Preparation method and device for osteogenesis-promoting and antibacterial zinc phosphate coating on zirconia implant surface

Abstract

The present invention belongs to the field of dental implants, and particularly relates to a preparation method and device for a bone-promoting and antibacterial zinc phosphate coating on the surface of a zirconia implant. The preparation steps of the phosphate coating include: S4: Mix zinc oxide, phosphoric acid, nitric acid and deionized water, and add an additive to prepare a phosphating solution; S5: Place the phosphating solution and the zirconia implant in a reaction kettle, and place the reaction kettle in an oven at 150-230°C and heat for 3-12 h, and take it out after natural cooling; S6: Ultrasonically clean with deionized water for 1-5 min, and place it in an oven at 40-60°C for drying, and finally obtain a zirconia implant coated with a zinc phosphate coating; By using the hydrothermal method to prepare a zinc phosphate coating on the surface of a zirconia dental implant, by changing the formula of the phosphating solution and adjusting the temperature and time of the hydrothermal reaction, it has good mechanical properties, cell compatibility, osteogenic properties and antibacterial properties, which is of great significance for expanding the clinical application of zirconia ceramic implant materials in the oral field.

Description

Technical Field

[0001] The present invention belongs to the field of dental implants, and particularly relates to a preparation method and device for an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconia implant. Background Art

[0002] For decades, titanium implants have been widely used in the field of oral restorative implants, but they have some obvious disadvantages: Titanium implants have a high elastic modulus, which can cause stress shielding effect, thus inhibiting bone regeneration and even leading to bone resorption; Titanium will undergo abrasion and release toxic aluminum and vanadium metal ions in the human oral electrolyte environment for a long time, causing allergic and inflammatory reactions to the tissues around the implant, and even causing local tissue pain and swelling; Titanium has a large color difference from natural teeth, which is not conducive to aesthetics and limits its application in the anterior tooth area and some patients with insufficient thickness of the mucosa around the implant, so the clinical use of titanium implants has been gradually restricted.

[0003] Zirconia ceramics have unique advantages in the field of dental ceramic restorative materials due to their high mechanical properties, good biocompatibility, excellent chemical stability and unique aesthetic properties, and are expected to replace titanium implants.

[0004] Dental ceramic restorations prepared by SLA have the characteristics of good surface quality, high density, high precision and excellent mechanical properties; However, due to its lack of bioactivity, this greatly limits the application and expansion of ceramic implants; Most of the methods for introducing bioactive components adopt the composite method, that is, zirconia powder and bioactive substances are directly mechanically mixed and then sintered at high temperature to form ceramics, so as to improve the bioactivity of zirconia, but the disadvantage of the direct composite method is that the strength of these active substances is generally low. Summary of the Invention

[0005] The purpose of the present invention is to provide a preparation method and device for an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconia implant in view of the above existing technical problems, achieving the effect of promoting the adhesion, proliferation and differentiation behaviors of osteoblasts and fibroblasts on its surface by changing the physical and chemical properties of the ceramic surface, and effectively improving its bioactivity and osseointegration.

[0006] In view of this, the present invention provides a preparation method for an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconia implant, including the following steps:

[0007] S1: Design a zirconia implant model through software, configure a slurry with nano-zirconia powder containing 3% mol yttrium and resin, and then prepare a green implant through a stereolithography forming technology printer, and the laser power is 0.3-2W;

[0008] S2: Use 75% ethanol to ultrasonically clean the green body for 1 - 5 min, and after ultrasonic cleaning, place it in an oven at a temperature of 100 - 250 °C for curing for 2 - 5 h to preliminarily remove part of the resin used as an adhesive;

[0009] S3: Transfer the green body to a muffle furnace at a temperature of 300 - 600 °C for degreasing for 1 - 4 h, then transfer the green body to a muffle furnace at a temperature of 1300 - 1600 °C for sintering for 3 - 5 h, and finally cool it to room temperature with the furnace to obtain a zirconia implant;

[0010] S4: Mix zinc oxide, phosphoric acid, nitric acid and deionized water, and add an additive to prepare a phosphating solution;

[0011] S5: Place the phosphating solution and the zirconia implant in a reaction kettle, and place the reaction kettle in an oven at 150 - 230 °C for heating for 3 - 12 h, and take it out after natural cooling;

[0012] S6: Use deionized water for ultrasonic cleaning for 1 - 5 min, and place it in an oven at 40 - 60 °C for drying, and finally obtain a zirconia implant coated with a zinc phosphate coating.

