Preparation method of hydrophilic macromolecular organosilicon monomer for silicone hydrogel contact lenses

Abstract

The invention provides a preparation method of a hydrophilic macromolecular organosilicon monomer for silicone hydrogel contact lenses, which comprises the following steps: step 1, carrying out hydrosilylation reaction on hydrogen-terminated polydimethylsiloxane and polyethylene glycol diallyl ether in the presence of a platinum catalyst at the reaction temperature of 65-100 DEG C for 6-10 hours to obtain an intermediate 1; step 2, carrying out hydrosilylation reaction on the intermediate 1 and polyethylene glycol monoallyl ether at 60-90 DEG C for 5-8 hours, washing with water, and drying to obtain an intermediate 2; 3, the intermediate 2 is dissolved in dichloromethane and reacts with methacryloyl chloride at the temperature of 0-10 DEG C, the molar ratio of the intermediate 2 to methacryloyl chloride to an acid-binding agent triethylamine is 1: (2.0-2.5): (2.0-2.5), and after the reaction, a target product is obtained through concentration. According to the preparation method disclosed by the invention, a PEG chain segment is introduced in a block form, so that non-uniformity of a grafted structure is avoided, and synergistic improvement of hydrophilicity and oxygen permeability is realized.

Description

Technical Field

[0001] The invention relates to the technical field of organosilicon material synthesis, and in particular to a method for preparing a hydrophilic macromolecular organosilicon monomer for silicone hydrogel contact lenses. Background Art

[0002] Silicone hydrogel contact lenses are a combination of traditional hydrogel materials and silicone materials. They have the high oxygen permeability of silicone materials and the softness and hydrophilicity of hydrogel materials. Traditional hydrogel contact lenses have poor oxygen permeability. Long-term wearing will cause insufficient oxygen supply to the cornea, which can easily cause eye health problems. Silicone hydrogel contact lenses have a dual-channel material structure of silicon channels and water channels, which allows oxygen in the air to pass smoothly through the lens to the cornea, and have better oxygen permeability and wearing comfort.

[0003] Silicone hydrogel contact lenses combine the high oxygen permeability of silicone and the hydrophilicity of hydrogel, but the hydrophobicity of traditional polysiloxanes can easily lead to dryness when worn and lipid adsorption problems.

[0004] The existing technology (such as CN101932632A) modifies the siloxane main chain by grafting polyethylene glycol, but its structural stability is insufficient, and it is difficult to coordinately optimize the hydrophilicity and oxygen permeability. In addition, CN105457074A discloses block polysiloxane for medical dressings, but does not involve contact lens applications, and does not solve the problem of precise regulation of hydrophilic segments and siloxane blocks. Summary of the invention

[0005] The invention provides a method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses, so as to solve the defects in the prior art.

[0006] The present invention provides a method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses, comprising the following steps:

[0007] Step 1: subjecting hydrogen-terminated polydimethylsiloxane and polyethylene glycol diallyl ether to a hydrosilylation reaction in the presence of a platinum catalyst, wherein the molecular weight of the hydrogen-terminated polydimethylsiloxane is 2800-9300, the molecular weight of the polyethylene glycol diallyl ether is 1200-3200, and the molar ratio of the two is 1:2.00-2.05, the reaction temperature is 65-100° C., and the reaction time is 6-10 hours to obtain an intermediate 1;

[0008] Step 2: subjecting the intermediate 1 to a hydrosilylation reaction with polyethylene glycol monoallyl ether at 60-90° C., wherein the molecular weight of the polyethylene glycol monoallyl ether is 190-1000, and the molar ratio of the intermediate 1 to the polyethylene glycol monoallyl ether is 1:2.0-3.0, and the reaction time is 5-8 hours, and after washing with water and drying, an intermediate 2 is obtained;

[0009] Step 3: dissolving the intermediate 2 in dichloromethane, reacting with methacryloyl chloride at 0-10° C., wherein the molar ratio of the intermediate 2, methacryloyl chloride and acid-binding agent triethylamine is 1:2.0-2.5:2.0-2.5, and concentrating after the reaction to obtain the target product;

[0010] Among them, the structural formula of the target product is:

[0011] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O] n -[CH2

[0012] CH2O] q -COO(CH3)C=CH2

[0013] In the formula, n is an integer of 36-124, m is an integer of 24-70, and q is an integer of 3-21.

[0014] According to a method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses provided by the present invention, the platinum catalyst in step 1 is selected from platinum (0)-1,3-diethene-1,1,3,3-tetramethyldisiloxane or chloroplatinic acid, and the concentration of the catalyst in the reaction solution is 25-50 ppm.

