Traditional Chinese medicine orally disintegrating tablet for freshening breath and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a traditional Chinese medicine orally disintegrating tablet for freshening breath and a preparation method thereof.The traditional Chinese medicine orally disintegrating tablet is prepared from, by weight, 10-45 parts of Chinese herbal medicine, 5-50 parts of disintegrating agent, 4-5 parts of flow aid, 140-210 parts of flavoring agent, 240-260 parts of filler and 8-12 parts of pigment, the weight ratio of the clove to the radix angelicae to the liquorice is (5-25): (2-6): (3-15). According to the orally disintegrating tablet disclosed by the invention, the proper filling agent and disintegrating agent are selected according to the variety screening of the prescription traditional Chinese medicines, so that the orally disintegrating tablet is good in dispersion effect and proper in tablet hardness, the bad taste can be successfully covered by screening the flavoring agent, the satisfactory taste of a user is obtained, and the effect of efficiently removing breath is favorably realized.

Description

Technical Field

[0001] The invention relates to the field of pharmaceutical preparations, and in particular to a Chinese medicine orodisintegrating tablet for refreshing breath and a preparation method thereof. Background Art

[0002] Bad breath is a common social annoyance that not only affects personal image, but may also indicate potential health problems. Most of the existing fresh breath products on the market mainly use fragrances to cover up bad breath, but the effect is not good, and there are problems such as inconvenient dosage forms and bad taste.

[0003] With the development of modern pharmaceutical technology, orally disintegrating tablets, as a new dosage form, have the advantages of rapid disintegration, easy to take, good taste, etc. Patent CN112076165B discloses an orally disintegrating tablet that can freshen breath, which is made of antibacterial essential oil, sulfur precipitant, filler, and adhesive as raw materials and is made by freeze drying process, wherein the antibacterial essential oil is composed of thymol, eucalyptus oil, methyl salicylate and peppermint oil. Patent CN106727268A discloses an orally disintegrating tablet and a preparation method thereof, which includes a disintegrant and a freshener, and the freshener includes Lactobacillus paracasei, Yunnan Baiyao extract and essence. However, it mainly achieves the effect of covering up the breath by adding essence or other chemical freshener components.

[0004] Natural Chinese medicine contains a large number of natural ingredients with antibacterial and anti-inflammatory effects, which can effectively inhibit bacterial growth, reduce the number of bacteria, and reduce the production of odor-causing substances VSCs (volatile sulfur compounds, mainly hydrogen sulfide, methyl mercaptan, and dimethyl sulfide); at the same time, the ingredients contained in Chinese medicine can combine with VSCs, reduce the production of VSCs, and effectively treat bad breath. Chinese medicine also contains a large number of natural fragrances, which have a fragrant and pleasant smell and cover up the odor produced by VSCs. The present invention uses natural Chinese medicine as a component for fresh breath, and develops a fresh breath orodisintegrating tablet that is easy to take, has a good taste, and uses natural Chinese medicine as the core of the product. Summary of the invention

[0005] In order to overcome the shortcomings of existing orodisintegrating breath freshening care products, the present invention provides a Chinese medicine orodisintegrating breath freshening tablet and a preparation method thereof.

[0006] The Chinese medicine orally disintegrating tablet of the present invention has the advantages of being easy to take, quickly disintegrating, having good compliance among people, and having good taste-masking effect, and improves the effect and stability of the product in removing bad breath.

[0007] The present invention is achieved through the following technical solutions:

[0008] A Chinese herbal orodisintegrating tablet for refreshing breath comprises the following raw material components in parts by weight: 10-45 parts of Chinese herbal medicine, 5-50 parts of disintegrant, 4-5 parts of glidant, 140-210 parts of flavoring agent, 240-260 parts of filler and 8-12 parts of pigment, wherein the Chinese herbal medicine comprises three components of clove, angelica dahurica and liquorice, and the weight ratio of the clove, angelica dahurica and liquorice is 5-25:2-6:3-15.

