Gastrointestinal symptom prediction system

Abstract

The invention relates to the technical field of medical data processing, and discloses a gastrointestinal symptom prediction system. The change trend of the superior mesenteric artery ultrasonic data and the middle cerebral artery ultrasonic data of the person to be tested is compared with the change trend of the superior mesenteric artery ultrasonic data and the middle cerebral artery ultrasonic data of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms in the corresponding gestational age range; the method can accurately predict whether the to-be-detected neonates have gastrointestinal symptoms, is helpful for deeply knowing the gastrointestinal conditions of the neonates, provides reliable data guidance for clinical care of the neonates, and reduces the probability that the neonates suffer from gastrointestinal diseases.

Description

Technical Field

[0001] The present invention relates to the technical field of medical data processing, and in particular to a gastrointestinal symptom prediction system. Background Art

[0002] With the continuous improvement of medical technology, premature infants (PI) and very low birth weight (VLBW) infants weighing less than 1500g have become the most important part of the neonatal intensive care unit (NICU). They need individualized treatment and meticulous care due to their small gestational age, low weight and complex condition. Timely nutrition and proper feeding can not only reduce the incidence of early complications, especially neonatal necrotizing enterocolitis (NEC), but also have an important impact on long-term prognosis. The gastrointestinal organs of newborns are still relatively immature after birth. The size of the stomach is small and the secretion of gastric acid is limited, which limits their ability to digest and absorb large amounts of food. In addition, the barrier function of the gastric mucosa is not strong enough and is easily affected by external stimuli and infection. The surface area of ​​the small intestine is relatively small, which limits the ability to absorb nutrients. Therefore, it is necessary to pay attention to their gastrointestinal symptoms at all times. At present, medical staff observe the gastrointestinal symptoms of newborns, which is inefficient and inaccurate.

[0003] Therefore, there is an urgent need for a gastrointestinal symptom prediction system to assist in understanding the gastrointestinal symptoms of newborns, provide data guidance for the clinical care of newborns, and reduce the probability of newborns suffering from gastrointestinal diseases. Summary of the invention

[0004] The present invention provides a gastrointestinal symptom prediction system, which is used to solve the defects of low efficiency and poor accuracy in observing the gastrointestinal symptoms of newborns by medical staff at present.

[0005] The present invention provides a gastrointestinal symptom prediction system, comprising:

[0006] The first data receiving module is used to: receive Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of a subject at different gestational ages from at least one terminal, wherein the subject is a newborn;

[0007] The first data processing module is used to obtain the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages;

[0008] The prediction module is used to: obtain a prediction result of whether the subject has gastrointestinal symptoms based on the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and using a preset judgment standard;

[0009] The data output module is used to send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal.

[0010] According to a gastrointestinal symptom prediction system provided by the present invention, the prediction module includes:

[0011] The trend obtaining submodule is used to obtain the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages;

[0012] The determination submodule is used to: compare the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject to be tested with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms according to the preset determination criteria, so as to obtain a prediction result of whether the subject to be tested has gastrointestinal symptoms.

[0013] According to a gastrointestinal symptom prediction system provided by the present invention, the superior mesenteric artery ultrasound data includes any one of the following or any combination thereof: the maximum flow velocity during systole of the superior mesenteric artery, the minimum flow velocity during diastole of the superior mesenteric artery, and the resistance index of the superior mesenteric artery.

[0014] According to a gastrointestinal symptom prediction system provided by the present invention, different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth.

[0015] According to a gastrointestinal symptom prediction system provided by the present invention, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the neonatal group without gastrointestinal symptoms and the neonatal group with gastrointestinal symptoms in the corresponding gestational age range include:

[0016] The maximum systolic velocity and the minimum diastolic velocity of the middle cerebral artery from the first day after birth to the seventh day after birth in the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms increased, and the resistance index in the cerebral artery decreased.

[0017] According to a gastrointestinal symptom prediction system provided by the present invention, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the neonatal group without gastrointestinal symptoms and the neonatal group with gastrointestinal symptoms in the corresponding gestational age range include:

[0018] On the first day after birth, the superior mesenteric artery resistance index of both the neonatal group with and without gastrointestinal symptoms was lower than the middle cerebral artery resistance index. On the third and seventh days after birth, the superior mesenteric artery resistance index of the neonatal group with gastrointestinal symptoms was higher than the middle cerebral artery resistance index, while the superior mesenteric artery resistance index of the neonatal group without gastrointestinal symptoms was lower than the middle cerebral artery resistance index.

