Traditional Chinese medicine composition, traditional Chinese medicine instant granule for treating oral lichen planus and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition, a traditional Chinese medicine instant granule and an application thereof for treating oral lichen planus. The traditional Chinese medicine composition comprises 8-10 parts of Pogostemon cablin, 6-8 parts of Dictamnus dasycarpus Turcz., 6-10 parts of Paeonia lactiflora Pall., 8-10 parts of Coix lacryma-jobi L., 6-10 parts of Citrus reticulata Blanco, 6-10 parts of Curcuma aromatica Salisb., 6-10 parts of Spatholobus suberectus Dunn, 2-5 parts of Coptis chinensis Franch., 7-10 parts of Talcum, 10-12 parts of Taraxacum mongolicum Hand.-Mazz., and 5-8 parts of Glycyrrhiza uralensis Fisch. The traditional Chinese medicine instant granule comprises the single-flavor traditional Chinese medicine formula granules in the above weight parts. The invention mainly soothes the liver, strengthens the spleen and promotes diuresis, supplemented by regulating qi and activating blood circulation, so as to soothe the liver depression, regulate qi movement, promote blood circulation and dredge collaterals, strengthen the spleen transportation, and normally transport and distribute water and dampness, thereby achieving the purpose of treating oral lichen planus of the type of liver depression, spleen deficiency and dampness preponderance.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and particularly to a traditional Chinese medicine composition, a traditional Chinese medicine instant granule for treating oral lichen planus, and their applications. Background Art

[0002] Oral lichen planus is a common chronic oral mucosal and skin disease, generally not contagious. Its onset is related to mental factors (such as fatigue, anxiety, tension), immune factors, endocrine factors, infectious factors, microcirculation disorder factors, trace element deficiencies, and certain systemic diseases (diabetes, infections, hypertension, digestive tract dysfunction). For some drugs such as methyldopa, atropine, chloroquine, dapsone, captopril, quinidine, etc., after taking certain traditional Chinese medicines, or when there are metal fillings or restorations in the oral cavity, changes similar to lichen planus may appear in the oral cavity, or the original lesions of lichen planus may be aggravated. After stopping the use of the suspected drugs or replacing the fillings and restorations, the lesions are significantly reduced or disappear.

[0003] The pathophysiological manifestations of oral lichen planus are as follows: incomplete epithelial keratinization, liquefaction degeneration of basal cells, and a dense lymphocyte infiltration band in the lamina propria. The granular layer is obvious, and most cases have acanthosis, with a few showing atrophy and thinning. The epithelial pegs are irregularly elongated, sometimes tapering at the lower end to form a serrated shape. The arrangement of basal cells is disordered, the basement membrane boundary is blurred, and obvious liquefaction degeneration of basal cells can form a subepithelial vesicle. Eosinophilic and red-stained colloid bodies can be seen in the spinous layer, basal layer, or lamina propria. Oral lichen planus is often classified into atrophic type, reticular type, and erosive type; the atrophic type is mostly seen on the dorsal surface of the tongue, presenting as a slightly light blue white plaque, slightly sunken, and the lingual papillae atrophy, making the lesion surface smooth. When it occurs in the gingiva, there is congestion or superficial erosion, and white patterns can be seen nearby; the reticular type consists of linear white or gray-white patterns formed by small papules. The patterns can form various shapes such as reticular, dendritic, annular, or semi-annular, and can also be presented as white plaque-like, occurring in any part of the oral mucosa, most commonly in the buccal area, and mostly symmetric on both sides; the erosive type often has erosion on the basis of congestion, so it is also called the congestive erosive type. There are white patterns or papules around the erosion, with obvious pain, and it often occurs in areas such as the buccal mucosa, lips, vestibular sulcus, retromolar area, and ventral surface of the tongue.

[0004] In traditional Chinese medicine theory, oral lichen planus belongs to the categories of "aphtha", "oral erosion", etc. Its onset is closely related to liver depression and spleen deficiency, internal excess of dampness, and emotional discomfort. For the western medicine treatment process of oral lichen planus, there are usually problems such as a single target, possible obvious side effects, and only focusing on eliminating symptoms without paying attention to prevention and rehabilitation conditioning. Summary of the Invention

[0005] In view of the problems of the prior art, the present invention provides a traditional Chinese medicine composition, a traditional Chinese medicine instant granule for treating oral lichen planus, and their applications. The traditional Chinese medicine composition and the traditional Chinese medicine instant granule mainly soothe the liver, strengthen the spleen and promote diuresis, supplemented by regulating qi and activating blood circulation, so that the stagnant liver qi is dredged, the qi mechanism is smooth, the blood vessels are unobstructed, the spleen transportation is healthy, and the water and dampness are normally transported and distributed, so as to achieve the purpose of treating oral lichen planus of the type of stagnant liver qi, weak spleen and excessive dampness. The whole formula is rigorously compatible, with monarch, minister, assistant and envoy herbs each performing their own functions. The effects of soothing the liver, strengthening the spleen, promoting diuresis, activating blood circulation and clearing heat complement each other. It not only targets the main pathogenesis of soothing the liver, strengthening the spleen and promoting diuresis, but also takes into account the pathological changes of blood stasis and stagnant heat, reflecting the overall concept of traditional Chinese medicine in treating oral lichen planus and the principle of syndrome differentiation and treatment.