[0015] According to the method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses provided by the present invention, the solvent in step 1 is selected from toluene, chlorobenzene or isopropanol.

[0016] According to the method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses provided by the present invention, the molecular weight of the polyethylene glycol monoallyl ether in step 2 is 320-500.

[0017] According to the method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses provided by the present invention, the reaction temperature in step 3 is 0-5° C., and the reaction time is 2 hours.

[0018] A silicone hydrogel contact lens comprises the hydrophilic macromolecular silicone monomer prepared by the method described above, wherein the mass percentage of the hydrophilic macromolecular silicone monomer in the formula is 25-60%.

[0019] According to a silicone hydrogel contact lens provided by the present invention, the formula further comprises the following components:

[0020] Polydimethylsiloxane methacrylate (PDMS-MA) 5-20%;

[0021] 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS) 5-15%;

[0022] N-vinylpyrrolidone (NVP) 20-35%;

[0023] Crosslinking agent: ethylene glycol dimethacrylate (EGDMA) 0.3-0.5%.

[0024] The silicone hydrogel contact lens provided by the present invention has a water content of 30-62%, an oxygen permeability coefficient (Dk) of 77-118 barrer, and a static water contact angle of 43-88°.

[0025] The present invention provides a method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses, wherein the PEG segment is introduced in the form of a block to avoid the unevenness of the grafted structure and achieve a synergistic improvement in hydrophilicity and oxygen permeability. The molecular segment length (n / m / q) is precisely regulated by a three-step reaction to ensure batch stability. The lens has a water content of 30% to 62%, an oxygen permeability coefficient (Dk) of 77 to 118 barrer, and a static water contact angle of 43 to 88°, which is significantly better than that of comparative document 1 (Dk=115, contact angle 44°). The prepared silicone monomer has good hydrophilicity through a silylation reaction and can effectively improve the comfort of silicone hydrogel contact lenses. The prepared silicone monomer can effectively improve the air permeability of contact lenses and make them more comfortable to wear. The present invention uses a silylation reaction to synthesize a hydrophilic macromolecular silicone monomer, with mild reaction conditions and simple steps, and has good prospects for industrial application. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, but not all of the embodiments. The components of the embodiments of the present invention described and shown herein can be arranged and designed in various different configurations.

[0027] Therefore, the detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0028] The present invention provides a method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses, comprising the following steps:

[0029] Step 1: subjecting hydrogen-terminated polydimethylsiloxane and polyethylene glycol diallyl ether to a hydrosilylation reaction in the presence of a platinum catalyst, wherein the molecular weight of the hydrogen-terminated polydimethylsiloxane is 2800-9300, the molecular weight of the polyethylene glycol diallyl ether is 1200-3200, and the molar ratio of the two is 1:2.00-2.05, the reaction temperature is 65-100° C., and the reaction time is 6-10 hours to obtain an intermediate 1;

[0030] Step 2: subjecting the intermediate 1 to a hydrosilylation reaction with polyethylene glycol monoallyl ether at 60-90° C., wherein the molecular weight of the polyethylene glycol monoallyl ether is 190-1000, and the molar ratio of the intermediate 1 to the polyethylene glycol monoallyl ether is 1:2.0-3.0, and the reaction time is 5-8 hours, and after washing with water and drying, an intermediate 2 is obtained;

[0031] Step 3: dissolving the intermediate 2 in dichloromethane, reacting with methacryloyl chloride at 0-10° C., wherein the molar ratio of the intermediate 2, methacryloyl chloride and acid-binding agent triethylamine is 1:2.0-2.5:2.0-2.5, and concentrating after the reaction to obtain the target product;

[0032] Among them, the structural formula of the target product is:

[0033] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O] n -[CH2

[0034] CH2O] q -COO(CH3)C=CH2

[0035] In the formula, n is an integer of 36-124, m is an integer of 24-70, and q is an integer of 3-21.

[0036] To further optimize the above technical solution, the platinum catalyst in step 1 is selected from platinum (0)-1,3-diethene-1,1,3,3-tetramethyldisiloxane or chloroplatinic acid, and the concentration of the catalyst in the reaction solution is 25-50 ppm.

[0037] To further optimize the above technical solution, the solvent in step 1 is selected from toluene, chlorobenzene or isopropanol.

[0038] To further optimize the above technical solution, the molecular weight of the polyethylene glycol monoallyl ether in step 2 is 320-500.

[0039] To further optimize the above technical solution, the reaction temperature in step 3 is 0-5°C and the reaction time is 2 hours.