[0019] According to a gastrointestinal symptom prediction system provided by the present invention, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the neonatal group without gastrointestinal symptoms and the neonatal group with gastrointestinal symptoms in the corresponding gestational age range include:

[0020] On the first day after birth, the superior mesenteric artery resistance index increased in the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms. On the third and seventh days after birth, the superior mesenteric artery resistance index increased in the newborn group without gastrointestinal symptoms, while the superior mesenteric artery resistance index decreased in the newborn group with gastrointestinal symptoms.

[0021] According to a gastrointestinal symptom prediction system provided by the present invention, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the neonatal group without gastrointestinal symptoms and the neonatal group with gastrointestinal symptoms in the corresponding gestational age range include:

[0022] From the first day to the seventh day after birth, the maximum systolic flow velocity of the superior mesenteric artery increased in both the neonatal group with and without gastrointestinal symptoms. On the third and seventh days after birth, the minimum diastolic flow velocity of the superior mesenteric artery in the neonatal group with gastrointestinal symptoms was greater than that in the neonatal group without gastrointestinal symptoms, and the resistance index of the superior mesenteric artery in the neonatal group with gastrointestinal symptoms was lower than that in the neonatal group without gastrointestinal symptoms.

[0023] According to a gastrointestinal symptom prediction system provided by the present invention, the preset judgment criteria include: the preset judgment criteria include: when the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the subject to be tested are consistent with the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the group of newborns without gastrointestinal symptoms in the corresponding gestational age range, it is judged that the subject to be tested has no gastrointestinal symptoms; when the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the subject to be tested are consistent with the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the group of newborns with gastrointestinal symptoms in the corresponding gestational age range, it is judged that the subject to be tested has developed gastrointestinal symptoms.

[0024] In a specific embodiment, the newborn can be a full-term newborn. In another embodiment, the newborn can also be a premature infant, especially a very low birth weight infant. The present invention is particularly suitable for predicting gastrointestinal symptoms in premature infants, especially very low birth weight infants.

[0025] A gastrointestinal symptom prediction system provided by the present invention also includes:

[0026] The first cause analysis module is used to: when the prediction result is that the subject has developed gastrointestinal symptoms, obtain the cause of the subject's gastrointestinal symptoms based on the minimum flow rate of the superior mesenteric artery of the subject during diastole.

[0027] A gastrointestinal symptom prediction system provided by the present invention also includes:

[0028] The second data receiving module is used to receive the gastric bubble sonogram of the subject before and after feeding;

[0029] The second data processing module is used to obtain the gastric emptying rate and gastric emptying time of the subject according to the gastric bubble sonogram of the subject before and after feeding;

[0030] The second cause analysis module is used to: when the prediction result is that the subject has developed gastrointestinal symptoms, combine the gastric emptying rate and gastric emptying time of the subject to obtain the cause of the gastrointestinal symptoms of the subject.

[0031] The present invention further provides an electronic device, comprising a processor and a memory storing a computer program, wherein the processor implements the following steps when executing the computer program:

[0032] receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0033] According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained;

[0034] According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained;

[0035] The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

[0036] The present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, which implements the following steps when executed by a processor:

[0037] receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0038] According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained;

[0039] According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained;

[0040] The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

[0041] The present invention also provides a computer program product, the computer program product comprising a computer program, the computer program can be stored on a non-transitory computer readable storage medium, and when the computer program is executed by a processor, the computer can perform the following steps:

[0042] receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0043] According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained;

[0044] According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained;

[0045] The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

[0046] It should be noted that the terminal refers to an input and output device connected to a computer system. Depending on the function, the terminal can be divided into several types: smart terminal or intelligent terminal, dumb terminal, interactive terminal or online terminal. The terminal can specifically be various mobile communication devices, such as mobile phones, tablet computers, etc. The purpose of this article is to provide users with the function of inputting data and obtaining data output.

