Traditional Chinese medicine composition capable of converting HPV positive to negative and traditional Chinese medicine preparation

Abstract

The traditional Chinese medicine composition is prepared from the following components in parts by mass: 27 to 33 parts of herba hedyotidis diffusae, 13 to 17 parts of raw coix seeds, 8 to 12 parts of fried rhizoma atractylodis, 8 to 12 parts of cortex phellodendri, 8 to 12 parts of radix cyathulae, 8 to 12 parts of raw radix astragali seu hedysari, 8 to 12 parts of rhizoma bletillae, 8 to 12 parts of flos chrysanthemi indici, 8 to 12 parts of radix isatidis, 8 to 12 parts of herba verbenae and 8 to 12 parts of herba menthae. The traditional Chinese medicine composition has a remarkable curative effect on high-risk or low-risk patients in treatment of HPV infection, the clinical cure rate of a treatment group using the traditional Chinese medicine composition is higher, and the patients are not prone to relapse.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition and a traditional Chinese medicine preparation, and in particular to a traditional Chinese medicine composition and a traditional Chinese medicine preparation capable of converting HPV positive to negative. Background Art

[0002] Human papillomavirus, abbreviated as HPV, is a spherical DNA virus that is widely present in nature and has humans as its only host. Currently, there are only more than 150 known HPV subtypes, which can be divided into low-risk and high-risk types according to the severity of the diseases they cause. The clinical symptoms of the disease include various types of skin warts, such as common warts, flat warts, plantar warts, etc. High-risk HPV can cause a variety of tumors, such as cervical cancer, anal cancer, penile cancer, bladder cancer, oral cancer, tonsil cancer, etc.

[0003] In the existing TCM treatment scheme, cervical cancer caused by HPV is classified as a leukorrhea disease. It is believed that its pathogenesis is mostly based on spleen deficiency, with liver depression and spleen deficiency as the key to the pathogenesis, and dampness, toxins, and blood stasis as the initiating factors of the disease. Therefore, a treatment scheme that not only soothes the liver and strengthens the spleen but also does not forget the combination of blood circulation and blood stasis, and antiviral drugs is adopted. For multiple plantar warts caused by HPV, the main treatments are to break blood and promote qi, promote blood circulation and disperse blood stasis, clear away heat and detoxify, supplemented by strengthening the spleen and removing dampness. The existing treatment ideas are often "the right medicine for the right disease", and the treatment is carried out according to the symptoms. If the disease is in the skin, the surface toxins are cleared, if it is in the skin, the invasion of dampness is prevented, and if it is in the body, the internal organs are adjusted and the blood stasis is dispersed. This treatment idea can achieve certain therapeutic effects, but it often ignores the process of disease development. Therefore, in response to the invasion of HPV, the present invention attempts to treat with a new treatment idea, hoping to correct the root cause and fundamentally strengthen the body and eliminate evil. Summary of the invention

[0004] The purpose of the present invention is to propose a Chinese medicine composition and Chinese medicine preparation for converting HPV positive to negative from the perspective of clearing the root cause and strengthening the body to eliminate evil, which can effectively convert HPV positive to negative and prevent recurrence.

[0005] The technical solution adopted by the present invention provides a traditional Chinese medicine composition capable of converting HPV positive to negative. The key point is that, measured by weight, the traditional Chinese medicine composition is prepared from 27 to 33 parts of oldenlandia diffusa, 13 to 17 parts of raw coix seeds, 8 to 12 parts of stir-fried atractylodes, 8 to 12 parts of phellodendron, 8 to 12 parts of cyathula, 8 to 12 parts of raw astragalus, 8 to 12 parts of bletilla striata, 8 to 12 parts of wild chrysanthemum, 8 to 12 parts of isatis root, 8 to 12 parts of verbena and 8 to 12 parts of mint.

[0006] Preferably, the above-mentioned traditional Chinese medicine composition is made of 30 parts of Hedyotis diffusa, 15 parts of raw coix seeds, 10 parts of stir-fried atractylodes, 10 parts of phellodendron, 10 parts of cyathula, 10 parts of raw astragalus, 10 parts of bletilla striata, 10 parts of wild chrysanthemum, 10 parts of isatis root, 10 parts of verbena and 10 parts of mint, by weight.

