Composition for treating male prostate and improving sexual function and preparation method thereof

Abstract

The invention belongs to the field of medicines, and particularly relates to a composition for treating male prostate and improving sexual function and a preparation method thereof. The composition for treating male prostate and improving sexual function is prepared from the following raw materials in parts by weight: 30 to 33 parts of gynura procumbens extract, 30 to 33 parts of panax japonicus extract, 30 to 33 parts of akebia trifoliate extract, 50 to 55 parts of fructus broussonetiae extract, 30 to 33 parts of raspberry extract and 50 to 55 parts of coffee peptide. The composition provided by the invention is suitable for male population, and can improve energy, effectively treat male prostate and improve sexual function. The raw materials are all natural plant extracts or bioactive peptides, so that the safety is high, and the side effect is small. Through a reasonable preparation process and quality control, the effectiveness and stability of the medicine can be ensured. Clinical test results show that the composition has a good treatment effect and provides a new choice for treating male prostate and improving sexual function.

Description

Technical Field

[0001] The invention belongs to the field of medicine, and in particular relates to a composition for treating male prostate and improving sexual function and a preparation method thereof. Background Art

[0002] With the accelerated pace of modern life and increased pressure, male sexual dysfunction and prostate disease problems are becoming increasingly common, seriously affecting men's quality of life and mental health. Currently, related drugs on the market have problems such as unsatisfactory effects and large side effects. Therefore, it is of great significance to develop a safe and effective drug with no obvious side effects to treat male prostate and improve sexual function.

[0003] Therefore, based on this, the technical solution of the present invention is proposed. Summary of the invention

[0004] In order to solve the problems existing in the prior art, the present invention provides a composition for treating male prostate and improving sexual function and a preparation method thereof, comprising the following raw materials in parts by weight: 30-33 parts of Panax notoginseng extract, 30-33 parts of Panax japonicus extract, 30-33 parts of Akebia trifoliata extract, 50-55 parts of Cucurbita chinensis fruit extract, 30-33 parts of Rubus idaeus extract and 50-55 parts of coffee peptide.

[0005] Preferably, the composition for treating male prostate and improving sexual function comprises the following raw materials in parts by weight: 31.8 parts of Panax notoginseng extract, 31.8 parts of Panax japonicus extract, 31.8 parts of Akebia trifoliata extract, 53 parts of Cucurbita chinensis fruit extract, 31.8 parts of Rubus idaeus extract and 53 parts of coffee peptide.

[0006] For ease of understanding of the present invention, the role of raw materials is described:

[0007] Flat-lying Chrysanthemum Panax Notoginseng: Flat-lying Chrysanthemum Panax Notoginseng belongs to the Asteraceae family, the Panax Notoginseng genus, and is a perennial herb, also known as the life-extending grass and the immortal grass. Its rhizome is an excellent raw material for Chinese patent medicine. It has a sweet and light taste and is flat in nature. It can promote blood circulation, relieve inflammation and cough, disperse blood stasis and reduce swelling, and promote blood circulation and muscle growth. The various active ingredients it contains have the functions of regulating endocrine and improving blood circulation, which helps to improve the congestion capacity of the corpus cavernosum of the penis, thereby enhancing erectile function.

[0008] Bamboo Ginseng: Bamboo Ginseng is a perennial herbaceous plant of the genus Panax in the Araliaceae family. Its taproot is fleshy, cylindrical or spindle-shaped, light yellow in color, and its rhizome is short and obvious. It tastes sweet and slightly bitter, is warm in nature, and enters the liver, spleen, and lung meridians. It has the effects of nourishing and strengthening, and anti-fatigue, can improve the body's immunity and stress resistance, and has a positive effect on improving male sexual function.

[0009] Akebia trifoliata: Akebia trifoliata is a deciduous woody vine plant of the Akebia family. It tastes bitter and is cold in nature. The medicinal part is the vine stem, which is rich in various nutrients and can regulate the function of the nervous system, promote the secretion of sex hormones, and enhance sexual desire.

[0010] Paper mulberry seeds: Paper mulberry seeds are the dried mature fruits of the paper mulberry plant of the Moraceae family. They are harvested when the fruits are ripe in autumn. They need to be washed and dried to remove the grayish white membranous calyx and impurities. They are sweet, cold in nature, non-toxic, and have the effects of nourishing the liver and kidneys, strengthening the waist and knees, and can improve the function of the male reproductive system and improve sperm quality.

