A dry powder online liquid preparation device and method

Abstract

This invention proposes an online dispensing device and method for A dry powder. The top of the A dry powder containing module is connected to the bottom water circuit of the A liquid containing module. The top of the A liquid containing module is connected to the water circuit of the A liquid detection module. The A liquid detection module is connected to the water circuit of the first solenoid valve group. The water metering module is connected to the water circuits of the circulation power module, the overflow module, the first solenoid valve group, and the second solenoid valve group. The circulation power module is connected to the water circuit of the heating module. The heating module is connected to the water circuit of the overflow module. The overflow module is connected to the water circuit of the third solenoid valve group. The fourth solenoid valve group is connected to the water circuits of the third solenoid valve group and the bottom water circuit of the A dry powder containing module. This invention achieves rapid and complete dissolution of A dry powder, effectively obtaining dialysate of accurate concentration and improving the reliability of dispensing.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to an online preparation device and method for A dry powder. Background Technology

[0002] Dialysis fluid is divided into solution A and solution B. Solution B contains fewer substances, usually only sodium bicarbonate, or a small amount of sodium chloride and glucose. Solution A contains a variety of compounds, mainly sodium chloride, and also calcium chloride, magnesium chloride, potassium chloride, glacial acetic acid or citric acid. Solution A usually comes from three sources: (1) pre-prepared liquid in a factory and stored in plastic barrels. This method has the problem of easy contamination of the liquid. (2) centralized supply. A large-scale solution mixing system is installed to mix powder and reverse osmosis water and store the solution in a tank. It is then transported to the dialysis machine for use by the equipment through a pipeline system. This method is not convenient for personalized solution mixing ratio. (3) dry powder online. A single dose of dry powder is placed in a small bucket or bag and connected to the dialysis machine for online use. However, dry powder online is not currently used in clinical practice.

[0003] Currently, existing dry powder inline designs suffer from problems because dry powder A contains multiple compounds, making it difficult to dissolve to the precise concentration required by the formulation for each component, thus failing to generate qualified dialysate. In addition, the commonly used steps of electromagnetic stirring, heating, and powder discharge from the dry powder bag often take more than 30 minutes to dissolve. Furthermore, there are other issues such as undissolved dry powder remaining on the edge of the mixing tank and inside the dry powder bag, the dry powder bag outlet protruding due to the structure with the spray pipe on top and the blade on the bottom, creating dead zones for dry powder, lack of automatic venting, lack of automatic sterilization, and the large size of the chamber making sterilization difficult and time-consuming. These issues result in the inability to effectively obtain dialysate of accurate concentration, leading to poor reliability in solution preparation. Summary of the Invention

[0004] To address the aforementioned issues, this invention proposes an online solution preparation device and method for A dry powder, which enables the A dry powder to dissolve completely in a short time, effectively obtaining dialysate of accurate concentration and improving solution preparation reliability.

[0005] To achieve the above objectives, embodiments of the present invention provide an online liquid preparation device for dry powder A, comprising:

[0006] The system includes a dry powder container module, a liquid container module, a water metering module, a heating module, a liquid detection module, a first solenoid valve group, a second solenoid valve group, a third solenoid valve group, a fourth solenoid valve group, a circulating power module, an overflow module, and a control circuit module.

[0007] The top of the A dry powder containing module is connected to the bottom water channel of the A liquid containing module, the top of the A liquid containing module is connected to the water channel of the A liquid detection module, the A liquid detection module is connected to the water channel of the first solenoid valve group, the water volume metering module is connected to the water channels of the circulation power module, the overflow module, the first solenoid valve group and the second solenoid valve group respectively, the circulation power module is connected to the water channel of the heating module, the heating module is connected to the water channel of the overflow module, the overflow module is connected to the water channel of the third solenoid valve group, and the fourth solenoid valve group is connected to the bottom water channel of the third solenoid valve group and the A dry powder containing module respectively.

[0008] The A dry powder containing module, the A liquid containing module, the water metering module, the heating module, the A liquid detection module, the first solenoid valve group, the second solenoid valve group, the third solenoid valve group, the fourth solenoid valve group, and the circulation power module are all electrically connected to the control circuit module. The control circuit module is used to receive the installation completion signal of the A dry powder containing module, to send control signals to control the A liquid containing module to change its volume, to receive the water level detection signal from the water metering module, to control the heating module to heat the liquid in the water circuit, to control the A liquid detection module to detect the liquid in the water circuit, to control the opening and closing of the first solenoid valve group, the second solenoid valve group, the third solenoid valve group, and the fourth solenoid valve group, and to control the circulation power module to transport the liquid in the water metering module to the heating module.

[0009] Furthermore, the bottom and top of the A dry powder containing module are both wedge-shaped, and the bottom angle of the A dry powder containing module is smaller than the top angle; the bottom and top of the A liquid containing module are also wedge-shaped.

[0010] Furthermore, the volume of the A dry powder containing module is at least equal to a preset multiple of the A dry powder volume, and the volume of the A dry powder containing module is at most equal to the maximum volume of the A liquid containing module.

[0011] Furthermore, the liquid A containment module includes: a soft cavity and two wall panels. The soft cavity is capable of changing its volume along a first direction. The two wall panels are parallel and spaced apart along the first direction. The soft cavity is disposed between the two wall panels and connected to the two wall panels.

[0012] Furthermore, the overflow module includes: an air separation chamber and an overflow valve; the air separation chamber and the overflow valve are connected by a water circuit, the air separation chamber is connected by a water circuit to the heating module, and the overflow valve is connected by a water circuit to the water metering module;

[0013] The air separation chamber is used to separate gas and liquid so that the gas is above the liquid; the overflow valve is used to overflow the gas and liquid to the water metering module when the water pressure in the air separation chamber is greater than the back pressure of the overflow valve.

[0014] Furthermore, the water metering module is equipped with a float, and the water metering module is equipped with at least two detection positions, upper and lower, to detect the position of the float and obtain a water level detection signal; the top of the water metering module is equipped with an exhaust port and an air inlet.

