Ophthalmic medicine sterile delivery system capable of resisting pressure difference and preventing leakage

Abstract

The invention discloses an ophthalmology medicine pressure-difference-resistant leakage-proof sterile delivery system which comprises a drip nozzle, a valve body, a diaphragm valve and a sterilization filter element, a hollow spring column is arranged in an air collecting groove, the diaphragm valve is plugged on the air collecting groove, the drip nozzle is clamped on the valve body in a sealing mode, a distributor is arranged on the valve body in a sealing and sleeving mode, and the sterilization filter element is arranged on the valve body. A liquid dripping column with a liquid dripping hole is arranged on the dripping nozzle in an extending mode, a drainage column is arranged on the distributor in an extending mode, a plurality of drainage blocks are evenly distributed in the circumference of the drainage hole, the liquid dripping column abuts against the drainage blocks, a valve element coaxially aligned with a hollow spring column is arranged on the diaphragm valve, and the valve element abuts against the dripping nozzle to block the liquid dripping hole. The lower end of the valve element extends into the gas collecting groove, a pressure limiting deformation gap is reserved between the valve element and the hollow spring column, a reset spring is arranged between the valve element and the hollow spring column in a sleeved mode, the distributor is covered with a bottle cap, the bottle cap is provided with a conical plug, and the conical plug blocks the liquid dropping hole. The liquid medicine does not leak under the internal and external pressure difference environment.

Description

Technical Field

[0001] The invention relates to the field of medical packaging, in particular to an aseptic delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage. Background Art

[0002] In daily life, we need to use dropper bottles for precise drug delivery, and the most common one is eye dropper bottles. Currently, the dropper bottles on the market have the problem that the drug liquid is contaminated by air and flows back into the bottle after the dropper is completed, and the drug liquid remains on the dropper head.

[0003] In order to solve this problem, an air-blocking sterile drip bottle with an authorization announcement number of CN118415813B that can externally process residual liquid has appeared on the market. After the dripping is completed, the conical valve core on the diaphragm valve can seal the conical dripping hole in the drip nozzle under the action of the reset spring, and block the external air and residual liquid medicine outside. The outside air cannot enter the conical dripping hole and cause pollution to the conical dripping hole; and when the residual liquid medicine is refluxed, the drainage groove is directly connected to the outside air, thereby ensuring that the bottle body has good reset performance. In actual use, it was found that the dripping head in the sterile dripping bottle packaged in the plain area would leak in the plateau area and during air transportation. After analysis, it was found that after the sterile dripping bottle of this structure was packaged in the plain area, due to the sealing effect of the dripping head and the bottle body, the pressure in the bottle body was consistent with the external air pressure in the plain area. When the sterile dripping bottle entered the plateau area or was air transported, the external air pressure in the plateau area and high altitude became lower, and there was a pressure difference between the bottle body and the external environment - the pressure in the bottle body was greater than the air pressure of the external environment. When the dripping bottle was in a horizontal state, the medicine liquid in the bottle body entered the liquid inlet gap through the liquid inlet hole. When the medicine liquid in the bottle body was pushed by high pressure, it would push the diaphragm valve. After the diaphragm valve was pushed by the medicine liquid, it would move away from the drip nozzle. At this time, the conical valve core in the diaphragm valve was separated from the conical dripping hole in the dripping column to form a liquid outlet channel, and the arc-shaped protrusion on the bottle cap could not play a good sealing role, and the medicine liquid would leak out through the liquid outlet channel. In order to solve this problem, an air-blocking type sterile dripping bottle with authorization announcement number: CN118415813B, which can externally process residual liquid, is improved so that it no longer leaks due to pressure difference. Summary of the invention

[0004] The purpose of the present invention is to provide an aseptic delivery system for ophthalmic drugs that can resist pressure difference and prevent leakage without leakage of drug solution under internal and external pressure difference environment.

