Traditional Chinese medicine formula for treating peripheral facial paralysis

Abstract

The invention discloses a traditional Chinese medicine formula for treating peripheral facial paralysis. The traditional Chinese medicine formula comprises the following raw materials by weight: 12-20 g of cassia twig, 5-20 g of white peony root, 3-13 g of honey-fried licorice root, 10-20 g of jujube, 10-30 g of ginger, 5-15 g of root of kudzu vine, 5-15 g of dahurian angelica root, 3-12 g of cimicifuga foetida, 5-20 g of caulis spatholobi and 2-10 g of platycodon grandiflorum. The traditional Chinese medicine composition can be used for treating facial nerve ischemia and hypoxia caused by peripheral facial paralysis and nerve paralysis caused by facial nerve compression, and recovering nerve functions. The traditional Chinese medicine disclosed by the invention is simple and easy to obtain, quick in effect taking, small in side effect, low in cost and short in treatment course, and panic and pain of patients are effectively relieved to a great extent.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine prescription for treating peripheral facial nerve paralysis and a preparation method of the traditional Chinese medicine composition. Background Art

[0002] Facial paralysis is a common disease in acupuncture clinics. Measures should be taken as soon as possible. Basic treatment includes keeping warm, applying hot compresses near the stylomastoid foramen, and coordinating with shortwave therapy to improve local blood circulation, promote the elimination of local edema and inflammation, and relieve the compression of the facial nerve. At the same time, pay attention to protecting the exposed cornea on the diseased side to avoid corneal infection. In the later stage of facial neuritis, pay attention to preventing the paralyzed muscles from being excessively pulled by the muscles on the healthy side, pay attention to the rehabilitation of local muscles, practice the voluntary movements of the facial muscles, and promote the rehabilitation of nerve function.

[0003] Facial paralysis caused by facial neuritis is extremely important for the recovery of facial neuritis. In the early stage, the treatment is mainly to remove evil according to the syndrome differentiation, such as removing wind, dispersing cold, unblocking meridians, and removing phlegm. In the later stage, attention should be paid to nourishing the positive energy, replenishing qi and nourishing blood. When qi and blood are vigorous, muscles can be nourished, and evil can be effectively resisted, which promotes recovery.

[0004] Modern research on facial neuritis is increasingly leaning towards viral infection. Therefore, patients with facial neuritis with a clear history of viral infection can choose Chinese medicines with antiviral effects such as isatis indigotica, isatis root, coptis chinensis, etc. based on the pharmacology of traditional Chinese medicine in the early stages of the disease to improve the efficacy.

[0005] When the patient has obvious tenderness behind the ear and cannot sleep at night, the treatment is treated by the combination of Chinese medicine and acupuncture. The main purpose of acupuncture is to prevent pain behind the ear. The acupoint method can be used. For example, the Waiguan acupoint can be used to drain excess and replenish deficiency.

[0006] In short, the difficulty in treating common diseases lies in clinical certification, which is mainly about grasping individual differences, starting early, and focusing on individualized treatment, which will reduce the occurrence of sequelae.

[0007] The above is the current diagnostic and treatment ideas and treatment plans of Chinese and Western medicine. Western medicine's hormone shock therapy and symptomatic treatment cycles are long, symptoms are slow to relieve, and are prone to leave sequelae, so they are often treated together with Chinese medicine. Chinese medicine mainly uses acupuncture and moxibustion, with prescriptions as an auxiliary, which is quick to take effect, but complete recovery is slow. Summary of the invention

[0008] In order to solve the problem that the existing treatment methods for peripheral facial nerve paralysis have large side effects, Western medicine hormone shock therapy is difficult for patients to accept, and other symptomatic treatments are not effective; Chinese medicine acupuncture makes many patients feel fearful, and traditional Chinese medicine decoctions are slow to take effect; it takes about 7 days for the combination of Chinese and Western medicine to achieve obvious effects, and about 30 days for complete recovery. The Chinese medicine composition provided by the present invention generally shows obvious effects in 3 days for patients, and can be cured in 7 to 10 days, and no recurrence is found in follow-up.