[0013] In the above technical solution, further:

[0014] The additive in S4 is one or more of MXene, HA and graphene.

[0015] In the above technical solution, further:

[0016] The MXene phase is M2XT x and M3XT x phases, and is in the form of a powder similar to the graphene structure;

[0017] where M is one or more of the transition metal elements Ti, Nb, Zr, Cu, Zn, Au, Ag, Mn and Mo with good biological activity; X is one or two of C and N; T x is one or more of the surface groups of -OH, -O, -F and -Cl

[0018] In the above technical solution, further:

[0019] The particle size of the HA phase is nanoscale or sub - micron scale.

[0020] In the above technical solution, further:

[0021] The graphene is in a single - layer or multi - layer structure.

[0022] In the above technical solution, further:

[0023] In the above technical solution, further:

[0024] In S4, the zinc oxide is 0.3 - 0.9 mol / L, phosphoric acid is 0.2 - 0.6 mol / L, nitric acid is 0.6 - 1.8 mol / L, the additive is 0.5 - 2 g / L, and the molar ratio of zinc oxide to phosphoric acid is 3:2.

[0025] The present invention provides a preparation device for an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconia implant, comprising:

[0026] An oven, including a box body and a heating mechanism installed on the inner wall of the box body;

[0027] A kettle body, installed inside the box body, and internally divided into a plurality of alternately arranged active stirring chambers and passive stirring chambers, with a feed pipe installed on the side and a discharge pipe installed on the bottom surface;

[0028] A stirring mechanism, installed inside the kettle body, and including a rotating shaft passing through a plurality of active stirring chambers and passive stirring chambers and stirring rods installed on the rotating shaft, and the stirring rods are located in the active stirring chambers;

[0029] A driving mechanism, installed on the oven, and used to drive the rotation of the rotating shaft;

[0030] Wherein, a partition net is provided between the active stirring chamber and the passive stirring chamber.

[0031] In the above technical solution, further, it further includes:

[0032] A feeding mechanism, inserted on the side of the kettle body, and including a first support net for supporting the zirconia implant and a cover plate for detachably connecting with the kettle body, and is correspondingly arranged with the passive stirring chamber;

[0033] A sealing strip, installed between the cover plate and the kettle body, and used for sealing connection between the cover plate and the kettle body;

[0034] A locking member, installed between the cover plate and the kettle body, and used for detachable connection between the cover plate and the kettle body;

[0035] Wherein, the first support net is provided with a notch for avoiding the rotating shaft when inserted into the kettle body, and a second support net is hinged on the inner wall of the notch.

[0036] In the above technical solution, further:

[0037] A plurality of strip-shaped holes are provided on the circumference of the cover plate. Among them, the locking member includes:

[0038] A clamping strip, rotatably connected to the side of the kettle body through a cylinder, and adapted to the strip-shaped holes;

[0039] An arc-shaped convex strip, installed on the surface of the cover plate, and used to generate static friction with the surface of the clamping strip under the action of the sealing strip when the clamping strip is perpendicular to the strip-shaped holes;

[0040] There are two arc-shaped convex strips, which are symmetrically arranged with each other, and one end of the symmetrical ends is chamfered.

[0041] In the above technical solution, further, the locking member also includes:

[0042] The limiting structure is installed on the arc-shaped convex strip and is used for limiting the position of the card strip and the strip hole after they are in a vertical state;

[0043] Among them, the limiting structure includes an embedding groove opened at one end of an arc-shaped convex strip away from its chamfered end and a protrusion arranged at another arc-shaped convex strip away from its chamfered end, and a toggle plate is installed in the embedding groove, and the toggle plate is hingedly connected to the arc-shaped convex strip and is used to press one end to drive the toggle plate to leave the embedding groove.