[0011] Raspberry: Raspberry is the dried fruit of the Rosaceae plant Raspberry. It tastes sweet, slightly sour, and warm in nature. It enters the liver, kidney, and bladder meridians. Raspberry is rich in vitamins and minerals, such as polysaccharides, glycoproteins, terpenes, salicylic acid, flavonoids, alkaloids, and phenolic acids. It has high nutritional value and has a good regulating effect on the male reproductive system, helping to improve sexual function.

[0012] Coffee peptides: can promote the release of neurotransmitters, enhance nerve conduction, and improve erectile function.

[0013] Preferably, the preparation method of the Panax notoginseng extract is:

[0014] (1) crushing the procumbent chrysanthemum notoginseng, mixing it with an ethanol solution, and performing ultrasonic extraction to obtain an ultrasonic extract;

[0015] (2) filtering, distilling, chromatography, eluting and drying the ultrasonic extract in sequence to obtain a Panax notoginseng extract.

[0016] Preferably, the preparation method of the Panax japonicus extract is:

[0017] (1) crushing Panax notoginseng japonicus, mixing with water, soaking, boiling and extracting to obtain an extract;

[0018] (2) The extract is sequentially centrifuged, concentrated, passed through a macroporous resin column, eluted, and dried to obtain a Panax notoginseng extract.

[0019] Preferably, the preparation method of the Akebia trifoliata extract is:

[0020] (1) crushing Akebia trifoliata and mixing it with an ethanol solution, and performing heating and reflux extraction to obtain an extract;

[0021] (2) filtering, distilling, chromatography, eluting and drying the extract in sequence to obtain the Akebia trifoliata extract.

[0022] Preferably, the preparation method of the paper mulberry seed extract is:

[0023] (1) crushing the seeds of paper mulberry, mixing them with petroleum ether, soaking them and then extracting them to obtain an extract;

[0024] (2) The extract is filtered, distilled, chromatographed, eluted and dried in sequence to obtain a papaya extract.

[0025] Preferably, the preparation method of the raspberry extract is:

[0026] (1) crushing raspberries and mixing with an ethanol solution, and performing ultrasonic extraction to obtain an ultrasonic extract;

[0027] (2) The ultrasonic extract is filtered, distilled, chromatographed, eluted and dried in sequence to obtain a raspberry extract.

[0028] Based on the same technical concept, another embodiment of the present invention is to provide a method for preparing a composition for improving male sexual function and treating prostate, the preparation method comprising the following steps:

[0029] (1) mixing the notoginseng extract, the panax japonicus extract, the akebia trifoliata extract, the cucurbita chinensis fruit extract, and the raspberry extract, grinding and sieving to obtain a premix;

[0030] (2) uniformly mixing the premix and coffee peptide to obtain a mixture;

[0031] (3) The mixture is formulated into an excipient.

[0032] Preferably, in step (3), the dosage form prepared is a pill, tablet or capsule.

[0033] More specifically, the method for preparing the pills is: heat an appropriate amount of adhesive (such as starch slurry, honey, etc.) to an appropriate temperature (such as heating the starch slurry to 60-70° C.), add the mixture, stir evenly to form pellets, and then form them through a pill making machine to obtain pills.

[0034] Pill weight: Each pill weighs about 5g.

[0035] Hardness: The hardness is moderate, which can ensure that the pills are not easily broken during storage and transportation.

[0036] Appearance: Smooth surface and uniform color.

[0037] The preparation method of the tablets is: uniformly mixing the mixture with an appropriate amount of disintegrant (such as sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, etc.) and an appropriate amount of lubricant (such as magnesium stearate, talc, etc.), and pressing the mixture into tablets by a tablet press.

[0038] Tablet weight: Each tablet weighs approximately 0.5g.

[0039] Disintegration time: disintegrates completely within 30 minutes.

[0040] Appearance: Smooth surface and uniform color.

[0041] The preparation method of the capsule is as follows: the mixture is filled into a capsule shell, and a capsule filling machine is used for filling to obtain the capsule.

[0042] Capsule weight: Each capsule weighs approximately 0.4g.

[0043] Contents uniformity: Contents are uniform and consistent.

