Nucleic acid extractor

Abstract

The invention provides a nucleic acid extractor. The nucleic acid extractor comprises a main body bracket; the magnetic bar module comprises a fixing assembly and a magnetic bar assembly, the fixing assembly is movably connected to the main body support so that the magnetic bar module can move relative to the main body support, and the magnetic bar assembly is detachably connected with the fixing assembly in a clamping mode; the temperature control module is connected to the main body support, the temperature control module comprises a heating plate and an adapter, the heating plate is detachably connected with the adapter in a magnetic attraction mode, when the adapter carries a sample, the magnetic bar module can extract nucleic acid substances in the sample, and the nucleic acid substances in the sample can be extracted by the magnetic bar module. The heating plate is used for providing heat in the process of extracting the nucleic acid substances.

Description

Technical Field

[0001] The present application relates to the technical field of magnetic bead-based nucleic acid extraction equipment, and in particular to a nucleic acid extraction instrument. Background Art

[0002] The nucleic acid extractor uses the magnetic bead method to extract nucleic acids from samples. The nucleic acid extractor includes a magnetic bar module and a temperature control module. For different extraction fluxes and extraction volumes, the required magnetic bar module and temperature control module may be different. Therefore, during the operation of the nucleic acid extractor, it may be necessary to replace the magnetic bar module and the temperature control module. The current method of replacing the magnetic bar module and the temperature control module is inefficient, which is not conducive to controlling labor costs and increasing the speed of nucleic acid extraction. Summary of the invention

[0003] The present application provides a nucleic acid extraction instrument, comprising:

[0004] Main frame;

[0005] A magnetic bar module, comprising a fixing assembly and a magnetic bar assembly, wherein the fixing assembly is movably connected to the main body support so that the magnetic bar module can be displaced relative to the main body support, and the magnetic bar assembly is detachably connected to the fixing assembly by snapping; and

[0006] A temperature control module is connected to the main support, and the temperature control module includes a heating plate and an adapter. The heating plate and the adapter are detachably connected by magnetic attraction. When the adapter carries a sample, the magnetic rod module can extract the nucleic acid substance in the sample, and the heating plate is used to provide heat in the process of extracting the nucleic acid substance.

[0007] The above-mentioned nucleic acid extractor is used to extract nucleic acid substances in samples by magnetic bead method. The nucleic acid extractor includes a magnetic rod assembly and an adapter. For samples with different fluxes, different magnetic rod assemblies and different adapters need to be used. Therefore, when the sample flux changes, the magnetic rod assembly and the adapter in the nucleic acid extractor need to be replaced. In the above-mentioned nucleic acid extractor, the magnetic rod assembly is detachably connected to the fixed assembly by a snap-fitting manner. When installing or removing the magnetic rod assembly, it is only necessary to pull the magnetic rod assembly to release the snap-fitting state, thereby conveniently realizing the loading and unloading of the magnetic rod assembly. The heating plate and the adapter are detachably connected by magnetic attraction. When installing or removing the adapter, it is only necessary to place the adapter on the heating plate to fix the adapter on the heating plate. The adapter can be directly taken out by overcoming the magnetic force. Therefore, the above-mentioned nucleic acid extractor is conducive to improving the replacement speed and efficiency of the magnetic rod assembly and the adapter, thereby saving labor costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1 It is a schematic diagram of the three-dimensional structure of the nucleic acid extraction instrument according to an embodiment of the present application.

[0009] Figure 2 for Figure 1 Exploded view of the magnetic bar module.

[0010] Figure 3 for Figure 1 Schematic diagram of the partial cross-section structure of the middle magnetic rod module.

[0011] Figure 4 for Figure 1 Schematic diagram of the structure of the medium temperature control module.

[0012] Figure 5 for Figure 4 Exploded view of the adapter and heating plate.

[0013] Figure 6 for Figure 4 Another structural schematic diagram of the adapter.

[0014] Figure 7 It is a schematic diagram of the three-dimensional structure of a replaceable magnetic rod head.

[0015] Figure 8 It is a schematic diagram of the three-dimensional structure of a replaceable adapter.