[0044] The beneficial effects of the present invention are:

[0045] 1. Zirconia dental implants were prepared by stereolithography (SLA) technology, and zinc phosphate coatings were prepared on their surfaces by hydrothermal method. By changing the formula of phosphating solution and adjusting the temperature and time of hydrothermal reaction, the implants had good mechanical properties, cell compatibility, osteogenic properties and antibacterial properties, which is of great significance for expanding the clinical application of zirconia ceramic implant materials in the oral field.

[0046] 2. Zinc phosphate can exert biological functionality by releasing zinc ions and phosphate ions after degradation. Among them, zinc plays a vital role in various biological functions; it is a component or activator of various enzymes, and participates in the regulation or catalysis of various biochemical reactions; in addition, zinc also plays an important role in bone metabolism and human growth; zinc supplementation can promote bone formation, and at the same time enhance bone strength by stimulating osteoblasts and inhibiting the differentiation of osteoclasts; while phosphate ions can provide a phosphorus source for bone proliferation, thereby promoting bone repair and regeneration.

[0047] 3. During the preparation of the zinc phosphate coating, the phosphating solution is properly stirred to improve the uniformity of the mixing of the various substances in the phosphating solution, reduce the concentration gradient in the kettle body, ensure the uniformity of the coating, and divide the kettle body into an active stirring chamber and a passive stirring chamber to avoid collision between the stirring rod and the zirconia implant when the stirring rod is stirring the phosphating solution, avoid damage to the coating on the surface of the zirconia implant, and ensure the quality of the coating. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 is an XRD diagram of the zirconium oxide implant with and without a zinc phosphate coating according to the present invention;

[0049] Figure 2It is the SEM image of the zirconia implant with or without a zinc phosphate coating of the present invention;

[0050] Figure 3 It is the surface scanning EDS chemical composition image of the zirconia implant with or without a zinc phosphate coating of the present invention;

[0051] Figure 4 It is the comparison chart of the flexural strength of the zirconia implant with or without a zinc phosphate coating of the present invention before and after aging;

[0052] Figure 5 It is the nano-scratch image of the zirconia implant with or without a zinc phosphate coating of the present invention;

[0053] Figure 6 It is the cell viability results after co-culturing the zirconia implant with or without a zinc phosphate coating of the present invention with MC3T3-E1 cells for 1, 3, and 5 days;

[0054] Figure 7 It is the in vitro osteogenic differentiation and mineralization results of the zirconia implant with or without a zinc phosphate coating of the present invention and titanium implant on MC3T3-E1 cells;

[0055] Figure 8 It is the CFU morphology image (A) of the zirconia implant with or without a zinc phosphate coating of the present invention, the CFU analysis result (B) of Staphylococcus aureus, and the CFU analysis result (C) of Escherichia coli after co-culturing with titanium implant;

[0056] Figure 9 It is the structural schematic diagram of the preparation device of the present invention;

[0057] Figure 10 It is the internal structural schematic diagram of the preparation device of the present invention;

[0058] Figure 11 It is the structural schematic diagram of the oven of the present invention;

[0059] Figure 12 It is the present invention Figure 11 The enlarged view of part A;

[0060] Figure 13 It is the structural schematic diagram of the feeding mechanism of the present invention;

[0061] The markings in the figure are as follows: 1. oven; 10. box body; 11. heating mechanism; 2. kettle body; 20. active stirring chamber; 21. passive stirring chamber; 22. feed pipe; 23. discharge pipe; 24. partition; 3. stirring mechanism; 30. rotating shaft; 31. stirring rod; 4. driving mechanism; 5. feeding mechanism; 50. first supporting net; 51. cover plate; 52. notch; 53. second supporting net; 54. strip hole; 6. sealing strip; 7. locking piece; 70. clamping strip; 71. cylinder; 72. arc-shaped convex strip; 73. limiting structure; 730. embedded groove; 731. protrusion; 732. toggle plate. DETAILED DESCRIPTION

[0062] The following will be combined with the drawings in the embodiments of the present application to clearly describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments in the present application belong to the scope of protection of this application.