[0044] It should be noted that the present invention has extremely strict quality control, specifically:

[0045] (i) Raw material quality control: Strict quality testing is performed on raw materials to ensure that the purity and impurity content of the raw materials meet the standards. For example, the moisture content of Panax notoginseng, Panax japonicus, Akebia trifoliata, Cuscuta australis, and Rubus idaeus should be controlled below 5%, and the heavy metal content should meet the relevant standards.

[0046] Moisture content: The moisture content of Panax notoginseng is 4%, the moisture content of Panax japonicus is 3.5%, the moisture content of August fried is 4.2%, the moisture content of Chu Shizi is 4.8%, and the moisture content of raspberry is 4.5%.

[0047] (ii) Finished product quality control: The finished drugs are tested for quality, including appearance, size, weight, dissolution, stability, etc., and all are found to comply with relevant regulations after testing.

[0048] For example, after testing, the tablet weight difference is controlled within ±3%, and the solubility reaches more than 90%; capsules: the capsule weight difference is controlled within ±5%, and the solubility reaches more than 85%.

[0049] The beneficial effects of the present invention are:

[0050] 1. The composition of the present invention is suitable for male population, can improve energy, effectively treat male prostate and improve sexual function. Its raw materials are all natural plant extracts or bioactive peptides, with high safety and small side effects. Through reasonable preparation process and quality control, the effectiveness and stability of the drug can be ensured. Clinical trial results show that the composition has a good therapeutic effect and provides a new option for treating male prostate and improving sexual function.

[0051] 2. The preparation method of the present invention is simple and easy to control, which is conducive to large-scale output. DETAILED DESCRIPTION

[0052] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0053] Example 1

[0054] This embodiment provides a method for preparing a composition for treating male prostate and improving sexual function, the preparation method comprising the following steps:

[0055] (I) Preparation of Panax notoginseng extract:

[0056] (I-1) crushing the procumbent chrysanthemum Panax notoginseng, placing it in an extraction container, adding 70 vol% ethanol solution, performing ultrasonic extraction at a temperature of 60° C., an ultrasonic frequency of 40 kHz, and an extraction time of 2 hours, to obtain an ultrasonic extract;

[0057] (I-2) After the extract is filtered, ethanol is recovered by vacuum distillation to obtain a crude extract, and the crude extract is purified by column chromatography using a silica gel column as the stationary phase and chloroform-methanol (volume ratio of 8:2) as the eluent. The eluate is collected and dried to obtain a Panax notoginseng extract.

[0058] Extraction rate: about 8% (i.e. 8g of extract can be extracted from every 100g of raw material).

[0059] Purity: After purification, the purity can reach 95%.

[0060] (II) Preparation of Panax notoginseng extract:

[0061] (II-1) First, crush the Panax notoginseng, add 8 times the amount of water, soak for 2 hours, heat to boiling, and keep it in a slightly boiling state for 3 hours to obtain an extract;

[0062] (II-2) The extract is cooled and centrifuged, and the supernatant is collected and concentrated and dried to obtain a crude extract. The crude extract aqueous solution is then passed through a macroporous resin column and eluted with water and ethanol in sequence. The eluate is collected and dried to obtain a Panax notoginseng extract.

[0063] Extraction rate: about 10% (i.e. 10g of extract can be extracted from every 100g of raw material).

[0064] Purity: After purification, the purity can reach 92%.

[0065] (III) Preparation of Akebia trifoliata extract:

[0066] (III-1) After chopping Akebia trifoliata, adding 10 times the amount of ethanol solution, performing reflux extraction at a temperature of 50° C. for 4 hours to obtain an extract;

[0067] (III-2) After filtering the extract, the ethanol was recovered by distillation under reduced pressure to obtain a crude extract, which was then purified by normal phase silica gel column chromatography using petroleum ether-ethyl acetate (volume ratio of 6:4) as eluent, and the eluate was collected and dried to obtain a trifoliate akebia extract.

[0068] Extraction rate: about 12% (i.e. 12g of extract can be extracted from every 100g of raw material).

[0069] Purity: After purification, the purity can reach 90%.

[0070] (IV) Preparation of Paper Mulberry Fruit Extract:

[0071] (IV-1) After crushing the paper mulberry seeds, adding 5 times the amount of petroleum ether, soaking at room temperature for 24 hours, and then extracting to obtain an extract;

[0072] (IV-2) After filtering the extract, the petroleum ether is recovered by vacuum distillation to obtain a crude extract, and the crude extract is then purified by reverse phase silica gel column chromatography using methanol-water (volume ratio of 7:3) as eluent, and the eluate is collected and dried to obtain the paper mulberry seed extract.