[0009] In order to solve the above technical problems, the present invention provides a traditional Chinese medicine formula for treating peripheral facial nerve paralysis, comprising the following raw materials by weight: 12-20 grams of cinnamon twig, 5-20 grams of white peony root, 3-13 grams of roasted licorice root, 10-20 grams of jujube, 10-30 grams of ginger, 5-15 grams of kudzu root, 5-15 grams of angelica root, 3-12 grams of cimicifuga, 5-20 grams of Millettia reticulata, and 2-10 grams of Platycodon grandiflorum.

[0010] As a preferred embodiment of the above technical solution, the Chinese medicine formula for treating peripheral facial nerve paralysis provided by the present invention further includes part or all of the following technical features:

[0011] As an improvement of the above technical solution, the following raw materials are included in grams: 20 grams of cinnamon twig, 20 grams of white peony root, 13 grams of roasted licorice root, 20 grams of jujube, 30 grams of ginger, 15 grams of kudzu root, 15 grams of angelica dahurica, 12 grams of cimicifuga, 20 grams of Millettia reticulata, and 10 grams of Platycodon grandiflorum (high-dose group).

[0012] As an improvement of the above technical scheme, the following raw materials are included in grams: 5 grams of cinnamon twig, 5 grams of white peony root, 3 grams of roasted licorice root, 10 grams of jujube, 10 grams of ginger, 5 grams of Pueraria root, 5 grams of Angelica dahurica, 3 grams of Cimicifuga heracleifolia, 5 grams of Millettia reticulata, and 2 grams of Platycodon grandiflorum (low-dose group).

[0013] As an improvement of the above technical solution, the following raw materials are included in grams: 10 grams of cinnamon twig, 10 grams of white peony root, 8 grams of roasted licorice root, 15 grams of jujube, 20 grams of ginger, 10 grams of Pueraria root, 10 grams of Angelica dahurica, 8 grams of Cimicifuga heracleifolia, 15 grams of Millettia reticulata, and 6 grams of Platycodon grandiflorum (medium dose group).

[0014] The present invention also provides a method for preparing a Chinese medicine composition for treating peripheral facial paralysis, which is characterized in that: adding water to the raw material medicine described in any of the above Chinese medicine prescriptions for treating peripheral facial nerve paralysis, soaking at 18-25°C for 15-25 minutes, then boiling over high heat, then turning to low heat, decocting for 20-30 minutes, filtering to obtain a filtrate, and setting aside; adding water to the filter residue, boiling over high heat, then turning to low heat, decocting for 10-15 minutes, filtering, discarding the filter residue, obtaining a filtrate, combining the two filtrates, and concentrating to obtain the product.

[0015] As a preferred embodiment of the above technical solution, the method for preparing a Chinese medicine composition for treating peripheral facial paralysis provided by the present invention further includes part or all of the following technical features:

[0016] As an improvement of the above technical solution, the amount of water added in the first decoction is 6 to 10 times the total drug mass, and the amount of water added in the second decoction is 3 to 4 times the total drug mass, concentrated to one third of the two water additions.

[0017] Use of the composition as described in any one of the above items in the preparation of a medicament for treating peripheral facial paralysis.

[0018] A medicine for treating peripheral facial paralysis, comprising any of the above-mentioned compositions or the composition prepared by the preparation method, and medically acceptable adjuvants.

[0019] As an improvement of the above technical solution, the dosage form of the drug includes traditional Chinese medicine preparations, granules, pills, tablets, oral liquids, capsules, powders and dusts.

[0020] As an improvement of the above technical solution, the preparation method of the Chinese medicine preparation comprises the following steps:

[0021] S1: Prepare medicinal materials: weigh the medicinal materials according to the Chinese medicine formula by weight, weigh 12-20 parts of cinnamon twig, 5-20 parts of white peony root, 3-13 parts of roasted licorice root, 10-20 parts of jujube, 10-30 parts of ginger, 5-15 parts of kudzu root, 5-15 parts of angelica, 3-12 parts of cimicifuga, 5-20 parts of millettia reticulata, 2-10 parts of platycodon, wash them separately, cut them into small pieces of 0.5-5 cm, and dry them in a cool place;