[0047] The present invention provides a gastrointestinal symptom prediction system, which compares the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the test subject with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms, so as to accurately predict whether the newborn to be tested will have gastrointestinal symptoms, which helps to deeply understand the gastrointestinal condition of the newborn, provide reliable data guidance for the clinical care of the newborn, and reduce the probability of newborns suffering from gastrointestinal diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0049] Figure 1 A schematic diagram of the structure of a system for constructing a gastrointestinal symptom prediction model provided by the present invention.

[0050] Figure 2A Schematic diagram of the comparison of PSV of SMA and MCA between the experimental group and the control group. Figure 2B This is a schematic diagram comparing the EDV of SMA and MCA between the experimental group and the control group. Figure 2C This is a schematic diagram showing the comparison of RI of SMA and MCA between the experimental group and the control group.

[0051] Figure 3 This is the second schematic diagram comparing the RI of SMA and MCA between the experimental group and the control group.

[0052] Figure 4 This is a schematic structural diagram of an electronic device provided by the present invention. DETAILED DESCRIPTION

[0053] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the drawings in the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments, and they should not be understood as limitations on the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. In the description of the present invention, it should be understood that the terms used are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0054] Figure 1A schematic diagram of the structure of a gastrointestinal symptom prediction system provided by the present invention.

[0055] See also Figure 1 The present invention provides a gastrointestinal symptom prediction system, which may include:

[0056] The first data receiving module is used to: receive Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of a subject at different gestational ages from at least one terminal, wherein the subject is a newborn;

[0057] The first data processing module is used to obtain the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages. In this embodiment, the superior mesenteric artery ultrasound data includes any one of the following items or any combination thereof: the maximum flow velocity during systolic period of the superior mesenteric artery, the minimum flow velocity during diastolic period of the superior mesenteric artery, and the resistance index of the superior mesenteric artery. The different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth.

[0058] The prediction module is used to: obtain a prediction result of whether the subject has gastrointestinal symptoms based on the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and using a preset judgment standard;

[0059] The data output module is used to send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal.

[0060] In one embodiment, the prediction module includes:

[0061] The trend obtaining submodule is used to obtain the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages;

[0062] The determination submodule is used to: compare the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject to be tested with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms according to the preset determination criteria, so as to obtain a prediction result of whether the subject to be tested has gastrointestinal symptoms.

[0063] Among them, the changing trends of the superior mesenteric artery ultrasound data of the newborn groups without gastrointestinal symptoms and the newborn groups with gastrointestinal symptoms in the corresponding gestational age range can include:

[0064] The maximum systolic velocity and the minimum diastolic velocity of the middle cerebral artery increased, and the resistance index of the cerebral artery decreased in the newborns without gastrointestinal symptoms and the newborns with gastrointestinal symptoms from the first day after birth to the seventh day after birth.

[0065] On the first day after birth, the superior mesenteric artery resistance index increased in the newborns without gastrointestinal symptoms and those with gastrointestinal symptoms. On the third and seventh days after birth, the superior mesenteric artery resistance index increased in the newborns without gastrointestinal symptoms and decreased in the newborns with gastrointestinal symptoms.

[0066] From the first day to the seventh day after birth, the maximum systolic flow velocity of the superior mesenteric artery increased in both the neonates without gastrointestinal symptoms and those with gastrointestinal symptoms. On the third and seventh days after birth, the minimum diastolic flow velocity of the superior mesenteric artery in the neonates with gastrointestinal symptoms was greater than that in the neonates without gastrointestinal symptoms, and the resistance index of the superior mesenteric artery in the neonates with gastrointestinal symptoms was less than that in the neonates without gastrointestinal symptoms.

[0067] On the first day after birth, the superior mesenteric artery resistance index of both the neonatal group with and without gastrointestinal symptoms was lower than the middle cerebral artery resistance index. On the third and seventh days after birth, the superior mesenteric artery resistance index of the neonatal group with gastrointestinal symptoms was higher than the middle cerebral artery resistance index, while the superior mesenteric artery resistance index of the neonatal group without gastrointestinal symptoms was lower than the middle cerebral artery resistance index.

[0068] Specifically, the preset judgment criteria include: when the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject are consistent with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the newborn group with no gastrointestinal symptoms in the corresponding gestational age range, it is judged that the subject has no gastrointestinal symptoms; when the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject are consistent with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the newborn group with gastrointestinal symptoms in the corresponding gestational age range, it is judged that the subject has developed gastrointestinal symptoms.

