L-5-Methyltetrahydrofolate calcium separation device and method

Abstract

The present invention relates to the field of separation, and in particular to an L-5-methyltetrahydrofolate calcium separation device and method. The device comprises a reactor with a hollow interior, wherein a processing chamber and a separation chamber are connected to the reactor, the processing chamber and the separation chamber are connected via a connecting pipe, and a separator for filtering and separating a mixed liquid is provided in the separation chamber. The device controls the intermittent rotation of a driving shaft, thereby enabling replacement of a filter disc at any filter cartridge without shutting down the entire device, thereby improving the continuous operation time and production efficiency of the device. Furthermore, the device achieves synchronous rotation of the driving shaft, the transmission shaft, and the driving shaft through the cooperation of a transmission shaft, a bevel gear, and a synchronous belt, thereby ensuring coordinated stirring, filtering, and discharge, and improving overall operating efficiency.

Description

Technical Field

[0001] The present invention relates to the field of separation, and in particular to a device and method for separating L-5-methyltetrahydrofolate calcium. Background Art

[0002] L-5-Methyltetrahydrofolate calcium is an important folic acid derivative widely used in medicine, food additives, and nutritional supplements. Due to its high bioavailability and stability, market demand is increasing. To improve the purity and yield of L-5-methyltetrahydrofolate calcium, the development of efficient separation equipment is of great significance. Existing processes for the separation and extraction of L-5-methyltetrahydrofolate calcium typically include key steps such as pretreatment of plant raw materials, activation synthesis, and enzymatic separation, with the separation and purification process being particularly complex. Traditional separation methods rely on physical or chemical means, which are prone to problems such as long process flows, high energy consumption, and low processing efficiency.

[0003] With the development of science and technology, technicians in related fields have also made extensive optimizations in the technical means for separating and extracting L-5-methyltetrahydrofolate calcium. For more accurate comparison, Chinese Patent Publication No. CN114130097A discloses a purification method and apparatus for preparing L-5-methyltetrahydrofolate calcium, including a chassis, a solution tank, a filtration assembly, a filter paper switching device, and a liquid receiving tank. During use, the telescopic device and the filter paper switching device cooperate with each other to achieve automatic filter paper replacement, eliminating the need for manual replacement by operators. In addition, when the switched filter paper roll is wound on the roller, a scraper plate directly scrapes off the crystal material, thereby achieving an automatic material unloading process. The entire filtration device has a novel structural design and a high degree of automation, and can achieve efficient industrial purification and processing of L-5-methyltetrahydrofolate calcium, with excellent actual use results.

[0004] However, the above technical means for separating and purifying L-5-methyltetrahydrofolate calcium still have the following shortcomings in actual use:

[0005] The device uses a telescopic device to lift the solution tank up and down and place the filter paper on the filter paper, which is then pulled by a winding motor. After each filtration of a certain amount is completed, the solution tank is lifted upward to separate the pressure ring from the support tray. The filter paper roll is then extended from the strip opening by the winding motor. At this time, the circular filter disc at the next station above the filter paper roll is exactly between the pressure ring and the support tray. When the filtration operation is performed again, the telescopic device is directly controlled to press the solution tank down, thereby achieving automatic replacement of the filter paper. However, when the filter paper in the device needs to be replaced, the solution tank must first be driven upward by the telescopic device to separate the pressure ring from the support tray before the filter paper can be replaced. In other words, each time the filter paper needs to be replaced, the solution tank must be driven upward as a whole, causing the separation and purification process of L-5-methyltetrahydrofolate to be suspended for a period of time until the filter paper is replaced. This greatly reduces the efficiency of industrial separation and purification of L-5-methyltetrahydrofolate.

