The invention relates to a two-dimensional waveguide slot array antenna having a decoupling structure and a design method thereof and relates to a waveguide slot antenna. The antenna sequentially comprises a T-shaped power splitter main waveguide, a feed waveguide, coupling slots, a radiation waveguide, radiation slots and an open air cavity from down to up. The antenna has the decoupling structure, the open air cavity is added outside the radiation slot, the mutual coupling effect between the radiation slots is suppressed by optimizing the three-dimensional size of the air cavity, and antennabandwidth constraints of mutual coupling in large-scale arrays are effectively ameliorated. According to antenna bandwidth design requirements, the proper antenna feed network is designed, through antenna sub-arrays, the integral antenna is simplified into multiple sub-arrays, so antenna bandwidth is ameliorated, and design difficulty is reduced; the quantity of radiation slots and coupling slotsin series connection in each sub-array is small, a resonant array can be employed for design, namely a standing wave array form, and matching bandwidth and radiation bandwidth of the antenna sub-arrays are greatly improved through specifically employing the overloaded technology.