Preparation method and preparation device of calcium dobesilate

Abstract

The invention relates to the field of preparation of calcium dobesilate, and particularly discloses a preparation method of calcium dobesilate, which comprises the following steps: a, adding anhydrous sodium sulfite into water for dissolving to form an anhydrous sodium sulfite aqueous solution; b, sieving and refining mannitol, and then stirring and mixing the mannitol with the anhydrous sodium sulfite aqueous solution formed in the step a to form a mixture; c, drying the mixture obtained in the step b until the water content is less than 1%, and finishing the granules to obtain mannitol granules; d, uniformly mixing the calcium dobesilate, the mannitol particles and the monosodium citrate lubricant according to the amount to obtain mixed particles; e, tabletting the mixed particles obtained in the step d; the preparation method of the calcium dobesilate has the beneficial effect that the quality of the calcium dobesilate can be improved.

Description

Technical Field

[0001] The present application relates to the field of preparation of calcium dobesilate, and in particular to a method for preparing calcium dobesilate. Background Art

[0002] Calcium dobesilate is a capillary protective drug. It reduces capillary permeability and platelet aggregation reaction and reduces blood viscosity by inhibiting the hyperpermeability caused by vasoactive substances (histamine, 5-hydroxytryptamine, bradykinin, hyaluronidase, prostaglandins). It is effective for a variety of diseases caused by microvascular circulatory disorders (capillary circulatory disorders). Calcium dobesilate preparations were put into clinical use in the prevention and treatment of diabetic retinopathy in the 1970s. They were included in the European Pharmacopoeia in 1997 and the British Pharmacopoeia in 1998. The drug was launched on the domestic market in June 2001. With the continuous deepening of the drug mechanism, it was found that the drug is used for kidney diseases, chronic venous insufficiency, thrombotic diseases and certain heart diseases, especially its wide application in diabetic nephropathy, indicating that it has good application prospects. In the preparation process, mannitol and anhydrous sodium sulfite aqueous solution need to be stirred and mixed; however, the current mixing equipment simply stirs and mixes the two; since the solubility of anhydrous sodium sulfite aqueous solution is low, the mixing efficiency is affected during mixing, further reducing the preparation effect; Therefore, it is necessary to design a preparation method and equipment of calcium dobesilate that can improve the preparation effect. Summary of the invention

[0003] In order to improve the problem of energy consumption, the present application provides a method for preparing calcium dobesilate.

[0004] The present application provides a method for preparing calcium dobesilate using the following technical solution: comprising the following steps: a. Add anhydrous sodium sulfite into water to dissolve it to form an anhydrous sodium sulfite aqueous solution; b. sieving and refining mannitol and then stirring and mixing with the anhydrous sodium sulfite aqueous solution formed in step a to form a mixture; c. Drying the mixture obtained in the above step b until the moisture content is less than 1% and then granulating the mixture to obtain mannitol granules; d. Mix calcium dobesilate, mannitol granules and sodium citrate lubricant in appropriate amounts to obtain mixed granules; e. Compress the mixed granules obtained in step d into tablets.

[0005] Optionally, the ratio of the amount of the anhydrous sodium sulfite aqueous solution to the amount of mannitol is 6%-9%.

[0006] By adopting the above technical solution, the filler and the anhydrous sodium sulfite solution are separately wet granulated, and the obtained granules are then mixed with other raw materials and auxiliary materials. The stability of the obtained calcium dobesilate tablets is significantly improved compared with the prior art.

[0007] Optionally, a calcium dobesilate preparation device is applied to the above-mentioned calcium dobesilate preparation method, comprising: A tank body, comprising a tank wall and a stirring chamber defined by the tank wall; A stirring member is arranged on the tank wall and located in the stirring chamber to achieve stirring and mixing of mannitol and anhydrous sodium sulfite aqueous solution; A sieving plate having sieving holes for sieving mannitol; A refiner having a grinding portion for grinding mannitol; Among them, the stirring member includes a stirring rod and a stirring blade; the stirring rod is rotatably arranged on the tank wall and axially penetrates the screening disk; the screening disk is fixedly arranged on the inner wall of the stirring chamber, and the surface of the screening disk is inclined toward the direction close to the stirring rod; the refinement member also includes a material box for loading part of mannitol, the material box is arranged on the stirring rod along the stirring rod and is arranged in a circular array along the circumferential direction of the stirring rod; a feed port is formed on the tank wall, and the feed port forms a guide channel for guiding mannitol into the material box.