[0009] As a preferred technical solution, the Chinese medicine orally disintegrating tablet includes the following raw material components in parts by weight: 10-44 parts of Chinese herbal medicine, 6-50 parts of disintegrant, 4-5 parts of glidant, 140-210 parts of flavoring agent, 250 parts of filler, and 8-12 parts of pigment, wherein the Chinese herbal medicine includes three components: clove, angelica dahurica and licorice, and the weight ratio of the clove, angelica dahurica and licorice is 5-23:2-6:3-15. Further preferably, the weight ratio of clove, angelica dahurica and licorice is 3-5:1-2:2-4.

[0010] In a preferred embodiment, the percentage of the Chinese herbal medicine in the total weight of the orally disintegrating tablet is 2%-30%, preferably 2%-10%, and more preferably 2%-5.5%.

[0011] As a preferred technical solution, the disintegrant includes one or more of dry starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinyl pyrrolidone, preferably cross-linked sodium carboxymethyl cellulose, for example, in a certain embodiment, commercially available A Cross-linked carboxymethyl cellulose sodium.

[0012] In a preferred embodiment, the percentage of the disintegrant in the total weight of the orodisintegrating tablet is 0.5%-15%, preferably 1.0%-9%, and more preferably 1.3%-9%. This ratio helps to quickly disintegrate in the oral cavity. Experimental verification shows that the disintegration time can be controlled within 60 seconds.

[0013] As a preferred technical solution, the glidant includes one or more of magnesium stearate, micro-powder silica gel, magnesium silicate, and polyethylene glycol, and magnesium stearate is preferred.

[0014] In a preferred embodiment, the percentage of the glidant in the total weight of the orally disintegrating tablet is 0.5%-2.5%; preferably 0.7%-1.2.

[0015] As a preferred technical solution, the flavoring agent includes one or more of mannitol, xylitol, and lactose.

[0016] Further preferably, the flavoring agent comprises a mixture of mannitol, xylitol and lactose, and the weight ratio of mannitol, xylitol and lactose is 50-100:40-80:40-80.

[0017] Preferably, the mannitol is selected from commercially available 200SD;

[0018] Preferably, the lactose is selected from commercially available Anhydrous Lactose.

[0019] In a preferred embodiment, the flavoring agent accounts for 30%-40% of the total weight of the orodisintegrating tablet; preferably 32%-40%.

[0020] As a preferred technical solution, the filler includes one or more of sorbitol, microcrystalline cellulose, mannitol, and starch, preferably a commercially available brand 500% mannitol cross-polymerization and Maishan co-processing product.

[0021] As a preferred technical solution, the percentage of the filler in the total weight of the orally disintegrating tablet is 44%-60%; preferably, 45%-58%.

[0022] As a preferred technical solution, the pigment includes one or more of lemon yellow, sunset red, and turmeric, and turmeric is preferred.

[0023] In a preferred embodiment, the percentage of the pigment in the total weight of the orally disintegrating tablet is 0.1%-15%; preferably 1.5%-2.5%; more preferably 1.7%-2.4%.

[0024] A method for preparing a breath-freshening Chinese medicine orally disintegrating tablet comprises the following steps:

[0025] (1) Crush the Chinese herbal medicine pieces of clove, angelica dahurica and liquorice into fine powder;

[0026] (2) The fine powder of the medicinal material is mixed evenly with a disintegrant, a glidant, a flavoring agent, a filler, and a pigment, and the mixture is granulated and then tableted or directly tableted to obtain an orally disintegrating tablet.

