Decoction containing ten-shaped kidney, seven kidney and herba polygoni cuspidati and preparation method thereof

Abstract

The invention discloses a Szechwan-lian-kidney-herb decoction and a preparation method thereof. The invention belongs to the technical field of traditional Chinese medicines, and through combination of dynamic countercurrent extraction and membrane filtration technologies, the extraction rate and purity of effective components are significantly improved, and stable efficacy and easy absorption are ensured; meanwhile, a plurality of premna microphylla and auxiliary medicinal materials are preferably selected and are matched according to a specific proportion, so that the multiple effects of tonifying the kidney, tonifying qi and regulating yin and yang are achieved, and the conditioning effect is comprehensively improved; by adding the first compound extract, the second compound extract and the third compound extract, the effect of tonifying kidney and qi is further enhanced, meanwhile, the taste is improved, and the taking experience is improved; and dynamic countercurrent extraction and low-temperature concentration technologies are adopted, so that the preparation process is greatly simplified, the production cost is reduced, and modern large-scale production requirements are met.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically refers to a Shiyang Shen Qi Shen Cao decoction and a preparation method thereof. Background Art

[0002] As an important part of traditional Chinese medicine culture, Chinese herbal decoction has been widely used in folk diet and modern medicine, and its preparation method and application effect have gradually become a research hotspot. Wenzhou's traditional "Ten Kinds of Kidney Grass Soup" is a Chinese herbal decoction that cleverly matches seven kinds of kidney grass (radish head kidney, dragon bud kidney, cotton kidney, white leaf kidney, red leaf kidney, litchi kidney, flower wheat kidney) and three kinds of grass (chicken shit vine, black bean pea, sword bean shell). It is deeply respected by the people because of its unique effect of tonifying the kidney and replenishing qi and harmonizing yin and yang. However, the technical solutions of similar Chinese herbal decoctions in the prior art still have significant deficiencies in terms of medicinal material selection, compatibility ratio, preparation process and drug effect optimization, and it is difficult to fully meet the needs of modern consumers for efficient, convenient and standardized Chinese herbal decoctions.

[0003] After searching, it was found that the patent with publication number CN103432337B involves a Chinese medicine decoction composed of medicinal materials such as Angelica dahurica, Cortex qin, Phellodendron chinense, Angelica sinensis, White Peony Root, Chinese Yam, and Herba Pteris Coptidis and its preparation method, and its preparation steps include medicinal material selection, cleaning, sterilization, crushing, mixing, soaking, heating and reflux, etc. However, this technical solution is mainly designed for specific diseases, and does not fully consider the concept of medicine and food being of the same origin. In addition, the types of medicinal materials and the proportion of compatibility are relatively single, and lack a systematic conditioning effect on kidney deficiency-related symptoms. In addition, although its preparation process is detailed, the operation is cumbersome, and it is difficult to adapt to the needs of modern large-scale production, and it fails to reflect the inheritance and innovation of the unique formula of Wenzhou's traditional "Ten Kinds of Kidney Grass Soup".

[0004] Another patent with publication number CN106937939B provides a method for preparing Chinese herbal decoctions for industrial production, including the steps of decoction, cooling, shearing and crushing, filtering, homogenization, canning and high-temperature sterilization. This technical solution emphasizes the absorption rate and shelf life of Chinese herbal decoctions and has a high industrial application value. However, this solution does not involve the core medicinal material combination of Wenzhou's traditional "Ten Kinds of Kidney Grass Soup", and its formula design lacks specificity and cannot achieve comprehensive conditioning of kidney deficiency-related symptoms. At the same time, multiple heating and homogenization processes during its preparation process may destroy the effective ingredients of some medicinal materials, affecting the stability and safety of the efficacy.

