Formula powder containing various amino acids and preparation method thereof

Abstract

The invention belongs to the technical field of nutritional agents, and discloses formula powder containing various amino acids and a preparation method of the formula powder. The formula powder comprises the following components in parts by weight: 20-30 parts of mixed carbohydrate, 10-16 parts of compound amino acid, 20-30 parts of mixed vegetable oil, 0.15-0.5 part of functional fatty acid, 1-5 parts of mineral substances, 2-10 parts of compound nutrients, 0.1-0.5 part of vitamins, 0.1-0.5 part of a functional additive, 0.1-0.5 part of a stabilizer and 0.1-0.5 part of an antioxidant. The compound amino acid is prepared from L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine and L-methionine, and the compound amino acid is prepared from L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine and L-methionine. The formula powder provided by the invention is comprehensive in nutrition, high in bioavailability and strong in stability through synergistic proportioning of the compound amino acid and precise addition of the functional fatty acid.

Description

Technical Field

[0001] The present invention relates to the technical field of nutrient preparations, and in particular to a formula powder containing multiple amino acids and a preparation method thereof. Background Art

[0002] Breast milk is the most ideal natural food for babies, but when breast milk is insufficient or unavailable, infant formula is a better substitute for breast milk.

[0003] Protein is an important material basis for early growth and development. The digestion and absorption of protein is of great significance to the growth and development of infants and various physiological functions. Amino acids are the basic building blocks of protein, and their balanced ratio and efficient absorption are the core of nutritional formula design. However, existing amino acid formula products still have many limitations: most products only contain essential amino acids, lack of scientific ratios of conditionally essential amino acids (such as glutamine, arginine, etc.) and non-essential amino acids, and it is difficult to meet the comprehensive needs of body repair, immune regulation, etc.; the degree to which amino acids are absorbed and utilized by the body will directly affect their nutritional value, and the digestion and absorption of amino acids is affected by the composition and interaction of multiple amino acids. Other ingredients such as fats, minerals and carbohydrates will affect their digestion and absorption characteristics; some formulas lack key functional ingredients (such as arachidonic acid ARA, docosahexaenoic acid DHA), or the synergistic supplementation of minerals and vitamins is insufficient, resulting in limited nutritional support effects; stability and absorption efficiency issues: the combination of carbohydrates and vegetable oils in traditional formulas may affect solubility, and high-temperature processing is prone to degradation of heat-sensitive ingredients (such as vitamins and antioxidants), reducing product efficacy.

[0004] Therefore, how to provide a solution suitable for the digestive system of infants and young children while improving the digestion and absorption of amino acids is a problem that needs to be solved urgently. Summary of the invention

[0005] The purpose of the present invention is to provide a formula powder containing multiple amino acids and a preparation method thereof, and to provide a formula powder with comprehensive nutrition and high amino acid absorption efficiency through the synergistic ratio of composite amino acids and the precise addition of other raw materials.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a formula powder containing multiple amino acids, comprising the following raw materials in parts by weight:

[0008] 20-30 parts of mixed carbohydrates, 10-16 parts of complex amino acids, 20-30 parts of mixed vegetable oils, 0.15-0.5 parts of functional fatty acids, 1-5 parts of minerals, 2-10 parts of complex nutrients, 0.1-0.5 parts of vitamins, 0.1-0.5 parts of functional additives, 0.1-0.5 parts of stabilizers and 0.1-0.5 parts of antioxidants;

[0009] The complex amino acids include L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-alanine, L-cystine, L-tryptophan, L-methionine, and L-citrulline.

[0010] Preferably, in the above-mentioned formula powder containing multiple amino acids, the composite amino acid comprises the following raw materials in parts by weight:

[0011] 7-12 parts of L-leucine, 5-10 parts of L-lysine acetate, 5-10 parts of L-glutamine, 4-8 parts of L-proline, 4-8 parts of L-arginine, 4-7 parts of L-valine, 3-6 parts of glycine, 4-7 parts of L-isoleucine, 3-6 parts of L-aspartic acid, 3-6 parts of L-threonine, 3-6 parts of L-phenylalanine, 2-5 parts of L-tyrosine, 3-6 parts of L-serine, 2-5 parts of L-histidine, 3-6 parts of L-alanine, 1-3 parts of L-cystine, 1-3 parts of L-tryptophan, 1-3 parts of L-methionine, and 3-5 parts of L-citrulline.

[0012] Preferably, in the above-mentioned formula powder containing multiple amino acids, the mixed carbohydrates include the following raw materials in parts by mass:

[0013] 20-30 parts of glucose syrup, 20-35 parts of maltodextrin, 10-15 parts of resistant dextrin, 5-7 parts of oligofructose, 5-10 parts of waxy corn starch, 5-10 parts of 2'-fucosyllactose;

[0014] The mixed vegetable oil comprises the following raw materials in parts by weight:

[0015] 40-60 parts of sunflower oil, 20-40 parts of medium-chain triglycerides, 10-30 parts of rapeseed oil, 1-3 parts of algae oil DHA, and 2-5 parts of linseed oil.

