Low-dosage emulsifier composition capable of wrapping high-content grease and application

Abstract

The invention discloses a low-dosage emulsifier composition capable of wrapping high-content grease and application, stable cream and emulsion can be prepared only by using a low-dosage sucrose fatty acid ester emulsifier, the cream and the emulsion are kept stable under a centrifugal test, the dosage of the emulsifier can be reduced, and the cost is reduced; the composition also shows excellent stability under a high-temperature condition, can maintain the stability of cream and emulsion, and is of great significance to long-term storage and use of products. And the prepared cream is mild and non-irritant, and can meet the requirement of high safety in the market.

Description

Technical Field

[0001] The present invention relates to the field of emulsification technology in the field of cosmetics and external preparations, and in particular to an emulsifier composition compounded by specific sucrose fatty acid esters and application thereof. Background Art

[0002] The oil-in-water (O / W) system is a commonly used emulsification system in topical creams and emulsions. It disperses the oil phase in the water phase to form an emulsified structure with oil as the inner phase and water as the continuous outer phase. It is the most commonly used dosage form in the preparation of cosmetics and topical preparations. When emulsifying products with high oil content, traditional emulsifiers often require a higher addition amount to achieve a satisfactory emulsification effect, which not only increases costs, but may also affect the skin feel, stability and safety of the final product. Therefore, the development of a low-addition, high-performance emulsifier has become an urgent need in the industry.

[0003] Sucrose fatty acid ester emulsifiers are made by the esterification reaction of sucrose and fatty acids. Their molecular structure has both hydrophilic sucrose groups and lipophilic fatty acid chains. This unique amphiphilic structure enables sucrose fatty acid ester emulsifiers to effectively arrange at the water-oil interface, reduce interfacial tension, and promote the dispersion and stability of oil droplets in the water phase. Sucrose fatty acid ester emulsifiers have the characteristics of good moisturizing, refreshing skin feel, good safety, and environmental sustainability, but the disadvantage is that the emulsification performance is poor. Summary of the invention

[0004] The purpose of the present invention is to provide an emulsifier composition and application that can encapsulate high-content oil at a low dosage in order to solve the above problems. The present invention can add a high proportion of oil, oil-soluble active ingredients, and water-soluble active ingredients at a low dosage of the sucrose ester emulsifier composition, and the prepared product paste is delicate and low in irritation, which can meet the market's demand for high safety and high activity. The emulsifier composition compounded by the present invention through specific sucrose fatty acid esters greatly improves the emulsification performance.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0006] An emulsifier composition capable of encapsulating a high content of fat in a low dosage, comprising the following components by weight percentage:

[0007]

[0008] In a further embodiment, the polyol is selected from one or more of glycerol, 1,3-propylene glycol, butylene glycol, glycerol polyether-26, hexylene glycol, and pentylene glycol.

[0009] In a further embodiment, the oil is selected from one or more of vegetable oils, mineral oils, synthetic oils, semi-synthetic oils, silicone oils, and oil-soluble active ingredients such as retinol and its derivatives, ascorbic acid and its derivatives, tocopherol, and tocopherol acetate.

[0010] In a further embodiment, the thickener is selected from one or more of carbomer, xanthan gum, sodium hyaluronate, sodium acrylate, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, or is not added.

[0011] The water is production water.

[0012] A further solution is that the other substances are selected from one or more of water-soluble active substances, plant extracts, preservatives, flavors, and pH adjusters, or are not added.

[0013] A further embodiment is that the sucrose fatty acid ester emulsifier includes two or more of sucrose stearate, sucrose laurate, sucrose distearate, sucrose dilaurate, sucrose polystearate, sucrose polylaurate, and sucrose palmitate; the sucrose ester emulsifier is sucrose stearate: sucrose distearate = 1-9:9-1; or the mass ratio is 4:1;

[0014] The sucrose ester emulsifier is sucrose stearate:sucrose laurate=1-9:9-1; or a mass ratio of 4:1.

