A multi-wavelength slab laser and anti-angiogenesis laser

Abstract

The present invention provides a multi-wavelength slab laser and a laser for anti-angiogenesis, which at least include a pump source, a laser crystal, a first cavity mirror, a second cavity mirror and a third cavity mirror, wherein the pump source is used to emit pump light; the laser crystal is used to release laser light after receiving the pump light, and the laser crystal is cut along 545nm, 577nm and 595nm cutting angles respectively; the first cavity mirror and the first crystal surface and the second crystal surface form a first resonant cavity for outputting 545nm laser; the second cavity mirror and the third crystal surface and the fourth crystal surface form a second resonant cavity for outputting 577nm laser; the third cavity mirror and the fifth crystal surface and the sixth crystal surface form a third resonant cavity for outputting 595nm laser; the multi-wavelength slab laser of the present invention can output three or six wavelengths of laser light, avoid the problem of multi-wavelength output mode competition, and is conducive to obtaining a highly integrated and low-cost laser, and has important application scenarios in the fields of biological detection, medical cosmetology, scar treatment, etc.

Description

Technical Field

[0001] The present invention relates to the field of laser technology, and in particular to a multi-wavelength slab laser and a laser for anti-angiogenesis. Background Art

[0002] Conventional treatments for vascular diseases include cryotherapy, high-frequency electrosurgical treatment, and isotope radiotherapy. These methods are prone to complications such as skin necrosis and scarring during treatment, which affect the appearance of the skin. In 1983, Anderson RR and Parrish JA proposed the concept of selective photothermal effect, namely "photothermal separation", which means: according to the biological characteristics of different tissues, select appropriate wavelengths, energy, and pulse duration to ensure effective treatment of vascular lesions while avoiding damage to surrounding normal tissues as much as possible. From the mechanism of action of laser treatment of vascular diseases, there is a large amount of oxygenated hemoglobin in vascular tissues, and the absorption peak of oxygenated hemoglobin is located near 555nm, 577nm, and 1000nm. When these oxygenated hemoglobins absorb a large amount of laser to produce thermal effects, they will be converted into a combination of methemoglobin and thrombus, thereby achieving the closure of diseased blood vessels. Diseased blood vessels are blood vessels that supply nutrients to diseased tissues. After the diseased blood vessels are closed, the diseased tissues cannot obtain nutrients and gradually necrotize. The use of lasers to treat scars is based on the same technical idea. The healing process of skin wounds is accompanied by excessive angiogenesis, which is closely related to the formation of pathological scars. Scar tissue usually contains more microvessels than the dermis of normal skin. When using lasers to treat scars, the microvessels inside the scar tissue can be closed, and the pathological scars cannot obtain nutrients through the microvessels and gradually necrotize. A large number of studies have also confirmed the effectiveness of anti-vascular therapy in inhibiting pathological scars.

[0003] The chemical formula of Yb or Nd-doped rare earth calcium oxyborate crystals is ReCa4O(BO3)3(Yb:ReCOB), where Re represents Y (yttrium) and lanthanide rare earth elements Gd and La. This type of crystal belongs to the space group Cm and point group m, and is a low-symmetry bicyclic crystal. It is easy to undergo electron-phonon coupling transitions, so that the energy of upper-level electrons is transferred to phonons. After multi-phonon oscillations, the fluorescence range obtained by energy level transitions can be greatly broadened. This discovery has achieved electron radiation amplification from 500nm to 550nm and phonon oscillation amplification from 560nm to 600nm in the laboratory, and has obtained practical laser products and put them on the market.

[0004] In current clinical practice, some diseased tissues are complex and the depths of diseased blood vessels vary. Simply using a single-wavelength laser makes it difficult to simultaneously seal blood vessels of different depths in the diseased tissue, resulting in poor treatment effects. Therefore, how to design a laser that can perform laser treatment on diseased tissues with many blood vessels of different depths is a technical problem that has not yet been solved in the prior art. Summary of the invention

[0005] Therefore, the technical problem to be solved by the present invention is to overcome the technical defect in the prior art that it is difficult to simultaneously seal blood vessels at different depths in the diseased tissue using a single wavelength laser, resulting in poor treatment effect, thereby providing a multi-wavelength slab laser that can simultaneously seal blood vessels at different depths in the diseased tissue.

[0006] The invention also provides a laser for anti-angiogenesis.