[0006] The present invention provides the following solution: a traditional Chinese medicine composition for treating oral lichen planus, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0007] 8-10 parts of Pogostemon cablin, 6-8 parts of Dictamnus dasycarpus Turcz., 6-10 parts of Paeonia lactiflora Pall., 8-10 parts of Coix lacryma-jobi L., 6-10 parts of Citrus reticulata Blanco, 6-10 parts of Curcuma aromatica Salisb., 6-10 parts of Spatholobus suberectus Dunn, 2-5 parts of Coptis chinensis Franch., 7-10 parts of Talc, 10-12 parts of Taraxacum mongolicum Hand.-Mazz., 5-8 parts of Glycyrrhiza uralensis Fisch.

[0008] The traditional Chinese medicine composition for treating oral lichen planus provided by the present invention has the following beneficial effects:

[0009] 1. Overall conditioning: Western medicine often treats local symptoms or a single cause. The traditional Chinese medicine composition provided by the present invention is based on the overall concept of traditional Chinese medicine, starting from the whole human body, considering factors such as the patient's constitution and zang-fu functions, and regulating the body's yin-yang balance, qi and blood circulation, and zang-fu functions to improve the overall internal environment for treatment purposes. It not only eliminates local symptoms but also adjusts the internal states such as dampness and heat in the body, reducing the possibility of recurrence.

[0010] 2. Multi-target action: Western medicine usually acts on a single target. The traditional Chinese medicine composition provided by the present invention contains multiple traditional Chinese medicine components and can act on multiple pathological links and targets. When treating related diseases, multiple components simultaneously play roles in multiple aspects such as inflammatory response, immune regulation, and cell metabolism, synergistically taking effect and more comprehensively improving the condition.

[0011] 3. Relatively few side effects: Some Western medicines may have obvious side effects during treatment. For example, long-term use of hormonal drugs may cause problems such as endocrine disorders. The traditional Chinese medicine composition provided by the present invention is composed of natural traditional Chinese medicines and has relatively few side effects under reasonable medication conditions.

[0012] 4. Personalized treatment: Western medicine often adopts standardized treatment plans, while the traditional Chinese medicine composition provided by the present invention conducts syndrome differentiation and treatment based on the specific symptoms, signs, tongue manifestations, pulse conditions, etc. of the patient, flexibly adjusts the drug composition and dosage of the prescription, realizes personalized treatment, and better adapts to the disease conditions and physical needs of different patients.

[0013] 5. Emphasis on prevention and rehabilitation: Western medicine treatment mainly focuses on eliminating symptoms. The traditional Chinese medicine composition provided by the present invention not only can treat diseases, but also emphasizes the prevention and rehabilitation conditioning of diseases. After the treatment of diseases, through the conditioning of traditional Chinese medicine, the physical fitness of patients can be enhanced, the resistance and repair ability of the body can be improved, the physical recovery can be promoted, the recurrence of diseases can be prevented, and the patients can be helped to recover to a better health state.

[0014] 6. Significant curative effect: The traditional Chinese medicine composition provided by the present invention mainly soothes the liver, strengthens the spleen and promotes diuresis, supplemented by regulating qi and activating blood circulation, so that the stagnated liver qi is dredged, the qi mechanism is smooth, the blood vessels are unobstructed, the spleen transportation is healthy, and the water and dampness are normally transported and distributed, so as to achieve the purpose of treating oral lichen planus of the type of stagnated liver qi, spleen deficiency and excessive dampness. The whole prescription is rigorously formulated, with monarch, minister, assistant and envoy herbs each performing its own functions. The effects of soothing the liver, strengthening the spleen, promoting diuresis, activating blood circulation and clearing heat complement each other. It not only targets the main pathogenesis of soothing the liver, strengthening the spleen and promoting diuresis, but also takes into account the pathological changes of blood stasis and stagnant heat, reflecting the overall concept and principle of syndrome differentiation and treatment in traditional Chinese medicine for treating oral lichen planus, paying attention to the mutual compatibility of drugs and the relationship of mutual promotion and restraint between zang-fu organs, and having a significant curative effect.

[0015] In addition, the traditional Chinese medicine composition for treating oral lichen planus provided by the present invention may also have the following additional technical features:

[0016] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

[0017] Patchouli 10 parts, Dictamnus dasycarpus Turcz. 8 parts, White Peony Root 10 parts, Coix Seed 10 parts, Tangerine Peel 6 parts, Curcuma aromatica Salisb. 6 parts, Suberect Spatholobus Stem 8 parts, Coptis chinensis Franch. 2 parts, Talc 10 parts, Dandelion 10 parts, Licorice Root 6 parts.

[0018] The present invention also provides an application of the above traditional Chinese medicine composition for treating oral lichen planus in the preparation of drugs for treating oral lichen planus.

[0019] The present invention also provides a traditional Chinese medicine instant granule for treating oral lichen planus, and the traditional Chinese medicine instant granule comprises the following single-herb formula granules in parts by weight:

[0020] Patchouli 8 - 10 parts, Dictamnus dasycarpus Turcz. 6 - 8 parts, White Peony Root 6 - 10 parts, Coix Seed 8 - 10 parts, Tangerine Peel 6 - 10 parts, Curcuma aromatica Salisb. 6 - 10 parts, Suberect Spatholobus Stem 6 - 10 parts, Coptis chinensis Franch. 2 - 5 parts, Talc 7 - 10 parts, Dandelion 10 - 12 parts, Licorice Root 5 - 8 parts.

[0021] In addition, the instant granules of traditional Chinese medicine for treating oral lichen planus provided by the present invention may further have the following additional technical features:

[0022] Preferably, the instant granules of traditional Chinese medicine comprise single-flavor traditional Chinese medicine formula granules in the following parts by weight:

[0023] 10 parts of Pogostemon cablin (Blanco) Benth., 8 parts of Dictamnus dasycarpus Turcz., 10 parts of Paeonia lactiflora Pall., 10 parts of Coix lacryma-jobi L., 6 parts of Citrus reticulata Blanco, 6 parts of Curcuma aromatica Salisb., 8 parts of Spatholobus suberectus Dunn, 2 parts of Coptis chinensis Franch., 10 parts of Talc, 10 parts of Taraxacum mongolicum Hand.-Mazz., 6 parts of Glycyrrhiza uralensis Fisch.