[0016] Preferably, in the above-mentioned formula powder containing multiple amino acids, the functional fatty acids include arachidonic acid oil, docosahexaenoic acid oil, inositol and eicosapentaenoic acid;

[0017] The mass ratio of arachidonic acid oil, docosahexaenoic acid oil inositol and eicosapentaenoic acid is 1.5-2.5:1:1-2;

[0018] The minerals include the following raw materials in parts by weight:

[0019] 7-12 parts of magnesium citrate, 5-10 parts of calcium hydrogen phosphate, 5-10 parts of potassium citrate, 4-8 parts of calcium citrate, 3-6 parts of sodium chloride, 2-5 parts of magnesium chloride, 3-6 parts of ferrous glycinate, 1-3 parts of zinc sulfate, 4-8 parts of copper sulfate, 4-7 parts of manganese sulfate, 2-5 parts of potassium iodide, 1-3 parts of sodium selenite, 1-3 parts of sodium molybdate and 1-3 parts of chromium chloride.

[0020] Preferably, in the above-mentioned formula powder containing multiple amino acids, the composite nutrient comprises the following raw materials in parts by weight:

[0021] Lactoferrin 7-9 parts, zinc glycine chelate 2-3 parts, magnesium lysine chelate 2-3 parts, phosphatidylserine 9-11 parts;

[0022] The vitamins include the following raw materials in parts by weight:

[0023] 1-3 parts of L-ascorbic acid, 4-7 parts of D-biotin, 2-5 parts of D-calcium pantothenate, 1-3 parts of pyridoxine hydrochloride, 3-6 parts of thiamine hydrochloride, 4-7 parts of riboflavin, 7-12 parts of niacinamide, 2-5 parts of folic acid, 1-3 parts of cyanocobalamin, 1-3 parts of vitamin A acetate, 1-3 parts of dl-a-tocopherol acetate, 1-3 parts of dl-a-tocopherol, and 1-3 parts of phytonadione.

[0024] Preferably, in the above-mentioned formula powder containing multiple amino acids, the functional additives include the following raw materials in parts by weight:

[0025] 7-12 parts of nucleotides, 2-8 parts of L-carnitine, 2-8 parts of taurine;

[0026] The nucleotides include disodium 5-uridylate, adenosine 5'-monophosphate, cytidine 5'-monophosphate and disodium 5-inosinate;

[0027] The mass ratio of the 5-uridylic acid disodium, 5'-adenosine monophosphate, 5'-cytidine monophosphate and 5-inosinic acid disodium is 1-3:1-3:1-3:1-3.

[0028] Preferably, in the above-mentioned formula powder containing multiple amino acids, the stabilizer includes citric acid fatty acid glyceride;

[0029] The antioxidant includes ascorbyl palmitate.

[0030] The present invention also provides a method for preparing a formula powder containing multiple amino acids, comprising the following steps:

[0031] Mixing the mixed carbohydrates, the complex amino acids, the mixed vegetable oils and the functional fatty acids to obtain a first mixture;

[0032] preparing a mineral mixture, and mixing the mineral mixture with the first mixture to obtain a second mixture;

[0033] preparing a vitamin mixture, mixing the vitamin mixture, complex nutrients, functional additives and the second mixture to obtain a third mixture;

[0034] The stabilizer, the antioxidant and the third mixture are mixed, and after the mixing is completed, the mixed product is spray-dried, and then cooled and sieved in sequence to obtain a formula powder containing multiple amino acids.

[0035] Preferably, in the above-mentioned method for preparing formula powder containing multiple amino acids, the inlet air temperature of the spray drying is 180-220°C, and the outlet air temperature of the spray drying is 80-100°C.

[0036] Preferably, in the above method for preparing formula powder containing multiple amino acids, the sieving screen has a mesh size of 60 to 100.

[0037] It can be seen from the above technical solution that compared with the prior art, the present invention has the following beneficial effects:

[0038] This formula powder contains mixed carbohydrates, complex amino acids, mixed vegetable oils, functional fatty acids, minerals, vitamins, functional additives and other ingredients. The ingredients cooperate with each other to provide comprehensive nutrition for the human body. The glucose syrup and maltodextrin in the mixed carbohydrates are matched in a specific ratio, which can provide energy quickly and continuously; the complex amino acids cover 18 essential and non-essential amino acids for the human body, and the proportion of each amino acid is scientific, such as L-leucine, L-lysine acetate, etc., which can meet the needs of human growth and development, metabolism, immune regulation and other aspects. The mixed vegetable oil provides rich unsaturated fatty acids and easy-to-digest medium-chain fatty acids, which are helpful for cardiovascular health and reduce the digestive burden. Functional fatty acids are essential for the development of the nervous system and vision. The comprehensive addition of minerals and vitamins ensures the normal progress of various enzymatic reactions, metabolism and physiological functions of the human body. At the same time, the complex nutrients can improve the absorption of amino acids in formula powder by infants and young children; this comprehensive and balanced nutritional formula can meet the human body's needs for a variety of nutrients and maintain the body's normal physiological functions.