[0027] As a preferred technical solution, in step (1), the Chinese herbal medicine pieces of clove, angelica dahurica and licorice are crushed into fine powder, all of which pass through a No. 5 sieve, and the amount passing through a No. 6 sieve is not less than 95%.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] The orodisintegrating tablet dosage form provided by the present invention is very different from traditional chewing gum, lozenges, etc. Traditional chewing gum needs to be chewed, and lozenges need to be dissolved in the mouth, while orodisintegrating tablets can be quickly disintegrated when placed in the mouth, without chewing or long-term disintegration, providing users with a more convenient way to freshen their breath. Compared with spray-type breath freshening products, orodisintegrating tablets are mainly absorbed through the oral mucosa, while sprays are more often briefly retained on the oral surface. This makes the refreshing effect of orodisintegrating tablets more durable, because their active ingredients can directly enter the blood circulation through the mucosa or act on the odor source in the oral cavity. Since orodisintegrating tablets can be quickly disintegrated in the oral cavity, the breath freshening ingredients therein can be immediately released and take effect. Users can feel that their breath has become fresh within a short time after putting in the orodisintegrating tablet, which has obvious advantages over some lozenges or chewing gum that take a certain amount of time to take effect. Secondly, orodisintegrating tablets are small in size and light in packaging. Unlike chewing gum, which may be sticky and easily contaminated with other items during carrying, sprays are not limited by capacity and air transportation restrictions (sprays may have restrictions on pressure tanks). As mentioned above, due to the absorption characteristics through the oral mucosa, the breath freshening effect can last for a long time. After using orodisintegrating tablets once, the breath can be kept fresh for a long period of time, reducing the trouble of frequent use of other breath freshening products. In terms of taste diversity, orodisintegrating tablets can be made into a variety of flavors to meet the taste preferences of different consumers. For example, they can have mint flavors, fruit flavors, etc. Compared with traditional chewing gum and lozenges, there are more possibilities for flavor innovation.

[0030] Cloves have a strong aromatic smell. The volatile oils and natural aromatic substances they contain can leave a light fragrance in the mouth, which can inhibit the odor of odor-causing substances VSCs, effectively cover up the smell of bad breath, and make the breath fresh. In the Eastern Han Dynasty of ancient China, according to the "Han Gong Yi", when the Shang Shu Lang reported to the emperor, he had to hold chicken tongue incense in his mouth to keep his breath fresh and avoid leaving a bad impression on the emperor. During the Three Kingdoms period, Cao Cao mentioned in "Letter to Zhuge Liang" that "I now present five pounds of chicken tongue incense to show my slight intention", which shows that cloves were used as gifts at that time and had the effect of refreshing breath. Clove oil and eugenol in cloves have antibacterial and anti-inflammatory effects, which can inhibit the growth of bacteria in the mouth, reduce odor-causing substances VSCs, and reduce the odor produced by bacteria decomposing food residues, thereby improving breath. Secondly, cloves are warm in nature and can warm the middle and dispel cold. They have a certain effect on alleviating bad breath caused by stomach cold, stomach dysfunction, etc., and reduce bad breath caused by gastric qi reversal by regulating stomach function.

[0031] Angelica dahurica is warm in nature and pungent in taste. It belongs to the lung and stomach meridians. It has the effect of dispelling cold and dispelling cold. It can be used to treat bad breath caused by exogenous wind evil. It can reduce bad breath by dispelling wind evil. Angelica dahurica can dry out dampness and has a certain improvement effect on bad breath caused by phlegm-damp constitution. It can reduce the occurrence of bad breath by regulating the moisture in the body. In addition, Angelica dahurica has the effect of reducing swelling and pus discharge. It can be used to treat bad breath caused by oral inflammation such as swollen and painful gums and periodontitis. It can eliminate the root cause of bad breath by reducing inflammation.

[0032] Licorice has the function of harmonizing the medicinal properties, which can alleviate the irritation of cloves and angelica dahurica, making the compounded herbs more gentle and suitable for long-term use. It contains ingredients such as glycyrrhizic acid, which has anti-inflammatory effects and can reduce the odor caused by oral inflammation. It also has a certain detoxification effect and can be used to relieve bad breath caused by heat toxins in the body. On the other hand, licorice can replenish qi and tonify the middle, and has a certain improvement effect on bad breath caused by weak spleen and stomach. By regulating the spleen and stomach function, it promotes digestion and reduces the occurrence of bad breath.