[0015] A further solution is that the method for preparing the above-mentioned emulsifier composition capable of encapsulating a high-content oil at a low dosage comprises the following steps:

[0016] Step 1, select the oil component according to the desired effect, and mix the oil phase by cold or heated;

[0017] Step 2, the sucrose fatty acid ester emulsifier and the polyol are mixed evenly at room temperature, and stirred in a 50-70°C water bath until completely dissolved;

[0018] Step 3, water phase: add water to another container, and add thickener and other ingredients as needed; if necessary, add pH adjuster to adjust the pH value to 5-7.5;

[0019] Step 4, emulsification: add the dispersed sucrose fatty acid ester emulsifier to the water phase under stirring, stir evenly, then add the oil phase and homogenize for 3-5 minutes and stir evenly or slowly add the oil phase under high-speed stirring and stir evenly.

[0020] Another aspect of the present invention provides the use of the above-mentioned emulsifier composition capable of encapsulating a high content of oil at a low dosage in the field of cosmetics and external preparations.

[0021] Another aspect of the present invention provides the use of the emulsifier composition obtained by the above-mentioned preparation method in the field of cosmetics and external preparations.

[0022] The beneficial effects of the present invention are:

[0023] The present invention discloses an emulsifier composition and application that can encapsulate high-content oil with low dosage. Only a low dosage of sucrose fatty acid ester emulsifier is needed to prepare stable creams and lotions, which remain stable under centrifugal test, can reduce the amount of emulsifier and reduce costs; it also shows excellent stability under high temperature conditions, can maintain the stability of creams and lotions, and is of great significance for long-term storage and use of products. The preparation of creams is mild and non-irritating, which can meet the market's high safety requirements. DETAILED DESCRIPTION

[0024] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0025] Example 1

[0026] A method for preparing an emulsifier composition capable of encapsulating a high-content oil at a low dosage comprises the following steps:

[0027] Step 1, selects oil component (squalane 5.0g, isononyl isononanoate 5.0g, vitamin A propionate 0.3g, dimethicone 1.0g, pentaerythritol tetracocoate 0.8g, cetyl ethylhexanoate 5.0g, shea butter 2.0g, vitamin E 0.2g) according to required effect, and mixes oil phase;

[0028] Step 2, sucrose fatty acid ester emulsifier (sucrose stearate 0.08g, sucrose laurate 0.02g) and polyol (glycerol 3.0g, butanediol 3.0g, hexanediol 0.5g, pentanediol 0.5g) were mixed evenly at room temperature, and stirred in a 50-70°C water bath until completely dissolved;

[0029] Step 3, aqueous phase: add water (72.54 g) to another container, and add thickener (Carbopol 9800 0.3 g, xanthan gum 0.2 g), other alternative preservatives (parahydroxyacetophenone 0.5 g), and pH adjuster (sodium hydroxide 0.06 g) as needed to adjust the pH value to 5-7.5;

[0030] Step 4, emulsification: add the dispersed sucrose fatty acid ester emulsifier to the water phase under stirring, stir evenly, then add the oil phase and homogenize for 3-5 minutes and stir evenly or slowly add the oil phase under high-speed stirring and stir evenly.

[0031] According to the method of the present invention, Examples 1-4 and Comparative Examples 1-6 were prepared, and the specific proportions are shown in Table 1 below:

[0032] Table 1 Proportions of the embodiments of the present invention and comparative examples

[0033]

[0034]

[0035] Test 1: Centrifugal stability

[0036] Examples 1-4 and Comparative Examples 1-6 were made into products and tested;

[0037] Centrifugal stability test: Take a certain amount of product, put it into a centrifuge tube, put it into a centrifuge and set it to 4000 rpm for 30 minutes. Then observe the morphology of the product after centrifugation under static conditions, and determine the centrifugal stability of the product based on the results. The specific results are shown in Table 2;

