Automated analyzer

Abstract

The automatic analysis device (1) is provided with a B / F separation unit (104), a reaction liquid suction nozzle (106), and a replacement liquid discharge nozzle (108), the B / F separation unit (104) is configured so as to be movable in the vertical direction and the horizontal direction, or is provided with a B / F separation unit (104), a reaction liquid suction nozzle (106), a replacement liquid discharge nozzle (108), a photometric unit (134), a measurement flow path introduction nozzle (130), a cleaning liquid storage container (122), and a buffer liquid storage container (120). The B / F separation unit (104), the cleaning liquid storage container (122), and the buffer liquid storage container (120) are mounted on the turntable (102). As a result, an automatic analysis device is provided in which the number of movable axes is reduced compared to the prior art.

Description

Technical Field

[0001] The present invention relates to an automatic analysis device. Background Art

[0002] There is a technique in which an automatic analyzer for analyzing biological components is provided with a magnetic separation unit, a nozzle for removing excess marker substances, and a nozzle for discharging a replacement fluid (see Patent Document 1). Prior art literature Patent Literature

[0003] Patent Document 1: International Publication No. 2020 / 235162 Summary of the invention Technical problem to be solved by the invention

[0004] According to Patent Document 1, it is not considered to reduce the number of axes of the actuator corresponding to the complex movement of the nozzle to achieve miniaturization of the automatic analysis device.

[0005] Therefore, an object of the present invention is to provide an automatic analyzing device capable of reducing the number of movable axes. Technical solutions to technical problems

[0006] An automatic analysis device according to one embodiment of the present invention includes: a magnetic separation unit that captures magnetic particles in a first container that contains a reaction solution mixed with reagents and samples; a first nozzle that attracts a first liquid in the first container; and a second nozzle that discharges a second liquid into the first container that has attracted the first liquid, wherein the magnetic separation unit is configured to be movable in vertical and horizontal directions. Effects of the Invention

[0007] According to the present invention, it is possible to provide an automatic analysis device capable of reducing the number of movable axes. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1 It is a diagram showing a schematic structure of an automatic analyzer. Figure 2 This is a top view of the analysis action section. Figure 3 It is a side view of the analysis action part. Figure 4 It is another brief top view of the analysis action part. Figure 5 It is another brief side view of the real analysis action part. Figure 6 Here is another brief overhead view of the analysis action section. DETAILED DESCRIPTION

[0009] use Figures 1 to 6 In the drawings used in this specification, the same or similar reference numerals are given to the same or corresponding components, and repeated description of these components may be omitted.

[0010] First, use Figure 1 The overall structure of the automatic analysis device will be described below. Figure 1 It is a diagram showing a schematic structure of an automatic analyzer.

[0011] The automatic analyzer 1 is composed of a control unit 10 and an analysis operation unit 20. The automatic analyzer 1 has the following functions: a plurality of reagent containers 31 are stored along the inner side of the outer peripheral wall of a cylindrical reagent storage 30 supported so as to be freely rotatable around a vertical axis, a predetermined amount of a predetermined reagent is sucked from each reagent container 31 by a dispensing pipette, and supplied to a biological sample such as blood or urine dispensed into a reaction container 51 for analysis.

[0012] First, the transfer path of the sample to be analyzed will be described.

[0013] The sample to be analyzed is moved in the automatic analyzer 1 by a sample transport mechanism (omitted for convenience of illustration) such as a conveyor belt or a rack carrier while being stored in a sample container 40, and is transported to a sample dispensing mechanism 41 having a dispensing pipette for dispensing the sample for dispensing.

[0014] The plurality of reaction containers 51 are provided to the automatic analyzer 1 in a state of being placed in the unused reaction container storage unit 50 .