[0063] Embodiment 1:

[0064] This embodiment provides a method for preparing an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconium oxide implant, comprising the following steps:

[0065] S1: The zirconia implant model was designed by software, and the slurry was formed by mixing nano-zirconia powder containing 3% mol of yttrium with resin. Then, the implant embryo was prepared by a stereolithography printer with a laser power of 1.5W.

[0066] S2: The embryo was ultrasonically cleaned with 75% ethanol for 5 minutes, and then placed in an oven at 120°C for curing for 2 hours to preliminarily remove part of the resin used as an adhesive;

[0067] S3: transferring the green embryo to a muffle furnace at a temperature of 600°C for degreasing for 4 hours, and then transferring the green embryo to a muffle furnace at a temperature of 1550°C for sintering for 3 hours, and finally cooling it to room temperature in the furnace to obtain a zirconia implant;

[0068] S4: mixing zinc oxide, phosphoric acid, nitric acid and deionized water, and adding additives to prepare a phosphating solution;

[0069] S5: placing the phosphating solution and the zirconium oxide implant in a reaction kettle, heating the reaction kettle in an oven at 200° C. for 6 h, and taking it out after natural cooling;

[0070] S6: ultrasonically clean the implant with deionized water for 1 min and dry it in an oven at 60°C to obtain a zirconia implant covered with a zinc phosphate coating;

[0071] The zirconia implants coated with zinc phosphate coatings prepared by the above method were compared with zirconia implants without zinc phosphate coatings and titanium implants;

[0072] Figure 1 As can be seen, after the hydrothermal reaction, a large amount of ZnP phase was formed on the surface of the implant, and the surface hydrothermal method could form a ZnP coating on the surface of the zirconia implant;

[0073] Figure 2 As can be seen, after the hydrothermal treatment, needle-like and granular crystals were visible on the surface of the specimen, and the surface was completely covered with crystals, and no basal zirconia was seen; it can be considered that a zinc phosphate coating was formed on the surface of the zirconia implant after the hydrothermal treatment, and the coating completely covered the zirconia substrate;

[0074] Figure 3 As can be seen, elements such as Zn, P, C, O, Zr, C, and Ti existed on the surface of the zirconia implant after the hydrothermal treatment, which indicated that there was a zinc phosphate coating on the surface of the implant after the hydrothermal treatment; at the same time, the contents of O, Zr, and Y decreased after the hydrothermal treatment, indicating that the zinc phosphate coating on the surface of the implant had a large coverage area;

[0075] Figure 4 As can be seen, although the strength of the zirconia implant decreased after the hydrothermal treatment, it was still 934 ± 46 MPa, which could meet the clinical requirements; an aging test was carried out on the zirconia implant before and after the treatment, and the results showed that the strength of the pure zirconia implant decreased significantly, by 35%, while the strength of the zirconia implant coated with zinc phosphate decreased only by 7.6%, and the difference was not statistically significant, indicating that the zinc phosphate coating could effectively prevent the aging phenomenon of the zirconia implant;

[0076] Figure 5 As can be seen, its coating thickness was 2.2 μm, and the coating adhesion was 71.5 MPa;

[0077] Figure 6 As can be seen, the data measured by the CCK-8 method after culturing MC3T3-E1 cells with the zirconia implant before and after the hydrothermal treatment for 1 d, 3 d, and 5 d showed that: the cell survival rate on the zirconia implant after the hydrothermal treatment exceeded 100%, and from the third day, the cell survival rate on the zirconia implant in the ZnP-loaded group was significantly higher than that on the zirconia implant without the coating, indicating that the zinc phosphate coating could effectively promote the proliferation of MC3T3-E1 cells;

[0078] Figure 7 As can be seen, the staining results of ALP after osteogenic induction and differentiation for 7 d ( Figure 7)showed that the staining depth of the zirconia implants with the coating was deeper than that of the pure titanium group and the pure zirconia group, indicating that the zirconia implants with the zinc phosphate coating could significantly promote the expression of alkaline phosphatase in MC3T3-E1 cells; the staining results of ARS after osteogenic induction and differentiation for 21 days ( Figure 7 )showed that the surfaces of the titanium implants and the zirconia implants without the coating were mainly unmineralized blank areas, only discrete spotted nodules were visible, and the color was relatively light. The number and area of the mineralized nodules on the surface of the zirconia implants with the coating were significantly increased, and the color was significantly deepened. The above results indicated that the zirconia implants with the zinc phosphate coating could significantly promote extracellular matrix mineralization, and its mineralization level was higher than that of the zirconia implants without the coating and the titanium implants; the above results indicated that the zinc phosphate coating showed good osteogenic promoting properties;