[0015] This invention also provides a method for online preparation of A dry powder, including: receiving an installation completion signal from the A dry powder containing module and selecting to enter the A liquid preparation mode;

[0016] The system receives water level detection signals from the water metering module in real time. When the water level detection signal meets the preset metering requirements, it controls the second solenoid valve group to close and controls the circulating power module to transport the liquid in the water metering module to the heating module.

[0017] The heating module is controlled to heat the liquid in the water circuit. When the liquid temperature in the water circuit meets the preset requirements, the third solenoid valve group and the fourth solenoid valve group are controlled to open, and the liquid is input from the bottom of the A dry powder receiving module to dissolve the A dry powder and obtain the A dry powder solution.

[0018] The A dry powder dissolving solution is fed from the top of the A dry powder containing module to the bottom of the A liquid containing module, and then output from the top of the A liquid containing module.

[0019] The A liquid detection module is controlled to sequentially perform conductivity and optical detection on the A dry powder solution output from the top of the A liquid containing module;

[0020] The first solenoid valve group is controlled to open, and the A dry powder solution that has completed conductivity and optical detection is circulated and dissolved until the conductivity and optical detection analysis results of the A dry powder solution meet the preset solution preparation requirements and the number of times the A dry powder solution is circulated and dissolved meets the preset number of cycles requirement, thus determining that the A dry powder solution has met the preset solution preparation requirements.

[0021] Furthermore, the method for online dispensing of dry powder A proposed in this embodiment of the invention further includes: setting a float in the water metering module;

[0022] The water level in the water metering module is measured and detected by the number of float movements of the water metering module, and a water level detection signal is obtained.

[0023] During the liquid circulation and dissolution process, when the water level detection signal result does not meet the preset measurement requirements, the second solenoid valve group is controlled to open;

[0024] When the water level detection signal meets the preset metering requirements, the first solenoid valve group is controlled to open, and the A dry powder solution that has completed conductivity and optical detection is circulated and dissolved until the conductivity and optical detection analysis results of the A dry powder solution both meet the preset solution preparation requirements and the number of cycles of A dry powder solution dissolution meets the preset cycle number requirements, and it is determined that the A dry powder solution has met the preset solution preparation requirements. This includes: controlling the first solenoid valve group to open, and conveying the A dry powder solution that does not meet the preset solution preparation requirements through the bottom of the A liquid containing module to the water metering module;

[0025] The circulating power module is controlled to transport the A dry powder solution in the water metering module to the heating module for heating and dissolution, so as to obtain the heated A dry powder solution.

[0026] The third and fourth solenoid valve groups are controlled to open, so that the heated A dry powder dissolving solution is input from the bottom of the A dry powder containing module, and then output from the top of the A dry powder containing module and input from the bottom of the A liquid containing module into the A liquid containing module in sequence to complete one cycle of dissolution.

[0027] The A-liquid detection module sequentially performs conductivity and optical detection on the A dry powder solution that has completed one cycle of dissolution and analyzes it. The above cycle dissolution steps are repeated until the conductivity and optical detection analysis results of the A dry powder solution meet the preset solution preparation requirements and the number of cycles of dissolution of the A dry powder solution meets the preset cycle number requirements, thus confirming that the A dry powder solution has met the preset solution preparation requirements.

[0028] Furthermore, the online preparation method for dry powder A proposed in this embodiment of the invention further includes: when the conductivity and optical detection and analysis results of the dry powder A solution meet the preset preparation requirements, selecting to enter the A solution usage mode;

[0029] After the A-liquid usage mode ends, the A-liquid container module is restored to its minimum volume state to disinfect the circulating water circuit and the A-liquid container module.

[0030] Beneficial effects:

[0031] (1) By adding an A liquid containing module, the dissolution of A dry powder is not limited to the A dry powder containing module. The solution flows in from the bottom and out from the top of the A dry powder containing module, and flows in from the bottom and out from the top of the A liquid containing module, which can make the A dry powder fully dissolved. The A dry powder containing module is set to be wedge-shaped at the top and bottom. The top facilitates the removal of air, and the bottom facilitates the full drainage and dissolution of liquid, reducing the residue of liquid and dry powder.

[0032] (2) Heating and dissolving are achieved by setting up a heating module to improve dissolution efficiency; the conductivity and optical properties of the A dry powder solution are detected in real time by setting up an A liquid detection module, and the results of the conductivity and optical properties are analyzed to determine whether the A dry powder is fully dissolved; the circulation dissolution path is realized through the interconnection structure of the A dry powder container module, A liquid container module, water metering module, circulation power module, overflow module and heating module, which further improves dissolution efficiency, and finally achieves full dissolution of A dry powder, and can effectively obtain dialysate of accurate concentration to improve the reliability of solution preparation. Attached Figure Description

[0033] Figure 1 A schematic diagram of the module structure of an A dry powder online liquid preparation device provided in a certain embodiment of the present invention. Figure 1 ;

[0034] Figure 2 A schematic diagram of the module structure of an A dry powder online liquid preparation device provided in a certain embodiment of the present invention. Figure 2 ;

[0035] Figure 3 A schematic diagram of the module structure of an A dry powder online liquid preparation device provided in a certain embodiment of the present invention. Figure 3 ;

[0036] Figure 4 A schematic diagram of the structure of the A dry powder containing module of an online liquid preparation device for A dry powder provided in a certain embodiment of the present invention. Figure 1 ;

[0037] Figure 5 A schematic diagram of the structure of the A dry powder containing module of an online liquid preparation device for A dry powder provided in a certain embodiment of the present invention. Figure 2 ;

[0038] Figure 6 A schematic diagram of the structure of the A dry powder containing module of an online liquid preparation device for A dry powder provided in a certain embodiment of the present invention. Figure 3 ;

[0039] Figure 7 A schematic diagram of the structure of the A dry powder containing module of an online liquid preparation device for A dry powder provided in a certain embodiment of the present invention. Figure 4 ;

[0040] Figure 8 A schematic diagram of the structure of the A liquid containing module of an A dry powder online dispensing device provided in a certain embodiment of the present invention. Figure 1 ;

[0041] Figure 9 A schematic diagram of the structure of the A liquid containing module of an A dry powder online dispensing device provided in a certain embodiment of the present invention. Figure 2 ;