[0005] The above problems show that the existing technical solutions for Chinese herbal decoctions still have obvious deficiencies in terms of medicinal material selection and compatibility, preparation process optimization, and drug efficacy stability. Therefore, it is urgent to develop a new type of "Shiyang Shen Qishencao Decoction and its preparation method", combining the unique formula of Wenzhou's traditional "Shiyang Shencao Decoction", optimizing the compatibility ratio of medicinal materials, simplifying the preparation process, and improving drug efficacy stability and applicability, so as to meet the needs of modern consumers for efficient, safe, and convenient Chinese herbal decoctions. Summary of the invention

[0006] The purpose of the present invention is to provide a Ten-Style Kidney and Seven-Kidney Grass Decoction and a preparation method thereof. The present invention aims to optimize the compatibility ratio of medicinal materials, simplify the preparation process, and improve the stability and applicability of the drug efficacy; the present invention combines dynamic countercurrent extraction with membrane filtration technology to significantly improve the extraction rate and purity of effective ingredients, ensuring that the drug efficacy is stable and easy to absorb; the present invention preferably selects a variety of kidney grasses and auxiliary medicinal materials, and matches them in a specific ratio, taking into account the multiple functions of tonifying the kidney, invigorating qi, and harmonizing yin and yang, and comprehensively improving the conditioning effect; the present invention further enhances the effects of tonifying the kidney and invigorating qi by adding a first compound extract, a second compound extract, and a third compound extract, while improving the taste and enhancing the taking experience; the present invention adopts dynamic countercurrent extraction and low-temperature concentration technology to greatly simplify the preparation process, reduce production costs, and adapt to the needs of modern large-scale production.

[0007] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: a kind of ten kinds of kidney and seven kinds of kidney grass soup and a preparation method thereof, wherein the ten kinds of kidney and seven kinds of kidney grass soup comprises the following components in parts by weight: 10-20 parts of radish kidney, 10-20 parts of dragon bud kidney, 12-25 parts of cotton kidney, 8-20 parts of white paired leaf kidney, 10-20 parts of red paired leaf kidney, 12-23 parts of litchi kidney, 5-15 parts of flower wheat kidney, 10-20 parts of smilax glabra, 8-15 parts of black bean pea, 7-15 parts of sword bean shell, 0.2-1.8 parts of the first compound extract, 0.1-1.0 parts of the second compound extract, 0.01-0.3 parts of the third compound extract and 0.05-0.6 parts of natural flavoring.

[0008] Preferably, the Ten Kinds of Kidneys and Seven Kidney Grasses Soup includes the following components in parts by weight: 13-16 parts of radish kidney, 13-16 parts of dragon bud kidney, 12-16 parts of cotton kidney, 10-15 parts of white leaf kidney, 12-16 parts of red leaf kidney, 15-20 parts of lychee kidney, 8-12 parts of flower wheat kidney, 15-20 parts of millet dung vine, 10-15 parts of black bean pea, 8-12 parts of sword bean shell, 0.5-1.5 parts of the first compound extract, 0.2-0.8 parts of the second compound extract, 0.05-0.2 parts of the third compound extract and 0.1-0.5 parts of natural flavoring.

[0009] Preferably, the first compound extract is obtained by compounding astragalus polysaccharide, wolfberry polysaccharide, poria polysaccharide, glycyrrhizic acid and tanshinone in a weight ratio of (3.0-4.0):(1.5-2.5):(0.8-1.2):(1.0-1.5):(0.5-0.9).

[0010] Preferably, the second compound extract is obtained by compounding icariin, eucommia bark extract, cornus officinalis, schisandrae alcohol A and rehmannia glutinosa polysaccharide in a weight ratio of (1.2-1.8):(0.6-1.0):(0.3-0.7):(1.5-2.0):(0.8-1.2).

[0011] Preferably, the third compound extract is obtained by compounding Ganoderma lucidum spore powder and Cordyceps sinensis extract in a weight ratio of (1.0-1.5):1.

[0012] Preferably, the natural flavoring agent is prepared from a first honey, a second honey and citric acid in a weight ratio of (5-8):(2-4):(1-3); the first honey includes multi-flower honey; the second honey includes acacia honey; and the citric acid includes food-grade anhydrous citric acid.