[0033] The invention can improve the breath problem from multiple aspects by compounding three Chinese herbal medicines of clove, angelica dahurica and licorice in appropriate proportions, and has multiple functions such as freshening breath, inhibiting bacteria, regulating the spleen and stomach, and reducing inflammation.

[0034] In the preparation of qualified orodisintegrating tablets that meet the index requirements, the disintegrant, glidant and filler each play a vital role. The disintegrant ensures the rapid disintegration of the tablet in the oral cavity and the release of the drug, the glidant improves the fluidity and uniformity of the material during the production process, and the filler provides the necessary physical support and good taste. The reasonable selection and use of excipients jointly ensure the quality and performance of the orodisintegrating tablets of the present invention, and meet the clinical and patient use requirements. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 The disintegration time experimental data of the embodiments and comparative examples;

[0036] Figure 2 The tensile strength test data of the embodiments and comparative examples;

[0037] Figure 3 The following are the experimental data for scoring the fragrance retention effects of the embodiments and comparative examples. DETAILED DESCRIPTION

[0038] The above contents of the present invention are further described in detail below through embodiments, but this should not be understood as the scope of the above subject matter of the present invention being limited to the following examples, and all technologies realized based on the above contents of the present invention belong to the scope of the present invention.

[0039] Examples 1 to 6

[0040] Prepare the raw materials according to the formula in Table 1, and prepare orodisintegrating tablets according to the following preparation method: grind clove, angelica dahurica, and licorice into fine powder, pass through a No. 6 sieve, and set aside; weigh the fine powder of each medicinal material and auxiliary materials according to the prescription amount, mix them evenly, add magnesium stearate and mix evenly, and directly press into tablets after granulation.

[0041] Table 1 Raw material formula of Examples 1 to 6

[0042]

[0043]

[0044] Comparative Examples 1 to 8

[0045] Prepare the raw materials according to the formula in Table 2, and prepare orally disintegrating tablets according to the following preparation method: grind the medicinal materials into fine powder, pass through a No. 6 sieve, and set aside. Weigh the fine powder of each medicinal material and auxiliary materials according to the prescription amount, mix them evenly, add magnesium stearate and mix evenly, and directly press into tablets after granulation.

[0046] Table 2 Comparative Examples 1 to 8 Raw Material Formula

[0047]

[0048]

Performance test

[0049] The orally disintegrating tablets prepared in the examples and comparative examples were tested as follows.

[0050] 1. Drug sensory evaluation

[0051] Table 3 Drug sensory evaluation

[0052]

[0053] Specific implementation method:

[0054] (1) Taste

[0055] The compound is diluted to a concentration that cannot be perceived by the evaluator as the minimum threshold, and the average of the minimum thresholds obtained by all evaluators is used as the minimum threshold of the compound. Test whether the bitterness, sweetness, spiciness, etc. in the taste are appropriate or acceptable and whether there is strong irritation.

[0056] (2) The fragrance retention effect of orally disintegrating tablets

[0057] The sensory evaluation team evaluates the fragrance retention time and fragrance retention intensity, sets different time points (0.5 hours, 1 hour, 2 hours, etc.), and asks the evaluators to score the fragrance retention in the mouth according to the table below. The scoring criteria may include the intensity and pleasantness of the fragrance.

[0058] According to the sensory evaluation results, the fragrance retention intensity can still reach 8 points (out of 10 points) 1 hour after taking the orodisintegrating tablet, indicating that it has a good fragrance retention effect.

[0059] Table 4 Description of breath taste and freshness rating

[0060]

[0061]

[0062] The following is the specific test process of the fragrance effect:

[0063] a) Preparation

[0064] i. Sample preparation: Select a sufficient number of orally disintegrating tablet samples to ensure that each evaluator can perform the test at different time points. The samples should be numbered and marked so that the results can be recorded accurately.

