Composition formula for assisting in reducing blood sugar and preventing diabetes mellitus

Abstract

The invention discloses a formula of a composition capable of assisting in reducing blood sugar and preventing diabetes, and relates to the field of health food, the composition has the effects of reducing blood sugar and preventing diabetes, and the composition comprises the following composition components: 0.25 to 0.37% of bitter gourd peptide, 0.018 to 0.026% of corosolic acid, 0.39 to 0.48% of mulberry leaf extract, 0.083 to 0.095% of pseudo-ginseng extract, 0.115 to 0.132% of radix polygonati officinalis extract, and 0.00003 to 0.00005% of chromium-enriched yeast. By adopting the composition formula for assisting in reducing blood sugar and preventing diabetes, the formula composition has the effects of assisting in reducing the blood sugar level and treating. Meanwhile, the composition also has a synergistic effect on prevention of diabetes caused by hyperglycemia symptoms, the components of the composition are equal-part compositions formed by physical stirring and uniform mixing, and the increase of postprandial blood sugar level can be effectively inhibited, so that the effects of assisting beta cells of a body to secrete insulin and improving the blood sugar level are achieved. And insulin can promote the utilization of sugar by cells, the synthesis of hepatic glycogen and the improvement of the metabolism of sugar, so that the effect of reducing blood sugar is finally achieved. The raw materials of the composition can be purchased and obtained in the market, the raw materials are simple and easy to obtain, the production benefit is high, and the composition is suitable for being widely used.

Description

Technical Field

[0001] The invention relates to a formula of a combination for assisting in lowering blood sugar and preventing diabetes, and in particular to the field of health food for lowering blood sugar and preventing blood sugar from lowering blood sugar. Background Art

[0002] With the development of society, people's quality of life is constantly improving, and the food they eat is becoming more and more abundant. It is inevitable to eat foods high in salt, sugar, fat, and protein. At the same time, young people nowadays exercise less, which can easily lead to diabetes, a common disease. For diabetic patients, controlling the sugar in the body is a good way to inhibit diabetes. The treatment of diabetes is mainly to control blood sugar, which can prevent or delay complications and reduce mortality. In addition to the use of various hypoglycemic drugs and insulin, the early treatment of diabetes also involves diet therapy, that is, taking auxiliary treatment or diet and health-related intervention measures is also indispensable.

[0003] According to previous surveys, the current incidence of diabetes in my country is as high as 9.7%, which means that there are at least 100 million people in the country suffering from diabetes of varying degrees. Based on the current living standards, if it is not controlled or treated, the incidence rate will increase by 5% every year. Diabetes is currently a major disease that my country needs to face up to.

[0004] Therefore, the inventors have developed the composition of the present invention, which can effectively assist the increase of blood sugar levels after meals, thereby assisting the body's cells to secrete insulin, and insulin can promote the cell's utilization of sugar, liver glycogen synthesis and improve sugar metabolism, ultimately achieving the effect of lowering blood sugar. The composition of the present invention can be made into corresponding tablets, capsules, granules, pills or oral liquids according to the applicable population and portability. Summary of the invention

[0006] The purpose of the present invention is to provide a formula of a composition for assisting in lowering blood sugar and preventing diabetes. The composition for assisting in lowering blood sugar and preventing diabetes is mainly prepared by fully mixing and stirring momordica charantia peptide, corosolic acid, mulberry leaf extract, Panax notoginseng extract, Polygonatum odoratum extract, and chromium-rich yeast in a stirring pot. The multiple ingredients complement each other and effectively assist the human body in metabolizing blood sugar, thereby preventing the occurrence of diabetic symptoms.

[0007] Through long-term experiments, it was found that the hypoglycemic and anti-diabetic composition is mainly composed of bitter melon peptide (0.25-0.37), corosolic acid (0.018-0.026), mulberry leaf extract (0.39-0.48), Panax notoginseng extract (0.083-0.095), Polygonatum odoratum extract (0.115-0.132), chromium-enriched yeast (0.00003-0.00005) These compositions within this range of proportions can help the human body eliminate excess sugar that the body ingests daily. At the same time, mulberry leaf extract has pharmacological activities such as lowering blood sugar, lowering blood lipids, lowering blood pressure, antibacterial and antiviral, and anti-aging, and is often used in health foods.

[0008] The mulberry leaf extract has a hypoglycemic effect mainly through two pathways: first, the alkaloid DNJ inhibits the activity of disaccharide degrading enzymes, thereby inhibiting the absorption of disaccharides by the small intestine and reducing the rise in postprandial blood sugar levels; second, mulberry leaf alkaloids and mulberry leaf polysaccharides promote the secretion of insulin by β cells, and insulin can promote the cell's utilization of sugar, liver glycogen synthesis, and improve sugar metabolism, ultimately achieving the effect of lowering blood sugar.