[0015] The reaction containers 51 are held one by one by the reaction container conveying mechanism 52 from the unused reaction container storage unit 50, and then moved to the buffer 42 (the sample discharge position of the sample dispensing mechanism 41), and the reaction containers 51 on the buffer 42 are also moved to the reaction container holding position 43. In order to perform such movement, the reaction container conveying mechanism 52 is configured to be able to move in the X-axis ( Figure 1 Left and right directions in the Y axis ( Figure 1 The front-to-back direction) and the Z axis ( Figure 1 Move in the up and down directions.

[0016] The disc-shaped incubator 25 rotatably supported about a vertical center axis has a plurality of reaction container mounting portions 26 for securing a plurality of reaction containers 51 on a circumference near the outer circumference. By rotating the incubator 25 , each reaction container 51 can be moved to a predetermined position.

[0017] Next, the sample dispensing mechanism 41 moves to the upper area of ​​the sample, sucks the sample, and then moves to the upper area of ​​the reaction container 51 on the buffer 42 to discharge the sample into the reaction container 51. After that, the sample dispensing mechanism 41 uses a cleaning mechanism (not shown) to clean the nozzle of the dispensing pipette. When a replaceable needle is used instead of a nozzle, the needle can also be replaced by a replacement mechanism (not shown).

[0018] Next, the transfer path of the reagent added to the sample in the reaction container 51 will be described.

[0019] As its moving range, the conveying mechanism 60 is constructed to be able to make circular motions within the range of the buffer 42, the reaction container holding position 43, the reagent discharge position 33 of the reagent dispensing mechanism 32, the reaction container setting part 26 on the incubator 25 and the B / F (Bound / Free) separation part 104 of the analysis part 100, and can rotate to convey the reaction container 51 to these positions.

[0020] The reagent storage 30 is cylindrical and rotatably supported around a vertical central axis, and the inner side is a hollow cavity, and a reagent holding portion 34 is formed along the shell 38 of the inner cavity to radially hold a plurality of reagent containers 31. In addition, a part of the reagent container 31 also contains a reagent containing a large number of magnetic particles for stirring. The details of its structure will be described later.

[0021] The reagent dispensing mechanism 32 is configured to be movable so as to suck the reagent in the reagent container 31 and move it to a predetermined position. First, the reagent dispensing mechanism 32 moves to the upper area of ​​the reagent of a predetermined type on the reagent storage 30 to suck a predetermined amount of the reagent, and then moves to the upper area of ​​the reaction container 51 set at the reagent discharge position 33 set around the incubator 25 and discharges the reagent into the reaction container 51.

[0022] A stirring mechanism (not shown) for the reagent is provided at the upper part of the reagent storage 30. In the stirring mechanism, a magnetic particle stirring arm (also called a stirrer) that can rotate around a vertical axis is provided. The magnetic particle stirring arm moves to the upper area of ​​the reagent container 31 containing the reagent to be stirred containing magnetic particles, so that the magnetic particle stirring mechanism, such as a paddle-shaped or spiral-shaped one, provided at the lower end of the magnetic particle stirring arm is lowered into the reagent, and the magnetic particle solution is stirred by rotating the magnetic particle stirring mechanism. In order to prevent the magnetic particles in the solution from naturally precipitating, the magnetic particle stirring arm stirs the magnetic particles just before the reagent is dispensed. After stirring, the magnetic particle stirring arm rises to the upper part of the reagent container 31, moves to the upper area of ​​the cleaning mechanism containing the cleaning solution, and after descending into the cleaning solution, the magnetic particle stirring mechanism is rotated to remove the magnetic particles attached to the stirring mechanism.

[0023] After the sample and the predetermined reagent are dispensed and a predetermined reaction time has passed, a reaction solution is formed, and the reaction container 51 containing the reaction solution is moved to the B / F separation unit 104 of the analysis unit 100 by the transport mechanism 60 .

[0024] The B / F separation unit 104 is a portion that captures magnetic particles in the reaction container 51 that contains a reaction solution mixed with reagents and samples. More specifically, it is a mechanism that magnetically adsorbs magnetic particles containing a substance that is immunologically bound to a measurement object present in the reaction solution in the reaction container 51 that is transported by the transport mechanism 60 onto the inner wall of the reaction container 51 through the magnet 105, thereby separating the reaction solution that does not contain magnetic particles from the magnetic particles.