[0040] A silicone hydrogel contact lens comprises the hydrophilic macromolecular silicone monomer prepared by the method described above, wherein the mass percentage of the hydrophilic macromolecular silicone monomer in the formula is 25-60%.

[0041] To further optimize the above technical solution, the formula also includes the following components:

[0042] Polydimethylsiloxane methacrylate (PDMS-MA) 5-20%;

[0043] 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS) 5-15%;

[0044] N-vinylpyrrolidone (NVP) 20-35%;

[0045] Crosslinking agent: ethylene glycol dimethacrylate (EGDMA) 0.3-0.5%.

[0046] To further optimize the above technical solution, the water content is 30-62%, the oxygen permeability coefficient (Dk) is 77-118 barrer, and the static water contact angle is 43-88°.

[0047] In order to more clearly and in detail introduce the method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses provided by the embodiments of the present invention, it will be described below in conjunction with specific embodiments.

[0048] Example 1

[0049] Step 1: Hydrogen-terminated polydimethylsiloxane (molecular weight 2800) and polyethylene glycol diallyl ether (molecular weight 1200) were subjected to hydrosilylation in the presence of a platinum catalyst (25 ppm) at a molar ratio of 1:2.00 and reacted at 65° C. for 6 hours to generate intermediate 1.

[0050] Step 2: Intermediate 1 and polyethylene glycol monoallyl ether (molecular weight 190) were reacted at a molar ratio of 1:2.0 at 60° C. for 5 hours, and the intermediate 2 was obtained after washing with water and drying.

[0051] Step 3: Intermediate 2 reacts with methacryloyl chloride at 2°C, with the molar ratio of intermediate 2, methacryloyl chloride and triethylamine being 1:2.0:2.0, to generate the target product, whose structural formula is:

[0052] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O]n -[CH2

[0053] CH2O] q -COO(CH3)C=CH2

[0054] Among them, n=36, m=24, q=3.

[0055] Example 2

[0056] Step 1: Hydrogen-terminated polydimethylsiloxane (molecular weight 9300) and polyethylene glycol diallyl ether (molecular weight 3200) were subjected to hydrosilylation in the presence of a platinum catalyst (50 ppm) at a molar ratio of 1:2.05 and reacted at 100° C. for 10 hours to generate intermediate 1.

[0057] Step 2: Intermediate 1 and polyethylene glycol monoallyl ether (molecular weight 1000) were reacted at a molar ratio of 1:3.0 at 90° C. for 8 hours, and the intermediate 2 was obtained after washing with water and drying.

[0058] Step 3: Intermediate 2 reacts with methacryloyl chloride at 10°C, with the molar ratio of intermediate 2, methacryloyl chloride and triethylamine being 1:2.5:2.5, to generate the target product, whose structural formula is:

[0059] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O] n -[CH2

[0060] CH2O] q -COO(CH3)C=CH2

[0061] Among them, n=124, m=70, q=21.

[0062] Example 3

[0063] Step 1: Hydrogen-terminated polydimethylsiloxane (molecular weight 4800) and polyethylene glycol diallyl ether (molecular weight 2500) were subjected to hydrosilylation in the presence of a platinum catalyst (40 ppm) at a molar ratio of 1:2.05 and reacted at 85° C. for 8 hours to generate intermediate 1.

[0064] Step 2: Intermediate 1 and polyethylene glycol monoallyl ether (molecular weight 190-1000) were reacted at a molar ratio of 1:2.5 at 80° C. for 6 hours, and the intermediate 2 was obtained by washing with water and drying.

[0065] Step 3: Intermediate 2 reacts with methacryloyl chloride at 5°C, with the molar ratio of intermediate 2, methacryloyl chloride and triethylamine being 1:2.5:2.0, to generate the target product, whose structural formula is:

[0066] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O] n -[CH2

[0067] CH2O] q -COO(CH3)C=CH2

[0068] Among them, n=74, m=51, q=14.

[0069] Example 4

[0070] Step 1: Hydrogen-terminated polydimethylsiloxane (molecular weight 5300) and polyethylene glycol diallyl ether (molecular weight 2200) were subjected to hydrosilylation in the presence of a platinum catalyst (30 ppm) at a molar ratio of 1:2.00 and reacted at 90° C. for 7 hours to generate intermediate 1.

[0071] Step 2: Intermediate 1 and polyethylene glycol monoallyl ether (molecular weight 800) were reacted at a molar ratio of 1:2.7 at 65° C. for 7 hours, and the intermediate 2 was obtained after washing with water and drying.