[0069] When using the gastrointestinal symptom prediction system, medical staff can obtain the superior mesenteric artery Doppler ultrasound images and middle cerebral artery Doppler ultrasound images of newborns at different gestational ages in advance and input them into the gastrointestinal symptom prediction system, which is received by the first data receiving module, and after data processing and prediction by the first data processing module and the prediction module, the data output module outputs the prediction result of whether the subject has gastrointestinal symptoms. Medical staff can formulate a suitable care plan for the newborn based on the prediction results output by the gastrointestinal symptom prediction system and their own judgment of the newborn, which can improve the work efficiency of medical staff and improve the accuracy of the care plan, thereby ensuring reasonable care for the newborn and reducing the probability of illness in the newborn.

[0070] In one embodiment, the gastrointestinal symptom prediction system may further include:

[0071] The first cause analysis module is used to: when the prediction result is that the subject has developed gastrointestinal symptoms, obtain the cause of the subject's gastrointestinal symptoms based on the minimum flow rate of the superior mesenteric artery of the subject during diastole.

[0072] In one embodiment, the gastrointestinal symptom prediction system may further include:

[0073] The second data receiving module is used to receive the gastric bubble sonogram of the subject before and after feeding;

[0074] The second data processing module is used to obtain the gastric emptying rate and gastric emptying time of the subject according to the gastric bubble sonogram of the subject before and after feeding;

[0075] The second cause analysis module is used to: when the prediction result is that the subject has developed gastrointestinal symptoms, combine the gastric emptying rate and gastric emptying time of the subject to obtain the cause of the gastrointestinal symptoms of the subject.

[0076] This example selects 176 newborns admitted to Beijing Chaoyang Hospital affiliated to Capital Medical University from January 2018 to January 2023, including 90 males and 86 females. According to the inclusion and exclusion criteria, the enrolled children are divided into two groups. The experimental group (i.e., the group of newborns with gastrointestinal symptoms) is the group with gastrointestinal symptoms during hospitalization, and the control group (i.e., the group of newborns without gastrointestinal symptoms) is the group with no gastrointestinal symptoms during hospitalization. The superior mesenteric artery (SMA) and the middle cerebral artery (MCA) are measured by color Doppler ultrasound on the first day, third day, and seventh day after birth, and the peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) of the two are compared. The results show that the SMA in different time periods has statistical differences in the comparison between the experimental group and the control group, and there are also statistical differences in SMA between different time periods of the same group of children (statistical value: P value); MCA only has statistical differences between different time periods of the same group of children (statistical value: P value). The PSV and EDV of MCA increased slowly over time, and the RI decreased accordingly. From the third day to the seventh day, the RI dropped below 0.80. The PSV of the experimental group and the control group of SMA increased slowly, while the EDV and RI were different between the experimental group and the control group (statistical value: P value). The EDV of the experimental group was greater than that of the control group on the third and seventh days, and the RI of the experimental group was less than that of the control group on the third and seventh days. If the RI of SMA and MCA are compared, the RI value of SMA is less than that of MCA in both the experimental group and the control group on the first day after birth; a change occurs on the third and seventh days after birth, and the RI value of SMA in the experimental group is greater than that of MCA, and the RI value of SMA in the control group is less than that of MCA (statistical value: P value). Therefore, the present invention believes that color Doppler ultrasound monitoring of hemodynamic changes in the superior mesenteric artery and gastric emptying can play an important role in gastrointestinal diseases in premature infants.

[0077] Therefore, this example includes the ultrasound data of the superior mesenteric artery of these 176 newborns. Among them, the gestational age was 28-34 weeks, with an average gestational age of (28.13±5.6) weeks; the average weight was (1.36±0.57) kg. Inclusion criteria: (1) Diagnosis: All children met the diagnosis of premature infants and very low birth weight infants; (2) The family members of the children signed the informed consent form; (3) Color Doppler ultrasound monitoring of the hemodynamics of the superior mesenteric artery SMA and the middle cerebral artery (MCA). Exclusion criteria: (1) Children with birth defects and congenital diseases; (2) Children who could not undergo ultrasound examination due to various factors. The enrolled group was divided into two groups. The experimental group had gastrointestinal symptoms (including abdominal distension, bloody stools, abdominal tenderness or stiffness [1-4]) during hospitalization, and the control group had no gastrointestinal symptoms during hospitalization. All patients were treated with warming, respiratory support, infection prevention and treatment, symptomatic support, etc. according to the doctor's advice.