[0039] For infants and young children, whose digestive systems are not yet fully developed, the easily digestible and absorbable ingredients in this formula powder, such as medium-chain triglycerides and a reasonable ratio of complex amino acids, help meet their special nutritional needs for growth and development and promote the healthy development of the brain and body. The functional additives in the formula further enhance the nutritional value and functionality of the product. Nucleotides play an important role in immune regulation and intestinal development, can enhance the body's immunity, promote the growth of beneficial intestinal bacteria, and improve the intestinal microecological environment. DETAILED DESCRIPTION

[0040] The present invention provides a formula powder containing multiple amino acids, comprising the following raw materials in parts by weight:

[0041] 20-30 parts of mixed carbohydrates, 10-16 parts of complex amino acids, 20-30 parts of mixed vegetable oils, 0.15-0.5 parts of functional fatty acids, 1-5 parts of minerals, 2-10 parts of complex nutrients, 0.1-0.5 parts of vitamins, 0.1-0.5 parts of functional additives, 0.1-0.5 parts of stabilizers and 0.1-0.5 parts of antioxidants. The formula includes mixed carbohydrates, complex amino acids, mixed vegetable oils, functional fatty acids, minerals, complex nutrients, vitamins, functional additives, stabilizers and antioxidants, providing comprehensive nutritional support for infants and young children to meet the needs of different physiological functions. Mixed carbohydrates provide energy, and complex amino acids are the basic units of protein, which are used for the repair and growth of body tissues.

[0042] In the present invention, the weight proportion of the mixed carbohydrates in the formula powder may be 20, 22, 23, 25, 26, 27, 28, 29 or 30 parts.

[0043] In the present invention, the weight proportion of the composite amino acid in the formula powder may be 10, 11, 12, 13, 14, 15 or 16 parts.

[0044] In the present invention, the weight proportion of the mixed vegetable oil in the formula powder may be 20, 22, 23, 25, 26, 27, 28, 29 or 30 parts.

[0045] In the present invention, the weight proportion of the functional fatty acid in the formula powder may be 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45 or 0.5.

[0046] In the present invention, the weight proportion of minerals in the formula powder may be 1, 2, 3, 4 or 5 parts.

[0047] In the present invention, the weight proportions of the composite nutrients in the formula powder may be 2, 3, 4, 5, 6, 7, 8, 9 or 10 parts.

[0048] In the present invention, the weight proportion of vitamins in the formula powder may be 0.1, 0.2, 0.3, 0.4 or 0.5.

[0049] In the present invention, the weight proportion of the functional additive in the formula powder may be 0.1, 0.2, 0.3, 0.4 or 0.5 parts.

[0050] In the present invention, the weight proportion of the stabilizer in the formula powder may be 0.1, 0.2, 0.3, 0.4 or 0.5 parts.

[0051] In the present invention, the weight proportion of the antioxidant in the formula powder may be 0.1, 0.2, 0.3, 0.4 or 0.5 parts.

[0052] In the present invention, the composite amino acids include L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-alanine, L-cystine, L-tryptophan, L-methionine, and L-citrulline. In the present invention, the formula powder contains 18 kinds of amino acids (such as L-leucine, L-lysine, L-glutamine, etc.), covering all the required essential amino acids and conditionally essential amino acids (such as glutamine and arginine), providing comprehensive protein synthesis raw materials, and promoting immune regulation and metabolic balance.

[0053] In the present invention, the composite amino acid comprises the following raw materials in parts by weight:

[0054] 7-12 parts of L-leucine, 5-10 parts of L-lysine acetate, 5-10 parts of L-glutamine, 4-8 parts of L-proline, 4-8 parts of L-arginine, 4-7 parts of L-valine, 3-6 parts of glycine, 4-7 parts of L-isoleucine, 3-6 parts of L-aspartic acid, 3-6 parts of L-threonine, 3-6 parts of L-phenylalanine, 2-5 parts of L-tyrosine, 3-6 parts of L-serine, 2-5 parts of L-histidine, 3-6 parts of L-alanine, 1-3 parts of L-cystine, 1-3 parts of L-tryptophan, 1-3 parts of L-methionine, and 3-5 parts of L-citrulline. By limiting the specific proportion of each amino acid, the amino acid demand pattern is simulated, the metabolic burden is reduced, and the bioavailability is improved. It is especially suitable for infants and young children with weak digestion and absorption functions. That is, the above-mentioned precise matching of amino acids helps to improve the absorption efficiency of amino acids, better meet the needs of the human body to synthesize proteins and other nitrogen-containing compounds, and promote normal metabolism and growth and development of the body.

[0055] In the present invention, the mixed carbohydrates include the following raw materials in parts by weight:

[0056] 20-30 parts of glucose syrup, 20-35 parts of maltodextrin, 10-15 parts of resistant dextrin, 5-7 parts of oligofructose, 5-10 parts of waxy corn starch, and 5-10 parts of 2'-fucosyllactose. Glucose syrup and maltodextrin can quickly provide energy; resistant dextrin can increase satiety and promote intestinal peristalsis; oligofructose, as a prebiotic, helps regulate intestinal flora; waxy corn starch provides a continuous energy supply; 2'-fucosyllactose is beneficial to the intestinal health and immune regulation of infants and young children, and can also improve the absorption of amino acids by infants and young children and adapt to the digestive system of infants and young children.

[0057] In the present invention, the mixed vegetable oil comprises the following raw materials in parts by weight:

[0058] 40-60 parts of sunflower oil, 20-40 parts of medium-chain triglycerides, 10-30 parts of rapeseed oil, 1-3 parts of algae oil DHA, and 2-5 parts of linseed oil.

[0059] Mixed carbohydrates provide fast and slow-release energy to avoid drastic fluctuations in blood sugar; mixed vegetable oils provide balanced ω-3 / ω-6 fatty acids and medium-chain fatty acids, with high energy density and easy absorption. The specific proportion of vegetable oil combination can improve the emulsification and dispersibility of formula powder and reduce stratification or agglomeration.

