 9 is installed at the rear end of the pressure relief valve 8; the air pipe mounting plate 11 and the aviation plug-in connector 10 are installed on the top of the air conditioning chamber main body shell 13, and the air conditioning inspection cover 5 is installed on the side of the air conditioning chamber main body shell 13.

[0035] Specifically, the pressure relief valve 8 is installed on the top of the air conditioning chamber main body shell 13, and the decomposition filter assembly 9 is installed at the rear end of the pressure relief valve 8. When the cavity pressure is too high during VHP, the equipment automatically releases pressure. At the same time, the hydrogen peroxide in the pressure relief gas is fully decomposed by the decomposition filter, reducing the impact of residual hydrogen peroxide on the external environment.

[0036] Specifically, the air pipe mounting plate 11 and the aviation plug connector 10 are installed on the top of the air chamber main body shell 13, and the air conditioner maintenance cover 5 is installed on the side of the air chamber main body shell 13. The air conditioner maintenance cover can be quickly opened to achieve the wiring installation of the equipment. Using aviation plug wiring can achieve quick docking and connection after delivery to Party A, shortening the on-site installation period.

[0037] Specifically, the main shell body 13 of the air conditioning chamber is directly connected to the top of the cavity return air duct 31 through the bottom opening of the front section to form an integrated air duct ①, and the rear area of ​​the exhaust fan 12 in the middle section is connected with the bottom and the top of the fresh air return air mixing channel 24 of the isolator static pressure box 2 to form an integrated air duct ②, and the bottom end and the top end of the fresh air & return air mixing channel 24 of the static pressure box form an integrated air duct ③. The top is designed with an air conditioning fresh air inlet and an exhaust outlet. Through the integrated air duct design, the air duct required for connecting the air conditioner and the isolator in the original solution is eliminated.

[0038] Specifically, the exhaust fan 12 is installed on the mounting plate at the front section inside the air conditioning chamber main body shell 13, taking into account the power source of the isolator cavity return air, the static pressure box return air and the air conditioning exhaust air, so as to achieve the purpose of energy saving.

[0039] Specifically, a fresh air electric air volume regulating butterfly valve 15 is installed on the air conditioning fresh air inlet of the air conditioning air chamber main body shell 13, an exhaust air electric air volume regulating butterfly valve 17 is installed on the air conditioning exhaust outlet, an electric air volume regulating valve 23 is installed on the middle mounting plate, and a refrigeration and heating coil assembly 19 is installed behind the electric air volume regulating valve 23. According to the temperature, humidity and pressure difference data measured by the pressure difference sensor 39 and the temperature and humidity sensor 40 inside the cavity, the corresponding valve opening angle and the speed of the exhaust fan 12 can be adjusted through the equipment control system to realize the replacement and temperature regulation of the internal return air and fresh air ratio, thereby realizing the regulation of the temperature, humidity and pressure difference inside the isolator cavity.

[0040] Specifically, the fresh air outlet of the air conditioner is equipped with a fresh air electric air volume regulating butterfly valve 15, which directly takes air from the clean room through the fresh air duct 18. The opening of the fresh air electric air volume regulating butterfly valve 15 is adjusted by PID based on the internal parameters of the equipment to control the required fresh air volume, while reducing the length of the air duct.

[0041] like Figure 3 As shown, the air conditioning return air baffle assembly 14 includes a first pneumatic cylinder 43, the first pneumatic cylinder 43 is sleeved with a first pneumatic slider 44, the first pneumatic slider 44 is connected to a return air baffle 45, and first sliding bearings 46 are provided on both sides of the return air baffle 45; the first pneumatic slider 44 is connected to a first position signal sensor 42.

[0042] Specifically, compressed air at both ends of the first pneumatic cylinder 43 drives the first pneumatic slider 44 to move on the first pneumatic cylinder 43, driving the return air baffle 45 to move through four first sliding bearings 46, and the position of the first pneumatic slider 44 is sensed by two groups of first position signal sensors 42 at both ends, thereby controlling the return air baffle 45 to control the opening and closing of the integrated air duct ②.