[0005] To achieve the above-mentioned purpose, the technical scheme adopted by the present invention is: a sterile delivery system for ophthalmic drugs that can resist pressure difference and prevent leakage, comprising: a drip nozzle, a valve body, a diaphragm valve and a hydrophobic sterilization filter element, a reflux groove, a return air hole, an air collecting groove, a liquid inlet hole and a plurality of interconnected isolation grooves are arranged on the valve body, a hollow spring column is arranged in the air collecting groove, a sterilization filter element is sealed on the valve body, the diaphragm valve is fixed on the valve body and sealed on the air collecting groove, a drip nozzle is sealed on the valve body, the drip nozzle is pressed on the diaphragm valve, a liquid inlet gap connected to the liquid inlet hole is formed between the drip nozzle, the diaphragm valve and the valve body, a distributor is sealed on the valve body, an annular gap connected to the reflux groove is formed between the distributor and the drip nozzle, a conical platform and a drip column are extended on the drip nozzle, an inverted cone-shaped drip hole is arranged in the drip column, and a A drainage column is provided, an inner conical hole is provided in the distributor, a drainage hole connected with the inner conical hole is provided in the drainage column, a plurality of drainage blocks are evenly distributed circumferentially in the drainage hole, a drainage groove connected with the annular gap is evenly distributed circumferentially on the inner side wall of the distributor, one end of the drainage groove transitions to the hole wall of the inner conical hole, the drip column extends into the drainage hole and abuts against the drainage block, the conical platform is located in the inner conical hole and does not fit with the inner conical hole, a valve core coaxially aligned with the hollow spring column is provided on the diaphragm valve, the upper end of the valve core abuts against the drip nozzle to block the drip hole, the lower end of the valve core extends into the air collecting groove, a pressure-limiting deformation gap is left between the valve core and the hollow spring column, a reset spring is mounted between the valve core and the hollow spring column, a bottle cap is covered on the distributor, a cone plug is provided on the bottle cap, the cone plug passes through the drainage hole and is inserted into the drip hole to block the drip hole.

[0006] Furthermore, the aforementioned aseptic delivery system for ophthalmic drugs is resistant to pressure difference and leakage, wherein a sealing hole connected to the drip hole is provided on the inner wall of the conical platform of the drip nozzle, the lower end of the drip column extends into the sealing hole, a sealing ring is protruding on the side wall of the sealing hole, the valve core rests on the lower end wall of the drip column, and the valve core is sealed and fitted with the sealing ring.

[0007] Furthermore, the aforementioned ophthalmic drug can resist pressure difference and prevent leakage aseptic delivery system, wherein the outer wall of the lower end of the drip column is an inclined wall, and a convex ring is extended upward at the upper end of the valve core, and the inner wall of the convex ring is in contact with the outer wall of the lower end of the drip column.

[0008] Furthermore, the aforementioned aseptic delivery system for ophthalmic drugs is resistant to pressure difference and leak-proof, wherein a weight-reducing hole is provided in the valve core.

[0009] Furthermore, the aforementioned aseptic delivery system for ophthalmic drugs is resistant to pressure difference and leakage, wherein a wedge-shaped hole adapted to the cone plug is provided on the large-diameter end of the drip hole.

[0010] Furthermore, in the aforementioned aseptic delivery system for ophthalmic drugs that is resistant to pressure difference and leak-proof, the top wall of the drainage block and the top wall of the drainage hole are both inclined downward from the outside to the inside, and a smooth transition is achieved between the two by a straight line connection.

[0011] The advantages of the present invention are as follows: when a sterile dropper bottle equipped with the sterile delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage of the present invention enters a low-pressure environment from a high-pressure environment, the cone plug on the bottle cap will always be blocked in the dropper hole, and even if the medicine in the bottle body pushes the diaphragm valve under the action of high pressure so that the valve core on the diaphragm valve no longer blocks the dropper hole, the medicine cannot leak out of the dropper hole after entering the dropper hole, thus achieving a good sealing effect; a pressure-limiting deformation gap is left between the valve core of the diaphragm valve and the hollow spring column, and no matter how much force is used to squeeze the bottle, the bottle cap will not be blocked. The bottle body can only be squeezed out of a fixed amount of liquid medicine, so that the liquid medicine can only drip out in the form of droplets, but not sprayed out in the form of a jet; a drainage block resting on the drip column is arranged in the drainage hole, which can diffuse the small droplets in the drip hole into large droplets, reduce the impact on the eyes during dripping, and reduce the discomfort of the user; a large gap is left between the drip nozzle and the dispenser, which can not only increase the reflux speed of the residual liquid medicine and the external air, but also increase the air flow between the isolation tank and the external environment, so that the residual liquid medicine in the isolation tank can evaporate faster. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a schematic structural diagram of a sterile delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage according to the present invention.

[0013] Figure 2 yes Figure 1 Schematic diagram of the structure of the middle drip nozzle.

[0014] Figure 3 yes Figure 1 Schematic diagram of the structure of the valve body.

[0015] Figure 4 yes Figure 1 Schematic diagram of the structure of the valve body in another direction.

[0016] Figure 5 Figure 4 Schematic diagram of the cross-sectional structure.

