Operating room anti-infection medical dressing and preparation method thereof

Abstract

The invention relates to the technical field of medical dressings, in particular to an anti-infection medical dressing for an operating room and a preparation method of the anti-infection medical dressing for the operating room. The dressing is prepared from the following components in parts by weight: 12 to 16 parts of herba cepbalanoplosis segeti, 8 to 16 parts of gallnut, 6 to 12 parts of silver nitrate, 4 to 10 parts of prodigiosin, 15 to 25 parts of N-hexyl alkylated chitosan and 4 to 6 parts of borneol. The copper alloy fiber net is laid on the micron-sized porous membrane, the first anti-infection dressing is laid on the copper alloy fiber net, the second anti-infection dressing is laid on the first anti-infection dressing, and the anti-infection medical dressing is obtained. The traditional Chinese medicine composition has the effects of sterilizing and inhibiting bacteria, resisting infection, stopping bleeding and diminishing inflammation, locally calming and promoting growth of granulation on a wound surface, and the purpose of repairing the wound surface is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of medical dressings, in particular to an anti-infection medical dressing for an operating room and a preparation method thereof. Background Art

[0002] In emergency situations, surgical treatment is required, and surgical treatment will inevitably cause bleeding from the wound. In the existing technology, natural fiber materials such as cotton, soft linen, and gauze are still the most widely used dressing materials in clinical practice. However, gauze is an inert dressing and has no obvious promoting effect on wound healing. When the dressing is soaked, pathogens can easily infect the wound; and the maintenance cost of the dressing is high, the workload of changing the dressing is large, and it cannot effectively prevent the invasion of bacteria. Antibiotic gauze, which is to add drug ingredients to the gauze when it is used, is also a common method for treating wounds, but it cannot solve the common problem of antibiotic resistance and cannot achieve the ideal anti-infection effect. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide an anti-infection medical dressing for an operating room to solve the above-mentioned problem.

[0004] In order to solve the above technical problems, the technical solution adopted by the present invention is: an anti-infection medical dressing for an operating room, comprising a micron-sized porous membrane, the upper surface of the micron-sized porous membrane containing a dressing, and the dressing comprising the following components in parts by weight: 12-16 parts of thistle, 8-16 parts of gallnut, 6-12 parts of silver nitrate, 4-10 parts of prodigiosin, 15-25 parts of N-hexyl chitosan, and 4-6 parts of borneol.

[0005] As a further solution of the present invention, the material of the micron-scale porous membrane substrate is a polymer containing hydroxyl groups.

[0006] As a further solution of the present invention, the micron-sized porous membrane substrate is a micron-sized porous fiber membrane substrate, and the material is one or more of cotton fiber, linen fiber, regenerated cellulose fiber, cellulose nanofiber, hyaluronic acid fiber or sodium alginate fiber.

[0007] As a further solution of the present invention, the pore size of the micron-sized porous membrane is 3-8 μm.

[0008] As a further solution of the present invention, the micron-sized porous membrane is connected to the dressing via a copper alloy fiber mesh woven from copper alloy fibers.

[0009] As a further embodiment of the present invention, the copper alloy fiber is a copper-magnesium alloy fiber or a copper-silver alloy fiber.

[0010] A method for preparing an anti-infection medical dressing for an operating room, the specific steps are as follows:

[0011] Step 1, weighing silver nitrate and prodigiosin by mass, adding them to an ethanol solution, stirring and adjusting the pH value to be neutral or weakly alkaline;

[0012] Step 2, adding the bacterial cellulose membrane into the mixed solution, reacting under high temperature and high pressure conditions, and then washing with pure water to obtain a first anti-infection dressing;

[0013] Step 3, weighing thistle, Chinese gallnut, and borneol by weight, and drying them to form powder;

[0014] Step 4, adding an appropriate amount of deionized water to the mixture of step 1, and adding N-hexyl chitosan, stirring and mashing into a paste to obtain a second anti-infection dressing;

[0015] Step 5: Lay the copper alloy fiber mesh on the micron-sized porous membrane, lay the first anti-infection dressing on the copper alloy fiber mesh, and lay the second anti-infection dressing on the first anti-infection dressing to obtain an anti-infection medical dressing.

[0016] As a further solution of the present invention, the high temperature in step 2 is 120-150° C., and the high pressure condition is 0.2-0.5 MPa.

[0017] As a further solution of the present invention, the copper alloy fiber mesh in step five is woven from copper alloy fibers, and the copper alloy fibers are copper-magnesium alloy fibers or copper-silver alloy fibers.