[0060] In the present invention, the functional fatty acids include arachidonic acid oil, docosahexaenoic acid oil, inositol and eicosapentaenoic acid;

[0061] The mass ratio of arachidonic acid oil, docosahexaenoic acid oil inositol and eicosapentaenoic acid is 1.5-2.5:1:1-2. Fatty acids play an important role in the development of the human nervous system, immune regulation, cardiovascular health maintenance, etc. The appropriate ratio can make them work together to better play their role.

[0062] In the present invention, the minerals include the following raw materials in parts by weight:

[0063] 7-12 parts of magnesium citrate, 5-10 parts of calcium hydrogen phosphate, 5-10 parts of potassium citrate, 4-8 parts of calcium citrate, 3-6 parts of sodium chloride, 2-5 parts of magnesium chloride, 3-6 parts of ferrous glycinate, 1-3 parts of zinc sulfate, 4-8 parts of copper sulfate, 4-7 parts of manganese sulfate, 2-5 parts of potassium iodide, 1-3 parts of sodium selenite, 1-3 parts of sodium molybdate and 1-3 parts of chromium chloride.

[0064] In the present invention, the composite nutrient comprises the following raw materials in parts by weight:

[0065] 7-9 parts of lactoferrin, 2-3 parts of zinc glycine chelate, 2-3 parts of magnesium lysine chelate, and 9-11 parts of phosphatidylserine. The addition of complex nutrients can improve the absorption of amino acids in formula powder by infants and young children. Specifically: lactoferrin can inhibit the growth of harmful bacteria in the intestines, while promoting the proliferation of beneficial bacteria such as bifidobacteria; it helps to maintain the balance of intestinal microecology, create a healthy intestinal environment, and provide a good foundation for the absorption of amino acids; zinc glycine chelate and magnesium lysine chelate provide necessary elements to maintain the normal activity of enzymes, enhance the activity of digestive enzymes, and provide sufficient energy for the active transport of amino acids; regulate the activity of ion channels and transport proteins on the cell membrane, promote the entry of amino acids into cells through the cell membrane, and thus improve the absorption efficiency of amino acids.

[0066] In the present invention, the vitamins include the following raw materials in parts by weight:

[0067] 1-3 parts of L-ascorbic acid, 4-7 parts of D-biotin, 2-5 parts of D-calcium pantothenate, 1-3 parts of pyridoxine hydrochloride, 3-6 parts of thiamine hydrochloride, 4-7 parts of riboflavin, 7-12 parts of niacinamide, 2-5 parts of folic acid, 1-3 parts of cyanocobalamin, 1-3 parts of vitamin A acetate, 1-3 parts of dl-a-tocopherol acetate, 1-3 parts of dl-a-tocopherol, and 1-3 parts of phytonadione.

[0068] In the present invention, the functional additive comprises the following raw materials in parts by weight:

[0069] 7-12 parts of nucleotides, 2-8 parts of L-carnitine, and 2-8 parts of taurine.

[0070] In the present invention, the nucleotides include disodium 5-uridylate, adenosine 5'-monophosphate, cytidine 5'-monophosphate and disodium 5-inosinate;

[0071] The mass ratio of the 5-uridylic acid disodium, 5'-adenosine monophosphate, 5'-cytidine monophosphate and 5-inosinic acid disodium is 1-3:1-3:1-3:1-3.

[0072] In the present invention, the stabilizer includes citric acid fatty acid glyceride;

[0073] The antioxidant includes ascorbyl palmitate.

[0074] The present invention also provides a method for preparing a formula powder containing multiple amino acids, comprising the following steps:

[0075] Mixing the mixed carbohydrates, the complex amino acids, the mixed vegetable oils and the functional fatty acids to obtain a first mixture;

[0076] preparing a mineral mixture, and mixing the mineral mixture with the first mixture to obtain a second mixture;

[0077] preparing a vitamin mixture, mixing the vitamin mixture, complex nutrients, functional additives and the second mixture to obtain a third mixture;

[0078] The stabilizer, the antioxidant and the third mixture are mixed, and after the mixing is completed, the mixed product is spray-dried, and then cooled and sieved in sequence to obtain a formula powder containing multiple amino acids.

[0079] In the present invention, the air inlet temperature of the spray drying is 180-220°C, and the air outlet temperature of the spray drying is 80-100°C.

[0080] In the present invention, the sieve mesh is 60 to 100 meshes.

[0081] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0082] Example 1

[0083] A formula powder containing multiple amino acids, comprising the following raw materials in parts by weight:

[0084] 25 parts of mixed carbohydrates, 15 parts of complex amino acids, 20 parts of mixed vegetable oils, 0.45 parts of functional fatty acids, 3.5 parts of minerals, 5 parts of complex nutrients, 0.35 parts of vitamins, 0.2 parts of functional additives, 0.2 parts of stabilizer citric acid fatty acid glyceride and 0.4 parts of antioxidant ascorbyl palmitate.