[0016] Main component symbols

[0017] Nucleic acid extractor 100

[0018] Main frame 10

[0019] Bottom plate 11

[0020] Riser 12

[0021] First slider 13

[0022] The second slider 14

[0023] Track piece 15

[0024] Magnetic bar module 20

[0025] Fixing component 21

[0026] Fixed plate 211

[0027] Plunger base plate 212

[0028] Guide groove 2121

[0029] Plunger 213

[0030] Storage hole 2131

[0031] Card ball 214

[0032] Magnetic bar assembly 22, 200

[0033] Mounting plate 221

[0034] Magnetic bar 222, 201

[0035] Connector 223

[0036] Snap-in slot 2231

[0037] Convex Wing 2232

[0038] Temperature control module 30

[0039] Adapter 31, 300

[0040] Receiving slots 311, 301

[0041] The first positioning structure 312

[0042] Heating plate 32

[0043] Magnetic structure 321

[0044] The second positioning structure 322

[0045] The first driving member 41

[0046] The second driving member 42

[0047] The third driving member 43

[0048] Motor 431

[0049] Screw 432

[0050] Direction X, Y

[0051] The following specific implementation methods will further illustrate the present application in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0052] See also Figure 1 The nucleic acid extractor 100 of the embodiment of the present application is used to extract nucleic acid substances in a sample by magnetic bead method. The sample is a biological sample, such as a cell or tissue, and the nucleic acid substance is, for example, DNA or RNA.

[0053] The nucleic acid extractor 100 includes a main frame 10, a magnetic bar module 20 and a temperature control module 30. The magnetic bar module 20 and the temperature control module 30 are respectively movably connected to the main frame 10, and the main frame 10 is used to support the overall structure of the nucleic acid extractor 100 and maintain the relative position relationship between the functional modules (such as the magnetic bar module 20 and the temperature control module 30) in the nucleic acid extractor 100.

[0054] The temperature control module 30 is used to carry the sample, and the magnetic bar module 20 is used to extract the nucleic acid substance in the sample. During the process of extracting the nucleic acid substance, the magnetic bar module 20 and the temperature control module 30 can move relative to the main support 10.

[0055] In this embodiment, the main frame 10 includes a bottom plate 11 and a vertical plate 12. The bottom plate 11 is in the shape of a thin sheet, and the vertical plate 12 is connected to one surface of the bottom plate 11, and the bottom plate 11 and the vertical plate 12 are perpendicular to each other. The magnetic bar module 20 is movably connected to the vertical plate 12, and the temperature control module 30 is movably connected to the bottom plate 11.

[0056] The main frame 10 further includes a first slider 13, a second slider 14 and a track member 15. The track member 15 is fixedly disposed on the vertical plate 12. The track member 15 is in a long strip shape and extends in a direction perpendicular to the bottom plate 11, that is, it is parallel to the extension direction of the vertical plate 12. The first slider 13 and the second slider 14 are slidably connected to the track member 15 respectively.

[0057] The magnetic bar module 20 includes a fixing assembly 21, a magnetic bar assembly 22 and a magnetic bar cover assembly 23. The fixing assembly 21 is fixedly connected to the first slider 13, and the magnetic bar assembly 22 is detachably connected to the fixing assembly 21 in a snap-fit ​​manner. The magnetic bar cover assembly 23 is fixedly connected to the second slider 14.

[0058] The nucleic acid extractor 100 further includes a first driving member 41 and a second driving member 42. In this embodiment, the first driving member 41 is a screw stepping motor, and the second driving member 42 includes a motor.

[0059] The first driving member 41 is fixedly disposed on the vertical plate 12 and connected to the first slider 13, and is used to drive the first slider 13 to slide on the track member 15 along the extension direction of the track member 15 (that is, the direction perpendicular to the bottom plate 11, or parallel to the extension direction of the vertical plate 12), thereby synchronously driving the fixed component 21 fixed to the first slider 13 and the magnetic bar component 22 engaged with the fixed component 21 to move on the track member 15 along the extension direction of the track member 15.

[0060] The second driving member 42 is fixedly arranged on the surface of the base plate 11 connected to the vertical plate 12, and is connected to the second slider 14, and is used to drive the second slider 14 to slide on the track member 15 along the extension direction of the track member 15 (that is, the direction perpendicular to the base plate 11, or parallel to the extension direction of the vertical plate 12), thereby synchronously driving the magnetic rod sleeve assembly 23 fixed to the second slider 14 to move on the track member 15 along the extension direction of the track member 15.