[0017] Figure 6 yes Figure 1 Schematic diagram of the structure of the diaphragm valve.

[0018] Figure 7 yes Figure 1 Schematic diagram of the structure of the distributor.

[0019] Figure 8 yes Figure 1 Schematic diagram of the structure of the middle bottle cap. DETAILED DESCRIPTION

[0020] The technical solution of the present invention is further described below in conjunction with the accompanying drawings and preferred embodiments.

[0021] like Figures 1 to 8 As shown, the sterile delivery system of ophthalmic drugs that can resist pressure difference and prevent leakage described in the present invention comprises: a dropper 1, a valve body 2, a diaphragm valve 3 and a hydrophobic sterilizing filter element 4, a reflux groove 21, a return air hole 22, a gas collecting groove 23, a liquid inlet 24 and a plurality of interconnected isolation grooves 25 are arranged on the valve body 2, a hollow spring column 231 is arranged in the gas collecting groove 23, and a sterilizing filter element 4 is sealed on the valve body 2. Regarding the position structure of the reflux groove 21, the return air hole 22, the gas collecting groove 23, the liquid inlet 24, and a plurality of isolation grooves 25 on the valve body 2 and the connection structure between the sterilizing filter element 4 and the valve body 2, reference can be made to the gas-blocking sterile dropper bottle that can externally process residual liquid with the authorization announcement number: CN118415813B.

[0022] The diaphragm valve 3 is fixed on the valve body 2 and blocks the air collecting groove 23. Regarding the connection structure between the diaphragm valve 3 and the valve body 2, reference may be made to the authorization announcement number: CN118415813B, which is a gas-blocking sterile dropper bottle that can perform external treatment of residual liquid. On this basis, the present invention makes the following improvements to the diaphragm valve 3: a valve core 31 coaxially aligned with the hollow spring column 231 is provided on the diaphragm valve 3, and a weight-reducing hole 311 is provided in the valve core 31 to reduce the weight of the diaphragm valve 3. A convex ring 312 is extended upward from the upper end of the valve core 31, and the lower end of the valve core 31 extends into the air collecting groove 23. A reset spring 5 is installed between the valve core 31 and the hollow spring column 231. Under the pushing action of the reset spring 5, a pressure-limiting deformation gap H is left between the valve core 31 and the hollow spring column 231.

[0023] A drip nozzle 1 is sealed on the valve body 2, and the drip nozzle 1 is pressed against the diaphragm valve 3. A liquid inlet gap 6 connected to the liquid inlet hole 24 is formed between the drip nozzle 1, the diaphragm valve 3 and the valve body 2. A distributor 7 is sealed on the valve body 2, and an annular gap 71 connected to the reflux groove 21 is formed between the distributor 7 and the drip nozzle 1. Regarding the connection structure between the drip nozzle 1, the diaphragm valve 3, the valve body 2 and the distributor 7, reference can be made to the authorization announcement number: CN118415813B, a gas-blocking sterile drip bottle capable of externally treating residual liquid. On this basis, the present invention makes the following changes to the drip nozzle 1 and the distributor 7: A conical platform 11 and a dripping column 12 are extended on the drip nozzle 1, an inverted conical dripping hole 121 is provided in the dripping column 12, a wedge-shaped hole 122 is provided on the large-diameter end of the dripping hole 121, a plugging hole 111 connected to the dripping hole 121 is provided on the inner side wall of the conical platform 11 of the drip nozzle 1, the lower end of the dripping column 12 extends into the plugging hole 111, the outer side wall of the lower end of the dripping column 12 is an inclined wall, and a sealing ring 112 is protruding on the side wall of the plugging hole 111, the upper end of the valve core 31 on the diaphragm valve 3 abuts against the lower end wall of the dripping column 12 under the pushing action of the reset spring 5, and the valve core 31 The inner wall of the convex ring 312 on the upper part is sealed with the outer wall of the lower end of the drip column 12, and the diaphragm valve 3 and the valve core 31 are positioned through the cooperation between the convex ring 312 and the drip column 12. The valve core 31 is sealed with the sealing ring 112. The sealing contact structure between the valve core 31 and the sealing ring 112 not only plays an auxiliary sealing role, but also improves the friction between the valve core 31 and the drip nozzle 1, thereby increasing the thrust force to which the diaphragm valve 3 is subjected when opening, so that the diaphragm valve 3 is not easily pushed open in a medium and low pressure environment; a drainage column 72 is extended on the distributor 7, and an inner conical hole is provided in the distributor 7 73, a drainage hole 721 connected with the inner tapered hole 73 is arranged in the drainage column 72, and a plurality of drainage blocks 722 are evenly distributed around the drainage hole 721. The top wall of the drainage block 722 and the top wall of the drainage hole 721 are both inclined downward from outside to inside, and a smooth transition is achieved between the two through a straight line connection. A drainage groove 74 connected with the annular gap 71 is evenly distributed around the inner wall of the distributor 7, and one end of the drainage groove 74 transitions to the hole wall of the inner tapered hole 73. The drip column 12 extends into the drainage hole 721 and abuts against the drainage block 722. The conical platform 11 is located in the inner tapered hole 73 and does not fit the inner tapered hole 73.