[0007] To this end, the present invention provides a multi-wavelength slab laser, comprising:

[0008] A pump source, used for emitting pump light;

[0009] A laser crystal, used for receiving pump light from the pump source and emitting laser light under stimulation;

[0010] The laser crystal is cut along a 545 nm type critical phase matching direction to form a first crystal plane and a second crystal plane that are opposite to each other;

[0011] The laser crystal is cut along a 577nm type I critical phase matching direction to form a third crystal plane and a fourth crystal plane that are opposite to each other;

[0012] The laser crystal is cut along a 595nm type I critical phase matching direction to form a fifth crystal plane and a sixth crystal plane that are opposite to each other;

[0013] The first crystal surface, the third crystal surface and the fifth crystal surface are coated with a dielectric film that is highly transparent to fundamental frequency light and doubled frequency light; the second crystal surface, the fourth crystal surface and the sixth crystal surface are coated with a dielectric film that is highly reflective or partially transparent to fundamental frequency light and highly transparent to doubled frequency light;

[0014] A first cavity mirror, arranged opposite to the first crystal surface, coated with a dielectric film having high reflection to fundamental frequency light and double frequency light, and forming a first resonant cavity with the first crystal surface and the second crystal surface;

[0015] A second cavity mirror is arranged opposite to the third crystal surface, coated with a dielectric film having high reflection to fundamental frequency light and double frequency light, and forms a second resonant cavity with the third crystal surface and the fourth crystal surface;

[0016] The third cavity mirror is arranged opposite to the fifth crystal surface, coated with a dielectric film with high reflection to fundamental frequency light and double frequency light, and forms a third resonant cavity with the fifth crystal surface and the sixth crystal surface.

[0017] As a preferred solution, the first crystal surface is coated with a 1090nm and 545nm dual-wavelength anti-reflection film, and the transmittance is greater than 99.5%; the second crystal surface is coated with a 1090nm high-reflection film and a 545nm anti-reflection film, and the transmittance is greater than 95%;

[0018] And / or, the third crystal surface is coated with a dual-wavelength anti-reflection film of 1154nm and 577nm, and the transmittance is greater than 99.5%; the fourth crystal surface is coated with a 1154nm high-reflection film and a 577nm anti-reflection film, and the transmittance is greater than 95%;

[0019] And / or, the fifth crystal surface is coated with a dual-wavelength anti-reflection film of 1190nm and 595nm, with a transmittance greater than 99.5%, and the sixth crystal surface is coated with a 1190nm high-reflection film and a 595nm anti-reflection film, with a transmittance greater than 95%.

[0020] As a preferred solution, the first crystal surface is coated with a 1090nm and 545nm dual-wavelength anti-reflection film with a transmittance greater than 99.5%; the second crystal surface is coated with a 1090nm partial transmission film with a transmittance of 1-80% and a 545nm anti-reflection film with a transmittance greater than 95%;

[0021] And / or, the third crystal surface is coated with a dual-wavelength anti-reflection film of 1154nm and 577nm, with a transmittance greater than 99.5%; the fourth crystal surface is coated with a 1154nm partial transmission film, a transmittance of 1-80% and a 577nm anti-reflection film, with a transmittance greater than 95%;

[0022] And / or, the fifth crystal surface is coated with a dual-wavelength anti-reflection film of 1190nm and 595nm with a transmittance greater than 99.5%, and the sixth crystal surface is coated with a 1190nm partial transmission film with a transmittance of 1-80% and a 595nm anti-reflection film with a transmittance greater than 95%.

[0023] As a preferred solution, the first cavity mirror is plated with a dielectric film that is highly reflective at 1090nm and 545nm, with a reflectivity greater than 99.9%, and can make the light in the two bands of 1000nm-1080nm and 1100nm-1200nm as highly transparent or partially transparent as possible;

[0024] And / or, the second cavity mirror is coated with a dielectric film that is highly reflective at 1154nm and 577nm, has a reflectivity greater than 99.9%, and can make the light in the two bands of 1000nm-1144nm and 1164nm-1200nm as highly transparent or partially transparent as possible;

[0025] And / or, the third cavity mirror is coated with a dielectric film which has high reflectivity at 1190nm and 595nm, a reflectivity greater than 99.9%, and can make the light in the 1000-1180nm band as highly transparent or partially transparent as possible.

[0026] As a preferred solution, it also includes:

[0027] A first birefringent filter is disposed between the first cavity mirror and the first crystal surface, and is used for selecting within the range of 1080nm-1120nm, making 1090nm highly reflective and other wavelengths of laser light highly transparent or partially transparent;

[0028] and / or, a second birefringent filter, disposed between the second cavity mirror and the third crystal surface, for selecting within the range of 1144nm-1164nm, making 1154nm highly reflective and other wavelengths of laser light highly transparent or partially transparent;

[0029] And / or, a third birefringent filter is arranged between the third cavity mirror and the fifth crystal surface, and is used for selecting within the range of 1180nm-1200nm, so that 1190nm is highly reflective and other wavelengths of laser light are highly transparent or partially transparent.

[0030] As a preferred embodiment, the laser crystal is an ytterbium-doped calcium borate oxygen salt crystal self-frequency doubling laser device, and the light-through surface is designed to be a bent shape, and the first crystal plane, the third crystal plane and the fifth crystal plane are formed in sequence on one side of the light-through surface, and the sixth crystal plane, the fourth crystal plane and the second crystal plane are formed in sequence on the other side of the light-through surface.

[0031] As a preferred solution, the laser crystal is cut into a plurality of pieces along the thickness direction, each piece is 0.5-1.5 mm thick, and each piece has the first crystal face, the second crystal face, the third crystal face, the fourth crystal face, the fifth crystal face, and the sixth crystal face; the spacing between two adjacent pieces of the laser crystal is 0.1-1 mm, which can allow the heat transfer fluid to pass through;

[0032] Preferably, each piece of the laser crystal has a thickness of 1 mm, a width of 10 mm, and a light transmission length of 10-20 mm.