[0024] The present invention also provides an application of the above instant granules of traditional Chinese medicine for treating oral lichen planus in the preparation of a medicament for treating oral lichen planus.

[0025] In view of the pathology of oral lichen planus, the present invention adopts the treatment methods of soothing the liver, strengthening the spleen, promoting diuresis to eliminate dampness, activating blood circulation, and clearing heat. The treatment mechanism of the traditional Chinese medicine of the present invention is as follows:

[0026] Taking Dictamnus dasycarpus Turcz. and Pogostemon cablin (Blanco) Benth. as the monarch drugs, Dictamnus dasycarpus Turcz. is bitter and cold in nature and is good at clearing heat and removing dampness and detoxifying. Pogostemon cablin (Blanco) Benth. is pungent and warm in nature and is good at resolving dampness and regulating the middle-jiao, and at the same time can strengthen the spleen earth and restore the qi mechanism of the spleen and stomach. The two are used in combination. One is cold and the other is warm. While jointly exerting the effect of removing dampness, they also strengthen the spleen to prevent the recurrence of dampness due to spleen deficiency and failure of transportation.

[0027] Taking Paeonia lactiflora Pall., Coix lacryma-jobi L., and Citrus reticulata Blanco as the minister drugs, Paeonia lactiflora Pall. is slightly cold and sour in taste, can astringe the liver yin and nourish the liver and soften the liver. Together with Pogostemon cablin (Blanco) Benth., it can prevent the liver depression from attacking the spleen by softening the liver and strengthen the effect of Pogostemon cablin (Blanco) Benth. in strengthening the spleen. Coix lacryma-jobi L. is cool and sweet and bland in taste, has the effects of promoting diuresis to eliminate dampness, strengthening the spleen and stopping diarrhea, and dispelling impediment and discharging pus. It can not only strengthen the dampness-removing functions of Dictamnus dasycarpus Turcz. and Pogostemon cablin (Blanco) Benth., but also jointly with Pogostemon cablin (Blanco) Benth. play the role of strengthening the spleen and invigorating the spleen. Citrus reticulata Blanco is warm in nature and pungent and bitter in taste, and is good at soothing the liver and strengthening the spleen and regulating qi. When the liver is soothed, qi moves, when qi moves, dampness is removed, and when dampness is removed, lichen disappears.

[0028] Taking Curcuma aromatica Salisb., Spatholobus suberectus Dunn, Coptis chinensis Franch., Taraxacum mongolicum Hand.-Mazz., and Talc as the assistant drugs, Curcuma aromatica Salisb. is cold in nature and pungent and bitter in taste, has the effects of promoting qi circulation and relieving depression, promoting blood circulation and relieving pain, and can strengthen the effects of Paeonia lactiflora Pall. in soothing the liver and regulating qi and promoting blood circulation and nourishing blood. Spatholobus suberectus Dunn is warm, bitter, and sweet in nature and has the effect of promoting blood circulation and nourishing blood. It is used in combination with Curcuma aromatica Salisb. to jointly enhance the power of promoting blood circulation and relieving pain of the prescription. Oral lichen planus is prone to stagnation and transformation into heat after a long illness. Coptis chinensis Franch. is a bitter and cold drug, and Taraxacum mongolicum Hand.-Mazz. is a sweet and cold drug, both of which have the effect of clearing heat and detoxifying. Matched with Dictamnus dasycarpus Turcz., they enhance the heat-clearing power of the monarch drug. Talc is cold in nature and sweet and bland in taste, and its effect of clearing heat and promoting diuresis helps the dampness and heat to go out through urine, so that the dampness and heat pathogens have a way out.

[0029] Taking Glycyrrhiza uralensis Fisch. as the guiding drug, Glycyrrhiza uralensis Fisch. is sweet and flat in nature, can harmonize all the drugs, alleviate the drug properties, and reduce the possible adverse reactions of the drugs.

[0030] Meanwhile, the single-herb formula granules used in the instant Chinese medicine quick-dissolving granules are a series of pure Chinese medicine products refined from traditional Chinese medicine decoction pieces that conform to the processing specifications through extraction, concentration, separation, drying, granulation, and packaging by modern pharmaceutical technologies.

[0031] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0033] Figure 1 It is a comparison diagram before and after treatment of Patient 1 provided by the embodiment of the present invention;

[0034] Figure 2 It is a comparison diagram before and after treatment of Patient 2 provided by the embodiment of the present invention;

[0035] Figure 3 It is a comparison diagram before and after treatment of Patient 3 provided by the embodiment of the present invention;

[0036] Figure 4 It is a comparison diagram before and after treatment of Patient 4 provided by the embodiment of the present invention;

[0037] Figure 5 It is a comparison diagram before and after treatment of Patient 5 provided by the embodiment of the present invention.

[0038] The following will further illustrate the embodiments of the present invention with reference to the drawings. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0039] To make the objectives, features, and advantages of the present invention more apparent and understandable, the following will provide a detailed description of the specific embodiments of the present invention in conjunction with the embodiments. Several embodiments of the present invention are given in the embodiments. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0040] Embodiment 1

[0041] In Example 1 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 8 parts, Paeonia lactiflora Pall. 10 parts, Coix lacryma-jobi L. 10 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 6 parts, Spatholobus suberectus Dunn 8 parts, Coptis chinensis Franch. 2 parts, Talc 10 parts, Taraxacum mongolicum Hand.-Mazz. 10 parts, Glycyrrhiza uralensis Fisch. 6 parts.

