Active material repair patch and preparation method thereof

Abstract

The invention provides an active material repairing patch which comprises non-woven fabric and release paper, the release paper is formed on the lower end face of the non-woven fabric, a wrapping bag is arranged between the non-woven fabric and the release paper, the wrapping bag specifically comprises two sets of wrapping films with the peripheries sealed, a first air bag and a second air bag are arranged in the wrapping bag, and the first air bag and the second air bag are arranged in the non-woven fabric. The non-woven fabric is attached to the affected part, then the repair patch is pressed, the soluble microneedles pierce the wrapping film located on the lower layer, the non-woven fabric is attached to the affected part, the non-woven fabric is attached to the affected part, the soluble microneedles penetrate through the wrapping film located on the lower layer, the non-woven fabric is attached to the affected part, the non-woven fabric is attached to the affected part, and the non-woven fabric and the release paper are attached to the other side of the wrapping film adjacent to the non-woven fabric. The active repair material can be applied to the affected part through the puncture holes, due to the fact that the repair material has certain viscidity, gas in the air bag can be accumulated around the applied affected part after being exhausted through the puncture holes, and the problem that the periphery of the affected part is pulled when the repair patch is torn off during dressing change due to the fact that non-woven fabric is pasted around the affected part, and pain of a patient is caused is solved.

Description

Technical Field

[0001] The invention relates to the technical field of wound repair, in particular to an active material repair patch and a preparation method thereof. Background Art

[0002] In daily life, people are prone to accidentally causing epidermal trauma in a variety of scenarios. In order to prevent wound infection, dressings are often used to cover the wound to form a protective layer on the wound surface, which serves as a physical barrier to prevent scarring and promote wound healing. Currently, the dressings used for wound repair on the market are mainly divided into gel dressings, liquid dressings, non-woven dressings and spray dressings.

[0003] For some shallow wounds or wounds that are treated at home after being treated in the hospital, the existing repair patches are generally treated by the patients themselves at home. The repair patches are pasted around the wounds. In the later stage of wound healing, when the patients can move freely, the movement will cause the patch to deform due to adhesion to the skin of the affected area, leading to deformation of the affected area, causing pain to the patients. In addition, when changing the dressing, the repair patch is pasted around the affected area for a long time, causing obvious pain to the patients during the dressing change. When using the existing patches, the effective substances can only be released by manual extrusion, which will bring discomfort to the patients. In addition, the uniformity of the manual extrusion method is poor and cannot meet the use requirements. Summary of the invention

[0004] 1. Technical issues to be resolved In view of the deficiencies of the prior art, the present invention provides an active material repair patch and a preparation method thereof to solve the problems raised in the above background technology.

[0005] (II) Technical solution To achieve the above objectives, the present invention is implemented through the following technical solutions: an active material repair patch, comprising a non-woven fabric and a release paper, wherein the release paper is formed on the lower end surface of the non-woven fabric, a wrapping bag is arranged between the non-woven fabric and the release paper, and the wrapping bag is specifically two groups of wrapping films sealed on all sides, and an air bag 1 and an air bag 2 are arranged inside the wrapping bag, and two groups of soluble microneedles are arranged on the other side of the wrapping film adjacent to the non-woven fabric, and an active repair material is applied to the corresponding position of the wrapping film adjacent to the release paper, and the active repair material corresponds to the position of a group of soluble microneedles, and a pressing part is arranged on the side of the non-woven fabric away from the release paper, and the pressing part includes an elastic layer and a balancing part, and the midline of the elastic layer coincides with the midline of the non-woven fabric; The active repair material is prepared from the following raw materials in parts by weight: Sodium hyaluronate 0.1-40%; Active minerals 2-50%; Medical vaseline 50-90%; The remainder is auxiliary materials; The active mineral is specifically any one or more of bioactive glass, tricalcium phosphate and hydroxyapatite.

[0006] Preferably, it is made of the following raw materials in parts by weight: 5% sodium hyaluronate; 90% active minerals; and the remainder are auxiliary materials.

[0007] Preferably, the active repair material is made of the following raw materials in parts by weight: 2% sodium hyaluronate; 25% active minerals; 60% medical vaseline; and the remainder is auxiliary materials.