[0038] Table 2 Centrifugal stability test results

[0039] Products Room temperature form After centrifugation, let stand for 5 minutes. Example 1 The material is fine and uniform Same as room temperature Example 2 The material is fine and uniform Same as room temperature Example 3 The material is fine and uniform Same as room temperature Example 4 The material is fine and uniform Same as room temperature Comparative Example 1 Rough material Layering, oil precipitation Comparative Example 2 There are tiny oil droplets on the surface of the material Layering, oil precipitation Comparative Example 3 The material is fine and uniform Layering, oil precipitation Comparative Example 4 Emulsification not completed Layering, water and oil are completely separated Comparative Example 5 Emulsification not completed Layering, water and oil are completely separated Comparative Example 6 The material is fine and uniform Layering, oil precipitation

[0040] In the above examples, stable creams and lotions can be successfully prepared by using only a low dose of sucrose fatty acid ester emulsifier composition. After centrifugation at 4000 rpm for 30 minutes, the example product remained stable without stratification, while the comparative example product using a common emulsifier showed obvious stratification. This result shows that the emulsifier composition of the present invention can achieve an efficient emulsification effect at a low dose, significantly reducing the amount of emulsifier used and reducing production costs.

[0041] Test 2: High temperature, high and low temperature cycle stability

[0042] The products of Examples 1-4 and Comparative Examples 1-6 were made into test bottles of the same material and model, and placed in a circulating constant temperature and humidity chamber (with two temperature parameters of -5°C and 45°C, and the temperature was changed every 24 hours) and a constant temperature and humidity chamber (with a temperature parameter of 50°C). The specific results are shown in Table 3;

[0043] Table 3 High temperature and high and low temperature cycle stability test results

[0044]

[0045] In the above examples, the example products remained stable under high temperature, high and low temperature cycle environment without stratification or deterioration, while the comparative example products stratified. This shows that the emulsifier of the present invention can maintain the stability of creams and lotions under high temperature, high and low temperature cycle conditions.

[0046] Test 3: Safety test

[0047] Examples 1-4 were made into products for skin safety testing; 28 healthy New Zealand white female rabbits (4 rabbits for each example) were selected, with a body weight of 2.132-2.337 kg. Before the test, the animals were kept at a temperature of 16-26°C and a relative humidity of 40-70%.

[0048] Before the test, the animals were adapted to the experimental animal room environment for 3 days. Four rabbits were selected, and the hair on both sides of the back spine was removed. The hair removal area was about 3cm×3cm on each side. After 24 hours of observation, 0.5mL of the original sample was applied to the hair removal area on one side of the undamaged rabbit, and the application area was 2.5cm×2.5cm. The skin of the hair removal area on the other side was used as a control. Examples 1-4 were made into products and applied once a day for 14 consecutive days. Starting from the second day, the hair should be trimmed before each application, and the residual test substance should be removed with warm water. The skin reaction of the application site was observed 1 hour after the test substance was removed. According to the "Technical Specifications for Safety of Cosmetics" (2015 Edition), Chapter 6 4 Skin Irritation / Corrosion Test 5.4.3 Result Evaluation, multiple skin irritation reaction scores were performed, and the erythema and edema of the samples and controls were observed and scored. The mean score of each animal per day was calculated to determine the intensity of skin irritation. The specific results are shown in Table 4;

[0049] Table 4 Results of multiple skin irritation tests on New Zealand white rabbits

[0050]

[0051] As can be seen from Table 4, the mean integral values ​​of each animal per day in the Examples and Comparative Examples were all less than 0.5. According to Chapter 6, 4, Skin Irritation / Corrosion Test, 5.4.3, Results Evaluation, Skin Irritation Intensity Classification of the "Technical Specification for Safety of Cosmetics" (2015 Edition), the products prepared in the Examples are non-irritating, safe, and will not cause skin irritation.

[0052] Test 4: Human skin patch test

[0053] The products prepared in Examples 1-4 were subjected to human safety assessment by patch tests. Ten volunteers aged 20 to 60 years old who met the test requirements were selected as test subjects. A skin closed patch test was conducted. Qualified patch test equipment was selected. By using the closed patch test method, 0.020 to 0.025 ml of the test substance was placed in the patch tester, and a hypoallergenic tape was applied to the curved side of the forearm of the test subject. The test substance was removed after 24 hours. The skin reaction was observed at 0.5, 24, and 48 hours after removal, and the results were recorded according to the skin reaction grading standard in the "Safety Technical Specifications for Cosmetics" (2015 edition). See Table 5.