[0022] S2: Soaking in water: Add water to the medicinal materials prepared in step S1 until the amount of water is 6 to 10 times the total weight of the medicinal materials, and soak at 18 to 25°C for 15 to 25 minutes;

[0023] S3: primary water extraction: soak the mixture in the water of step S2, heat it to boiling, extract it by heat preservation, filter it, and concentrate the filtrate to obtain concentrated solution A;

[0024] S4: Secondary water extraction: add water to the filter residue of step S3 to 3 to 4 times the total amount of the drug, heat to boiling, extract by heat preservation, filter, and concentrate the filtrate to obtain concentrated solution B;

[0025] S5: Preparation: After the concentrate A and the concentrate B are mixed, auxiliary materials are added, and the mixture is packaged to prepare a Chinese medicine preparation.

[0026] As an improvement of the above technical solution, step S5 can also be: after mixing the concentrate A and the concentrate B, add the oral liquid preparation excipients to the mixed concentrate to make an oral liquid preparation; or add the granule preparation excipients to the mixed concentrate to make a granule preparation; or add tablet excipients to the mixed concentrate, granulate, add a lubricant after granulation, and press to make tablets.

[0027] This Chinese medicine formula is based on Guizhi Decoction as the base, and is made up of Guizhi Decoction, Guizhi, white peony root, ginger, jujube, and roasted licorice. Article 16 of Treatise on Febrile Diseases: If a patient with a solar disease has been sweating for three days, but vomiting, diarrhea, or warm needles still do not relieve the disease, this is a bad disease, and Guizhi is not suitable for it. Observe the pulse and symptoms to know what is wrong and treat it accordingly. Guizhi is originally used to relieve muscles. If the patient has a floating and tight pulse, fever, and no sweating, it should not be used. Always remember this and don't make mistakes. External evil qi penetrates the surface of the body and reaches the muscle level. Using Guizhi Decoction to treat it is the original intention of Guizhi to relieve muscles. Peripheral facial nerve paralysis manifests as functional disorders of facial muscles.

[0028] The syndrome of Guizhi Decoction is caused by wind evil injuring the skin surface, loose pores, Wei Qi leaking out, Ying Yin not being able to stay inside, and disharmony between the lung and stomach. The treatment is mainly to relieve muscles and release the exterior, and to harmonize Ying and Wei. This prescription is characterized by superficial deficiency, loose pores, and strong Wei and weak Ying, so Guizhi is used as the main medicine to relieve muscles and release the exterior, dissipate the wind evil caused by the external infection, and Peony is used as the minister to nourish Yin and restrain Ying. Guizhi and Peony are combined, one to treat strong Wei and the other to treat weak Ying, and together they can harmonize Ying and Wei, and they are mutually dependent. Ginger is pungent and warm, which can not only help Guizhi to relieve muscles, but also warm the stomach and stop vomiting. Jujube is sweet and flat, which can not only replenish Qi and nourish the middle, but also nourish the spleen and produce body fluid. Ginger and jujube are combined to raise the Qi of the spleen and stomach and harmonize Ying and Wei, so they are both adjuvants. There are two uses of roasted licorice: one is as an adjuvant, to replenish Qi and harmonize the middle, combined with Guizhi as a minister to relieve muscles, and combined with Peony to replenish Yin; the other is to harmonize the various medicines. Therefore, although this prescription contains only five herbs, the combination is rigorous and the dispersing herbs have tonifying properties. Just as Ke Qin praised Guizhi Decoction in the Appendix to Treatise on Febrile Diseases, "It is the best among all the prescriptions of Zhang Zhongjing, and it is the general prescription for nourishing yin and yang, harmonizing the Ying and Wei, and relieving muscles and inducing sweating."