[0008] Preferably, the active repair material is made of the following raw materials in parts by weight: 1% sodium hyaluronate; 22% active minerals; 70% medical vaseline; and the remainder is auxiliary materials.

[0009] Preferably, the active repair material is made of the following raw materials in parts by weight: 25% sodium hyaluronate; 25% active minerals; 49% medical vaseline; and the remainder is auxiliary materials.

[0010] Preferably, the active repair material is made of the following raw materials in parts by weight: 25% sodium hyaluronate; 30% active minerals; 44% medical vaseline; and the remainder is auxiliary materials.

[0011] Preferably, the active repair material is made of the following raw materials in parts by weight: 20% sodium hyaluronate; 32% active minerals; 47% medical vaseline; and the remainder is auxiliary materials.

[0012] Preferably, the active repair material is made of the following raw materials in parts by weight: 35% sodium hyaluronate; 20% active minerals; 44% medical vaseline; and the remainder is auxiliary materials.

[0013] Preferably, the active repair material is made of the following raw materials in parts by weight: 36% sodium hyaluronate; 38% active minerals; 25.5% medical vaseline; and the remainder is auxiliary materials.

[0014] Preferably, the second air bag surrounds the first air bag inside, and the second air bag corresponds to the position of another group of soluble microneedles.

[0015] Preferably, the side of the air bag of the active repair material facing away from the non-woven fabric is flat.

[0016] The raw materials of the bioactive glass described in the active repair material are composed according to the following weight ratios: Silicon dioxide 20-60%; Sodium oxide 0-30%; Calcium oxide 8-45%; Phosphorus pentoxide 2-20%; Calcium fluoride 0-5%; Boron oxide 0-20%; Zinc oxide 0-5%; Copper oxide 0-5%; Potassium oxide 0-5%; Magnesium oxide 0-5%.

[0017] Preferably, the raw materials of the bioactive glass are composed in the following weight ratios: 34.2% silicon dioxide; 0% sodium oxide; 44.9% calcium oxide; 16.3% phosphorus pentoxide; 0.5% calcium fluoride; 0% boron oxide; 0% zinc oxide; 0% copper oxide; 0% potassium oxide; and 4.6% magnesium oxide.

[0018] Preferably, the raw materials of the bioactive glass are composed in the following weight ratios: 15% silicon dioxide; 15% sodium oxide; 27% calcium oxide; 8% phosphorus pentoxide; 5% calcium fluoride; 10% boron oxide; 5% zinc oxide; 5% copper oxide; 5% potassium oxide; and 5% magnesium oxide.

[0019] Preferably, the raw materials of the bioactive glass are composed in the following weight ratios: 10% silicon dioxide; 20% sodium oxide; 18% calcium oxide; 12% phosphorus pentoxide; 4% calcium fluoride; 20% boron oxide; 4% zinc oxide; 4% copper oxide; 4% potassium oxide; and 4% magnesium oxide.

[0020] Preferably, the raw materials of the bioactive glass are composed in the following weight ratios: 15% silicon dioxide; 15% sodium oxide; 32% calcium oxide; 8% phosphorus pentoxide; 3% calcium fluoride; 15% boron oxide; 3% zinc oxide; 3% copper oxide; 3% potassium oxide; and 3% magnesium oxide.

[0021] Preferably, the raw materials of the bioactive glass are composed in the following weight ratios: 40% silicon dioxide; 20% sodium oxide; 22% calcium oxide; 8% phosphorus pentoxide; 1% calcium fluoride; 5% boron oxide; 1% zinc oxide; 1% copper oxide; 1% potassium oxide; and 1% magnesium oxide.

[0022] Preferably, the auxiliary material is one or more of glycerol, liquid paraffin, PEG, sodium carboxymethyl cellulose, a thickener, and a surfactant.

[0023] Preferably, the height of the soluble microneedle is 900 um, the bottom radius is 180 um, the tip radius is 10 um, and the thickness of the wrapping film is 300-500 um.

[0024] Preferably, both ends of the elastic layer are fixedly connected with an adhesive layer.

[0025] Preferably, two groups of the balancing parts are provided, the balancing parts are fixedly connected to the non-woven fabric, and the edges of the balancing parts are aligned with an inner edge of the air bag.

