Traditional Chinese medicine ointment preparation for treating angina pectoris and preparation method thereof

Abstract

The invention relates to the technical field of biological medicine, and discloses a traditional Chinese medicine ointment preparation for treating angina pectoris and a preparation method thereof.The traditional Chinese medicine ointment preparation is prepared from, by weight, 15 parts of rhizoma galangae, 15 parts of rhizoma corydalis, 15 parts of rhizoma curcumae, 5 parts of herba asari, 1 part of borneol and the balance auxiliary materials, and the auxiliary materials in the embodiment are vaseline. The preparation method of the traditional Chinese medicinal ointment preparation comprises the following steps: S1, preparing medicinal materials and tools: preparing the medicinal materials and the tools according to the prescription dosage, wherein the tools comprise a grinder, a 100-mesh screen, a weighing tool, a stirrer, a sterile glass bottle and a sealing cover; s2, crushing the medicinal materials: grinding the galangal, the corydalis tuber, the curcuma zedoary, the asarum and the borneol into fine powder by using a grinder; s3, sieving: sieving the fine powder in the S2 one by one by using a 100-mesh sieve; s4, mixing the medicine powder and the auxiliary materials; and S5, bottling and sealing. The traditional Chinese medicine composition has the characteristics of high active ingredient content, simple preparation process and good repeatability, and is an innovation of medicines for treating chronic stable labor type angina pectoris.

Description

Technical Field

[0001] The invention relates to the technical field of biomedicine, and in particular to a traditional Chinese medicine ointment for treating angina pectoris and a preparation method thereof. Background Art

[0002] Chronic stable exertional angina pectoris is a condition characterized by acute and transient myocardial ischemia and hypoxia caused by increased myocardial load on the basis of fixed severe stenosis of the coronary arteries. The clinical manifestations include chest pain and chest tightness during exertion, which seriously affect the patient's quality of life. Drug therapy is the basis for the treatment of chronic stable exertional angina pectoris, but drug resistance and adverse reactions limit the patient's compliance. Coronary revascularization is an effective method for the treatment of coronary heart disease, which can quickly improve myocardial blood supply and relieve symptoms. However, the value of revascularization therapy in improving chronic stable exertional angina pectoris and prognosis is still controversial, and problems such as postoperative restenosis limit the clinical benefits of patients. Further exploration of new treatment methods is still needed to better improve the prognosis and quality of life of patients. In recent years, traditional Chinese medicine has shown unique advantages and potential in the treatment of cardiovascular diseases, which can reduce the frequency of angina pectoris and relieve pain. The exploration of a treatment model combining traditional Chinese and Western medicine has received increasing attention.

[0003] Chronic stable exertional angina pectoris belongs to the category of chest pain in traditional Chinese medicine. Its pathogenesis is always deficiency of the root and excess of the superficial. It is based on deficiency of qi, blood, yin and yang, and is marked by qi stagnation, blood stasis, and phlegm turbidity. Heart meridian obstruction is its key pathogenesis. The present invention selects Corydalis yanhusuo to promote blood circulation and remove blood stasis, promote qi circulation and relieve pain; Curcuma zedoaria promotes qi circulation and removes blood stasis, eliminates accumulation and relieves pain. The combination of the two medicines lays the foundation for the prescription to promote blood circulation, promote qi circulation and relieve pain. Asarum is warm in nature and pungent in taste, good at wandering, and helps to promote blood circulation and dredge collaterals; Alpinia galanga is good at dispersing cold pathogens and relieving pain; borneol can be used to enhance the analgesic effect, neutralize the warm nature of the former medicine, and can also lead the medicines into the heart meridian to enhance the permeability of the medicine to the skin. The five medicines are used together to promote blood circulation and remove blood stasis, promote qi circulation and relieve pain.

[0004] Paste is one of the five major drug dosage forms in traditional Chinese medicine. It is simple and convenient to make and use. Paste can directly act on the lesion site, reduce systemic side effects and increase safety. Chinese medicine paste massage technology is an improved technology that combines paste and massage. It uses Chinese medicine paste as a medium, combined with meridian warming method and massage method to act on the back Zhiyang acupoint, which can stimulate yang energy, unclog meridians, and promote the circulation of qi and blood. The physical and chemical stimulation of the local skin by paste massage technology can also promote drug absorption, enhance the drug's effect of promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and improve the patient's clinical symptoms.

