Blood nourishing and nerve calming granule and preparation method thereof

Abstract

The invention relates to the technical field of medicine preparation, in particular to blood nourishing and nerve calming granules and a preparation method thereof.The method comprises the steps that first-class raw materials are sequentially soaked, decocted and filtered to output first-class liquid medicine and medicine residues, second-class raw materials are added into the medicine residues, decocted twice and filtered to output second-class liquid medicine; adding cane sugar and dextrin into the thick paste to output a soft material, granulating the soft material by using a granulator to output wet granules, drying the wet granules by using a drying oven to output dry granules, and mixing the selected dry granules by using a mixing cavity to output granules for nourishing blood and tranquilizing; the preparation stability of the blood-nourishing and nerve-calming granules is determined based on the elongation rate of the granulation time of the wet granules; if the preparation stability does not meet the requirement, adjusting an included angle between cutting knives in the granulator; and if the mixing effectiveness does not meet the requirement, adjusting the stirring mode of the dry particles. The preparation stability of the blood-nourishing and nerve-calming granules is improved.

Description

Technical Field

[0001] The invention relates to the technical field of drug preparation, and in particular to blood-nourishing and mind-calming granules and a preparation method thereof. Background Art

[0002] In the prior art, blood-nourishing and tranquilizing drugs have a wide and important market demand in today's society. With the accelerated pace of life, increased work pressure and the influence of various environmental factors, mental health problems such as insomnia, anxiety, neurasthenia, etc. are becoming increasingly common, seriously affecting people's quality of life and work efficiency. According to relevant medical research data, the incidence of insomnia is increasing year by year worldwide, and about one-third of adults have varying degrees of sleep disorders, and this proportion in my country should not be underestimated. In this context, blood-nourishing and tranquilizing drugs, as an effective means to alleviate such symptoms, have attracted the attention and favor of more and more consumers.

[0003] As a common oral preparation, Yangxue Anshen Granules occupy a certain market share due to its advantages such as convenient administration, easy absorption and definite efficacy. The traditional preparation method of Yangxue Anshen Granules has gradually exposed some problems in long-term practical applications. In the raw material processing stage, the soaking, decoction and filtration of raw materials are not refined enough, resulting in a low extraction rate of effective ingredients and serious waste of medicinal resources.

[0004] Chinese patent publication number: CN102614346A discloses a deer blood tranquilizing granule and a preparation method thereof, the method comprising the following steps: preparing raw materials according to the following weight portions: 60 parts of deer blood, 70 parts of Chinese yam, 30 parts of Chinese angelica, 60 parts of ginseng, 80 parts of Schisandra chinensis, 30 parts of Chinese date seeds, an appropriate amount of sucrose, and an appropriate amount of dextrin; washing, chopping, and boiling the above ginseng, Chinese yam, Schisandra chinensis, Chinese angelica, and Chinese date seeds; adding 8 times the amount of water for the first time and boiling for 2 hours; adding 6 times the amount of water for the second time and boiling for 1.5 hours; The extract is filtered and concentrated to an extract with a specific gravity of 1.2, which is measured at 80°C; the deer blood is initially processed through a 40-mesh sieve to prepare defibrinated blood protein, which is centrifuged at 1500 to 2000 revolutions per minute for 3 to 5 minutes to obtain plasma, and ultra-filtered at 5°C to 25°C to obtain slurry protein powder; the extract, slurry protein powder, sucrose, and dextrin are mixed at a weight ratio of 1:1:3:1 to obtain a mixture; the mixture is granulated through a 14-mesh sieve, dried, granulated, batch mixed, and packaged with a composite film. It can be seen that the deer blood tranquilizing granules and the preparation method thereof have the problem that the insulation skin of the motor winding in the granulator is aged and damaged, causing a short circuit, resulting in a decrease in the motor output power, resulting in uneven granulation and thus causing a decrease in the preparation stability of the blood-nourishing and tranquilizing granules. Summary of the invention

[0005] To this end, the present invention provides a blood-nourishing and calming-the-soul granule and a preparation method thereof, so as to overcome the problem in the prior art that the insulation skin of the motor winding in the granulator is aged and damaged, causing a short circuit, resulting in a decrease in the motor output power, resulting in uneven particle formation and thus causing a decrease in the preparation stability of the blood-nourishing and calming-the-soul granule.