[0079] Figure 8 As can be seen from Figure 8 A at the place shown in (

[0080] ), the CFU counting results of the titanium implants, the zirconia implants without the coating and the zirconia implants with the coating were as shown in (

[0081] Example 2:

[0082] This example provided a preparation method for a zinc phosphate coating with osteogenic promoting and antibacterial properties on the surface of zirconia implants, including the following steps:

[0083] S1: Design the zirconia implant model through software, prepare a slurry with a solid content of 47% using nano-zirconia powder containing 3% mol yttrium and resin as raw materials, and then prepare the implant green body with a thickness of 50 um by a stereolithography technology 3D printer, and the laser power is 1.5W;

[0084] S2: Ultrasonically clean the green body with 75% ethanol for 5 minutes, and place it in an oven at a temperature of 120 °C for 2 hours after ultrasonic cleaning to preliminarily remove part of the resin as the binder;

[0085] S3: Transfer the green body to a muffle furnace at 500 °C for 3 h of debinding, then transfer the green body to a muffle furnace at 1550 °C for 4 h of sintering, and finally cool it in the furnace to room temperature to obtain a zirconia implant;

[0086] S4: Mix zinc oxide, phosphoric acid, nitric acid and deionized water to prepare a phosphating solution, where zinc oxide is 0.3 mol / L, graphene (single-layer structure) is 2 g / L, phosphoric acid is 0.5 mol / L, and nitric acid is 0.8 mol / L;

[0087] S5: Pour the phosphating solution into a reaction kettle, put the zirconia implant into it, then place the reaction kettle in an oven at 200 °C and heat for 3 h, and take it out after natural cooling;

[0088] S6: Ultrasonically clean with deionized water for 1 min, and dry it in an oven at 60 °C. Finally, obtain a zirconia implant coated with a zinc phosphate coating;

[0089] Control example:

[0090] S1: Design a zirconia implant model through software. Use nano-zirconia powder containing 3% mol yttrium and resin as raw materials to prepare a slurry with a solid content of 45%. Then use a stereolithography forming technology printer to prepare a green body of the implant, with a thickness of 50 um and a laser power of 0.5 W;

[0091] S2: Ultrasonically clean the green body with 75% ethanol for 5 min, and after ultrasonic cleaning, place it in an oven at 120 °C for 2 h of curing to preliminarily remove part of the resin used as an adhesive;

[0092] S3: Transfer the green body to a muffle furnace at 600 °C for 4 h of debinding, then transfer the green body to a muffle furnace at 1550 °C for 3 h of sintering, and finally cool it in the furnace to room temperature to obtain a zirconia implant;

[0093] S4: Mix zinc oxide, phosphoric acid, nitric acid and deionized water to prepare a phosphating solution, where zinc oxide is 0.5 mol / L, MXene with the composition of Mo2TiC is 2 g / L, phosphoric acid is 0.5 mol / L, and nitric acid is 0.7 mol / L;

[0094] S5: Pour the phosphating solution into a reaction kettle, put the zirconia implant into it, then place the reaction kettle in an oven at 250 °C and heat for 12 h, and take it out after natural cooling;

[0095] Results of this example: The flexural strength of the zirconia implant coated with zinc phosphate was 933 Mpa; the cell survival rates of MC3T3-E1 cells co-cultured with the zirconia implant coated with zinc phosphate for 3 days were 97.6%, 140.3%, and 168.5% respectively, showing good cell compatibility; the antibacterial rates of the zirconia implant coated with zinc phosphate co-cultured with Staphylococcus aureus and Escherichia coli for 1 day were 83.3% and 85.9% respectively, showing excellent antibacterial properties;

[0096] Results of the control example: It was found that the zirconia implant was broken when the autoclave was opened. This was mainly due to the low laser power, high hydrothermal temperature and long time, which caused defects in the printed green body and poor thermal stability.

