Swelling microneedle for tissue fluid extraction

Abstract

The invention discloses a swellable microneedle for tissue fluid extraction, and relates to the technical field of tissue fluid extraction, the swellable microneedle comprises a base and a microneedle adjusting assembly, the microneedle adjusting assembly is fixed at the edge of the surface of the base, a microneedle telescopic scale is arranged on the surface of a fixing ring, a disc cover is fixed on the surface of a ratchet disc, and the disc cover is fixed on the surface of the ratchet disc. An indicating groove is formed in the surface of the disc cover, a rotating cover is rotationally connected to the middle of the surface of the base through a damping rotating shaft, a telescopic pipe is fixed to the end of the stress block, and a spring seat is fixed to one side of the outer wall of the center pipe. According to the swellable microneedle for extracting the tissue fluid, the disc cover is rotated by utilizing a ratchet wheel structure and a principle, so that the indicating groove in the surface of the disc cover is overlapped with a certain scale on the microneedle telescopic scale, and the extension distance of the microneedle is determined firstly, so that the extension distance of the microneedle is the overlapped scale on the indicating groove and the microneedle telescopic scale; therefore, the extension distance of the microneedle is accurately controlled, so that the phenomenon that the microneedle excessively extends to touch nerves and blood vessels to cause stabbing pain is prevented.

Description

Technical Field

[0001] The invention relates to the technical field of tissue fluid extraction, in particular to a swellable microneedle for tissue fluid extraction. Background Art

[0002] A swellable microneedle is a miniature needle-like structure made of a polymer material that can swell by absorbing tissue fluid. It is mainly used for non-invasive or minimally invasive extraction of tissue fluid (such as interstitial fluid) for biological analysis. The tip of the swellable microneedle is made of a swellable polymer material (such as polyacrylic acid, polyvinyl alcohol, sodium alginate, etc.), which is hydrophilic and can absorb tissue fluid and swell, while the needle body is made of a non-swellable material (such as polylactic acid, polycaprolactone, etc.) to provide mechanical support, and the base is used to fix the microneedle array, usually combined with a detection sensor or subsequent analysis equipment.

[0003] The microneedle array of existing swellable microneedles can adjust the extension distance by rotating the knob clockwise or counterclockwise, and the microneedles can be pressed to penetrate the epidermis of the skin. However, the extension distance of the microneedles is difficult to control accurately, which makes it easy for the microneedles to extend excessively and touch the nerves and blood vessels, causing pain.

[0004] Therefore, in view of this, the existing structure and defects are studied and improved, and a swellable microneedle for tissue fluid extraction is proposed. Summary of the invention

[0005] In view of the deficiencies of the prior art, the present invention provides a swellable microneedle for tissue fluid extraction, which solves the problems raised in the above-mentioned background technology.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions: a swellable microneedle for tissue fluid extraction, comprising a base and a microneedle adjustment component, wherein the microneedle adjustment component is fixed at the edge of the surface of the base, and the microneedle adjustment component comprises a fixing ring, an elastic pawl, a ratchet disk, a microneedle telescopic scale, a disk cover, an indicator groove, a rotating cover, a spring seat, a card, a central tube, a spiral push groove, a force block and a telescopic tube, wherein the inner side surface of the fixing ring is provided with an elastic pawl, and the inside of the fixing ring is provided with a ratchet disk, the surface of the fixing ring is provided with a microneedle telescopic scale, the surface of the ratchet disk is fixed with a disk cover, and the surface of the disk cover is provided with an indicator groove, the middle part of the surface of the base is rotatably connected with the rotating cover through a damping shaft, and the middle part of the inner wall of the rotating cover is fixed with a central tube, the inner wall of the central tube is provided with a spiral push groove, and the inside of the spiral push groove is slidably connected with a force block, the end of the force block is fixed with a telescopic tube, one side of the outer wall of the central tube is fixed with a spring seat, and the end of the spring seat is fixed with a card.

[0007] Furthermore, the ratchet disc is rotatably connected to the surface of the base, and the outer diameter of the disc cover is larger than the outer diameter of the ratchet disc, and the bottom surface of the disc cover is in contact with the surface of the fixing ring.

[0008] Furthermore, the card passes through the side surface of the rotating cover, and the card and the indicating groove are engaged with each other, and the card is elastically connected to the central tube and the rotating cover through a spring seat.

[0009] Furthermore, the microneedle adjustment assembly also includes a plug post and a substrate. The plug post is inserted into the telescopic tube, and the substrate is fixed to the end of the plug post.