[0006] To achieve the above-mentioned purpose, the present invention provides a preparation method of Yangxue Anshen Granules, comprising: soaking, decocting and filtering a first type of raw material in sequence to output a first type of medicinal liquid and medicinal residues, adding a second type of raw material to the medicinal residues and decocting twice and then filtering to output a second type of medicinal liquid, combining and concentrating the first type of medicinal liquid and the second type of medicinal liquid to output a thick paste; adding sucrose and dextrin to the thick paste to output a soft material, granulating the soft material with a granulator to output wet granules, drying the wet granules with an oven to output dry granules, and selecting the soft material with a mixing chamber. The dry granules are mixed to output Yangxue Anshen Granules; the granulation time of the wet granules is obtained; the preparation stability of the Yangxue Anshen Granules is determined based on the extension rate of the granulation time of the wet granules; if the preparation stability does not meet the requirements, the angle between the cutting knives in the granulator is adjusted, or the mixing effectiveness of the Yangxue Anshen Granules is determined based on the density of the Yangxue Anshen Granules per unit volume; if the mixing effectiveness does not meet the requirements, the stirring method of the dry granules is adjusted, or the drying batch size of the wet granules is adjusted based on the maximum temperature difference in the oven.

[0007] Further, determining the preparation stability of the Yangxue Anshen Granules comprises:

[0008] comparing the extension rate of the granulation time of the wet granules with a preset first extension rate;

[0009] If the extension rate of the granulation time of the wet granules is greater than the preset first extension rate, it is determined that the preparation stability of the Yangxue Anshen Granules does not meet the requirements.

[0010] Further, determining the mixed effectiveness of the Yangxue Anshen Granules includes:

[0011] comparing the extension rate of the granulation time of the wet granules with the preset first extension rate and the preset second extension rate respectively;

[0012] If the extension rate of the granulation time of the wet granules is greater than the preset first extension rate and less than or equal to the preset second extension rate, it is preliminarily determined that the mixing effectiveness of the Yangxue Anshen Granules does not meet the requirements, and whether the mixing effectiveness of the Yangxue Anshen Granules meets the requirements is determined based on the density of the Yangxue Anshen Granules in unit volume.

[0013] Further, adjusting the angle between the cutting blades in the granulator comprises:

[0014] comparing the extension rate of the granulation time of the wet granules with the preset second extension rate;

[0015] If the extension rate of the granulation time of the wet granules is greater than the preset second extension rate, the angle between the cutting knives in the granulator is increased.

[0016] Furthermore, the increase range of the angle between the cutting knives in the granulator is determined by the difference between the extension rate of the granulation time of the wet granules and a preset second extension rate.

[0017] Furthermore, the stirring mode of the dry particles is adjusted, including:

[0018] The density of the Yangxue Anshen granules in the unit volume is compared with the preset first density and the preset second density respectively;

[0019] If the density of the Yangxue Anshen Granules in the unit volume is less than or equal to the preset second density, it is determined that the mixing effectiveness of the Yangxue Anshen Granules does not meet the requirements;

[0020] If the density of the Yangxue Anshen granules in the unit volume is greater than the preset first density and less than or equal to the preset second density, adjusting the stirring mode of the dry granules;

[0021] If the density of the Yangxue Anshen Granules in the unit volume is greater than the preset first density, it is preliminarily determined that the drying effectiveness does not meet the requirements, and whether the drying effectiveness meets the requirements is determined based on the maximum temperature difference in the oven.

[0022] Furthermore, the stirring mode of the dry particles is adjusted from continuous stirring to alternating forward and reverse stirring.

[0023] Further, the drying batch size of the wet granules is adjusted, comprising:

[0024] comparing the maximum temperature difference in the oven with a preset difference;

[0025] If the maximum temperature difference in the oven is greater than the preset difference, it is determined that the drying effectiveness does not meet the requirements, and the drying batch size of the wet particles is reduced.

