A dressing that can reduce scar formation and its preparation method

Abstract

This application discloses a dressing that can reduce scar formation and its preparation method, specifically including the following steps: preparing an aqueous solution of polyethylene oxide (PEG) A; dissolving polyethylene glycol and glycerin in water to prepare a solution, then adding cyclodextrin to obtain a mixed aqueous solution B; stirring PEG A and mixed aqueous solution B in a certain proportion to obtain a solution C; immersing a non-woven fabric in solution C, drying it, and then taking a membrane to obtain membrane A; taking the dried membrane and immersing it in a tannic acid ethanol / water mixed solution; drying it after immersion, stretching it after drying, and then fumigating and crosslinking it to obtain membrane B; immersing membrane B in an anhydrous ethanol solution of polyvinylpyrrolidone and drying it to obtain a shrinkable layer; and combining an adhesive base, a shrinkable layer, an absorbent layer, and a release paper to obtain the aforementioned dressing that can reduce scar formation. This invention provides a dressing that can reduce scar formation, which can immediately cause skin contraction upon contact with wound exudate, thus reducing scar formation.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, and in particular to a dressing that can reduce scarring. Background Technology

[0002] After surgery, the skin around the wound needs to be sutured and a dressing applied to protect the wound. Scarring occurs during the healing process, affecting appearance. Common methods to reduce scarring include using medical elastic bandages with traction and applying regular medical tape to the wound. However, medical elastic bandages do not absorb wound exudate and are more suitable for wounds that are nearly healed; regular tape has weak adhesion and limited effectiveness. They are not very effective for postoperative wounds or ordinary wounds. Summary of the Invention

[0003] The purpose of this invention is to provide a dressing that can reduce scar formation and a method for preparing the same, in order to overcome the shortcomings of the prior art.

[0004] To achieve the above objectives, the present invention provides the following technical solution:

[0005] This application discloses a method for preparing a dressing that can reduce scar formation, specifically including the following steps:

[0006] S1. Prepare a 2%~4% polyethylene oxide aqueous solution A;

[0007] S2. Dissolve polyethylene glycol and glycerin in water to prepare a solution with a concentration of 2% to 4%, then add cyclodextrin and mix and stir to obtain a mixed aqueous solution B;

[0008] S3. Mix the polyethylene oxide aqueous solution A from step S1 and the mixed aqueous solution B from step S2 in a certain proportion to obtain solution C.

[0009] S4. A nonwoven fabric with a spandex content greater than 10% is immersed in solution C, dried, and the resulting membrane is membrane A; the ratio of the area of ​​the nonwoven fabric to the area of ​​the mixed solution C is 1 cm². 2 0.2~2g;

[0010] S5. Take the membrane dried in step S4 and immerse it in a tannic acid-ethanol / water mixed solution; after immersion, dry it at 40~60℃. After drying, stretch and crosslink it at 40~60℃ to obtain membrane B.

[0011] S6. Immerse the membrane B from step S5 in an anhydrous ethanol solution of polyvinylpyrrolidone and dry it at 40℃~60℃ to obtain a shrinkable layer.

[0012] S7. The adhesive base, shrinkable layer, absorbent layer and release paper are combined to obtain the aforementioned dressing that can reduce scar formation.

[0013] Preferably, the molecular weight of the polyethylene oxide in step S1 is 500,000 to 2,000,000; and the molecular weight of the polyethylene glycol in step S2 is 800 to 2,000.

[0014] Preferably, in step S2, the mass of polyethylene glycol and glycerol are equal; the mass of cyclodextrin is 10 times that of polyethylene oxide.

[0015] Preferably, the mixing temperature in step S2 is 35~65℃ and the time is 10~30min.

[0016] Preferably, the ratio of polyethylene oxide aqueous solution A to mixed aqueous solution B in step S3 is 1:3 to 1:5.

[0017] Preferably, in step S4, the nonwoven fabric is immersed in solution C under a stretched state, wherein the stretch ratio is 2~3; and the drying temperature is 40~60℃.

[0018] Preferably, in step S5, the stretching ratio is 1 to 2; the crosslinking method is formaldehyde fumigation crosslinking, the time is 1 hour, and the formaldehyde concentration is 4%.