[0054] Table 5 Skin reaction grading standards for skin occlusive patch test

[0055]

[0056]

[0057] The results of the human skin patch test showed that no adverse skin reactions occurred in 0 of the 10 subjects, which shows that the samples prepared according to Examples 1-4 have no skin irritation, see Table 6.

[0058] Table 6 Summary of skin patch test results

[0059]

[0060] The products of Examples 1-4 passed the 14-day multiple skin irritation test on rabbits and the human skin patch test, which proved that the cream prepared by the emulsifier composition of the present invention is mild and non-irritating and can meet the market demand for high safety.

[0061] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of changes or replacements within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims. It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further explain various possible combinations. In addition, the various different embodiments of the present invention can also be combined arbitrarily, as long as they do not violate the concept of the present invention, they should also be regarded as the contents disclosed by the present invention.

Claims

1. An emulsifier composition capable of encapsulating high-content oil at low dosage, characterized in that: By weight percentage, it includes the following components:

2. The emulsifier composition capable of encapsulating high-content fat at low dosage as claimed in claim 1, characterized in that: The polyol is selected from one or more of glycerol, 1,3-propylene glycol, butylene glycol, glycerol polyether-26, hexylene glycol, and pentylene glycol.

3. The emulsifier composition capable of encapsulating high-content fat at low dosage as claimed in claim 1, characterized in that: The oil is selected from one or more of vegetable oil, mineral oil, synthetic oil, semi-synthetic oil, silicone oil, etc. and oil-soluble active ingredients such as retinol and its derivatives, ascorbic acid and its derivatives, tocopherol, tocopherol acetate, etc.

4. The emulsifier composition capable of encapsulating high-content fat at low dosage as claimed in claim 1, characterized in that: The thickener is selected from one or more of carbomer, xanthan gum, sodium hyaluronate, sodium acrylate, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer or not added; The water is production water.

5. The emulsifier composition capable of encapsulating high-content fat at low dosage as claimed in claim 1, characterized in that: The other substances are selected from one or more of water-soluble active substances, plant extracts, preservatives, flavors, and pH regulators, or are not added.

6. The emulsifier composition capable of encapsulating high-content fat at low dosage as claimed in claim 1, characterized in that: The sucrose fatty acid ester emulsifier includes two or more of sucrose stearate, sucrose laurate, sucrose distearate, sucrose dilaurate, sucrose polystearate, sucrose polylaurate, and sucrose palmitate.

7. The emulsifier composition capable of encapsulating high-content fat at low dosage as claimed in claim 1, characterized in that: The sucrose ester emulsifier is sucrose stearate: sucrose distearate = 1-9:9-1; or a mass ratio of 4:1; The sucrose fatty acid ester emulsifier is sucrose stearate:sucrose laurate=1-9:9-1; or a mass ratio of 4:

1.

8. A method for preparing a low-dosage emulsifier composition capable of encapsulating a high-content oil as claimed in any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1, select the oil component according to the desired effect, and mix the oil phase by cold or heated; Step 2, the sucrose fatty acid ester emulsifier and the polyol are mixed evenly at room temperature, and stirred in a 50-70°C water bath until completely dissolved; Step 3, water phase: add water to another container, and add thickener and other ingredients as needed; if necessary, add pH adjuster to adjust the pH value to 5-7.5; Step 4, emulsification: add the dispersed sucrose fatty acid ester emulsifier to the water phase under stirring, stir evenly, then add the oil phase and homogenize for 3-5 minutes and stir evenly or slowly add the oil phase under high-speed stirring and stir evenly.

9. Use of the emulsifier composition capable of encapsulating high-content oil at a low dosage as claimed in any one of claims 1 to 7 in the field of cosmetics and external preparations.

10. Use of the emulsifier composition obtained by the preparation method according to claim 8 in the field of cosmetics and external preparations.

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