[0026] Furthermore, the reduction range of the drying batch size of the wet particles is determined by the difference between the maximum temperature difference in the oven and a preset temperature difference.

[0027] The present invention also provides a blood-nourishing and mind-calming granule, whose components and contents include: 100g of Polygonum multiflorum, 100g of Millettia spatholobi, 100g of Albizzia julibrissin, 100g of Rehmannia glutinosa, 100g of Rehmannia glutinosa, 167g of Agrimoniae, 100g of Eclipta prostrata, 670g of sucrose, and 30g of dextrin.

[0028] Compared with the prior art, the beneficial effect of the present invention lies in that the method of the present invention adjusts the angle between the cutting knives in the granulator according to the extension rate of the granulation time of the wet granules. Due to the aging and damage of the insulation skin of the motor winding in the granulator, a short circuit may be caused, resulting in a decrease in the output power of the motor, and the inability to drive the cutting knives to reach a normal rotation speed, thereby causing uneven particle formation. By increasing the angle between the cutting knives in the granulator, a larger material area can be covered, so that the material can be cut in a wider range, reducing the possibility of material accumulation and adhesion, and helping to further chop large particle materials, thereby improving the uniformity of the particles. The stirring mode of the dry particles is adjusted according to the density of the Yangxue Anshen granules per unit volume. Due to the wear of the barrel wall in the mixer, the flow state of the material near the barrel wall may change. Changes may occur, resulting in material accumulation or insufficient mixing. By changing the stirring method of the dry particles, the materials can be subjected to shear and thrust in different directions. This change in direction helps to break the relatively static area formed near the cylinder wall, so that the materials originally accumulated near the cylinder wall can re-participate in the overall mixing process, thereby improving the uniformity of mixing. The drying batch size of the wet particles is adjusted according to the maximum temperature difference in the oven. Due to partial damage to the heating tube in the oven, uneven heating occurs, causing some areas of the material to be over-dried and some areas to be under-dried. By reducing the drying batch size of the wet particles, the limited heat can be distributed relatively more evenly in the material, reducing the possibility of over-drying and under-drying in some areas due to uneven heating, thereby improving the preparation stability of the Yangxue Anshen Granules.

[0029] Furthermore, the method of the present invention adjusts the angle between the cutting knives in the granulator by setting a preset first extension rate and a preset second extension rate. Due to the aging and damage of the insulation skin of the motor winding in the granulator, a short circuit may be caused, resulting in a decrease in the output power of the motor, and the inability to drive the cutting knife to reach a normal speed, thereby causing uneven particle formation. By increasing the angle between the cutting knives in the granulator, a larger material area can be covered, so that the material can be cut in a wider range, reducing the possibility of material accumulation and adhesion, and helping to further chop large particles, thereby improving the uniformity of the particles, and further improving the preparation stability of the blood-nourishing and calming granules.

[0030] Furthermore, the method of the present invention adjusts the stirring mode of the dry particles by setting a preset first density and a preset second density. Since the wear of the barrel wall in the mixer may cause the flow state of the material near the barrel wall to change, material accumulation or insufficient mixing may occur. By changing the stirring mode of the dry particles, the material can be subjected to shear force and thrust in different directions. This directional change helps to break the relatively static area formed near the barrel wall, so that the material originally accumulated near the barrel wall can re-participate in the overall mixing process, thereby improving the uniformity of the mixing and further improving the preparation stability of the Yangxue Anshen Granules.

[0031] Furthermore, the method of the present invention adjusts the drying batch size of the wet granules by setting a preset difference amount. Since the heating tube in the oven is partially damaged, the heating is uneven, causing some areas of the material to be over-dried and some areas to be under-dried. By reducing the drying batch size of the wet granules, the limited heat can be distributed relatively more evenly in the material, reducing the possibility of over-drying some areas and under-drying some areas due to uneven heating, and further improving the preparation stability of the Yangxue Anshen Granules. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 The overall flow chart of the preparation method of Yangxue Anshen Granules according to an embodiment of the present invention;

[0033] Figure 2 A logic flow chart of a process for adjusting the angle between cutting blades in a granulator in a method for preparing Yangxue Anshen Granules according to an embodiment of the present invention;