[0033] As a preferred solution, there are two pump sources, which are respectively arranged on both sides of the laser crystal in the width direction;

[0034] The pump source is powered by a TTL circuit, and the power pulse width is 0.5-100ms, preferably 20-40ms.

[0035] As a preferred solution, the top and bottom surfaces of the laser crystal along the thickness direction are plated with gold, and the laser crystal is clamped by a copper heat sink by a brazing process, and the brazing material is a tin-bismuth alloy.

[0036] The present invention also provides an anti-angiogenesis laser for use in the treatment of skin vascular diseases and scar anti-angiogenesis, comprising the multi-wavelength slab laser as described in any one of the above items.

[0037] The technical solution provided by the present invention has the following advantages:

[0038] 1. The multi-wavelength slab laser of the present invention comprises at least a pump source, a laser crystal, a first cavity mirror, a second cavity mirror and a third cavity mirror, wherein the pump source is used to emit pump light; the laser crystal is used to release laser light after receiving the pump light, and the laser crystal is cut along a critical phase matching direction of 545nm to form a first crystal plane and a second crystal plane; cut along a critical phase matching direction of 577nm to form a third crystal plane and a fourth crystal plane; cut along a critical phase matching direction of 595nm to form a fifth crystal plane and a sixth crystal plane; the first cavity mirror, the first crystal plane and the second crystal plane form a first resonant cavity for outputting 545nm laser; the second cavity mirror, the third crystal plane and the fourth crystal plane form a second resonant cavity for outputting 577nm laser; the third cavity mirror, the fifth crystal plane and the sixth crystal plane form a third resonant cavity for outputting 595nm laser;

[0039] The multi-wavelength slab laser of the present invention can output lasers of three wavelengths, namely 545nm, 577nm and 595nm, by cutting the first crystal plane to the sixth crystal plane on the laser crystal, and matching the first cavity mirror, the second cavity mirror and the third cavity mirror, as well as a pump source. The problem of multi-wavelength output mode competition can be effectively avoided, which is conducive to obtaining a highly integrated, low-cost laser, and has important application scenarios in the fields of biological detection, medical cosmetology, etc. The multi-wavelength slab laser of the present invention has six wavelengths and three laser resonant cavities in one laser crystal, and one laser cavity forms 1-2 wavelengths. There is no mode competition problem, and the stable output of each wavelength can be guaranteed.

[0040] 2. The multi-wavelength slab laser of the present invention can further design the second crystal plane to partially transmit fundamental frequency light and have high transmittance to doubled frequency light, design the fourth crystal plane to partially transmit fundamental frequency light and have high transmittance to doubled frequency light, and design the sixth crystal plane to partially transmit fundamental frequency light and have high transmittance to doubled frequency light, so as to be able to output laser outputs of six wavelengths of 545nm, 577nm, 595nm, 1090nm, 1154nm and 1190nm;

[0041] The inventor believes that from the perspective of the location of vascular disease lesions and the depth of skin penetration of lasers of different wavelengths, the different absorption wavelengths of oxyhemoglobin and the tissue penetration depth of lasers of different wavelengths should be considered together. Shallow lesions should be treated with shorter wavelength lasers to achieve better treatment effects, while deep lesions require longer wavelength lasers to achieve significant treatment effects. For example, rosacea is more likely to occur in superficial blood vessels, while lower limb capillary dilation is more likely to occur in deep blood vessels.

[0042] The inventors also believe that although the absorption peak of oxygenated hemoglobin is not in the infrared region and its absorption rate in the 1000-1200nm range is very small, the light in this wavelength range penetrates the skin the deepest and can effectively act on deep blood vessels. When the energy is large enough, it can still effectively seal the blood vessels.

[0043] The multi-wavelength slab laser of the present invention can output 545nm, 577nm and 595nm lasers for the treatment of superficial blood vessels, and can also output 1090nm, 1154nm and 1190nm lasers for the treatment of deep blood vessels when treating diseased tissue with a large number of blood vessels at different depths. In other words, the multi-wavelength slab laser of the present invention can treat diseased tissue with both superficial and deep blood vessels, and can close blood vessels of different depths in the diseased tissue, thereby improving the treatment efficiency and treatment effect.

[0044] 3. In the multi-wavelength slab laser of the present invention, the first cavity mirror is plated with a dielectric film which has high reflectivity to 1090nm and 545nm, a reflectivity greater than 99.9%, and can make the two bands of light of 1000nm-1080nm and 1100nm-1200nm as highly transparent or partially transparent as possible. The above-mentioned setting of the first cavity mirror enables 1090nm and 545nm to oscillate as high as possible in the first resonant cavity, and makes the two bands of light of 1000nm-1080nm and 1100nm-1200nm as highly transparent or partially transparent as possible, thereby improving the intensity of the two wavelength lasers of 1090nm and 545nm as high as possible, and suppressing lasers of other wavelengths; the setting principles of the second cavity mirror and the third cavity mirror are the same, and their functions are not repeated here.

