Chromatographic screen cleaning method

Abstract

A chromatography screen cleaning method comprises the steps that a screen is fixed to a screen positioning assembly in a cleaning container; a cleaning agent for pickling is added into the cleaning container to remove oxide skin and rust on the surface of the screen, and in the pickling process, a stirring device above the screen positioning assembly rotates to stir the cleaning agent; waste liquid is discharged from the cleaning container, and purified water is added into the cleaning container for flushing; a cleaning agent for salt washing is added into the cleaning container to remove free impurities attached to the screen, and in the salt washing process, the stirring device rotates to stir the cleaning agent; waste liquid is discharged from the cleaning container, and purified water is added into the cleaning container for flushing; a cleaning agent for alkali washing is added into the cleaning container to remove fat-soluble substances attached to the screen, and in the alkali washing process, the stirring device rotates to stir the cleaning agent; waste liquid is discharged from the cleaning container, and purified water is added into the cleaning container for flushing. The cleaning device has the advantages of being high in cleaning efficiency, beneficial to reducing the probability of rusting and blocking after cleaning and the like.

Description

Technical Field

[0001] The invention relates to a cleaning method, in particular to a chromatography screen cleaning method. Background Art

[0002] Stainless steel mesh used for chromatography in the field of bioengineering and stainless steel mesh with similar filtering requirements, the powder generated during cutting and forming, the impurity particles, grease and other substances attached to the mesh during transportation are the main causes of rust or blockage of the mesh. In addition, the welds of the welded mesh and the narrow gaps (generally no more than 0.5 mm in width) naturally formed after the mesh is welded with the inner and outer rings are very prone to rust, and rust can easily lead to protein inactivation. Substances containing free chloride ions (such as NaCl) used in the chromatography process can easily cause free metal powders and metal chips to oxidize and rust. In addition, the porous and multi-layered characteristics of the mesh make it easy for the mesh to be blocked, especially when used to separate liquids with high viscosity, so the mesh needs to be cleaned.

[0003] In the existing chromatography screen cleaning technology, the screen is generally washed by direct immersion combined with a high-pressure water gun. When the direct immersion method is used, the screen and the cleaning liquid are always in a relatively static state, and bubbles are easily formed in the micro-gap. The bubbles will hinder the immersion effect, and the high-pressure water gun cannot directly wash away the metal powder and metal chips. As a result, the screen is more likely to rust after cleaning, and the screen clogging problem has not been effectively improved. In addition, the existing cleaning technology has low compatibility, and only a small amount of screens can be cleaned in each batch, and the cleaning efficiency is too low. Summary of the invention

[0004] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a chromatography screen cleaning method which has high cleaning efficiency and is beneficial to reducing the probability of rust and blockage after cleaning.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0006] A chromatography screen cleaning method comprises the following steps:

[0007] Fixing the screen to the screen positioning assembly in the cleaning container;

[0008] A cleaning agent for pickling is added to the cleaning container to remove the oxide scale and rust on the surface of the screen. During the pickling process, the stirring device above the screen positioning assembly rotates to stir the cleaning liquid;

[0009] The cleaning container is drained to discharge the waste liquid, and then purified water is added to the cleaning container for rinsing;

[0010] A cleaning agent for salt washing is added to the cleaning container to remove free impurities attached to the screen. During the salt washing process, the stirring device rotates to stir the cleaning liquid;

[0011] The cleaning container is drained to discharge the waste liquid, and then purified water is added to the cleaning container for rinsing;

[0012] A cleaning agent for alkaline washing is added to the cleaning container to remove fat-soluble substances attached to the screen. During the alkaline washing process, the stirring device rotates to stir the cleaning liquid;

[0013] The cleaning container is drained to remove the waste liquid, and then purified water is added to the cleaning container for rinsing.

[0014] As a further improvement of the above technical solution: the cleaning agent used for pickling is 1-2 mol / L acetic acid, and the cleaning time is 2-5 hours.

[0015] As a further improvement of the above technical solution: the cleaning agent used for salt washing is 1-3 mol / L sodium chloride, and the cleaning time is 0.5-2h.