[0078] This embodiment uses a Doppler color ultrasound instrument (Hitachi, Japan) with a 7.5MHz imaging and 5MHz Doppler transducer. A linear array probe (2-9MHz) or a small convex array probe (2-8MHz) is used to measure the superior mesenteric artery. The child is in a supine position and the probe is placed below the xiphoid process of the child; a small convex array probe (2-8MHz) is used to measure the middle cerebral artery and is placed in the temporal part of the child. A clear image of the blood vessel is obtained in real-time ultrasound and correction is made for the angle of incidence. According to the recorded Doppler tracings, the peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV) and resistance index (RI) are obtained by the peak velocity envelope of 5 consecutive heart cycles. Of note, Doppler ultrasound measurement of the superior mesenteric artery was performed during cardiopulmonary stability (defined as mean arterial blood pressure 30 mmHg, continuous oxygen saturation monitoring of 88%–95%, and / or recent blood gas analysis showing a pH of 7.25, a PaCO2 of 4.6–7 kPa, and a PaO2 of 7–10 kPa).

[0079] This embodiment uses a linear array probe (2-9MHz), the child is in a supine position, the probe is placed on the left hypochondrium of the child, below the spleen, and the sonogram of the gastric bubble is displayed. The maximum diameter of the transverse and longitudinal sections is taken to calculate the volume to obtain the gastric content. The volume is measured before feeding, immediately after feeding, and every 5 minutes after feeding until the gastric content volume is the same as the volume before feeding and no longer changes, usually before the next feeding. The 5-minute gastric emptying rate and gastric emptying time are calculated.

[0080] In this embodiment, SPSS26.0 statistical software was used to perform statistical analysis on all data. The measurement data that conformed to the normal distribution were expressed as mean ± standard deviation, and the non-normal distribution data were expressed as quartiles. For the measurement data that obeyed the normal distribution, the two groups of data were compared using the t test; for the measurement data that did not obey the normal distribution, the two groups of data were compared using the Mann-Whitney U rank sum test. P < 0.05 was considered statistically significant.

[0081] Multiple comparisons between the experimental group and the control group are shown in Table 1. There was no statistical difference in weight comparison; there was a statistical difference in gestational age comparison. In this example, the experimental group and the control group were compared for PSV, EDV and RI on the first, third and seventh days, respectively. The results showed that SMA at different time periods was statistically different between the experimental group and the control group, and there was also a statistical difference in SMA between different time periods of the same group of children; MCA was only statistically different between different time periods of the same group of children.

[0082] Table 1. Comparison of SMA and MCA between the experimental group and the control group

[0083]

[0084]

[0085] Note: *: PSV comparison; **: EDV comparison; ***: RI comparison

[0086] The changing trends of PSV, EDV and RI of SMA and MCA in the experimental group and the control group are as follows Figure 2A , 2B As shown in Figure 2C, it can be seen that regardless of the experimental group or the control group, the PSV and EDV of MCA slowly increased over time, and the RI decreased accordingly. From the third day to the seventh day, the RI dropped below 0.80; the PSV of the SMA experimental group and the control group both increased slowly, while there were differences in EDV and RI between the experimental group and the control group. The EDV of the experimental group was greater than that of the control group on the third and seventh days, and the RI of the experimental group was less than that of the control group on the third and seventh days.

[0087] If the RI of SMA and MCA are compared (as shown in Table 2), it can be found that on the first day after birth, the RI value of SMA is smaller than that of MCA in both the experimental and control groups; a change occurs on the third and seventh days after birth, with the RI value of SMA in the experimental group being larger than that of MCA, and the RI value of SMA in the control group being smaller than that of MCA; the RI value of SMA in the experimental group decreases, while that in the control group increases (as shown in Table 2). Figure 3 ).