[0043] like Figure 7 As shown, the cooling and heating coil assembly 19 includes a cooling coil 66 and a heating coil 67; the cooling coil 66 is respectively connected to the first cooling / heating medium public engineering pipeline 68 and the first manual accessory group 70; the heating coil 67 is respectively connected to the second cooling / heating medium public engineering pipeline 72 and the second manual accessory group 73; the cooling electric proportional regulating valve 69 is installed on the first cooling / heating medium public engineering pipeline 68; the heating electric proportional regulating valve 71 is installed on the second cooling / heating medium public engineering pipeline 72. A condensate water accumulation pan 20 is installed below the cooling coil 66, and the lowest point of the bottom of the condensate water accumulation pan 20 is connected to the external electric ball valve 22 of the equipment through the condensate water drainage pipe 21.

[0044] Specifically, by regulating the opening of the cooling electric proportional control valve 69 and the heating electric proportional control valve 71 through PID, the flow of the cooling medium and the heating medium can be regulated, thereby achieving different heat exchange heats of the cooling coil and the heating coil, thereby achieving temperature control. A condensate water accumulation pan 20 is installed below the cooling coil 66. The lowest point at the bottom of the condensate water accumulation pan 20 is connected to the external electric ball valve 22 of the equipment through the condensate water drain pipe 21, which can realize the automatic discharge of the air conditioning condensate pipe and the automatic closure during the equipment leakage test.

[0045] like Figure 4 As shown, the return air catalytic decomposition filter assembly 25 includes a filter fixing rail 47, a second pneumatic cylinder 48 is installed on the filter fixing rail 47, the second pneumatic cylinder 48 is connected to a second pneumatic slider 49, the second pneumatic slider 49 is connected to a filter mounting frame 50, a primary filter 51 and a decomposition filter 52 are connected inside the filter mounting frame 50; second sliding bearings are connected to both sides of the filter mounting frame 50, and the second sliding bearings are slidably connected to the filter fixing rail 47; second position signal sensors are connected to both ends of the second pneumatic cylinder 48.

[0046] Specifically, the bottom end surface of the filter fixing guide rail 47 is connected to the filter; the second pneumatic slider 49 is driven by compressed air at both ends of the second pneumatic cylinder 48 to move on the second pneumatic cylinder 48, and the filter mounting frame 50 is driven to move through four second sliding bearings, and the position of the second pneumatic slider 49 is sensed by two groups of second position signal sensors at both ends, thereby controlling the positions of the primary filter 51 and the decomposition filter 52.

[0047] Specifically, the return air catalytic decomposition filter assembly 25 is installed below the return air outlet of the integrated air duct ② at the bottom of the air conditioning air chamber main body shell 13, the return air baffle assembly 14 is installed above the return air outlet of the integrated air duct ② at the bottom of the air conditioning air chamber main body shell 13, and the return air catalytic decomposition filter assembly is installed below the return air outlet of the integrated air duct ② at the bottom of the air conditioning air chamber main body shell 13. The integrated air duct ② can be opened or closed by adjusting the position of the return air baffle 45 in the air conditioning return air baffle assembly 14, so as to realize the selection of the connecting air duct between the static pressure box and the air conditioner in different modes of the isolator. In the isolator production mode, the air conditioning return air baffle assembly 14 is controlled to close the integrated air duct ②, open the electric air volume regulating valve 23, and realize the air flow in the air conditioning and static pressure box to go through the production air duct. In the VHP residual exhaust mode, the air conditioning return air baffle assembly 14 is controlled to open the integrated air duct ②, close the electric air volume regulating valve 23, and realize the air flow in the air conditioning and static pressure box to go through the fast decomposition channel, thereby reducing the sterilization time.

[0048] Specifically, the isolator static pressure box 2 includes a high-efficiency filter support plate 29 and a FFU circulation high-efficiency component 26; the high-efficiency filter support plate 29 is connected to the cavity main frame 41, the lighting lamp 30 is installed on the bottom side of the high-efficiency filter support plate 29, the FFU circulation high-efficiency component 26 is installed on the high-efficiency filter support plate 29, the fresh air return air mixing channel 24 is installed on the top upper side of the FFU circulation high-efficiency component 26, the circulation high-efficiency PAO monitoring port 74 is installed on the outside of the side of the fresh air return air mixing channel 24, the sterilization evaporation plate assembly 28 is installed on the inner side wall of the fresh air return air mixing channel 24, the return air catalytic decomposition filter assembly 25 is installed below the return air port inside the fresh air return air mixing channel 24, and the static pressure box decorative panel 27 is installed on the outside of the static pressure box.