[0018] As a further solution of the present invention, the thickness of the anti-infection medical dressing is 0.8-1.2 cm

[0019] Since the present invention adopts the above technical solution, the present invention has the following advantages and positive effects:

[0020] 1. Thistle has a good killing and inhibiting effect on common hemolytic streptococci that are easy to infect wounds, while gallnut has a good killing and inhibiting effect on Staphylococcus aureus and some anaerobic bacteria that are easy to infect wounds. The two work together to kill and inhibit bacteria, resist infection, stop bleeding and reduce inflammation, calm the wound locally, and promote the growth of granulation tissue on the wound, thereby achieving the purpose of repairing the wound.

[0021] 2. The synergistic effect of silver nitrate and prodigiosin has better anti-infection properties against Escherichia coli and Staphylococcus aureus;

[0022] 3. The copper alloy fiber mesh woven by copper alloy fibers can release copper ions for a long time, which can effectively prevent and treat tissue infection around the material. The silver ions released by the decomposition of copper-silver alloy have the auxiliary performance of promoting wound healing. DETAILED DESCRIPTION

[0023] Example 1

[0024] The invention discloses an anti-infection medical dressing for an operating room, comprising a micron-sized porous membrane, wherein the upper surface of the micron-sized porous membrane contains a dressing, wherein the dressing comprises the following components in parts by weight: 12 parts of thistle, 8 parts of gallnut, 6 parts of silver nitrate, 4 parts of prodigiosin, 15 parts of N-hexylated chitosan, and 4 parts of borneol;

[0025] Among them, the material of the micron-sized porous membrane substrate is a polymer containing hydroxyl groups; the micron-sized porous membrane substrate is a micron-sized porous fiber membrane substrate, and the material is cotton fiber; the pore size of the micron-sized porous membrane is 3μm; the micron-sized porous membrane is connected to the dressing through a copper alloy fiber mesh woven from copper alloy fibers; the copper alloy fibers are copper-magnesium alloy fibers.

[0026] A method for preparing an anti-infection medical dressing for an operating room, the specific steps are as follows:

[0027] Step 1, weighing silver nitrate and prodigiosin by mass, adding them to an ethanol solution, stirring and adjusting the pH value to be neutral or weakly alkaline;

[0028] Step 2, adding the bacterial cellulose membrane into the mixed solution, reacting under the conditions of 120° C. and 0.2 MPa, and then washing with pure water to obtain the first anti-infection dressing;

[0029] Step 3, weighing thistle, Chinese gallnut, and borneol by weight, and drying them to form powder;

[0030] Step 4, adding an appropriate amount of deionized water to the mixture of step 1, and adding N-hexyl chitosan, stirring and mashing into a paste to obtain a second anti-infection dressing;

[0031] Step five, laying the copper alloy fiber mesh on the micron-sized porous membrane, laying the first anti-infection dressing on the copper alloy fiber mesh, and laying the second anti-infection dressing on the first anti-infection dressing to obtain an anti-infection medical dressing; in step five, the copper alloy fiber mesh is woven from copper alloy fibers, and the copper alloy fibers are copper-magnesium alloy fibers; the thickness of the anti-infection medical dressing is 0.8 cm.

[0032] Example 2

[0033] The invention discloses an anti-infection medical dressing for an operating room, comprising a micron-sized porous membrane, and is characterized in that: the upper surface of the micron-sized porous membrane contains a dressing, and the dressing comprises the following components in parts by weight: 13 parts of thistle, 11 parts of gallnut, 8 parts of silver nitrate, 6 parts of prodigiosin, 18 parts of N-hexylated chitosan, and 4 parts of borneol; the material of the micron-sized porous membrane substrate is a polymer containing hydroxyl groups; the micron-sized porous membrane substrate is a micron-sized porous fiber membrane substrate, and the material is hemp fiber and regenerated cellulose fiber; the pore size of the micron-sized porous membrane is 5 μm; the micron-sized porous membrane is connected to the dressing through a copper alloy fiber mesh woven from copper alloy fibers; the copper alloy fibers are copper-magnesium alloy fibers.