[0045] 4. The multi-wavelength slab laser of the present invention has a first birefringent filter arranged between the first cavity mirror and the first crystal surface, which is used to select within the range of 1080nm-1120nm, so that the 1090nm wavelength laser is highly transparent and the other wavelength lasers are highly reflected or partially reflected, so that the 1090nm wavelength laser can oscillate and strengthen in the first resonant cavity, and suppress the oscillation and enhancement of other wavelengths in the first resonant box, thereby enhancing the intensity of the 1090nm wavelength laser; a second birefringent filter is arranged between the second cavity mirror and the third crystal surface, and a third birefringent filter is arranged between the third cavity mirror and the fifth crystal surface, which play the same role, respectively used to make the 1154nm and 1190nm wavelength lasers oscillate and strengthen in the second resonant cavity and the third resonant cavity, and suppress the lasers of other wavelengths, thereby enhancing the intensity of the target wavelength laser.

[0046] 5. The multi-wavelength slab laser of the present invention, the laser crystal is a calcium oxyborate crystal self-doubling laser device doped with ytterbium ions, by sequentially forming the first crystal plane, the third crystal plane and the fifth crystal plane on one side of the laser crystal, and sequentially forming the sixth crystal plane, the fourth crystal plane and the second crystal plane on the other side, so that the target wavelength laser can be output from one or both sides.

[0047] 6. The multi-wavelength slab laser of the present invention cuts the laser crystal into several pieces along the thickness direction, each piece is 0.5-1.5 mm thick, each piece has the first crystal plane to the sixth crystal plane, and the interval distance between two adjacent laser crystals is 0.1-1 mm to allow the heat transfer fluid to pass through; by cutting the laser crystal into several pieces, the laser crystal can dissipate heat efficiently, thereby ensuring that the laser crystal can maintain normal operation when stimulated to release multiple wavelength lasers.

[0048] 7. The multi-wavelength slab laser of the present invention has two pump sources, which are respectively arranged on both sides of the width direction of the laser crystal, so that each laser crystal can be irradiated with pump light.

[0049] 8. The multi-wavelength slab laser of the present invention is gold-plated on the top and bottom surfaces along the thickness direction of the laser crystal, and is clamped by a copper heat sink using a brazing process. The brazing material is a tin-bismuth alloy, which can further dissipate heat for the laser crystal to maintain the normal working state of the laser crystal.

[0050] 9. The present invention also provides an anti-angiogenesis laser for the treatment of skin vascular diseases and scar anti-angiogenesis, comprising any of the above-mentioned multi-wavelength slab lasers. The anti-angiogenesis laser of the present invention has all the advantages of the above-mentioned multi-wavelength slab lasers because it adopts the above-mentioned multi-wavelength slab lasers. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] In order to more clearly illustrate the technical solutions in the prior art or the specific implementation manner of the present invention, the drawings used in the description of the prior art or the specific implementation manner are briefly introduced below.

[0052] Figure 1 It is a schematic diagram of the principle of the multi-wavelength slab laser of the present invention.

[0053] Figure 2 yes Figure 1 Schematic diagram of the laser crystal principle.

[0054] Figure numerals: 1, first cavity mirror; 2, second cavity mirror; 3, third cavity mirror; 4, first birefringent filter; 5, second birefringent filter; 6, third birefringent filter; 7, pump source; 8, laser crystal; 11, first crystal plane; 12, second crystal plane; 21, third crystal plane; 22, fourth crystal plane; 31, fifth crystal plane; 32, sixth crystal plane. DETAILED DESCRIPTION

[0055] In order to make those skilled in the art better understand the present solution, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work should fall within the scope of protection of the present application.

[0056] It should be noted that the terms "first", "second", etc. in the claims and description of the present application are used to distinguish similar objects, rather than to describe a specific order or sequence. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not limited to those steps or units clearly listed, but may also include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0057] In the present application, the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", "inside", "outside", "middle", "vertical", "horizontal", "lateral", "longitudinal" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings. These terms are mainly intended to better describe the present application and its embodiments, and are not intended to limit the indicated devices, elements or components to have a specific orientation, or to be constructed and operated in a specific orientation. In addition, in addition to being used to indicate orientation or positional relationships, some of the above terms may also be used to indicate other meanings. For example, the term "upper" may also be used to indicate a certain dependency or connection relationship in some cases. For those skilled in the art, the specific meanings of these terms in the present application can be understood according to the specific circumstances. In addition, the term "multiple" should mean two or more. It should be noted that the embodiments in the present application and the features in the embodiments may be combined with each other without conflict.

[0058] Explanation of terms: "high reflection", "high transmittance" and "partial reflection" in the present invention have well-known meanings in the art. "High reflection" means that the reflectivity of incident light of a specific wavelength or wavelength band is greater than 99%. "High transmittance" means that the transmittance of incident light of a specific wavelength or wavelength band is greater than 80%. "Partial transmittance" means that the transmittance of incident light of a specific wavelength or wavelength band is between 1% and 80%.