[0026] Preferably, a method for preparing an active material repair patch comprises the following steps: S1: Take the raw materials of the repair material according to the components; S2: Mixing and preparing active minerals according to raw materials; S3: an active repair material prepared by mixing the active minerals of S2 with sodium hyaluronate, medical vaseline, etc. according to the above proportions; S4: Disposing soluble microneedles on the surface of one set of wrapping films, and coating an appropriate amount of active repair material on the corresponding positions of another set of wrapping films; S5: aligning the two sets of wrapping films, firstly heat-pressing and sealing the edges of the two sets of wrapping films to form a wrapping bag, wherein the interior of the wrapping bag is filled with nitrogen, and then heat-pressing is performed to form two sets of air bags; S6: bonding the wrapping bag to the lower end surface of the non-woven fabric, and then covering the air bag with release paper to form a primary repair patch; S7: Bond the balancing part to the rear of the initial repair patch and leave a gap, bond the middle of the elastic band to the reserved gap to obtain the repair patch.

[0027] Preferably, the preparation process of the bioactive glass from the active mineral raw materials is as follows: after the bioactive glass raw materials are mixed in proportion, the bioactive glass is prepared by a sol-gel method or a hot melt / melting method, and after aging, drying, and crushing, the finished product is obtained by passing through a 50-mesh sieve.

[0028] (III) Beneficial effects The present invention provides an active material repair patch and a preparation method thereof, which have the following beneficial effects: The present invention is to stick the non-woven fabric on the affected part, and then press the repair patch, pierce the wrapping film on the lower layer through the soluble microneedle, and the active repair material is applied to the affected part through the puncture hole. Since the repair material has a certain viscosity, the gas inside the air bag is released through the puncture hole and then accumulates around the affected part, preventing the non-woven fabric from sticking to the affected part, which causes the area around the affected part to be pulled when the repair patch is torn off for dressing change, causing pain to the patient. At the same time, by providing a pressing part, the adhesive part can enhance the adhesive effect of the repair patch, and under the action of the adhesive part, the pressing part will form a U-shape, thereby The elastic layer will press the balancing part, so that the soluble microneedles will pierce the wrapping film. The balancing part will evenly apply the pressure of the elastic layer to the repair material, so that the repair material will be squeezed out. At the same time, as the wound continues to heal and the repair material is consumed, the elastic layer will restore its deformation, keeping the repair material under a certain pressure at all times, thereby ensuring that the repair material is continuously squeezed out, so that a piece of repair patch can be used to maintain the wound until it is healed. Under the action of the balancing part, the repair material can be ensured to be in a state of continuous extrusion, and as the wound heals and the active material is consumed, the amount of repair material extruded can be gradually reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a schematic diagram of the repair patch structure of the present invention; Figure 2 It is a schematic diagram of the upper structure of the nonwoven fabric of the present invention; Figure 3 It is a schematic diagram of the cross-sectional structure of the wrapping bag of the present invention; Figure 4 This is a real picture of the back of the repair patch of the present invention; Figure 5 It is a schematic diagram of the pressing part of the repair patch of the present invention; Figure 6 This is a physical picture of the repair material of the present invention; Figure 7 This is a real-life picture of the repair patch of the present invention.

[0030] The meanings of the numbers in the figure are: 100 release paper, 200 non-woven fabric, 300 wrapping bag, 400 active repair material, 500 air bag one, 600 air bag two, 700 soluble microneedle, 800 elastic layer, 801 bonding part, and 900 balancing part. DETAILED DESCRIPTION

[0031] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0032] The disclosure below provides many different embodiments or examples to implement different structures of the present invention. In order to simplify the disclosure of the present invention, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present invention. In addition, the present invention can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplicity and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the present invention provides various specific examples of processes and materials, but those of ordinary skill in the art can appreciate the application of other processes and / or the use of other materials.

[0033] In one aspect, the present invention provides a wound surface active repair material 400, which is prepared from the following raw materials in parts by weight: Sodium hyaluronate 0.1-40%; Active minerals 2-50%; Medical vaseline 50-90%; The remainder is auxiliary materials; The active mineral is specifically any one or more of bioactive glass, tricalcium phosphate and hydroxyapatite.