[0085] The mixed carbohydrates include 20 parts of glucose syrup, 25 parts of maltodextrin, 13 parts of resistant dextrin, 8 parts of oligofructose, 10 parts of waxy corn starch, and 8 parts of 2'-fucosyllactose;

[0086] Complex amino acids, including 10 parts of L-leucine, 8 parts of L-lysine acetate, 7 parts of L-glutamine, 5 parts of L-proline, 7 parts of L-arginine, 5 parts of L-valine, 5 parts of glycine, 7 parts of L-isoleucine, 6 parts of L-aspartic acid, 5 parts of L-threonine, 4 parts of L-phenylalanine, 5 parts of L-tyrosine, 4 parts of L-serine, 3 parts of L-histidine, 3 parts of L-alanine, 2 parts of L-cystine, 2 parts of L-tryptophan, 2 parts of L-methionine, and 4 parts of L-citrulline;

[0087] Mixed vegetable oils, including 45 parts sunflower oil, 25 parts medium chain triglycerides, 20 parts rapeseed oil, 2 parts algae oil DHA, and 4 parts flaxseed oil;

[0088] The mass ratio of the functional fatty acids arachidonic acid oil, docosahexaenoic acid oil inositol and eicosapentaenoic acid is 1.5:1:1;

[0089] Minerals, including 10 parts of magnesium citrate, 8 parts of calcium hydrogen phosphate, 7 parts of potassium citrate, 7 parts of calcium citrate, 5 parts of sodium chloride, 4 parts of magnesium chloride, 5 parts of ferrous glycinate, 2 parts of zinc sulfate, 5 parts of copper sulfate, 5 parts of manganese sulfate, 4 parts of potassium iodide, 2 parts of sodium selenite, 2 parts of sodium molybdate and 2 parts of chromium chloride.

[0090] Complex nutrients, comprising the following raw materials in parts by weight:

[0091] Lactoferrin 8 parts, zinc glycine chelate 3 parts, magnesium lysine chelate 3 parts, phosphatidylserine 10 parts;

[0092] Vitamins, including 2 parts of L-ascorbic acid, 5 parts of D-biotin, 4 parts of D-calcium pantothenate, 2 parts of pyridoxine hydrochloride, 6 parts of thiamine hydrochloride, 7 parts of riboflavin, 10 parts of niacinamide, 3 parts of folic acid, 2 parts of cyanocobalamin, 2 parts of vitamin A acetate, 2 parts of dl-a-tocopherol acetate, 2 parts of dl-a-tocopherol, and 2 parts of phytonadione.

[0093] The functional additive comprises 10 parts of nucleotides, 6 parts of L-carnitine and 6 parts of taurine; the mass ratio of 5-uridylic acid disodium, 5'-adenosine monophosphate, 5'-cytidine monophosphate and 5-inosinic acid disodium in the nucleotides is 2:1:2:1.

[0094] The method for preparing a formula powder containing multiple amino acids comprises the following steps:

[0095] Mixing the mixed carbohydrates, the complex amino acids, the mixed vegetable oils and the functional fatty acids to obtain a first mixture;

[0096] Mixing minerals and water to obtain a mineral mixture, and mixing the mineral mixture with the first mixture to obtain a second mixture;

[0097] Mixing vitamins and water to obtain a vitamin mixture, and mixing the vitamin mixture, complex nutrients, functional additives and the second mixture to obtain a third mixture;

[0098] The stabilizer, antioxidant and the third mixture are mixed, and after the mixing is completed, the mixed product is spray-dried, the inlet air temperature of the spray drying is 180° C., the outlet air temperature of the spray drying is 80° C., and then cooled and passed through a 100-mesh sieve in sequence to obtain a formula powder containing multiple amino acids.

[0099] Example 2

[0100] A formula powder containing multiple amino acids, comprising the following raw materials in parts by weight:

[0101] 26 parts of mixed carbohydrates, 10 parts of complex amino acids, 30 parts of mixed vegetable oils, 0.4 parts of functional fatty acids, 3 parts of minerals, 5 parts of complex nutrients, 0.3 parts of vitamins, 0.2 parts of functional additives, 0.4 parts of stabilizer citric acid fatty acid glyceride and 0.5 parts of antioxidant ascorbyl palmitate.

[0102] The mixed carbohydrates include 25 parts of glucose syrup, 30 parts of maltodextrin, 13 parts of resistant dextrin, 6 parts of oligofructose, 8 parts of waxy corn starch, and 9 parts of 2'-fucosyllactose;

[0103] Complex amino acids, including 10 parts of L-leucine, 6 parts of L-lysine acetate, 10 parts of L-glutamine, 8 parts of L-proline, 8 parts of L-arginine, 6 parts of L-valine, 5 parts of glycine, 6 parts of L-isoleucine, 5 parts of L-aspartic acid, 4 parts of L-threonine, 4 parts of L-phenylalanine, 3 parts of L-tyrosine, 4 parts of L-serine, 3 parts of L-histidine, 4 parts of L-alanine, 2 parts of L-cystine, 2 parts of L-tryptophan, 2 parts of L-methionine, and 4 parts of L-citrulline;

[0104] Mixed vegetable oils, including 45 parts sunflower oil, 35 parts medium-chain triglycerides, 15 parts rapeseed oil, 3 parts algae oil DHA, and 4 parts flaxseed oil;

[0105] The mass ratio of the functional fatty acids arachidonic acid oil, docosahexaenoic acid oil inositol and eicosapentaenoic acid is 2:1:1;

[0106] Minerals, including 10 parts of magnesium citrate, 8 parts of calcium hydrogen phosphate, 8 parts of potassium citrate, 6 parts of calcium citrate, 5 parts of sodium chloride, 4 parts of magnesium chloride, 5 parts of ferrous glycinate, 2 parts of zinc sulfate, 5 parts of copper sulfate, 5 parts of manganese sulfate, 3 parts of potassium iodide, 2 parts of sodium selenite, 2 parts of sodium molybdate and 2 parts of chromium chloride.