[0073] Extraction rate: about 6% (i.e. 6g of extract can be extracted from every 100g of raw material).

[0074] Purity: After purification, the purity can reach 93%.

[0075] (V) Preparation of raspberry extract:

[0076] (V-1) After crushing raspberries, add 6 times the amount of ethanol solution, perform ultrasonic extraction at a temperature of 40° C., an ultrasonic frequency of 30 kHz, and an extraction time of 3 hours to obtain an ultrasonic extract;

[0077] (V-2) After filtering the extract, the ethanol is recovered by distillation under reduced pressure to obtain a crude extract, which is then purified by polyamide column chromatography using ethanol-water (volume ratio of 4:6) as an eluent, and the eluate is collected and dried to obtain a raspberry extract.

[0078] Extraction rate: about 9% (i.e. 9g of extract can be extracted from every 100g of raw material).

[0079] Purity: After purification, the purity can reach 94%.

[0080] (VI) Preparation of pill composition:

[0081] (VI-1) 30 g of Panax notoginseng extract, 30 g of Panax japonicus extract, 30 g of Akebia trifoliata extract, 50 g of Cucurbita chinensis fruit extract, and 30 g of Rubus idaeus extract were mixed, ground, and sieved to obtain a premix;

[0082] (VI-2) mixing the premix with 50 g of coffee peptide to obtain a mixture;

[0083] (VI-3) Heat an appropriate amount of starch slurry adhesive to 60° C., add the mixture, stir evenly to form pellets, and then use a pelletizing machine to shape the pellets to obtain pills.

[0084] Example 2

[0085] This embodiment provides a method for preparing a composition for treating male prostate and improving sexual function, the preparation method comprising the following steps:

[0086] (I) Preparation of Panax notoginseng extract:

[0087] (I-1) crushing the procumbent chrysanthemum Panax notoginseng, placing it in an extraction container, adding 75 vol% ethanol solution, performing ultrasonic extraction at a temperature of 65° C., an ultrasonic frequency of 45 kHz, and an extraction time of 1.5 hours, and obtaining an ultrasonic extract after completion;

[0088] (I-2) After the extract is filtered, ethanol is recovered by vacuum distillation to obtain a crude extract, and the crude extract is purified by column chromatography using a silica gel column as the stationary phase and chloroform-methanol (volume ratio of 8:2) as the eluent. The eluate is collected and dried to obtain a Panax notoginseng extract.

[0089] Extraction rate: about 8% (i.e. 8g of extract can be extracted from every 100g of raw material).

[0090] Purity: After purification, the purity can reach 95%.

[0091] (II) Preparation of Panax notoginseng extract:

[0092] (II-1) First, crush the Panax notoginseng, add 10 times the amount of water, soak for 3 hours, heat to boiling, and maintain the slightly boiling state for 4 hours to obtain an extract;

[0093] (II-2) The extract is cooled and centrifuged, and the supernatant is collected and concentrated and dried to obtain a crude extract. The crude extract aqueous solution is then passed through a macroporous resin column and eluted with water and ethanol in sequence. The eluate is collected and dried to obtain a Panax notoginseng extract.

[0094] Extraction rate: about 10% (i.e. 10g of extract can be extracted from every 100g of raw material).

[0095] Purity: After purification, the purity can reach 92%.

[0096] (III) Preparation of Akebia trifoliata extract:

[0097] (III-1) After chopping Akebia trifoliata, adding 8 times the amount of ethanol solution, performing reflux extraction at a temperature of 55° C. for 5 hours to obtain an extract;

[0098] (III-2) After filtering the extract, the ethanol was recovered by distillation under reduced pressure to obtain a crude extract, which was then purified by normal phase silica gel column chromatography using petroleum ether-ethyl acetate (volume ratio of 6:4) as eluent, and the eluate was collected and dried to obtain a trifoliate akebia extract.

[0099] Extraction rate: about 12% (i.e. 12g of extract can be extracted from every 100g of raw material).

[0100] Purity: After purification, the purity can reach 90%.