[0061] Please also read Figure 1-Figure 3The fixed assembly 21 includes a fixed plate 211, a plunger base plate 212 and a plurality of plungers 213. The fixed plate 211 and the plunger base plate 212 are stacked, and the plunger base plate 212 is located between the fixed plate 211 and the base plate 11. One end of the fixed plate 211 is fixedly connected to the first slider 13, and the other end is fixedly connected to the plunger base plate 212 through a plurality of plungers 213. Each plunger 213 is a cylindrical structure having a receiving hole 2131. One end of each plunger 213 is partially embedded in the fixed plate 211, and the other end passes through the plunger base plate 212, so that the extension direction of the receiving hole 2131 of each plunger 213 is consistent with the stacking direction of the fixed plate 211 and the plunger base plate 212.

[0062] The fixing assembly 21 also includes a plurality of snap-fit ​​balls 214. The number of snap-fit ​​balls 214 is the same as that of the plungers 213 and they correspond one to one. Each snap-fit ​​ball 214 is at least partially located in the receiving hole 2131 of the corresponding plunger 213, and the receiving hole 2131 has an elastic member (not shown) inside to push the snap-fit ​​ball 214. One end of the elastic member is fixed to the hole wall of the receiving hole 2131, and the other end is fixedly connected to the snap-fit ​​ball 214. The elastic member is, for example, a spring. The position state of the snap-fit ​​ball 214 is variable, for example, the snap-fit ​​ball 214 can be completely retracted into the receiving hole 2131, or it can be partially located in the receiving hole 2131 and partially located outside the receiving hole 2131.

[0063] The magnetic bar assembly 22 includes a mounting plate 221, a plurality of magnetic bars 222 and a connecting member 223. The mounting plate 221 is in the shape of a rectangular thin plate as a whole, and each magnetic bar 222 is a cylinder. The height and diameter of each magnetic bar 222 are the same, and each magnetic bar 222 is fixedly arranged on the same surface of the mounting plate 221. Each magnetic bar 222 is spaced apart from each other and parallel to each other. The extension direction of each magnetic bar 222 is perpendicular to the plane where the mounting plate 221 is located, that is, the extension direction of each magnetic bar 222 is perpendicular to the bottom plate 11 and parallel to the vertical plate 12.

[0064] The connecting piece 223 is fixedly connected to the surface of the mounting plate 221 away from the magnetic rods 222. That is, the mounting plate 221 is located between the connecting piece 223 and the plurality of magnetic rods 222. The connecting piece 223 is engaged with the plunger bottom plate 212 so that the magnetic rod assembly 22 is fixed to the fixing assembly 21. When the magnetic rod assembly 22 is fixed to the fixing assembly 21, the plunger bottom plate 212 is located between the fixing plate 211 and the connecting piece 223.

[0065] A guide groove 2121 is provided on the surface of the plunger bottom plate 212 near the connecting member 223. In this embodiment, the guide groove 2121 is a "T"-shaped groove. Both sides of the connecting member 223 extend to form convex wings 2231 that can cooperate with the guide groove 2121, so that the connecting member 223 can be engaged in the guide groove 2121 through the convex wings 2231. In this embodiment, the guide groove 2121 extends linearly in a direction parallel to the bottom plate 11, and the connecting member 223 can move linearly in the guide groove 2121 along the extension direction of the guide groove 2121.

[0066] The fixing assembly 21 further includes a limit block 215. The limit block 215 is fixedly arranged at one end of the guide groove 2121 close to the vertical plate 12. When the magnetic bar assembly 22 is installed to the fixing assembly 21, the connecting member 223 is pushed into the guide groove 2121 from the other end thereof, and moves along the extension direction of the guide groove 2121 until it stops when it abuts against the limit block 215. Therefore, the limit block 215 is used to limit the depth of the connecting member 223 pushed into the guide groove 2121.

[0067] When the connecting member 223 and the plunger bottom plate 212 are not engaged, each engaging ball 214 is partially located inside the receiving hole 2131 and partially located outside the receiving hole 2131 under the action of elastic force. When the connecting member 223 contacts the engaging ball 214 and continues to move in the direction X of the limit block 215 in the guide groove 2121 during the process of pushing the connecting member 223 into the guide groove 2121, the engaging ball 214 is gradually contracted and recovered into the receiving hole 2131 under force. A plurality of engaging grooves 2231 corresponding to the engaging balls 214 are provided on the surface of the connecting member 223 close to the plunger bottom plate 212. When the connecting member 223 moves in the guide groove 2121 to the position corresponding to the engaging groove 2231 and the engaging ball 214, the engaging ball 214 falls into the engaging groove 2231. When the connecting member 223 moves to abut against the limit block 215, all the engaging balls 214 fall into the corresponding engaging grooves 2231, and the connecting member 223 engages with the plunger bottom plate 212, so that the magnetic bar assembly 22 is installed on the fixing assembly 21. When the magnetic bar assembly 22 needs to be removed, the magnetic bar assembly 22 can be pulled out in the direction Y away from the limit block 215 along the extension direction of the guide groove 2121.