[0072] Step 3: Intermediate 2 reacts with methacryloyl chloride at 0-10°C, wherein the molar ratio of intermediate 2, methacryloyl chloride and triethylamine is 1:2.5:2.2 to generate the target product, whose structural formula is:

[0073] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O] n -[CH2

[0074] CH2O] q -COO(CH3)C=CH2

[0075] Among them, n=88, m=60, q=16.

[0076] Example 5

[0077] Step 1: Hydrogen-terminated polydimethylsiloxane (molecular weight 6500) and polyethylene glycol diallyl ether (molecular weight 2200) were subjected to hydrosilylation in the presence of a platinum catalyst (30 ppm) at a molar ratio of 1:2.00 and reacted at 80° C. for 8 hours to generate intermediate 1.

[0078] Step 2: Intermediate 1 and polyethylene glycol monoallyl ether (molecular weight 350) were reacted at a molar ratio of 1:2.4 at 85° C. for 6 hours, and the intermediate 2 was obtained by washing with water and drying.

[0079] Step 3: Intermediate 2 reacts with methacryloyl chloride at 0-10°C, wherein the molar ratio of intermediate 2, methacryloyl chloride and triethylamine is 1:2.5:2.0, to generate the target product, whose structural formula is:

[0080] CH2=C(CH3)COO-[CH2CH2O] q -[Si(CH3)2O] n -[CH2CH2O] m -[Si(CH3)2O] n -[CH2

[0081] CH2O] q -COO(CH3)C=CH2

[0082] Among them, n=105, m=33, q=12.

[0083] The following abbreviations are used in the following examples:

[0084] PDMS-MA: polydimethylsiloxane methacrylate;

[0085] TRIS: 3-methacryloxypropyl tris(trimethylsiloxy)silane;

[0086] NVP: N-vinylpyrrolidone;

[0087] EGDMA: crosslinker ethylene glycol dimethacrylate.

[0088] Example 6

[0089] Silicone Hydrogel Contact Lens Formula

[0090] The invention contains 25% to 60% of the above monomers, and is compounded with polydimethylsiloxane methacrylate (PDMS-MA, 5% to 20%), 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS, 5% to 15%), N-vinyl pyrrolidone (NVP, 20% to 35%) and a crosslinking agent EGDMA (0.3% to 0.5%).

[0091] The details are as follows:

[0092] Example 1 product: 30%

[0093] PDMS-MA: 20%

[0094] TRIS: 10%

[0095] NVP: 7%

[0096] EGDMA: 0.3%

[0097] The components are mixed in the mass ratio listed above, and the mixed solution is injected into the plastic mold using a liquid injection and mold closing machine, and the mold is closed at a certain injection pressure and speed. The completed mold is cured under the irradiation of an appropriate light source. After the curing is completed, the lens is taken out by a mold separation machine, and the obtained lens is washed with an alcohol / water solution in an appropriate ratio, and then washed with pure water several times, and finally placed in a storage solution for packaging and sterilization to obtain a silicone hydrogel contact lens.

[0098] Performance: Water content 30%, Dk = 116 barrer, contact angle 87°.

[0099] Example 7

[0100] Silicone Hydrogel Contact Lens Formula

[0101] The invention contains 25% to 60% of the above monomers, and is compounded with polydimethylsiloxane methacrylate (PDMS-MA, 5% to 20%), 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS, 5% to 15%), N-vinyl pyrrolidone (NVP, 20% to 35%) and a crosslinking agent EGDMA (0.3% to 0.5%).

[0102] The details are as follows:

[0103] Example 3 product: 60%

[0104] PDMS-MA: 5%

[0105] TRIS: 5%

[0106] NVP: 35%

[0107] EGDMA: 0.5%

[0108] The components are mixed in the mass ratio listed above, and the mixed solution is injected into the plastic mold using a liquid injection and mold closing machine, and the mold is closed at a certain injection pressure and speed. The completed mold is cured under the irradiation of an appropriate light source. After the curing is completed, the lens is taken out by a mold separation machine, and the obtained lens is washed with an alcohol / water solution in an appropriate ratio, and then washed with pure water several times, and finally placed in a storage solution for packaging and sterilization to obtain a silicone hydrogel contact lens.

[0109] Performance: Water content 62%, Dk=77barrer, contact angle 43°.

[0110] The present invention achieves a balanced optimization of hydrophilicity and oxygen permeability by means of block structure design, while maintaining high oxygen permeability (Dk≥77) and significantly reducing the contact angle (≤43°).

[0111] The monomer and formula of the present invention can be used to mass-produce contact lenses through an injection molding curing process. After being washed with alcohol / water and sterilized, the lenses meet the ISO18369-3 standard and are suitable for daily and monthly disposable types.