[0042] Example 2

[0043] In Example 2 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 8 parts, Paeonia lactiflora Pall. 8 parts, Coix lacryma-jobi L. 8 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 10 parts, Spatholobus suberectus Dunn 8 parts, Coptis chinensis Franch. 2 parts, Talc 8 parts, Taraxacum mongolicum Hand.-Mazz. 12 parts, Glycyrrhiza uralensis Fisch. 6 parts.

[0044] Example 3

[0045] In Example 3 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 6 parts, Paeonia lactiflora Pall. 10 parts, Coix lacryma-jobi L. 10 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 10 parts, Spatholobus suberectus Dunn 6 parts, Coptis chinensis Franch. 2 parts, Talc 7 parts, Taraxacum mongolicum Hand.-Mazz. 12 parts, Glycyrrhiza uralensis Fisch. 6 parts.

[0046] Example 4

[0047] In Example 4 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 6 parts, Paeonia lactiflora Pall. 10 parts, Coix lacryma-jobi L. 8 parts, Citrus reticulata Blanco 10 parts, Curcuma aromatica Salisb. 10 parts, Spatholobus suberectus Dunn 10 parts, Coptis chinensis Franch. 2 parts, Talc 7 parts, Taraxacum mongolicum Hand.-Mazz. 10 parts, Glycyrrhiza uralensis Fisch. 6 parts.

[0048] Example 5

[0049] In Example 5 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 8 parts, Paeonia lactiflora Pall. 6 parts, Coix lacryma-jobi L. 8 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 6 parts, Spatholobus suberectus Dunn 8 parts, Coptis chinensis Franch. 5 parts, Talc 8 parts, Taraxacum mongolicum Hand.-Mazz. 12 parts, Glycyrrhiza uralensis Fisch. 6 parts.

[0050] Example 6

[0051] In Example 6 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 8 parts, Paeonia lactiflora Pall. 6 parts, Coix lacryma-jobi L. 10 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 6 parts, Spatholobus suberectus Dunn 8 parts, Coptis chinensis Franch. 2 parts, Talc 8 parts, Taraxacum mongolicum Hand.-Mazz. 12 parts, Glycyrrhiza uralensis Fisch. 5 parts.

[0052] Example 7

[0053] In Example 7 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: Pogostemon cablin 8 parts, Dictamnus dasycarpus Turcz. 8 parts, Paeonia lactiflora Pall. 8 parts, Coix lacryma-jobi L. 10 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 8 parts, Spatholobus suberectus Dunn 8 parts, Coptis chinensis Franch. 2 parts, Talc 8 parts, Taraxacum mongolicum Hand.-Mazz. 12 parts, Glycyrrhiza uralensis Fisch. 8 parts.

[0054] Example 8

[0055] In Example 8 of the present invention, a traditional Chinese medicine composition for treating oral lichen planus is provided. The traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: Pogostemon cablin 10 parts, Dictamnus dasycarpus Turcz. 8 parts, Paeonia lactiflora Pall. 10 parts, Coix lacryma-jobi L. 10 parts, Citrus reticulata Blanco 6 parts, Curcuma aromatica Salisb. 6 parts, Spatholobus suberectus Dunn 8 parts, Coptis chinensis Franch. 2 parts, Talc 10 parts, Taraxacum mongolicum Hand.-Mazz. 10 parts, Glycyrrhiza uralensis Fisch. 6 parts.

[0056] Example 9

[0057] In Example 9 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises the following single-flavor traditional Chinese medicine formula granules in grams: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 10g, Taraxacum mongolicum Hand.-Mazz. 10g, Glycyrrhiza uralensis Fisch. 6g.

[0058] Example 10

[0059] In Example 10 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises the following single-flavor traditional Chinese medicine formula granules in grams: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 8g, Coix lacryma-jobi L. 8g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 10g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 8g, Taraxacum mongolicum Hand.-Mazz. 12g, Glycyrrhiza uralensis Fisch. 6g.

[0060] Example 11

[0061] In Example 11 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises the following single-flavor traditional Chinese medicine formula granules in grams: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 6g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 10g, Spatholobus suberectus Dunn 6g, Coptis chinensis Franch. 2g, Talc 7g, Taraxacum mongolicum Hand.-Mazz. 12g, Glycyrrhiza uralensis Fisch. 6g.

[0062] Example 12

[0063] In Example 12 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises single-flavor traditional Chinese medicine formula granules with the following weights: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 6g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 8g, Citrus reticulata Blanco 10g, Curcuma aromatica Salisb. 10g, Spatholobus suberectus Dunn 10g, Coptis chinensis Franch. 2g, Talc 7g, Taraxacum mongolicum Hand.-Mazz. 10g, Glycyrrhiza uralensis Fisch. 6g.

[0064] Example 13

[0065] In Example 13 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises single-flavor traditional Chinese medicine formula granules with the following weights: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 6g, Coix lacryma-jobi L. 8g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 5g, Talc 8g, Taraxacum mongolicum Hand.-Mazz. 12g, Glycyrrhiza uralensis Fisch. 6g.

[0066] Example 14

[0067] In Example 14 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises single-flavor traditional Chinese medicine formula granules with the following weights: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 6g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 8g, Taraxacum mongolicum Hand.-Mazz. 12g, Glycyrrhiza uralensis Fisch. 6g.

[0068] Example 15

[0069] In Example 15 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises single-flavor traditional Chinese medicine formula granules with the following weights: Pogostemon cablin 8g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 8g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 8g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 8g, Taraxacum mongolicum Hand.-Mazz. 12g, Glycyrrhiza uralensis Fisch. 6g.