[0006] Therefore, based on the above-stated viewpoint, there is still room for improvement in the existing technical means for separating and purifying L-5-methyltetrahydrofolate calcium. Summary of the Invention

[0007] In order to solve the above problems, the present invention provides an L-5-methyltetrahydrofolate calcium separation device, which includes a hollow reactor, a processing chamber and a separation chamber connected to the reactor, and the processing chamber and the separation chamber are connected by a connecting pipe. The separation chamber is provided with a separator for filtering and separating the mixed liquid.

[0008] Preferably, the separator includes an active rotating shaft limitedly passed through the separation bin, a separation cylinder is coaxially connected between the active rotating shaft and the connecting pipe, the separation cylinder is connected to the connecting pipe, and a plurality of filter cylinders are evenly connected circumferentially on the separation cylinder.

[0009] Preferably, a driving shaft is provided through the middle of the processing chamber, and the driving shaft is connected to a stirring frame limitedly located in the processing chamber.

[0010] Preferably, two ends of the same filter cylinder are symmetrically connected with driven rotating rods, and driven gears are sleeved on the driven rotating rods. All driven gears on the same side of the separation cylinder are engaged with the regulating gear limitedly located in the separation chamber.

[0011] Preferably, the filter cartridge is limit-connected to the separation cartridge, and an opening is provided on the filter cartridge to connect with the separation cartridge, and a filter plate is limit-connected on one side of the filter cartridge away from the opening to filter and separate the mixed liquid entering the separation cartridge and the filter cartridge.

[0012] Preferably, a discharge channel is formed on the lower side of the separation bin, a guide plate is rotatably connected to the discharge channel, and the guide plate and the separation cylinder are connected by a torsion spring.

[0013] Preferably, the filter disc is in an arc-shaped structure and fits on the filter cartridge. An extension block embedded in the filter cartridge is symmetrically connected to the filter disc. A clamping ring for limiting the extension block is symmetrically connected between the separation cartridge and the filter cartridge.

[0014] Preferably, a snap-fit ​​groove is formed on the filter cartridge at a position corresponding to the extension block, and the extension block and the filter cartridge are commonly connected to a return spring limitedly located in the snap-fit ​​groove.

[0015] Preferably, a liquid outlet channel is formed at the lower side of the separation chamber, and a collection chamber is provided in the reactor at a position corresponding to the liquid outlet channel so as to collect and process the filtered mixed liquid.

[0016] In addition, the present invention also provides a method for separating L-5-methyltetrahydrofolate calcium, which uses a specific separation device for purification and separation. The separation method comprises the following steps:

[0017] S1. Take an appropriate amount of crude L-5-methyltetrahydrofolate calcium material, put it into deionized water, heat and stir until it is evenly mixed with the deionized water, and then perform ultrasonic treatment.

[0018] S2. Heating the mixed solution after ultrasonic treatment to reflux.

[0019] S3. The mixed solution after heating and refluxing is placed in a reactor for filtration and separation, and the separated crystals are dried to obtain refined L-5-methyltetrahydrofolate calcium.

[0020] In summary, this application includes at least one of the following beneficial technical effects:

[0021] 1. The present invention controls the intermittent rotation of the active shaft, and can replace the filter disc at any filter cartridge without shutting down the entire equipment, thereby improving the continuous operation time and production efficiency of the equipment. The cooperation of the transmission shaft, bevel gear and synchronous belt realizes the synchronous rotation of the driving shaft, transmission shaft and active shaft, ensuring the coordinated progress of stirring, filtration and discharge, and improving the overall operating efficiency.

[0022] 2. The present invention drives the separation cylinder and the filter cylinder to rotate intermittently through the active rotating shaft, thereby avoiding the long-term accumulation of crystals in the filter cylinder, thereby effectively preventing the filter holes from being blocked. Then, the filter cylinder is rotated and adjusted relative to the separation cylinder by cooperating with the driven gear, further preventing the accumulation of crystals. The filtered crystals in the filter cylinder are discharged during the rotation of the filter cylinder through the cooperation between the guide plate and the separation cylinder, so as to be dried subsequently.