[0025] The reaction liquid suction nozzle 106 sucks the reaction liquid in the reaction container 51 and is configured to be rotatable and movable up and down. It moves and descends above the reaction container 51 after a predetermined time has passed on the B / F separation unit 104 to suck the reaction liquid that does not contain magnetic particles in the reaction container 51 .

[0026] The replacement fluid discharge nozzle 108 discharges the replacement fluid into the reaction container 51 that has attracted the reaction fluid. The nozzle 108 is configured to be rotatable and movable up and down. On the B / F separation unit 104 , the nozzle 108 moves above the reaction container 51 that has attracted the reaction fluid not containing magnetic particles and descends to discharge the buffer solution into the reaction container 51 .

[0027] The stirring mechanism (not shown) mixes the magnetic particles and the buffer solution in the reaction container by applying a rotational motion to the reaction container 51. The mixed reaction container 51 is conveyed to the lower side of the measurement flow channel introduction nozzle 130 by the rotational motion of the turntable 102.

[0028] The measurement channel introduction nozzle 130 is a nozzle that can rotate and move up and down, and is used to suck the reaction liquid in the reaction container 51 and introduce it to the photometry unit 134 .

[0029] The photometric unit 134 detects the concentration of the detection target in the reaction liquid introduced into the measurement flow path and sent by the nozzle.

[0030] Next, the reaction container 51 holding the reaction solution to be analyzed is moved to the upper region of the reaction container disposal port (not shown) by the reaction container transport mechanism 52, and the reaction container 51 is disposed of in the reaction container disposal unit (not shown) through the reaction container disposal port.

[0031] Figure 1 The automatic analyzer 1 shown can efficiently analyze a plurality of samples for a plurality of analysis items by combining or repeating the above-mentioned operations.

[0032] The mechanism described above in the automatic analyzer 1 is referred to as an analysis operation unit 20 .

[0033] Furthermore, the automatic analyzer 1 includes a control unit 10 for controlling the operation of each device in the automatic analyzer 1 in addition to the analysis operation unit 20. The control unit 10 includes an operation unit 11, a processing unit 12, and a storage unit 13.

[0034] The processing unit 12 is constituted by, for example, a hardware substrate and a computer, and has a built-in storage unit 13 such as a hard disk.

[0035] The storage unit 13 stores, for example, control parameters corresponding to each unit, sample information related to various samples, and the like.

[0036] The processing unit 12 can be constituted by a dedicated circuit substrate as hardware, or it can be constituted by software executed by a computer. In the case of being constituted by hardware, it can be realized by integrating multiple operators that perform processing onto a wiring substrate, or into a semiconductor chip or package. In the case of being constituted by software, it can be realized by mounting a high-speed general-purpose CPU on a computer and executing a program for performing the desired calculation processing. It is also possible to upgrade the existing device using a storage medium storing the program. In addition, these devices, circuits, and computers are connected by a wired or wireless network to perform appropriate data transmission and reception.

[0037] The operation unit 11 is composed of a display unit, namely a monitor, and input units such as a mouse and a keyboard. Various information related to the automatic analyzer 1 stored in the storage unit 13 is displayed on the display unit.

[0038] The above is the configuration of the automatic analyzer 1 according to the present embodiment.

[0039] In addition, although the structure of the automatic analyzer is mentioned, Figure 1 The present invention is not limited to the case of a photometric unit 134 that performs immune system analysis as shown in the figure, but the structure of the automatic analysis device to which the present invention is applied is not limited to this. For example, it can also be applied to an automatic analysis device that further or alternatively includes a detection unit for a biochemical system, or a detection unit for a biochemical system and a detection unit for an immune system, as well as detection units for other analysis items.

[0040] In addition, the automatic analysis device is not limited to Figure 1 The single analysis module structure shown above may be connected to two or more analysis modules capable of measuring various identical or different analysis items or pre-processing modules capable of performing pre-processing via a transmission device.

