Microneedle device

Abstract

The microneedle device comprises a sleeve and a plurality of microneedle suites, the sleeve is provided with a hollow cavity, the hollow cavity penetrates through the two ends of the sleeve, the hollow cavity forms a push-in opening and a push-out opening in the two ends of the sleeve respectively, and the microneedle suites can be pushed into the hollow cavity from the push-in opening so as to be arranged in the hollow cavity in a stacked mode. And the microneedle suite can move in the hollow cavity along the sleeve to be pushed out from the push-out opening when being pushed. According to the microneedle device, after the microneedle suite located in the push-out opening is used, the microneedle suite located in the hollow cavity is pushed in the axial direction of the sleeve, so that the next microneedle suite is exposed out of the push-out opening, subsequent needle application operation is facilitated, and the needle application operation convenience is improved.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a microneedle device. Background Art

[0002] The stratum corneum is the main barrier of the skin, and some exogenous substances are difficult to penetrate into the skin. Microneedle treatment, also known as microneedle therapy, is a medical technology that uses fine needle-shaped instruments to implement mechanical or physical, minimally invasive damage stimulation on the skin soft tissue in order to obtain therapeutic or cosmetic effects. It can be accompanied by synchronous or step-by-step administration of drugs or functional ingredients, and the microneedles are used to improve their transdermal / absorption efficiency, thereby enhancing the therapeutic or cosmetic effects. The existing microneedle beauty instrument only has a single-function roller. As the roller rolls on the skin, the microneedles can form micropores on the skin or stimulate skin cells to start damage repair and regeneration effects, and there is no other auxiliary facial skin tissue repair or hydration effect. As a new type of physical penetration technology, soluble microneedles include micron-sized needle bodies solidified by active ingredients and soluble polymer substrates, which break through the stratum corneum barrier and form short-term reversible micropores in the skin. At the same time, the soluble polymer needle body absorbs body fluids and dissolves in the body, effectively releasing active ingredients and delivering them to the deep layers of the skin, which has received widespread attention and application.

[0003] In recent years, soluble microneedle products are generally monolithic structures. In order to keep the microneedles stably on the skin surface during use, an adhesive protective tape with a larger area than the microneedle array is usually covered on the microneedle array. When using, tear off the release paper on the adhesive tape, and then press the patch to the skin surface by hand. The adhesiveness of the protective tape keeps the patch in contact with the skin. Each time you apply it, you need to tear off the release paper and then apply it. Especially when applying to acne, spots, etc., you need to apply to multiple parts at one time. When using a patch with a smaller area, it is cumbersome and difficult to operate. Summary of the invention

[0004] Based on this, a microneedle device is provided to solve the problem of inconvenient needle operation.

[0005] The present application provides a microneedle device, comprising a sleeve and a plurality of microneedle kits, wherein the sleeve has a hollow cavity, the hollow cavity extends to both ends of the sleeve, the hollow cavity forms a push inlet and a push out outlet at both ends of the sleeve, respectively, a plurality of the microneedle kits can be pushed into the hollow cavity from the push inlet to be stacked in the hollow cavity, and the microneedle kits can move along the sleeve in the hollow cavity to be pushed out from the push out outlet when subjected to a thrust.

[0006] In one embodiment, a retaining ring is provided at the ejection port, and at least one of the retaining ring and the outer wall of the microneedle kit is elastic, and the retaining ring elastically abuts against the outer wall of the microneedle kit at the ejection port.

[0007] In one embodiment, the microneedle kit includes a needle seat and a microneedle module, the needle seat has a mounting surface, and the microneedle module is arranged on the mounting surface; the needle seat has a receiving groove, and the receiving groove is located on the side of the needle seat facing away from the mounting surface.

[0008] In one embodiment, the needle seat includes a base and a boss formed by the mounting surface protruding from the base, and the boss of the latter microneedle kit is received in the receiving groove of the former microneedle kit.