[0042] Figure 10 This is a schematic flowchart of a method for online preparation of dry powder A according to a certain embodiment of the present invention;

[0043] Figure 11 This is a schematic diagram illustrating the dynamic changes in the solubility of a dry powder A in an online liquid preparation method according to a certain embodiment of the present invention;

[0044] Figure 12 This is a schematic diagram of the solution conductivity change in an online solution preparation method for dry powder A provided in a certain embodiment of the present invention;

[0045] Reference numerals: 101, Dry powder container module; 102, Liquid A container module; 103, Water metering module; 104, Heating module; 105, Liquid A detection module; 106, First solenoid valve group; 107, Second solenoid valve group; 108, Third solenoid valve group; 109, Fourth solenoid valve group; 110, Circulation power module; 111, Overflow module; 112, Control circuit module; 201, Dry powder A container / bag; 202, Variable volume liquid A chamber; 203, Metering water tank; 204, Flow pump; 205. Heater; 206. Conductivity detector; 207. Optical detector; 208. Temperature sensor; 209. Overflow valve; 2010. Air separation chamber; K1. First solenoid valve; K2. Second solenoid valve; K3. Third solenoid valve; K4. Fourth solenoid valve; 1. Bag body; 2. Support component; 21. Interface end; 22. Support rod; 3. Interface component; 31. Bucket body; 501. Motor; 502. Screw; 503. First wall panel; 504. Soft cavity; 505. Second wall panel. Detailed Implementation

[0046] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0047] Example 1

[0048] See Figure 1 , Figure 1 A schematic diagram of the module structure of an A dry powder online liquid preparation device provided in a certain embodiment of the present invention. Figure 1 .like Figure 1 As shown in the figure, this embodiment of the invention proposes an A dry powder inline liquid preparation device, including: an A dry powder containing module 101, an A liquid containing module 102, a water metering module 103, a heating module 104, an A liquid detection module 105, a first solenoid valve group 106, a second solenoid valve group 107, a third solenoid valve group 108, a fourth solenoid valve group 109, a circulation power module 110, an overflow module 111, and a control circuit module 112; the top of the A dry powder containing module 101 is connected to the bottom water channel of the A liquid containing module 102, and the top of the A liquid containing module 102 is connected to the A liquid detection module. Module 105 is connected to the water circuit; Liquid A detection module 105 is connected to the water circuit of the first solenoid valve group 106; Water metering module 103 is connected to the water circuits of the circulation power module 110, overflow module 111, first solenoid valve group 106 and second solenoid valve group 107 respectively; Circulation power module 110 is connected to the water circuit of the heating module 104; Heating module 104 is connected to the water circuit of the overflow module 111; Overflow module 111 is connected to the water circuit of the third solenoid valve group 108; Fourth solenoid valve group 109 is connected to the bottom water circuit of the third solenoid valve group 108 and the A dry powder containing module 101 respectively.

[0049] By designing this circulating dissolution path, the A dry powder can be fully dissolved. Furthermore, the dissolution path, with the A liquid containing module 102 flowing in from the bottom and out from the top, along with the heating module 104, reduces the residue of the A dry powder and accelerates the dissolution efficiency. One specific implementation method is described in [reference needed]. Figure 3 , Figure 3 A schematic diagram of the module structure of an A dry powder online liquid preparation device provided in a certain embodiment of the present invention. Figure 3 In this embodiment, the following will be adopted: Figure 3 The diagram shows a structural schematic of an A-powder online solution preparation device for use in hemodialysis equipment. Figure 3 Combination Figure 1 The schematic diagram of the A dry powder online liquid preparation device shown is as follows. Figure 1The explanation will not be repeated below. The A dry powder online liquid dispensing device includes: A dry powder barrel / bag 201 (equivalent to A dry powder containing module 101), variable volume A liquid chamber 202 (equivalent to A liquid containing module 102), metering water tank 203 (equivalent to water metering module 103), flow pump 204 (equivalent to circulation power module 110), heater 205 (equivalent to heating module 104), conductivity detector 206 and optical detector 207 (the combination of which is equivalent to A liquid detection module 105), temperature sensor 208, overflow valve 209 and air separation chamber 2010 (the combination of which is equivalent to... The overflow module 111), the first solenoid valve K1 (equivalent to the first solenoid valve group 106), the second solenoid valve K2 (equivalent to the second solenoid valve group 107), the third solenoid valve K3 (equivalent to the third solenoid valve group 108), and the fourth solenoid valve K4 (equivalent to the fourth solenoid valve group 109) are included. It is worth mentioning that the first solenoid valve group 106, the second solenoid valve group 107, the third solenoid valve group 108, and the fourth solenoid valve group 109 can all be composed of one or more solenoid valves connected together. The number of solenoid valves can be adjusted according to the actual application scenario, which will not be elaborated here.

[0050] Existing dry powder containers are typically very large, causing numerous problems in storage and transportation. This invention proposes a dry powder containing module 101. The bottom and top of the dry powder containing module 101 are wedge-shaped, with the bottom angle smaller than the top angle. The volume of the dry powder containing module 101 is at least equal to a preset multiple of the dry powder volume, and at most equal to the maximum volume of the liquid containing module 102. The top and bottom of the dry powder containing module 101... The part is equipped with a filtration structure; in this embodiment of the invention, the A dry powder containing module 101 is used to store A dry powder. The A dry powder containing module 101 can be set as an A dry powder bucket / bag 201. The A dry powder bucket / bag 201 is disposable, produced by the dialysis powder factory, and sealed in packaging. It is only unpacked and connected to the A dry powder support of the dialysis machine when needed. The A dry powder bucket / bag 201 can also be reused, but if reused, it needs to be disinfected and cleaned. Furthermore, the volume of the A dry powder bucket / bag 201 needs to be large enough, greater than 1 / 3 of the volume of A dry powder. The powder concentration is 0.5 times (equivalent to a preset multiplier), ensuring that the powder is concentrated at the bottom during dissolution, minimizing the amount of powder in the liquid flowing out from the top and preventing clogging and wear on the gear pump. Simultaneously, the volume of the A dry powder container / bag 201 is minimized, smaller than the maximum volume of the variable volume A liquid chamber 202. Sealed packaging facilitates transportation and storage. The A dry powder container / bag 201 features a wedge-shaped bottom and top, with the bottom angle smaller than the top angle. The wedge shape at the top facilitates air expulsion and prevents undissolved powder from flowing into the gear pump, while the larger angle allows for increased volume. The smaller wedge shape at the bottom ensures complete liquid drainage and thorough dissolution. A filter structure is installed at the bottom of the A dry powder container / bag 201 to prevent powder leakage during disassembly and reassembly. A filter structure is also installed at the top of the A dry powder container / bag 201 to prevent powder leakage after overflow. During use, the A dry powder container / bag 201 is placed outside the dialysis equipment and connected to the A dry powder support, similar to the existing mature B dry powder container installation method. The A dry powder support is equipped with a detector to check for installation.