[0013] The present invention also provides a method for preparing the Shiyangshen Qishencao decoction, which comprises the following steps:

[0014] (1) washing, slicing and sterilizing radish kidney, dragon bud kidney, cotton kidney, white leaf kidney, red leaf kidney, litchi kidney, flower wheat kidney, scutellaria baicalensis, black bean pea and sword bean shell to obtain pretreated medicinal materials;

[0015] (2) mixing the pretreated medicinal material with water in a weight ratio of 1:(8-12), performing dynamic countercurrent extraction to obtain an extract; performing membrane filtration on the extract, and then performing low-temperature concentration to obtain a concentrate;

[0016] (3) Adding the first compound extract, the second compound extract, the third compound extract and the natural flavoring agent into the concentrated solution and stirring and mixing to obtain the Ten-kind Kidney and Seven-Kidney Grass Soup.

[0017] The beneficial effects achieved by the present invention using the above structure are as follows: (1) The present invention significantly improves the extraction rate and purity of the effective ingredients by combining dynamic countercurrent extraction with membrane filtration technology, ensuring that the efficacy is stable and easy to absorb; (2) The present invention preferably selects a variety of kidney grasses and auxiliary medicinal materials, and combines them according to a specific proportion, taking into account the multiple functions of tonifying the kidney, invigorating qi, and harmonizing yin and yang, thereby comprehensively improving the conditioning effect; (3) The present invention further enhances the effects of tonifying the kidney and invigorating qi by adding the first compound extract, the second compound extract, and the third compound extract, while improving the taste and enhancing the taking experience; (4) The present invention adopts dynamic countercurrent extraction and low-temperature concentration technology to greatly simplify the preparation process, reduce production costs, and adapt to the needs of modern large-scale production.

[0018] The kidney is the innate foundation of the human body. It stores essence and qi, controls reproduction, controls bone marrow production, and evaporates and excretes water. The kidney opens to the ear. The kidney meridian is yin, and kidney qi is yang. Only when yin and yang are balanced can the normal activities of the internal organs be maintained. Kidney diseases are caused by deficiency. The Ten Kinds of Kidney Herb Soup, with its unique food and nourishment combination, harmonizes yin and yang, replenishes deficiency and benefits the kidney, and has the same origin as medicine and food. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 Serum testosterone levels in mice.

[0020] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0022] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0023] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0024] Example 1

[0025] A kind of ten kinds of kidney and seven kidney grass soup and its preparation method

[0026] The Ten Kinds of Kidneys and Seven Kidney Herbs Soup includes the following components in parts by weight: 13 parts of radish kidney, 16 parts of dragon bud kidney, 12 parts of cotton kidney, 15 parts of white leaf kidney, 12 parts of red leaf kidney, 20 parts of litchi kidney, 8 parts of flower wheat kidney, 20 parts of smilax glabra, 10 parts of black bean pea, 12 parts of sword bean shell, 0.5 parts of the first compound extract, 0.8 parts of the second compound extract, 0.05 parts of the third compound extract and 0.5 parts of natural flavoring.

[0027] Among them, the first compound extract is obtained by compounding astragalus polysaccharide, wolfberry polysaccharide, poria polysaccharide, glycyrrhizic acid and tanshinone in a weight ratio of 3.0:2.5:0.8:1.5:0.5.

[0028] The second compound extract is obtained by compounding icariin, eucommia bark extract, cornus officinalis, schisandrae alcohol A and rehmannia glutinosa polysaccharide in a weight ratio of 1.2:1.0:0.3:2.0:0.8.

[0029] The third compound extract is obtained by compounding Ganoderma lucidum spore powder and Cordyceps sinensis extract in a weight ratio of 1:1.

[0030] The natural flavoring agent is prepared from a first honey, a second honey and citric acid in a weight ratio of 5:4:1; the first honey is multi-flower honey; the second honey is acacia honey; and the citric acid is food-grade anhydrous citric acid.

[0031] The present invention also provides a method for preparing the Shiyangshen Qishencao decoction, which comprises the following steps:

[0032] (1) washing, slicing and sterilizing radish kidney, dragon bud kidney, cotton kidney, white leaf kidney, red leaf kidney, litchi kidney, flower wheat kidney, scutellaria baicalensis, black bean pea and sword bean shell to obtain pretreated medicinal materials;

[0033] (2) mixing the pretreated medicinal material with water in a weight ratio of 1:(8-12), performing dynamic countercurrent extraction to obtain an extract; performing membrane filtration on the extract, and then performing low-temperature concentration to obtain a concentrate;

[0034] (3) Adding the first compound extract, the second compound extract, the third compound extract and the natural flavoring agent into the concentrated solution and stirring and mixing to obtain the Ten-kind Kidney and Seven-Kidney Grass Soup.