[0068] Please also read Figure 1 and see Figure 4The temperature control module 30 includes an adapter 31 and a heating plate 32. The adapter 31 and the heating plate 32 are stacked, and the adapter 31 is located on the surface of the heating plate 32 away from the bottom plate 11. A plurality of receiving grooves 311 arranged at intervals are formed on the surface of the adapter 31 away from the heating plate 32. Each receiving groove 311 is a cylindrical groove with the same diameter and the same depth. Each receiving groove 311 is generally used to accommodate a nucleic acid extraction tube, which accommodates samples, eluents, etc. in the process of extracting nucleic acid substances by the magnetic bead method. The heating plate 32 is used to transfer heat to the adapter 31 so that the samples, eluents, etc. on the adapter 31 reach a preset temperature.

[0069] The nucleic acid extractor 100 further includes a third driving member 43, which includes a motor 431 and a lead screw 432. The motor 431 is fixedly disposed on the surface of the bottom plate 11 away from the vertical plate 12, and the lead screw is connected to the motor 431 and passes through the bottom plate 11 and extends toward the magnetic rod module 20 in a direction perpendicular to the bottom plate 11. The motor 431 is connected to the temperature control module 30, and is used to drive the temperature control module 30 to move along the extension direction of the lead screw 432.

[0070] See also Figure 5 In this embodiment, the adapter 31 is detachably fixed to the heating plate 32 by magnetic attraction.

[0071] The projections of the adapter 31 and the heating plate 32 on the bottom plate 11 are both roughly rectangular, and a magnetic attraction structure 321 is fixed at the four corners of the surface of the heating plate 32 close to the adapter 31. The adapter 31 is at least partially made of a material that can be magnetically adsorbed. When the adapter 31 is stacked on the heating plate 32, it is adsorbed on the heating plate 32 due to the magnetic force of the magnetic attraction structure 321. In this embodiment, the magnetic attraction structure 321 can be a magnet, and the adapter 31 is at least partially made of metal material.

[0072] Please also read Figure 5 and Figure 6 A first positioning structure 312 is formed on the surface of the adapter 31 close to the heating plate 32, and a second positioning structure 322 is formed on the surface of the heating plate 32 close to the adapter 31. The first positioning structure 312 and the second positioning structure 322 have a structure that cooperates with each other, so that the adapter 31 and the heating plate 32 are docked in a correct position relationship. In this embodiment, the first positioning structure 312 on the adapter 31 is a through hole, and the second positioning structure 322 on the heating plate 32 is a pin.

[0073] When installing the adapter 31 on the heating plate 32, it is only necessary to bring the adapter 31 close to the surface of the heating plate 32 away from the bottom plate 11, and dock the first positioning structure 312 with the second positioning structure 322, so that the adapter 31 and the heating plate 32 can be docked. Since the heating plate 32 is provided with a magnetic attraction structure 321, the adapter 31 is adsorbed and fixed on the heating plate 32 by magnetic force. When removing the adapter 31, it is only necessary to overcome the magnetic force of the magnetic attraction structure 321 and remove the adapter 31 from the heating plate 32.

[0074] Please also read Figures 1 to 5 In this embodiment, the magnetic bar assembly 22 includes 24 magnetic bars 222, and correspondingly, 24 receiving grooves 311 are formed on the adapter 31. The arrangement of the 24 magnetic bars 222 is consistent with the arrangement of the 24 receiving grooves 311, so that when the magnetic bar assembly 22 moves toward the temperature control module 30, each magnetic bar 222 can extend into a receiving groove 311 one by one.