[0009] In one embodiment, the microneedle module includes a needle patch and a plurality of microneedles, wherein the plurality of microneedles are arranged in an array on the needle patch, and the needle patch is detachably connected to the mounting surface.

[0010] In one embodiment, the needle patch is bonded to the mounting surface by double-sided tape.

[0011] In one embodiment, the adhesive force between the double-sided adhesive tape and the needle seat is greater than the adhesive force between the double-sided adhesive tape and the needle patch.

[0012] In one embodiment, the microneedle module is fixedly connected to the needle seat.

[0013] In one embodiment, the microneedle kit includes a ring, which is detachably connected to the mounting surface, the height of the ring is greater than the height of the microneedles, and the plurality of microneedles are located in a space surrounded by the ring.

[0014] In one embodiment, the microneedle kit further comprises a sealing film, wherein the sealing film is bonded to an end of the ring away from the mounting surface.

[0015] In one of the embodiments, a protrusion is provided on the outer wall of the needle seat, and a groove is provided on the cavity wall of the hollow cavity. The protrusion matches with the groove, and the protrusion can move along the groove.

[0016] The above-mentioned microneedle device includes a sleeve and a plurality of microneedle kits, wherein the sleeve has a hollow cavity, and the hollow cavity penetrates to both ends of the sleeve to form a push-in port and a push-out port respectively at both ends of the sleeve, and the plurality of microneedle kits are stacked in the hollow cavity. Since the microneedle kit can move along the sleeve in the hollow cavity when subjected to a thrust, when using the microneedle device of the present application, after using the microneedle kit located at the push-out port, the microneedle kit located in the hollow cavity can be pushed along the axial direction of the sleeve to expose the next microneedle kit from the push-out port for subsequent needle application, thereby improving the convenience of needle application operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, drawings of other embodiments can be obtained based on these drawings without paying any creative work.

[0018] Figure 1 Schematic diagram of the structure of a microneedle device according to one embodiment of the present application.

[0019] Figure 2 Schematic diagram of the cross-sectional structure of a microneedle device according to one embodiment.

[0020] Figure 3 for Figure 2 An enlarged schematic diagram of the local structure of the microneedle device at the circled position is shown.

[0021] Figure 4 Schematic diagram of the three-dimensional structure of a sleeve of a microneedle device according to one embodiment.

[0022] Figure 5 for Figure 4 A schematic structural diagram of the sleeve of the microneedle device from another perspective is shown.

[0023] Figure 6 Schematic diagram of the structure of a microneedle kit of a microneedle device according to one embodiment.

[0024] Figure 7 FIG. 4 is a schematic cross-sectional structure diagram of a microneedle kit of a microneedle device according to one embodiment.

[0025] Figure 8 It is a schematic structural diagram of a microneedle kit of a microneedle device according to one embodiment when the collar and the sealing film are separated from the needle seat.

[0026] Fig. 9 It is a schematic structural diagram of a microneedle kit of a microneedle device according to one embodiment when a microneedle is separated from a needle seat.

[0027] Fig.10 This is a picture of the in vitro pig skin staining of the Example group in the soluble microneedle puncture experiment.

[0028] Fig.11 This is a picture of the in vitro pig skin staining of the control group in the soluble microneedle puncture experiment.

[0029] Reference numerals:

[0030] 100, microneedle device; 10, sleeve; 11, hollow cavity; 11a, groove; 12, push-in port; 13, push-out port; 14, retaining ring; 20, microneedle kit; 21, needle seat; 21a, mounting surface; 21b, protrusion; 21c, receiving groove; 211, base; 212, boss; 22, microneedle module; 22a, needle patch; 22b, double-sided tape; 22c, microneedle; 23, collar; 24, sealing film. DETAILED DESCRIPTION