[0034] A method for preparing an anti-infection medical dressing for an operating room, the specific steps are as follows:

[0035] Step 1, weighing silver nitrate and prodigiosin by mass, adding them to an ethanol solution, stirring and adjusting the pH value to be neutral or weakly alkaline;

[0036] Step 2, adding the bacterial cellulose membrane into the mixed solution, reacting under the conditions of 130° C. and 0.3 MPa, and then washing with pure water to obtain the first anti-infection dressing;

[0037] Step 3, weighing thistle, Chinese gallnut, and borneol by weight, and drying them to form powder;

[0038] Step 4, adding an appropriate amount of deionized water to the mixture of step 1, and adding N-hexyl chitosan, stirring and mashing into a paste to obtain a second anti-infection dressing;

[0039] Step five, laying the copper alloy fiber mesh on the micron-sized porous membrane, laying the first anti-infection dressing on the copper alloy fiber mesh, and laying the second anti-infection dressing on the first anti-infection dressing to obtain an anti-infection medical dressing; in step five, the copper alloy fiber mesh is woven from copper alloy fibers, and the copper alloy fibers are copper-magnesium alloy fibers; the thickness of the anti-infection medical dressing is 0.9 cm.

[0040] Example 3

[0041] The invention discloses an anti-infection medical dressing for an operating room, comprising a micron-sized porous membrane, and is characterized in that: the upper surface of the micron-sized porous membrane contains a dressing, and the dressing comprises the following components in parts by weight: 15 parts of thistle, 12 parts of gallnut, 10 parts of silver nitrate, 8 parts of prodigiosin, 21 parts of N-hexylated chitosan, and 5 parts of borneol; the material of the micron-sized porous membrane substrate is a polymer containing hydroxyl groups; the micron-sized porous membrane substrate is a micron-sized porous fiber membrane substrate, and the material is regenerated cellulose fiber, cellulose nanofiber and hyaluronic acid fiber; the pore size of the micron-sized porous membrane is 6 μm; the micron-sized porous membrane is connected to the dressing through a copper alloy fiber mesh woven from copper alloy fibers; the copper alloy fibers are copper-silver alloy fibers.

[0042] A method for preparing an anti-infection medical dressing for an operating room, the specific steps are as follows:

[0043] Step 1, weighing silver nitrate and prodigiosin by mass, adding them to an ethanol solution, stirring and adjusting the pH value to be neutral or weakly alkaline;

[0044] Step 2, adding the bacterial cellulose membrane into the mixed solution, reacting under the conditions of 140° C. and 0.4 MPa, and then washing with pure water to obtain the first anti-infection dressing;

[0045] Step 3, weighing thistle, Chinese gallnut, and borneol by weight, and drying them to form powder;

[0046] Step 4, adding an appropriate amount of deionized water to the mixture of step 1, and adding N-hexyl chitosan, stirring and mashing into a paste to obtain a second anti-infection dressing;

[0047] Step five, laying the copper alloy fiber mesh on the micron-sized porous membrane, laying the first anti-infection dressing on the copper alloy fiber mesh, and laying the second anti-infection dressing on the first anti-infection dressing to obtain an anti-infection medical dressing; in step five, the copper alloy fiber mesh is woven from copper alloy fibers, and the copper alloy fibers are copper-silver alloy fibers; the thickness of the anti-infection medical dressing is 1 cm.

[0048] Example 4

[0049] The invention discloses an anti-infection medical dressing for an operating room, comprising a micron-sized porous membrane, wherein the upper surface of the micron-sized porous membrane contains a dressing, wherein the dressing comprises the following components in parts by weight: 16 parts of thistle, 16 parts of gallnut, 12 parts of silver nitrate, 10 parts of prodigiosin, 25 parts of N-hexylated chitosan, and 6 parts of borneol;

[0050] The material of the micron-sized porous membrane substrate is a polymer containing hydroxyl groups; the micron-sized porous membrane substrate is a micron-sized porous fiber membrane substrate, and the material is hyaluronic acid fiber and sodium alginate fiber; the pore size of the micron-sized porous membrane is 8 μm; the micron-sized porous membrane is connected to the dressing through a copper alloy fiber mesh woven from copper alloy fibers; the copper alloy fibers are copper-silver alloy fibers.

[0051] A method for preparing an anti-infection medical dressing for an operating room, the specific steps are as follows:

[0052] Step 1, weighing silver nitrate and prodigiosin by mass, adding them to an ethanol solution, stirring and adjusting the pH value to be neutral or weakly alkaline;

[0053] Step 2, adding the bacterial cellulose membrane into the mixed solution, reacting under the conditions of 150° C. and 0.5 MPa, and then washing with pure water to obtain a first anti-infection dressing;

[0054] Step 3, weighing thistle, Chinese gallnut, and borneol by weight, and drying them to form powder;

[0055] Step 4, adding an appropriate amount of deionized water to the mixture of step 1, and adding N-hexyl chitosan, stirring and mashing into a paste to obtain a second anti-infection dressing;

[0056] Step five, laying the copper alloy fiber mesh on the micron-sized porous membrane, laying the first anti-infection dressing on the copper alloy fiber mesh, and laying the second anti-infection dressing on the first anti-infection dressing to obtain an anti-infection medical dressing; in step five, the copper alloy fiber mesh is woven from copper alloy fibers, and the copper alloy fibers are copper-silver alloy fibers; the thickness of the anti-infection medical dressing is 1.2 cm.