[0112] Therefore, the present invention provides a method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses, in which the PEG segment is introduced in the form of a block to avoid the unevenness of the grafted structure and achieve a synergistic improvement in hydrophilicity and oxygen permeability. The molecular segment length (n / m / q) is precisely regulated by a three-step reaction to ensure batch stability. The lens has a water content of 30% to 62%, an oxygen permeability coefficient (Dk) of 77 to 118 barrer, and a static water contact angle of 43 to 88°, which is significantly better than that of comparative document 1 (Dk = 115, contact angle 44°). The prepared silicone monomer has good hydrophilicity through a silylation reaction and can effectively improve the comfort of silicone hydrogel contact lenses. The prepared silicone monomer can effectively improve the air permeability of contact lenses and make them more comfortable to wear. The present invention uses a silylation reaction to synthesize a hydrophilic macromolecular silicone monomer, with mild reaction conditions and simple steps, and has good prospects for industrial application.

[0113] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses, characterized in that: The following steps are involved: Step 1: subjecting hydrogen-terminated polydimethylsiloxane and polyethylene glycol diallyl ether to a hydrosilylation reaction in the presence of a platinum catalyst, wherein the molecular weight of the hydrogen-terminated polydimethylsiloxane is 2800-9300, the molecular weight of the polyethylene glycol diallyl ether is 1200-3200, and the molar ratio of the two is 1:2.00-2.05, the reaction temperature is 65-100° C., and the reaction time is 6-10 hours to obtain an intermediate 1; Step 2: subjecting the intermediate 1 to a hydrosilylation reaction with polyethylene glycol monoallyl ether at 60-90° C., wherein the molecular weight of the polyethylene glycol monoallyl ether is 190-1000, and the molar ratio of the intermediate 1 to the polyethylene glycol monoallyl ether is 1:2.0-3.0, and the reaction time is 5-8 hours, and after washing with water and drying, an intermediate 2 is obtained; Step 3: dissolving the intermediate 2 in dichloromethane, reacting with methacryloyl chloride at 0-10° C., wherein the molar ratio of the intermediate 2, methacryloyl chloride and acid-binding agent triethylamine is 1:2.0-2.5:2.0-2.5, and concentrating after the reaction to obtain the target product; Among them, the structural formula of the target product is: <h2 style=";text-align:left;direction:ltr">CH2 = C(CH3)COO-[CH2CH2O]<h2 style=";text-align:left;direction:ltr"> q <h2 style=";text-align:left;direction:ltr"> -[Si(CH3)2O]<h2 style=";text-align:left;direction:ltr"> n <h2 style=";text-align:left;direction:ltr"> -[CH2CH2O]<h2 style=";text-align:left;direction:ltr"> m <h2 style=";text-align:left;direction:ltr"> -[Si(CH3)2O]<h2 style=";text-align:left;direction:ltr"> n <h2 style=";text-align:left;direction:ltr"> -[CH2 CH2O] q -COO(CH3)C=CH2 In the formula, n is an integer of 36-124, m is an integer of 24-70, and q is an integer of 3-21.

2. The method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses according to claim 1, characterized in that: The platinum catalyst in step 1 is selected from platinum (0)-1,3-diethene-1,1,3,3-tetramethyldisiloxane or chloroplatinic acid, and the concentration of the catalyst in the reaction solution is 25-50 ppm.

3. The method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses according to claim 1, characterized in that: The solvent in step 1 is selected from toluene, chlorobenzene or isopropanol.

4. The method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses according to claim 1, characterized in that: The molecular weight of the polyethylene glycol monoallyl ether in step 2 is 320-500.

5. The method for preparing a hydrophilic macromolecular silicone monomer for silicone hydrogel contact lenses according to claim 1, characterized in that: The reaction temperature in step 3 is 0-5°C, and the reaction time is 2 hours.

6. A silicone hydrogel contact lens, characterized in that: The hydrophilic macromolecular silicone monomer prepared by the method according to any one of claims 1 to 5 has a mass percentage of 25-60% in the formula.

7. The silicone hydrogel contact lens according to claim 6, characterized in that: The formulation also includes the following components: Polydimethylsiloxane methacrylate (PDMS-MA) 5-20%; 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS) 5-15%; N-vinylpyrrolidone (NVP) 20-35%; Crosslinking agent: ethylene glycol dimethacrylate (EGDMA) 0.3-0.5%.

8. The silicone hydrogel contact lens according to claim 7, characterized in that: Its water content is 30-62%, oxygen permeability coefficient (Dk) is 77-118 barrer, and static water contact angle is 43-88°.