[0041] Next, use Figures 2 to 6 The analysis unit 100 in the automatic analyzer 1 will be described in detail. Figure 2 and Figure 4 This is a top view of the analysis action section. Figure 3 and Figure 5This is a simplified side view of the analysis action section. Figure 6 This is a top view of the analysis action unit of another method.

[0042] like Figures 2 to 5 As shown, the analysis unit 100 includes a turntable 102, a B / F separation unit 104, a reaction liquid suction nozzle 106, a replacement liquid discharge nozzle 108, a photometric unit 134, a measurement flow path introduction nozzle 130, a cleaning liquid storage container 122, a buffer storage container 120, an LFC (Liquid Flow Cleaning) container 124, a measurement flow path pump 136, a reaction liquid suction / replacement liquid discharge pump 140, a nozzle rotation motor 144, a rotating shaft 146, a turntable rotation motor 150, a turntable up and down motor 152, a rotating shaft 154, etc.

[0043] The buffer storage container 120 is disposed on the turntable 102 and is a container for storing a buffer containing a luminescent matrix.

[0044] The cleaning liquid storage container 122 is provided on the turntable 102 , and is a container for storing a cleaning liquid for cleaning the flow path from the measurement flow path introduction nozzle 130 to the photometric unit 134 .

[0045] The LFC container 124 is provided on the turntable 102 and is a container for storing a flow path cleaning liquid for cleaning the reaction liquid suction nozzle 106 and the measurement flow path introduction nozzle 130. The LFC container 124 is provided with a partition plate 124a for dividing the flow path cleaning liquid into the cleaning liquid for the reaction liquid suction nozzle 106 and the cleaning liquid for the measurement flow path introduction nozzle 130.

[0046] In this embodiment, the B / F separation unit 104 is mounted on a turntable 102 on which a reaction container setting unit 110 for setting a reaction container 51 on the turntable 102, a buffer storage container 120, a cleaning liquid storage container 122, an LFC container 124, etc. are placed, and is constructed to be able to move in the vertical direction and the horizontal direction together with these reaction container setting unit 110, etc.

[0047] In addition, if Figure 2 or Figure 4 As shown, on the turntable 102 , the reaction container installation part 110 , the cleaning liquid storage container 122 , the buffer storage container 120 , the LFC container 124 , and the B / F separation part 104 are radially arranged around the rotation axis 154 of the turntable 102 .

[0048] When the measurement channel introduction nozzle 130 is located vertically above the buffer storage container 120, the arrangement interval is set so that the conveying mechanism 60 is located vertically above the B / F separation unit 104. On this basis, when the measurement channel introduction nozzle 130 sucks the buffer from the buffer storage container 120, the conveying mechanism 60 controls its operation to place the reaction container 51 on the B / F separation unit 104 or to collect the reaction container 51 from the B / F separation unit 104.

[0049] Furthermore, the orbit of the B / F separation unit 104 based on the rotational operation of the turntable 102 is arranged to intersect with the orbit of the reaction liquid suction nozzle 106 and the orbit of the replacement liquid discharge nozzle 108 .

[0050] Next, the operation of the B / F separation cycle in the automatic analyzer 1 will be described.

[0051] First, if Figure 2 As shown, the reaction container 51 is set in the B / F separation unit 104 by the conveying mechanism 60. Since the B / F separation unit 104 is equipped with a magnet 105, at this time, the magnetic particles in the reaction solution held in the reaction container 51 are captured by the magnet 105, and the magnetic particles and other substances are separated.

[0052] Afterwards, if Figure 4 As shown, the turntable 102 is driven by the turntable rotating motor 150 so as to rotate around the rotating shaft 154 , and the B / F separation unit 104 is moved to below the reaction liquid suction nozzle 106 .