[0051] As one possible implementation method of this embodiment, see Figure 4 , Figure 4 A schematic diagram of the structure of the A dry powder containing module of an online liquid preparation device for A dry powder provided in a certain embodiment of the present invention. Figure 1 ;like Figure 4 As shown, one type of A dry powder bucket / bag 201 is configured as an A dry powder bucket, which includes: a bucket body 31 and two interface pieces 3, the interface pieces 3 being used to connect the A dry powder bucket to the dialysis equipment; the top and bottom of the bucket body 31 are wedge-shaped, and the filter structure is set at the two ends of the bucket body 31 facing the two interface pieces 3.

[0052] As another possible implementation method of this embodiment, see Figures 5 to 7Another configuration of the A dry powder can / bag 201 is the A dry powder bag, which includes: a bag body 1, a support member 2, and two interface members 3. The support member 2 is connected between the interface members 3 at the top and bottom. The support member 2 can have two interface ends 21 and at least one support rod 22. The support rod 22 is located inside the bag body 1, and its two ends are respectively connected to the corresponding interface ends 21. The two ends of the bag body 1 are sealed to the interface ends 21 by heat fusion. It is worth mentioning that, see... Figure 6 The support rod 22 can be configured as follows: the connection between the two interface ends 21 and the support rod 22 is funnel-shaped. The funnel-shaped structure of the interface ends 21 has several filter holes (i.e., a filter structure). The funnel opening of the bottom interface end 21 faces downward, and the funnel opening of the top interface end 21 faces upward. The support rod 22 can be a solid column or a tube structure closed at both ends. The support rod 22 does not allow liquid to pass through, ensuring that liquid can only enter and exit the bag body 1 through the filter holes on the funnel-shaped structure of the interface ends 21. See also... Figure 7 The support rod 22 can also be configured in a second way: the connection points between the two interface ends 21 and the two support rods 22 are funnel-shaped, and the support rod 22 is a solid column or a tube structure with closed ends; in addition, if the support rod 22 is replaced with a support tube, the support tube is a support tube with multiple openings to facilitate the passage of liquid.

[0053] To better promote the dissolution of powder A, a method that increases the dissolution path is adopted. One specific implementation method is described in [link to implementation details]. Figure 8 and Figure 9 This invention provides an A-liquid containing module 102, wherein the bottom and top of the A-liquid containing module 102 are wedge-shaped; the wedge shape at the top facilitates air discharge, and the wedge shape at the bottom facilitates the emptying of liquid within the cavity; the A-liquid containing module 102 includes: a soft cavity 504 and two wall plates (equivalent to a first wall plate 503 and a second wall plate 505), the soft cavity 504 can change its volume along a first direction, and the two wall plates are parallel and spaced apart along the first direction, which is the direction in which the volume of the soft cavity 504 increases, such as... Figure 8 and Figure 9 As indicated by the middle arrow; the soft cavity 504 is disposed between the two wall panels and connected to the two wall panels; the bottom of the soft cavity 504 is connected to the top water channel of the A dry powder bucket / bag 201; the top of the soft cavity 504 is connected to the water channel of the conductivity detector 206.

[0054] One possible implementation is that the variable-volume A-liquid cavity 202 (equivalent to the A-liquid containing module 102) consists of a soft cavity (equivalent to the soft cavity 504) and two wall panels (equivalent to the first wall panel 503 and the second wall panel 505). One possible implementation of the soft cavity is that it adopts a structure similar to a hot water bottle, with the outer sides of the cavity connected to the wall panels (e.g., bonded). Thus, the direction of volume increase for the variable-volume A-liquid cavity 202 is perpendicular to the direction in which the two wall panels compress the soft cavity. Figure 3 As shown, when the variable-volume A-fluid chamber 202 has a larger volume, the distance between the two side walls is greater, and vice versa. The soft cavity material can be fluororubber or silicone. In addition, since the volume of the variable-volume A-fluid chamber 202 is variable, it is in its maximum volume state during preparation and dialysis treatment, which, together with the A dry powder container / bag 201, is sufficient to hold one person's dose of concentrated dialysis solution. When the dialysis machine is cleaned and disinfected after treatment, the variable-volume A-fluid chamber 202 is in its minimum volume state, which facilitates shortening the disinfection and cleaning time. Furthermore, the variable-volume A-fluid chamber 202 (equivalent to the A-fluid containing module 102) also includes: a motor 501 and a screw 502. The distance between the two side walls can be controlled by the motor 501 and the screw 502. The expansion or contraction of the cavity can also be controlled by the water pressure, and the side walls can be locked in the extreme position by an electromagnet. The variable-volume A-fluid chamber 202 is fixedly placed inside the hemodialysis equipment.

[0055] To achieve degassing and venting during the dissolution cycle, thereby improving the dissolution efficiency of powder A, an overflow module 111 is provided in this embodiment. The overflow module 111 includes an air separation chamber 2010 and an overflow valve 209. The air separation chamber 2010 and the overflow valve 209 are connected by a water circuit. The air separation chamber 2010 is connected to the heating module 104 by a water circuit, and the overflow valve 209 is connected to the water metering module 103 by a water circuit. The air separation chamber is used to separate gas and liquid so that the gas is above the liquid. The overflow valve 209 is used to overflow the gas and liquid to the water metering module 103 when the water pressure in the air separation chamber is greater than the back pressure of the overflow valve 209. The overflow module 111 has two paths: one flows from the air separation chamber 2010 back to the metering water tank 203 through the overflow valve 209, and the other flows from the air separation chamber 2010 through the third solenoid valve K3 and the fourth solenoid valve K4 to the bottom of the powder A receiving module 101.