[0070] Example 16

[0071] In Example 16 of the present invention, a traditional Chinese medicine instant granule for treating oral lichen planus is provided. The traditional Chinese medicine instant granule comprises single-flavor traditional Chinese medicine formula granules with the following weights: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 10g, Taraxacum mongolicum Hand.-Mazz. 10g, Glycyrrhiza uralensis Fisch. 6g.

[0072] In another embodiment of the present invention, an application of the traditional Chinese medicine composition for treating oral lichen planus according to any one of Examples 1-8 in the preparation of a drug for treating oral lichen planus is further provided.

[0073] In another embodiment of the present invention, there is also provided an application of the instant-prepared traditional Chinese medicine granules for treating oral lichen planus according to any one of Embodiments 9-16 in the preparation of drugs for treating oral lichen planus.

[0074] In the above embodiments of the present invention, the raw medicinal materials are all commonly used Chinese medicinal materials available on the market, and the single-flavor traditional Chinese medicine formula granules are all commonly used traditional Chinese medicine granules available on the market.

[0075] The beneficial effects of the instant-prepared traditional Chinese medicine granules for treating oral lichen planus provided in the above embodiments will be further illustrated by specific test examples below. For convenience, the instant-prepared traditional Chinese medicine granules for treating oral lichen planus will be hereinafter simply referred to as Xiaoxianyin:

[0076] The core pathogenesis of oral lichen planus: liver depression and spleen weakness, internal exuberance of damp pathogen.

[0077] The traditional Chinese medicine diagnostic criteria: The diagnostic criteria for oral lichen planus of the type of liver depression, spleen weakness and damp exuberance refer to "Oral Mucosal Diseases" and "Traditional Chinese Medicine Diagnosis", and are formulated in combination with clinical experience.

[0078] The symptoms of oral lichen planus:

[0079] Main symptoms: a1) White keratinized stripes or plaques are seen on the oral mucosa, accompanied by hyperemia, redness or erosion of the surrounding mucosa, with a burning or painful sensation; a2) Usually having a preference for fatty, sweet and thick-flavored foods.

[0080] Subsidiary symptoms: b1) Dry mouth, bitter taste in the mouth or sticky feeling in the mouth; b2) Irritability or depression; b3) Abdominal distension and fullness.

[0081] Tongue and pulse symptoms: The tongue is red or pale, may have tooth marks, the tongue coating is yellow and greasy or white and greasy, and the pulse is string-like and soggy, or string-like and thin.

[0082] Clinical diagnosis: Meeting the clinical manifestations of oral lichen planus, having 1 or more main symptoms, 1 or more subsidiary symptoms, and meeting the tongue and pulse symptoms can be diagnosed.

[0083] Effective cases of Xiaoxianyin in treating oral lichen planus:

[0084] I. Patient 1, male, 51 years old, initial diagnosis time: January 15, 2024.

[0085] Chief complaint: Repeated pain in the left buccal mucosa for more than 3 years, aggravated for 1 month.

[0086] Present Illness History: Three years ago, due to irregular diet and a preference for spicy foods, the patient often had oral ulcers that were persistent, did not heal for a long time, and recurred after healing. The patient visited a local hospital, where Western medicine was taken orally and the topical drug Xileisan was used for treatment, but the treatment effect was not good. One month ago, after eating spicy food, the oral mucosa pain occurred again, and the symptoms did not relieve after taking oral medications. Now the patient comes for treatment. Symptoms include: The patient complains of pain and discomfort in the oral mucosa, accompanied by a burning sensation or pain, dry mouth, bitter taste in the mouth, irritability, short and red urine, sticky stools, abdominal fullness and distension, red tongue, yellow and greasy tongue coating, and taut, slippery pulse.

[0087] Examination: A 15*15mm 2 white keratinized stripe can be seen on the left lingual ventral surface. The center of the lesion may be accompanied by congestion, and the texture is soft and thick. For details, please refer to Figure 1 the patient image before treatment in

[0088] Past Medical History: The patient is in good health.

[0089] Traditional Chinese Medicine Diagnosis: Oral erosion, syndrome of liver depression, spleen deficiency and dampness preponderance.

[0090] Western Medicine Diagnosis: Oral lichen planus.

[0091] Treatment Method: Soothe the liver and strengthen the spleen, clear heat and promote diuresis.

[0092] Chinese Medicine for the First Treatment: Xiaoxianyin, using the Xiaoxianyin described in Example 9, specifically as follows: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 10g, Taraxacum mongolicum Hand.-Mazz. 10g, Glycyrrhiza uralensis Fisch. 6g, 7 doses, taken with water, one dose per day, divided into two times.

[0093] Follow-up Visit Time: January 29, 2024.

[0094] After the first treatment, that is, after two courses of treatment, the patient complains that the pain in the oral mucosa has decreased, and there is occasional dry mouth, bitter taste in the mouth, slightly yellow urine, sticky stools, and the feeling of abdominal distension has decreased. The tongue is red, the tongue coating is yellow, and the pulse is slippery;

[0095] Examination: A 10*7mm 2 white keratinized stripe can be seen on the left lingual ventral surface, and the texture is light. For details, please refer to Figure 1 the patient image after the first treatment in

[0096] Chinese Medicine for the Second Treatment: Xiaoxianyin, using the Xiaoxianyin described in Example 16, specifically as follows: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 10g, Taraxacum mongolicum Hand.-Mazz. 10g, Glycyrrhiza uralensis Fisch. 6g, 7 doses, taken with water, one dose per day, divided into two times.