[0019] Preferably, in step S5, the tannic acid concentration is 2-10%, the solution is a 50-70% ethanol aqueous solution, the soaking temperature is room temperature, and the soaking time is 25-35 minutes.

[0020] Preferably, in step S6, the concentration of polyvinylpyrrolidone is 2% to 4%, the solvent is anhydrous ethanol, the soaking temperature is room temperature, and the soaking time is 25 to 35 minutes.

[0021] The present invention also discloses a dressing that can reduce scar formation, which is prepared by the method described above for preparing a dressing that can reduce scar formation;

[0022] The dressing shrinks upon contact with water / exudate, with a shrinkage rate >70%.

[0023] The product structure consists of an adhesive base, a shrinkable layer D, an absorbent layer, and a release paper;

[0024] The dressing can shrink the skin near the wound, reducing scarring.

[0025] The beneficial effects of this invention are:

[0026] 1. The present invention provides a dressing that can reduce scar formation. The dressing can immediately cause the skin to contract upon contact with wound exudate, thereby reducing scar formation.

[0027] 2. The shrinkable layer of the dressing of the present invention is adhesive and can be tightly adhered to the absorbent layer and the adhesive layer, thus preventing the layers from falling off and not shrinking during use;

[0028] 3. The shrinkable layer of the dressing of the present invention is reinforced with a polymer, which allows it to shrink simultaneously with the tape, thus avoiding the situation where it cannot carry other parts.

[0029] 4. The elastic nonwoven fabric of the shrinkable layer of the present invention absorbs water simultaneously with the absorbent layer, which can make the absorbent layer thinner, and make it easier to shrink while meeting the water absorption ratio.

[0030] 5. The presence of tannic acid in the dressing of the present invention gives the product excellent bactericidal properties.

[0031] The features and advantages of the present invention will be described in detail through embodiments and in conjunction with the accompanying drawings. Attached Figure Description

[0032] Figure 1 Example 1: Schematic diagram of contraction;

[0033] Figure 2 A diagram comparing the healing rates of the products;

[0034] Figure 3 This is a schematic diagram of sample preparation for adhesive strength testing; Detailed Implementation

[0035] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. However, it should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of the invention. Furthermore, descriptions of well-known structures and technologies are omitted in the following description to avoid unnecessarily obscuring the concept of the invention.

[0036] Example 1:

[0037] S1: Dissolve 1g of polyethylene oxide 500000 in 49g of water at 60℃ to obtain a 2% polyethylene oxide aqueous solution A;

[0038] S2: Dissolve 1.5g PEG800 and 1.5g glycerol in 147g water to obtain a 2% solution. Dissolve 10g cyclodextrin in the above solution at 60℃ and stir for 30min to obtain mixed aqueous solution B;

[0039] S3: Take 10g of polyethylene oxide aqueous solution A and 30g of mixed aqueous solution B, mix them evenly to obtain solution C;

[0040] S4: Take a nonwoven fabric with 11% spandex content and stretch it twice (using a tensile testing machine, area 10cm²). 2 Add 2g of mixed solution C, spread evenly, and dry at 40℃ to obtain membrane A.

[0041] S5: Dissolve 2g of tannic acid in 98g of 50% ethanol / water solution. Take membrane A, dried in step S4, immerse it in the solution for 30min, and then dry it at 40℃. Stretch the dried membrane by 1 time at 40℃ (using a tensile testing machine), and then fumigate it in 4% formaldehyde solution for 1h to obtain membrane B;

[0042] S6: Immerse membrane B from step S5 in an anhydrous ethanol solution of 2% polyvinylpyrrolidone for 30 min, and dry at 40°C; to obtain a shrinkable layer.

[0043] S7: The adhesive base, shrinkable layer, absorbent layer and release paper are laminated in sequence to obtain the final product;

[0044] The adhesive base is made of tape, and the absorbent layer is made of ordinary absorbent cotton.