[0023] 3. The present invention can effectively retain crystals through the evenly distributed filter holes on the filter cartridge, while allowing the aqueous solution to pass through, ensuring separation efficiency. The mutual cooperation between the clamping ring, the return spring and the extension block makes the filter disc fit tightly on the filter cartridge, further improving the filtration accuracy and facilitating the replacement of the filter disc. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The present invention will be further described below with reference to the accompanying drawings and examples.

[0025] Figure 1 It is a schematic structural diagram of the separation device of the present invention.

[0026] Figure 2 It is a schematic diagram of the cross-sectional structure of the reactor of the present invention.

[0027] Figure 3 It is a structural schematic diagram of the separator of the present invention.

[0028] Figure 4 It is a schematic structural diagram of the discharge channel of the present invention.

[0029] Figure 5 It is a schematic structural diagram of the filter disc of the present invention.

[0030] Figure 6 It is a structural schematic diagram of the adjusting gear of the present invention.

[0031] Figure 7 It is a structural schematic diagram of the guide plate of the present invention.

[0032] Figure 8 It is a structural schematic diagram of the filter cartridge of the present invention.

[0033] Figure 9 This invention Figure 8 Magnified image in .

[0034] Figure 10 It is a flow chart of the steps of the method of the present invention.

[0035] In the figure, 10, reactor; 11, processing chamber; 12, separation chamber; 13, connecting pipe; 14, separator; 140, driving shaft; 141, separation cylinder; 142, filter cylinder; 143, driving shaft; 144, stirring frame; 15, driven rotating rod; 150, driven gear; 151, adjusting gear; 16, opening; 160, filter plate; 161, discharge channel; 162, guide plate; 163, transmission shaft; 164, bevel gear; 17, extension block; 170, clamping ring; 171, engaging groove; 172, return spring; 18, liquid outlet channel; 19, collecting chamber. DETAILED DESCRIPTION

[0036] The following is combined with Figures 1 to 10 The embodiments of the present invention are described in detail.

[0037] The embodiments of the present application disclose an L-5-methyltetrahydrofolate calcium separation device and method. It is explained that the present application is mainly used in the process of separating and purifying L-5-methyltetrahydrofolate calcium, and technically achieves the effect of separating and extracting L-5-methyltetrahydrofolate calcium from a mixed solution containing L-5-methyltetrahydrofolate calcium. In particular, during the separation process, the mutual cooperation between the rotating separation cylinder and the filter cylinder effectively avoids the problem of excessive accumulation of L-5-methyltetrahydrofolate calcium after filtration and separation in the filter cylinder and the separation cylinder, resulting in clogging of the filter holes thereon. Furthermore, the present application also realizes intermittent rotation of the separation cylinder by the mutual cooperation between the bevel gears between the driving shaft and the transmission shaft, and dynamically adjusts the position of the filter cylinder on the separation cylinder, so as to ensure the continuous extraction and separation of L-5-methyltetrahydrofolate while replacing the filter disc on the filter cylinder.

[0038] Example 1, refer to Figure 1 As shown, a L-5-methyltetrahydrofolate calcium separation device includes a hollow reactor 10, a processing chamber 11 and a separation chamber 12 connected to the reactor 10, the processing chamber 11 and the separation chamber 12 being connected via a connecting pipe 13, and a separator 14 for filtering and separating the mixed liquid is provided in the separation chamber 12. During use, the heated mixed liquid is introduced into the processing chamber 11 and then introduced into the separation chamber 12 via the connecting pipe 13. The mixed liquid entering the separation chamber 12 is then filtered and separated by the separator 14 to separate the L-5-methyltetrahydrofolate calcium crystals precipitated in the mixed liquid. Finally, the separated crystals are dried to obtain refined L-5-methyltetrahydrofolate calcium.