[0010] Furthermore, the substrate is located inside the base, and the outer opening structure size of the substrate is matched with the inner opening size of the base.

[0011] Furthermore, the microneedle adjustment assembly also includes a needle body, and the surface of the substrate is provided with the needle bodies in a matrix shape.

[0012] Furthermore, the microneedle adjustment assembly also includes a needle tip, and the end of the needle body is fixed with the needle tip.

[0013] Furthermore, a bracket is fixed inside the base, and there is a distance between the bracket and the top of the inner wall of the base.

[0014] Furthermore, the surface of the support is provided with needle sleeves in a matrix shape, and the interior of the needle sleeves is penetrated by needle bodies and needle tips.

[0015] Furthermore, the swellable microneedle for tissue fluid extraction includes the following steps: Step 1: Press the card to retract it into the rotating cover, and then manually rotate the disc cover to make the ratchet disc with it rotate clockwise along the inner side of the fixed ring through the elastic pawl, so that the indicator groove coincides with a certain scale on the microneedle telescopic ruler, which indicates the size of the needle body carrying the needle tip that can be extended; Step 2: After the indicator groove on the surface of the disk cover is separated from the card, the pressure on the card can be released, and then the rotating cover is manually rotated counterclockwise until the card is stuck in the indicator groove under the elastic action of the spring seat; Step 3: When the rotating cover rotates, the central tube drives the force block to slide through the spiral push groove, so that the telescopic tube extends, and the telescopic tube carries the plug column and the base plate to make the needle body and the needle tip extend along the inside of the needle sleeve, and the extension distance of the needle body and the needle tip is consistent with the scale overlapped on the indicator groove and the microneedle telescopic scale; Step 4: Manually press the base to make the needle body carry the needle tip into the skin. The needle tip is made of one or more of methacrylated gelatin, methacrylated hyaluronic acid, methacrylated dextran, methacrylated sodium alginate, methacrylated silk fibroin, methacrylated chondroitin sulfate, methacrylated chitosan, methacrylated heparin, methacrylated polyvinyl alcohol, polyether F127 diacrylate, and polyethylene glycol diacrylate. The needle tip is hydrophilic and can absorb tissue fluid and swell, so that biomarkers such as glucose, metabolites, and proteins in the interstitial fluid are enriched in the needle tip material. Step 5: Manually press the card to retract it into the rotating cover and rotate the rotating cover clockwise to retract the needle body and needle tip into the needle sleeve, while the external detection sensor or analysis equipment on the base detects and analyzes the biomarkers enriched in the needle tip.

[0016] The present invention provides a swellable microneedle for tissue fluid extraction, which has the following beneficial effects: 1. The swellable microneedle for tissue fluid extraction uses a ratchet structure and principle to rotate the disc cover so that the indicator groove on its surface coincides with a certain scale on the microneedle telescopic ruler, thereby first determining the extension distance of the microneedle, and then rotating the rotating cover until the card on the side is inserted into the indicator groove. When the rotating cover is rotated, the microneedle is extended synchronously, and when the card is inserted into the indicator groove, the microneedle stops extending. At this time, the extension distance of the microneedle is the scale on which the indicator groove coincides with the microneedle telescopic ruler, thereby accurately controlling the extension distance of the microneedle to prevent the microneedle from excessively extending and touching nerves and blood vessels, thereby causing tingling. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the top structure of a base of a swellable microneedle for tissue fluid extraction according to the present invention; Figure 2 This is a schematic diagram of the bottom structure of a base of a swellable microneedle for tissue fluid extraction according to the present invention; Figure 3 This is a schematic diagram of the central tube structure of a swellable microneedle for tissue fluid extraction according to the present invention; Figure 4 This is a schematic diagram of the substrate structure of a swellable microneedle for tissue fluid extraction according to the present invention; Figure 5 This is a schematic diagram of a support structure of a swellable microneedle for tissue fluid extraction according to the present invention; Figure 6 The schematic diagram is a needle tip structure of a swellable microneedle for tissue fluid extraction according to the present invention.