[0016] As a further improvement of the above technical solution: the cleaning agent used for alkaline cleaning is 0.5-2 mol / L sodium hydroxide, and the cleaning time is 0.5-2h.

[0017] As a further improvement of the above technical solution: the rinsing time after acid washing is 3 to 20 minutes, the rinsing time after salt washing is 3 to 20 minutes; and the rinsing time after alkali washing is 5 to 25 minutes.

[0018] As a further improvement of the above technical solution: after acid washing and salt washing, the conductivity value of the screen is detected to be less than 10μS / cm, and then washing is stopped;

[0019] After alkaline washing, stop washing when the conductivity value of the screen returns to zero.

[0020] As a further improvement of the above technical solution: the stirring device is connected to the stirring drive member, the stirring drive member is arranged on the mounting seat, the mounting seat is arranged on the bracket, and the bracket is provided with a lifting drive member for driving the mounting seat to rise and fall and a lifting guide rail for providing guidance for the mounting seat.

[0021] As a further improvement of the above technical solution: the screen positioning assembly includes a base, at least one positioning screw is provided on the base, a plurality of positioning blocks are provided on the outer periphery of the positioning screw and a locking block is threadedly connected to the upper end, a first positioning portion and a first flange located above the first positioning portion are provided on the positioning block, a second positioning portion and a second flange located above the second positioning portion are provided on the locking block, the screen and the isolation pad are provided on the outer periphery of the first positioning portion and the second positioning portion, the diameter of the isolation pad is larger than the diameter of the first positioning portion and the second positioning portion, the uppermost screen is clamped between the second flange and the adjacent isolation pad, and the remaining screens are clamped between the first flange and the isolation pad below.

[0022] As a further improvement of the above technical solution: a plurality of adjustment blocks are provided on the base, and the adjustment blocks are threadedly connected to the base;

[0023] And / or, a concave-convex positioning structure is provided between two upper and lower adjacent positioning blocks, and a concave-convex positioning structure is also provided between the locking block and the adjacent positioning block.

[0024] As a further improvement of the above technical solution: a cover plate is provided on the top of the cleaning container, a channel for the stirring device to pass through is provided on the cover plate, and a drain valve is provided at the bottom of the cleaning container.

[0025] Compared with the prior art, the advantages of the present invention are as follows: the chromatography screen cleaning method disclosed in the present invention can fix multiple models and / or multiple screens on the screen positioning assembly at one time, which is beneficial to improving the cleaning efficiency; in the specific operation, pickling is first performed to mainly remove the oxide scale and rust (mainly Fe2O3, Fe3O4) on the surface of the screen, and the product after the reaction is mainly ferric acetate (Fe 3+ ), ferrous acetate (Fe 2+ ), and the reactants are all soluble in water, so the purpose of removing oxide scale and rust can be achieved; then salt washing is carried out, mainly to remove free impurities attached to the screen (mainly Fe2O3 that is not completely dissolved or detached by acid washing), and the product after the reaction is mainly ferric chloride (Fe 3+ ), ferrous chloride (Fe 2+), in this process, the salt washing cleaning agent acts as a strong electrolyte, which accelerates the rusting of free impurities and consumes the free impurities in the reaction, so as to achieve the purpose of removing free impurities; finally, alkaline washing is performed, which is mainly used to remove oil, fat, protein and other fat-soluble substances on the metal surface, and prevent the screen from being blocked; during each cleaning process, the cleaning liquid is stirred by the stirring device above to form a vortex, which can disperse and destroy the bubbles between the micro gaps, and the gaps are continuously flushed, greatly reducing the possibility of rusting again due to insufficient cleaning, while flushing away tiny particles, removing grease, and preventing the screen from being blocked; after each cleaning, it is rinsed with purified water, which is beneficial to prevent the cleaning agent from remaining in the screen, avoid the screen from being eroded by the cleaning agent, and ensure the cleaning effect of the next cleaning step.

[0026] Other features and advantages of the present invention will be described in detail in the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 The present invention is a schematic diagram of the three-dimensional structure of the screen cleaning device.

[0028] Figure 2 The invention discloses a cross-sectional structural diagram of a screen cleaning device.