[0065] ii. Selection and training of evaluators: Select evaluators with normal sense of smell and taste to form a sensory evaluation team. Train the evaluators to make them familiar with the description of lingering aroma and taste and the scoring level (the contents in Table 3) to ensure the consistency of the scoring standards.

[0066] b) Testing phase

[0067] i. Initial test (0 hours): Before taking the orodisintegrating tablet, the evaluator first self-evaluates the fragrance retention in his or her mouth and scores according to the scoring criteria in Table 3 as the initial data record.

[0068] ii. Set time point test:

[0069] 0.5 hour test After taking the orodisintegrating tablet, the evaluator waited for 0.5 hours. At this time point, the evaluator rated the aroma retention in the mouth according to factors such as the intensity and pleasure of the aroma, based on the rating scale in Table 3.

[0070] 1-hour test: One hour after taking the orodisintegrating tablet, the evaluator evaluates the intensity and pleasantness of the fragrance in the mouth and gives a score according to the rating scale. It is known that at this time point, the fragrance intensity can still reach 8 points (out of 10 points).

[0071] 2-hour test: 2 hours after taking the product, the evaluator will evaluate the lingering flavor in the mouth again and give a corresponding rating based on the description of the lingering flavor.

[0072] c) Results statistics and analysis stage

[0073] i. Data collection: Collect and summarize the scoring data of each evaluator at each time point.

[0074] ii. Data analysis: Calculate the average score at each time point and observe the trend of the fragrance retention effect over time. By analyzing the data, determine the fragrance retention strength and fragrance retention stability of the orodisintegrating tablet at different time points, so as to judge whether it has a good fragrance retention effect.

[0075] (3) Visual aspects

[0076] Whether the color is appetizing: Select a certain number of representative consumers or trained evaluators. Place the sheet sample on a white background and observe it under normal indoor light (for example, the light intensity is 500-1000 lux). The evaluators will score from "very appetizing (5 points)" to "completely unappetizing (1 point)" based on their subjective feelings after seeing the color.

[0077] Whether the color is uniform: These evaluators also observe and judge whether the color of the sample surface is consistent. If there is no obvious difference in color, it is recorded as "uniform". If there is obvious color difference or color spots, it is recorded as "uneven".

[0078] Whether the shape is a regular disc: The evaluator uses a measuring tool such as a caliper to measure the diameter of the sample (assuming it is a disc shape) and observes whether the edge is smooth. If the diameter deviation is within the allowable range (for example, ±0.5mm) and the edge is smooth, it is considered a regular disc, otherwise it is considered irregular.

[0079] Is the size easy to disintegrate in the mouth: Here, you can refer to the standard size range of relevant products. If the size of the sample is within this range, it is considered easy to disintegrate in the mouth. For example, for a certain lozenge, the standard size is 8-10mm in diameter and 2-3mm in thickness. If the sample meets this size, it is recorded as "yes", and if it does not meet this size, it is recorded as "no".

[0080] Whether the texture has pockmarks: the evaluator judges by touch and visual observation. If there are obvious small bumps or roughness on the surface, it is considered to have pockmarks, otherwise it is considered to have no pockmarks.

[0081] (4) Sense of smell

[0082] Is it irritating? Place the sample in a small, odorless sealed container. After opening the container, the evaluator sniffs it about 5 cm from the container mouth. If there is a pungent, tearful or other uncomfortable reaction, it is recorded as "irritating", otherwise it is recorded as "non-irritating".

[0083] Whether there is a special smell: During the sniffing process, the evaluator determines whether there is any other smell besides the smell that the product itself should have. If there is, the type of smell is recorded in detail (such as burnt smell, moldy smell, etc.); if there is no special smell, it is recorded as "no special smell".

[0084] 2. Disintegration time (DT) of orally disintegrating tablets

[0085] Disintegration time: The solid preparation is tested in a specified medium using a specified method to determine the time required for complete disintegration, dissolution into particles and passing through a sieve. The disintegration time of the test sample is determined according to Part 4 (0921 Disintegration Time Test Method) of the 2020 edition of the "Chinese Pharmacopoeia".