[0101] (IV) Preparation of Paper Mulberry Fruit Extract:

[0102] (IV-1) After crushing the paper mulberry seeds, add 6 times the amount of petroleum ether, soak at room temperature for 28 hours, and then extract to obtain an extract;

[0103] (IV-2) After filtering the extract, the petroleum ether is recovered by vacuum distillation to obtain a crude extract, and the crude extract is then purified by reverse phase silica gel column chromatography using methanol-water (volume ratio of 7:3) as eluent, and the eluate is collected and dried to obtain the paper mulberry seed extract.

[0104] Extraction rate: about 6% (i.e. 6g of extract can be extracted from every 100g of raw material).

[0105] Purity: After purification, the purity can reach 93%.

[0106] (V) Preparation of raspberry extract:

[0107] (V-1) After crushing raspberries, add 7 times the amount of ethanol solution, perform ultrasonic extraction at a temperature of 45° C., an ultrasonic frequency of 35 kHz, and an extraction time of 4 hours to obtain an ultrasonic extract;

[0108] (V-2) After filtering the extract, the ethanol is recovered by distillation under reduced pressure to obtain a crude extract, which is then purified by polyamide column chromatography using ethanol-water (volume ratio of 4:6) as an eluent, and the eluate is collected and dried to obtain a raspberry extract.

[0109] Extraction rate: about 9% (i.e. 9g of extract can be extracted from every 100g of raw material).

[0110] Purity: After purification, the purity can reach 94%.

[0111] (VI) Preparation of tablet composition:

[0112] (VI-1) 33 g of Panax notoginseng extract, 33 g of Panax japonicus extract, 33 g of Akebia trifoliata extract, 55 g of Cucurbita chinensis fruit extract, and 33 g of Rubus idaeus extract were mixed, ground, and sieved to obtain a premix;

[0113] (VI-2) mixing the premix with 55 g of coffee peptide to obtain a mixture;

[0114] (VI-3) The mixture is mixed evenly with a disintegrant (sodium carboxymethyl starch) and a lubricant (magnesium stearate), and the mixture is pressed into tablets using a tablet press.

[0115] Example 3

[0116] This embodiment provides a method for preparing a composition for treating male prostate and improving sexual function, the preparation method comprising the following steps:

[0117] (I) Preparation of Panax notoginseng extract:

[0118] (I-1) crushing the flat chrysanthemum Panax notoginseng, placing it in an extraction container, adding 72 vol% ethanol solution, performing ultrasonic extraction at a temperature of 43° C., an ultrasonic frequency of 38 kHz, and an extraction time of 3 hours, and obtaining an ultrasonic extract after completion;

[0119] (I-2) After the extract is filtered, ethanol is recovered by vacuum distillation to obtain a crude extract, and the crude extract is purified by column chromatography using a silica gel column as the stationary phase and chloroform-methanol (volume ratio of 8:2) as the eluent. The eluate is collected and dried to obtain a Panax notoginseng extract.

[0120] Extraction rate: about 8% (i.e. 8g of extract can be extracted from every 100g of raw material).

[0121] Purity: After purification, the purity can reach 95%.

[0122] (II) Preparation of Panax notoginseng extract:

[0123] (II-1) First, crush the Panax notoginseng, add 6 times the amount of water, soak for 3 hours, heat to boiling, and keep it in a slightly boiling state for 2 hours to obtain an extract;

[0124] (II-2) The extract is cooled and centrifuged, and the supernatant is collected and concentrated and dried to obtain a crude extract. The crude extract aqueous solution is then passed through a macroporous resin column and eluted with water and ethanol in sequence. The eluate is collected and dried to obtain a Panax notoginseng extract.

[0125] Extraction rate: about 10% (i.e. 10g of extract can be extracted from every 100g of raw material).

[0126] Purity: After purification, the purity can reach 92%.

[0127] (III) Preparation of Akebia trifoliata extract:

[0128] (III-1) After chopping Akebia trifoliata, adding 9 times the amount of ethanol solution, performing reflux extraction at a temperature of 47° C. for 3 hours to obtain an extract;

[0129] (III-2) After filtering the extract, the ethanol was recovered by distillation under reduced pressure to obtain a crude extract, which was then purified by normal phase silica gel column chromatography using petroleum ether-ethyl acetate (volume ratio of 6:4) as eluent, and the eluate was collected and dried to obtain a trifoliate akebia extract.