[0029] Figure 3 It is a schematic diagram of the three-dimensional structure of the upper part of the first embodiment of the screen positioning assembly involved in the present invention.

[0030] Figure 4 It is a three-dimensional structural schematic diagram of the lower part of an embodiment of a screen positioning assembly involved in the present invention.

[0031] Figure 5 It is a schematic diagram of the three-dimensional structure of the upper part of the second embodiment of the screen positioning assembly in the present invention.

[0032] Figure 6 It is a schematic diagram of the three-dimensional structure of the lower part of the second embodiment of the screen positioning assembly involved in the present invention.

[0033] Figure 7 It is a schematic diagram of the three-dimensional structure of the upper part of the third embodiment of the screen positioning assembly involved in the present invention.

[0034] Figure 8 It is a schematic diagram of the three-dimensional structure of the lower part of the third embodiment of the screen positioning assembly involved in the present invention.

[0035] Fig. 9 It is a schematic diagram of the main structure of the screen positioning assembly embodiment 3 of the present invention.

[0036] Fig.10 It is a main cross-sectional structural schematic diagram of Embodiment 3 of the screen positioning assembly involved in the present invention.

[0037] The symbols in the figure represent:

[0038] 1. Cleaning container; 11. Cover; 12. Channel; 13. Drain valve; 2. Bracket; 21. Mounting seat; 22. Lifting drive; 23. Lifting guide rail; 3. Screen; 4. Screen positioning assembly; 41. Base; 42. Positioning screw; 43. Adjustment block; 44. Positioning block; 441. First positioning portion; 442. First flange; 45. Locking block; 451. Second positioning portion; 452. Second flange; 46. Isolation pad; 5. Agitation device; 51. Agitation drive; 6. Roller. DETAILED DESCRIPTION

[0039] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0040] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0041] In the present invention, unless otherwise clearly specified and limited, the terms "assemble", "connect", "connect", "fix" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0042] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0043] like Figures 1 to 10 As shown, the chromatography screen cleaning method of this embodiment comprises the following steps:

[0044] Fixing the screen 3 on the screen positioning assembly 4 in the cleaning container 1;

[0045] A cleaning agent for pickling is added to the cleaning container 1 to remove the oxide scale and rust on the surface of the screen 3. During the pickling process, the stirring device 5 above the screen positioning assembly 4 rotates to stir the cleaning liquid;

[0046] The cleaning container 1 is drained to discharge the waste liquid, and then purified water is added to the cleaning container 1 for rinsing;

[0047] A cleaning agent for salt washing is added to the cleaning container 1 to remove free impurities attached to the screen 3. During the salt washing process, the stirring device 5 rotates to stir the cleaning liquid;

[0048] The cleaning container 1 is drained to discharge the waste liquid, and then purified water is added to the cleaning container 1 for rinsing;

[0049] A cleaning agent for alkaline washing is added to the cleaning container 1 to remove fat-soluble substances attached to the screen 3. During the alkaline washing process, the stirring device 5 rotates to stir the cleaning liquid;

[0050] The cleaning container 1 is drained to discharge the waste liquid, and then purified water is added to the cleaning container 1 for flushing.