[0059] The present application will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0060] Example 1

[0061] This embodiment provides a multi-wavelength slab laser, such as Figure 1-2 As shown, it includes a first cavity mirror 1, a second cavity mirror 2, a third cavity mirror 3, a pump source 7 and a laser crystal 8. Among them:

[0062] The pump source 7 is used to emit pump light; the laser crystal 8 is used to receive the pump light from the pump source 7 and release laser light under stimulation; the laser crystal 8 is cut along a critical phase matching direction of 545nm to form a first crystal face 11 and a second crystal face 12 relative to each other; the laser crystal 8 is cut along a critical phase matching direction of 577nm to form a third crystal face 21 and a fourth crystal face 22 relative to each other; the laser crystal 8 is cut along a critical phase matching direction of 595nm to form a fifth crystal face 31 and a sixth crystal face 32 relative to each other; the first crystal face 11, the third crystal face 21 and the fifth crystal face 31 are plated with a dielectric film with high transmittance to fundamental frequency light and doubled frequency light; the second crystal face 12, the fourth crystal face 22 and the sixth crystal face 32 are plated with a dielectric film with high reflectance to fundamental frequency light and high transmittance to doubled frequency light;

[0063] The first cavity mirror 1 is arranged opposite to the first crystal surface 11, coated with a dielectric film with high reflection to the fundamental frequency light and the frequency doubled light, and forms a first resonant cavity with the first crystal surface 11 and the second crystal surface 12; the second cavity mirror 2 is arranged opposite to the third crystal surface 21, coated with a dielectric film with high reflection to the fundamental frequency light and the frequency doubled light, and forms a second resonant cavity with the third crystal surface 21 and the fourth crystal surface 22; the third cavity mirror 3 is arranged opposite to the fifth crystal surface 31, coated with a dielectric film with high reflection to the fundamental frequency light and the frequency doubled light, and forms a third resonant cavity with the fifth crystal surface 31 and the sixth crystal surface 32.

[0064] Specifically in this embodiment, the first crystal surface 11 is coated with a dual-wavelength anti-reflection film of 1090nm and 545nm, and the transmittance is greater than 99.5%; the second crystal surface 12 is coated with a 1090nm high-reflection film and a 545nm anti-reflection film, and the transmittance is greater than 95%; the third crystal surface 21 is coated with a dual-wavelength anti-reflection film of 1154nm and 577nm, and the transmittance is greater than 99.5%; the fourth crystal surface 22 is coated with a 1154nm high-reflection film and a 577nm anti-reflection film, and the transmittance is greater than 95%; the fifth crystal surface 31 is coated with a dual-wavelength anti-reflection film of 1190nm and 595nm, and the transmittance is greater than 99.5%, and the sixth crystal surface 32 is coated with a 1190nm high-reflection film and a 595nm anti-reflection film, and the transmittance is greater than 95%.

[0065] The multi-wavelength slab laser of this embodiment can output lasers of three wavelengths, namely 545nm, 577nm and 595nm, by cutting the first crystal plane 11 to the sixth crystal plane 32 on the laser crystal 8, and matching the first cavity mirror 1, the second cavity mirror 2 and the third cavity mirror 3, as well as the pump source 7. This can effectively avoid the problem of competition among multi-wavelength output modes, and is conducive to obtaining a highly integrated, low-cost laser, which has important application scenarios in the fields of biological detection, medical cosmetology, scar treatment, etc.

[0066] As a preferred design scheme, 6 wavelengths of laser can be output, and the specific settings are as follows: the first crystal surface 11 is coated with a dual-wavelength anti-reflection film of 1090nm and 545nm, and the transmittance is greater than 99.5%; the second crystal surface 12 is coated with a 1090nm partial transmission film, a transmittance of 1-80% and a 545nm anti-reflection film, and the transmittance is greater than 95%; the third crystal surface 21 is coated with a dual-wavelength anti-reflection film of 1154nm and 577nm, and the transmittance is greater than 99.5%; the fourth crystal surface 22 is coated with a 1154nm partial transmission film, a transmittance of 1-80% and a 577nm anti-reflection film, and the transmittance is greater than 95%; the fifth crystal surface 31 is coated with a dual-wavelength anti-reflection film of 1190nm and 595nm, and the transmittance is greater than 99.5%, and the sixth crystal surface 32 is coated with a 1190nm partial transmission film, a transmittance of 1-80% and a 595nm anti-reflection film, and the transmittance is greater than 95%.

[0067] The multi-wavelength slab laser of this embodiment can output 545nm, 577nm and 595nm lasers for the treatment of superficial blood vessels, and can also output 1090nm, 1154nm and 1190nm lasers for the treatment of deep blood vessels when treating diseased tissue with a large number of blood vessels of different depths. In other words, the multi-wavelength slab laser of this embodiment can treat diseased tissue with both superficial and deep blood vessels, and can seal blood vessels of different depths in the diseased tissue, thereby improving treatment efficiency and treatment effect.