[0049] Specifically, the VHP evaporation disk assembly is connected to an external hydrogen peroxide delivery unit to achieve hydrogen peroxide vaporization. The vaporized hydrogen peroxide in the fresh air return air mixing channel 24 is transported to the isolator cavity 3 through the circulation fan assembly 26, and then powered by the exhaust fan 12, reaches the inside of the air conditioning air chamber main body shell 13 through the cavity return air duct 31, and then reaches the inside of the fresh air return air mixing channel 24 through the integrated air duct ②. In this way, the circulation of the hydrogen peroxide sporicide is achieved to achieve the sterilization effect inside the isolator cavity. Generally, the sterilization effect on the exposed surface can achieve a 6-log reduction of the high-resistance biological indicator.

[0050] like Figure 5As shown, the FFU circulation high-efficiency component 26 includes an FFU circulation fan air chamber housing 53, a liquid tank circulation high-efficiency filter 56 with a H14 filtration grade is pressed on the bottom blade of the FFU circulation fan air chamber housing 53 by six high-efficiency fixing blocks 57, a circulation fan support plate 55 is installed inside the FFU circulation fan air chamber housing 53, a circulation fan 54 is installed on the circulation fan support plate 55, and a fan speed regulator 58 is installed outside the FFU circulation fan air chamber housing 55. The liquid tank circulation high-efficiency filter 56 with a H14 filtration grade can efficiently filter the particles of the gas inside the isolator cavity by the static pressure difference, and prevent the destruction of the sterile environment for the production of sterile drugs. The circulation fan 54 can adjust the fan speed by PID according to the wind speed measured by the wind speed sensor 32 in the isolator cavity 3 to achieve the regulation of the wind speed in the isolator cavity 3, which is generally controlled at 0.45m / s±20%.

[0051] Specifically, the isolator cavity 3 includes a cavity main frame 41, a glass window assembly 33 is installed on the cavity main frame 41, a cavity return air duct 31 connects the cavity body and the integrated air conditioner 1, a return air high-efficiency filter 36 is installed at the bottom of the cavity main frame 41, a return air high-efficiency inspection cover is installed on the bottom side of the cavity return air duct 31, a flow equalizing membrane 37 is installed on the top of the cavity, a loading rod 38, a temperature and humidity sensor 40, a concentration sensor 35, a wind speed sensor 32, a cavity differential pressure sensor 39, and a safety grating 34 are installed on the inner wall of the cavity, an online particle monitoring point 75 and an online planktonic bacteria monitoring point 76 are installed inside the cavity, and a spray gun 77 is installed inside the isolator cavity.

[0052] Specifically, the return air high-efficiency filter 36 adopts a cylindrical H14 high-efficiency filter, which is installed at the bottom of the cavity body 41 and can be replaced online, replacing the common plate-type high-efficiency filter installed on the top of the cavity return air duct. Combined with the design of the integrated return air duct ① and the exhaust fan 12, it replaces the top exhaust component in the original general solution.

[0053] like Figure 6 As shown, the glass window assembly 33 includes a transparent tempered glass window 59, a hinge 60, a door lock 63, a door signal sensor 64, a glove port 61, an air seal 65 and a sterile transfer RTP system 62; the transparent tempered glass window 59 is connected to the cavity main frame 41 through the hinge 60; the transparent tempered glass window 59 is respectively provided with a hinge 60, a door lock 63, a door signal sensor 64, a glove port 61, an air seal 65 and a sterile transfer RTP system 62.

[0054] Specifically, the transparent tempered glass window 59 can be used to observe the internal situation of the equipment, the hinge 60 can rotate around the axis, and the door can be opened for maintenance and installation operations. The door lock 63 combined with the door signal 64 and the airtight seal 65 can realize the interlocking control of the door switch state to prevent the door from being opened by mistake during the production process. The glove port 61 can be used to perform necessary online operations inside the isolator during the production process. The aseptic transfer RTP system 62 can be used to aseptically transfer necessary items to the inside of the equipment during the production process.

[0055] Specifically, a 200-mesh polyurethane flow-equalizing membrane is installed on the top of the isolator cavity to achieve flow equalization of the filtered airflow entering the cavity. The wind speed sensor 32 is installed 150 to 300 mm below the flow-equalizing membrane to monitor the wind speed data inside the isolator cavity 3 in real time. The safety grating 34 is installed on the inner wall of the isolator main cavity 41 on both sides of the glass door by screws, with the center at the same height as the glove opening to detect glove operation, and the relevant signals are controlled in conjunction with supporting equipment to ensure personnel safety.