[0034] Figure 3 A logical flow chart of the process of adjusting the stirring mode of dry particles in the method for preparing Yangxue Anshen granules according to an embodiment of the present invention;

[0035] Figure 4 The present invention is a logical flow chart of the process of adjusting the drying batch size of wet granules in the method for preparing Yangxue Anshen granules according to an embodiment of the present invention. DETAILED DESCRIPTION

[0036] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0037] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0038] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0039] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0040] See also Figure 1 , Figure 2 , Figure 3 as well as Figure 4 As shown, they are respectively an overall flow chart of the Yangxue Anshen Granules and the preparation method thereof according to the embodiment of the present invention, a logic flow chart of the process of adjusting the angle between the cutting blades in the granulator, a logic flow chart of the process of adjusting the stirring mode of the dry granules, and a logic flow chart of the process of adjusting the dry batch size of the wet granules. A preparation method of Yangxue Anshen Granules according to the present invention comprises:

[0041] Step S1, soaking, boiling and filtering the first type of raw materials in sequence to output a first type of medicinal liquid and medicinal residues, adding the second type of raw materials to the medicinal residues and boiling them twice and then filtering to output a second type of medicinal liquid, combining and concentrating the first type of medicinal liquid and the second type of medicinal liquid to output a thick paste;

[0042] Step S2, adding sucrose and dextrin to the thick paste to output a soft material, granulating the soft material using a granulator to output wet granules, drying the wet granules using an oven to output dry granules, and mixing the selected dry granules using a mixing chamber to output Yangxue Anshen granules;

[0043] Step S3, obtaining the granulation time of the wet granules;

[0044] Step S4, determining the preparation stability of Yangxue Anshen Granules based on the extension rate of the granulation time of the wet granules;

[0045] Step S5, if the preparation stability does not meet the requirements, adjusting the angle between the cutting blades in the granulator, or determining the mixing effectiveness of the Yangxue Anshen Granules based on the density of the Yangxue Anshen Granules per unit volume;

[0046] Step S6, if the mixing effectiveness does not meet the requirements, the stirring method of the dry particles is adjusted, or the drying batch size of the wet particles is adjusted based on the maximum temperature difference in the oven.

[0047] Specifically, one type of raw materials includes Polygonum multiflorum, Millettia reticulata, and Albizzia julibrissin bark.

[0048] Specifically, one type of liquid medicine includes alkaloids, flavonoids, and polysaccharides.

[0049] Specifically, the drug residue includes cellulose, macromolecules, and fat.

[0050] Specifically, the second category of raw materials include Rehmannia root, Rehmannia glutinosa, Agrimonia sinensis, and Eclipta prostrata.

[0051] Specifically, the second type of liquid medicine includes iridoid glycosides, flavonoids, and saponins.

[0052] Specifically, the thick paste includes alkaloids, flavonoids, and glycosides.

[0053] Specifically, soft materials include alkaloids, sucrose, and dextrin.

[0054] Specifically, the process of soaking and boiling a type of raw materials in sequence is as follows: soak a type of raw materials in water for 2 hours, and then boil them for 1.5 hours.

[0055] Specifically, the process of adding the second type of raw materials to the medicinal residue and decocting twice is as follows: after adding the second type of raw materials to the medicinal residue, decocting for 1 hour for the first time and decocting for 1.5 hours for the second time.

[0056] Specifically, the process of combining and concentrating the first and second drug liquids to output a thick paste is as follows: combining the first and second drug liquids and letting them stand, taking the supernatant and concentrating it under reduced pressure to a thick paste with a relative density of 1.36 to 1.40 (50° C.).