[0068] As a preferred design scheme, it also includes: a first birefringent filter 4, arranged between the first cavity mirror 1 and the first crystal surface 11, for selecting 1090nm wavelength laser to pass through with high transmittance; a second birefringent filter 5, arranged between the second cavity mirror 2 and the third crystal surface 21, for selecting 1154nm wavelength laser to pass through with high transmittance; a third birefringent filter 6, arranged between the third cavity mirror 3 and the fifth crystal surface 31, for selecting 1190nm wavelength laser to pass through with high transmittance.

[0069] A first birefringent filter 4 is arranged between the first cavity mirror 1 and the first crystal surface 11, which is used for selecting within the range of 1080nm-1120nm, so that 1090nm is highly transparent, and other wavelengths of laser light are highly reflected or partially reflected, so that as many laser lights of 1090nm as possible are oscillated and enhanced in the first resonant cavity, and other wavelengths are suppressed from oscillating and enhanced in the first resonant cavity, thereby enhancing the intensity of the 1090nm wavelength laser light; a second birefringent filter 5 is arranged between the second cavity mirror 2 and the third crystal surface 21, and a third birefringent filter 6 is arranged between the third cavity mirror 3 and the fifth crystal surface 31, which play the same role, and are respectively used to make the 1154nm and 1190nm wavelength laser lights oscillate and enhance in the second resonant cavity and the third resonant cavity, and suppress the laser lights of other wavelengths, thereby enhancing the intensity of the target wavelength laser light.

[0070] In this embodiment, the first cavity mirror 1 is coated with a dielectric film that has high reflection at 1090nm and 545nm, a reflectivity greater than 99.9%, and can make the light in the two bands of 1000nm-1080nm and 1100nm-1200nm as highly transparent or partially transparent as possible; the second cavity mirror 2 is coated with a dielectric film that has high reflection at 1154nm and 577nm, a reflectivity greater than 99.9%, and can make the light in the two bands of 1000nm-1144nm and 1164nm-1200nm as highly transparent or partially transparent as possible; the third cavity mirror 3 is coated with a dielectric film that has high reflection at 1190nm and 595nm, a reflectivity greater than 99.9%, and can make the light in the band of 1000-1180nm as highly transparent or partially transparent as possible.

[0071] The above-mentioned setting of the first cavity mirror 1 makes 545nm and 1090nm oscillate as high as possible in the first resonant cavity, and makes the light in the two bands of 1000nm-1144nm and 1120nm-1200nm passing through the first birefringent filter 4 as highly transparent or partially transparent as possible, thereby improving the intensity of the two wavelengths of 1090nm and 545nm laser as high as possible and suppressing other wavelengths of laser; the setting principles of the second cavity mirror 2 and the third cavity mirror 3 are the same.

[0072] More specifically, the laser crystal 8 (ytterbium ion-doped calcium oxyborate crystal) has electronic transitions and phonon oscillations in the range of 500-600nm, and has a rich emission spectrum. In order to output a certain wavelength of laser light in a specific laser, it is necessary to effectively suppress other wavelengths of light. The laser is inserted with a first birefringent filter 4, a second birefringent filter 5, and a third birefringent filter 6, and a suitable cavity mirror coating is designed to suppress the stable output of the laser. For example, the first cavity mirror 1 ensures that the light in the two bands of 1000nm-1080nm and 1100nm-1200nm is as highly transmittance or partial transmission as possible while ensuring that the 1090nm and 545nm high-reflection films are coated and the reflectivity is greater than 99.9%; similarly, the second cavity mirror 2 ensures that the light in the two bands of 1000nm-1144nm and 1164nm-1200nm is as highly transmittance or partial transmission as possible while ensuring that the 1090nm and 545nm high-reflection films are coated and the reflectivity is greater than 99.9%; similarly, the third cavity mirror 3 ensures that the light in the band of 1000nm-1180nm is as highly transmittance or partial transmission as possible while ensuring that the 1190nm and 595nm high-reflection films are coated and the reflectivity is greater than 99.9%.

[0073] In this embodiment, the laser crystal 8 is an ytterbium ion-doped calcium oxygen borate crystal self-doubling laser device, and the light-through surface is designed to be a bent shape. The first crystal face 11, the third crystal face 21 and the fifth crystal face 31 are formed in sequence on one side of the light-through surface, and the sixth crystal face 32, the fourth crystal face 22 and the second crystal face 12 are formed in sequence on the other side of the light-through surface.

[0074] The cutting angle of the laser crystal 8 corresponding to the first crystal face 11 and the second crystal face 12 is 545nm, and the parameters are θ=115.7°, φ=36.2°; the cutting angle corresponding to the third crystal face 21 and the fourth crystal face 22 is 577nm, and the parameters are θ=115.7°, φ=32.3°, and the cutting angle corresponding to the fifth crystal face 31 and the sixth crystal face 32 is 595nm, and the parameters are θ=115.7°, φ=30.9°. The length of the laser crystal 8 in the passing direction is 10-20mm.