[0051] The chromatography screen cleaning method of this embodiment can fix multiple types and / or multiple screens 3 on the screen positioning component 4 at one time ( Figure 3 and Figure 4 Four groups of screens 3 of the same model are fixed on the screen positioning assembly 4; Figure 5 and Figure 6 A group of screens 3 of the same model are fixed on a screen positioning assembly 4; Figure 7 and Figure 8 Two groups of different types of screens 3 are fixed on the screen positioning assembly 4), which is beneficial to improve the cleaning efficiency; in the specific operation, pickling is first performed to remove the oxide scale and rust (mainly Fe2O3, Fe3O4) on the surface of the screen 3. The product after the reaction is mainly ferric acetate (Fe 3+ ), ferrous acetate (Fe 2+ ), and the reactants are all soluble in water, so the purpose of removing oxide scale and rust can be achieved; then salt washing is carried out, mainly to remove free impurities attached to the screen 3 (mainly Fe2O3 that is not completely dissolved or detached by acid washing), and the product after the reaction is mainly ferric chloride (Fe 3+ ), ferrous chloride (Fe 2+), in this process, the salt washing cleaning agent acts as a strong electrolyte, which accelerates the rusting of free impurities and consumes the free impurities in the reaction, so as to achieve the purpose of removing free impurities; finally, alkaline washing is performed, which is mainly to remove oil, fat, protein and other fat-soluble substances on the metal surface of the screen 3, and prevent the screen 3 from being blocked; during each cleaning process, the stirring device 5 above is used to stir the cleaning liquid to form a vortex, which can disperse and destroy the bubbles between the micro gaps, and allow the gaps to be continuously flushed, greatly reducing the possibility of rusting again due to insufficient cleaning (experiments show that the probability of rusting again after cleaning is reduced to less than 5%), and at the same time flushing away tiny particles, removing grease, and preventing the screen 5 from being blocked; after each cleaning, flushing with purified water is beneficial to prevent the cleaning agent from remaining in the screen 5, avoiding the screen 5 from being eroded by the cleaning agent, and ensuring the cleaning effect of the next cleaning step.

[0052] As a preferred embodiment, the cleaning agent for pickling is 1-2 mol / L acetic acid, and the cleaning time is 2-5 hours, which is conducive to ensuring the effect of removing oxide scale and rust. Since this process reacts relatively slowly, the pickling time is relatively long. Further preferably, the cleaning agent for pickling is 1.5 mol / L acetic acid, and the cleaning time is 3 hours.

[0053] As a preferred embodiment, the cleaning agent for salt washing is 1-3 mol / L sodium chloride, and the cleaning time is 0.5-2 hours. Sodium chloride, as a strong electrolyte, can accelerate the rusting of free impurities, so that the free impurities are consumed in the reaction, which is conducive to ensuring the effect of removing free impurities. Further preferably, the cleaning agent for salt washing is 2 mol / L sodium chloride, and the cleaning time is 1 hour.

[0054] As a preferred embodiment, the cleaning agent for alkaline washing is 0.5-2 mol / L sodium hydroxide, and the cleaning time is 0.5-2 hours, which is conducive to removing fat-soluble substances such as oil, fat and protein on the metal surface of the screen 3. Further preferably, the cleaning agent for alkaline washing is 1 mol / L sodium hydroxide, and the cleaning time is 1 hour.

[0055] As a preferred embodiment, the rinsing time after acid washing is 3 to 20 minutes, the rinsing time after salt washing is 3 to 20 minutes, and the rinsing time after alkali washing is 5 to 25 minutes. By fully rinsing, it is ensured as much as possible that the cleaning agent does not remain in the screen 3, and the screen 3 is prevented from being eroded by the cleaning agent, while ensuring the cleaning effect of the next step of cleaning. Further preferably, the rinsing time after acid washing is 5 to 10 minutes, the rinsing time after salt washing is 5 to 10 minutes, and the rinsing time after alkali washing is 8 to 12 minutes, taking into account both the rinsing effect and the cleaning efficiency.

[0056] As a preferred embodiment, after pickling and salt washing, the conductivity value κ of the screen 3 is detected to be less than 10 μS / cm, and then the washing is stopped, indicating that the washing of the screen 3 after pickling and salt washing meets the requirements;

[0057] After the alkali washing, the conductivity value of the screen 3 is detected to be zero and then the washing is stopped, indicating that the washing after the alkali washing ensures that there is basically no detergent residue in the screen 3, the operation is simple, and the detection is reliable.