[0057] In practice, the method of the present invention adjusts the angle between the cutting knives in the granulator according to the extension rate of the granulation time of the wet granules. Due to the aging and damage of the insulation skin of the motor winding in the granulator, a short circuit may be caused, resulting in a decrease in the output power of the motor, and the inability to drive the cutting knives to reach a normal speed, resulting in uneven particle formation. By increasing the angle between the cutting knives in the granulator, a larger material area can be covered, so that the material can be cut in a wider range, reducing the possibility of material accumulation and adhesion, and helping to further chop large particles, thereby improving the uniformity of the particles. The stirring mode of the dry particles is adjusted according to the density of the Yangxue Anshen granules per unit volume. Due to the wear of the barrel wall in the mixer, the flow state of the material near the barrel wall may change, resulting in material accumulation. In the case of insufficient accumulation or mixing, by changing the stirring method of the dry particles, the material can be subjected to shear force and thrust in different directions. This change in direction helps to break the relatively static area formed near the cylinder wall, so that the material originally accumulated near the cylinder wall can re-participate in the overall mixing process, thereby improving the uniformity of mixing. The drying batch size of the wet particles is adjusted according to the maximum temperature difference in the oven. Due to partial damage to the heating tube in the oven, uneven heating occurs, causing some areas of the material to be over-dried and some areas to be under-dried. By reducing the drying batch size of the wet particles, the limited heat can be distributed relatively more evenly in the material, reducing the possibility of over-drying and under-drying in some areas due to uneven heating, thereby improving the preparation stability of the Yangxue Anshen Granules.

[0058] Specifically, determining the preparation stability of the Yangxue Anshen Granules includes:

[0059] comparing the extension rate of the granulation time of the wet granules with a preset first extension rate;

[0060] If the extension rate of the granulation time of the wet granules is greater than the preset first extension rate, it is determined that the preparation stability of the Yangxue Anshen Granules does not meet the requirements.

[0061] Specifically, the mixed effectiveness of the Yangxue Anshen Granule is determined, including:

[0062] comparing the extension rate of the granulation time of the wet granules with the preset first extension rate and the preset second extension rate respectively;

[0063] If the extension rate of the granulation time of the wet granules is greater than the preset first extension rate and less than or equal to the preset second extension rate, it is preliminarily determined that the mixing effectiveness of the Yangxue Anshen Granules does not meet the requirements, and whether the mixing effectiveness of the Yangxue Anshen Granules meets the requirements is determined based on the density of the Yangxue Anshen Granules in unit volume.

[0064] It can be understood that the three intervals divided by the preset first extension rate and the preset second extension rate correspond to three situations respectively:

[0065] The first interval is that the extension rate of the granulation time of the wet granules is less than or equal to the preset first extension rate, and the corresponding situation is: it is determined that the preparation stability of the Yangxue Anshen Granules meets the requirements;

[0066] The second interval is when the extension rate of the granulation time of the wet granules is greater than the preset first extension rate and less than or equal to the preset second extension rate, and the corresponding situation is: due to the wear of the barrel wall in the mixer, the flow state of the material near the barrel wall may change, resulting in material accumulation or insufficient mixing;

[0067] The third interval is when the extension rate of the granulation time of the wet granules is greater than the preset second extension rate. The corresponding situation is: due to the aging and damage of the insulation skin of the motor winding in the granulator, a short circuit may be caused, resulting in a decrease in the output power of the motor, and the cutting knife cannot be driven to reach a normal speed, resulting in uneven granulation.

[0068] In practice, the preset first extension rate is generally selected in the range of [13%, 17%], and the preset second extension rate is generally selected in the range of [18%, 22%].

[0069] Preferably, the preferred embodiment of the preset first extension rate is 15%, and the preferred embodiment of the preset second extension rate is 20%.

[0070] Specifically, the extension rate of the granulation time of the wet granules is the ratio of the difference between the granulation time of the actual wet granules and the granulation time of the standard wet granules to the granulation time of the standard wet granules.

[0071] In implementation, the method of the present invention determines the preparation stability of Yangxue Anshen Granules by setting a preset first extension rate and a preset second extension rate, thereby reducing the impact of decreased preparation accuracy of Yangxue Anshen Granules due to inaccurate determination of the preparation stability of Yangxue Anshen Granules, and further improving the preparation stability of Yangxue Anshen Granules.

[0072] Specifically, adjusting the angle between the cutting knives in the granulator comprises:

[0073] comparing the extension rate of the granulation time of the wet granules with the preset second extension rate;

[0074] If the extension rate of the granulation time of the wet granules is greater than the preset second extension rate, the angle between the cutting knives in the granulator is increased.