[0005] In summary, the purpose of the present invention is to overcome the shortcomings of the current treatment of chronic stable exertional angina pectoris, to use the Chinese medicine paste massage method to act on the Zhiyang acupoint, to give full play to the synergistic effect of Chinese medicine and meridians, to improve the clinical symptoms of patients, and to improve the quality of life. In addition, the present invention has the advantages of "simple, convenient, effective, cheap and safe", and has certain clinical promotion value. Summary of the invention

[0006] In view of the above-mentioned deficiencies in the prior art, the present invention provides a Chinese medicine ointment preparation for treating angina pectoris and a preparation method thereof to maintain the patient's angina pectoris in a stable state, improve the quality of life and prognosis, and at the same time ensure the safety of treatment and the compliance of patients.

[0007] In order to achieve the above-mentioned invention object, the technical scheme adopted by the present invention is: a Chinese medicine ointment for treating angina pectoris and a preparation method thereof, which is prepared from the following raw materials in parts by weight: 15 parts of galangal, 15 parts of yanhusuo, 15 parts of zedoaria, 5 parts of asarum, 1 part of borneol, and the remainder of auxiliary materials; the preparation method of the Chinese medicine ointment comprises the following steps:

[0008] S1, prepare medicinal materials and tools: prepare medicinal materials and tools according to the above prescription amount, the tools include grinder, 100 mesh sieve, weighing tool, stirrer, sterile glass bottle and sealing cap;

[0009] S2, crushing medicinal materials: using a grinder to grind galangal, yanhusuo, zedoaria, asarum and borneol into fine powder;

[0010] S3, sieving: sieving the fine powders in S2 one by one with a 100-mesh sieve to obtain drug powder;

[0011] S4, mixing the drug powder and the excipients: mixing the drug powder and the excipients in a prescription ratio of 5:1, and stirring them evenly with a stirrer until a paste is formed to obtain a Chinese medicine ointment;

[0012] S5, bottling and sealing: put the Chinese medicine ointment preparation in S4 into a sterile glass bottle and seal it with a sealing cap.

[0013] The beneficial effects of the present invention are as follows: in terms of the selection of medicinal materials, Corydalis yanhusuo can promote blood circulation and dissipate blood stasis, promote qi circulation and relieve pain; Curcuma zedoaria can promote qi circulation and dissolve blood stasis, eliminate stagnation and relieve pain, and the combination of the two medicines lays the foundation for the prescription to promote blood circulation, promote qi circulation and relieve pain. Asarum is warm in nature and pungent in taste, good at moving around, and helps to promote blood circulation and dredge collaterals; Alpinia galanga is good at dispersing cold pathogens and relieving pain; and the addition of borneol can not only enhance the analgesic effect, but also neutralize the warm nature of the former medicine. The reasonable configuration of these medicinal materials enables the Chinese medicine ointment preparation to play a multi-faceted therapeutic role for the disease of angina pectoris, which can not only relieve pain, but also improve local blood circulation, thereby achieving the effect of treating both the symptoms and the root causes.

[0014] In terms of preparation technology, the present invention adopts multiple steps such as grinding, sieving, mixing, and stirring to ensure that the medicinal materials are fully refined and evenly mixed. Through grinding and sieving, a fine and uniform medicinal powder can be obtained, which is conducive to improving the utilization rate of the medicinal materials and the stability of the preparation. Mixing and stirring allow the medicinal powder and the auxiliary materials to be fully integrated to form a uniform paste preparation, which is not only convenient for subsequent use, but also helps to evenly release the medicinal effect.

[0015] Furthermore, the auxiliary material of the above-mentioned Chinese medicine ointment preparation for treating angina pectoris and its preparation method is vaseline.

[0016] The beneficial effects of adopting the above further scheme are: Vaseline has good ductility and adhesion, so that the Chinese medicine ointment preparation can better fit the skin when used, and evenly cover the painful area of ​​the angina pectoris patient, which not only helps to fully absorb and exert the efficacy of the medicine, but also reduces the waste and loss of the medicine during use. At the same time, the ductility of vaseline also makes the preparation smoother when used, reducing the difficulty and discomfort of the patient's application.