[0034] The repair material provided by the present invention is made of the following raw materials in parts by weight: 5% sodium hyaluronate; 90% active minerals; and the remainder is auxiliary materials.

[0035] The repair material provided by the present invention is made of the following raw materials in parts by weight: 2% sodium hyaluronate; 25% active minerals; 60% medical vaseline; and the remainder is auxiliary materials.

[0036] The repair material provided by the present invention is made of the following raw materials in parts by weight: 1% sodium hyaluronate; 22% active minerals; 70% medical vaseline; and the remainder is auxiliary materials.

[0037] The repair material provided by the present invention is made of the following raw materials in parts by weight: 25% sodium hyaluronate; 25% active minerals; 49% medical vaseline; and the remainder is auxiliary materials.

[0038] The repair material provided by the present invention is made of the following raw materials in parts by weight: 25% sodium hyaluronate; 30% active minerals; 44% medical vaseline; and the remainder is auxiliary materials.

[0039] The repair material provided by the present invention is made of the following raw materials in parts by weight: 20% sodium hyaluronate; 32% active minerals; 47% medical vaseline; and the remainder is auxiliary materials.

[0040] The repair material provided by the present invention is made of the following raw materials in parts by weight: 35% sodium hyaluronate; 20% active minerals; 44% medical vaseline; and the remainder is auxiliary materials.

[0041] The repair material provided by the present invention is made of the following raw materials in parts by weight: 36% sodium hyaluronate; 38% active minerals; 25.5% medical vaseline; and the remainder is auxiliary materials.

[0042] Furthermore, the raw materials of the bioactive glass are composed according to the following weight ratios: Silicon dioxide 20-60%; Sodium oxide 0-30%; Calcium oxide 8-45%; Phosphorus pentoxide 2-20%.

[0043] Calcium fluoride 1-5%; Boron oxide 1-20%; Zinc oxide 1-5%; Copper oxide 1-5%; Potassium oxide 1-5%; Magnesium oxide 1-5%.

[0044] In some preferred embodiments of the embodiments of the present invention, the raw materials of the bioactive glass are composed in the following weight ratios: 34.2% silicon dioxide; 0% sodium oxide; 44.9% calcium oxide; 16.3% phosphorus pentoxide; 0.5% calcium fluoride; 0% boron oxide; 0% zinc oxide; 0% copper oxide; 0% potassium oxide; and 4.6% magnesium oxide.

[0045] In some preferred embodiments of the embodiments of the present invention, the raw materials of the bioactive glass are composed in the following weight ratios: 15% silicon dioxide; 15% sodium oxide; 27% calcium oxide; 8% phosphorus pentoxide; 5% calcium fluoride; 10% boron oxide; 5% zinc oxide; 5% copper oxide; 5% potassium oxide; and 5% magnesium oxide.

[0046] In some preferred embodiments of the embodiments of the present invention, the raw materials of the bioactive glass are composed in the following weight ratios: 10% silicon dioxide; 20% sodium oxide; 18% calcium oxide; 12% phosphorus pentoxide; 4% calcium fluoride; 20% boron oxide; 4% zinc oxide; 4% copper oxide; 4% potassium oxide; and 4% magnesium oxide.

[0047] In some preferred embodiments of the embodiments of the present invention, the raw materials of the bioactive glass are composed in the following weight ratios: 15% silicon dioxide; 15% sodium oxide; 32% calcium oxide; 8% phosphorus pentoxide; 3% calcium fluoride; 15% boron oxide; 3% zinc oxide; 3% copper oxide; 3% potassium oxide; and 3% magnesium oxide.

[0048] In some preferred embodiments of the embodiments of the present invention, the raw materials of the bioactive glass are composed in the following weight ratios: 40% silicon dioxide; 20% sodium oxide; 22% calcium oxide; 8% phosphorus pentoxide; 1% calcium fluoride; 5% boron oxide; 1% zinc oxide; 1% copper oxide; 1% potassium oxide; and 1% magnesium oxide.

[0049] Furthermore, the auxiliary material is specifically one or more of glycerol, liquid paraffin, PEG, sodium carboxymethyl cellulose, a thickener, and a surfactant.