[0075] Specifically, the increase range of the angle between the cutting knives in the granulator is determined by the difference between the extension rate of the granulation time of the wet granules and a preset second extension rate.

[0076] Specifically, when the difference between the extension rate of the granulation time of the wet granules and the preset second extension rate is within 5%, the angle between the cutting knives in the granulator is increased to 1.1 times of the original; when the difference between the extension rate of the granulation time of the wet granules and the preset second extension rate exceeds 5%, on the basis of being increased to 1.1 times of the original, the angle between the cutting knives in the granulator is increased by 3° for every 2% exceeding the extension rate. For example, the difference between the extension rate of the granulation time of the wet granules and the preset second extension rate is 9%, the angle between the cutting knives in the current granulator is 60°, and the angle between the cutting knives in the granulator after the increase is 60×1.1+3×2=72°.

[0077] In implementation, the method of the present invention adjusts the angle between the cutting knives in the granulator by setting a preset first extension rate and a preset second extension rate. Due to the aging and damage of the insulation skin of the motor winding in the granulator, a short circuit may be caused, resulting in a decrease in the output power of the motor, and the inability to drive the cutting knife to reach a normal speed, thereby causing uneven particle formation. By increasing the angle between the cutting knives in the granulator, a larger material area can be covered, so that the material can be cut in a wider range, reducing the possibility of material accumulation and adhesion, and helping to further chop large particles, thereby improving the uniformity of the particles, and further improving the preparation stability of the blood-nourishing and calming granules.

[0078] Specifically, the stirring method of the dry particles is adjusted, including:

[0079] The density of the Yangxue Anshen granules in the unit volume is compared with the preset first density and the preset second density respectively;

[0080] If the density of the Yangxue Anshen Granules in the unit volume is less than or equal to the preset second density, it is determined that the mixing effectiveness of the Yangxue Anshen Granules does not meet the requirements;

[0081] If the density of the Yangxue Anshen granules in the unit volume is greater than the preset first density and less than or equal to the preset second density, adjusting the stirring mode of the dry granules;

[0082] If the density of the Yangxue Anshen Granules in the unit volume is greater than the preset first density, it is preliminarily determined that the drying effectiveness does not meet the requirements, and whether the drying effectiveness meets the requirements is determined based on the maximum temperature difference in the oven.

[0083] It can be understood that the three intervals divided by the preset first density and the preset second density correspond to three situations respectively:

[0084] The first interval is when the density of Yangxue Anshen granules per unit volume is greater than the preset first density. The corresponding situation is that due to the partial damage of the heating tube in the oven, the heating is uneven, causing some areas of the material to be over-dried and some areas to be under-dried.

[0085] The second interval is when the density of Yangxue Anshen Granules per unit volume is greater than the preset first density and less than or equal to the preset second density. The corresponding situation is that due to the wear of the cylinder wall in the mixer, the flow state of the material near the cylinder wall may change, resulting in material accumulation or insufficient mixing.

[0086] The third interval is that the density of the Yangxue Anshen Granules in unit volume is greater than the preset second density, and the corresponding situation is: determining that the mixing effectiveness of the Yangxue Anshen Granules meets the requirements.

[0087] In practice, the preset first density is generally selected in the range of [0.4 g / cm 3 , 0.6g / cm 3 ], the preset second density is generally selected in the range of [0.7g / cm 3 , 0.9g / cm 3 ].

[0088] Preferably, the preferred embodiment of the preset first density is 0.5 g / cm 3 The preferred embodiment of the preset second density is 0.8 g / cm 3 .

[0089] In implementation, the method of the present invention determines the mixing effectiveness of the Yangxue Anshen Granules by setting a preset first density and a preset second density, thereby reducing the impact of the decreased preparation stability of the Yangxue Anshen Granules due to inaccurate determination of the mixing effectiveness of the Yangxue Anshen Granules, and further improving the preparation stability of the Yangxue Anshen Granules.

[0090] Specifically, the stirring mode of the dry particles is adjusted from continuous stirring to forward and reverse alternating stirring.