[0029] The characteristics of the compatibility are that cinnamon twig is pungent and warm, and pungent can dispel evil, and warm from yang to support defense, so it is the main drug. Peony is sour and cold, and sour can restrain sweat, and cold goes to yin and benefits the camp. Cinnamon twig is the main drug and peony is the subordinate, which means that it contains the meaning of restraining sweat in dispersing; peony is the subordinate, and cinnamon twig has the way of slightly sweating in consolidating the exterior. The pungent ginger assists cinnamon twig to relieve the skin surface; the sweet jujube assists peony to harmonize the camp. Licorice is sweet and flat, and has the ability to calm the inside and repel the outside. It is used to harmonize the middle qi, that is, to harmonize the exterior and interior, and to harmonize all the drugs. With the mutual support of cinnamon and peony, and the mutual benefit of ginger and jujube, the harmonization of yang exterior and yin interior by licorice, qi, defense, blood and camp are parallel and not contradictory, which is the harmony of hardness and softness.

[0030] Characteristics of Guizhi Decoction: This prescription treats exogenous solar stroke (a type of cold), harmonizes the spleen and stomach, and balances yin and yang. Modern pharmacological research shows that Guizhi Decoction can enhance immunity, promote gastrointestinal function, and significantly promote muscle blood circulation. Modern pharmacological research has well explained the muscle-relieving mechanism of Guizhi Decoction.

[0031] Peripheral facial nerve paralysis (facial paralysis) will inevitably lead to abnormal blood circulation of facial muscles (disharmony between Ying and Wei), which is the main cause of many muscle problems. Guizhi Decoction is a classic prescription for solving the disharmony between Ying and Wei in muscles. It can promote blood circulation in muscles and promote the body's own recovery. It does not directly target bacteria and viruses, but Guizhi Decoction targets muscles throughout the body. Using Guizhi Decoction alone to treat facial paralysis has poor targeting and no obvious effect. The traditional prescription for treating facial paralysis, Qianzhengsan, is composed of white aconite, white silkworm, and scorpion. White aconite and scorpion are both poisonous herbs and the effect is not good. Now, Qianzhengsan is used as the basic prescription and other Chinese herbal medicines for promoting blood circulation and removing blood stasis and dredging meridians are added to the prescription. The effect is poor and can only be used as an auxiliary means. I added Yangming meridian medicines Pueraria lobata, Angelica dahurica, and Cimicifuga heracleifolia to Guizhi Decoction, so that the medicinal effects of Guizhi Decoction are concentrated in the Yangming meridian muscles. I added Platycodon grandiflorum to lead the medicine upward, so that the medicinal effects are concentrated in the facial muscles, which has a certain targeted effect. I added Millettia reticulata to dredge the meridians, activate blood circulation, and replenish blood. The combined effects can quickly promote blood circulation in the facial muscles and quickly repair paralyzed facial muscles, thus achieving an effective prescription for the treatment of facial paralysis.

[0032] The raw materials of the invention are cheap and easily available, the preparation method is simple, the cost is low, the administration is easy, the effect is good, and the invention can be used to treat facial nerve ischemia and hypoxia caused by peripheral facial paralysis, as well as nerve paralysis caused by facial nerve compression, and restore nerve function. The invention is an innovation in drugs for treating peripheral facial paralysis.

[0033] The dosage and course of treatment of the Chinese medicine composition of the present invention can be selected according to the age of the patient and the severity of the disease. For acute patients who take the medicine in time, they generally recover more than half in three days and basically recover as before in one week without recurrence. Patients who have been treated with Western medicine for more than ten days generally need about ten days to recover; patients who have been treated with Western medicine for more than one month and have mild sequelae need about twenty days of treatment. The pain of the patients I have met has been alleviated, the economic expenditure has been reduced, and the course of the disease has been shortened.

[0034] The cassia twig described in the present invention is Lauraceae Dried young branches of the plant cinnamon. Spicy and hot. Floating, the yang among the yang. The thinner the qi, the cinnamon twig; the thicker the qi, the cinnamon bark. It enters the lungs, heart, Bladder Meridian. Induces sweating and relieves exterior symptoms, warms and dredges the meridians, and warms and assists Yang Qi. Cinnamon twigs have the effect of inducing sweating and dredges exterior symptoms, can dilate skin blood vessels, open body surface pores, and are helpful in relieving symptoms such as colds, rheumatism and pain. Cinnamon twigs have the effect of warming the meridians and dredges the meridians, can promote the circulation of Qi and blood in the human body, and have a certain effect on relieving symptoms such as pain and irregular menstruation caused by cold and blood stasis. Cinnamon twigs have the effect of assisting Yang and transforming Qi, can warm and replenish Yang Qi, promote Qi transformation, and have a certain effect on relieving symptoms such as chills, cold limbs, and sore waist and knees caused by Yang deficiency.