[0008] Through the design of the above scheme, the raw materials of the granules can be refined and then mixed with the liquid during preparation and mixing; thereby, the mixing efficiency can be accelerated and the preparation efficiency can be improved.

[0009] Optionally, the material box is movably arranged on the stirring rod; The side wall of the stirring rod forms a guide groove for guiding the material box to approach or move away from the screening disk; the material box and the guide groove are connected by an elastic member, and the elastic member always exerts an elastic force on the material box to move away from the screening disk; Through the design of the above solution, the material box can store the raw materials for a short time, and then squeeze them with the screening disk to achieve the refinement operation; this work is carried out during mixing, which improves the preparation efficiency.

[0010] Optionally, the guide groove is movably provided with a slide block, and the slide block is fixedly connected to the material box; A magnetic piece is fixedly arranged on the slider; An electromagnet corresponding to the magnetic part is arranged in the stirring rod; Wherein, a rotating disk for supporting the electromagnet is rotatably arranged in the stirring rod so that the electromagnet corresponds to the plurality of magnetic parts alternately.

[0011] Through the above-mentioned design, the intermittent power on / off of the electromagnet makes the refinement operation also start intermittently; it can be understood that there is a short time for the material to move on the screening disc during the refinement process, which can further improve the refinement effect.

[0012] Optionally, the stirring rod has a lumen, and the lumen runs through the stirring rod in the axial direction; A rotating rod is arranged for rotation in the lumen; The rotating rod has a guide cavity for guiding the anhydrous sodium sulfite aqueous solution to flow into the stirring cavity; The end of the rotating rod inserted into the tube cavity protrudes from the stirring rod and is located at the end of the stirring cavity; the side of the rotating rod protruding from the stirring rod forms a liquid outlet.

[0013] Through the design of the above scheme, the solution is guided into the stirring chamber through the guide chamber; in this process, due to the centrifugal force generated by the rotating rod, it will not contact the refined raw materials all at once, which can avoid the generation of foam during mixing and affect the preparation effect.

[0014] Optionally, a first gear ring is provided on the rotating disk; A second gear ring is arranged on the rotating rod; Wherein, a gear that is rotatably arranged in the lumen and meshes with the first gear ring and the second gear ring simultaneously; Through the design of the above solution, the rotating disk can rotate and drive the electromagnets to correspond to multiple material boxes in sequence, so that the material boxes move in sequence to perform refinement operations.

[0015] Optionally, the side walls of any two adjacent material boxes are in contact with each other; The side of the material box forms an inclined surface; The material box is also provided with a leakage hole to allow the mannitol in the material box to fall into the screening plate.

[0016] Optionally, a heating tube is also provided in the tube wall to heat the internal temperature of the stirring chamber; A humidity sensor is also provided on the stirring liquid to detect the humidity of the mixture.

[0017] Optionally, also include: A flow monitor is arranged in the diversion cavity to detect the flow of the anhydrous sodium sulfite aqueous solution; a central processing unit, electrically connected to the flow monitor to receive and process information transmitted by the flow monitor; A deformable membrane is arranged in the flow guide cavity; A resistance rod, movably arranged on the inner wall of the guide cavity to resist the deformation membrane; A linear motor is connected to the resistance rod to drive the resistance rod to resist the deformable membrane to cause deformation; The central processing unit is also electrically connected to the humidity sensor to receive the electrical signal transmitted by the humidity sensor.

[0018] Through the design of the above scheme, the viscosity of the mixture can be automatically identified and the flow rate can be automatically adjusted according to the analysis of the central processing unit. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application; Figure 2 It is a half-section schematic diagram of the whole of the present application; Figure 3 It is the overall schematic diagram without the tank body; Figure 4 This is the installation structure diagram of the screening element; Figure 5 It is the installation structure diagram of the detailed parts; Figure 6 It is a schematic diagram of the structure of the stirring element; Figure 7 It is a schematic diagram of the structure of the grinding part; Figure 8 This is the installation structure diagram of the rotating disk; Fig. 9 yes Figure 2 The enlarged schematic diagram of point A in the middle; Fig.10 yes Figure 2 A magnified schematic diagram of point B in the middle.