[0007] Specifically, soak the above-mentioned traditional Chinese medicine composition in cold water for 30min to 50min, simmer for 20min to 30min from the beginning of boiling, simmer for 15min to 25min, filter out the residue to obtain the decoction, and take it orally twice a day, morning and evening.

[0008] A Chinese medicine preparation capable of converting HPV positive to negative, using the above Chinese medicine composition as Chinese medicinal materials, the key is that the above Chinese medicine preparation is a water pill, and the specific preparation steps include:

[0009] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powder, and mix them according to the formula ratio;

[0010] S2. Adjust moisture: add water, wine or honey, and stir until it sticks together;

[0011] S3. Pilling: Make pills using a pilling machine or a manual pilling machine, and package the finished products.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] The present invention believes that although HPV infection can cause various types of diseases in different populations, so that the onset sites and symptoms of the diseases vary significantly, HPV can be attributed to exogenous evil in the final analysis. In the field of traditional Chinese medicine, exogenous evil specifically refers to pathogenic factors that invade the human body from the outside, such as wind, cold, heat, dampness, dryness, fire, and pestilence. The present invention believes that HPV is essentially a pestilence. "Quyi Shuo" records that "it is called exogenous evil because it is not self-correcting from the inside. The heart has no master, so it is called guest qi."

[0014] Therefore, the present invention adopts the idea of ​​correcting the root and clearing the source, strengthening the body and eliminating the evil, and conducts a deep analysis of the pathogenesis of HPV infection. It is believed that HPV infection is the pathogenic factor invading the body from the outside, and its invasion pathway is nothing more than entering from the skin and fur to the meridians and internal organs, or entering from the mouth and nose and being easily infected. In the course of the development of the disease, lesions occurring in any part of the body can be transmitted through the meridians, from top to bottom, and between the internal organs. For example, as stated in "Suwen Tiaojing Lun Pibu Lun", "the injuries caused by wind and rain first invade the skin, and are transmitted to the sun vessels. If the sun vessels are full, they are transmitted to the collateral vessels." "If the collateral vessels are full, they are injected into the meridians. If the meridians are full, they enter the internal organs."

[0015] The effects of Hedyotis diffusa are clearing away heat and detoxifying, promoting dampness and relieving stranguria, eliminating carbuncle and dispersing nodules, and it is often used together with Scutellaria barbata for anti-cancer and anti-tumor, but the two together will damage the spleen and stomach, so it is not suitable for patients to take in large quantities for a long time. In the present invention, only Hedyotis diffusa is used as the main ingredient, and raw coix seed, stir-fried atractylodes and other spleen-strengthening drugs are supplemented, which is more suitable for patients to take for a long time.

[0016] In addition, considering that the spleen is responsible for transportation and transformation, based on the source-clearing idea of ​​the present invention, it is also necessary to transport and excrete water and moisture. Stir-fried Atractylodes has the effects of drying dampness and strengthening the spleen, dispelling wind and cold, and relieving damp-heat arthralgia, and has a certain relieving effect on dampness and arthralgia. Raw Coix seeds enter the spleen, lung, and kidney meridians, and can strengthen the spleen, nourish the lungs, clear heat, and promote dampness.

[0017] Based on the original idea, raw astragalus can replenish the body's qi and raise yang, and is the best spleen tonification when combined with raw coix seed in the present invention. In addition, astragalus can also discharge pus, promote tissue regeneration, promote diuresis and reduce swelling, and help remove toxins from the skin.

[0018] Rhizoma Cynoglossi is a blood-activating herb that enters the liver and kidney meridians, promotes the flow of qi and blood, and can guide medicine, blood, and fire downward. The Chinese Materia Medica states that it has the effect of "breaking blood and descending", and is effective in treating damp-heat, blood heat, and liver yang hyperactivity. Rhizoma Bletillae belongs to the lung, liver, and stomach meridians, and can astringe and stop bleeding, reduce swelling, and promote tissue regeneration. The Ben Jing states that it "treats carbuncle, malignant ulcer, gangrene, yin injury, dead muscle, evil qi in the stomach, wind and ghost attack, and prickly heat that does not heal."