[0130] Extraction rate: about 12% (i.e. 12g of extract can be extracted from every 100g of raw material).

[0131] Purity: After purification, the purity can reach 90%.

[0132] (IV) Preparation of Paper Mulberry Fruit Extract:

[0133] (IV-1) After crushing the paper mulberry seeds, adding 4.5 times the amount of petroleum ether, soaking at room temperature for 25 hours, and then extracting to obtain an extract;

[0134] (IV-2) After filtering the extract, the petroleum ether is recovered by vacuum distillation to obtain a crude extract, and the crude extract is then purified by reverse phase silica gel column chromatography using methanol-water (volume ratio of 7:3) as eluent, and the eluate is collected and dried to obtain the paper mulberry seed extract.

[0135] Extraction rate: about 6% (i.e. 6g of extract can be extracted from every 100g of raw material).

[0136] Purity: After purification, the purity can reach 93%.

[0137] (V) Preparation of raspberry extract:

[0138] (V-1) After crushing raspberries, add 5.5 times the amount of ethanol solution, perform ultrasonic extraction at a temperature of 43° C., an ultrasonic frequency of 30 kHz, and an extraction time of 3 hours to obtain an ultrasonic extract;

[0139] (V-2) After filtering the extract, the ethanol is recovered by distillation under reduced pressure to obtain a crude extract, which is then purified by polyamide column chromatography using ethanol-water (volume ratio of 4:6) as an eluent, and the eluate is collected and dried to obtain a raspberry extract.

[0140] Extraction rate: about 9% (i.e. 9g of extract can be extracted from every 100g of raw material).

[0141] Purity: After purification, the purity can reach 94%.

[0142] (VI) Preparation of capsule composition:

[0143] (VI-1) 31.8 g of Panax notoginseng extract, 31.8 g of Panax japonicus extract, 31.8 g of Akebia trifoliata extract, 53 g of Cucurbita chinensis fruit extract, and 31.8 g of Rubus idaeus extract were mixed, ground, and sieved to obtain a premix;

[0144] (VI-2) mixing the premix with 53 g of coffee peptide to obtain a mixture;

[0145] (VI-3) The mixture is filled into capsule shells and filled using a capsule filling machine to obtain capsules.

[0146] Verification Example

[0147] Experimental subjects: A total of 200 male patients with sexual dysfunction and prostate diseases aged between 30 and 60 years old were selected.

[0148] Test method: The patients were randomly divided into two groups, each with 100 cases. One group took the composition prepared by the present invention (Example 1), and the other group took a placebo. The test period was 3 months, during which the improvement of the patients' sexual function, the occurrence of adverse reactions, etc. were recorded.

[0149] Sexual function indicators: including erectile function, sexual desire, sexual satisfaction, etc.

[0150] Erectile function: The International Index of Erectile Function (IIEF) was used to evaluate the patients' erectile function. The average score was 30 before taking the medication and 45 after taking the medication.

[0151] Sexual desire: As assessed by questionnaire, the average sexual desire score before taking the drug was 4 points, and the average score after taking the drug was 6 points.

[0152] Sexual life satisfaction: The sexual life satisfaction scale was used to evaluate the condition. The average score was 6 before taking the medication and 8 after taking the medication.

[0153] Adverse reactions: Record adverse reactions experienced by patients during the trial, such as gastrointestinal discomfort, dizziness, headache, etc.

[0154] Drug group: The incidence of adverse reactions was 10%, mainly manifested as mild gastrointestinal discomfort, such as nausea, vomiting, etc., and the symptoms disappeared after treatment.

[0155] Placebo group: The incidence of adverse reactions was 5%, mainly manifested as dizziness, headache, etc.

[0156] Test results: The patients taking the drug of the present invention were significantly better than those taking the placebo in terms of improvement in sexual function, including significant improvement in erectile function, sexual desire, and sexual life satisfaction, with a total effective rate of 80%.

[0157] Typical Cases

[0158] Case 1

[0159] Patient's basic information: Mr. Li, 45 years old, has suffered from prostate disease for many years and has tried many treatments with poor results.

[0160] Treatment process: Mr. Li took the composition prepared by the present invention (Example 1) 3 times a day, 3 pills each time. After taking it for 1 month, he gradually felt that his erectile function was improved and his sexual desire was enhanced.