[0018] In the figure: 1. base; 2. microneedle adjustment component; 201. fixing ring; 202. elastic pawl; 203. ratchet disk; 204. microneedle telescopic scale; 205. disk cover; 206. indicator slot; 207. rotating cover; 208. spring seat; 209. card; 210. center tube; 211. spiral push groove; 212. force block; 213. telescopic tube; 214. plug post; 215. substrate; 216. needle body; 217. needle tip; 3. bracket; 4. needle sleeve. DETAILED DESCRIPTION

[0019] The following embodiments of the present invention are described in further detail in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0020] like Figure 1-Figure 6As shown, the present invention provides a technical solution: a swellable microneedle for tissue fluid extraction, comprising a base 1 and a microneedle adjustment component 2, the microneedle adjustment component 2 is fixed at the edge of the surface of the base 1, and the microneedle adjustment component 2 comprises a fixing ring 201, an elastic pawl 202, a ratchet disk 203, a microneedle telescopic scale 204, a disk cover 205, an indicator groove 206, a rotating cover 207, a spring seat 208, a card 209, a central tube 210, a spiral push groove 211, a force block 212 and a telescopic tube 213, the inner side of the fixing ring 201 is provided with an elastic pawl 202, and the inner side of the fixing ring 201 is provided with a A ratchet disc 203 is arranged at the top, a microneedle telescopic scale 204 is arranged on the surface of the fixing ring 201, a disc cover 205 is fixed on the surface of the ratchet disc 203, and an indicating groove 206 is provided on the surface of the disc cover 205, a rotating cover 207 is rotatably connected to the middle part of the surface of the base 1 through a damping shaft, and a central tube 210 is fixed to the middle part of the inner wall of the rotating cover 207, a spiral push groove 211 is provided on the inner wall of the central tube 210, and a force block 212 is slidably connected inside the spiral push groove 211, a telescopic tube 213 is fixed to the end of the force block 212, and a spring seat is fixed to one side of the outer wall of the central tube 210 208, and a card 209 is fixed at the end of the spring seat 208, the ratchet disc 203 is rotatably connected to the surface of the base 1, and the outer diameter of the disc cover 205 is larger than the outer diameter of the ratchet disc 203, and the bottom surface of the disc cover 205 is in contact with the surface of the fixed ring 201, the card 209 passes through the side of the rotating cover 207, and the card 209 and the indicating groove 206 are mutually engaged, and the card 209 is elastically connected to the central tube 210 and the rotating cover 207 through the spring seat 208, the microneedle adjustment component 2 also includes a plug post 214 and a base plate 215, the plug post 214 is inserted into the telescopic tube 213, and the plug post A substrate 215 is fixed to the end of 214, the substrate 215 is located inside the base 1, and the outer opening structure size of the substrate 215 is adapted to the inner opening size of the base 1, the microneedle adjustment component 2 also includes a needle body 216, the surface of the substrate 215 is provided with the needle body 216 in a matrix shape, the microneedle adjustment component 2 also includes a needle tip 217, the end of the needle body 216 is fixed with the needle tip 217, the inside of the base 1 is fixed with a bracket 3, and there is a spacing between the bracket 3 and the top of the inner wall of the base 1, the surface of the bracket 3 is provided with a needle sleeve 4 in a matrix shape, and the inside of the needle sleeve 4 is penetrated with the needle body 216 and the needle tip 217; The specific operation is as follows: first, determine the distance that the needle body 216 and the needle tip 217 need to extend, and based on the distance, manually press the card 209 to retract it into the rotating cover 207, so that the card 209 is separated from the indicator slot 206, and then manually rotate the disk cover 205 to carry the ratchet disk 203 along the inner side of the fixing ring 201 through the elastic ratchet 202 to make the indicator slot 206 coincide with the scale on the microneedle telescopic ruler 204, which indicates the size that the needle body 216 carrying the needle tip 217 can extend, and the indicator slot 206 on the surface of the disk cover 205 and the card 20 After separation, the card 209 can be released, and then the rotating cover 207 can be manually rotated counterclockwise until the card 209 is inserted into the indicating groove 206 under the elastic action of the spring seat 208. When the rotating cover 207 rotates, the central tube 210 drives the force block 212 to slide through the spiral push groove 211, so that the telescopic tube 213 is extended, and the telescopic tube 213 carries the plug column 214 and the base plate 215 to make the needle body 216 and the needle tip 217 extend along the inside of the needle sleeve 4, and the extension distance of the needle body 216 and the needle tip 217 is consistent with the scale overlapped on the indicating groove 206 and the microneedle telescopic ruler 204; The ratchet disc 203 can only rotate in one direction clockwise, while the rotating cover 207 rotates counterclockwise when the needle body 216 and the needle tip 217 are extended. During this process, even if the card 209 is attached to the inner side of the disc cover 205 and slides, it cannot drive the disc cover 205 to rotate clockwise, thereby ensuring that the indicator slot 206 always coincides with the specified scale. Based on the above description, the present invention utilizes the ratchet structure and principle to rotate the disk cover 205 so that the indicator groove 206 on its surface coincides with a certain scale on the microneedle telescopic scale 204, thereby first determining the extension distance of the microneedle, and then rotating the rotating cover 207 until the card 209 on its side is inserted into the indicator groove 206. When the rotating cover 207 is rotated, the microneedle is synchronously extended, and when the card 209 is inserted into the indicator groove 206, the microneedle stops extending. At this time, the extension distance of the microneedle is the scale that coincides with the indicator groove 206 and the microneedle telescopic scale 204, thereby accurately controlling the extension distance of the microneedle to prevent the microneedle from excessively extending and touching the nerves and blood vessels, thereby causing tingling.