[0019] Phellodendron chinense is a heat-clearing medicine with the effects of clearing away heat and dampness, purging fire and removing steam, and detoxifying and treating sores. When matched with wild chrysanthemum and Radix Isatidis, its anti-inflammatory and detoxifying effects are better. Among them, Radix Isatidis is bitter and cold, and people with spleen and stomach deficiency and cold should use it with caution. In the present invention, raw Astragalus, stir-fried Atractylodes, etc. can all weaken the bitter and cold gas of Radix Isatidis.

[0020] Verbena has the effects of promoting blood circulation, removing blood stasis, detoxifying, promoting diuresis, relieving jaundice, and stopping malaria, but it should be used with caution by people with weak spleen and stomach. "Bielu" records that it "treats hidden sores in the lower body."

[0021] Peppermint is a wind-heat dispersing medicine, which is mainly used for exogenous wind-heat, headache, sore throat, food stagnation and bloating, mouth sores, toothache, scabies, urticaria, early stage of febrile disease, urticaria pruritus, liver depression and qi stagnation, chest tightness and hypochondria. In addition, peppermint is more pungent than bitter and non-toxic. The present invention takes its fragrant smell and benefits the orifices, and is good at moving the muscles and surfaces. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] Embodiment 1

[0024] A traditional Chinese medicine composition that can turn HPV positive to negative is composed of the following traditional Chinese medicines: 30g of Hedyotis diffusa, 15g of raw coix seed, 10g of stir-fried atractylodes, 10g of phellodendron, 10g of Cyathula officinalis, 10g of raw astragalus, 10g of bletilla striata, 10g of wild chrysanthemum, 10g of isatis root, 10g of verbena and 10g of mint.

[0025] Soak the above Chinese medicinal materials in cold water for 40 minutes, and simmer over low heat from the moment the water boils, i.e., the first decoction is 25 minutes; the second decoction is 20 minutes, and the residue is filtered out to obtain a total of 300 mL of juice.

[0026] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0027] Embodiment 2

[0028] A traditional Chinese medicine composition that can turn HPV positive to negative is composed of the following traditional Chinese medicines: 33g of Hedyotis diffusa, 13g of raw coix seed, 12g of stir-fried atractylodes, 8g of Phellodendron chinense, 12g of Cyathula officinalis, 8g of raw astragalus, 12g of Bletilla striata, 8g of wild chrysanthemum, 12g of Isatis root, 8g of verbena and 12g of mint.

[0029] Soak the above Chinese medicinal materials in cold water for 50 minutes, and simmer for 30 minutes from the time the pot boils; 15 minutes for the second decocting, filter out the residue and take 320 mL of juice in total.

[0030] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0031] Embodiment 3

[0032] A traditional Chinese medicine composition that can turn HPV positive to negative is composed of the following traditional Chinese medicines: 27g of Hedyotis diffusa, 17g of raw coix seed, 8g of stir-fried atractylodes, 12g of phellodendron, 8g of Cyathula officinalis, 12g of raw astragalus, 8g of bletilla striata, 12g of wild chrysanthemum, 8g of isatis root, 12g of verbena and 8g of mint.

[0033] Soak the above Chinese medicinal materials in cold water for 30 minutes, and simmer them over low heat for 20 minutes from the moment the water boils; simmer for 20 minutes for the second time, filter out the residue and take out 290 mL of juice.

[0034] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0035] Embodiment 4

[0036] Prepare water pills that can turn HPV positive to negative according to the following steps:

[0037] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powders below 60 mesh, and mix them according to the following formula;

[0038] The Chinese medicinal powder is composed of the following parts by mass: 30 parts of Hedyotis diffusa, 15 parts of raw coix seeds, 10 parts of stir-fried atractylodes, 10 parts of phellodendron, 10 parts of cyathula, 10 parts of raw astragalus, 10 parts of bletilla striata, 10 parts of wild chrysanthemum, 10 parts of isatis root, 10 parts of verbena and 10 parts of mint.

[0039] S2. Adjust moisture: Add water and stir until it sticks together.

[0040] S3, pilling: the pellets are made by a pilling machine and packaged.