[0056] Specifically, the temperature and humidity sensor 40 is installed on the inner wall of the main cavity 41 to monitor the temperature and humidity inside the cavity in real time. The concentration sensor 35 is installed on the inner wall of the main cavity 41 to monitor the hydrogen peroxide concentration inside the cavity in real time; the return air high-efficiency filter / cavity differential pressure sensor 39 is connected to the sensor at both ends through the detection port inside the cavity to monitor the cavity pressure difference and the pressure difference at both ends of the return air high-efficiency filter in real time; the particle online monitoring point 75 is installed on the bottom plate of the supporting equipment 4 to monitor the inactive particles inside the isolator cavity 3 online; the floating bacteria online monitoring point 76 is installed on the bottom plate of the supporting equipment 4 to monitor the active particles inside the isolator cavity 3 online; the spray gun 77 is installed on the bottom plate of the supporting equipment 4, and the inside of the isolator cavity 3 can be cleaned through the glove port 61.

[0057] The isolator system of this integrated air conditioner has a compact design, a smaller overall size, and requires less space in the plant, making it more convenient to design the equipment plant. The air duct connecting the isolator and the air conditioner in the original technical route has been eliminated, reducing the design and construction workload of the plant air duct. The air conditioning system is above the isolator body and is closer, making the air conditioning more effective in regulating the temperature and humidity in the isolator. After the isolator and the air conditioner are integrated, they can share a set of power distribution cabinets and control cabinets, saving costs. The structural design is optimized, and the air conditioning power system and the exhaust power system in the original plan are taken into account by the air conditioning power system, reducing the energy consumption of the air conditioner. After integration, the equipment can be shipped as a whole, reducing the secondary installation and hoisting work on site of Party A; the original technical air conditioning base and installation platform have been eliminated, reducing the corresponding hoisting workload.

[0058] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions described in the above embodiments may still be modified, or some or all of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An isolator system with integrated air conditioning, characterized in that: The invention comprises an integrated air conditioner (1), an isolator static pressure box (2) and an isolator cavity (3); the isolator cavity (3) is connected to a supporting equipment bottom plate (4), the isolator cavity (3) is connected to the isolator static pressure box (2) at the top, and the integrated air conditioner (1) is arranged above the isolator static pressure box (2); the front side of the integrated air conditioner (1) is connected to an air conditioner maintenance cover plate (5); the front side of the isolator static pressure box (2) is connected to a static pressure box maintenance cover plate (6).

2. The isolator system of integrated air conditioning according to claim 1, characterized in that: The integrated air conditioner (1) comprises an air conditioning chamber main body shell (13), an exhaust fan (12) is arranged inside the air conditioning chamber main body shell (13), and the exhaust fan (12) is connected to the cavity return air duct (31); the lower end of the air conditioning chamber main body shell (13) is connected to the isolator static pressure box (2), and an air conditioning return air baffle assembly (14) is arranged at the connection point; a return air catalytic decomposition filter assembly (25) is arranged below the air conditioning return air baffle assembly (14); the right side wall of the air conditioning chamber main body shell (13) is connected to the cooling and heating coil assembly (19); The air conditioning air chamber main body shell (13) is connected to a fresh air duct (18) and an exhaust air duct (16); the fresh air duct (18) is provided with a fresh air electric air volume regulating butterfly valve (15); and the exhaust air duct (16) is provided with an exhaust air electric air volume regulating butterfly valve (17).

3. The isolator system of integrated air conditioning according to claim 2, characterized in that: The air conditioner return air baffle assembly (14) comprises a first pneumatic cylinder (43), a first pneumatic slider (44) is sleeved on the first pneumatic cylinder (43), a return air baffle (45) is connected to the first pneumatic slider (44), first sliding bearings (46) are arranged on both sides of the return air baffle (45); and a first position signal sensor (42) is connected to the first pneumatic slider (44).

4. The isolator system of integrated air conditioning according to claim 2, characterized in that: The refrigeration and heating coil assembly (19) comprises a refrigeration coil (66) and a heating coil (67); the refrigeration coil (66) is respectively connected to a first refrigeration / heating medium public engineering pipeline (68) and a first manual accessory group (70); the heating coil (67) is respectively connected to a second refrigeration / heating medium public engineering pipeline (72) and a second manual accessory group (73); the refrigeration electric proportional control valve (69) is installed on the first refrigeration / heating medium public engineering pipeline (68); and the heating electric proportional control valve (71) is installed on the second refrigeration / heating medium public engineering pipeline (72).