[0075] In the process of extracting nucleic acid substances by magnetic bead method: each receiving groove 311 of the adapter 31 contains a sample, and magnetic beads are added to each sample after lysis, so that the free nucleic acid substances in the sample after lysis can be adsorbed on the magnetic beads; the magnetic rod sleeve module 23 grabs the magnetic rod sleeve array, so that a magnetic rod sleeve is sleeved on the outer surface of each magnetic rod 222; the magnetic rod module 20 is driven to move toward the temperature control module 30 on the track member 15 until each magnetic rod 222 with a magnetic rod sleeve is extended into a corresponding sample, so that the magnetic beads in each sample can be adsorbed to the outer surface of the magnetic rod sleeve; the magnetic rod module 20 adsorbed with magnetic beads is removed, and the sample carried on the adapter 31 is replaced with an eluent, and the magnetic rod module 20 adsorbed with magnetic beads is moved toward the adapter 31, so that the magnetic rod 222 and the magnetic rod sleeve are extended into the corresponding eluent, and the magnetic rod 222 is removed, so that the magnetic beads adsorbed with nucleic acid substances are left in the eluent; the nucleic acid substances are eluted from the magnetic beads, and pure nucleic acid substances can be obtained.

[0076] The sample throughput characterizes the number of samples that can be operated simultaneously in a single extraction process. The higher the sample throughput, the higher the extraction efficiency. In this embodiment, the magnetic rod assembly 22 includes 24 magnetic rods, and 24 receiving slots 311 are formed on the adapter 31. The above structure enables the nucleic acid extractor 100 to operate 24 samples simultaneously in a single extraction process.

[0077] When the required sample throughput is different, it is necessary to replace the magnetic rod assembly 22 and the adapter 31. For example, the magnetic rod assembly 22 can be replaced with Figure 7 The magnetic bar assembly 200 shown in FIG. 1 and the adapter 31 is replaced with a magnetic bar assembly 200 shown in FIG. Figure 8The adapter 300 shown. The magnetic rod assembly 200 includes 96 magnetic rods 201, and the adapter 300 is correspondingly formed with 96 receiving slots 301, so that the nucleic acid extraction instrument 100 after replacing the magnetic rod assembly 22 and the adapter 31 can simultaneously operate 96 samples in a single extraction process.

[0078] In other embodiments of the present application, the connecting member 223 may be integrally formed with the mounting plate 221. That is, a structure that can cooperate with the guide groove 2121 may be formed by the surface of the mounting plate 221 away from the fixing assembly 21. In this embodiment, the connecting member 223 and the mounting plate 221 are separate structures, and the two are fixedly connected, which is conducive to simplifying the manufacturing process.

[0079] In other embodiments of the present application, the temperature control module 30 may be fixedly disposed on the bottom plate 11, and the nucleic acid extractor 100 does not include the third driving member 43. In this embodiment, the temperature control module 30 is movably connected to the bottom plate 11, which is conducive to the coordinated movement of the temperature control module 30 and the magnetic bar module 20 during the extraction of nucleic acid substances, thereby facilitating the extraction.

[0080] In other embodiments of the present application, a magnetic attraction structure may be formed on the surface of the adapter 31 close to the heating plate 32, while no magnetic attraction structure is formed on the heating plate 32, and the heating plate 32 is at least partially formed of a material that can be magnetically attracted. In other embodiments of the present application, magnetic attraction structures may be fixed on the opposing surfaces of the adapter 31 and the heating plate 32, and the magnetic attraction structure on the adapter 31 and the magnetic attraction structure on the heating plate 32 have opposite magnetic properties. In this case, the adapter 31 and the heating plate 32 do not need to be set as materials that can be magnetically attracted, and the adapter 31 and the heating plate 32 are fixed to each other by their respective magnetic attraction structures.

[0081] In other embodiments of the present application, the number of magnetic rods 222 may be other, the number of receiving slots 311 in the adapter 31 may be other, and the magnetic rods 222 and the receiving slots 311 may be kept in one-to-one correspondence. In other embodiments of the present application, the number of plungers 213 may be other, the number of engaging balls 214 may be other, and the number of engaging slots 2231 may be other, and the plungers 213, the engaging balls 214, and the engaging slots 2231 may be kept in one-to-one correspondence. The positions of the plungers 213, the engaging balls 214, and the engaging slots 2231 may also be different, and they may correspond to each other. In other embodiments of the present application, the number and installation positions of the magnetic attraction structures 321 may be different, and the magnetic attraction adapter 31 may be realized. In other embodiments of the present application, the specific structures and positions of the first positioning structure 312 and the second positioning structure 322 may be different, and they may be fixed to each other in structural matching.