[0035] Example 2

[0036] A kind of ten kinds of kidney and seven kidney grass soup and its preparation method

[0037] The Ten Kinds of Kidneys and Seven Kidney Herbs Soup includes the following components in parts by weight: 16 parts of radish kidney, 13 parts of dragon bud kidney, 16 parts of cotton kidney, 10 parts of white leaf kidney, 16 parts of red leaf kidney, 15 parts of litchi kidney, 12 parts of flower wheat kidney, 15 parts of clover dung vine, 15 parts of black bean pea, 8 parts of sword bean shell, 1.5 parts of the first compound extract, 0.2 parts of the second compound extract, 0.2 parts of the third compound extract and 0.1 parts of natural flavoring.

[0038] Among them, the first compound extract is obtained by compounding astragalus polysaccharide, wolfberry polysaccharide, poria polysaccharide, glycyrrhizic acid and tanshinone in a weight ratio of 4.0:1.5:1.2:1.0:0.5.

[0039] Wherein, the second compound extract is obtained by compounding icariin, eucommia bark extract, cornus officinalis, schisandrae alcohol A and rehmannia glutinosa polysaccharide in a weight ratio of 1.8:0.6):0.7:1.5):1.2.

[0040] The third compound extract is obtained by compounding Ganoderma lucidum spore powder and Cordyceps sinensis extract in a weight ratio of 1.5:1.

[0041] The natural flavoring agent is prepared from a first honey, a second honey and citric acid in a weight ratio of 8:2:3; the first honey is multi-flower honey; the second honey is acacia honey; and the citric acid is food-grade anhydrous citric acid.

[0042] The present invention also provides a method for preparing Shiyangshen Qishencao Decoction, and the preparation method is carried out with reference to Example 1.

[0043] Example 3

[0044] A kind of ten kinds of kidney and seven kidney grass soup and its preparation method

[0045] The Ten Kinds of Kidneys and Seven Kidney Herbs Soup includes the following components in parts by weight: 15 parts of radish kidney, 15 parts of dragon bud kidney, 15 parts of cotton kidney, 15 parts of white paired leaf kidney, 15 parts of red paired leaf kidney, 15 parts of litchi kidney, 10 parts of flower wheat kidney, 15 parts of clover vine, 15 parts of black bean pea, 10 parts of sword bean shell, 1 part of the first compound extract, 0.6 parts of the second compound extract, 0.1 parts of the third compound extract and 0.2 parts of natural flavoring.

[0046] Among them, the first compound extract is obtained by compounding astragalus polysaccharide, wolfberry polysaccharide, poria polysaccharide, glycyrrhizic acid and tanshinone in a weight ratio of 3.5:2.0:1.0:1.2:0.7.

[0047] The second compound extract is obtained by compounding icariin, eucommia bark extract, cornus officinalis, schisandrae alcohol A and rehmannia glutinosa polysaccharide in a weight ratio of 1.6:0.8:0.5:1.8:1.0.

[0048] Preferably, the third compound extract is obtained by compounding Ganoderma lucidum spore powder and Cordyceps sinensis extract in a weight ratio of 1.2:1.

[0049] Preferably, the natural flavoring agent is prepared by using a first honey, a second honey and citric acid in a weight ratio of 7:3:2; the first honey includes multi-flower honey; the second honey includes acacia honey; and the citric acid includes food-grade anhydrous citric acid.

[0050] The present invention also provides a method for preparing Shiyangshen Qishencao Decoction, and the preparation method is carried out with reference to Example 1.

[0051] Experimental Example 1

[0052] 80 healthy male mice were selected and randomly divided into 4 groups, 20 mice in each group, namely, the decoction group of Example 1, the decoction group of Example 2, the decoction group of Example 3 and the control group; the mice in the control group were given regular drinking water, and the decoction groups of Examples 1-3 were gavaged with the corresponding Ten Samples of Kidney and Seven Kidney Grass Decoctions at a dose of 0.2 ml / 10 g body weight daily for 30 consecutive days. After the experiment, the testosterone level in the mouse serum was detected.