[0075] Furthermore, the laser crystal 8 is cut into several pieces along the thickness direction, each piece has a thickness of 0.5-1.5 mm, and each piece has the first crystal face 11, the second crystal face 12, the third crystal face 21, the fourth crystal face 22, the fifth crystal face 31 and the sixth crystal face 32; the interval between two adjacent laser crystals 8 is 0.1-1 mm, which can allow the heat transfer fluid to pass through; preferably, each piece of the laser crystal 8 has a thickness of 1 mm, a width of 10 mm, and a light transmission length of 10-20 mm. In this embodiment, the heat transfer fluid is pure water. By cutting the laser crystal 8 into several pieces, the heat dissipation for the laser crystal 8 can be efficiently dissipated, thereby ensuring that the laser crystal 8 can maintain normal operation when stimulated to release lasers of multiple wavelengths.

[0076] In this embodiment, there are two pump sources 7, which are respectively arranged on both sides of the laser crystal 8 in the width direction; the pump source 7 is powered by a TTL circuit, and the power supply pulse width is 0.5-100ms, preferably 20-40ms.

[0077] In addition, in this embodiment, the top and bottom surfaces of the laser crystal 8 along the thickness direction are gold-plated and clamped by a copper heat sink using a brazing process. The brazing material is a tin-bismuth alloy, which can further dissipate heat for the laser crystal 8 to maintain the normal working state of the laser crystal 8.

[0078] Example 2

[0079] This embodiment provides an anti-angiogenesis laser for the treatment of skin vascular diseases and scar anti-angiogenesis, which includes any multi-wavelength slab laser described in Example 1.

[0080] Anti-angiogenesis refers to a therapeutic strategy that intervenes in disease or abnormal tissue growth by inhibiting the formation of new blood vessels. There is usually such a relationship between angiogenesis and scar formation: in the early stages of wound healing, new blood vessels provide oxygen and nutrients for tissue repair, while in pathological scars (such as hypertrophic scars and keloids), the formation of new blood vessels may be overactive. These new blood vessels not only provide additional nutrients for scars, but also release pro-inflammatory factors and growth factors (such as VEGF, TGF-β), stimulating fibroblast proliferation and excessive collagen deposition, resulting in scar thickening and hardening.

[0081] The laser of this embodiment can inhibit angiogenesis, reduce blood supply to scars, block the nutritional source of scar tissue, and restrict its growth; it can regulate inflammation and fibrosis, inhibit pro-angiogenic factors (such as VEGF), reduce inflammatory mediators and collagen synthesis, and promote scar softening; it can also promote scar maturation and transform overproliferative scars into normal tissues.

[0082] The anti-angiogenesis laser of this embodiment adopts the above-mentioned multi-wavelength slab laser and thus has all the advantages of the above-mentioned multi-wavelength slab laser.

[0083] Obviously, the above embodiments are merely examples for clear explanation, and are not intended to limit the implementation methods. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from them are still within the protection scope of this innovative technical solution.

Claims

1. A multi-wavelength slab laser, characterized in that: include: A pump source (7) for emitting pump light; A laser crystal (8), used for receiving pump light from the pump source (7) and emitting laser light in response to stimulation; The laser crystal (8) is cut along a 545 nm type-I critical phase matching direction to form an opposite first crystal face (11) and a second crystal face (12); The laser crystal (8) is cut along a 577 nm type I critical phase matching direction to form a third crystal plane (21) and a fourth crystal plane (22) that are opposite to each other; The laser crystal (8) is cut along a 595 nm type I critical phase matching direction to form a fifth crystal plane (31) and a sixth crystal plane (32) that are opposite to each other; The first crystal surface (11), the third crystal surface (21) and the fifth crystal surface (31) are coated with a dielectric film that is highly transparent to fundamental frequency light and frequency doubled light; the second crystal surface (12), the fourth crystal surface (22) and the sixth crystal surface (32) are coated with a dielectric film that is highly reflective or partially transmissive to fundamental frequency light and highly transparent to frequency doubled light; A first cavity mirror (1) is arranged opposite to the first crystal surface (11), is coated with a dielectric film having high reflection to fundamental frequency light and double frequency light, and forms a first resonant cavity with the first crystal surface (11) and the second crystal surface (12); A second cavity mirror (2) is arranged opposite to the third crystal surface (21), coated with a dielectric film having high reflection to fundamental frequency light and frequency-doubled light, and forms a second resonant cavity with the third crystal surface (21) and the fourth crystal surface (22); The third cavity mirror (3) is arranged opposite to the fifth crystal surface (31), is coated with a dielectric film that is highly reflective to fundamental frequency light and frequency-doubled light, and forms a third resonant cavity with the fifth crystal surface (31) and the sixth crystal surface (32).

2. The multi-wavelength slab laser according to claim 1, characterized in that: The first crystal surface (11) is coated with a 1090nm and 545nm dual-wavelength anti-reflection film, and the transmittance is greater than 99.5%; the second crystal surface (12) is coated with a 1090nm high-reflection film and a 545nm anti-reflection film, and the transmittance is greater than 95%; And / or, the third crystal surface (21) is coated with a 1154nm and 577nm dual-wavelength anti-reflection film, and the transmittance is greater than 99.5%; the fourth crystal surface (22) is coated with a 1154nm high-reflection film and a 577nm anti-reflection film, and the transmittance is greater than 95%; And / or, the fifth crystal surface (31) is coated with a dual-wavelength anti-reflection film of 1190nm and 595nm, with a transmittance greater than 99.5%, and the sixth crystal surface (32) is coated with a 1190nm high-reflection film and a 595nm anti-reflection film, with a transmittance greater than 95%.