[0082] In the nucleic acid extractor 100 of the embodiment of the present application, the magnetic bar assembly 22 is detachably connected to the fixed assembly 21 by a snap-fitting manner; when installing the magnetic bar assembly 22, it is only necessary to push the magnetic bar assembly 22 into the guide groove 2121 to fix the magnetic bar assembly 22 to the fixed assembly 21; when removing the magnetic bar assembly 22, it is only necessary to pull the magnetic bar assembly 22 to release the snap-fitting state, thereby conveniently realizing the removal of the magnetic bar assembly 22. The adapter 31 is detachably connected to the heating plate 32 by magnetic attraction; when installing the adapter 31, it is only necessary to contact the adapter 31 with the heating plate 32, and the adapter 31 can be adsorbed to the heating plate 32 by magnetic force; when removing the adapter 31, it is only necessary to overcome the magnetic force to directly take out the adapter 31. Therefore, the nucleic acid extractor 100 of the present embodiment is conducive to improving the replacement speed and efficiency of the magnetic bar assembly 22 and the adapter 31, thereby saving labor costs.

[0083] Those skilled in the art should recognize that the above embodiments are only used to illustrate the present application and are not intended to be limiting of the present application. As long as they are within the spirit and scope of the present application, appropriate changes and modifications to the above embodiments are within the scope of protection claimed in the present application.

Claims

1. A nucleic acid extraction instrument, characterized in that: include: Main frame; The magnetic bar module comprises a fixing assembly and a magnetic bar assembly, wherein the fixing assembly is movably connected to the main body bracket so that the magnetic bar module can be displaced relative to the main body bracket, and the magnetic bar assembly is detachably connected to the fixing assembly by a snap-fitting manner; as well as A temperature control module is connected to the main support, and the temperature control module includes a heating plate and an adapter. The heating plate and the adapter are detachably connected by magnetic attraction. When the adapter carries a sample, the magnetic rod module can extract the nucleic acid substance in the sample, and the heating plate is used to provide heat in the process of extracting the nucleic acid substance.

2. The nucleic acid extractor according to claim 1, characterized in that: The fixing assembly is formed with a guide groove and a snap-fit ​​ball, and the magnetic bar assembly includes a connecting piece, and a plurality of snap-fit ​​holes are formed on the connecting piece; The connecting member can be displaced in the guide groove to engage the magnetic bar assembly with the fixing assembly, or to remove the magnetic bar assembly from the fixing assembly; When the magnetic bar assembly is engaged with the fixing assembly, the engaging ball is at least partially accommodated in the engaging hole so that the magnetic bar assembly is fixed to the fixing assembly.

3. The nucleic acid extractor according to claim 2, characterized in that: The fixing assembly comprises a plunger base plate and a plunger, wherein the plunger penetrates the plunger base plate and is formed with a receiving hole; When the magnetic bar assembly is engaged with the fixing assembly, the engaging ball is partially located in the receiving hole and partially located in the engaging hole.

4. The nucleic acid extractor according to claim 3, characterized in that: The fixing assembly further comprises a fixing plate, and the fixing plate is fixedly connected to the main support; One end of the plunger passes through the plunger bottom plate, and the other end is embedded in the fixing plate to fix the plunger bottom plate and the fixing plate.

5. The nucleic acid extractor according to claim 2, characterized in that: The fixing assembly includes a limit block located at one end of the guide groove, and the connecting member can be pushed into the guide groove from the other end of the guide groove. The limit block is used to limit the depth of the connecting member pushed into the guide groove.

6. The nucleic acid extractor according to claim 2, characterized in that: The guide groove is a T-shaped groove.

7. The nucleic acid extractor according to claim 1, characterized in that: The heating plate and the adapter are stacked; Among them, one of the heating plate and the adapter is fixedly provided with a magnetic attraction structure, and the other is at least partially made of a material that can be magnetically adsorbed; or, the adapter and the heating plate are respectively fixedly provided with magnetic attraction structures, and the magnetic attraction structures on the heating plate and the adapter can attract each other to fix the heating plate and the adapter.

8. The nucleic acid extractor according to claim 7, characterized in that: The heating plate is provided with a first positioning structure, and the adapter is provided with a second positioning structure. When the heating plate and the adapter are stacked, the first positioning structure is butted against the second positioning structure.

9. The nucleic acid extractor according to any one of claims 1 to 8, characterized in that: The temperature control module is movably connected to the main body support.

10. The nucleic acid extractor according to claim 9, characterized in that: The main frame includes a bottom plate and a vertical plate, wherein the vertical plate is connected to a surface of the bottom plate and is perpendicular to the bottom plate; The magnetic bar module is movably connected to the vertical plate, and the temperature control module is movably connected to the bottom plate. The magnetic bar module and the temperature control module can be displaced relative to the vertical plate in a direction perpendicular to the bottom plate.

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