[0050] On the other hand, the present invention provides an active material repair patch, which uses the above-mentioned active repair material 400, non-woven fabric 200 and release paper 100, the release paper 100 is formed on the lower end surface of the non-woven fabric 200, and a wrapping bag 300 is arranged between the non-woven fabric 200 and the release paper 100. The wrapping bag 300 is specifically two groups of wrapping films sealed on all sides, and an air bag 1 500 and an air bag 2 600 are arranged inside the wrapping bag 300. Two groups of soluble microneedles 700 are arranged on the other side of the wrapping film adjacent to the non-woven fabric 200, and the active repair material 400 is applied to the corresponding position of the wrapping film adjacent to the release paper 100. The active repair material 400 corresponds to the position of a group of soluble microneedles 700. A pressing part is arranged on the side of the non-woven fabric away from the release paper, and the pressing part includes an elastic layer 800 and a balancing part 900. The midline of the elastic layer 800 coincides with the midline of the non-woven fabric.

[0051] Furthermore, the second air bag 600 surrounds the first air bag 500 inside, and the second air bag 600 corresponds to the position of another group of soluble microneedles 700.

[0052] Furthermore, the side of the air bag 1 500 facing away from the non-woven fabric 200 is a plane.

[0053] The plane of the air bag 1 500 facing away from the non-woven fabric 200 is coated with vaseline.

[0054] Furthermore, the height of the soluble microneedle 700 is 900 um, the bottom radius is 180 um, the tip radius is 10 um, and the thickness of the wrapping film is 300-500 um.

[0055] Furthermore, both ends of the elastic layer 800 are fixedly connected with an adhesive layer.

[0056] The thickness of the elastic layer 800 gradually decreases from the bonding side with the bonding layer to the fixed position with the non-woven fabric.

[0057] like Figure 4 and Figure 5 As shown, the adhesive layer begins to be received under the elastic layer 800.

[0058] It should be noted that the elastic layer 800 is made of elastic material, can be stretched and can deform and reset itself.

[0059] Furthermore, two groups of the balancing parts 900 are provided, the balancing parts 900 are fixedly connected to the non-woven fabric, and the edge of the balancing part 900 is aligned with an inner edge of the air bag.

[0060] The balancing part 900 is made of plastic material, such as PE, PET, and ABS.

[0061] Specifically, when in use, first make the active material area of ​​the repair material correspond to the wound site, then stick the repair patch to the wound site, and then pull out the adhesive portion 801 to deform the elastic layer 800 and then stick it to the peripheral area of ​​the repair patch. The adhesive portion 801 can enhance the adhesive effect of the repair patch, and under the action of the adhesive portion 801, the pressing portion will form a U shape, and the elastic layer 800 will press the balancing portion 900 to make the soluble microneedle pierce the wrapping film. The balancing portion 900 applies the pressure of the elastic layer 800 evenly to the repair material, so that the repair material is squeezed out. At the same time, as the wound continues to heal and the repair material is consumed, the elastic layer 800 will restore the deformation, keeping the repair material always under a certain pressure, thereby ensuring that the repair material is continuously squeezed out, so that a piece of repair patch can be used to maintain the wound to a healed state.

[0062] Furthermore, under the action of the equalizing part 900, the repair material can be ensured to be in a state of continuous extrusion, and as the wound heals and the active material is consumed, the extrusion amount of the repair material can be gradually reduced.

[0063] The active repair patch provided by the present invention is used for patients with smaller wounds or smaller wounds. The repair patch is attached to the affected area through the non-woven fabric 200, and then the repair patch is pressed to pierce the wrapping film through the soluble microneedle 700, and the active repair material 400 is applied to the affected area through the puncture hole. Since the repair material has a certain viscosity, the gas inside the air bag 2 600 is released through the puncture hole and then accumulated around the affected area. The air bag 2 600 will block the gas to ensure that the gas will not move to the affected area in a normal state, thereby preventing the non-woven fabric 200 from sticking to the affected area, causing the area around the affected area to be pulled when the repair patch is torn off for dressing change, causing pain to the patient.

[0064] Among them, the repair patch can effectively reduce the obstruction or incomplete growth of the healing area and the surrounding skin, which causes pulling pain when the repair patch is torn off during dressing changes.

[0065] Furthermore, since the air bag 2 600 has a cushioning effect, the pain caused by activities during the patient's healing process can be reduced.