[0053] Result analysis: Figure 1 As shown, the testosterone content of the decoction groups of Examples 1-3 was higher than that of the control group, among which the testosterone content of the decoction group of Example 3 was the highest.

[0054] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0055] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A ten-kind kidney and seven-shencao soup, characterized by: The Ten Kinds of Kidneys and Seven Kidney Herbs Soup includes the following components in parts by weight: 10-20 parts of radish kidney, 10-20 parts of dragon bud kidney, 12-25 parts of cotton kidney, 8-20 parts of white leaf kidney, 10-20 parts of red leaf kidney, 12-23 parts of litchi kidney, 5-15 parts of flower wheat kidney, 10-20 parts of smilax glabra, 8-15 parts of black bean pea, 7-15 parts of sword bean shell, 0.2-1.8 parts of the first compound extract, 0.1-1.0 parts of the second compound extract, 0.01-0.3 parts of the third compound extract and 0.05-0.6 parts of natural flavoring.

2. The Shiyang Shen Qi Shen Cao decoction according to claim 1, characterized in that: The Ten Kinds of Kidneys and Seven Kidney Herbs Soup includes the following components in parts by weight: 13-16 parts of radish kidney, 13-16 parts of dragon bud kidney, 12-16 parts of cotton kidney, 10-15 parts of white leaf kidney, 12-16 parts of red leaf kidney, 15-20 parts of lychee kidney, 8-12 parts of flower wheat kidney, 15-20 parts of smilax glabra, 10-15 parts of black bean pea, 8-12 parts of sword bean shell, 0.5-1.5 parts of a first compound extract, 0.2-0.8 parts of a second compound extract, 0.05-0.2 parts of a third compound extract and 0.1-0.5 parts of a natural flavoring agent.

3. The Shiyang Shenqi Shencao Decoction according to claim 2, characterized in that: The first compound extract is obtained by compounding astragalus polysaccharide, wolfberry polysaccharide, tuckahoe polysaccharide, glycyrrhizic acid and tanshinone in a weight ratio of (3.0-4.0):(1.5-2.5):(0.8-1.2):(1.0-1.5):(0.5-0.9).

4. The Shiyang Shen Qi Shen Cao decoction according to claim 3, characterized in that: The second compound extract is obtained by compounding icariin, eucommia bark extract, cornus officinalis glycoside, schisandrae alcohol A and rehmannia glutinosa polysaccharide in a weight ratio of (1.2-1.8):(0.6-1.0):(0.3-0.7):(1.5-2.0):(0.8-1.2).

5. The Shiyang Shen Qi Shen Cao decoction according to claim 4, characterized in that: The third compound extract is obtained by compounding Ganoderma lucidum spore powder and Cordyceps sinensis extract in a weight ratio of (1.0-1.5):

1.

6. The Shiyang Shen Qi Shen Cao decoction according to claim 5, characterized in that: The natural flavoring agent is prepared from a first honey, a second honey and citric acid in a weight ratio of (5-8):(2-4):(1-3); the first honey includes multi-flower honey; the second honey includes acacia honey; and the citric acid includes food-grade anhydrous citric acid.

7. A method for preparing the Shiyangshenqishencao decoction according to claim 6, characterized in that: The preparation method comprises the following steps: (1) washing, slicing and sterilizing radish kidney, dragon bud kidney, cotton kidney, white leaf kidney, red leaf kidney, litchi kidney, flower wheat kidney, scutellaria baicalensis, black bean pea and sword bean shell to obtain pretreated medicinal materials; (2) mixing the pretreated medicinal material with water in a weight ratio of 1:(8-12), performing dynamic countercurrent extraction to obtain an extract; performing membrane filtration on the extract, and then performing low-temperature concentration to obtain a concentrate; (3) Adding the first compound extract, the second compound extract, the third compound extract and the natural flavoring agent into the concentrated solution and stirring and mixing to obtain the Ten-kind Kidney and Seven-Kidney Grass Soup.

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