[0035] The white peony root described in the present invention is a Chinese medicine name. It is the dried root of the ranunculaceae plant peony. It tastes bitter, sour, and is slightly cold in nature. It enters the liver and spleen meridians. It nourishes blood and regulates menstruation, restrains yin and stops sweating, softens the liver and relieves pain, and suppresses liver yang. White peony root can promote the formation of red blood cells and blood circulation, thereby playing a role in blood tonification, helping to improve symptoms such as anemia and fatigue, and is especially effective for problems such as irregular menstruation, oligomenorrhea, and amenorrhea caused by blood deficiency in women. White peony root enters the liver meridian, can relieve symptoms such as chest and flank distension and pain caused by liver qi stagnation, and can treat symptoms such as chest and flank abdominal pain, limb cramps and pain caused by liver qi discomfort. At the same time, white peony root can also relieve muscle tension, has a certain relieving effect on spasm, and is commonly used to treat gastrocnemius spasm, gastrointestinal colic, etc. White peony root has the effect of astringing sores and promoting tissue regeneration, can promote the healing of wounds such as sores and ulcers, and is effective for treating symptoms such as sores and ulcers caused by yin deficiency and blood deficiency that are difficult to heal.

[0036] The cinnamon twig platycodon described in the present invention is the dried root of the platycodon grandiflorum plant of the Campanulaceae family. It is bitter and pungent in taste and has a neutral nature. It enters the lung meridian, clears the lungs, relieves sore throat, eliminates phlegm, and discharges pus, and can carry various medicines upward. The antibacterial and anti-inflammatory effects of platycodon grandiflorum have been widely studied. Studies have found that the triterpenoid saponins in platycodon grandiflorum can inhibit the growth of various bacteria and fungi and have a broad-spectrum antibacterial effect. In addition, the flavonoid compounds in platycodon grandiflorum have an anti-inflammatory effect, can inhibit the release of inflammatory mediators, and alleviate inflammatory reactions. Clinical studies have shown that platycodon grandiflorum can be used to treat respiratory infections and inflammatory diseases, such as bronchitis, pneumonia, etc.

[0037] The kudzu root described in the present invention is the dried root of the leguminous plant kudzu, commonly known as kudzu, which is sweet, spicy and cool. It enters the spleen, stomach and lung meridians, and has the functions of relieving muscles and fever, clearing rashes, promoting body fluid and quenching thirst, raising yang and stopping diarrhea, promoting blood circulation and activating collaterals, and detoxifying alcohol. Modern pharmacological effects, anti-inflammatory effect: the flavonoid components therein have the ability to inhibit the release of inflammatory mediators, can effectively reduce inflammatory reactions, and have significant effects on relieving the symptoms of various inflammatory diseases. Antioxidant effect: It contains rich flavonoids and flavonoid glycosides, which have strong antioxidant capacity, can scavenge free radicals, protect cells from oxidative damage, and delay aging. Hypolipidemic effect: the flavonoid components therein help to lower blood lipid levels, reduce the deposition of cholesterol in the blood vessel wall, thereby reducing the risk of atherosclerosis and maintaining cardiovascular health. Antihypertensive effect: the flavonoid components therein can dilate blood vessels, lower blood pressure, help improve hypertension symptoms, and reduce the occurrence of cardiovascular and cerebrovascular diseases.