[0056] To accurately detect the degree of liquid dissolution and improve the reliability of solution preparation, this embodiment of the invention also proposes an A-liquid detection module 105. The A-liquid detection module 105 is used to detect the sufficiency of dissolution and the qualification of ion concentration. The A-liquid detection module 105 includes: a conductivity detector 206 and an optical detector 207, which are located between the top outlet of the variable volume A-liquid chamber 202 and the first solenoid valve K1. The conductivity detector 206 can be a traditional concentrated liquid conductivity detection probe. By setting the conductivity detector 206 to detect the conductivity, the rate of change of conductivity can be analyzed to determine whether the A dry powder is still dissolving. By detecting whether the conductivity of the dissolved liquid is within the preset qualified range, the qualification of ion concentration can be determined. The optical detector 207 adopts an optical detection method and is composed of a light-emitting tube and a photoelectric receiving tube. The light emitted by the light-emitting tube passes through the A dry powder dissolution liquid. By analyzing the change in the light intensity received by the photoelectric receiving tube, it is determined whether the A dry powder is still dissolving.

[0057] Existing technologies typically cannot monitor and control the influent volume of the solution, which can easily lead to deviations in the accuracy of solution A preparation. To address this technical deficiency, this invention proposes a water metering module 103. The water metering module 103 is equipped with a float, and at least two detection positions (upper and lower) are set to detect the position of the float to obtain a water level detection signal. The top of the water metering module 103 is provided with an exhaust port and an air inlet. In one specific implementation, the water metering module 103 is configured as a metering water tank 203. A float is installed in the metering water tank 203, and the float has at least two detection positions, an upper position and a lower position. The top of the water tank is provided with an exhaust port and an air inlet. The upper and lower position detection of the float in the metering water tank 203 can be used to measure the water for preparation. The exhaust port is used to remove air during the dissolution process. The exhaust port and air inlet can cope with the overall volume fluctuation during the circulation dissolution process. The bottom outlet of the metering water tank 203 is connected to a flow pump 204 (or a gear pump, to provide circulation power). The metering water tank 203 is also connected to a first solenoid valve group 106 and a second solenoid valve group 107. The opening and closing of the second solenoid valve group 107 is controlled according to the water level detection signal so that the liquid volume in the circulation loop can be accurately controlled.

[0058] This invention provides an online liquid preparation device for dry powder A, which, in addition to water circuit connection, also has electrical circuit connection. See details below. Figure 2 , Figure 2 A schematic diagram of the module structure of an A dry powder online liquid preparation device provided in a certain embodiment of the present invention. Figure 2 ;like Figure 2As shown, the A dry powder containing module 101, A liquid containing module 102, water metering module 103, heating module 104, A liquid detection module 105, first solenoid valve group 106, second solenoid valve group 107, third solenoid valve group 108, fourth solenoid valve group 109, and circulation power module 110 are all electrically connected to the control circuit module 112. The control circuit module 112 is used to receive the installation completion signal of the A dry powder containing module 101, and to send control signals to control the A liquid containing module 102 to change its volume. The control circuit module 112 receives the water level detection signal from the water metering module 103, controls the heating module 104 to heat the liquid in the water circuit, controls the A liquid detection module 105 to detect the liquid in the water circuit, controls the opening and closing of the first solenoid valve group 106, the second solenoid valve group 107, the third solenoid valve group 108 and the fourth solenoid valve group 109, and controls the circulation power module 110 to transport the liquid in the water metering module 103 to the heating module 104. One possible implementation includes a control system (equivalent to control circuit module 112) for receiving signals indicating the completion of installation of the A dry powder bucket / bag 201 (equivalent to A dry powder containing module 101), receiving water metering signals from the metering water tank 203, and receiving temperature signals from the temperature sensor 208. It is also used to control the heater 205 for heating and to control the on / off states of the first solenoid valve K1, the second solenoid valve K2, the third solenoid valve K3, and the fourth solenoid valve K4. The control system can select between the A liquid preparation mode and the A liquid usage mode based on the received parameters.

[0059] It is worth mentioning that the metering water tank 203, flow pump 204, heater 205, temperature sensor 208, overflow valve 209, and control system (equivalent to control circuit module 112) proposed in this embodiment can be shared with the same components inside the dialysis equipment and can also be embedded into the water circuit system of the dialysis equipment. The connection between the water inlet end of the metering water tank 203 and the outlet end of the heater 205 is shared with the dialysis equipment, and the bottom of the A dry powder bucket / bag 201 is connected to the A liquid suction end of the dialysis equipment. By sharing components, it is only necessary to add a variable volume A liquid chamber 202, a conductivity detector 206, an optical detector 207, and two solenoid valves to the original dialysis equipment.

[0060] This invention provides an online dispensing device for dry powder A. By adding a liquid A container module 102, the dissolution of dry powder A is not limited to the dry powder container module 101. The solution flows in from the bottom and out from the top of the dry powder container module 101, and also flows in from the bottom and out from the top of the liquid A container module 102. This ensures thorough dissolution of the dry powder A. Furthermore, the dry powder container module 101 is wedge-shaped at the top and bottom, facilitating air removal at the top and ensuring complete drainage and dissolution of the liquid at the bottom, reducing liquid and powder residue. A heating module 104 is used to achieve heating... Thermal dissolution improves dissolution efficiency. An A-liquid detection module 105 performs real-time conductivity and optical detection on the A-powder dissolution solution, analyzing the results to determine if the A-powder is fully dissolved. A circulating dissolution path is established through the interconnected structure of the A-powder containing module 101, A-liquid containing module 102, water metering module 103, circulation power module 110, overflow module 111, and heating module 104, further improving dissolution efficiency and ultimately achieving complete dissolution of the A-powder. This also enables the acquisition of accurate dialysis solution concentrations, enhancing the reliability of solution preparation.

