Pharmaceutical compositions comprising sting agonists and uses thereof

By combining STING endogenous agonists with magnesium salts or other stroke medications, the problem of neurological function repair after acute treatment of ischemic stroke has been solved, achieving gradual repair of brain function and a significant improvement in treatment efficacy.

CN119950718BActive Publication Date: 2026-06-19HANGZHOU XINGAO BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU XINGAO BIOTECH CO LTD
Filing Date
2023-11-09
Publication Date
2026-06-19

AI Technical Summary

⚠Technical Problem

Existing medications for ischemic stroke lack neurological function repair effects after acute treatment and have a narrow therapeutic window, making it difficult to effectively promote brain function recovery after emergency treatment.

⚗Method used

A pharmaceutical composition is formed by combining endogenous STING agonists such as 2',3'-cGAMP with magnesium salts or with drugs for treating stroke such as edaravone, for the treatment and repair of brain injury in ischemic stroke.

🎯Benefits of technology

It significantly prolongs the treatment window, improves cerebral blood circulation and neuroprotection, has significant brain function repair effects, and improves the treatment effect and survival rate of stroke.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention discloses pharmaceutical compositions containing endogenous STING agonists, and the use of these compositions in the preparation of medicaments for treating and / or repairing ischemic stroke brain injury; it also discloses the use of exogenous STING agonists, or compositions thereof with magnesium salts, or compositions thereof with stroke-treating pharmaceutical compositions in the preparation of medicaments for treating and / or repairing ischemic stroke brain injury. The pharmaceutical compositions containing STING agonists of this invention significantly improve efficacy in treating ischemic stroke and / or repairing brain injury, not only significantly alleviating the difficulty of a narrow emergency window, but also improving cerebral blood circulation and neuroprotection, and exhibiting significant brain function repair effects during subsequent rehabilitation.
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