[0086] 3. Tensile Strength (TS) of Orally Disintegrating Tablets

[0087] After weighing and recording the mass of the tablets, use a vernier caliper to measure the thickness (H) and diameter (D) of the tablets, and use a hardness tester to measure the hardness (F) of the tablets. Calculate whether TS = 2F / πDH of each tablet can reach about 1.0.

[0088] 4. Tablet Fragility of Orally Disintegrating Tablets

[0089] According to the tablet friability test method (General Rule 0923) in Part IV of the Pharmacopoeia of the People's Republic of China (2020 Edition), take a number of tablets weighing 0.65g or less so that their total weight is about 6.5g; take 10 tablets if the tablet weight is greater than 0.65g. Use a hair dryer to blow away the powder that falls off the tablet, weigh it accurately, place it in a cylinder, and rotate it 100 times. Take it out, remove the powder in the same way, weigh it accurately, the weight loss shall not exceed 1%, and no broken, cracked or crushed tablets shall be detected. This test is generally performed only once. If the weight loss exceeds 1%, it should be repeated twice, and the average weight loss of 3 times shall not exceed 1%, and no broken, cracked or crushed tablets shall be detected.

[0090] The above experimental results are detailed in Table 5 and Figure 1 to Figure 3 .

[0091] Table 5 Test results

[0092]

[0093] Table 5 analyzes the effects of different types and contents of excipients and herbal medicine powder on tablet disintegration performance, tensile strength and sensory evaluation.

[0094] In terms of prescription optimization, after removing the Chinese medicinal material Chuanxiong, the remaining three medicinal materials still have the effect of removing bad breath, and the irritation and spicy smell are greatly reduced. Therefore, the drugs in the final formula are preferably cloves, angelica dahurica and licorice, with a weight ratio of 5-23:2-6:3-15.

[0095] Through sensory evaluation, a method of combining different flavoring agents was designed, the corresponding powders in the prescription amount were weighed and mixed evenly, and the best flavoring agent formula with suitable sweetness and cooling feeling, smooth surface, and high dissolution rate in the mouth was screened, which was a mixture of mannitol, xylitol, and lactose, and the weight ratio of mannitol, xylitol, and lactose was 50-100:40-80:40-80.

[0096] Through the visual aspect of sensory evaluation, in order to obtain a finished product with a uniform yellow appearance, the color-changing effects of lemon yellow, sunset red and turmeric on the tablets were compared. It can be found that when the pigment is turmeric, the color of the tablets is a more uniform light yellow, and 8 to 12 parts of the pigment are conducive to patient acceptance.

[0097] The function of the filler is to increase the weight and volume of the tablet, ensure that the tablet has a certain mechanical strength, and is easy to disintegrate in the oral cavity. The present invention selects mannitol cross-linked copolymerization and wheat syrup co-processing material 500 as a filler by designing a single factor experiment. The orally disintegrating tablet has a tensile strength of 1.0 kN / ㎡, completely disintegrates and passes through the sieve within 60 seconds, and has the weakest gravel feeling and a denser mouthfeel.

[0098] The main function of disintegrants is to quickly decompose the tablet structure when in contact with liquid, ensuring that the drug can be released in a short period of time. Commonly used disintegrants break the binding force of the tablet by absorbing water and swelling or forming a colloid, thereby achieving rapid disintegration. A Cross-linked sodium carboxymethyl cellulose is used as a disintegrant. Its specific mechanisms of action include water absorption and swelling, capillary action, wetting and penetration, which can control the disintegration time within 60 seconds.

[0099] The main function of the flow aid is to improve the fluidity of the powder and reduce the friction between particles, thereby ensuring that the material can evenly fill the mold during the tableting process, improving the continuity of production and the uniformity of the tablets. This product preferably uses magnesium stearate, which reduces the interaction force between particles by covering the surface of the particles, thereby improving the fluidity. In order to solve the sticking phenomenon that occurs during tableting, the effect of adding the lubricant-magnesium stearate is compared, and the corresponding powders in different prescriptions are weighed and mixed evenly. By increasing the content of magnesium stearate, the sticking phenomenon of the tablets is solved. Therefore, the content and type of lubricant in the final product are determined to be about 250 parts of magnesium stearate.