[0041] Embodiment 5

[0042] Prepare water pills that can turn HPV positive to negative according to the following steps:

[0043] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powders below 60 mesh, and mix them according to the following formula;

[0044] The Chinese medicinal powder is composed of the following parts by mass: 33 parts of Hedyotis diffusa, 13 parts of raw coix seeds, 12 parts of stir-fried atractylodes, 8 parts of phellodendron, 12 parts of cyathula, 8 parts of raw astragalus, 12 parts of bletilla striata, 8 parts of wild chrysanthemum, 12 parts of isatis root, 8 parts of verbena and 12 parts of mint.

[0045] S2. Adjust moisture: Add wine and stir until it sticks together.

[0046] S3, pelleting: pelleting by pelleting machine and packaging of finished products

[0047] Embodiment 6

[0048] Prepare water pills that can turn HPV positive to negative according to the following steps:

[0049] S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powders below 60 mesh, and mix them according to the following formula;

[0050] The Chinese medicinal powder is composed of the following parts by mass: 27 parts of Hedyotis diffusa, 17 parts of raw coix seeds, 8 parts of stir-fried atractylodes, 12 parts of phellodendron, 8 parts of cyathula, 12 parts of raw astragalus, 8 parts of bletilla striata, 12 parts of wild chrysanthemum, 8 parts of isatis root, 12 parts of verbena and 8 parts of mint.

[0051] S2. Adjust moisture: Add honey and stir until it sticks together.

[0052] S3, pilling: use a manual pill maker to make pills and package the finished products.

[0053] The effect of the Chinese medicine composition for converting HPV positive to negative provided by the present invention is described below.

[0054] 1. General Information

[0055] A total of 120 low-risk HPV-positive patients were randomly divided into treatment group 1 with 60 cases and control group 1 with 60 cases. A total of 86 high-risk HPV-positive patients were randomly divided into treatment group 2 with 44 cases and control group 2 with 42 cases.

[0056] There were 33 males and 27 females in treatment group 1, with an average age of 34.6 years and an average disease course of 2 years and 3 months; there were 34 males and 26 females in control group 1, with an average age of 33.5 years and an average disease course of 2 years and 2 months.

[0057] There were 25 males and 19 females in treatment group 2, with an average age of 37.2 years and an average disease course of 3 years and 5 months; there were 22 males and 20 females in control group 2, with an average age of 36.8 years and an average disease course of 3 years and 4 months.

[0058] The clinical data of the four groups of patients were statistically processed and showed no significant difference, so they were judged to be comparable. Explanation on the dropout situation of the four groups: All groups completed the clinical trial and there was no dropout record.

[0059] 2. Diagnosis and exclusion criteria

[0060] 2.1 Diagnostic criteria

[0061] In low-risk HPV-positive patients, 3 or more low-risk (including medium-risk) HPV virus DNA tests are positive;

[0062] In patients who are positive for high-risk HPV, 4 or more items in the high-risk HPV virus DNA test are positive.

[0063] 2.2 Efficacy evaluation and judgment criteria

[0064] DNA tests for various HPV virus types turned negative;

[0065] No recurrence within 1 year after turning negative.

[0066] Specific efficacy criteria:

[0067] (1) Clinical cure: DNA tests for all HPV virus types turn negative, and there is no recurrence within 1 year after turning negative.

[0068] (2) Significantly effective: DNA tests for all HPV virus types turned negative, but one or more recurrences occurred within one year after turning negative.

[0069] (3) Effective: DNA tests for all HPV virus types have not turned negative, but the negative types account for 60% or more of the original infection types, and no new infection types have appeared.

[0070] (4) Ineffective: DNA tests for all HPV virus types did not turn negative or any new infection type appeared.

[0071] 3. Treatment methods

[0072] Group 1 and Group 2 were treated with the Chinese medicine composition described in Example 1 of the present invention, about 150 mL each time, twice a day, half an hour before breakfast and dinner. The patients washed the affected area with clean water every day to ensure that the affected area was clean and avoid cross infection.

[0073] For control groups 1 and 2, recombinant interferon a2b was applied externally and spleen aminopeptide freeze-dried powder was taken orally. Patients needed to keep the affected area clean to avoid cross infection.