[0058] See Figure 1 and Figure 2 In this embodiment, the stirring device 5 is connected to the stirring driving member 51, and the stirring driving member 51 is arranged on the mounting seat 21, and the mounting seat 21 is arranged on the bracket 2. The bracket 2 is provided with a lifting driving member 22 for driving the mounting seat 21 to rise and fall, and a lifting guide rail 23 for providing guidance for the mounting seat 21. During operation, the lifting driving member 22 can be used to drive the mounting seat 21 and the stirring device 5 to rise and fall as a whole, so that the stirring device 5 can enter and exit the cleaning container 1, and at the same time, the distance between the stirring device 5 and the screen 3 below can be adjusted to ensure the cleaning effect. The lifting guide rail 23 provides a guiding function for the lifting and lowering movement of the mounting seat 21, ensuring that the lifting and lowering movement process is stable and smooth to avoid deviation; after the stirring device 5 is in place, the stirring driving member 51 drives the stirring device 5 to rotate, and the cleaning liquid is stirred up to form a vortex, and the structure is reasonable and effective. Preferably, the stirring drive member 51 adopts a pneumatic motor and the lifting drive member 22 adopts a cylinder. The two can share the air source to save the cost of the cleaning equipment. Of course, in other embodiments, the two can also adopt motors, cylinders, etc. respectively, which will not be repeated here; and the cleaning container 1 can be a cleaning bucket, a cleaning tank or a box, etc., and rollers are installed at the bottom of the cleaning container 1 and the bracket 2 for more convenient movement; the stirring device 5 can be a stirring blade, etc.

[0059] Participate specifically Fig. 9 and Fig.10In this embodiment, the screen positioning assembly 4 includes a base 41, at least one positioning screw 42 is provided on the base 41, a plurality of positioning blocks 44 are sleeved on the outer periphery of the positioning screw 42, and a locking block 45 is threadedly connected to the upper end, a first positioning portion 441 and a first flange 442 located above the first positioning portion 441 are provided on the positioning block 44, a second positioning portion 451 and a second flange 452 located above the second positioning portion 451 are provided on the locking block 45, a screen 3 and an isolation pad 46 are sleeved on the outer periphery of the first positioning portion 441 and the second positioning portion 451, the diameter of the isolation pad 46 is larger than the diameter of the first positioning portion 441 and the second positioning portion 451, and the uppermost screen 3 It is clamped between the second flange 452 and the adjacent isolation pad 46, and the remaining screens 3 are clamped between the first flange 442 and the isolation pad 46 below, so that each layer of screen 3 can be fixed on the base 41 and maintain a set gap. The isolation pad 46 provides support for the screen 3, so that each layer of screen 3 can be cleaned while preventing damage, and the screen 3 can be easily installed and disassembled (after loosening the locking block 45, the screen 3, isolation pad 46 and positioning block 44 can be taken out from top to bottom in turn; the installation process is the opposite, first install the isolation pad 46, screen 3 and positioning block 44 on the positioning screw 42 in turn from bottom to top, and finally tighten the locking block 45).

[0060] Furthermore, in this embodiment, a plurality of adjustment blocks 43 are provided on the base 41, and the adjustment blocks 43 are threadedly connected to the base 41. By rotating each adjustment block 43 separately, the base 41 can be conveniently adjusted to a horizontal state, which has a simple structure and is convenient to adjust.

[0061] A concave-convex positioning structure is provided between the two adjacent positioning blocks 44, and a concave-convex positioning structure is also provided between the locking block 45 and the adjacent positioning block 44, which is conducive to achieving positioning between each positioning block 44 and between the positioning block 45 and the locking block 45, and strengthening the connection, thereby achieving positioning between each screen 3, so that the screen 3 can remain stable during the cleaning process.

[0062] As a preferred embodiment, a cover plate 11 is provided on the top of the cleaning container 1, which can form a relatively sealed cleaning environment inside the cleaning container 1, which is conducive to ensuring the cleaning effect. A channel 12 for the stirring device 5 to pass through is provided on the cover plate 11, and an emptying valve 13 is provided at the bottom of the cleaning container 1, which is conducive to draining the waste liquid in the cleaning container 1. The structure is simple and reliable.

[0063] Although the present invention has been disclosed as above with preferred embodiments, it is not intended to limit the present invention. Any technician familiar with the art can make many possible changes and modifications to the technical solution of the present invention by using the technical content disclosed above without departing from the scope of the technical solution of the present invention, or modify it into an equivalent embodiment of equivalent changes. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention should fall within the scope of protection of the technical solution of the present invention.