[0061] Based on the embodiments of the present invention, an online dispensing device for dry powder A is proposed, which can correspondingly execute an online dispensing method for dry powder A. The principle is as follows: See Figure 10 , Figure 10 This is a schematic flowchart illustrating the steps of an online liquid preparation method for dry powder A, provided in a certain embodiment of the present invention. Figure 10 As shown in the figure, this embodiment of the invention proposes an online liquid preparation method for dry powder A, including steps 701 to 706, each step of which is as follows:

[0062] Step 701: Receive the installation completion signal of the A dry powder containing module and select to enter the A liquid preparation mode;

[0063] As an example of this embodiment, after the A dry powder bucket / bag 201 is installed on the A dry powder bracket, the device can detect that the A dry powder bucket / bag 201 has been installed through the position detector, and send the installation completion signal to the control circuit module 112. The A liquid preparation information appears on the interface of the control circuit module 112. After confirmation, the control circuit module 112 starts the A concentrate preparation program to dissolve the A dry powder in one go. Before the control circuit module 112 starts, the system will also use its own conductivity detection system to determine whether the liquid in the water tank has been cleaned sufficiently and no longer contains dialysate, and then send a control signal to control the opening of the second solenoid valve K2, the flow pump 204 and the heater 205.

[0064] Step 702: Receive the water level detection signal from the water metering module in real time. When the water level detection signal meets the preset metering requirements, control the second solenoid valve group 107 to close and control the circulating power module 110 to transport the liquid in the water metering module to the heating module.

[0065] As an example of this embodiment, the water level in the water metering module is measured and detected by the number of float movements of the water metering module to obtain a water level detection signal. During the liquid circulation and dissolution process, when the water level detection signal does not meet the preset measurement requirements, the second solenoid valve group 107 is controlled to open; when the water level detection signal meets the preset measurement requirements, the second solenoid valve group 107 is controlled to close. Specifically, the water inlet capacity is measured by the number of float movements of the metering tank 203 to ensure accurate water injection. When the total volume of the metering tank 203 reaches the water volume required for preparing solution A, the water inlet solenoid valve is closed, and the filling process ends. In one application explanation, when the number of float movements reaches the preset water inlet volume requirement, a water volume satisfaction signal is sent to the control circuit module 112, and the control circuit module 112 controls the second solenoid valve K2 at the water inlet to close. Furthermore, the heater 205 controls the temperature of the heated water to be close to or slightly higher than the temperature of the usual dialysate, such as 37-41°C. Injecting this heated water can significantly shorten the dissolution time, especially in seasons with lower temperatures.

[0066] Step 703: Control the heating module to heat the liquid in the water circuit. When the liquid temperature in the water circuit meets the preset requirements, control the third solenoid valve group 108 and the fourth solenoid valve group 109 to open, and input the liquid from the bottom of the A dry powder receiving module to dissolve the A dry powder and obtain the A dry powder solution.

[0067] As an example of this embodiment, the heater 205 heats the liquid in the water circuit. When the water temperature detected by the temperature sensor 208 reaches the preset requirement, the third and fourth solenoid valves are opened, allowing the hot water to enter from the bottom of the A dry powder bucket / bag 201. Undissolved A dry powder sinks to the bottom of the A dry powder bucket / bag 201 due to gravity, which makes the dissolution effect optimal. After the A dry powder bucket / bag 201 is filled, since the container volume is more than 1.5 times the A dry powder volume, the powder is concentrated at the bottom. Therefore, the liquid overflowing from the wedge-shaped top outlet contains the least amount of undissolved powder, resulting in a dissolved A dry powder solution.

[0068] Step 704: Input the A dry powder dissolving solution from the top of the A dry powder receiving module to the bottom of the A liquid receiving module, and output it from the top of the A liquid receiving module;

[0069] As an example of this embodiment, the A dry powder dissolving liquid further flows into the variable volume A liquid chamber 202, also entering from the wedge-shaped bottom. After a small amount of undissolved powder enters the variable volume A liquid chamber 202, it first concentrates in the lower part of the variable volume A liquid chamber 202 and is output from the top of the A liquid containing module 102.

[0070] Step 705: Control the A liquid detection module to perform conductivity and optical detection on the A dry powder solution output from the top of the A liquid container module in sequence;

[0071] As an example of this embodiment, after filling is completed, the flow pump 204 continues to operate, and the A dry powder dissolving liquid flows out from the wedge-shaped top of the variable volume A liquid chamber 202. It contains less undissolved powder, which avoids wear on gear pumps, etc. At the same time, it prioritizes the discharge of air. After the A dry powder dissolving liquid flows out from the variable volume A liquid chamber 202, it passes through the conductivity detector 206 and the optical detector 207 and returns to the metering water tank 203, thus entering the circulation dissolving stage.

[0072] Step 706: Control the first solenoid valve group to open, and circulate the A dry powder solution that has completed conductivity and optical detection to dissolve it until the conductivity and optical detection analysis results of the A dry powder solution meet the preset solution preparation requirements and the number of cycles of A dry powder solution dissolving meets the preset cycle requirements, thus determining that the A dry powder solution has met the preset solution preparation requirements.