[0009] The composition of the present invention and the raw materials used are not particularly specified and can all be obtained through conventional market purchasing channels: bitter melon peptide was purchased from Shandong Lusen Biotechnology Co., Ltd., corresponding to the brand name Lusen; corosolic acid was purchased from Hubei Guangao Biotechnology Co., Ltd., corresponding to the brand Guangao Bio; mulberry leaf extract was purchased from Chenzhou Mingrun Biological Products Co., Ltd., corresponding to the brand Yanghe Element; Panax notoginseng extract was purchased from Shanxi Yuning Biotechnology Co., Ltd., corresponding to the brand Yuning; Polygonatum odoratum extract was purchased from Shaanxi Wanyuan Biotechnology Co., Ltd., corresponding to the brand Wanyuan Lijian; chromium-rich yeast was purchased from Shenzhen Jinfuyuan Biotechnology Co., Ltd., corresponding to the brand Jinfuyuan. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 : The functional formulas of different hypoglycemic and anti-diabetic compositions have corresponding hypoglycemic effects after taking for 28 days, and all of them are effective.

[0011] Figure 2 : The experiments with different ingredients were conducted by comparing the mean values ​​± standard deviation before and after meals every week for 28 days. The blood sugar values ​​of the sample control group showed significant improvement compared with those of the model control group.

[0012] To achieve the above-mentioned purpose, the present invention provides a formula of a composition for assisting in lowering blood sugar and preventing diabetes, comprising the following ingredients: bitter melon peptide, corosolic acid, mulberry leaf extract, Panax notoginseng extract, Polygonatum odoratum extract, and chromium-rich yeast in corresponding proportions of (0.21-0.42): (0.015-0.035): (0.28-0.54): (0.075-0.098): (0.108-0.142): (0.00002-0.00006).

[0013] The embodiments of the bitter melon peptide and other compositions are as follows:

[0014] Furthermore, the proportions of Example 1 are as follows: bitter melon peptide (0.21), corosolic acid (0.015), mulberry leaf extract (0.28), Panax notoginseng extract (0.075), Polygonatum odoratum extract (0.108), and chromium-enriched yeast (0.00002), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring.

[0015] Furthermore, the proportions of Example 2 are grouped as follows: bitter melon peptide (0.24), corosolic acid (0.016), mulberry leaf extract (0.35), Panax notoginseng extract (0.079), Polygonatum odoratum extract (0.117), and chromium-enriched yeast (0.00003), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring.

[0016] Furthermore, the proportions of Example 3 are grouped as follows: bitter melon peptide (0.25), corosolic acid (0.0165), mulberry leaf extract (0.3), Panax notoginseng extract (0.08), Polygonatum odoratum extract (0.11), and chromium-enriched yeast (0.00004), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring.

[0017] Furthermore, the proportions of Example 4 are grouped as follows: bitter melon peptide (0.25), corosolic acid (0.018), mulberry leaf extract (0.39), Panax notoginseng extract (0.08), Polygonatum odoratum extract (0.11), and chromium-enriched yeast (0.00003), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring.

[0018] Furthermore, the proportions of Example 5 are grouped as follows: bitter melon peptide (0.3), corosolic acid (0.023), mulberry leaf extract (0.45), Panax notoginseng extract (0.09), Polygonatum odoratum extract (0.13), and chromium-enriched yeast (0.00004), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring.

[0019] Furthermore, the proportions of Example 6 are grouped as follows: bitter melon peptide (0.37), corosolic acid (0.026), mulberry leaf extract (0.48), Panax notoginseng extract (0.095), Polygonatum odoratum extract (0.132), and chromium-enriched yeast (0.00005), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring.

[0020] Furthermore, the proportions of Example 7 are grouped as follows: bitter melon peptide (0.42), corosolic acid (0.035), mulberry leaf extract (0.54), Panax notoginseng extract (0.098), Polygonatum odoratum extract (0.142), and chromium-enriched yeast (0.00006), wherein the chromium-enriched yeast composition has a molecular weight content of <5000 Daltons, and is prepared into equal amounts of granules by physical stirring. Specific implementation plan

[0021] In order to more intuitively reflect the feasibility of the composition of the implementation scheme, the example selected rats as experimental subjects. It is generally believed that the main objective of whether the experimental composition works on diabetes is to reduce the blood sugar level of the experimental object, so the inventor adopted an experimental example of hypoglycemic effect on rats. The experimental example is divided into seven groups, each group is divided into three small groups, each group is named: normal control group, model control group, sample treatment group, each group selected 3 rats weighing 152-175g, a total of 63 experimental rats.