[0038] The angelica dahurica described in the present invention is the dried root of the umbelliferae plant angelica dahurica or the angelica dahurica, which is pungent in taste, warm in nature, and enters the lung, spleen, and stomach meridians, and can dispel the cold, dispel wind and relieve pain, clear the nasal passages, dry dampness and stop leukorrhea, reduce swelling and discharge pus, and dispel wind and relieve itching. Modern pharmacological effects, analgesia, analgesia is to use the components such as isoimperatorin contained in angelica dahurica to inhibit nerve conduction, so as to achieve the purpose of relieving pain. Antipyretic, the drug has a certain antipyretic effect, because it can reduce the set point of the body temperature center, reduce the body's heat production, and then achieve the effect of cooling. Anti-inflammatory, the compounds in angelica dahurica can block the generation and release of inflammatory mediators, reduce tissue edema and erythema, and thus play an anti-inflammatory effect. Anticonvulsant Certain components in angelica dahurica can enhance the opening frequency of chloride ion channels mediated by gamma-aminobutyric acid type A receptor, play a role in stabilizing the membrane potential of nerve cells, and therefore have a certain anticonvulsant effect. Expectorant, angelica dahurica promotes the discharge of respiratory secretions to dilute sputum, making it easy to cough up, thereby achieving the effect of expectorant.

[0039] The Cimicifuga described in the present invention is the dried rhizome of Cimicifuga datrifolia, Cimicifuga xing'anensis or Cimicifuga datrifolia of the Ranunculaceae family. It is pungent, sweet, slightly cold, and enters the lung, spleen, large intestine, and stomach meridians. It can release rashes, clear away heat and detoxify, raise yang and lift sunken qi, treat epidemic diseases, headache, cold and heat, sore throat, mouth sores, macules that do not clear up; sinking of middle qi, chronic diarrhea and dysentery, prolapse of the anus, metrorrhagia, leukorrhea, and prolapse of the uterus in women; carbuncle, swelling, and sore. Modern pharmacology confirms that it has the effects of antipyretic and analgesic; anti-inflammatory; anticonvulsant; increasing white blood cells and improving immunity; inhibiting intestinal spasm; slowing down the heart rate; regulating blood pressure, etc.

[0040] The Millettia spatholobi described in the present invention is the dried vine stem of the leguminous plant Beans, which is bitter, sweet, warm, and enters the liver and kidney meridians, and can promote blood circulation and replenish blood, regulate menstruation and relieve pain, and relax muscles and activate collaterals. Modern pharmacology, anti-inflammatory effect: Some components in Millettia spatholobi have anti-inflammatory effects, such as triterpenoid compounds, flavonoid compounds, etc. These components can inhibit inflammatory reactions and relieve pain and swelling.

[0041] Antioxidant effect: The polyphenol compounds in Millettia reticulata have strong antioxidant effects, which can remove free radicals in the body and protect cells from oxidative damage. Anti-tumor effect: Some components in Millettia reticulata have anti-tumor effects, such as triterpenoids and flavonoids. These components can inhibit the growth and spread of tumor cells and improve the body's immunity.

[0042] Lipid-lowering effect: Some ingredients in Millettia spatholobi have lipid-lowering effects, such as triterpenoids and flavonoids. These ingredients can lower blood cholesterol and triglyceride levels and prevent cardiovascular diseases. Other effects: Millettia spatholobi also has antibacterial, antiviral, anti-allergic and other effects.

[0043] Compared with the prior art, the technical scheme of the present invention has the following beneficial effects: the Chinese medicine composition of the present invention is an oral Chinese medicine decoction, which directly acts on the facial muscles, improves the blood circulation of the diseased part, takes effect quickly, and recovers quickly, adding a new treatment idea of ​​oral Chinese medicine decoction, and strengthening the therapeutic effect of oral decoction. In the past, the treatment principle was mainly Western medicine plus Chinese medicine acupuncture, and Chinese medicine decoction was supplemented. This Chinese medicine composition can realize the treatment scheme of mainly Chinese medicine decoction and auxiliary acupuncture, and relieve the pain for patients.

[0044] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present invention more obvious and easy to understand, the following is a detailed description in combination with the preferred embodiments. DETAILED DESCRIPTION

[0045] The specific implementation modes of the present invention are described in detail below, which is a part of this specification. The principles of the present invention are explained through examples. Other aspects, features and advantages of the present invention will become clear through the detailed description.