[0097] Example 3:

[0098] This example provides a preparation device for a zinc phosphate coating on the surface of a zirconia implant to promote osteogenesis and antibacterial properties, including:

[0099] An oven 1, including a box body 10 and a heating mechanism 11 installed on the inner wall of the box body 10;

[0100] A kettle body 2, installed in the box body 10, and its interior is divided into a plurality of alternately arranged active stirring chambers 20 and passive stirring chambers 21, and a feed pipe 22 is installed on the side and a discharge pipe 23 is installed on the bottom surface;

[0101] A stirring mechanism 3, installed in the kettle body 2, and includes a rotating shaft 30 passing through a plurality of active stirring chambers 20 and passive stirring chambers 21 and stirring rods 31 installed on the rotating shaft 30, and the stirring rods 31 are located in the active stirring chambers 20;

[0102] A driving mechanism 4, installed on the oven 1, and used to drive the rotating shaft 30 to rotate;

[0103] Wherein, a partition net 24 is provided between the active stirring chamber 20 and the passive stirring chamber 21;

[0104] At the same time, the driving mechanism 4 can adopt a motor, and a gear transmission is used between it and the rotating shaft 30, and the heating mechanism 11 can adopt resistance wire heating. Its specific structure is a mature existing technology and will not be elaborated here.

[0105] As can be seen from this embodiment, by arranging the interior of the kettle body 2 into a plurality of alternately arranged active stirring chambers 20 and passive stirring chambers 21, and connecting them through a partition net 24, and corresponding the stirring rod 31 of the stirring mechanism 3 in the active stirring chamber 20, and placing the zirconia implant in the passive stirring chamber 21, it can effectively avoid that when the stirring rod 31 stirs the phosphating solution, it can drive most of the zirconia implants to move with the phosphating solution to a certain extent and be in a suspended state. On the one hand, it avoids the contact between the stirring rod 31 and the surface of the zirconia implant, avoiding affecting the coating on the surface of the zirconia implant. On the other hand, the stirring of the phosphating solution can effectively improve the mixing uniformity of each component of the phosphating solution, avoiding the appearance of a concentration gradient and affecting the uniformity of the coating on the surface of the zirconia implant. At the same time, it also improves the heating uniformity.

[0106] Example 4:

[0107] This embodiment provides a preparation device for an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconia implant. In addition to including the technical solutions of the above embodiments, it also has the following technical features, and further includes:

[0108] A feeding mechanism 5, inserted on the side of the kettle body 2, and includes a first support net 50 for supporting the zirconia implant and a cover plate 51 for detachably connecting with the kettle body 2, and is correspondingly arranged with the passive stirring chamber 21;

[0109] A sealing strip 6, installed between the cover plate 51 and the kettle body 2, and used for the sealed connection between the cover plate 51 and the kettle body 2;

[0110] A locking member 7, installed between the cover plate 51 and the kettle body 2, and used for the detachable connection between the cover plate 51 and the kettle body 2;

[0111] Among them, the first support net 50 is provided with a notch 52 for avoiding the rotating shaft 30 when inserting into the kettle body 2, and a second support net 53 is hinge-connected to the inner wall of the notch 52;

[0112] At the same time, the sealing strip 6 is made of rubber, and in order to ensure resistance to the erosion of the phosphating solution, fluororubber can be used. Its specific composition materials are existing mature technologies, and can endow the sealing strip 6 with better sealing performance, which will not be elaborated here.

[0113] As can be seen from this embodiment, by using the first support net 50 and the cover plate 51 for the feeding mechanism 5, that is, by first placing the zirconia implant on the first support net 50, and then inserting it into the passive stirring chamber 21, and then fixing the cover plate 51 and the kettle body 2 through the locking member 7, and the sealing strip 6 can ensure the sealed connection between the cover plate 51 and the kettle body 2, and then introducing the phosphating solution into the kettle body 2 to ensure the formation of the coating on the surface of the zirconia implant, improving the convenience;

[0114] The notch 52 on the first supporting net 50 facilitates the insertion of the first supporting net 50 into the kettle body 2 without being affected by the rotating shaft 30, and the second supporting net 53 hinged on the inner wall of the notch 52 can ensure the convenience of taking out the zirconia implant that has fallen into the notch 52 due to the stirring of the phosphating liquid after the surface coating of the zirconia implant is completed, that is, by moving the second supporting net 53, the zirconia implant on the second supporting net 53 falls onto the first supporting net 50, and then the second supporting net 53 is turned over and the loading mechanism 5 is taken out, thereby ensuring the unloading of the zirconia implant that has been coated.