[0024] A bottle cap 8 is covered on the dispenser 7. Regarding the connection structure between the bottle cap 8 and the dispenser 7, reference may be made to the authorization announcement number: CN118415813B, which is an air-blocking sterile dripping bottle capable of externally treating residual liquid. On this basis, the present invention makes the following changes to the bottle cap: a cone plug 81 is provided on the bottle cap 8, which is matched with the wedge-shaped hole 122 on the dripping hole 121. The cone plug 81 passes through the drainage hole 721 and is inserted into the wedge-shaped hole 122 to seal the dripping hole 121. A gap is left between the drainage column 72 and the bottle cap 8. When the cone plug 81 is inserted into the wedge-shaped hole 122, the drainage block 722 limits the dripping column 12, thereby improving the sealing effect between the cone plug 81 and the wedge-shaped hole 122. A plurality of hollow holes 82 are evenly distributed on the circumference of the top wall of the bottle cap 8.

[0025] The sterile delivery system of ophthalmic drugs that can resist pressure difference and prevent leakage of the present invention is installed on the bottle body, and the liquid medicine is injected into the bottle body to obtain a complete sterile dropper bottle. When the sterile dropper bottle is in a horizontal state or an inverted state, the liquid medicine in the bottle body enters the liquid inlet gap 6 through the liquid inlet hole 24. When the sterile dropper bottle enters the low-pressure environment from the high-pressure environment, the liquid medicine in the bottle body will push the diaphragm valve 3 under the action of high pressure, and the diaphragm valve 3 will drive the valve core 31 to move downward, thereby opening the dripping hole 121, and the liquid medicine will enter the dripping hole 121. However, since the cone plug 81 is inserted into the wedge-shaped hole 122 to block the dripping hole 121, the liquid medicine cannot leak out from the dripping hole 121, and a good sealing effect is achieved.

[0026] When in use, the bottle cap 8 is removed, and the user presses the bottle body to squeeze out the liquid medicine. Since there is a pressure-limiting deformation gap H between the valve core 31 on the diaphragm valve 3 and the hollow spring column 231, no matter how much force the user presses the bottle body, the deformation amount of the diaphragm valve 3 is limited, so only a fixed amount of liquid medicine can be squeezed out. When the liquid medicine pushes the diaphragm valve 3 to deform, the valve core 31 on the diaphragm valve 3 no longer blocks the drip hole 121, and the liquid medicine flows outward from the drip hole 121. Since the drip hole 121 is an inverted cone shape, the liquid medicine flows from the small aperture to the large aperture in the drip hole 121, and the liquid medicine slows down the flow rate during the flow, and the liquid medicine gathers in the drip hole 12 1, and when the liquid medicine in the drip hole 121 continues to flow out, it will push the small droplets to diffuse outward and contact with the drainage block 722. The drainage block 722 divides the liquid medicine flowing out of the drip hole 121 into multiple streams and further slows down the liquid medicine. Due to the high tension of the liquid medicine, the liquid medicine is drained by the drainage block 722 and the inclined top wall of the drainage hole 721 and converges at the drainage hole 721 to form large droplets larger than the small droplets. When the liquid medicine converges into large droplets, the kinetic energy of the large droplets is further reduced. When the large droplets fall into the eyes, the large droplets have a large contact surface with the eyes, which can reduce the impact on the eyes and reduce the discomfort of the user.