[0020] Figure numerals: 1. tank body; 2. stirring member; 3. screening disk; 4. refining member; 5. stirring chamber; 6. stirring rod; 7. stirring blade; 8. fixed rod; 9. movable rod; 10. humidity sensor; 11. screening hole; 12. grinding part; 13. inclined surface; 14. feed port; 15. leakage hole; 16. guide groove; 17. slider; 18. elastic member; 19. electromagnet; 20. magnetic member; 21. tubular cavity; 22. rotating rod; 23. guide chamber; 24. liquid outlet; 25. first gear ring; 26. second gear ring; 27. gear; 28. deformation membrane; 29. ​​resistance rod; 30. linear motor; 31. rotating disk; 32. third gear ring; 33. fourth gear ring; 34. second gear; 35. hose; 36. adapter. DETAILED DESCRIPTION

[0021] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to provide a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0022] It should also be noted that, for ease of description, only the parts related to the invention are shown in the drawings. In the absence of conflict, the embodiments and features in the embodiments of the present disclosure can be combined with each other.

[0023] It should be noted that the concepts such as "first" and "second" mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not used to limit the order or interdependence of the functions performed by these devices, modules or units.

[0024] It should be noted that the modifications of "one" and "plurality" mentioned in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that unless otherwise clearly indicated in the context, it should be understood as "one or more".

[0025] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments. Embodiment 1

[0026] The present application example discloses a method for preparing calcium dobesilate, comprising the following steps: a. Add anhydrous sodium sulfite into water to dissolve it to form an anhydrous sodium sulfite aqueous solution; b. sieving and refining mannitol and then stirring and mixing with the anhydrous sodium sulfite aqueous solution formed in step a to form a mixture; c. Drying the mixture obtained in the above step b until the moisture content is less than 1% and then granulating the mixture to obtain mannitol granules; d. Mix calcium dobesilate, mannitol granules and sodium citrate lubricant in appropriate amounts to obtain mixed granules; e. Compress the mixed granules obtained in step d into tablets.

[0027] The ratio of the amount of anhydrous sodium sulfite aqueous solution to the amount of mannitol is 2:3, and the amount is a mass ratio. Embodiment 2

[0028] A method for preparing calcium dobesilate comprises the following steps: a. Add anhydrous sodium sulfite into water to dissolve it to form an anhydrous sodium sulfite aqueous solution; b. sieving and refining mannitol and then stirring and mixing with the anhydrous sodium sulfite aqueous solution formed in step a to form a mixture; c. Drying the mixture obtained in the above step b until the moisture content is less than 1% and then granulating the mixture to obtain mannitol granules; d. Mix calcium dobesilate, mannitol granules and sodium citrate lubricant in appropriate amounts to obtain mixed granules; e. Compress the mixed granules obtained in step d into tablets.

[0029] The ratio of the amount of anhydrous sodium sulfite aqueous solution to the amount of mannitol is 1:2. Embodiment 3

[0030] A method for preparing calcium dobesilate comprises the following steps: a. Add anhydrous sodium sulfite into water to dissolve it to form an anhydrous sodium sulfite aqueous solution; b. sieving and refining mannitol and then stirring and mixing with the anhydrous sodium sulfite aqueous solution formed in step a to form a mixture; c. Drying the mixture obtained in the above step b until the moisture content is less than 1% and then granulating the mixture to obtain mannitol granules; d. Mix calcium dobesilate, mannitol granules and sodium citrate lubricant in appropriate amounts to obtain mixed granules; e. Compress the mixed granules obtained in step d into tablets.

[0031] The ratio of the amount of anhydrous sodium sulfite aqueous solution to the amount of mannitol is 2:5. Embodiment 4

[0032] Reference Figures 1 to 10 , a preparation device of calcium dobesilate, applied to the preparation method of calcium dobesilate, comprising: a tank body 1, a stirring member 2, a screening disc 3, and a refinement member 4; the tank body 1 comprises a tank wall and a cylindrical stirring chamber 5 defined by the tank wall; preferably, the tank body 1 is made of stainless steel with good corrosion resistance; the stirring member 2 is arranged in the stirring chamber 5 for stirring; the mixing mannitol and anhydrous sodium sulfite aqueous solution comprises a stirring rod 6 and a stirring blade 7, specifically, the stirring rod 6 is rotatably arranged on the inner wall top wall of the stirring chamber 5, the axis of the stirring rod 6 coincides with the axis of the stirring chamber 5 on the same horizontal plane, and the bottom of the stirring rod 6 coincides with the bottom of the stirring chamber 5. There is a spacing between the parts; the stirring blades 7 are fixedly arranged on the stirring rod 6, and are arranged in a circular array along the circumferential direction of the stirring rod 6; wherein the stirring blades 7 are composed of a fixed rod 8 and a movable rod 9; the fixed rod 8 is fixedly arranged on the stirring rod 6, and one end of the movable rod 9 is hinged to the end of the fixed rod 8 away from the stirring rod 6; preferably, the shape of the movable rod 9 can fit the inner wall of the stirring chamber 5; when the stirring rod 6 rotates, the movable rod 9 will shake under the action of centrifugal force; when the centrifugal force is large, the movable rod 9 can resist the inner wall of the stirring chamber 5 to scrape the wall; increase the turbulence of the mannitol and anhydrous sodium sulfite aqueous solution, so that the mixing effect can be improved.