[0091] In implementation, the method of the present invention adjusts the stirring mode of the dry particles by setting a preset first density and a preset second density. The wear of the barrel wall in the mixer may cause the flow state of the material near the barrel wall to change, resulting in material accumulation or insufficient mixing. By changing the stirring mode of the dry particles, the material can be subjected to shear force and thrust in different directions. This directional change helps to break the relatively static area formed near the barrel wall, so that the material originally accumulated near the barrel wall can re-participate in the overall mixing process, thereby improving the uniformity of the mixing and further improving the preparation stability of the blood-nourishing and calming granules.

[0092] Specifically, the drying batch size of the wet granules is adjusted, including:

[0093] comparing the maximum temperature difference in the oven with a preset difference;

[0094] If the maximum temperature difference in the oven is greater than the preset difference, it is determined that the drying effectiveness does not meet the requirements, and the drying batch size of the wet particles is reduced.

[0095] It can be understood that the two intervals divided by the preset difference amount correspond to two situations:

[0096] The first interval is that the maximum temperature difference in the oven is less than or equal to the preset difference, and the corresponding situation is: it is determined that the drying effectiveness meets the requirements;

[0097] The second interval is when the maximum temperature difference in the oven is greater than the preset difference. The corresponding situation is: due to partial damage to the heating tube in the oven, the heating is uneven, causing some areas of the material to be over-dried and some areas to be under-dried.

[0098] In practice, the preset difference amount is generally selected in the range of [4°C, 6°C].

[0099] Preferably, a preferred embodiment of the preset difference amount is 5°C.

[0100] Specifically, the maximum temperature difference in the oven is the difference between the highest temperature in the oven and the lowest temperature in the oven.

[0101] In implementation, the method of the present invention determines the drying effectiveness by setting a preset difference amount, thereby reducing the impact of the decreased preparation stability of the Yangxue Anshen Granules due to inaccurate determination of the drying effectiveness, and further improving the preparation stability of the Yangxue Anshen Granules.

[0102] Specifically, the reduction range of the drying batch size of the wet granules is determined by the difference between the maximum temperature difference in the oven and a preset temperature difference.

[0103] Specifically, when the difference between the maximum temperature difference in the oven and the preset difference is within 2°C, the drying batch size of the wet granules is reduced to 0.9 times the original size; when the difference between the maximum temperature difference in the oven and the preset difference is greater than 2°C, on the basis of being reduced to 0.9 times the original size, the drying batch size of the wet granules is reduced by 1kg for every 1°C greater than the original size. For example, the difference between the maximum temperature difference in the oven and the preset difference is 4°C, the current drying batch size of the wet granules is 20kg, and the reduced drying batch size of the wet granules is 20×0.9-1×2=16kg.

[0104] In implementation, the method of the present invention adjusts the drying batch size of wet granules by setting a preset difference amount. Since the heating tube in the oven is partially damaged, the heating is uneven, causing some areas of the material to be over-dried and some areas to be under-dried. By reducing the drying batch size of the wet granules, the limited heat can be distributed relatively more evenly in the material, reducing the possibility of over-drying some areas and under-drying some areas due to uneven heating, and further improving the preparation stability of the Yangxue Anshen Granules.

[0105] A blood-nourishing and mind-calming granule comprises the following components and contents: 100g of Polygonum multiflorum, 100g of Millettia spatholobi, 100g of Albizzia julibrissin, 100g of Rehmannia glutinosa, 100g of Rehmannia glutinosa, 167g of Agrimoniae, 100g of Ecliptae, 670g of sucrose and 30g of dextrin.