[0100] From the above experimental results, it can be seen that the orodisintegrating tablet dosage form provided by the present invention has key parameters such as tensile strength, tablet weight difference, disintegration time, friability, etc. that meet the quality requirements of orodisintegrating tablets, has the best palatability, and has a suitable appearance.

[0101] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. A Chinese medicine orodisintegrating tablet for refreshing breath, characterized in that: The invention comprises the following raw material components in parts by weight: 10 to 45 parts of Chinese herbal medicine, 5 to 50 parts of disintegrant, 4 to 5 parts of glidant, 140 to 210 parts of flavoring agent, 240 to 260 parts of filler, and 8 to 12 parts of pigment. The Chinese herbal medicine comprises three components: clove, angelica dahurica and licorice, and the weight ratio of the clove, angelica dahurica and licorice is 5-25:2-6:3-15.

2. The Chinese herbal orodisintegrating tablet for freshening breath according to claim 1, characterized in that: The invention comprises the following raw material components in parts by weight: 10 to 44 parts of Chinese herbal medicine, 6 to 50 parts of disintegrant, 4 to 5 parts of glidant, 140 to 210 parts of flavoring agent, 250 parts of filler, and 8 to 12 parts of pigment. The Chinese herbal medicine comprises three components: clove, angelica dahurica and licorice, and the weight ratio of the clove, angelica dahurica and licorice is 5-23:2-6:3-15.

3. A breath-freshening Chinese medicinal orodisintegrating tablet according to claim 1 or 2, characterized in that: The disintegrant includes one or more of dry starch, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinyl pyrrolidone, preferably cross-linked sodium carboxymethyl cellulose.

4. A breath-freshening Chinese medicinal orodisintegrating tablet according to claim 1 or 2, characterized in that: The glidant includes one or more of magnesium stearate, micro-powder silica gel, magnesium silicate, and polyethylene glycol, and magnesium stearate is preferred.

5. A breath-freshening Chinese medicinal orodisintegrating tablet according to claim 1 or 2, characterized in that: The flavoring agent includes one or more of mannitol, xylitol, and lactose.

6. The Chinese herbal orodisintegrating tablet for freshening breath according to claim 5, characterized in that: The flavoring agent includes a mixture of mannitol, xylitol, and lactose; The mannitol is selected from commercially available 200SD; The lactose is selected from commercially available Anhydrous Lactose.

7. A breath-freshening Chinese medicinal orodisintegrating tablet according to claim 1 or 2, characterized in that: The filler includes one or more of sorbitol, microcrystalline cellulose, mannitol, and starch, preferably a commercially available brand 500% mannitol cross-polymerization and Maishan co-processing product.

8. The Chinese herbal orodisintegrating tablet for freshening breath according to claim 1 or 2, characterized in that: The pigment includes one or more of lemon yellow, sunset red, and turmeric, and turmeric is preferably used.

9. The method for preparing a breath-freshening Chinese medicine orally disintegrating tablet according to claim 1 or 2, characterized in that: The following steps are involved: (1) Crush the Chinese herbal medicine pieces of clove, angelica dahurica and liquorice into fine powder; (2) The fine powder of the medicinal material is mixed evenly with a disintegrant, a glidant, a flavoring agent, a filler, and a pigment, and the mixture is granulated and then tableted or directly tableted to obtain an orally disintegrating tablet.

10. The method for preparing a breath-freshening Chinese medicine orally disintegrating tablet according to claim 9, characterized in that: Step (1) Crush the Chinese herbal medicine pieces of clove, angelica dahurica and liquorice into fine powder, all of which pass through a No. 5 sieve, and the amount passing through a No. 6 sieve is not less than 95%.

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