[0033] A humidity sensor 10 is also disposed on the stirring rod 6 , and the humidity sensor 10 can detect the humidity in the stirring chamber 5 ; thus, the viscosity of the mixture can be understood in real time.

[0034] Specifically, the screening disc 3 is fixedly arranged on the inner wall of the stirring chamber 5 for screening mannitol; the screening disc 3 is disc-shaped and extends one circle along the circumferential direction of the stirring chamber 5; the center of the screening disc 3 is axially penetrated for the stirring rod 6 to penetrate; wherein, the surface of the screening disc 3 is inclined in the direction close to the stirring rod 6, and when working, mannitol falls on the screening disc 3 and moves in the direction of the stirring rod 6; and the screening disc 3 is also provided with screening holes 11 to achieve a screening effect; the mesh number of the screening holes 11 can be designed according to actual conditions, and the present application does not make any improvement to the mesh number of the screening holes 11, so the mesh number of the screening holes 11 will not be described in detail; In another more specific embodiment, the refining member 4 has a grinding portion 12 for grinding mannitol, and the grinding portion 12 is located near the screening disc 3; preferably, the grinding portion 12 is continuous S-shaped and is evenly arrayed along the circumferential direction; the friction force can be increased to achieve a better refining effect; wherein the refining member 4 includes a material box for loading part of the mannitol, the material box is constructed in a fan shape, and is arranged in a circular array along the circumferential direction of the stirring rod 6, and the side walls of two adjacent material boxes are in contact with each other; the side edge of the material box forms a slope 13, which can make mannitol fall into the material box; in this way, mannitol will not fall directly from between two adjacent material boxes to the screening disc 3; a feed port 14 is formed on the inner upper wall of the tube wall, and the feed port 14 forms a guide channel for guiding mannitol to enter the material box; with such an arrangement, during operation, mannitol falls directly from the guide channel into the material box, and several material boxes can evenly receive mannitol; more specifically, leakage holes 15 are provided at the bottom of the material box, and the leakage holes 15 are evenly distributed along the bottom surface of the material box; when in use, the rotation of the stirring rod 6 can cause displacement between the material box and the screening disk 3 in the circumferential direction, and then the mannitol in the material box can evenly and intermittently fall onto the screening disk 3; in this way, the grinding effect can be effectively improved.

[0035] In another more specific embodiment, the material box is movably arranged on the stirring rod 6; wherein, a guide groove 16 capable of guiding the material box to approach / move away from the screening disc 3 is formed on the stirring rod 6; in this way, the grinding part 12 can squeeze the mannitol falling on the screening disc 3 and as the stirring rod 6 rotates a certain angle, the grinding effect is improved, and the mannitol is refined more finely; specifically, a slider 17 fixedly connected to the material box is movably arranged in the guide groove 16, and the slider 17 is connected to the bottom of the guide groove 16 by an elastic member 18; the elastic member 18 is a spring, which always gives the slider 17 an elastic force away from the screening disc 3; More specifically, an electromagnet 19 is installed in the guide groove 16, and the electromagnet 19 can generate magnetism after being energized; a magnetic member 20 is arranged at the bottom of the slider 17 corresponding to the electromagnet 19, and the magnetic member 20 is a permanent magnet or a metal block with magnetic conductivity; after the electromagnet 19 is energized, it can generate magnetism and then attract the magnetic member 20, so that the material box can quickly approach the screening disk 3 for a short period of extrusion and grinding; due to the continuous rotation of the stirring rod 6, the material box can rotate a part of the angle when it descends to extrude the screening disk 3, thereby improving the effect of fine grinding; on this basis, a rotating disk 31 for supporting the electromagnet 19 is rotatably arranged in the stirring rod 6, so that it can correspond alternately with multiple magnetic members 20; with such a configuration, multiple material boxes can intermittently resist the mannitol on the screening disk 3, thereby improving the uniformity of refinement.