[0088] Table 2. Comparison of RI between SMA and MCA

[0089]

[0090] Note: *: experimental group comparison; **: control group comparison

[0091] This embodiment compares the changing trends of the superior mesenteric artery ultrasound data of the subjects at different gestational ages with the changing trends of the superior mesenteric artery ultrasound data of the groups of newborns without gastrointestinal symptoms and the groups of newborns with gastrointestinal symptoms in the corresponding gestational age ranges, which can accurately predict whether the newborns to be tested will have gastrointestinal symptoms, help to gain a deeper understanding of the gastrointestinal conditions of the newborns, provide reliable data guidance for the clinical care of newborns, and reduce the probability of newborns suffering from gastrointestinal diseases.

[0092] Premature infants, especially very low birth weight infants, are an important part of patients in the neonatal intensive care unit (NICU). Due to their own immature development, it takes a long time to place a gastric tube for treatment and feeding. Premature infants have slow gastric emptying, high reflux rate, and more apnea associated with feeding. This embodiment shows that the perfusion flow rate of the superior mesenteric artery is low and the resistance index is high in the early stage of birth; as the birth time increases, the intestinal perfusion flow rate of the newborn slowly increases, and the resistance index gradually increases, which is higher than the middle cerebral artery resistance index, and gradually approaches normal children, but if the child has gastrointestinal symptoms, the resistance index will tend to be flat, which is less than the middle cerebral artery resistance index, and the intestinal blood vessels are stagnant. This also confirms that premature infants have small stomach capacity, poor gastrointestinal motility, and are prone to vomiting, abdominal distension, gastric retention, and even necrotizing enterocolitis.

[0093] The condition of children, especially newborns, develops rapidly. Whether it improves or worsens, it often happens in an instant. This embodiment effectively combines the color Doppler of the superior mesenteric artery with that of the middle cerebral artery. On the one hand, MCA has now become a routine examination item for newborns, and ultrasound physicians who perform pediatric examinations can master it very skillfully. The timing of SMA measurement is selected on the first, third, and seventh days after birth to correspond to the internationally recognized examination time of the brain, which is convenient for comparing the results of the superior mesenteric artery with the results of the color Doppler of the brain. On the other hand, the middle cerebral artery itself is a project worthy of close attention in newborns, especially premature infants. It changes quickly and has high sensitivity. MCA can reflect a variety of newborn brain diseases such as hypoxic-ischemic encephalopathy and cerebral edema at an early stage.

[0094] PSV is the highest flow rate during systole, that is, the highest blood flow per second, which can reflect the blood flow of organ perfusion; EDV is the lowest flow rate during diastole, that is, the blood flow after vasodilation. This example shows that when the child has gastrointestinal symptoms, the EDV flow rate in the experimental group is higher than that in the control group, that is, blood stasis occurs. It can be inferred that the cause of gastrointestinal complications in premature infants is intestinal blood stasis and decreased intestinal blood circulation.

[0095] Figure 4 An example of a physical structure diagram of an electronic device is shown in FIG. Figure 4 As shown, the electronic device may include: a processor 810, a communication interface 820, a memory 830 and a communication bus 840, wherein the processor 810, the communication interface 820 and the memory 830 communicate with each other through the communication bus 840. The processor 810 may call the logic instructions in the memory 830 to perform the following steps:

[0096] receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0097] According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained;

[0098] According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained;

[0099] The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

[0100] In addition, the logic instructions in the above-mentioned memory 830 can be implemented in the form of a software functional unit and can be stored in a computer-readable storage medium when it is sold or used as an independent product. Based on such an understanding, the technical solution of the present invention, in essence, or the part that contributes to the prior art or the part of the technical solution, can be embodied in the form of a software product, and the computer software product is stored in a storage medium, including a number of instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) to perform all or part of the steps of the method described in each embodiment of the present invention. The aforementioned storage medium includes: U disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), disk or optical disk and other media that can store program codes.

[0101] On the other hand, the present invention further provides a computer program product, the computer program product comprising a computer program, the computer program can be stored on a non-transitory computer readable storage medium, and when the computer program is executed by a processor, the computer can perform the following steps:

[0102] receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0103] According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained;

[0104] According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained;

[0105] The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal. In another aspect, the present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, which is executed by a processor to perform the following steps:

[0106] receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0107] According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained;

[0108] According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained;

[0109] The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

[0110] The device embodiments described above are merely illustrative, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Ordinary technicians in this field can understand and implement it without paying creative labor.