[0046] The dosage and treatment course of the Chinese medicine composition of the present invention can select a suitable dosage group according to the patient's age, weight, and severity of the disease. The Chinese medicine composition is soaked for 15 to 25 minutes at 18 to 25°C, then boiled over high heat, then decocted over low heat for 20 to 30 minutes, filtered, and filtrate is obtained for standby use. The residue is then added with water, boiled over high heat, then decocted over low heat for 10 to 15 minutes, filtered, and the residue is discarded to obtain a filtrate. The two filtrates are combined and concentrated. The amount of water added for the first decoction is 6 to 10 times the total amount of the medicine, and the amount of water added for the second decoction is 3 to 4 times the total amount of the medicine, which is concentrated to one third of the amount of water added twice.

[0047] After the Chinese medicine composition described in the present invention is concentrated, it is taken three times a day. A course of treatment is three days, and the treatment lasts for 9 days.

[0048] Efficacy judgment criteria: HB grading standard is used. Cured: reaching HB I level, bilateral forehead lines and nasolabial folds are restored to symmetry, eyes are closed normally, no air leaks from the corners of the mouth when the cheeks are puffed, no crooked teeth, and normal facial expression; markedly effective: reaching HB II level, that is, bilateral forehead lines and nasolabial folds are basically symmetrical, eyes are not closed tightly, the corners of the mouth are slightly asymmetrical when the teeth are shown, and no air leaks from the corners of the mouth when the cheeks are puffed; improved: improved from H-BIV~VI level to above III level after treatment; ineffective: still remains above H-BIV level after treatment.

[0049] Treatment results: After taking the decoction of the present invention for 3 courses, 37 cases were cured and 3 cases were markedly effective.

[0050] There was 1 case of ineffectiveness. The cure rate reached 90%, and the total effective rate reached 97%.

[0051] Examples of contrastive treatments in Western medicine:

[0052] A female patient in her 60s who sells fruit received western medicine treatment for 3 days. After taking glucocorticoids for emergency treatment, her symptoms did not improve significantly, but her blood sugar rose to 23mmol / L. She was treated with a Chinese medicine formula (10g cinnamon twig, 10g white peony root, 8g licorice root, 15g jujube, 20g ginger, 10g kudzu root, 10g angelica root, 8g cimicifuga, 15g millettia reticulata, 6g platycodon) and her symptoms improved significantly after 3 days, leaving only a slightly asymmetrical mouth. After another 5 days of treatment with this formula, she recovered and did not relapse during follow-up.

[0053] A 47-year-old female patient who runs a restaurant received treatment with Western medicine, acupuncture, and oral Chinese medicine decoctions for one month. Except for the left eye that could not close well, all other symptoms of the patient have disappeared. Because the eyes could not close well, the patient was in great pain and had tears flowing out continuously. After taking a medium-dose Chinese medicine formula (10 grams of cinnamon twig, 10 grams of white peony root, 8 grams of licorice root, 15 grams of jujube, 20 grams of ginger, 10 grams of kudzu root, 10 grams of angelica root, 8 grams of cimicifuga, 15 grams of Millettia reticulata, 6 grams of Platycodon grandiflorum) for 7 days, the eyes could slowly close autonomously. After another 7 days of consolidation treatment, the eye closure function was restored. However, the patient's tearing problem was cured after stopping the medication for one month.

[0054] The raw materials listed in the present invention, as well as the upper and lower limits and interval values ​​of the raw materials of the present invention, and the upper and lower limits and interval values ​​of the process parameters (such as temperature, time, etc.) can all realize the present invention, and the embodiments are not listed one by one here.

[0055] The above is only a preferred embodiment of the present invention, which certainly cannot be used to limit the scope of rights of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and changes can be made without departing from the principle of the present invention, and these improvements and changes are also regarded as the protection scope of the present invention.

Claims

1. A Chinese medicine prescription for treating peripheral facial paralysis, characterized in that: It contains the following raw materials in grams: 12-20 grams of cinnamon twig, 5-20 grams of white peony root, 3-13 grams of roasted licorice root, 10-20 grams of jujube, 10-30 grams of ginger, 5-15 grams of kudzu root, 5-15 grams of angelica, 3-12 grams of cimicifuga, 5-20 grams of Millettia reticulata, and 2-10 grams of Platycodon grandiflorum.