[0107] Complex nutrients, comprising the following raw materials in parts by weight:

[0108] Lactoferrin 9 parts, zinc glycine chelate 3 parts, magnesium lysine chelate 3 parts, phosphatidylserine 11 parts;

[0109] Vitamins, including 2 parts of L-ascorbic acid, 5 parts of D-biotin, 3 parts of D-calcium pantothenate, 2 parts of pyridoxine hydrochloride, 4 parts of thiamine hydrochloride, 6 parts of riboflavin, 10 parts of niacinamide, 3 parts of folic acid, 2 parts of cyanocobalamin, 1 part of vitamin A acetate, 2 parts of dl-a-tocopherol acetate, 2 parts of dl-a-tocopherol, and 2 parts of phytonadione.

[0110] The functional additive comprises 10 parts of nucleotides, 8 parts of L-carnitine and 5 parts of taurine; the mass ratio of 5-uridylic acid disodium, 5'-adenosine monophosphate, 5'-cytidine monophosphate and 5-inosinic acid disodium in the nucleotides is 3:2:1:3.

[0111] The preparation method of the above formula powder containing multiple amino acids is the same as that in Example 1.

[0112] Example 3

[0113] A formula powder containing multiple amino acids, comprising the following raw materials in parts by weight:

[0114] 30 parts of mixed carbohydrates, 15 parts of complex amino acids, 25 parts of mixed vegetable oils, 0.4 parts of functional fatty acids, 4 parts of minerals, 3 parts of complex nutrients, 0.3 parts of vitamins, 0.3 parts of functional additives, 0.4 parts of stabilizer citric acid fatty acid glyceride and 0.4 parts of antioxidant ascorbyl palmitate.

[0115] The mixed carbohydrates include 20 parts of glucose syrup, 30 parts of maltodextrin, 12 parts of resistant dextrin, 6 parts of oligofructose, 5 parts of waxy corn starch, and 6 parts of 2'-fucosyllactose;

[0116] Complex amino acids, including 10 parts of L-leucine, 8 parts of L-lysine acetate, 7 parts of L-glutamine, 7 parts of L-proline, 7 parts of L-arginine, 6 parts of L-valine, 5 parts of glycine, 5 parts of L-isoleucine, 5 parts of L-aspartic acid, 5 parts of L-threonine, 5 parts of L-phenylalanine, 4 parts of L-tyrosine, 5 parts of L-serine, 4 parts of L-histidine, 4 parts of L-alanine, 2 parts of L-cystine, 2 parts of L-tryptophan, 2 parts of L-methionine, 4 parts of L-citrulline;

[0117] Mixed vegetable oils, including 50 parts sunflower oil, 25 parts medium-chain triglycerides, 25 parts rapeseed oil, 1 part algae oil DHA, and 5 parts flaxseed oil;

[0118] The mass ratio of the functional fatty acids arachidonic acid oil, docosahexaenoic acid oil inositol and eicosapentaenoic acid is 2.5:1:1;

[0119] Minerals, including 7 parts of magnesium citrate, 8 parts of calcium hydrogen phosphate, 8 parts of potassium citrate, 7 parts of calcium citrate, 5 parts of sodium chloride, 4 parts of magnesium chloride, 5 parts of ferrous glycinate, 2 parts of zinc sulfate, 5 parts of copper sulfate, 5 parts of manganese sulfate, 4 parts of potassium iodide, 2 parts of sodium selenite, 2 parts of sodium molybdate and 2 parts of chromium chloride.

[0120] Complex nutrients, comprising the following raw materials in parts by weight:

[0121] Lactoferrin 8 parts, zinc glycine chelate 3 parts, magnesium lysine chelate 3 parts, phosphatidylserine 10 parts;

[0122] Vitamins, including 2 parts of L-ascorbic acid, 5 parts of D-biotin, 4 parts of D-calcium pantothenate, 2 parts of pyridoxine hydrochloride, 5 parts of thiamine hydrochloride, 5 parts of riboflavin, 8 parts of niacinamide, 5 parts of folic acid, 1 part of cyanocobalamin, 3 parts of vitamin A acetate, 2 parts of dl-a-tocopherol acetate, 2 parts of dl-a-tocopherol, and 2 parts of phytonadione.

[0123] The functional additive comprises 7 to 12 parts of nucleotides, 2 to 8 parts of L-carnitine and 2 to 8 parts of taurine; the mass ratio of 5-uridylic acid disodium, 5'-adenosine monophosphate, 5'-cytidine monophosphate and 5-inosinic acid disodium in the nucleotides is 1:1:1:1.

[0124] The preparation method of the above formula powder containing multiple amino acids is the same as that in Example 1.

[0125] Comparative Example 1

[0126] A formula powder containing multiple amino acids is consistent with Example 1, except that it does not contain complex nutrients.