[0031] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0032] In the embodiments of the present application, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0033] In this application, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0034] Combination Figures 1 to 3 As shown, a microneedle device 100 provided in one embodiment of the present application includes a sleeve 10 and a plurality of microneedle kits 20, wherein the sleeve 10 has a hollow cavity 11. The plurality of microneedle kits 20 are stacked in the hollow cavity 11, and the microneedle kits 20 can move along the sleeve 10 in the hollow cavity 11 when a thrust is applied. Figure 4 and Figure 5 As shown, the hollow cavity 11 penetrates to both ends of the sleeve 10 to form a push inlet 12 and a push out outlet 13 at both ends of the sleeve 10 respectively. The push inlet 12 is used to push the microneedle kit 20 into the hollow cavity 11; the push out outlet 13 is used to push the microneedle kit 20 located in the hollow cavity 11 out.

[0035] The microneedle device 100 of the present application can, after using the microneedle kit 20 located at the ejection port 13, push the microneedle kit 20 located in the hollow cavity 11 axially along the sleeve 10 to expose the next microneedle kit 20 from the ejection port 13 for subsequent needle placement operations, thereby improving the convenience of needle placement operations.

[0036] Combination Figure 3 and Figure 4 As shown, in some embodiments, a retaining ring 14 is provided at the push-out port 13, and at least one of the retaining ring 14 and the outer wall of the microneedle kit 20 is elastic, and the retaining ring 14 elastically abuts against the outer wall of the microneedle kit 20 located at the push-out port 13. In this embodiment, since at least one of the retaining ring 14 and the microneedle kit 20 is elastic and the two are elastically abutted, they can be deformed by force. In this way, when there is no force, the retaining ring 14 can prevent the microneedle kit 20 from falling from the push-out port 13; when a thrust is applied, the microneedle kit 20 can pass through the retaining ring 14 to be pushed out from the push-out port 13. Therefore, this structural setting not only meets the need for the microneedle kit 20 to be pushed out from the push-out port 13 to switch to the next microneedle kit 20, but also avoids the situation where the microneedle kit 20 falls off abnormally from the push-out port 13 by itself, so as to improve the reliability of the microneedle device 100.

[0037] It should be noted that, in some embodiments, when the microneedle kit 20 is loaded into the hollow cavity 11 from the push-in port 12, the microneedle kit 20 located in the hollow cavity 11 will be pushed along the axial direction of the sleeve 10 as a whole, so that the microneedle kit 20 closest to the push-out port 13 will be exposed from the push-out port 13. However, at this time, if the microneedle kit 20 is not pushed further, the microneedle kit 20 closest to the push-out port 13 will be limited by the retaining ring 14 and cannot easily fall from the push-out port 13.

[0038] When the microneedle device 100 of the embodiment of the present application is used for acupuncture, it is only necessary to hold the acupuncture side of the microneedle kit 20 of the sleeve 10 toward the acupuncture site, and use a stamp-like method to place the microneedle kit 20 located closest to the push-out port 13 against the skin of the acupuncture site, and the acupuncture operation can be completed, which is simple and light. Specifically, when using the microneedle device 100, the microneedle kit 20 closest to the push-out port 13 (i.e., the microneedle kit 20 exposed from the push-out port 13) can be used to perform acupuncture on the skin first, and then, when it is necessary to replace the next microneedle kit 20 for acupuncture, the microneedle kit 20 located at the push-out port 13 can be pulled out from the push-out port 13. It is understandable that during the pulling-out process, the microneedle kit 20 overcomes the obstruction of the retaining ring 14. After the microneedle kit 20 is pulled out of the push-out port 13, the retaining ring 14 can continue to have a blocking effect on the next microneedle kit 20. In some embodiments, the microneedle kit 20 can be pushed into the push port 12 to apply a thrust, so that the microneedle kit 20 located in the hollow cavity 11 is pushed along the axial direction of the sleeve 10 and moves as a whole toward the push port 13. In this way, the microneedle kit 20 closest to the push port 13 is exposed from the push port 13 to continue the subsequent needle application operation.