[0036] In another more specific embodiment, the end of the stirring rod 6 penetrates along the axial direction to form a tubular cavity 21; wherein a rotating rod 22 is rotatably arranged in the tubular cavity 21; a diversion cavity 23 is formed in the rotating rod 22, and the diversion cavity 23 can divert the anhydrous sodium sulfite aqueous solution into the stirring cavity 5 to mix with the refined mannitol; specifically, an adapter 35 is rotatably arranged on the diversion cavity 23, and a hose 36 is installed on the adapter 35 to connect with a container containing anhydrous sodium sulfite aqueous solution so as to pour the anhydrous sodium sulfite aqueous solution into the diversion cavity 23; the rotating rod 22 is inserted into the end of the tubular cavity 21 The protruding stirring rod 6 is located at the end portion of the stirring chamber 5, and the side wall of the protruding portion forms a liquid outlet 24; it can be understood that when the anhydrous sodium sulfite aqueous solution enters the tube cavity 21, it will flow toward the bottom of the stirring chamber 5 under the action of gravity, and will be thrown out from the liquid outlet 24 under the action of centrifugal force, and will contact with the refined mannitol in the space of the stirring chamber 5 to form a mixture; then the mixture falls to the bottom of the stirring chamber 5 and slowly accumulates and is stirred; through the design of the above scheme, the phenomenon of foaming after the powdery particles come into contact with the liquid can be effectively avoided, and the mixing effect is improved.

[0037] More specifically, a first gear ring 25 is arranged on the rotating disk 31, and a second gear ring 26 is arranged on the rotating rod 22; wherein, the first gear ring 25 and the second gear ring 26 are arranged coaxially; the gear number ratio of the first gear ring 25 and the second gear ring 26 is 1:3, so that a speed difference between the rotating disk 31 and the rotating rod 22 is formed; on this basis, a gear 27 is arranged between the first gear ring 25 and the second gear ring 26, and the gear 27 can be engaged with the first gear ring 25 and the second gear ring 26 at the same time; wherein, a third gear ring 32 is fixedly arranged on the rotating rod 22, and a fourth gear ring 33 is arranged on the stirring rod 6; a second gear 34 is arranged between the third gear ring 32 and the fourth gear ring 33; the second gear 34 is driven by a motor; with such an arrangement, the first gear ring 32 and the fourth gear ring 33 can rotate the rotating rod 22 and the stirring rod 6; then, under the action of the gear 27, the first gear ring 25 is rotated, so that the rotation of the rotating disk 31 is realized.

[0038] In another more specific embodiment, a heating tube is further provided on the tank wall, and the heating tube can generate heat to control the temperature of the stirring chamber 5 after being energized; different stirring temperatures can be set according to different preparation process requirements, thereby improving the preparation effect.

[0039] In another more specific embodiment, the preparation device of calcium dobesilate also includes a flow monitor, a central processing unit, a deformable membrane 28, and a linear motor 30; the flow monitor is fixedly arranged in the diversion cavity 23, and can detect the flow of the anhydrous sodium sulfite aqueous solution flowing through the diversion cavity 23 in real time; the inner wall of the diversion cavity 23 is fixedly provided with a deformable membrane 28, and the fixing method can be, for example, bonding, snap connection, and additional threaded connection pressing sheet clamping and locking the deformable membrane 28; the deformable membrane 28 can be limited in the axial direction after being fixed; the deformable membrane 28 can be made of rubber, silicone, etc., which can be deformed under the action of external force and can basically recover to the state before deformation after the external force disappears; wherein, the anhydrous sodium sulfite aqueous solution flows through the deformable membrane 28; it can be understood that when the deformable membrane 28 is deformed, the flow of the anhydrous sodium sulfite aqueous solution will decrease; in this way, the flow of the anhydrous sodium sulfite aqueous solution can be controlled according to different production processes or different mannitol fractions; On this basis, a resistance rod 29 is arranged on the flow guide cavity 23, and the resistance rod 29 is driven by a linear motor 30; after the linear motor 30 is started, it can drive the resistance rod 29 to resist the deformable membrane 28 so that the deformable membrane 28 is deformed to change the flow; the central processing unit is electrically connected to the flow monitor to receive and process the information transmitted by the flow monitor; after receiving the information, the central processing unit makes an analysis to control the start of the linear motor 30.