[0097] After the second treatment, the patient reported no pain in the oral mucosa, occasional dry mouth, no bitter taste, normal urination, sticky stool, good sleep, no abdominal distension, red tongue, yellow tongue coating, and slippery pulse;

[0098] Examination: 8*6mm can be seen on the left side of the tongue 2 White keratinized stripes, light texture, please refer to Figure 1 Image of the patient after the second treatment.

[0099] 2. Patient 2, female, 47 years old, first visit date: January 15, 2024.

[0100] Chief complaint: Recurrent oral mucosal erosion and pain for more than 2 years, aggravated for 2 weeks.

[0101] Current medical history: The patient developed oral mucosal ulcers without obvious cause 2 years ago. He felt obvious pain when eating spicy and irritating food, and the symptoms recurred. He went to a local clinic for treatment and was given oral treatment with vitamin B and other drugs. The symptoms were slightly relieved. 2 weeks ago, he often stayed up late at work, which aggravated the above symptoms. The symptoms did not improve after taking oral drugs on his own. He came to the clinic for treatment. Symptoms: The patient had pain in the right cheek mucosa, mainly with a burning sensation, grid-like white stripes on the oral mucosa, slight congestion of the mucosa at the lesion site accompanied by dry mouth and bitter taste, irritability, general heaviness, short and red urine, sticky stools, poor sleep, red tongue, yellow and greasy tongue coating, tooth marks on the edge of the tongue, and a slippery and rapid pulse.

[0102] Examination: Congestion of the cheek mucosa can be seen on the right side, 25*10mm 2 White keratinized stripes, light texture, please refer to Figure 2 Image of the patient before treatment.

[0103] Menstrual history: menarche at the age of 14, early menstruation, history of dysmenorrhea, small blood clots, dark red color, normal amount.

[0104] Past history: in good health.

[0105] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0106] Western medicine diagnosis: oral lichen planus.

[0107] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0108] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 10, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 8g, Coix Seed 8g, Tangerine Peel 6g, Curcuma 10g, Millettia 8g, Coptis 2g, Talcum 8g, Taraxacum 12g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0109] Follow-up date: January 22, 2024.

[0110] After the first treatment, the patient reported that the pain in the buccal mucosa on the right side had decreased. There was occasional dry mouth and bitter taste, which was more obvious in the morning when waking up. Bowel movements and urination were normal, but the patient had poor sleep. The tongue was red, the tongue coating was yellow, and the pulse was slippery.

[0111] Examination: The buccal mucosa on the right side was congested, and white keratinized stripes measuring 15*12 mm could be seen. 2 The texture was light. For specific details, refer to Figure 2 the image of the patient after the first treatment in

[0112] Chinese medicine for the second treatment: Xiaoxianyin, using Xiaoxianyin as described in Example 9, specifically as follows: Pogostemon cablin 10g, Dictamnus dasycarpus Turcz. 8g, Paeonia lactiflora Pall. 10g, Coix lacryma-jobi L. 10g, Citrus reticulata Blanco 6g, Curcuma aromatica Salisb. 6g, Spatholobus suberectus Dunn 8g, Coptis chinensis Franch. 2g, Talc 10g, Taraxacum mongolicum Hand.-Mazz. 10g, Glycyrrhiza uralensis Fisch. 6g. Take 7 doses, decoct with water, one dose per day, taken in two divided doses.

[0113] After the second treatment, the patient reported that there was no obvious pain in the buccal mucosa on the right side, no local numbness, normal bowel movements and urination, and the sleep had improved compared to before. The tongue was red, the tongue coating was yellow, and the pulse was soft and moist.

[0114] Examination: The buccal mucosa on the right side was congested, and white keratinized stripes measuring 8*4 mm could be seen. 2 The texture was light. For specific details, refer to Figure 2 the image of the patient after the second treatment in

[0115] III. Patient Three, female, 52 years old, initial diagnosis date: May 13, 2024.

[0116] Chief complaint: Pain in the buccal mucosa on both sides for more than half a year.

[0117] Present illness history: The patient had pain in the buccal mucosa without obvious cause half a year ago. The symptoms were particularly obvious during eating, and the symptoms would relieve after paying attention to diet, but the symptoms often recurred during that period. Recently, due to frequent staying up late, the above symptoms reappeared. After taking oral medications, the symptoms did not relieve. Now, for further treatment, the patient came to the doctor. The current symptoms are as follows: The patient reported discomfort and pain in the oral mucosa, which was obvious when eating spicy and stimulating foods, fatigue, accompanied by dry mouth, bitter taste, yellow urine, sticky stools, poor appetite, poor sleep quality, pale tongue, white and greasy tongue coating, tooth marks on the edge of the tongue, and a stringy and soft and moist pulse.

[0118] Examination: White keratinized stripes measuring 10*12 mm could be seen near the lower 6 teeth on the right buccal side, with a light texture and local mucosal swelling. For specific details, refer to 2 the image of the patient before treatment in Figure 3

[0119] Menstrual history: Menarche at the age of 14, regular menstrual periods, dark red color, normal amount.

[0120] Past medical history: In good health. ​

[0121] Traditional Chinese Medicine diagnosis: Oral erosion, syndrome of liver depression, spleen deficiency and dampness preponderance.

[0122] Western medicine diagnosis: Oral lichen planus.

[0123] Treatment principle: Soothe the liver and strengthen the spleen, clear heat and promote diuresis.

[0124] Chinese medicine for the first treatment: Xiaoxianyin, using Xiaoxianyin as described in Example 11, specifically as follows: Pogostemon cablin 10g, Dictamnus dasycarpus 6g, Paeonia lactiflora 10g, Coix lacryma-jobi 10g, Citrus reticulata 6g, Curcuma aromatica 10g, Spatholobus suberectus 6g, Coptis chinensis 2g, Talc 7g, Taraxacum mongolicum 12g, Glycyrrhiza uralensis 6g, 7 doses, taken with water, one dose per day, divided into two doses.