[0021] The swellable microneedle for tissue fluid extraction comprises the following steps: Step 1: Press the card 209 to retract it into the rotating cover 207, and then manually rotate the disk cover 205 to make it carry the ratchet disk 203 to rotate clockwise along the inner side of the fixing ring 201 through the elastic pawl 202, so that the indicator groove 206 coincides with a certain scale on the microneedle extension scale 204, and the scale indicates the size that the needle body 216 carrying the needle tip 217 can extend; Step 2: After the indicator groove 206 on the surface of the disk cover 205 is separated from the card 209, the pressure on the card 209 can be released, and then the rotating cover 207 is manually rotated counterclockwise until the card 209 is inserted into the indicator groove 206 under the elastic action of the spring seat 208; Step 3: When the rotating cover 207 rotates, the central tube 210 drives the force block 212 to slide through the spiral push groove 211, so that the telescopic tube 213 extends, and the telescopic tube 213 carries the plug post 214 and the base plate 215 to make the needle body 216 and the needle tip 217 extend along the inside of the needle sleeve 4, and the extension distance of the needle body 216 and the needle tip 217 is consistent with the scale overlapped on the indicator groove 206 and the microneedle telescopic ruler 204; Step 4: Manually press the base 1 so that the needle body 216 carries the needle tip 217 into the skin. The needle tip 217 is made of one or more of methacrylated gelatin, methacrylated hyaluronic acid, methacrylated dextran, methacrylated sodium alginate, methacrylated silk fibroin, methacrylated chondroitin sulfate, methacrylated chitosan, methacrylated heparin, methacrylated polyvinyl alcohol, polyether F127 diacrylate, and polyethylene glycol diacrylate. The needle tip 217 is hydrophilic and can absorb tissue fluid and swell, so that biomarkers such as glucose, metabolites, and proteins in the interstitial fluid are enriched in the needle tip 217 material; Step 5: Manually press the card 209 to retract it into the rotating cover 207 and rotate the rotating cover 207 clockwise to retract the needle body 216 and the needle tip 217 into the needle sleeve 4, and the external detection sensor or analysis equipment of the base 1 detects and analyzes the biomarkers enriched in the needle tip 217.

[0022] The embodiments of the present invention are given for the purpose of illustration and description, and are not intended to be exhaustive or to limit the invention to the disclosed forms. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are selected and described in order to better illustrate the principles and practical applications of the present invention and to enable those of ordinary skill in the art to understand the present invention and thereby design various embodiments with various modifications suitable for specific uses.

Claims

1. A swellable microneedle for tissue fluid extraction, comprising a base (1) and a microneedle adjustment component (2), characterized in that: A microneedle adjustment component (2) is fixed at the edge of the surface of the base (1), and the microneedle adjustment component (2) comprises a fixing ring (201), an elastic pawl (202), a ratchet disk (203), a microneedle telescopic scale (204), a disk cover (205), an indicator groove (206), a rotating cover (207), a spring seat (208), a card (209), a central tube (210), a spiral push groove (211), a force block (212) and a telescopic tube (213), wherein the inner side surface of the fixing ring (201) is provided with an elastic pawl (202), and the inside of the fixing ring (201) is provided with a ratchet disk (203), and the surface of the fixing ring (201) is provided with a microneedle telescopic scale (204). 4), a disc cover (205) is fixed on the surface of the ratchet disc (203), and an indicating groove (206) is provided on the surface of the disc cover (205); a rotating cover (207) is rotatably connected to the middle of the surface of the base (1) via a damping shaft, and a center tube (210) is fixed to the middle of the inner wall of the rotating cover (207); a spiral push groove (211) is provided on the inner wall of the center tube (210), and a force block (212) is slidably connected inside the spiral push groove (211); a telescopic tube (213) is fixed to the end of the force block (212); a spring seat (208) is fixed to one side of the outer wall of the center tube (210), and a card (209) is fixed to the end of the spring seat (208).