[0040] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", etc. should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0041] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A method for preparing calcium dobesilate, characterized in that: The following steps are involved: a. Add anhydrous sodium sulfite into water to dissolve it to form an anhydrous sodium sulfite aqueous solution; b. sieving and refining mannitol and then stirring and mixing with the anhydrous sodium sulfite aqueous solution formed in step a to form a mixture; c. Drying the mixture obtained in the above step b until the moisture content is less than 1% and then granulating the mixture to obtain mannitol granules; d. Mix calcium dobesilate, mannitol granules and sodium citrate lubricant in appropriate amounts to obtain mixed granules; e. Compress the mixed granules obtained in step d into tablets.

2. The method for preparing calcium dobesilate according to claim 1, wherein: The ratio of the amount of the anhydrous sodium sulfite aqueous solution to the amount of mannitol is 6%-9%.

3. A preparation device for calcium dobesilate, characterized in that: The preparation method of calcium dobesilate applied to any one of claims 1 to 2 comprises: A tank body, comprising a tank wall and a stirring chamber defined by the tank wall; A stirring member, disposed on the tank wall and located in the stirring chamber to achieve stirring and mixing of mannitol and anhydrous sodium sulfite aqueous solution; A sieving plate having sieving holes for sieving mannitol; A refiner having a grinding portion for grinding mannitol; Wherein, the stirring member includes a stirring rod and a stirring blade; the stirring rod is rotatably arranged on the tank wall and axially penetrates the screening disk; the screening disk is fixedly arranged on the inner wall of the stirring chamber, and the surface of the screening disk is inclined toward the direction close to the stirring rod; the refining member also includes a material box for loading part of mannitol, the material box is arranged on the stirring rod along the stirring rod and is arranged in a circular array along the circumferential direction of the stirring rod; a feed port is formed on the tank wall, and the feed port forms a guide channel for guiding mannitol into the material box.

4. A preparation device for calcium dobesilate according to claim 3, characterized in that: The material box is movably arranged on the stirring rod; Wherein, the side wall of the stirring rod forms a guide groove for guiding the material box to approach / move away from the screening disk; the material box and the guide groove are connected by an elastic member, and the elastic member always gives the material box an elastic force to move away from the screening disk.

5. A preparation device for calcium dobesilate according to claim 4, characterized in that: The guide groove is movably provided with a slider, and the slider is fixedly connected to the material box; A magnetic member is fixedly arranged on the slider; An electromagnet corresponding to the magnetic member is arranged in the stirring rod; Wherein, a rotating disk for supporting the electromagnet is rotatably arranged inside the stirring rod so that the electromagnet corresponds to the plurality of magnetic parts alternately.

6. A preparation device for calcium dobesilate according to claim 5, characterized in that: The stirring rod has a lumen, and the lumen runs through the stirring rod in the axial direction; A rotating rod is rotatably arranged in the lumen; The rotating rod has a guide cavity to guide the anhydrous sodium sulfite aqueous solution into the stirring cavity; The end of the rotating rod inserted into the tube cavity protrudes from the end of the stirring rod located in the stirring cavity; the rotating rod protrudes from the side of the stirring rod to form a liquid outlet.

7. A preparation device for calcium dobesilate according to claim 6, characterized in that: A first gear ring is arranged on the rotating disk; A second gear ring is arranged on the rotating rod; Wherein, a gear is rotatably arranged in the tubular cavity and meshes with the first gear ring and the second gear ring at the same time.

8. A preparation device for calcium dobesilate according to claim 3, characterized in that: The side walls of any two adjacent material boxes are in contact with each other; The side edge of the material box forms an inclined surface; The material box is also provided with a leakage hole to allow the mannitol in the material box to fall into the screening plate.

9. A preparation device for calcium dobesilate according to claim 4, characterized in that: A heating tube is also arranged in the tube wall to heat the internal temperature of the stirring chamber; The stirring liquid is also provided with a humidity sensor to detect the humidity of the mixture.

10. A preparation device for calcium dobesilate according to any one of claims 3 to 9, characterized in that: Also includes: A flow monitor is arranged in the diversion cavity to detect the flow of the anhydrous sodium sulfite aqueous solution; a central processing unit, electrically connected to the flow monitor to receive and process information transmitted by the flow monitor; A deformable membrane, disposed in the flow guiding cavity; A resistance rod, movably disposed on the inner wall of the guide cavity to resist the deformable membrane; A linear motor connected to the abutment rod to drive the abutment rod to abut against the deformable film to cause deformation; Wherein, the central processing unit is also electrically connected to the humidity sensor to receive the electrical signal transmitted by the humidity sensor.

Images