[0125] Follow-up visit time: May 20, 2024.

[0126] After the first treatment, the patient reported that the pain in the right oral mucosa was relieved, there was no local numbness, fatigue, the tongue was pale, the tongue coating was white and greasy, there were tooth marks on the edge of the tongue, and the pulse was string-like and soggy.

[0127] Examination: It was visible that there was a 6*8mm 2 white keratinized stripe near the lower 6 tooth in the right buccal area, with a light texture. For details, please refer to Figure 3 the image of the patient after the first treatment in

[0128] Chinese medicine for the second treatment: Xiaoxianyin, using Xiaoxianyin as described in Example 12, specifically as follows: Pogostemon cablin 10g, Dictamnus dasycarpus 6g, Paeonia lactiflora 10g, Coix lacryma-jobi 8g, Citrus reticulata 10g, Curcuma aromatica 10g, Spatholobus suberectus 10g, Coptis chinensis 2g, Talc 7g, Taraxacum mongolicum 10g, Glycyrrhiza uralensis 6g, 7 doses, taken with water, one dose per day, divided into two doses.

[0129] After the second treatment, the patient reported that there was no pain in the right oral mucosa, no other discomfort, the tongue was pale, the tongue coating was white and greasy, there were tooth marks on the edge of the tongue, and the pulse was soggy.

[0130] Examination: It was visible that there was a 4*5mm 2 white stripe in the right buccal area, with a light texture. For details, please refer to Figure 3 the image of the patient after the second treatment in

[0131] IV. Patient Four, female, 31 years old, initial diagnosis time: April 22, 2024.

[0132] Chief complaint: Pain in the left buccal mucosa for more than 3 months.

[0133] Current medical history: The patient had pain in the left buccal mucosa 5*10mm 2The ulcer surface of the patient complained of pain and discomfort in the left cheek mucosa, with obvious tingling, obvious pain when eating spicy and irritating food, accompanied by numbness and discomfort, red tongue, yellow and greasy tongue coating, tooth marks on the edge of the tongue, and rapid and stringy pulse.

[0134] Examination: 20*15mm can be seen on the left cheek 2 White keratinized streaks, medium texture, scattered distribution, redness and swelling of the affected mucosa, please refer to Figure 4 Image of the patient before treatment.

[0135] Menstrual history: Menarche at age 14, regular menstruation, dark red color, normal flow.

[0136] Past history: in good health.

[0137] TCM diagnosis: oral erosion, liver depression, spleen deficiency and dampness.

[0138] Western medicine diagnosis: oral lichen planus.

[0139] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0140] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 13, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 6g, Coix Seed 8g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 5g, Talcum 8g, Taraxacum 12g, Licorice 6g, 7 doses, taken with water, one dose a day, divided into two doses.

[0141] Follow-up date: April 29, 2024.

[0142] After the first treatment, the patient reported that the tightness of the left cheek mucosa was relieved, the tingling sensation was relieved during the day, and the symptoms were more obvious at night. He felt pain when eating spicy and irritating foods, and felt local numbness and discomfort. His tongue was red, with yellow fur, teeth marks on the sides of the tongue, and his pulse was stringy and slippery.

[0143] Examination: 20*13mm can be seen on the left cheek 2 White keratinized streaks, lighter in color, medium in texture, scattered, see Figure 4 Image of the patient after the first treatment.

[0144] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 14, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 6g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 2g, Talcum 8g, Taraxacum 12g, Licorice 5g, 7 doses, taken with water, one dose per day, divided into two doses.

[0145] After the second treatment, the patient reported that the stinging pain in the left buccal mucosa had significantly alleviated, the numbness and tightness had reduced, the tongue was dull red, the tongue coating was thin and yellow, and the pulse was stringy and thready;

[0146] Examination: On the left buccal area, there was a 16*10mm 2 white keratinized stripe, with a lighter color, medium texture, and scattered distribution. For details, please refer to Figure 4 the image of the patient after the second treatment.

[0147] After the second treatment, the third treatment was carried out, and the prescription used was the same as that for the second treatment;

[0148] After the third treatment, the patient reported that the stinging pain in the left buccal mucosa had significantly alleviated, there was no numbness and tightness, the tongue was light red, the tongue coating was thin, and the pulse was thready;

[0149] Examination: On the left buccal area, there was a 5*5mm 2 white keratinized stripe, with a lighter color and shallow texture. For details, please refer to Figure 4 the image of the patient after the third treatment.

[0150] V. Patient Five, 29 years old, initial diagnosis date: July 08, 2024.

[0151] Chief complaint: Erosion of the bilateral buccal mucosa for 3 years, aggravated for 1 month.

[0152] Current medical history: Three years ago, due to frequent smoking, drinking, and staying up late, the patient developed white keratinized stripes on the left lingual side, sized 5*8mm 2 , and the symptoms alleviated after self-medication. The symptoms worsened whenever the patient ate spicy food and recurred. One month ago, after eating spicy and stimulating food, the buccal mucosa pain and discomfort reappeared, mainly as stinging pain. The symptoms did not relieve after oral medication. Now, for further treatment, the patient came to the doctor. Symptoms: The patient reported pain and discomfort in the bilateral buccal mucosa, obvious pain during eating, accompanied by numbness of the tip of the tongue, bitter taste in the mouth in the morning, frequent chest tightness and discomfort, fear of heat, easy sweating, yellow urine, sticky stools, normal diet, good sleep, red tongue, yellow and greasy tongue coating, tooth marks on the edge of the tongue, and a soggy and rapid pulse.