3. The multi-wavelength slab laser according to claim 1, characterized in that: The first crystal surface (11) is coated with a 1090nm and 545nm dual-wavelength anti-reflection film with a transmittance greater than 99.5%; the second crystal surface (12) is coated with a 1090nm partial transmission film with a transmittance of 1-80% and a 545nm anti-reflection film with a transmittance greater than 95%; And / or, the third crystal surface (21) is coated with a dual-wavelength anti-reflection film of 1154nm and 577nm, with a transmittance greater than 99.5%; the fourth crystal surface (22) is coated with a 1154nm partial transmission film, a transmittance of 1-80% and a 577nm anti-reflection film, with a transmittance greater than 95%; And / or, the fifth crystal surface (31) is coated with a dual-wavelength anti-reflection film of 1190nm and 595nm, with a transmittance greater than 99.5%, and the sixth crystal surface (32) is coated with a 1190nm partial transmission film, a transmittance of 1-80% and a 595nm anti-reflection film, with a transmittance greater than 95%.

4. The multi-wavelength slab laser according to any one of claims 1 to 3, characterized in that: The first cavity mirror (1) is coated with a dielectric film that is highly reflective at 1090nm and 545nm, has a reflectivity greater than 99.9%, and can make light in the two wavelength bands of 1000nm-1080nm and 1100nm-1200nm as highly transparent or partially transparent as possible; And / or, the second cavity mirror (2) is coated with a dielectric film that is highly reflective at 1154nm and 577nm, has a reflectivity greater than 99.9%, and can make light in the two wavelength bands of 1000nm-1144nm and 1164nm-1200nm as highly transparent or partially transparent as possible; And / or, the third cavity mirror (3) is coated with a dielectric film that is highly reflective at 1190nm and 595nm, has a reflectivity greater than 99.9%, and can make light in the 1000-1180nm band as highly transparent or partially transparent as possible.

5. The multi-wavelength slab laser according to claim 4, characterized in that: Also includes: A first birefringent filter (4) is arranged between the first cavity mirror (1) and the first crystal surface (11), and is used to select within the range of 1080nm-1120nm, so that 1090nm is highly transparent and other wavelengths of laser light are highly reflected or partially reflected; and / or, a second birefringent filter (5) disposed between the second cavity mirror (2) and the third crystal surface (21), for selecting within the range of 1144 nm to 1164 nm, so that 1154 nm is highly transparent and other wavelengths of laser light are highly reflected or partially reflected; And / or, a third birefringent filter (6) is arranged between the third cavity mirror (3) and the fifth crystal surface (31), and is used to select within the range of 1180nm-1200nm, so that 1190nm is highly transparent and other wavelengths of laser light are highly reflected or partially reflected.

6. The multi-wavelength slab laser according to claim 1, characterized in that: The laser crystal (8) is an ytterbium ion-doped calcium oxyborate crystal self-frequency doubling laser device, and the light-through surface is designed to be in a bent shape, and the first crystal surface (11), the third crystal surface (21) and the fifth crystal surface (31) are sequentially formed on one side of the light-through surface, and the sixth crystal surface (32), the fourth crystal surface (22) and the second crystal surface (12) are sequentially formed on the other side of the light-through surface.

7. The multi-wavelength slab laser according to claim 6, characterized in that: The laser crystal (8) is cut into a plurality of slices along the thickness direction, each slice having a thickness of 0.5-1.5 mm, and each slice having the first crystal face (11), the second crystal face (12), the third crystal face (21), the fourth crystal face (22), the fifth crystal face (31) and the sixth crystal face (32); the spacing between two adjacent slices of the laser crystal (8) is 0.1-1 mm, allowing a heat transfer fluid to pass through.

8. The multi-wavelength slab laser according to claim 7, characterized in that: Each piece of the laser crystal (8) has a thickness of 1 mm, a width of 10 mm, and a light transmission length of 10-20 mm.

9. The multi-wavelength slab laser according to claim 7, characterized in that: There are two pump sources (7), which are respectively arranged on both sides of the laser crystal (8) in the width direction; The pump source (7) is powered by a TTL circuit, and the power supply pulse width is 0.5-100 ms.

10. The multi-wavelength slab laser according to claim 9, characterized in that: The power supply pulse width of the pump source (7) is 20-40 ms.

11. The multi-wavelength slab laser according to claim 7 or 9, characterized in that: The top and bottom surfaces of the laser crystal (8) along the thickness direction are plated with gold and clamped by a copper heat sink using a brazing process, wherein the brazing material is a tin-bismuth alloy.

12. An anti-angiogenesis laser for the treatment of skin vascular diseases and scar anti-angiogenesis, characterized in that: The invention comprises the multi-wavelength slab laser according to any one of claims 1 to 11.

Images