[0115] Embodiment 5:

[0116] This embodiment provides a device for preparing an osteogenic and antibacterial zinc phosphate coating on the surface of a zirconium oxide implant. In addition to the technical solutions of the above embodiments, it also has the following technical features:

[0117] The cover plate 51 is provided with a plurality of strip-shaped holes 54 on its circumference, wherein the locking member 7 comprises:

[0118] The clamping strip 70 is rotatably connected to the side of the kettle body 2 by means of a cylinder 71 and is adapted to the strip-shaped hole 54;

[0119] The arc-shaped convex strip 72 is installed on the surface of the cover plate 51 and is used to generate static friction with the surface of the clamping strip 70 under the action of the sealing strip 6 when the clamping strip 70 is perpendicular to the strip-shaped hole 54;

[0120] There are two arc-shaped convex strips 72, which are symmetrically arranged with each other, and one end of the symmetrical ends is chamfered.

[0121] It can be seen from this embodiment that by using the clamping strip 70 as the locking member 7 and rotating it to connect it to the side of the kettle body 2, after the bar-shaped hole 54 on the cover plate 51 corresponds to it, the clamping strip 70 can be rotated to fix the cover plate 51, which is convenient.

[0122] In addition, the provision of the arc-shaped ridge 72 can increase the force of the clamping strip 70 on the cover plate 51, prompting the cover plate 51 to squeeze the sealing strip 6, thereby ensuring the sealing effect. At the same time, two arc-shaped ridges 72 are provided, which can effectively ensure the stability of the clamping strip 70 locking the cover plate 51, and the chamfering of one end of the arc-shaped ridge 72 can avoid restricting the rotation of the clamping strip 70, and at the same time can better guide the clamping strip 70 to move to the surface of the arc-shaped ridge 72, thereby applying force to the arc-shaped ridge 72 to squeeze the cover plate 51, thereby ensuring the sealing performance.

[0123] Embodiment 6:

[0124] This embodiment provides a preparation device for an osteogenesis-promoting and antibacterial zinc phosphate coating on the surface of a zirconia implant. In addition to the technical solutions of the above embodiment, it also has the following technical features. The locking member 7 further includes:

[0125] A limiting structure 73, which is installed on the arc-shaped rib 72 and is used for limiting the position after the clamping bar 70 and the strip-shaped hole 54 are in a vertical state;

[0126] Among them, the limiting structure 73 includes an embedding groove 730 opened at one end of the arc-shaped rib 72 away from its chamfer and a protrusion 731 provided at the other end of the arc-shaped rib 72 away from its chamfer. A toggle plate 732 is installed in the embedding groove 730, and the toggle plate 732 is hingedly connected to the arc-shaped rib 72 and is used to press one end to drive the toggle plate 732 out of the embedding groove 730;

[0127] Specifically, the setting of the embedding groove 730 will cause the end of the arc-shaped rib 72 away from the chamfer to form an abutting portion for restricting the movement of the clamping bar 70 after it enters the embedding groove 730, and this abutting portion and the protrusion 731 on the other arc-shaped rib 72 are on the same side, so as to perform two-way limiting on the clamping bar 70.