[0161] Effect: After 3 months of treatment, Mr. Li's erectile function was significantly improved and his sexual satisfaction was improved. His IIEF score increased from 32 points before treatment to 48 points, and his sexual desire score increased from 4 points to 6 points.

[0162] Adverse reactions: During the treatment, Mr. Li experienced mild gastrointestinal discomfort, such as nausea and vomiting, which disappeared after the dosage was adjusted.

[0163] Case 2

[0164] Basic information of the patient: Mr. Zhang, 38 years old, suffered from sexual dysfunction and decreased erectile function due to work pressure.

[0165] Treatment process: Mr. Zhang took the tablets prepared by the present invention twice a day, 2 tablets each time. After taking it for 2 months, his erectile function gradually recovered and his sexual desire improved.

[0166] Effect: After 3 months of treatment, Mr. Zhang's erectile function has been significantly improved, and his sexual satisfaction has increased. His IIEF score has increased from 28 points before treatment to 42 points, and his sexual desire score has increased from 3 points to 5 points.

[0167] Adverse reactions: None.

[0168] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A composition for treating male prostate and improving sexual function, characterized in that: The invention comprises the following raw materials in parts by weight: 30-33 parts of Panax notoginseng extract, 30-33 parts of Panax japonicus extract, 30-33 parts of Akebia trifoliata extract, 50-55 parts of Cucurbita chinensis fruit extract, 30-33 parts of Rubus idaeus extract and 50-55 parts of coffee peptide.

2. The composition for treating male prostate and improving sexual function according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 31.8 parts of Panax notoginseng extract, 31.8 parts of Panax japonicus extract, 31.8 parts of Akebia trifoliata extract, 53 parts of Cucurbita chinensis fruit extract, 31.8 parts of Rubus idaeus extract and 53 parts of coffee peptide.

3. The composition for treating male prostate and improving sexual function according to claim 1 or 2, characterized in that: The preparation method of the flat chrysanthemum Panax notoginseng extract is: (1) crushing the procumbent chrysanthemum notoginseng, mixing it with an ethanol solution, and performing ultrasonic extraction to obtain an ultrasonic extract; (2) filtering, distilling, chromatography, eluting and drying the ultrasonic extract in sequence to obtain a Panax notoginseng extract.

4. The composition for treating male prostate and improving sexual function according to claim 1 or 2, characterized in that: The preparation method of the Panax japonicus extract is as follows: (1) crushing Panax notoginseng japonicus, mixing with water, soaking, boiling and extracting to obtain an extract; (2) The extract is sequentially centrifuged, concentrated, passed through a macroporous resin column, eluted, and dried to obtain a Panax notoginseng extract.

5. The composition for treating male prostate and improving sexual function according to claim 1 or 2, characterized in that: The preparation method of the Akebia trifoliata extract is as follows: (1) crushing Akebia trifoliata and mixing it with an ethanol solution, and performing heating and reflux extraction to obtain an extract; (2) filtering, distilling, chromatography, eluting and drying the extract in sequence to obtain the Akebia trifoliata extract.

6. The composition for treating male prostate and improving sexual function according to claim 1 or 2, characterized in that: The preparation method of the paper mulberry seed extract is as follows: (1) crushing the seeds of paper mulberry, mixing them with petroleum ether, soaking them and then extracting them to obtain an extract; (2) The extract is filtered, distilled, chromatographed, eluted and dried in sequence to obtain a papaya extract.

7. The composition for treating male prostate and improving sexual function according to claim 1 or 2, characterized in that: The preparation method of the raspberry extract is: (1) crushing raspberries and mixing with an ethanol solution, and performing ultrasonic extraction to obtain an ultrasonic extract; (2) The ultrasonic extract is filtered, distilled, chromatographed, eluted and dried in sequence to obtain a raspberry extract.

8. The method for preparing the composition for treating male prostate and improving sexual function according to any one of claims 1 to 7, characterized in that: The preparation method comprises the following steps: (1) mixing the notoginseng extract, the panax japonicus extract, the akebia trifoliata extract, the cucurbita chinensis fruit extract, and the raspberry extract, grinding and sieving to obtain a premix; (2) uniformly mixing the premix and coffee peptide to obtain a mixture; (3) The mixture is formulated into an excipient.

9. The preparation method according to claim 8, characterized in that: In step (3), the dosage form prepared is pills, tablets or capsules.