5. The isolator system of integrated air conditioning according to claim 2, characterized in that: The return air catalytic decomposition filter assembly (25) includes a filter fixing rail (47), a second pneumatic cylinder (48) is installed on the filter fixing rail (47), a second pneumatic slider (49) is connected to the second pneumatic cylinder (48), the second pneumatic slider (49) is connected to a filter mounting frame (50), a primary filter (51) and a decomposition filter (52) are connected inside the filter mounting frame (50); second sliding bearings are connected to both sides of the filter mounting frame (50), and the second sliding bearings are slidably connected to the filter fixing rail (47); and second position signal sensors are connected to both ends of the second pneumatic cylinder (48).

6. The isolator system of integrated air conditioning according to claim 2, characterized in that: The isolator static pressure box (2) includes a high-efficiency filter support plate (29) and a FFU circulation high-efficiency component (26); the high-efficiency filter support plate (29) is connected to the cavity main body frame (41), the lighting lamp (30) is installed on the bottom side of the high-efficiency filter support plate (29), the FFU circulation high-efficiency component (26) is installed on the high-efficiency filter support plate (29), the fresh air return air mixing channel (24) is installed on the top upper side of the FFU circulation high-efficiency component (26), the circulation high-efficiency PAO monitoring port (74) is installed on the outside of the side of the fresh air return air mixing channel (24), the sterilization evaporation plate component (28) is installed on the inner side wall of the fresh air return air mixing channel (24), the return air catalytic decomposition filter component (25) is installed below the return air port inside the fresh air return air mixing channel (24), and the static pressure box decorative plate (27) is installed on the outside of the static pressure box.

7. The isolator system of integrated air conditioning according to claim 6, characterized in that: The FFU circulation high-efficiency component (26) comprises an FFU circulation fan air chamber housing (53), a liquid tank circulation high-efficiency filter (56) with a filtration grade of H14 is pressed against the bottom edge of the FFU circulation fan air chamber housing (53) by six high-efficiency fixing blocks (57), a circulation fan support plate (55) is installed inside the FFU circulation fan air chamber housing (53), a circulation fan (54) is installed on the circulation fan support plate (55), and a fan speed regulator (58) is installed outside the FFU circulation fan air chamber housing (55).

8. The isolator system of integrated air conditioning according to claim 1, characterized in that: The isolator cavity (3) comprises a cavity main frame (41), a glass window assembly (33) is mounted on the cavity main frame (41), a cavity return air duct (31) is connected to the cavity main body and the integrated air conditioner (1), a return air high-efficiency filter (36) is mounted on the bottom of the cavity main frame (41), a return air high-efficiency inspection cover is mounted on the bottom side of the cavity return air duct (31), a flow equalizing membrane (37) is mounted on the cavity top, a loading hanging rod (38), a temperature and humidity sensor (40), a concentration sensor (35), a wind speed sensor (32), a cavity differential pressure sensor (39), and a safety grating (34) are mounted on the inner wall of the cavity, a particle online monitoring point (75) and a floating bacteria online monitoring point (76) are mounted inside the cavity, and a spray gun (77) is mounted inside the isolator cavity.

9. The isolator system of integrated air conditioning according to claim 8, characterized in that: The glass window assembly (33) comprises a transparent tempered glass window (59), a hinge (60), a door lock (63), a door signal sensor (64), a glove opening (61), an air seal (65) and a sterile transfer RTP system (62); the transparent tempered glass window (59) is connected to the cavity main body frame (41) through the hinge (60); the transparent tempered glass window (59) is respectively provided with the hinge (60), the door lock (63), the door signal sensor (64), the glove opening (61), the air seal (65) and the sterile transfer RTP system (62).

10. The isolator system of integrated air conditioning according to claim 4, characterized in that: A condensate water collection pan (20) is installed below the refrigeration coil (66), and the lowest point at the bottom of the condensate water collection pan (20) is connected to an external electric ball valve (22) of the equipment via a condensate water drainage pipe (21).

11. The isolator system of integrated air conditioning according to claim 2, characterized in that: The pressure relief valve (8) is installed on the top of the air conditioning chamber main body shell (13), and the decomposition filter assembly (9) is installed at the rear end of the pressure relief valve (8); The air pipe installation plate (11) and the aviation plug-in connector (10) are installed on the top of the air conditioning chamber main body shell (13), and the air conditioning maintenance cover plate (5) is installed on the side of the air conditioning chamber main body shell (13).

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