[0073] As an example of this embodiment, the first solenoid valve group is controlled to open, and the A dry powder solution whose conductivity and optical detection analysis results do not meet the preset solution preparation requirements is transported through the bottom of the A liquid containing module to the water metering module; the circulation power module is controlled to transport the A dry powder solution in the water metering module to the heating module for heating and dissolution, to obtain the heated A dry powder solution; the third and fourth solenoid valve groups are controlled to open, and the heated A dry powder solution is input from the bottom of the A dry powder containing module, and then output from the top of the A dry powder containing module and input from the bottom of the A liquid containing module to the A liquid containing module in sequence to complete one cycle of dissolution; the A liquid detection module sequentially performs conductivity and optical detection on the A dry powder solution that has completed one cycle of dissolution, and the control circuit module 112 analyzes and processes the conductivity and optical detection information of the A liquid detection module, repeating the above cycle dissolution steps until the conductivity and optical detection analysis results of the A dry powder solution both meet the preset solution preparation requirements and the number of cycles of dissolution of the A dry powder solution meets the preset number of cycles, to determine that the A dry powder solution meets the preset solution preparation requirements. Specifically, during the circulation dissolution stage, heater 205 is appropriately turned off or slightly heated with low power (e.g., maintained at 37-41°C) to prevent the volatile components in powder A from evaporating. The powder A solution continuously circulates and dissolves along a water flow path, from powder A container module 101 to liquid A container module 102, then to water metering module 103, then to circulation power module 110, heating module 104, and overflow module 111, returning to powder A container module 101. This process repeats continuously. Each time the liquid flows through conductivity detector 206 and optical detector 207, conductivity and optical detection are performed, and the detection signals are sent to the control circuit module. 112. The control circuit module 112 analyzes the rate of change of conductivity and the rate of change of light intensity received by the photodetector to determine whether the A dry powder is fully dissolved. If the A dry powder is fully dissolved, the control circuit module 112 determines whether the conductivity is within the acceptable range. If the conductivity is unacceptable, the dissolution ends and an alarm is issued. If the conductivity is acceptable, the control circuit module 112 determines whether the number of cycles is greater than 2. When the number of cycles is greater than 2, the control circuit module 112 sends a control signal to sequentially close the second solenoid valve K2, the third solenoid valve K3, and the fourth solenoid valve K4, so that the A dry powder solution is stored in the variable volume A liquid chamber 202 and the A dry powder bucket / bag 201 for later use.

[0074] During the cyclic dissolution process, the A-liquid detection module 105 outputs optical and conductivity detection signals of the A-powder dissolution solution to the control circuit module 112 in real time. The control circuit module 112 analyzes the conductivity change rate, the light intensity signal change rate received by the photodetector, and whether the conductivity falls within the acceptable range to obtain the dissolution degree analysis results and ion concentration qualification results of the A-powder dissolution solution. When the dissolution degree analysis results and ion concentration results of the A-powder dissolution solution meet the preset solution preparation requirements, the A-liquid usage mode is selected. After the A-liquid usage mode ends, the A-liquid container module 102 is controlled to return to its minimum volume state, and the circulating water circuit and the A-liquid container module 102 are disinfected. Specifically, during the cyclic dissolution stage, the control circuit module 112 collects the light intensity (i.e., the AD value at the receiving end) received by the photodetector in real time, processes and analyzes the collected data, and calculates the light intensity change rate. Figure 11 This is a schematic diagram illustrating the dynamic changes in the solubility of a dry powder A in an online dissolution method according to a certain embodiment of the present invention, as shown below. Figure 11 As shown, with the change of dissolution time, the content of powder particles in the liquid gradually decreases, the light intensity received by the photodetector increases, and the rate of change of light intensity gradually flattens and approaches 0. Therefore, the rate of change of light intensity received by the photodetector can reflect the degree of particle dissolution. In addition, the control circuit module 112 of the cyclic dissolution stage collects the conductivity data of the dissolved A dry powder detected by the conductivity detector 206, processes and analyzes the collected data, calculates the rate of change of conductivity, and determines whether the conductivity falls within the preset qualified range. Figure 12 This is a schematic diagram illustrating the change in solution conductivity of a dry powder A online solution preparation method according to a certain embodiment of the present invention, as shown below. Figure 12 As shown, the conductivity of the solution increases with the change of dissolution time, and the rate of change of conductivity gradually flattens and approaches 0. Therefore, the rate of change of conductivity can reflect the degree of particle dissolution. After the rate of change of light intensity received by the photodetector tube and the rate of change of conductivity detected by the conductivity detector 206 both meet the requirements and the conductivity of the A dry powder dissolution solution meets the preset conductivity qualified range requirements, the cycle dissolution process ends, the A solution is prepared, and it is stored in the A solution chamber and the A dry powder bucket / bag for later use. In one application case, the above dissolution process can be interspersed in the self-test process of the hemodialysis equipment.

[0075] This invention proposes an online solution preparation method for A dry powder, employing variable-volume A-liquid chamber technology. The dissolution and preparation are not limited to the A dry powder container, allowing for smaller A dry powder containers or bags, facilitating transportation and storage, and meeting usage requirements. It also utilizes technologies for overall and one-time dissolution of the A dry powder, ensuring sufficient dissolution and qualified ion concentration, meeting the basic requirements for solution preparation. Furthermore, the use of variable-volume A-liquid chamber technology and circulating dissolution loop heating technology enables both thermal and chemical sterilization, shortening the sterilization time and meeting the basic requirements for clinical use. Finally, it employs water tank metering technology, providing a metering function to measure the amount of added reagents. The volume of water seepage meets the basic requirements for solution preparation, enabling precise preparation of solution A. Furthermore, it employs a dissolution sufficiency monitoring technology, combined with traditional conductivity detection technology and a dynamic algorithm, to effectively detect whether dissolution is complete. Air separation and degassing technologies are also used to meet the necessary degassing requirements during the dissolution of A dry powder. Hot water dissolution technology ensures a short dissolution time of less than 10 minutes for A dry powder, allowing for rapid deployment and meeting basic practical needs. Through the application of these technologies, A dry powder can be completely dissolved in a short time, effectively obtaining dialysate of accurate concentration and improving the reliability of solution preparation.

[0076] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

[0077] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. Furthermore, the described specific features, structures, materials, or characteristics may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of those different embodiments or examples.

[0078] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "a plurality of" means two or more, unless otherwise explicitly specified.

Claims

1. A dry powder inline liquid preparation device, characterized in that, include: The system includes a dry powder container module, a liquid container module, a water metering module, a heating module, a liquid detection module, a first solenoid valve group, a second solenoid valve group, a third solenoid valve group, a fourth solenoid valve group, a circulating power module, an overflow module, and a control circuit module. The top of the A dry powder containing module is connected to the bottom water channel of the A liquid containing module, the top of the A liquid containing module is connected to the water channel of the A liquid detection module, the A liquid detection module is connected to the water channel of the first solenoid valve group, the water volume metering module is connected to the water channels of the circulation power module, the overflow module, the first solenoid valve group and the second solenoid valve group respectively, the circulation power module is connected to the water channel of the heating module, the heating module is connected to the water channel of the overflow module, the overflow module is connected to the water channel of the third solenoid valve group, and the fourth solenoid valve group is connected to the bottom water channel of the third solenoid valve group and the A dry powder containing module respectively. The A dry powder containing module, the A liquid containing module, the water metering module, the heating module, the A liquid detection module, the first solenoid valve group, the second solenoid valve group, the third solenoid valve group, the fourth solenoid valve group, and the circulation power module are all electrically connected to the control circuit module. The control circuit module is used to receive the installation completion signal of the A dry powder containing module, to send control signals to control the A liquid containing module to change its volume, to receive the water level detection signal from the water metering module, to control the heating module to heat the liquid in the water circuit, to control the A liquid detection module to detect the liquid in the water circuit, to control the opening and closing of the first solenoid valve group, the second solenoid valve group, the third solenoid valve group, and the fourth solenoid valve group, and to control the circulation power module to transport the liquid in the water metering module to the heating module.