[0039] It should be noted that crude L-5-methyltetrahydrofolate calcium solution is prepared by crude L-5-methyltetrahydrofolate and deionized water under certain temperature conditions. The impurities separated by this application are mostly unreacted or undissolved L-5-methyltetrahydrofolate, calcified salts (usually calcium chloride), and related reaction by-products in the crude L-5-methyltetrahydrofolate calcium solution.

[0040] Reference Figure 3As shown, the separator 14 includes a driving shaft 140 that is limitedly inserted into the separation chamber 12. A separation barrel 141 is coaxially connected between the driving shaft 140 and the connecting pipe 13. The separation barrel 141 is connected to the connecting pipe 13. A plurality of filter barrels 142 are evenly connected to the separation barrel 141 in a circumferential direction. During use, a mixed liquid is introduced into the separation barrel 141 through the connecting pipe 13. After the mixed liquid flows into the filter barrel 142 connected to the separation barrel 141, it is separated therein, so that the crystals precipitated in the mixed liquid remain in the filter barrel 142, and the remaining aqueous solution is discharged outward through the filter barrel 142, thereby achieving the effect of separating and extracting the precipitated crystals in the mixed liquid.

[0041] Reference Figure 3 As shown, to increase the rate of crystallization of the mixed solution within the processing chamber 11, a drive shaft 143 is provided in the upper middle portion of the processing chamber 11. Drive shaft 143 is connected to a stirring frame 144 positioned within the processing chamber 11. During operation, conventional motor technology is used to drive drive shaft 143 and stirring frame 144 to rotate, thereby shifting the mixed solution within the processing chamber 11, increasing the fluidity of the mixed solution and facilitating the crystallization of L-5-methyltetrahydrofolate calcium from the mixed solution.

[0042] As an optional embodiment, a heating jacket can be mounted on the outside of the processing chamber 11. By cooperating with the heating jacket and the stirring frame 144, the temperature during the preparation process can be effectively controlled to increase the efficiency of L-5-methyltetrahydrofolate calcium crystallization.

[0043] Reference Figure 3As shown, the two ends of the same filter cylinder 142 are symmetrically connected to the driven rotating rod 15, and the driven rotating rod 15 is provided with a driven gear 150. All the driven gears 150 on the same side of the separation cylinder 141 are meshed with the adjustment gear 151 limitedly located in the separation chamber 12. When in use, by driving the active rotating shaft 140 to rotate, the active rotating shaft 140 rotates and drives the separation cylinder 141 and the several filter cylinders 142 on the separation cylinder 141 to rotate synchronously. The rotation of the filter cylinder 142 drives the connected driven rotating rod 15 and the driven gear 150 to rotate, so that a relative rotation effect is formed between the driven gear 150 and the adjustment gear 151. At this time, the adjustment gear 151 limits the meshing driven gear 150, drives the driven gear 150, the driven rotating rod 15 and the connected filter cylinder 142 to rotate, so that the filter cylinder 142 A relative rotation effect is formed between the separation cylinder 141, that is, all the filter cylinders 142 rotate synchronously with the separation cylinder 141, and are also driven by their respective connected driven rotating rods 15 and driven gears 150 to rotate and adjust with the driven rotating rod 15 as the axis. The rotating filter cylinders 142 and the separation cylinder 141 prevent any filter cylinder 142 on the separation cylinder 141 from staying in the same position for a long time, which may easily cause excessive accumulation of precipitated crystals on the upper side to block the filter holes on the filter cylinder 142, and then affect the subsequent filtering and separation effect of the mixed liquid.