[0039] Combination Figure 3 and Figure 6 As shown, in some embodiments, the microneedle kit 20 includes a needle holder 21 and a microneedle module 22. The microneedle module 22 is detachably connected to the needle holder 21. In this way, when performing acupuncture, the push-out port 13 of the microneedle device 100 is directed toward the skin of the acupuncture site, so that the microneedle module 22 in the microneedle kit 20 exposed from the push-out port 13 can puncture the skin of the acupuncture site during the application process. After the acupuncture is completed, the sleeve 10 can be removed, so that the needle holder 21 and the microneedle module 22 in the microneedle kit 20 located at the push-out port 13 are separated. Specifically, the microneedle module 22 remains at the acupuncture site, and the needle holder 21 will not easily fall off from the push-out port 13 under the obstruction of the retaining ring 14, so that the needle holder 21 is separated from the microneedle module 22. Before the next microneedle kit 20 is used, a force can be applied to the needle seat 21 to overcome the blocking force of the retaining ring 14 and pull the needle seat 21 out of the ejection port 13. At this time, a thrust can be applied to the microneedle kit 20 located in the hollow cavity 11, so that the microneedle module 22 of the next microneedle kit 20 is exposed from the ejection port 13 for subsequent needle application operations.

[0040] In some embodiments, the needle holder 21 has a mounting surface 21a. The microneedle module 22 is disposed on the mounting surface 21a. Figure 3 , Figure 6 and Figure 7As shown, the needle seat 21 has a receiving groove 21c, and the receiving groove 21c is located on the side of the needle seat 21 facing away from the mounting surface 21a. Therefore, when multiple needle seats 21 are stacked in the hollow cavity 11, the receiving groove 21c can receive the microneedle module 22 on the adjacent needle seat 21, thereby preventing the microneedle module 22 from being squeezed. Figure 6 As shown, the needle seat 21 includes a base 211 and a mounting surface 21a protruding from the base 211 to form a boss 212, so that when the microneedle kit 20 is exposed from the ejection port 13, the boss 212 can extend out of the ejection port 13, so as to facilitate the microneedle module 22 on the boss 212 to perform an injection operation on the injection site.

[0041] See also Figure 3 As shown, the boss 212 of the subsequent microneedle kit 20 is received in the receiving groove 21c of the previous microneedle kit 20, so that multiple microneedle kits 20 are compactly received in the hollow cavity 11 while preventing the microneedle module 22 from being squeezed. It should be noted that the previous microneedle kit 20 and the subsequent microneedle kit 20 are referred to in terms of their positions in the hollow cavity 11. Specifically, of any two adjacent microneedle kits 20 in the hollow cavity 11, the microneedle kit 20 closer to the ejection port 13 is the previous microneedle kit 20, and the microneedle kit 20 farther from the ejection port 13 is the subsequent microneedle kit 20.

[0042] The mounting surface 21a is a plane, and the needle body of the microneedle module 22 is arranged perpendicular to the mounting surface 21a. In order to facilitate the acupuncture process, the mounting surface 21a of the needle holder 21 fits with the skin of the acupuncture site to ensure that the microneedle module 22 has a good puncture effect on the skin. Specifically, since the needle body of the microneedle module 22 is arranged perpendicular to the mounting surface 21a, when the microneedle module 22 punctures, the needle body vertically penetrates the skin to improve the puncture effect. In the conventional technology, since the skin is soft and easily deformed by pressing, when the microneedle patch (i.e., the needle patch 22a provided with the microneedle module 22) is pressed against the skin, it is difficult to ensure that the patch remains horizontal by only pressing the microneedle patch with fingers, and the needle body cannot penetrate vertically into the skin, affecting the penetration efficiency of the microneedle module 22.