[0017] As an oily substance, Vaseline can help the active ingredients in the powder in traditional Chinese medicine ointments to better penetrate the skin surface and enter the deep tissues, thereby exerting a therapeutic effect. It helps to improve the bioavailability and therapeutic effect of the drug, allowing traditional Chinese medicine ointments to relieve the symptoms of patients with angina pectoris more quickly.

[0018] Furthermore, the above-mentioned Chinese medicine ointment preparation for treating angina pectoris and its preparation method, the sieve is a 100-mesh sieve.

[0019] The beneficial effects of the present invention are: the Chinese medicine ointment preparation can optimize the treatment plan of the disease, reduce the medical burden of the patient, and save medical resources. At the same time, the Chinese medicine ointment preparation also has the characteristics of high active ingredient content, simple preparation process, and good repeatability. It is an innovation in the treatment of chronic stable exertional angina pectoris and has huge economic and social benefits. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The present invention is a flow chart of the preparation method of the Chinese medicine ointment preparation. DETAILED DESCRIPTION

[0021] The specific implementation modes of the present invention are described below so that those skilled in the art can understand the present invention. However, it should be clear that the present invention is not limited to the scope of the specific implementation modes. For those of ordinary skill in the art, as long as various changes are within the spirit and scope of the present invention as defined and determined by the attached claims, these changes are obvious, and all inventions and creations utilizing the concept of the present invention are protected.

[0022] like Figure 1As shown, this embodiment provides a Chinese medicine ointment preparation for treating angina pectoris and a preparation method thereof, and demonstrates its application effect through clinical examples. The Chinese medicine ointment preparation is made from traditional Chinese medicinal materials and processed by modern technology, aiming to provide patients with a safe and effective treatment option.

[0023] The raw materials of the present Chinese medicine ointment preparation are in parts by weight, including the following ingredients: 15 parts of galangal, 15 parts of yanhusuo, 15 parts of zedoaria, 5 parts of asarum, 1 part of borneol, and the remainder of auxiliary materials. In the present embodiment, the selected auxiliary material is vaseline, which has good stability and compatibility, and can ensure the stability of the preparation and the efficacy of the medicine.

[0024] The preparation method of the Chinese medicine ointment preparation comprises the following steps:

[0025] S1. Prepare medicinal materials and tools: Prepare medicinal materials and tools according to the above prescription amount. The tools include grinder, 100-mesh sieve, weighing tool, stirrer, sterile glass bottle and sealing cap. Make sure all tools and containers are clean and sterile to avoid introducing impurities during the preparation process.

[0026] S2, crushing medicinal materials: put galangal, yanhusuo, zedoaria, asarum and borneol into a grinder and grind them respectively until the medicinal materials are crushed into fine powder. This step is to increase the surface area of ​​the medicinal materials, which is conducive to the subsequent release and absorption of the medicinal effect;

[0027] S3, sieving: sieve the fine powder in S2 one by one with a 100-mesh sieve to remove coarse particles and impurities to obtain uniform and fine powder;

[0028] S4, mixing the drug powder and excipients: according to the prescription ratio of 5:1 of drug powder to excipients, put the drug powder and vaseline into a blender and mix and stir them thoroughly. During the stirring process, control the stirring speed and time to ensure that the drug powder and excipients can be evenly mixed and form a stable paste preparation, which is a Chinese medicine ointment preparation;

[0029] S5, bottling and sealing: put the Chinese medicine paste preparation stirred evenly in S4 into the pre-prepared sterile glass bottle and seal it tightly with a sealing cap to ensure that the preparation can maintain good sealing and stability during storage and use.

[0030] This example adopts a single-arm clinical study design. The inclusion criteria for the study subjects include meeting the diagnostic criteria for chronic stable exertional angina pectoris, experiencing tingling or dull pain in the past month, and even spreading to the shoulder and back pain, and the patients are willing to accept the treatment of this study. Exclusion criteria include patients with severe skin diseases or drug allergies, and patients who are unwilling to accept the treatment of this study.