[0066] The present invention also provides a method for preparing an active material repair patch, comprising the following steps: S1: Take the raw materials of the repair material according to the components; S2: Mixing and preparing active minerals according to raw materials; S3: an active repair material prepared by mixing the active minerals of S2 with sodium hyaluronate, medical vaseline, etc. according to the above proportions; S4: Disposing soluble microneedles on the surface of one set of wrapping films, and coating an appropriate amount of active repair material on the corresponding positions of another set of wrapping films; S5: aligning the two sets of wrapping films, firstly heat-pressing and sealing the edges of the two sets of wrapping films to form a wrapping bag, wherein the interior of the wrapping bag is filled with nitrogen, and then heat-pressing is performed to form two sets of air bags; S6: bonding the wrapping bag to the lower end surface of the non-woven fabric, and then covering the air bag with release paper to form a primary repair patch; S7: bonding the equalizing portion 900 to the rear of the initial repair patch and leaving a gap, bonding the middle of the elastic band to the reserved gap, and obtaining the repair patch.

[0067] Furthermore, the preparation process of the bioactive glass from the active mineral raw materials is as follows: after the bioactive glass raw materials are mixed in proportion, the bioactive glass is prepared by a sol-gel method or a hot melt / melting method, and after aging, drying, and crushing, the finished product is obtained by passing through a 50-mesh sieve.

[0068] In order to further understand the present invention, the wound active repair material 400 provided by the present invention is described below in conjunction with embodiments, and the protection scope of the present invention is not limited by the following embodiments. Example 1

[0069] 1. Recipe: Sodium hyaluronate 25%; active minerals 25%; medical vaseline 49%; the rest are excipients.

[0070] 2. Preparation method: The active minerals are mixed in proportion, prepared by a sol-gel method or a hot melt / melting method, aged, dried, and crushed, and then passed through a 50-mesh sieve to obtain a material with a particle size of no more than 300 um, which is then mixed with sodium hyaluronate, medical vaseline, etc. in the above proportion to produce an active wound repair material 400.

[0071] Example 2 1. Recipe: Sodium hyaluronate 25%; active minerals 30%; medical vaseline 44%; the rest are excipients.

[0072] The active minerals are specifically bioactive glass, tricalcium phosphate and hydroxyapatite 1:1:1.

[0073] The raw materials of the bioactive glass are composed according to the following weight ratios: 34.2% silicon dioxide; 0% sodium oxide; 44.9% calcium oxide; 16.3% phosphorus pentoxide; 0.5% calcium fluoride; 0% boron oxide; 0% zinc oxide; 0% copper oxide; 0% potassium oxide; and 4.6% magnesium oxide.

[0074] 2. Preparation method: Same as Example 1.

[0075] Example 3 1. Recipe: Sodium hyaluronate 20%; active minerals 32%; medical vaseline 47%; the rest are auxiliary materials.

[0076] The active minerals are specifically bioactive glass, tricalcium phosphate and hydroxyapatite 1:1:1.

[0077] The raw materials of the bioactive glass are composed according to the following weight ratios: 34.2% silicon dioxide; 0% sodium oxide; 44.9% calcium oxide; 16.3% phosphorus pentoxide; 0.5% calcium fluoride; 0% boron oxide; 0% zinc oxide; 0% copper oxide; 0% potassium oxide; and 4.6% magnesium oxide.

[0078] 2. Preparation method: Same as Example 1.

[0079] Example 4 1. Recipe: Sodium hyaluronate 35%; active minerals 20%; medical vaseline 44%; the rest are excipients.

[0080] The active minerals are specifically bioactive glass, tricalcium phosphate and hydroxyapatite 1:1:1.

[0081] The raw materials of the bioactive glass are composed according to the following weight ratios: 34.2% silicon dioxide; 0% sodium oxide; 44.9% calcium oxide; 16.3% phosphorus pentoxide; 0.5% calcium fluoride; 0% boron oxide; 0% zinc oxide; 0% copper oxide; 0% potassium oxide; and 4.6% magnesium oxide.

[0082] 2. Preparation method: Same as Example 1.

[0083] Example 5 1. Recipe: Sodium hyaluronate 36%; active minerals 38%; medical vaseline 25.5%; the rest are auxiliary materials.