[0111] Through the description of the above implementation methods, those skilled in the art can clearly understand that each implementation method can be implemented by means of software plus a necessary general hardware platform, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solution is essentially or the part that contributes to the prior art can be embodied in the form of a software product, and the computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a disk, an optical disk, etc., including a number of instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in each embodiment or some parts of the embodiments.

[0112] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A gastrointestinal symptom prediction system, characterized in that: include: The first data receiving module is used to: receive Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of a subject at different gestational ages from at least one terminal, wherein the subject is a newborn; The first data processing module is used to obtain the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages; The prediction module is used to: obtain a prediction result of whether the subject has gastrointestinal symptoms based on the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and using a preset judgment standard; The data output module is used to send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal.

2. The gastrointestinal symptom prediction system according to claim 1, characterized in that: The prediction module includes: The trend obtaining submodule is used to obtain the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages; The determination submodule is used to: compare the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject to be tested with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms according to the preset determination criteria, so as to obtain a prediction result of whether the subject to be tested has gastrointestinal symptoms.

3. The gastrointestinal symptom prediction system according to claim 2, characterized in that: The superior mesenteric artery ultrasound data include any one of the following or any combination thereof: the maximum systolic flow velocity of the superior mesenteric artery, the minimum diastolic flow velocity of the superior mesenteric artery, and the resistance index of the superior mesenteric artery. The middle cerebral artery ultrasound data include any one of the following or any combination thereof: the maximum systolic flow velocity of the middle cerebral artery, the minimum diastolic flow velocity of the middle cerebral artery, and the resistance index of the middle cerebral artery.

4. The gastrointestinal symptom prediction system according to claim 3, characterized in that: Different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth.

5. The gastrointestinal symptom prediction system according to claim 4, characterized in that: The change trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms include: On the first day after birth, the superior mesenteric artery resistance index of both the neonatal group with and without gastrointestinal symptoms was lower than the middle cerebral artery resistance index. On the third and seventh days after birth, the superior mesenteric artery resistance index of the neonatal group with gastrointestinal symptoms was higher than the middle cerebral artery resistance index, while the superior mesenteric artery resistance index of the neonatal group without gastrointestinal symptoms was lower than the middle cerebral artery resistance index.

6. The gastrointestinal symptom prediction system according to claim 4, characterized in that: The change trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms include: On the first day after birth, the superior mesenteric artery resistance index increased in the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms. On the third and seventh days after birth, the superior mesenteric artery resistance index increased in the newborn group without gastrointestinal symptoms, while the superior mesenteric artery resistance index decreased in the newborn group with gastrointestinal symptoms.

7. The gastrointestinal symptom prediction system according to claim 4, characterized in that: The change trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms include: From the first day to the seventh day after birth, the maximum systolic flow velocity of the superior mesenteric artery increased in both the neonatal group with and without gastrointestinal symptoms. On the third and seventh days after birth, the minimum diastolic flow velocity of the superior mesenteric artery in the neonatal group with gastrointestinal symptoms was greater than that in the neonatal group without gastrointestinal symptoms, and the resistance index of the superior mesenteric artery in the neonatal group with gastrointestinal symptoms was lower than that in the neonatal group without gastrointestinal symptoms.

8. The gastrointestinal symptom prediction system according to any one of claims 1 to 7, characterized in that: The preset judgment criteria include: when the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the subject are consistent with the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the newborn group without gastrointestinal symptoms, it is judged that the subject has no gastrointestinal symptoms; when the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the subject are consistent with the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the newborn group with gastrointestinal symptoms, it is judged that the subject has developed gastrointestinal symptoms.

9. An electronic device comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein: When the processor executes the program, the following steps are implemented: receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages; According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained; According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained; The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

10. A non-transitory computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the following steps are implemented: receiving, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages; According to the Doppler ultrasound images of the superior mesenteric artery and the Doppler ultrasound images of the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the ultrasound data of the middle cerebral artery of the subject at different gestational ages are obtained; According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, the prediction result of whether the subject has gastrointestinal symptoms is obtained; The prediction result of whether the subject has gastrointestinal symptoms is sent to at least one terminal.

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