[0022] The volume is equivalent to that of experimental rats. Before the experiment, the blood sugar level needs to be tested each time, and the blood sugar level is between 6.1<blood sugar level<6.5.

[0023] An appropriate amount of streptozotocin is injected into the experimental mice in the modeling control group and the sample treatment group, and an appropriate amount of high-sugar solution is added to their drinking water to increase their blood sugar levels. Streptozotocin selectively destroys the pancreatic β cells of the experimental mice, resulting in reduced insulin secretion and inducing diabetes.

[0024] After several days of feeding, the blood glucose levels of the fasting model control group and the sample treatment group were tested, and the blood glucose values ​​were 10-15mmo 1 / L, indicating that the simulated hyperglycemia model was successfully established.

[0025] After the modeling was successful, the experimental mice were divided into seven groups, with 3 mice in each group of the model control group and the sample treatment group. The total duration of the experiment was 28 days. Each experimental mouse had free food and water on a daily basis, and the same amount of food was fed each time. Blood was taken from the tail of each group of experimental mice every weekend to detect changes in blood sugar levels. Among them, the experimental mice in the normal control group did not receive other treatments and had free food and water. The changes in blood sugar levels before and after meals were counted every weekend. The model control group had free food and water on a daily basis, and a high sugar solution was added to the drinking water to simulate the corresponding blood sugar value of diabetes. At the same time, the changes in blood sugar levels before and after meals were counted. The sample treatment group had free food and water on a daily basis, and the experimental example composition solution was added to the drinking water at the same time as the high sugar solution was added to the drinking water, and the changes in blood sugar levels before and after meals were counted every week.

[0026] Example 1

[0027] The proportions of Example 1 are as follows: bitter melon peptide (0.21), corosolic acid (0.015), mulberry leaf extract (0.28), Panax notoginseng extract (0.075), Polygonatum odoratum extract (0.108), and chromium-enriched yeast (0.00002). The chromium-enriched yeast composition is prepared into equal amounts of granules by physical stirring. The granules of the composition of Example 1 are fully dissolved in water, and a solution of the granules of the composition with a maximum safety value of 1000 μg / mL is taken and added to the drinking water of the experimental mice in the sample treatment group described in 5 every day to detect the changes in the blood glucose levels of the experimental mice in the sample treatment group.

[0028] Example 2.

[0029] The composition of Example 2 is divided into groups: bitter melon peptide (0.24), corosolic acid (0.016), mulberry leaf extract (0.35), Panax notoginseng extract (0.079), Polygonatum odoratum extract (0.117), and chromium-enriched yeast (0.00003). Equal amounts of granules are prepared by physical stirring. The composition granules of Example 2 are fully dissolved in water. A solution of the composition granules with a maximum safety value of 1000 μg / mL is taken and added into the drinking water of the experimental mice in the sample treatment group described in 5 every day to detect the changes in blood glucose levels of the experimental mice in the sample treatment group.

[0030] Example 3

[0031] The composition of Example 3 is divided into groups: bitter melon peptide (0.25), corosolic acid (0.0165), mulberry leaf extract (0.3), Panax notoginseng extract (0.08), Polygonatum odoratum extract (0.11), and chromium-enriched yeast (0.00004). Equal amounts of granules are prepared by physical stirring. The composition granules of Example 3 are fully dissolved in water. A solution of the composition granules with a maximum safety value of 1000 μg / mL is taken and added into the drinking water of the experimental mice in the sample treatment group described in 5 every day to detect the changes in blood glucose levels of the experimental mice in the sample treatment group.

[0032] Example 4

[0033] The composition of Example 4 is divided into groups: bitter melon peptide (0.25), corosolic acid (0.018), mulberry leaf extract (0.39), Panax notoginseng extract (0.08), Polygonatum odoratum extract (0.11), and chromium-enriched yeast (0.00003). Equal amounts of granules are prepared by physical stirring. The composition granules of Example 4 are fully dissolved in water. A solution of the composition granules with a maximum safety value of 1000 μg / mL is taken and added into the drinking water of the experimental mice in the sample treatment group described in 5 every day to detect the changes in blood glucose levels of the experimental mice in the sample treatment group.

[0034] Example 5

[0035] The proportions of Example 5 are grouped as follows: bitter melon peptide (0.3), corosolic acid (0.023), mulberry leaf extract (0.45), Panax notoginseng extract (0.09), Polygonatum odoratum extract (0.13), and chromium-enriched yeast (0.00004). Equal amounts of granules are prepared by physical stirring. The composition granules of Example 5 are fully dissolved in water, and a solution of the composition granules with a maximum safety value of 1000 μg / mL is taken and added to the drinking water of the experimental mice in the sample treatment group described in Example 5 every day to detect the changes in blood glucose levels of the experimental mice in the sample treatment group.