2. The Chinese medicine prescription for treating peripheral facial paralysis as claimed in claim 1, characterized in that: The composition comprises the following raw materials in grams: 20 grams of cinnamon twig, 20 grams of white peony root, 13 grams of roasted licorice root, 20 grams of jujube, 30 grams of ginger, 15 grams of kudzu root, 15 grams of angelica dahurica, 12 grams of cimicifuga, 20 grams of Millettia reticulata, and 10 grams of Platycodon grandiflorum (high-dose group).

3. A Chinese medicine prescription for treating peripheral facial paralysis as claimed in claim 1, characterized in that The composition comprises the following raw materials in grams: 5 grams of cinnamon twig, 5 grams of white peony root, 3 grams of roasted licorice root, 10 grams of jujube, 10 grams of ginger, 5 grams of kudzu root, 5 grams of angelica dahurica, 3 grams of cimicifuga, 5 grams of Millettia reticulata, and 2 grams of Platycodon grandiflorum (low-dose group).

4. The Chinese medicine prescription for treating peripheral facial paralysis as claimed in claim 1, characterized in that The composition comprises the following raw materials in grams: 10 grams of cinnamon twig, 10 grams of white peony root, 8 grams of roasted licorice root, 15 grams of jujube, 20 grams of ginger, 10 grams of kudzu root, 10 grams of angelica dahurica, 8 grams of cimicifuga, 15 grams of Millettia reticulata, and 6 grams of Platycodon grandiflorum (medium dose group).

5. A method for preparing a Chinese medicine composition for treating peripheral facial paralysis, characterized in that: Add water to the raw material medicine described in the Chinese medicine formula for treating peripheral facial nerve paralysis as described in any one of claims 1 to 4, soak at 18-25° C. for 15-25 minutes, then boil over high heat, then turn to low heat, simmer for 20-30 minutes, filter, and obtain a filtrate for later use; add water to the filter residue, boil over high heat, then turn to low heat, simmer for 10-15 minutes, filter, discard the filter residue, obtain a filtrate, combine the two filtrates, and concentrate to obtain.

6. The method for preparing a Chinese medicine composition for treating peripheral facial paralysis as claimed in claim 5, characterized in that: The amount of water added in the first decoction is 6 to 10 times the total weight of the medicine, and the amount of water added in the second decoction is 3 to 4 times the total weight of the medicine, and it is concentrated to one third of the amount of water added twice.

7. Use of the composition according to any one of claims 1 to 4 in the preparation of a medicament for treating peripheral facial paralysis.

8. A medicine for treating peripheral facial paralysis, characterized in that: The invention comprises the composition according to any one of claims 1 to 4 or the composition prepared by the preparation method according to claims 5 to 6, and medically acceptable auxiliary materials.

9. The drug according to claim 8, characterized in that: The dosage forms of the medicine include traditional Chinese medicine preparations, granules, pills, tablets, oral liquids, capsules, powders and dusts.

10. The method for preparing the Chinese medicine preparation according to claim 9, characterized in that: The following steps are included: S1: Prepare medicinal materials: weigh the medicinal materials according to the Chinese medicine formula by weight, weigh 12-20 parts of cinnamon twig, 5-20 parts of white peony root, 3-13 parts of roasted licorice root, 10-20 parts of jujube, 10-30 parts of ginger, 5-15 parts of kudzu root, 5-15 parts of angelica, 3-12 parts of cimicifuga, 5-20 parts of millettia reticulata, 2-10 parts of platycodon, wash them separately, cut them into small pieces of 0.5-5 cm, and dry them in a cool place; S2: Soaking in water: Add water to the medicinal materials prepared in step S1 until the amount of water is 6 to 10 times the total weight of the medicinal materials, and soak at 18 to 25°C for 15 to 25 minutes; S3: primary water extraction: soak the mixture in the water of step S2, heat it to boiling, extract it by heat preservation, filter it, and concentrate the filtrate to obtain concentrated solution A; S4: Secondary water extraction: add water to the filter residue of step S3 to 3 to 4 times the total amount of the drug, heat to boiling, extract by heat preservation, filter, and concentrate the filtrate to obtain concentrated solution B; S5: Preparation: After the concentrated solution A and the concentrated solution B are mixed, auxiliary materials are added, and the mixture is packaged to prepare a Chinese medicine preparation.