[0031] During the treatment, the patient first lies flat, and the doctor accurately finds the patient's Zhiyang acupoint according to the acupoint positioning method and cleans the skin around the acupoint. Then, the doctor evenly applies the pre-prepared Chinese medicine ointment to the Zhiyang acupoint to ensure that the preparation can fully cover the acupoint and closely contact with the skin.

[0032] The doctor then uses a moxibustion therapy device to continuously apply heat and massage to the Zhiyang acupoints that have been smeared with the Chinese medicine ointment. The temperature and duration of the hot compress are adjusted according to the patient's tolerance and specific condition to ensure the safety and effectiveness of the treatment. The treatment is performed 2-3 times a week, and each treatment lasts 20 minutes.

[0033] In order to evaluate the therapeutic effect, the Seattle Angina Scale was used as an observation index. The patients received Chinese medicine ointment massage treatment once every 2 days, and filled in the scale before and after 6 treatments. The collected data were statistically analyzed by SPSS25.0. All measurement data were expressed as mean ± standard deviation. For measurement data that conformed to the normal distribution, the paired sample T test was used to compare the data before and after treatment. For measurement data that did not conform to the normal distribution, the Wilcoxon signed rank test was used to compare the data before and after treatment. P < 0.05 was set as statistically significant.

[0034] A total of 9 patients with chronic stable exertional angina pectoris were included in this study. The paired sample T test was used to compare and analyze the Seattle Angina Scale scores of patients before and after treatment with Chinese medicine ointment. The results showed that the AF score of the patients after treatment was higher than that before treatment, and the difference was statistically significant (P < 0.05), indicating that the frequency of angina attacks in patients was controlled after treatment with Chinese medicine ointment. At the same time, the results of this study showed that the degree of limitation of physical activity, stable state of angina pectoris, satisfaction with treatment and degree of disease cognition of patients after treatment with Chinese medicine ointment were improved, and the difference was not statistically significant (P > 0.05). The comparison of Seattle Angina Scale scores of patients before and after treatment is shown in Table 1.

[0035] Table 1: Comparison of Seattle Angina Scale scores before and after treatment

[0036]

[0037]

[0038] Note: * P < 0.05 indicates statistically significant differences.

[0039] The results showed that Chinese medicine ointment massage can effectively improve chronic stable exertional angina, especially in controlling the frequency of angina attacks. In addition, this method also showed the potential to improve the quality of life of patients in many aspects, including reducing physical activity limitations, improving the stability of angina, enhancing treatment satisfaction and improving disease cognition. Chinese medicine ointment massage provides a treatment option with good application prospects for patients with chronic stable exertional angina.

Claims

1. A Chinese medicine ointment for treating angina pectoris and a preparation method thereof, characterized in that: The preparation method of the Chinese medicine ointment preparation is based on parts by weight: 15 parts of galangal, 15 parts of yanhusuo, 15 parts of zedoaria, 5 parts of asarum, 1 part of borneol, and the remainder of auxiliary materials. The preparation method of the Chinese medicine ointment preparation comprises the following steps: S1, preparing medicinal materials and tools: preparing medicinal materials and tools according to the above prescription amount, the tools including a grinder, a sieve, a weighing tool, a stirrer, a sterile glass bottle and a sealing cap; S2, crushing medicinal materials: using a grinder to grind galangal, yanhusuo, zedoaria, asarum and borneol into fine powder; S3, sieving: sieving the fine powders in S2 one by one with a sieve to obtain medicinal powder; S4, mixing the drug powder and the excipients: mixing the drug powder and the excipients in a prescription ratio of 5:1, and stirring them evenly with a stirrer until a paste is formed to obtain a Chinese medicine ointment; S5, bottling and sealing: put the Chinese medicine ointment preparation in S4 into a sterile glass bottle and seal it with a sealing cap.

2. The Chinese medicine ointment for treating angina pectoris and its preparation method according to claim 1, characterized in that: The auxiliary material is vaseline.

3. The Chinese medicine ointment for treating angina pectoris and its preparation method according to claim 1, characterized in that: The sieve is a 100-mesh sieve.

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