Claims

1. A chromatography screen cleaning method, characterized in that: The following steps are involved: Fixing the screen (3) on the screen positioning assembly (4) in the cleaning container (1); A cleaning agent for pickling is added to the cleaning container (1) to remove scale and rust on the surface of the screen (3). During the pickling process, the stirring device (5) above the screen positioning assembly (4) rotates to stir the cleaning liquid; The cleaning container (1) is drained to remove the waste liquid, and then purified water is added to the cleaning container (1) for flushing; A cleaning agent for salt washing is added to the cleaning container (1) to remove free impurities attached to the screen (3). During the salt washing process, the stirring device (5) rotates to stir the cleaning liquid; The cleaning container (1) is drained to remove the waste liquid, and then purified water is added to the cleaning container (1) for flushing; A cleaning agent for alkaline cleaning is added to the cleaning container (1) to remove fat-soluble substances attached to the screen (3). During the alkaline cleaning process, the stirring device (5) rotates to stir the cleaning liquid; The cleaning container (1) is drained to remove the waste liquid, and then purified water is added to the cleaning container (1) for flushing.

2. The chromatography screen cleaning method according to claim 1, characterized in that: The cleaning agent used for pickling is 1-2 mol / L acetic acid, and the cleaning time is 2-5 hours.

3. The chromatography screen cleaning method according to claim 2, characterized in that: The cleaning agent used for salt washing is 1-3 mol / L sodium chloride, and the cleaning time is 0.5-2 hours.

4. The chromatography screen cleaning method according to claim 3, characterized in that: The cleaning agent used for alkaline cleaning is 0.5 to 2 mol / L sodium hydroxide, and the cleaning time is 0.5 to 2 hours.

5. The chromatography screen cleaning method according to any one of claims 1 to 4, characterized in that: The rinsing time after acid washing is 3 to 20 minutes, the rinsing time after salt washing is 3 to 20 minutes, and the rinsing time after alkali washing is 5 to 25 minutes.

6. The chromatography screen cleaning method according to claim 5, characterized in that: After acid washing and salt washing, the conductivity value of the screen (3) is tested to be less than 10 μS / cm and the washing is stopped; After the alkaline washing, the conductivity value of the screen (3) is detected to be zero and then the washing is stopped.

7. The chromatography screen cleaning method according to any one of claims 1 to 4, characterized in that: The stirring device (5) is connected to a stirring driving member (51), the stirring driving member (51) is arranged on a mounting seat (21), the mounting seat (21) is arranged on a bracket (2), and the bracket (2) is provided with a lifting driving member (22) for driving the mounting seat (21) to rise and fall, and a lifting guide rail (23) for providing guidance for the mounting seat (21).

8. The chromatography screen cleaning method according to any one of claims 1 to 4, characterized in that: The screen positioning assembly (4) comprises a base (41), the base (41) is provided with at least one positioning screw (42), the outer periphery of the positioning screw (42) is provided with a plurality of positioning blocks (44) and the upper end is threadedly connected with a locking block (45), the positioning block (44) is provided with a first positioning portion (441) and a first flange (442) located above the first positioning portion (441), the locking block (45) is provided with a second positioning portion (451) and a second flange (442) located above the second positioning portion (451), The first positioning portion (441) and the second positioning portion (451) are provided with the screen (3) and the isolation pad (46) on their outer peripheries, the diameter of the isolation pad (46) is larger than the diameter of the first positioning portion (441) and the second positioning portion (451), the uppermost screen (3) is sandwiched between the second flange (452) and the adjacent isolation pad (46), and the remaining screens (3) are sandwiched between the first flange (442) and the isolation pad (46) below.

9. The chromatography screen cleaning method according to claim 8, characterized in that: The base (41) is provided with a plurality of adjustment blocks (43), and the adjustment blocks (43) are threadedly connected to the base (41); And / or, a concave-convex positioning structure is provided between two upper and lower adjacent positioning blocks (44), and a concave-convex positioning structure is also provided between the locking block (45) and the adjacent positioning block (44).

10. The chromatography screen cleaning method according to any one of claims 1 to 4, characterized in that: The top of the cleaning container (1) is provided with a cover plate (11), the cover plate (11) is provided with a channel (12) for the stirring device (5) to pass through, and the bottom of the cleaning container (1) is provided with an emptying valve (13).

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