[0043] Combination Figures 4 to 6As shown, in some embodiments, the cavity wall of the hollow cavity 11 (i.e., the inner wall of the sleeve 10) is provided with a groove 11a, and the outer wall of the needle seat 21 is provided with a protrusion 21b. The protrusion 21b matches the groove 11a, and the protrusion 21b can move along the groove 11a. The microneedle kit 20 can move along the groove 11a and rely on the friction between the protrusion 21b and the side wall of the groove 11a to achieve a fixed effect. Only when the thrust is large enough to overcome the friction, the microneedle kit 20 is pushed along the hollow cavity 11 to emerge from the ejection port 13. The needle seat 21 can be made of a slightly elastic material such as plastic, so that when it is pushed through the retaining ring 14, it will be squeezed and deformed by the retaining ring 14, thereby passing through the retaining ring 14. When the next microneedle kit 20 emerges from the ejection port 13 , the blocking resistance of the retaining ring 14 on the needle seat 21 can be utilized to prevent the microneedle kit 20 from falling off from the ejection port 13 . The needle seat 21 can only pass through the retaining ring 14 and be ejected from the ejection port 13 when the thrust causes the needle seat 21 to be squeezed and deformed.

[0044] In some embodiments, the number of the grooves 11a and the protrusions 21b can be multiple, for example, four grooves 11a and four protrusions 21b are correspondingly arranged. Of course, in some embodiments, the number of the grooves 11a and the protrusions 21b can also be 2 or 3, which is not limited here.

[0045] Combination Figure 7 As shown, in some embodiments, the microneedle module 22 includes a needle patch 22a and a plurality of microneedles 22c, and the plurality of microneedles 22c are arranged in an array on the needle patch 22a. The needle patch 22a is used to adhere to the skin, so that the microneedles 22c keep stimulating the skin to improve the therapeutic effect.

[0046] It should be noted that the needle patch 22 a is detachably connected to the mounting surface 21 a , so that the microneedle module 22 can be separated from the needle seat 21 .

[0047] For example, the needle patch 22a can be detachably connected to the mounting surface 21a through the double-sided adhesive 22b, so that the plurality of microneedle modules 22 can be separated from the needle seat 21. The viscosity of the double-sided adhesive 22b is not limited here. In some embodiments, the adhesive force between the double-sided adhesive 22b and the needle seat 21 is greater than the adhesive force between the double-sided adhesive 22b and the needle patch 22a, so that the needle seat 21 adheres to the double-sided adhesive 22b and is separated from the needle patch 22a.

[0048] It should be noted that the adhesion of the needle patch 22a is greater than the adhesion between the double-sided tape 22b and the needle patch 22a. Therefore, when the needle patch 22a is adhered to the skin of the acupuncture site, the adhesion stability of the needle patch 22a to the skin can be ensured during the process of separating the needle patch 22a from the double-sided tape 22b, thereby improving the application effect.

[0049] The microneedle module 22 is not limited to being detachably connected to the needle seat 21. In some embodiments, multiple microneedle modules 22 may also be fixed to the needle seat 21, so that multiple parts can be punctured continuously, or the same part can be punctured multiple times. The fixing method of the microneedle module 22 and the needle seat 21 includes but is not limited to connecting the needle patch 22a provided with multiple microneedle modules 22 to the needle seat 21 through a highly viscous glue, so that the microneedle module 22 is not easy to fall off from the needle seat 21. It can be understood that the microneedle module 22 can also be fixed to the needle seat 21 during the injection molding process of the needle seat 21, and the connection method between the microneedle module 22 and the needle seat 21 is not limited here.

[0050] Combination Figure 7 and Figure 8 As shown, the microneedle kit 20 includes a collar 23, which is detachably connected to the mounting surface 21a, and the height of the collar 23 is greater than the height of the microneedle module 22. A plurality of microneedle modules 22 are located in the space surrounded by the collar 23, so that the collar 23 can be used to protect the microneedle module 22. When in use, it is only necessary to remove the collar 23 from the mounting surface 21a. The material of the collar 23 can be plastic or rubber, which is not limited here. The collar 23 can be detachably connected to the needle seat 21 by means of glue, or it can be detachably connected to the needle seat 21 by means of snaps or threads, which is not limited here.