[0044] Reference Figure 3 As shown, the filter cartridge 142 is rotatably connected to the separation cartridge 141, and an opening 16 is provided on the filter cartridge 142 to be connected to the separation cartridge 141. A filter disc 160 is limitedly connected to one side of the filter cartridge 142 away from the opening 16. The filter disc 160 is evenly provided with a plurality of filter holes so as to filter and separate the mixed liquid entering the separation cartridge 141 and the filter cartridge 142. During use, after the mixed liquid introduced into the separation cartridge 141 flows to the filter cartridge 142, the opening 16 on any one of the filter cartridges 142 is driven to be connected to the separation cartridge 141 accordingly, so that the L-5-methyltetrahydrofolate calcium crystals precipitated in the mixed liquid are retained in the filter cartridge 142, and then the separation cartridge 141 and all the filter cartridges 142 are driven to rotate synchronously to avoid the problem that too many L-5-methyltetrahydrofolate calcium crystals filtered out of the same filter cartridge 142 accumulate on each other, resulting in clogging of the filter holes on the filter disc 160 and affecting the subsequent filtration and separation efficiency.

[0045] Further, refer to Figure 3As shown, in order to facilitate the discharge of L-5-methyltetrahydrofolate calcium crystals remaining in the filter cartridge 142 after filtration for subsequent drying treatment, a discharge channel 161 is formed on the lower side of the separation chamber 12, and a guide plate 162 is rotatably connected to the discharge channel 161. The guide plate 162 and the separation cartridge 141 are connected by a torsion spring. A collection box for collecting the discharged L-5-methyltetrahydrofolate calcium crystals is also provided on the reactor 10. In the initial state, the guide plate 162 is driven by the torsion spring to be inclined and pressed against the outer side of the separation cylinder 141. After the separation cylinder 141 and the plurality of filter cylinders 142 are driven to rotate, the rotating filter cylinder 142 will push the guide plate 162 to deflect downward, causing the torsion spring to be further deformed. In this process, the end of the guide plate 162 close to the filter cylinder 142 will be pressed against the filter disc 160, and with the rotation and displacement of the filter cylinder 142 and the filter disc 160, the outer side of the filter disc 160 is scraped to prevent the precipitated small particles from adhering to the filter disc 160 and affecting the subsequent filtering effect. After passing over the guide plate 162, the guide plate 162 is again pressed against the separation cylinder 141 under the drive of the deformed torsion spring. At this time, one of the filter cylinders 142 and the filter plate 160 that has rotated over the guide plate 162 is driven by the connected driven rotating rod 15 and the driven gear 150, and rotates with the driven rotating rod 15 as the axis, and rotates the opening 16 on the filter cylinder 142 to face the discharge channel 161, so that the crystals filtered and separated in the filter cylinder 142 fall to the guide plate 162, and then are discharged outward along the guide plate 162, completing the collection of the L-5-methyltetrahydrofolate calcium crystals for subsequent drying treatment.

[0046] Furthermore, in order to drive the filter cartridge 142 to rotate at the discharge channel 161 to discharge the filtered crystals while rotating with the separation cartridge 141, the adjustment gear 151 is set as an incomplete gear, so that the driven rotating rod 15 and the driven gear 150 connected to the filter cartridge 142 only rotate at the discharge channel 161, and then reset to connect with the separation cartridge 141, so as to avoid leakage of the filtered crystals in the filter cartridge 142.

[0047] As an optional embodiment, a transmission shaft 163 is further connected to the reactor 10 and is arranged parallel to the active rotating shaft 140. The transmission shaft 163 and the driving rotating shaft 143 are connected by a bevel gear 164, and the transmission shaft 163 and the active rotating shaft 140 are connected by a synchronous belt transmission to achieve a synchronous rotation effect between the driving rotating shaft 143, the transmission shaft 163 and the active rotating shaft 140.

[0048] Furthermore, any one of the two bevel gears 164 between the transmission shaft 163 and the driving shaft 143 is set as an incomplete bevel gear 164, so as to achieve the effect of continuously driving the driving shaft 143 to rotate and intermittently driving the transmission shaft 163 and the active shaft 140 to rotate. The driving shaft 143 drives the connected stirring frame 144 to rotate continuously, so as to achieve the effect of promoting the precipitation efficiency of the mixed liquid in the processing chamber 11. By intermittently driving the active shaft 140 to rotate, the active shaft 140 rotates to drive the separation cylinder 141 and several filter cylinders 142 to rotate intermittently, so as to achieve the effect of increasing the filtration efficiency of the filter cylinder 142.