[0128] It can be seen from this embodiment that through the setting of the limiting structure 73, after the clamping bar 70 passes through the strip-shaped hole 54 and the locking of the cover plate 51 is completed, the clamping bar 70 can be limited, avoiding the loosening of the clamping bar 70, resulting in the failure of the locking member 7 and affecting the sealing performance;

[0129] And the limiting structure 73 is adopted with a protrusion 731 provided on one arc-shaped rib 72, an embedding groove 730 on the other arc-shaped rib 72 and a toggle plate 732. On the one hand, the protrusion 731 can prompt the clamping bar 70 and the strip-shaped block to finally be in a vertical state. On the other hand, the embedding groove 730 can make the other end of the clamping bar 70 move in place, so as to perform good limiting on the final state of the clamping bar 70. Then, the toggle plate 732 can press the end away from the clamping bar 70, so as to prompt the clamping bar 70 to move out of the embedding groove 730, so as to facilitate the rotation of the clamping bar 70 and realize the release of the locking member 7, with high convenience.

[0130] The embodiments of the present application have been described above in conjunction with the accompanying drawings. Without conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application is not limited to the above specific implementation manners. The above specific implementation manners are only illustrative and not restrictive. Under the inspiration of the present application, those of ordinary skill in the art can also make many forms without departing from the purpose of the present application and the scope protected by the claims, and all belong to the protection scope of the present application.

Claims

1. A preparation device for an osteogenesis-promoting and antibacterial zinc phosphate coating on the surface of a zirconia implant, characterized in that, Comprising: An oven (1), comprising a box body (10) and a heating mechanism (11) installed on the inner wall of the box body (10); A kettle body (2), installed inside the box body (10), and internally divided into a plurality of alternately arranged active stirring chambers (20) and passive stirring chambers (21), and a feed pipe (22) is installed on the side, and a discharge pipe (23) is installed on the bottom surface; A stirring mechanism (3), installed inside the kettle body (2), and comprising a rotating shaft (30) passing through a plurality of active stirring chambers (20) and passive stirring chambers (21) and stirring rods (31) installed on the rotating shaft (30), and the stirring rods (31) are located inside the active stirring chambers (20); A driving mechanism (4), installed on the oven (1), and used to drive the rotating shaft (30) to rotate; A feeding mechanism (5), inserted on the side of the kettle body (2), and comprising a first support net (50) for supporting the zirconia implant and a cover plate (51) for detachably connecting with the kettle body (2), and is arranged corresponding to the passive stirring chamber (21); A sealing strip (6), installed between the cover plate (51) and the kettle body (2), and used for sealing connection between the cover plate (51) and the kettle body (2); A locking member (7), installed between the cover plate (51) and the kettle body (2), and used for detachable connection between the cover plate (51) and the kettle body (2); Wherein, a partition net (24) is provided between the active stirring chamber (20) and the passive stirring chamber (21); The first support net (50) is provided with a notch (52) for avoiding the rotating shaft (30) when inserted into the kettle body (2), and a second support net (53) is hingedly connected to the inner wall of the notch (52).

2. The preparation device for promoting osteogenesis and antibacterial zinc phosphate coating on the surface of zirconia implants according to claim 1, characterized in that: A plurality of strip-shaped holes (54) are provided on the circumference of the cover plate (51), wherein, the locking member (7) comprises: A clamping strip (70), rotatably connected to the side of the kettle body (2) through a cylinder (71), and adapted to the strip-shaped holes (54); An arc-shaped convex strip (72), installed on the surface of the cover plate (51), and used to generate static friction with the surface of the clamping strip (70) under the action of the sealing strip (6) when the clamping strip (70) is perpendicular to the strip-shaped holes (54); Wherein, there are two arc-shaped convex strips (72), which are symmetrically arranged, and chamfers are provided at both symmetric ends.

3. The preparation device for promoting osteogenesis and antibacterial zinc phosphate coating on the surface of zirconia implants according to claim 2, characterized in that, The locking member (7) further comprises: A limiting structure (73), installed on the arc-shaped convex strip (72), and used for limiting after the clamping strip (70) is in a vertical state with the strip-shaped holes (54); Among them, the limiting structure (73) includes an embedding groove (730) formed at one end of an arc-shaped convex strip (72) away from its chamfer, and a protrusion (731) provided at one end of the other arc-shaped convex strip (72) away from its chamfer. A toggle plate (732) is installed in the embedding groove (730). The toggle plate (732) is hinged to the arc-shaped convex strip (72) and is used to press one end to drive the toggle plate (732) out of the embedding groove (730).

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