[0106] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

Claims

1. A method for preparing blood-nourishing and tranquilizing granules, characterized in that: include: The first type of raw materials are sequentially soaked, boiled and filtered to output the first type of medicinal liquid and medicinal residues, the second type of raw materials are added to the medicinal residues and boiled twice and then filtered to output the second type of medicinal liquid, and the first type of medicinal liquid and the second type of medicinal liquid are combined and concentrated to output a thick paste; Adding sucrose and dextrin to the thick paste to output a soft material, granulating the soft material with a granulator to output wet granules, drying the wet granules with an oven to output dry granules, and mixing the selected dry granules with a mixing chamber to output Yangxue Anshen granules; Get the granulation time of wet granules; The preparation stability of Yangxue Anshen Granules was determined based on the extension rate of granulation time of wet granules; If the preparation stability does not meet the requirements, the angle between the cutting knives in the granulator is adjusted, or the mixing effectiveness of the Yangxue Anshen Granules is determined based on the density of the Yangxue Anshen Granules per unit volume; If the mixing effectiveness is not satisfactory, the agitation of the dry granules is adjusted, or the drying batch size of the wet granules is adjusted based on the maximum temperature difference in the oven.

2. The method for preparing the Yangxue Anshen granules according to claim 1, characterized in that: Determining the preparation stability of the Yangxue Anshen granules includes: comparing the extension rate of the granulation time of the wet granules with a preset first extension rate; If the extension rate of the granulation time of the wet granules is greater than the preset first extension rate, it is determined that the preparation stability of the Yangxue Anshen Granules does not meet the requirements.

3. The method for preparing the Yangxue Anshen granules according to claim 2, characterized in that: Determine the mixed effectiveness of the Yangxue Anshen granules, including: comparing the extension rate of the granulation time of the wet granules with the preset first extension rate and the preset second extension rate respectively; If the extension rate of the granulation time of the wet granules is greater than the preset first extension rate and less than or equal to the preset second extension rate, it is preliminarily determined that the mixing effectiveness of the Yangxue Anshen Granules does not meet the requirements, and whether the mixing effectiveness of the Yangxue Anshen Granules meets the requirements is determined based on the density of the Yangxue Anshen Granules in unit volume.

4. The method for preparing the Yangxue Anshen granules according to claim 3, characterized in that: The angle between the cutting blades in the granulator is adjusted, comprising: comparing the extension rate of the granulation time of the wet granules with the preset second extension rate; If the extension rate of the granulation time of the wet granules is greater than the preset second extension rate, the angle between the cutting knives in the granulator is increased.

5. The method for preparing the Yangxue Anshen granules according to claim 4, characterized in that: The increase range of the angle between the cutting knives in the granulator is determined by the difference between the extension rate of the granulation time of the wet granules and a preset second extension rate.

6. The method for preparing the Yangxue Anshen granules according to claim 5, characterized in that: The stirring mode of the dry particles is adjusted, including: The density of the Yangxue Anshen granules in the unit volume is compared with the preset first density and the preset second density respectively; If the density of the Yangxue Anshen Granules in the unit volume is less than or equal to the preset second density, it is determined that the mixing effectiveness of the Yangxue Anshen Granules does not meet the requirements; If the density of the Yangxue Anshen granules in the unit volume is greater than the preset first density and less than or equal to the preset second density, adjusting the stirring mode of the dry granules; If the density of the Yangxue Anshen Granules in the unit volume is greater than the preset first density, it is preliminarily determined that the drying effectiveness does not meet the requirements, and whether the drying effectiveness meets the requirements is determined based on the maximum temperature difference in the oven.

7. The method for preparing the Yangxue Anshen granules according to claim 6, characterized in that: The stirring mode of the dry particles is adjusted from continuous stirring to forward and reverse alternating stirring.

8. The method for preparing the Yangxue Anshen granules according to claim 7, characterized in that: The drying batch size of the wet granules is adjusted, comprising: comparing the maximum temperature difference in the oven with a preset difference; If the maximum temperature difference in the oven is greater than the preset difference, it is determined that the drying effectiveness does not meet the requirements, and the drying batch size of the wet particles is reduced.

9. The method for preparing the Yangxue Anshen granules according to claim 8, characterized in that: The reduction range of the drying batch size of the wet granules is determined by the difference between the maximum temperature difference in the oven and the preset temperature difference.

10. A Yangxue Anshen granule prepared by the preparation method of Yangxue Anshen granule according to any one of claims 1 to 9, characterized in that: Its components include: Polygonum multiflorum, Millettia spatholobi, Albizzia julibrissin, Rehmannia root, Rehmannia glutinosa, Agrimoniae, Eclipta prostrata, sucrose and dextrin.

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