[0049] Reference Figure 3 As shown, the filter disc 160 is an arc-shaped structure that fits on the filter cartridge 142. The filter disc 160 is symmetrically connected to an extension block 17 that fits on the filter cartridge 142. A clamping ring 170 is symmetrically connected between the separation cartridge 141 and the filter cartridge 142 to limit the position of the extension block 17. During use, when the separation cartridge 141 and all the filter cartridges 142 are driven to rotate, the extension blocks 17 connected to both ends of the filter disc 160 on the filter cartridge 142 are limited and compressed by the clamping ring 170, so that the extension block 17 and the filter disc 160 fit tightly against the filter cartridge 142, thereby separating and filtering out the crystals precipitated in the mixed liquid.

[0050] Further, refer to Figure 3 As shown, in order to facilitate the removal and replacement of the filter disc 160 limited on the filter cartridge 142, the clamping ring 170 is an arc shape with a notch, and a snap-fit ​​groove 171 is formed on the filter cartridge 142 corresponding to the extension block 17. The extension block 17 and the filter cartridge 142 are commonly connected with a return spring 172 limited in the snap-fit ​​groove 171. It should be noted that one end of the return spring 172 is limitedly connected in the snap-fit ​​groove 171, and the other end is fitted and held on the extension block 17 so as to disengage from the extension block 17. During normal use, the return spring 172 is limitedly compressed in the snap-fit ​​groove 171 and has a tendency to always protrude outward from the connected snap-fit ​​groove 171 so as to drive the extension block 17 and the filter disc 160 to separate from the connected filter cartridge 142. During use, when the separation cylinder 141, the filter cylinder 142, the filter disc 160 and the extension block 17 are driven to rotate, the extension block 17 and the filter disc 160 are pressed and limited to the connected filter cylinder 142 through the clamping ring 170. When any one of the filter cylinders 142 and the connected filter disc 160 and the extension block 17 rotates to the notch section at the clamping ring 170, the compressed reset spring 172 drives the connected extension block 17 and the filter disc 160 to slide away from the separation cylinder 141, thereby facilitating the subsequent replacement of the filter disc 160.

[0051] At the same time, since the separation cylinder 141 and all the filter cylinders 142 rotate back and forth intermittently, the filter disc 160 at any one of the filter cylinders 142 can be replaced by controlling the intermittent rotation of the active rotating shaft 140 without shutting down the entire equipment, thereby effectively improving the efficiency of separating L-5-methyltetrahydrofolate calcium.

[0052] Of course, when there is no need to remove the filter plate 160 for replacement, a limiting slide concentric with the clamping ring 170 can be detachably connected to the notch section of the clamping ring 170 to avoid accidental separation of the filter plate 160 and the filter cartridge 142 during normal use, thereby affecting subsequent filtration and separation.

[0053] Reference Figure 3 As shown, a liquid outlet channel 18 is formed at the lower side of the separation chamber 12 , and a collection chamber 19 is provided in the reactor 10 corresponding to the liquid outlet channel 18 so as to collect and process the filtered mixed liquid.

[0054] When the above-mentioned separation device is used to separate L-5-methyltetrahydrofolate calcium, the separation method includes the following steps:

[0055] S1. Take an appropriate amount of crude L-5-methyltetrahydrofolate calcium material, put it into deionized water, heat and stir until it is evenly mixed with the deionized water, and then ultrasonically treat it for 15 minutes.

[0056] S2. Heating the mixed solution after ultrasonic treatment to at least 50° C. (preferably between 50° C. and 60° C.) for reflux.

[0057] S3. The mixed solution after heating and refluxing is placed in the reactor 10 for filtration and separation, and the separated crystals are dried at a temperature of 60° C. to obtain refined L-5-methyltetrahydrofolate calcium.