[0027] When the bottle body is stopped from being squeezed, the valve core 31 will block the drip hole 121 under the pushing action of the return spring 5. The negative pressure generated when the bottle body is expanded and reset will pass through the hollow spring column 231, the sterilizing filter element 4, the air collecting groove 23, the return hole 22, the reflux groove 21, and the annular gap 71 to connect the medicine liquid remaining in the drainage hole 721 with the external air and suck it back into the isolation groove 25. The residual medicine liquid is isolated in the isolation groove 25, and the air is filtered by the sterilizing filter element 4 and then flows back to the bottle body. Since the drip column 12 in the drip nozzle 1 abuts against the drainage block 722 of the drainage hole 721, the gap between the drip column 12 and the drainage hole 721 is increased, and the The conical platform 11 in the drip nozzle 1 does not fit with the inner conical hole 73 in the distributor 7, and a large and continuous gap is left between the drip nozzle 1 and the distributor 7. Therefore, when the residual liquid medicine is refluxed by negative pressure, the flow resistance of the external air is reduced, and the reflux efficiency of the residual liquid medicine is improved. In addition, the large gap improves the air flowability between the isolation groove 25 and the external environment, and the residual liquid medicine in the isolation groove 25 can evaporate faster. When the bottle cap 8 is closed on the distributor 7, due to the hollow hole 82 on the bottle cap 8 and the cone plug 81 on the bottle cap 8 does not interfere with the drainage hole 721, the isolation groove 25 continues to maintain communication with the external environment.

[0028] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in the relevant field should understand that the specific implementation methods of the present invention can still be modified or replaced by equivalents. Any modification or equivalent replacement that does not depart from the spirit and scope of the present invention should be covered within the scope of protection of the claims of the present invention.

Claims

1. A sterile delivery system for ophthalmic drugs that can resist pressure difference and prevent leakage, comprising: A drip nozzle, a valve body, a diaphragm valve and a sterilizing filter element with hydrophobicity, a reflux groove, a return air hole, an air collecting groove, a liquid inlet hole and a plurality of interconnected isolation grooves are arranged on the valve body, a hollow spring column is arranged in the air collecting groove, a sterilizing filter element is sealed on the valve body, the diaphragm valve is fixed on the valve body and sealed on the air collecting groove, a drip nozzle is sealed on the valve body, the drip nozzle is pressed on the diaphragm valve, a liquid inlet gap connected to the liquid inlet hole is formed between the drip nozzle, the diaphragm valve and the valve body, a distributor is sealed on the valve body, an annular gap connected to the reflux groove is formed between the distributor and the drip nozzle, and the characteristic is that a conical platform and a drip column are extended on the drip nozzle, an inverted conical drip hole is arranged in the drip column, a drainage column is extended on the distributor, an inner conical hole is arranged in the distributor, and A drainage hole connected with the inner tapered hole is arranged in the drainage column, a plurality of drainage blocks are evenly distributed circumferentially in the drainage hole, a drainage groove connected with the annular gap is evenly distributed circumferentially on the inner side wall of the distributor, one end of the drainage groove transitions to the hole wall of the inner tapered hole, the dripping column extends into the drainage hole and abuts against the drainage block, the conical platform is located in the inner tapered hole and does not fit with the inner tapered hole, a valve core coaxially aligned with the hollow spring column is arranged on the diaphragm valve, the upper end of the valve core abuts against the drip nozzle to block the dripping hole, the lower end of the valve core extends into the air collecting groove, a pressure-limiting deformation gap is left between the valve core and the hollow spring column, a reset spring is mounted between the valve core and the hollow spring column, a bottle cap is covered on the distributor, a cone plug is arranged on the bottle cap, the cone plug passes through the drainage hole and is inserted into the dripping hole to block the dripping hole.

2. The aseptic delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage according to claim 1, characterized in that: A blocking hole connected to the dripping hole is arranged on the inner side wall of the conical platform of the drip nozzle, the lower end of the dripping column extends into the blocking hole, a sealing ring is protruding on the side wall of the blocking hole, the valve core rests on the lower end wall of the dripping column, and the valve core is sealed and fitted with the sealing ring.

3. The aseptic delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage according to claim 2, characterized in that: The outer side wall of the lower end of the dripping column is an inclined wall, and a convex ring is extended upwardly from the upper end of the valve core, and the inner side wall of the convex ring is in contact with the outer side wall of the lower end of the dripping column.

4. The aseptic delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage according to any one of claims 1 to 3, characterized in that: A weight-reducing hole is provided in the valve core.

5. The aseptic delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage according to claim 4, characterized in that: A wedge-shaped hole matched with the cone plug is arranged on the large-diameter end of the drip hole.

6. The aseptic delivery system for ophthalmic drugs capable of resisting pressure difference and preventing leakage according to claim 4, characterized in that: The top wall of the drainage block and the top wall of the drainage hole are both inclined downward from outside to inside, and a smooth transition is achieved between the two through a straight line connection.

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