[0051] The inventors have found that the material of the soluble microneedle module 22 is easily soluble in water and has strong hygroscopicity. During storage, such as exposure to a humid environment, or when using the release paper to tear off by hand or holding the application, it is easy to accidentally touch the needle body, causing the needle body to be damaged, dissolved or deformed, or contaminated, which will affect the penetration performance and safety of the microneedle module 22.

[0052] Based on this, the soluble microneedle module 22 of the embodiment of the present application is loaded during needle application. Figure 7 and Figure 8 As shown, the microneedle kit 20 also includes a sealing film 24, which is bonded to the end of the ring 23 away from the mounting surface 21a, so that the sealing film 24 and the ring 23 are used together to seal and protect the multiple microneedle modules 22 surrounded by the ring 23, so that each microneedle kit 20 is independently packaged to prevent the microneedle module 22 from being contaminated, and also to prevent the microneedle module 22 from absorbing water vapor and becoming ineffective.

[0053] Combination Figure 8As shown, when using the microneedle device 100, the sealing film 24 and the collar 23 are peeled off, and the sleeve 10 can be held in hand to puncture the skin of the needle application site with the microneedle module 22 exposed at the ejection port 13, just like stamping. After pressing for a certain period of time, the sleeve 10 can be removed, which improves the convenience of operation. The sealing film 24 and the collar 23 can be peeled off together, or the sealing film 24 can be peeled off from the collar 23, and then the collar 23 can be peeled off from the mounting surface 21a of the needle seat 21.

[0054] Combination Fig. 9 As shown, in the embodiment where the plurality of microneedle modules 22 are detachably connected to the needle holder 21, as the sleeve 10 is removed, the plurality of microneedle modules 22 will automatically separate from the needle holder 21, and at this time, the microneedle module 22 is attached to the skin. Then, the needle holder 21 can be pulled out from the push-out port 13. In some embodiments, the needle holder 21 of the used microneedle kit 20 can be pushed into the hollow cavity 11 of the sleeve 10 again from the push-out port 12 to expose the microneedle kit 20 closest to the push-out port 13 from the push-out port 13. This can be repeated to conveniently use multiple microneedle kits 20 for acupuncture, which is convenient and reliable to use.

[0055] It should be noted that the microneedle module 22 in the embodiment of the present application may be a soluble microneedle module 22 patch, so that the microneedle module 22 pierced into the skin dissolves in the body after absorbing body fluids to safely and effectively release the active ingredients.

[0056] Next, a penetration test was performed on in vitro stained pig skin using the microneedle device 100 provided in the embodiment of the present application to analyze the application performance of different methods.

[0057] Among them, the test used the same model of soluble blue dye microneedle module 22.

[0058] The specific parameters of the microneedle module 22 are as follows:

[0059] Microneedle ingredients Blue dye and sodium hyaluronate Needle length 290μm Patch size Diameter 1cm Needle peel strength 1.0N / cm Double-sided adhesive peel strength 0.1N / cm

[0060] Example group: When using the microneedle device 100 provided by the present application for patching, first, tear off the sealing film 24 on the microneedle module 22, and then press the head of the beauty instrument assembled with the microneedle module 22 vertically on the ex vivo pig skin in a stamp-like manner, and then lift the beauty instrument after pressing, and the microneedle patch automatically detaches from the microneedle module 22 and sticks to the ex vivo pig skin to complete the patching process. Install the used microneedle module 22 from the tail of the beauty instrument, and push out the next microneedle module 22. Repeat the same method to complete the patching at 3-5 different parts.

[0061] Control group: The microneedle device 100 of the present application was not used, and the same microneedle patch was directly pressed on the ex vivo pig skin with fingers to complete the application.

[0062] After 15 minutes of application, the microneedle module 22 was removed from both the example group and the control group, and the skin surface was cleaned and photographed for observation. The needle penetration efficiency was evaluated by the array of dyeing on the pig skin.