2. A swellable microneedle for tissue fluid extraction according to claim 1, characterized in that: The ratchet disc (203) is rotatably connected to the surface of the base (1), the outer diameter of the disc cover (205) is larger than the outer diameter of the ratchet disc (203), and the bottom surface of the disc cover (205) is in contact with the surface of the fixing ring (201).

3. A swellable microneedle for tissue fluid extraction according to claim 1, characterized in that: The card (209) passes through the side of the rotating cover (207), and the card (209) and the indicating groove (206) are mutually engaged, and the card (209) is elastically connected to the central tube (210) and the rotating cover (207) via a spring seat (208).

4. A swellable microneedle for tissue fluid extraction according to claim 1, characterized in that: The microneedle adjustment assembly (2) further comprises an insertion column (214) and a base plate (215); the insertion column (214) is inserted into the interior of the telescopic tube (213), and the base plate (215) is fixed to the end of the insertion column (214).

5. A swellable microneedle for tissue fluid extraction according to claim 4, characterized in that: The substrate (215) is located inside the base (1), and the structural dimensions of the outer opening of the substrate (215) are matched to the dimensions of the inner opening of the base (1).

6. A swellable microneedle for tissue fluid extraction according to claim 4, characterized in that: The microneedle adjustment assembly (2) further comprises a needle body (216), and the surface of the substrate (215) is provided with the needle bodies (216) in a matrix shape.

7. A swellable microneedle for tissue fluid extraction according to claim 6, characterized in that: The microneedle adjustment assembly (2) further comprises a needle tip (217), and the needle tip (217) is fixed to the end of the needle body (216).

8. A swellable microneedle for tissue fluid extraction according to claim 7, characterized in that: A bracket (3) is fixed inside the base (1), and there is a distance between the bracket (3) and the top of the inner wall of the base (1).

9. A swellable microneedle for tissue fluid extraction according to claim 8, characterized in that: The surface of the support (3) is provided with needle sleeves (4) in a matrix shape, and the interior of the needle sleeves (4) is provided with needle bodies (216) and needle tips (217).

10. A swellable microneedle for tissue fluid extraction according to any one of claims 1 to 9, characterized in that: The swellable microneedle for tissue fluid extraction comprises the following steps: Step 1: Press the card (209) to retract it into the rotating cover (207), and then manually rotate the disk cover (205) to make the ratchet disk (203) with it rotate clockwise along the inner side of the fixing ring (201) through the elastic ratchet (202), so that the indicating groove (206) coincides with a certain scale on the microneedle extension scale (204), and the scale indicates the size that the needle body (216) carrying the needle tip (217) can extend; Step 2: After the indicator groove (206) on the surface of the disk cover (205) is separated from the card (209), the pressure on the card (209) can be released, and then the rotating cover (207) is manually rotated counterclockwise until the card (209) is inserted into the indicator groove (206) under the elastic action of the spring seat (208); Step 3: When the rotating cover (207) rotates, the central tube (210) drives the force block (212) to slide through the spiral push groove (211), thereby extending the telescopic tube (213), and the telescopic tube (213) carries the plug post (214) and the base plate (215) so that the needle body (216) and the needle tip (217) extend along the inside of the needle sleeve (4), and the extension distance of the needle body (216) and the needle tip (217) is consistent with the scales on the indicator groove (206) and the microneedle telescopic ruler (204) that overlap; Step 4: Manually press the base (1) so that the needle body (216) carries the needle tip (217) and penetrates the skin. The needle tip (217) is made of one or more of methacrylated gelatin, methacrylated hyaluronic acid, methacrylated dextran, methacrylated sodium alginate, methacrylated silk fibroin, methacrylated chondroitin sulfate, methacrylated chitosan, methacrylated heparin, methacrylated polyvinyl alcohol, polyether F127 diacrylate, and polyethylene glycol diacrylate, and the needle tip (217) is hydrophilic and can absorb tissue fluid and swell, so that biomarkers such as glucose, metabolites, and proteins in the interstitial fluid are enriched in the needle tip (217) material; Step 5: Manually press the card (209) to retract it into the interior of the rotating cover (207) and rotate the rotating cover (207) clockwise to retract the needle body (216) and the needle tip (217) into the needle sleeve (4), and the external detection sensor or analysis equipment of the base (1) detects and analyzes the biomarkers enriched in the needle tip (217).

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