[0153] Examination: On the left buccal mucosa, there was a 15*10mm 2 white keratinized stripe, with a soft and thick texture. On the right buccal area, there was an 8*10mm 2 white keratinized stripe, with a soft and thick texture. For details, please refer to Figure 5 the image of the patient before treatment.

[0154] Past medical history: Healthy.

[0155] Traditional Chinese medicine diagnosis: Oral erosion, syndrome of liver depression, spleen deficiency, and dampness preponderance.

[0156] Western medicine diagnosis: Oral lichen planus.

[0157] Treatment method: Soothe the liver and strengthen the spleen, clear away heat and remove dampness.

[0158] The first treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 14, specifically as follows: Patchouli 10g, Dictamni 8g, White Peony 6g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 6g, Millettia Reticulata 8g, Coptis chinensis 2g, Talcum 8g, Taraxacum 12g, Licorice 5g, 7 doses, taken with water, one dose per day, divided into two doses.

[0159] Follow-up date: July 15, 2024.

[0160] After the first treatment, the patient reported that the pain in the buccal mucosa on both sides was relieved, the numbness at the tip of the tongue was relieved, bowel movements were normal, the tongue was light red, the tongue coating was white and greasy, and the pulse was soft;

[0161] Examination: 10*6mm can be seen on the left cheek mucosa 2 White keratotic streaks, light in texture, 8*10mm visible on the right cheek 2 White keratinized stripes, light texture, please refer to Figure 5 Image of the patient after the first treatment.

[0162] The second treatment with Chinese medicine: Xiaozhen Decoction, using the Xiaozhen Decoction as described in Example 15, specifically as follows: Patchouli 8g, Dictamni 8g, White Peony 8g, Coix Seed 10g, Tangerine Peel 6g, Curcuma 8g, Millettia Spatholobi 8g, Coptis chinensis 2g, Talcum 8g, Taraxacum 12g, Licorice 8g, 7 doses, taken with water, one dose a day, divided into two doses.

[0163] After the second treatment, the patient reported no pain in the cheek mucosa on both sides, good sleep, normal bowel movements, pale red tongue, white fur, and a soft pulse.

[0164] Examination: 4*4mm can be seen on the left cheek mucosa 2 White keratotic streaks, light texture, light texture, please refer to Figure 5 Image of the patient after the second treatment.

[0165] It should be noted that the above-mentioned moss-eliminating drink can also correspond to the Chinese medicine composition described in Examples 1-9.

[0166] In summary, the present invention focuses on soothing the liver, invigorating the spleen and eliminating dampness, supplemented by regulating qi and activating blood circulation, so that liver depression can be relieved, qi can be regulated and blood vessels can be unblocked, spleen function can be strengthened, and water and dampness can be normally transported and distributed, thereby achieving the purpose of treating oral lichen planus of liver depression, spleen deficiency and dampness predominance type. The whole prescription has rigorous compatibility, and the monarch, minister, assistant and envoy perform their respective functions. The effects of soothing the liver, invigorating the spleen, eliminating dampness, activating blood circulation and clearing away heat complement each other. It not only targets the main pathogenesis of soothing the liver, invigorating the spleen and eliminating dampness, but also takes into account the pathological changes of blood stasis and stagnation of heat, reflecting the holistic concept and principle of syndrome differentiation and treatment in the treatment of oral lichen planus in traditional Chinese medicine.

[0167] The embodiments described above merely represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent for the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all fall within the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention shall be subject to the appended claims.

Claims

1. A Chinese medicine composition for treating oral lichen planus, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 8-10 parts of patchouli, 6-8 parts of dittany, 6-10 parts of white peony root, 8-10 parts of coix seed, 6-10 parts of tangerine peel, 6-10 parts of turmeric, 6-10 parts of millettia reticulata, 2-5 parts of coptis root, 7-10 parts of talc, 10-12 parts of dandelion, and 5-8 parts of liquorice.

2. The Chinese medicine composition for treating oral lichen planus according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of dried orange peel, 6 parts of curcuma, 8 parts of millettia, 2 parts of coptis, 10 parts of talc, 10 parts of dandelion, and 6 parts of liquorice.

3. Use of the traditional Chinese medicine composition for treating oral lichen planus according to claim 1 or 2 in the preparation of a medicament for treating oral lichen planus.

4. A decoction-free Chinese medicine granule for treating oral lichen planus, characterized in that: The Chinese medicine decoction-free granules are composed of the following single-ingredient Chinese medicine formula granules in parts by weight: 8-10 parts of patchouli, 6-8 parts of dittany, 6-10 parts of white peony root, 8-10 parts of coix seed, 6-10 parts of tangerine peel, 6-10 parts of turmeric, 6-10 parts of millettia reticulata, 2-5 parts of coptis root, 7-10 parts of talc, 10-12 parts of dandelion, and 5-8 parts of liquorice.

5. The Chinese medicine decoction-free granules for treating oral lichen planus according to claim 4, characterized in that: The Chinese medicine decoction-free granules are composed of the following single-ingredient Chinese medicine formula granules in parts by weight: 10 parts of patchouli, 8 parts of dittany, 10 parts of white peony root, 10 parts of coix seed, 6 parts of dried orange peel, 6 parts of curcuma, 8 parts of millettia, 2 parts of coptis, 10 parts of talc, 10 parts of dandelion, and 6 parts of liquorice.

6. Use of the decoction-free Chinese medicinal granules for treating oral lichen planus according to claim 4 or 5 in preparing a drug for treating oral lichen planus.

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