[0057] The colony counts of the hemolytic group B Streptococcus, Escherichia coli, and Staphylococcus aureus groups were determined; the subscab tissues at the edge of the infected wound were taken for colony count determination on the 1st, 3rd, 7th, and 14th days after animal modeling. 100 mg of each subscab tissue was weighed, with a volume of about 0.5 cm 3 , grind in a glass homogenizer, then grind with physiological sodium chloride solution, dilute with physiological sodium chloride solution 10 times, take 100u1 of the liquid and apply it to the separation medium, incubate at 37℃ for 24h, select the target bacteria for bacterial count. -1 ) = (number of colonies x dilution factor x 100) / tissue weight (g).

[0058] Table 1 is the performance test of Examples 1-4

[0059]

[0060] As can be seen from Table 1, the present invention has a good killing and inhibitory effect on hemolytic streptococci, Escherichia coli, and Staphylococcus aureus, and can play the role of bacteriostasis, anti-infection, hemostasis and anti-inflammation, local sedation, and promotion of wound granulation growth, thereby achieving the purpose of repairing the wound.

[0061] Although specific embodiments of the present invention are described above, those skilled in the art should understand that these are merely examples and that various changes or modifications may be made to the embodiments without departing from the principles and essence of the present invention. The scope of protection of the present invention is limited only by the appended claims.

Claims

1. An anti-infection medical dressing for operating room, comprising a micron-sized porous membrane, characterized in that: The upper surface of the micron-sized porous membrane contains a dressing, which comprises the following components in parts by weight: 12-16 parts of thistle, 8-16 parts of gallnut, 6-12 parts of silver nitrate, 4-10 parts of prodigiosin, 15-25 parts of N-hexyl chitosan, and 4-6 parts of borneol.

2. The anti-infection medical dressing for operating room according to claim 1, characterized in that: The material of the micron-sized porous membrane substrate is a polymer containing hydroxyl groups.

3. The anti-infection medical dressing for operating room according to claim 2, characterized in that: The micron-sized porous membrane substrate is a micron-sized porous fiber membrane substrate, and the material is one or more of cotton fiber, hemp fiber, regenerated cellulose fiber, cellulose nanofiber, hyaluronic acid fiber or sodium alginate fiber.

4. The anti-infection medical dressing for operating room according to claim 1, characterized in that: The pore size of the micron-sized porous membrane is 3-8 μm.

5. The anti-infection medical dressing for operating room according to claim 1, characterized in that: The micron-sized porous membrane is connected to the dressing through a copper alloy fiber mesh woven from copper alloy fibers.

6. The anti-infection medical dressing for operating room according to claim 1, characterized in that: The copper alloy fiber is a copper-magnesium alloy fiber or a copper-silver alloy fiber.

7. A method for preparing an anti-infection medical dressing for an operating room according to any one of claims 1 to 6, characterized in that: Specific steps as follows: Step 1, weighing silver nitrate and prodigiosin by mass, adding them to an ethanol solution, stirring and adjusting the pH value to be neutral or weakly alkaline; Step 2, adding the bacterial cellulose membrane into the mixed solution, reacting under high temperature and high pressure conditions, and washing with pure water to obtain a first anti-infection dressing; Step 3, weighing thistle, Chinese gallnut, and borneol by weight, and drying them to form powder; Step 4, adding an appropriate amount of deionized water to the mixture of step 1, and adding N-hexyl chitosan, stirring and mashing into a paste to obtain a second anti-infection dressing; Step 5: Lay the copper alloy fiber mesh on the micron-sized porous membrane, lay the first anti-infection dressing on the copper alloy fiber mesh, and lay the second anti-infection dressing on the first anti-infection dressing to obtain an anti-infection medical dressing.

8. The method for preparing an anti-infection medical dressing for an operating room according to claim 7, characterized in that: In the step 2, the high temperature is 120-150° C., and the high pressure condition is 0.2-0.5 MPa.

9. The method for preparing an anti-infection medical dressing for an operating room according to claim 7, characterized in that: In the step 5, the copper alloy fiber mesh is woven from copper alloy fibers, and the copper alloy fibers are copper-magnesium alloy fibers or copper-silver alloy fibers.

10. The method for preparing an anti-infection medical dressing for an operating room according to claim 7, characterized in that: The thickness of the anti-infection medical dressing is 0.8-1.2 cm.

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