[0036] Example 6

[0037] The Example 6 is divided into groups of bitter melon peptide (0.37), corosolic acid (0.026), mulberry leaf extract (0.48), Panax notoginseng extract (0.095), Polygonatum odoratum extract (0.132), and chromium-enriched yeast (0.00005). Equal amounts of granules are prepared by physical stirring. The composition granules of Example 6 are fully dissolved in water. A solution of the composition granules with a maximum safety value of 1000 μg / mL is taken and added to the drinking water of the experimental mice in the sample treatment group described in 5 every day to detect the changes in blood glucose levels of the experimental mice in the sample treatment group.

[0038] Example 7

[0039] The composition of Example 7 is divided into groups: bitter melon peptide (0.42), corosolic acid (0.035), mulberry leaf extract (0.54), Panax notoginseng extract (0.098), Polygonatum odoratum extract (0.142), and chromium-enriched yeast (0.00006). Equal amounts of granules are prepared by physical stirring. The composition granules of Example 7 are fully dissolved in water. A solution of the composition granules with a maximum safety value of 1000 μg / mL is taken and added to the drinking water of the experimental mice in the sample treatment group described in 5 every day to detect the changes in blood glucose levels of the experimental mice in the sample treatment group.

[0040] In the above experiments, a composition particle solution with a concentration of 1000 μg / mL, which is the maximum safe value, was used.

[0041] The data analysis was mainly performed using SPSS26 software, and GraphPad Prism8 was used for drawing. The data statistics were expressed as mean ± standard deviation. The experimental results were tested for normal distribution using SPSS software. If the data conformed to the normal distribution, the T parameter test or analysis of variance (ANOVA) was used for significance. If it did not conform to the normal distribution, a non-parametric test was used.

[0042] The corresponding numerical comparison results produced by the experiment show that the average blood glucose value of the sample treatment group is significantly reduced or unchanged when compared with the model control group, indicating that the test composition in the sample treatment group has obvious blood glucose lowering function.

[0043] Through the above Figure 2 The blood sugar value test shows that the blood sugar lowering and diabetes prevention functional composition disclosed in the present invention has good results in Examples 1-7 and Examples 4-6 in the blood sugar value test results. Figure 2 In the implemented experimental cases, the corresponding composition ratio of the composition disclosed in the present invention for the auxiliary blood sugar lowering and anti-diabetes functional composition, including bitter melon peptide (0.25-0.37), corosolic acid (0.018-0.026), mulberry leaf extract (0.39-0.48), Panax notoginseng extract (0.083-0.095), Polygonatum odoratum extract (0.115-0.132), and chromium-rich yeast (0.00003-0.00005), has a relatively obvious auxiliary blood sugar lowering effect.

[0044] Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified in proportion or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A formula for a composition for assisting in lowering blood sugar and preventing diabetes, wherein the main components of the composition for assisting in lowering blood sugar and preventing diabetes are bitter melon peptide, corosolic acid, mulberry leaf extract, Panax notoginseng extract, Polygonatum odoratum extract, and chromium-rich yeast, which cooperate with each other and are evenly mixed by physical stirring to form a composition in relative proportions.

2. In the formula of the auxiliary blood sugar lowering and diabetes prevention composition: the corresponding proportions of bitter melon peptide, corosolic acid, mulberry leaf extract, Panax notoginseng extract, Polygonatum odoratum extract, and chromium-rich yeast are (0.25-0.37): (0.018-0.026): (0.39-0.48): (0.083-0.095): (0.115-0.132): (0.00003-0.00005); the combination ratio is evenly mixed by sufficient physical stirring to obtain a composition with an optimal ratio.

3. The composition for assisting in lowering blood sugar and preventing diabetes according to claim 1, wherein Chromium-rich yeast, the molecular weight of this ingredient is <5000Da.

4. The composition for assisting in lowering blood sugar and preventing diabetes according to claim 1, characterized in that The synergistic combination of any one or more of the compositions of items 1-6 can achieve the purpose of assisting in lowering blood sugar and having a good preventive effect on diabetes.

5. The composition for assisting in lowering blood sugar and preventing diabetes according to claim 1, characterized in that: The hypoglycemic composition accounts for 90%-95% of the total ingredients.

6. The auxiliary blood sugar lowering and diabetes prevention composition according to claim 1, characterized in that: The formula composition is easily soluble in water and easily absorbed and transformed by the human body.

7. According to the formula of the auxiliary blood sugar lowering and diabetes prevention composition of claim, a certain proportion of the composition is evenly mixed and stirred to form a granular composition containing a corresponding amount, and the composition can also be made into corresponding tablets, capsules, granules, pills or oral liquids.

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