[0058] The embodiments of this specific implementation method are all preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Therefore, any equivalent changes made based on the structure, shape, and principle of the present invention should be included in the scope of protection of the present invention.

Claims

1. A L-5-methyltetrahydrofolate calcium separation device, characterized in that: The reactor (10) comprises a hollow reactor (10), wherein a processing chamber (11) and a separation chamber (12) are connected to the reactor (10), the processing chamber (11) and the separation chamber (12) are connected via a connecting pipe (13), and a separator (14) for filtering and separating a mixed liquid is provided in the separation chamber (12); The separator (14) includes a driving shaft (140) that is limitedly inserted into the separation chamber (12); a separation cylinder (141) is coaxially connected between the driving shaft (140) and the connecting pipe (13); the separation cylinder (141) is connected to the connecting pipe (13); and a plurality of filter cylinders (142) are evenly connected to the separation cylinder (141) in a circumferential direction. A driving shaft (143) is provided in the middle of the processing chamber (11), and the driving shaft (143) is connected to a stirring frame (144) which is located within the processing chamber (11); Both ends of the filter cylinder (142) are symmetrically connected to driven rotating rods (15), and driven gears (150) are sleeved on the driven rotating rods (15). All driven gears (150) on the same side of the separation cylinder (141) are engaged with an adjustment gear (151) limitedly located in the separation chamber (12). The adjusting gear (151) is set as an incomplete gear; The filter cartridge (142) is positionally connected to the separation cartridge (141), and an opening (16) is provided on the filter cartridge (142) and is connected to the separation cartridge (141). A filter sheet (160) is positionally connected to a side of the filter cartridge (142) away from the opening (16) so as to filter and separate the mixed liquid entering the separation cartridge (141) and the filter cartridge (142); A transmission shaft (163) is also connected to the reactor (10) and is arranged parallel to the driving shaft (140). The transmission shaft (163) and the driving shaft (143) are connected to each other via a bevel gear (164). The transmission shaft (163) and the driving shaft (140) are connected to each other via a synchronous belt. Any one of the two bevel gears (164) between the transmission shaft (163) and the driving shaft (143) is configured as an incomplete bevel gear (164).

2. A L-5-methyltetrahydrofolate calcium separation device according to claim 1, characterized in that: The filter disc (160) is in an arc-shaped structure and fits on the filter barrel (142). An extension block (17) embedded in the filter barrel (142) is symmetrically connected to the filter disc (160). A clamping ring (170) for limiting the extension block (17) is symmetrically connected between the separation barrel (141) and the filter barrel (142).

3. A L-5-methyltetrahydrofolate calcium separation device according to claim 2, characterized in that: A snap-fit ​​groove (171) is formed on the filter cartridge (142) at a position corresponding to the extension block (17), and a return spring (172) located within the snap-fit ​​groove (171) is connected between the extension block (17) and the filter cartridge (142).

4. A L-5-methyltetrahydrofolate calcium separation device according to claim 1, characterized in that: A liquid outlet channel (18) is formed on the lower side of the separation chamber (12), and a collection chamber (19) is provided in the reactor (10) at a position corresponding to the liquid outlet channel (18) so as to collect and process the filtered mixed liquid.

5. A method for separating L-5-methyltetrahydrofolate calcium, using a L-5-methyltetrahydrofolate calcium separation device according to any one of claims 1 to 4, characterized in that: The separation method comprises the following steps: S1. Take an appropriate amount of crude L-5-methyltetrahydrofolate calcium, put it into deionized water, heat and stir until it is evenly mixed with the deionized water, and then perform ultrasonic treatment; S2, heating the ultrasonically treated mixed solution to reflux; S3. The mixed solution after heating and refluxing is placed in a reaction kettle (10) for filtration and separation, and the separated crystals are then dried to obtain refined L-5-methyltetrahydrofolate calcium.

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