[0084] The active minerals are specifically bioactive glass, tricalcium phosphate and hydroxyapatite 1:1:1.

[0085] The raw materials of the bioactive glass are composed according to the following weight ratios: 34.2% silicon dioxide; 0% sodium oxide; 44.9% calcium oxide; 16.3% phosphorus pentoxide; 0.5% calcium fluoride; 0% boron oxide; 0% zinc oxide; 0% copper oxide; 0% potassium oxide; and 4.6% magnesium oxide.

[0086] 2. Preparation method: Same as Example 1.

[0087] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An active material repair patch, characterized in that: It comprises a non-woven fabric and a release paper, wherein the release paper is formed on the lower end surface of the non-woven fabric, a wrapping bag is arranged between the non-woven fabric and the release paper, and the wrapping bag is specifically two groups of wrapping films sealed on all sides, an air bag 1 and an air bag 2 are arranged inside the wrapping bag, two groups of soluble microneedles are arranged on the other side of the wrapping film adjacent to the non-woven fabric, an active repair material is smeared on the corresponding position of the wrapping film adjacent to the release paper, and the active repair material corresponds to the position of a group of soluble microneedles, and a pressing part is arranged on the side of the non-woven fabric away from the release paper, and the pressing part comprises an elastic layer and a balancing part, and the midline of the elastic layer coincides with the midline of the non-woven fabric; The active repair material is prepared from the following sodium hyaluronate, active minerals, medical vaseline and excipients; The active mineral is specifically any one or more of bioactive glass, tricalcium phosphate and hydroxyapatite.

2. The active material repair patch according to claim 1, characterized in that: The second air bag surrounds the first air bag inside, and the second air bag corresponds to the position of another group of soluble microneedles.

3. The active material repair patch according to claim 2, characterized in that: The side of the air bag facing away from the non-woven fabric is a plane.

4. The active material repair patch and preparation method thereof according to claim 1, characterized in that: The bioactive glass is composed of any one or more of silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, calcium fluoride, boron oxide, zinc oxide, copper oxide, potassium oxide, and magnesium oxide.

5. The active material repair patch according to claim 1, characterized in that: The auxiliary materials are specifically one or more of glycerol, liquid paraffin, PEG, sodium carboxymethyl cellulose, a thickener, and a surfactant.

6. The active material repair patch according to claim 1, characterized in that: The height of the soluble microneedle is 900um, the bottom radius is 180um, the tip radius is 10um, and the thickness of the wrapping film is 300-500um.

7. The active material repair patch according to claim 1, characterized in that: Both ends of the elastic layer are fixedly connected with an adhesive layer.

8. The active material repair patch according to claim 1, characterized in that: There are two groups of the balancing parts, the balancing parts are fixedly connected to the non-woven fabric, and the edges of the balancing parts are aligned with an inner edge of the air bag.

9. A method for preparing the active material repair patch according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1: Take the raw materials of the repair material according to the components; S2: Mixing and preparing active minerals according to raw materials; S3: an active repair material prepared by mixing the active minerals of S2 with sodium hyaluronate, medical vaseline, etc. according to the above proportions; S4: Disposing soluble microneedles on the surface of one set of wrapping films, and coating an appropriate amount of active repair material on the corresponding positions of another set of wrapping films; S5: aligning the two sets of wrapping films, firstly heat-pressing and sealing the edges of the two sets of wrapping films to form a wrapping bag, wherein the interior of the wrapping bag is filled with nitrogen, and then heat-pressing is performed to form two sets of air bags; S6: bonding the wrapping bag to the lower end surface of the non-woven fabric, and then covering the air bag with release paper to form a primary repair patch; S7: Bond the balancing part to the rear of the initial repair patch and leave a gap, bond the middle of the elastic band to the reserved gap to obtain the repair patch.

10. The method for preparing a repair patch made of an active material according to claim 9, characterized in that: The preparation process of the bioactive glass from the active mineral raw materials is as follows: the bioactive glass raw materials are mixed in proportion, the bioactive glass is prepared by a sol-gel method or a hot melt / melting method, and after aging, drying, and crushing, the finished product is obtained by passing through a 50-mesh sieve.

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