[0063] Combination Fig.10 and Fig.11 As shown, Fig.10 The picture showing the in vitro pig skin staining of the Example group is shown. Fig.11 The picture of the in vitro pig skin staining of the control group is shown. By observing the successful penetration of the microneedle module 22 into the skin in the two groups, it can be understood that the penetration rate of the microneedle device 100 provided in the embodiment of the present application is significantly improved compared with the control group. It should be noted here that the model substance blue dye will be released after dissolving in the skin, and the penetration rate can be calculated based on the number of blue dots and the number of needles in the microneedle module 22. Fig.11 As shown, the penetration rate of the control group was 40%. Fig.10 As shown, in the ex vivo pig skin of the embodiment group, the blue dots correspond to the microneedle array, and the penetration rate is above 95%, which significantly improves the penetration rate.

[0064] In addition, by statistically analyzing the time taken for the patching operation of the embodiment group and the control group, it can be found that the embodiment group using the microneedle device 100 of the present application for the patching operation has the advantages of short time consumption and high patching efficiency compared with the control group. Specifically, the control group takes 10 minutes to complete the patching operation of 3-5 parts; while the embodiment group only takes 2 minutes to complete the patching operation of 3-5 parts, so the microneedle device 100 provided by the embodiment of the present application can improve the efficiency of acupuncture and shorten the required time.

[0065] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0066] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several modifications and improvements can be made without departing from the inventive concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A microneedle device, characterized in that: The invention comprises a sleeve and a plurality of microneedle kits, wherein the sleeve has a hollow cavity, the hollow cavity extends to both ends of the sleeve, the hollow cavity forms a push inlet and a push out outlet at both ends of the sleeve respectively, and the plurality of microneedle kits can be pushed into the hollow cavity from the push inlet so as to be stacked in the hollow cavity, and the microneedle kits can move along the sleeve in the hollow cavity to be pushed out from the push out outlet when subjected to a thrust.

2. The microneedle device according to claim 1, characterized in that A retaining ring is provided at the ejection port, and at least one of the retaining ring and the outer wall of the microneedle kit is elastic. The retaining ring elastically abuts against the outer wall of the microneedle kit located at the ejection port.

3. The microneedle device according to claim 2, characterized in that The microneedle kit comprises a needle seat and a microneedle module, wherein the needle seat has a mounting surface, and the microneedle module is arranged on the mounting surface; the needle seat has a receiving groove, and the receiving groove is located on a side of the needle seat that is away from the mounting surface.

4. The microneedle device according to claim 3, characterized in that The needle seat comprises a base and a boss formed by the mounting surface protruding from the base, and the boss of the latter microneedle kit is received in the receiving groove of the former microneedle kit.

5. The microneedle device according to claim 3, characterized in that The microneedle module comprises a needle patch and a plurality of microneedles, wherein the plurality of microneedles are arranged in an array on the needle patch, and the needle patch is detachably connected to the mounting surface.

6. The microneedle device according to claim 5, characterized in that The needle patch is bonded to the mounting surface via double-sided adhesive.

7. The microneedle device according to claim 6, characterized in that The adhesive force between the double-sided adhesive tape and the needle seat is greater than the adhesive force between the double-sided adhesive tape and the needle patch.

8. The microneedle device according to claim 3, characterized in that The microneedle module is fixedly connected to the needle seat.

9. The microneedle device according to claim 3, characterized in that The microneedle kit comprises a ring which is detachably connected to the mounting surface. The height of the ring is greater than the height of the microneedles. The plurality of microneedles are located in a space surrounded by the ring.

10. The microneedle device according to claim 9, characterized in that The microneedle kit further comprises a sealing film, which is bonded to an end of the ring away from the mounting surface.

11. The microneedle device according to claim 3, characterized in that The outer wall of the needle seat is provided with a protrusion, and the cavity wall of the hollow cavity is provided with a groove. The protrusion matches with the groove, and the protrusion can move along the groove.

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