[0127] Comparative Example 2

[0128] A formula powder containing multiple amino acids, which is consistent with Example 1, except that: the composite amino acid comprises 5 parts of L-leucine, 12 parts of L-lysine acetate, 12 parts of L-glutamine, 2 parts of L-proline, 10 parts of L-arginine, 3 parts of L-valine, 2 parts of glycine, 3 parts of L-isoleucine, 6 parts of L-aspartic acid, 5 parts of L-threonine, 4 parts of L-phenylalanine, 5 parts of L-tyrosine, 4 parts of L-serine, 3 parts of L-histidine, 3 parts of L-alanine, 2 parts of L-cystine, 2 parts of L-tryptophan, 2 parts of L-methionine, and 4 parts of L-citrulline

[0129] Comparative Example 3

[0130] A formula powder containing multiple amino acids, which is consistent with Example 1, except that: the composite amino acid comprises 10 parts of L-leucine, 8 parts of L-lysine acetate, 7 parts of L-glutamine, 5 parts of L-proline, 7 parts of L-arginine, 5 parts of L-valine, 5 parts of glycine, 7 parts of L-isoleucine, 2 parts of L-aspartic acid, 2 parts of L-threonine, 1 part of L-phenylalanine, 8 parts of L-tyrosine, 2 parts of L-serine, 1 part of L-histidine, 1 part of L-alanine, 5 parts of L-cystine, 5 parts of L-tryptophan, 4 parts of L-methionine, and 2 parts of L-citrulline

[0131] Comparative Example 4

[0132] A formula powder containing multiple amino acids is consistent with Example 1, except that: mixed carbohydrates include 20 parts of glucose syrup and 25 parts of maltodextrin.

[0133] Comparative Example 5

[0134] A formula powder containing multiple amino acids, which is consistent with Example 1, except that: the composite nutrient comprises the following raw materials in parts by weight:

[0135] 3 parts of zinc glycine chelate, 3 parts of magnesium lysine chelate, 10 parts of phosphatidylserine.

[0136] Performance Testing

[0137] 1. Solubility test

[0138] The solubility of the formula powder was tested in accordance with the relevant national standard GB 5413.29-2010 “National Food Safety Standard Determination of Solubility of Infant Food and Dairy Products”. The test results are shown in Table 1.

[0139] 2. Amino acid absorption efficiency test

[0140] According to the physiological parameters of the infant digestive system, an in vitro simulated digestion model was constructed to simulate the digestive environment of the mouth, stomach, small intestine, etc. The formula powder to be tested was made into a solution of a certain concentration and added into the simulated digestive system. Digestion was carried out according to the set time sequence and conditions. After digestion, the digestion products were separated by filtration and the composition and content of amino acids in the digestive fluid were determined by an amino acid analyzer, and then the absorption efficiency of amino acids was obtained. The test results are shown in Table 1.

[0141] 3. Allergenicity evaluation

[0142] BALB / c mouse sensitization model: intraperitoneal injection of formula powder + aluminum hydroxide once a week for 3 weeks; oral or intraperitoneal injection of formula powder in the 4th week; observation of allergic reactions: serum IgE level, spleen cell Th2 cytokine IL-4 secretion;

[0143] Blank test: multiple groups of BALB / c mice were intraperitoneally injected with saline + aluminum hydroxide once a week for 3 weeks; in the 4th week, the formula powder was gavaged or intraperitoneally injected; allergic reactions were observed: serum IgE level, spleen cell Th2 cytokine IL-4 secretion. The serum IgE level was 10-15 kU / L, and the spleen cell Th2 cytokine IL-4 secretion was 300-500 pg / mL.

[0144] Table 1 Performance test results of formula powder in embodiments and comparative examples

[0145]

[0146] As shown in Table 1, the solubility and amino acid absorption rate of the formula powder prepared in the embodiment are higher than those of the comparative example, and the absorption rate of amino acids in the formula powder prepared in the embodiment can be as high as 90% or more, indicating that the synergistic effect of the raw materials of the formula of the present invention is conducive to improving the absorption rate of amino acids in the formula powder. Example 1 contains composite nutrients, and its amino acid absorption efficiency is 92.9%. Comparative Example 1 does not contain composite nutrients, and the amino acid absorption efficiency is reduced to 80.5%; Comparative Example 5 lacks lactoferrin, and the amino acid absorption efficiency is 83.2%. It can be seen that the presence of composite nutrients, especially lactoferrin, has a significant effect on improving the solubility and amino acid absorption efficiency of the formula powder. Comparative Examples 2 and 3 change the ratio of each component in the composite amino acid, and the amino acid absorption efficiency is reduced to 81.2% and 79.3%, respectively. This shows that the specific ratio of each amino acid in the composite amino acid is critical to the solubility and amino acid absorption efficiency of the formula powder, and the change in ratio will affect the product performance. Comparative Example 4 contains only glucose syrup and maltodextrin, and the ingredients are greatly reduced, the solubility is reduced to 93.8%, and the amino acid absorption efficiency is reduced to 75.1%. This indicates that the combined effect of various ingredients of mixed carbohydrates is crucial to maintaining good solubility and amino acid absorption efficiency of the formula powder. In addition, the formula powders in the embodiments and comparative examples do not cause allergic reactions.

[0147] It can be seen that the selection and proportion of the ingredients in the formula powder in the embodiment are relatively reasonable, so that the product performs well in terms of solubility and amino acid absorption efficiency. The absence of any key ingredient or the change in the ingredient ratio may have a negative impact on the performance of the formula powder.

[0148] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A formula powder containing multiple amino acids, characterized in that: Contains the following raw materials in parts by weight: 20-30 parts of mixed carbohydrates, 10-16 parts of complex amino acids, 20-30 parts of mixed vegetable oils, 0.15-0.5 parts of functional fatty acids, 1-5 parts of minerals, 2-10 parts of complex nutrients, 0.1-0.5 parts of vitamins, 0.1-0.5 parts of functional additives, 0.1-0.5 parts of stabilizers and 0.1-0.5 parts of antioxidants; The complex amino acids include L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-alanine, L-cystine, L-tryptophan, L-methionine, and L-citrulline.