[0053] The turntable 102 is driven by the turntable up and down motor 152, so that the turntable 102 rises. Figure 5 As shown, the reaction liquid suction nozzle 106 is inserted into the reaction container 51 of the B / F separation unit 104 .

[0054] Then, the reaction liquid suction / substitution liquid discharge pump 140 is driven to suction the reaction liquid that has not been captured by the B / F separation unit 104 .

[0055] Next, after the turntable 102 is lowered by driving the turntable up-and-down motor 152 , the nozzle rotating motor 144 is driven to rotate and move the replacement fluid discharge nozzle 108 about the rotating shaft 146 to the top of the B / F separation unit 104 .

[0056] Next, the turntable up-and-down motor 152 is driven to raise the turntable 102 again, and the replacement fluid discharge nozzle 108 is inserted into the reaction container 51 of the B / F separation unit 104 .

[0057] Thereafter, the replacement fluid drawn from the replacement fluid bottle 142 is discharged into the reaction container 51 in the B / F separation unit 104 using the reaction fluid suction / replacement fluid discharge pump 140 .

[0058] Next, a case where the detection cycle and the B / F separation cycle in the automatic analyzer 1 overlap will be described.

[0059] During the measurement cycle, the turntable 102 is driven by the turntable rotation motor 150 so as to rotate around the rotation axis 154. Figure 2 and Figure 3 As shown in FIG. 1 , the reaction container installation section 110 is moved to a position directly below the measurement channel introduction nozzle 130 .

[0060] Then, the measurement channel pump 136 is driven to suck the reaction solution set in the reaction vessel setting section 110 and introduce it into the measurement channel 132 .

[0061] Thereafter, the turntable 102 is moved upward by driving the turntable up-and-down motor 152 , and the measurement channel introduction nozzle 130 is inserted into the buffer storage container 120 to suck the buffer solution.

[0062] Finally, while the turntable 102 is driven to rise by the turntable up-and-down motor 152 and the buffer solution is sucked, the reaction container 51 is set and recovered in the B / F separation unit 104 by the transport mechanism 60 .

[0063] In addition, if Figures 2 to 5 As shown, the turntable 102 can rotate and move up and down, and the cleaning liquid storage container 122, the buffer storage container 120 and the B / F separation unit 104 are not limited to being arranged radially around the rotation axis 154 of the turntable 102. Figure 6 As shown, the workbench 102A can move horizontally and vertically, and the cleaning liquid storage container 122, the buffer storage container 120 and the B / F separation unit 104 can also be arranged along the horizontal movement direction of the workbench 102A.

[0064] Next, the effects of this embodiment will be described.

[0065] The automatic analyzer 1 comprises: a B / F separation unit 104, which captures magnetic particles in a reaction container 51 containing a reaction solution mixed with a reagent and a sample; a reaction solution suction nozzle 106, which sucks the reaction solution (first liquid) in the reaction container 51; and a replacement liquid discharge nozzle 108, which discharges the replacement liquid (second liquid) into the reaction container 51 that has sucked the reaction solution. The B / F separation unit 104 is configured to be movable in the vertical direction and the horizontal direction, or comprises: a B / F separation unit 104, which captures magnetic particles in a reaction container 51 containing a reaction solution mixed with a reagent and a sample; ; a reaction liquid suction nozzle 106, which sucks the reaction liquid in the reaction container 51; a replacement liquid discharge nozzle 108, which discharges the replacement liquid into the reaction container 51 that has attracted the reaction liquid; a photometric unit 134; a measurement flow path introduction nozzle 130, which introduces the reaction liquid into the photometric unit 134; a cleaning liquid storage container 122, which stores a cleaning liquid for cleaning the flow path from the measurement flow path introduction nozzle 130 to the photometric unit 134; and a buffer storage container 120, which stores a buffer solution containing a luminescent matrix. The B / F separation unit 104, the cleaning liquid storage container 122 and the buffer storage container 120 are mounted on the turntable 102.