[0074] The treatment course for treatment group 1 and treatment group 2 was four weeks, and the treatment course for control group 1 and control group 2 was two weeks. The treatment effects of the four groups were statistically analyzed after six courses of treatment, and the negative conversion was followed up for one year.

[0075] See Table 1 for specific statistical and analysis results.

[0076] Total effective rate = (number of clinically cured cases + number of markedly effective cases + number of effective cases) ÷ number of cases × 100%.

[0077] Using t-test and X 2 The test results showed that *P<0.05, indicating that the statistical results in Table 1 are significant.

[0078] Table 1: Comparison of efficacy after treatment

[0079]

[0080]

[0081] As can be seen from the results in Table 1, the Chinese medicine composition of the present invention has significant curative effect in the treatment of HPV infection, whether for high-risk or low-risk patients, especially for high-risk patients. The total effective rate is much higher than that of the control group. More importantly, the clinical cure rate of the treatment group using the present invention is higher, wherein the clinical cure rate of treatment group 1 reaches 38.2%, and the clinical cure rate of control group 1 reaches 35.0%; the clinical cure rate of treatment group 2 reaches 30.9%, and the clinical cure rate of control group 2 reaches 25.0%, and the treatment groups are higher than the corresponding control groups. From the research results, it can be seen that in the low-risk test group, the advantage of the treatment group is relatively low, which may be because the low-risk type of the disease site is mostly distributed on the body surface, and the topical interferon can directly reach the affected area and eliminate the virus, but the high-risk type often develops in the body such as the cervix, urethra, and rectum, and interferon cannot play a good role.

[0082] In addition, the patients in the control group of the present invention took spleen aminopeptide freeze-dried powder, which can enhance cellular immunity. Although the treatment course of the control group was short, it was more likely to relapse. This may be due to the fact that spleen aminopeptide freeze-dried powder and other Western medicine products that enhance immunity have a certain timeliness. Once the administration is stopped, the immunity will soon decrease.

Claims

1. A Chinese medicine composition capable of converting HPV positive to negative, characterized in that: The traditional Chinese medicine composition is made of 27 to 33 parts of oldenlandia diffusa, 13 to 17 parts of raw coix seeds, 8 to 12 parts of stir-fried atractylodes, 8 to 12 parts of phellodendron, 8 to 12 parts of cyathula, 8 to 12 parts of raw astragalus, 8 to 12 parts of bletilla striata, 8 to 12 parts of wild chrysanthemum, 8 to 12 parts of isatis root, 8 to 12 parts of verbena and 8 to 12 parts of mint, in parts by weight.

2. A Chinese medicine composition capable of converting HPV positive to negative according to claim 1, characterized in that: The Chinese medicine composition is prepared by weight from 30 parts of oldenlandia diffusa, 15 parts of raw coix seeds, 10 parts of stir-fried atractylodes, 10 parts of phellodendron, 10 parts of cyathula, 10 parts of raw astragalus, 10 parts of bletilla striata, 10 parts of wild chrysanthemum, 10 parts of isatis root, 10 parts of verbena and 10 parts of mint.

3. The Chinese medicine composition capable of converting HPV positive to negative according to any one of claims 1 or 2, characterized in that: Soak the Chinese medicine composition in cold water for 30 to 50 minutes, simmer for 20 to 30 minutes on a low fire from the time the pot boils, simmer for 15 to 25 minutes, filter out the residue to obtain a decoction, and take it orally twice a day, morning and evening.

4. A Chinese medicine preparation capable of converting HPV positive to negative, using the Chinese medicine composition according to any one of claims 1 to 3 as a Chinese medicinal material, characterized in that: The Chinese medicine preparation is a water pill, and the specific preparation steps include: S1. Material selection and formulation: Select Chinese herbal medicines that comply with the provisions of the Chinese Pharmacopoeia, wash and dry them, crush them into fine powder, and mix them according to the formula ratio; S2. Adjust moisture: add water, wine or honey, and stir until it sticks together; S3. Pilling: Make pills using a pilling machine or a manual pilling machine, and package the finished products.

Images