2. The formula powder containing multiple amino acids according to claim 1, characterized in that: The composite amino acid comprises the following raw materials in parts by weight: 7-12 parts of L-leucine, 5-10 parts of L-lysine acetate, 5-10 parts of L-glutamine, 4-8 parts of L-proline, 4-8 parts of L-arginine, 4-7 parts of L-valine, 3-6 parts of glycine, 4-7 parts of L-isoleucine, 3-6 parts of L-aspartic acid, 3-6 parts of L-threonine, 3-6 parts of L-phenylalanine, 2-5 parts of L-tyrosine, 3-6 parts of L-serine, 2-5 parts of L-histidine, 3-6 parts of L-alanine, 1-3 parts of L-cystine, 1-3 parts of L-tryptophan, 1-3 parts of L-methionine, and 3-5 parts of L-citrulline.

3. The formula powder containing multiple amino acids according to claim 1, characterized in that: The mixed carbohydrates include the following raw materials in parts by weight: 20-30 parts of glucose syrup, 20-35 parts of maltodextrin, 10-15 parts of resistant dextrin, 5-7 parts of oligofructose, 5-10 parts of waxy corn starch, 5-10 parts of 2'-fucosyllactose; The mixed vegetable oil comprises the following raw materials in parts by weight: 40-60 parts of sunflower oil, 20-40 parts of medium-chain triglycerides, 10-30 parts of rapeseed oil, 1-3 parts of algae oil DHA, and 2-5 parts of linseed oil.

4. The formula powder containing multiple amino acids according to claim 1, characterized in that: The functional fatty acids include arachidonic acid oil, docosahexaenoic acid oil, inositol and eicosapentaenoic acid; The mass ratio of arachidonic acid oil, docosahexaenoic acid oil inositol and eicosapentaenoic acid is 1.5-2.5:11-2; The minerals include the following raw materials in parts by weight: 7-12 parts of magnesium citrate, 5-10 parts of calcium hydrogen phosphate, 5-10 parts of potassium citrate, 4-8 parts of calcium citrate, 3-6 parts of sodium chloride, 2-5 parts of magnesium chloride, 3-6 parts of ferrous glycinate, 1-3 parts of zinc sulfate, 4-8 parts of copper sulfate, 4-7 parts of manganese sulfate, 2-5 parts of potassium iodide, 1-3 parts of sodium selenite, 1-3 parts of sodium molybdate and 1-3 parts of chromium chloride.

5. The formula powder containing multiple amino acids according to claim 1, characterized in that: The composite nutrient comprises the following raw materials in parts by weight: Lactoferrin 7-9 parts, zinc glycine chelate 2-3 parts, magnesium lysine chelate 2-3 parts, phosphatidylserine 9-11 parts; The vitamins include the following raw materials in parts by weight: 1-3 parts of L-ascorbic acid, 4-7 parts of D-biotin, 2-5 parts of D-calcium pantothenate, 1-3 parts of pyridoxine hydrochloride, 3-6 parts of thiamine hydrochloride, 4-7 parts of riboflavin, 7-12 parts of niacinamide, 2-5 parts of folic acid, 1-3 parts of cyanocobalamin, 1-3 parts of vitamin A acetate, 1-3 parts of dl-a-tocopherol acetate, 1-3 parts of dl-a-tocopherol, and 1-3 parts of phytonadione.

6. The formula powder containing multiple amino acids according to claim 1, characterized in that: The functional additive comprises the following raw materials in parts by weight: 7-12 parts of nucleotides, 2-8 parts of L-carnitine, 2-8 parts of taurine; The nucleotides include disodium 5-uridylate, adenosine 5'-monophosphate, cytidine 5'-monophosphate and disodium 5-inosinate; The mass ratio of the 5-uridylic acid disodium, 5'-adenosine monophosphate, 5'-cytidine monophosphate and 5-inosinic acid disodium is 1-3:1-3:1-3:1-3.

7. The formula powder containing multiple amino acids according to claim 1, characterized in that: The stabilizer includes citric acid fatty acid glyceride; The antioxidant includes ascorbyl palmitate.

8. The method for preparing a formula powder containing multiple amino acids according to any one of claims 1 to 7, characterized in that: The following steps are involved: Mixing the mixed carbohydrates, the complex amino acids, the mixed vegetable oils and the functional fatty acids to obtain a first mixture; preparing a mineral mixture, and mixing the mineral mixture with the first mixture to obtain a second mixture; preparing a vitamin mixture, mixing the vitamin mixture, complex nutrients, functional additives and the second mixture to obtain a third mixture; The stabilizer, the antioxidant and the third mixture are mixed, and after the mixing is completed, the mixed product is spray-dried, and then cooled and sieved in sequence to obtain a formula powder containing multiple amino acids.

9. The method for preparing a formula powder containing multiple amino acids according to claim 8, characterized in that: The inlet air temperature of the spray drying is 180-220°C, and the outlet air temperature of the spray drying is 80-100°C.

10. The method for preparing a formula powder containing multiple amino acids according to claim 9, characterized in that: The sieve mesh is 60 to 100 meshes.

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