[0066] Therefore, the reaction liquid suction nozzle 106 and the replacement liquid discharge nozzle 108 do not need to be moved up and down during B / F separation, and the up and down movement of the turntable 102 can be used for both, so the number of axes can be reduced. This effect can reduce the temperature control space by reducing the size of the device, improve the temperature control efficiency, and reduce costs.

[0067] In addition, the turntable 102 can rotate and move up and down, and the cleaning liquid storage container 122, the buffer storage container 120 and the B / F separation part 104 are arranged radially with the rotating shaft 154 of the turntable 102 as the center. Therefore, these structures can be accessed only by rotation, and the size of the turntable 102 can be suppressed from increasing.

[0068] In addition, the workbench 102A can rotate and move up and down, and the cleaning liquid storage container 122, the buffer storage container 120 and the B / F separation unit 104 are arranged axially along the horizontal movement direction of the workbench 102A. Therefore, these structures can be accessed only by horizontal movement, and the size of the workbench 102A can be suppressed from increasing.

[0069] In addition, by intersecting the orbit of the B / F separation section 104 with the orbit of the reaction liquid suction nozzle 106 and the orbit of the replacement liquid discharge nozzle 108, the required action can be achieved with the minimum required driving mechanism or movable axis, which can shorten the analysis action and further miniaturize the device.

[0070] Furthermore, an LFC container 124 is provided on the turntable 102 and stores a channel cleaning liquid for cleaning the reaction liquid suction nozzle 106 and the measurement channel introduction nozzle 130, thereby enabling the configuration required for the immunoassay item to be efficiently arranged in a smaller space.

[0071] In addition, in the LFC container 124, by providing a partition plate 124a for dividing the channel cleaning liquid into the liquid for cleaning the reaction liquid suction nozzle 106 and the liquid for cleaning the measurement channel introduction nozzle 130, the necessary structure can be efficiently arranged in a small space.

[0072] In addition, it also includes a conveying mechanism 60 for conveying the reaction container 51 to the B / F separation section 104. When the measurement flow path introduction nozzle 130 is located vertically above the buffer storage container 120, the conveying mechanism 60 is located vertically above the B / F separation section 104. Or it also includes a conveying mechanism 60 for conveying the reaction container 51 to the B / F separation section 104. When the measurement flow path introduction nozzle 130 attracts the buffer from the buffer storage container 120, the conveying mechanism 60 is controlled to set the reaction container 51 on the B / F separation section 104, or the reaction container 51 is recovered from the B / F separation section 104. As a result, the detection cycle can be overlapped with a part of the B / F separation cycle, and the cycle time can be shortened even if the up and down actions are used together.

[0073] <Other> The present invention is not limited to the above-described embodiments, but includes various modifications. The above-described embodiments are described in detail to explain the present invention in an easy-to-understand manner, and the present invention is not limited to include all the described structures.

[0074] In addition, a part of the structure of a certain embodiment can be replaced with the structure of another embodiment, and the structure of another embodiment can be added to the structure of a certain embodiment. In addition, for a part of the structure of each embodiment, other structures can be added, deleted, or replaced.

[0075] For example, there is no limitation on the number of the B / F separator 104, the reaction liquid suction nozzle 106, the replacement liquid discharge nozzle 108, the photometry unit 134, the measurement channel introduction nozzle 130, the cleaning liquid storage container 122, the buffer storage container 120, the LFC container 124, etc. For example, a method of providing one reaction liquid suction nozzle 106 or a replacement liquid discharge nozzle 108 in the middle of two B / F separators 104 can be adopted. Description of symbols