2. The A dry powder inline liquid preparation device as described in claim 1, characterized in that, The bottom and top of the A dry powder containing module are both wedge-shaped, and the bottom angle of the A dry powder containing module is smaller than the top angle; the bottom and top of the A liquid containing module are wedge-shaped.

3. The A dry powder inline liquid preparation device as described in claim 1, characterized in that, The volume of the A dry powder containing module is at least equal to a preset multiple of the A dry powder volume, and the volume of the A dry powder containing module is at most equal to the maximum volume of the A liquid containing module.

4. The A dry powder inline liquid preparation device as described in claim 1, characterized in that, The liquid A containment module includes: a soft cavity and two wall panels. The soft cavity is capable of changing its volume along a first direction. The two wall panels are parallel and spaced apart along the first direction. The soft cavity is disposed between the two wall panels and connected to the two wall panels.

5. The A dry powder inline liquid preparation device as described in claim 1, characterized in that, The overflow module includes: an air separation chamber and an overflow valve; the air separation chamber and the overflow valve are connected by a water circuit, the air separation chamber is connected by a water circuit to the heating module, and the overflow valve is connected by a water circuit to the water metering module; The air separation chamber is used to separate gas and liquid so that the gas is above the liquid; the overflow valve is used to overflow the gas and liquid to the water metering module when the water pressure in the air separation chamber is greater than the back pressure of the overflow valve.

6. The A dry powder inline liquid preparation device as described in claim 1, characterized in that, The water metering module is equipped with a float, and the water metering module has at least two detection positions, upper and lower, to detect the position of the float and obtain a water level detection signal; the top of the water metering module is equipped with an exhaust port and an air inlet.

7. A method for online preparation of dry powder A into a solution, characterized in that, An A dry powder inline liquid preparation device as described in any one of claims 1 to 6, comprising: Upon receiving the installation completion signal of the A dry powder containing module, select to enter the A liquid preparation mode; The system receives water level detection signals from the water metering module in real time. When the water level detection signal meets the preset metering requirements, it controls the second solenoid valve group to close and controls the circulating power module to transport the liquid in the water metering module to the heating module. The heating module is controlled to heat the liquid in the water circuit. When the liquid temperature in the water circuit meets the preset requirements, the third solenoid valve group and the fourth solenoid valve group are controlled to open, and the liquid is input from the bottom of the A dry powder receiving module to dissolve the A dry powder and obtain the A dry powder solution. The A dry powder dissolving solution is fed from the top of the A dry powder containing module to the bottom of the A liquid containing module, and then output from the top of the A liquid containing module. The A liquid detection module is controlled to sequentially perform conductivity and optical detection on the A dry powder solution output from the top of the A liquid containing module; The first solenoid valve group is controlled to open, and the A dry powder solution that has completed conductivity and optical detection is circulated and dissolved until the conductivity and optical detection analysis results of the A dry powder solution meet the preset solution preparation requirements and the number of times the A dry powder solution is circulated and dissolved meets the preset number of cycles requirement, thus determining that the A dry powder solution has met the preset solution preparation requirements.

8. The method for online preparation of dry powder A as described in claim 7, characterized in that, Also includes: The water metering module is equipped with a float. The water level in the water metering module is measured and detected by the number of float movements of the water metering module, and a water level detection signal is obtained. During the liquid circulation and dissolution process, when the water level detection signal result does not meet the preset measurement requirements, the second solenoid valve group is controlled to open; When the water level detection signal meets the preset metering requirements, the second solenoid valve group is controlled to close.

9. The method for online preparation of dry powder A as described in claim 7, characterized in that, The first solenoid valve group is controlled to open, and the A dry powder solution, after completing conductivity and optical detection, is circulated and dissolved until the conductivity and optical detection analysis results of the A dry powder solution both meet the preset solution preparation requirements and the number of circulations of the A dry powder solution meets the preset number of cycles requirement. This determines that the A dry powder solution has met the preset solution preparation requirements, including: The first solenoid valve group is controlled to open, and the A dry powder solution whose conductivity and optical detection and analysis results do not meet the preset requirements is transported to the water metering module through the bottom of the A liquid containing module; The circulating power module is controlled to transport the A dry powder solution in the water metering module to the heating module for heating and dissolution, so as to obtain the heated A dry powder solution. The third and fourth solenoid valve groups are controlled to open, so that the heated A dry powder dissolving solution is input from the bottom of the A dry powder containing module, and then output from the top of the A dry powder containing module and input from the bottom of the A liquid containing module into the A liquid containing module in sequence to complete one cycle of dissolution. The A-liquid detection module sequentially performs conductivity and optical detection on the A dry powder solution that has completed one cycle of dissolution and analyzes it. The above cycle dissolution steps are repeated until the conductivity and optical detection analysis results of the A dry powder solution meet the preset solution preparation requirements and the number of cycles of dissolution of the A dry powder solution meets the preset cycle number requirements, thus confirming that the A dry powder solution has met the preset solution preparation requirements.

10. A method for online preparation of dry powder A as described in any one of claims 7 to 9, characterized in that, Also includes: When the conductivity and optical detection analysis results of the A dry powder solution meet the preset solution preparation requirements, select to enter the A solution usage mode; After the A-liquid usage mode ends, the A-liquid container module is restored to its minimum volume state to disinfect the circulating water circuit and the A-liquid container module.

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