[0076] 1 Automatic analysis device 10. Control Unit 11 Operation section 12 Processing Department 13 Storage 20 Analysis Action Department 25 Incubator 26 Reaction container installation part 30 Reagent Library 31 Reagent Container 32 Reagent dispensing mechanism 33 Reagent discharge position 40 Sample Containers 41 Sample dispensing mechanism 42 Buffer 43 Reaction vessel holding position 50 Unused reaction container storage 51 reaction container (first container) 52 reaction container conveying mechanism 60 conveying mechanism (conveying unit) 100 Analysis Department 102 Turntable (storage base) 102A workbench (storage base) 104B / F separation section (magnetic separation section) 105 Magnet 106 reaction liquid suction nozzle (first nozzle) 108 displacement fluid discharge nozzle (second nozzle) 110 reaction container installation unit 120 buffer storage container (third container) 122 cleaning liquid storage container (second container) 124 LFC container 124a Divider 130 Measurement flow path introduction nozzle (detection unit introduction nozzle) 132 Measurement flow path 134 photometric unit (detection unit) 136 Measurement flow pump 140 Substitution fluid discharge pump 142 Replacement fluid bottle 144 Nozzle Rotation Motor 146 Rotation axis 150 Turntable Rotary Motor 152 Turntable up and down motor 154 Rotation axis.

Claims

1. An automatic analysis device, characterized in that: include: A magnetic separation unit that captures magnetic particles in a first container containing a reaction solution in which a reagent and a sample are mixed; a first nozzle, the first nozzle sucking the first liquid in the first container; as well as a second nozzle configured to discharge the second liquid into the first container into which the first liquid has been sucked; The magnetic separation unit is configured to be movable in the vertical direction and the horizontal direction.

2. The automatic analysis device according to claim 1, characterized in that include: Testing Department; a detection section introduction nozzle, the detection section introduction nozzle introducing the reaction liquid into the detection section; a second container storing a cleaning liquid for cleaning a flow path from the detection portion introduction nozzle to the detection portion; a third container storing a buffer solution containing a luminescent substrate; as well as A reservoir base is provided with the magnetic separator, the second container, and the third container.

3. An automatic analysis device, characterized in that: include: A magnetic separation unit that captures magnetic particles in a first container containing a reaction solution in which a reagent and a sample are mixed; a first nozzle, the first nozzle sucking the first liquid in the first container; a second nozzle configured to discharge a second liquid into the first container that has attracted the first liquid; Testing Department; a detection section introduction nozzle, the detection section introduction nozzle introducing the reaction liquid into the detection section; a second container storing a cleaning liquid for cleaning a flow path from the detection portion introduction nozzle to the detection portion; a third container storing a buffer solution containing a luminescent substrate; as well as A reservoir base is provided with the magnetic separator, the second container, and the third container.

4. The automatic analysis device according to claim 2 or 3, characterized in that: The reservoir base is rotatable and vertically movable, and the second container, the third container, and the magnetic separator are radially arranged around a rotation axis of the reservoir base.

5. The automatic analysis device according to claim 2 or 3, characterized in that: The reservoir base is rotatable and vertically movable, and the second container, the third container, and the magnetic separator are arranged along an axial direction of a horizontal moving direction of the reservoir base.

6. The automatic analysis device according to claim 2 or 3, characterized in that: The trajectory of the magnetic separation unit intersects with the trajectory of the first nozzle and the trajectory of the second nozzle.

7. The automatic analysis device according to claim 6, characterized in that The device further comprises an LFC container, which is disposed on the reservoir base and stores a flow path cleaning liquid for cleaning the first nozzle and the detection portion introduction nozzle.

8. The automatic analysis device according to claim 7, characterized in that The LFC container includes a partition plate that divides the flow path cleaning fluid into a fluid for cleaning the first nozzle and a fluid for cleaning the detection portion introduction nozzle.

9. The automatic analysis device according to claim 2 or 3, characterized in that: It also includes a conveying unit that conveys the first container to the magnetic separation unit. When the detection unit introduction nozzle is located above the third container in the vertical direction, the conveying unit is located above the magnetic separation unit in the vertical direction.

10. The automatic analysis device according to claim 2 or 3, characterized in that: It also includes a conveying unit that conveys the first container to the magnetic separation unit. When the detection unit introduction nozzle sucks the buffer solution from the third container, the transport unit is controlled to place the first container on the magnetic separation unit or to recover the first container from the magnetic separation unit.

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