[0045] Apply the product to moist skin and observe the shrinkage. Figure 1 );

[0046] Example 2:

[0047] S1: Dissolve 2g of polyethylene oxide 2000000 in 48g of water at 60℃ to obtain a 4% polyethylene oxide aqueous solution A;

[0048] S2: Dissolve 3g of PEG 2000 and 3g of glycerol in 144g of water to obtain a 4% solution. Dissolve 20g of cyclodextrin in the above solution at 60℃ and stir for 30min to obtain mixed aqueous solution B;

[0049] S3: Take 10g of solution A and 50g of solution B, mix them thoroughly to obtain solution C;

[0050] S4: Take a nonwoven fabric with 11% spandex content and stretch it 3 times (using a tensile testing machine, area 10cm²). 2 Add 20g of mixed solution C, spread evenly, and dry at 60℃ to obtain membrane A.

[0051] S5: Dissolve 10g of tannic acid in 90g of 75% ethanol / water solution. Take membrane A, dried in step S4, immerse it in the solution for 30min, and then dry it at 60℃. Stretch the dried membrane twice its original size at 60℃ (using a tensile testing machine), and then fumigate it in 4% formaldehyde solution for 1h to obtain membrane B;

[0052] S6: Immerse the membrane from step S5 in an anhydrous ethanol solution of 4% polyvinylpyrrolidone for 30 min, and dry at 60°C; to obtain a shrinkable layer.

[0053] S7: The adhesive base, shrinkable layer, absorbent layer and release paper are laminated in sequence to obtain the final product;

[0054] Example 3:

[0055] S1: Dissolve 1.5g of polyethylene oxide 1000000 in 48.5g of water at 60℃ to obtain a 3% polyethylene oxide aqueous solution A;

[0056] S2: Dissolve 2.25g of PEG 1000 and 2.25g of glycerol in 145.5g of water to obtain a 3% solution. Dissolve 15g of cyclodextrin in the above solution at 60℃ and stir for 30min to obtain mixed aqueous solution B;

[0057] S3: Take 10g of polyethylene oxide solution A and 40g of mixed aqueous solution, mix them thoroughly to obtain solution C;

[0058] S4: Take a nonwoven fabric with 11% spandex content and stretch it 2.5 times (using a tensile testing machine, area 10cm²). 2 Add 10g of mixed solution C, spread evenly, and dry at 50℃ to obtain membrane A.

[0059] S5: Dissolve 6g of tannic acid in 94g of 65% ethanol / water solution. Take membrane A, dried in step S4, immerse it in the solution for 30min, and then dry it at 50℃. Stretch the dried membrane 1.5 times at 50℃ (using a tensile testing machine) and then fumigate it in 4% formaldehyde solution for 1h to obtain membrane B;

[0060] S6: Immerse membrane B from step S5 in an anhydrous ethanol solution of 3% polyvinylpyrrolidone for 30 min and dry at 60°C to obtain a shrinkable layer;

[0061] S7: The adhesive base, shrinkable layer, absorbent layer and release paper are laminated in sequence to obtain the final product;

[0062] Comparative Example 1:

[0063] The only difference between this comparative example and Example 1 is that in step S1, 0.5g of polyethylene oxide 500000 is dissolved in 49.5g of water at 60°C to obtain a 1% polyethylene oxide aqueous solution A.

[0064] Comparative Example 2:

[0065] The only difference between this comparative example and Example 1 is that in step S1, 2.5g of polyethylene oxide 500000 is dissolved in 47.5g of water at 60°C to obtain a 5% polyethylene oxide aqueous solution A.

[0066] Comparative Example 3:

[0067] The only difference between this comparative example and Example 1 is that in step S1, 1g of polyethylene oxide 100000 is dissolved in 49g of water at 60°C to obtain a 2% polyethylene oxide aqueous solution A.

[0068] Comparative Example 4:

[0069] The only difference between this comparative example and Example 1 is that in step S1, 1g of polyethylene oxide 3000000 is dissolved in 49g of water at 60°C to obtain a 2% polyethylene oxide aqueous solution A.

[0070] Comparative Example 5:

[0071] The only difference between this comparative example and Example 1 is that in step S2, 0.75g of PEG 2000 and 0.75g of glycerol are dissolved in 148.5g of water to obtain a 1% solution, and 20g of cyclodextrin is dissolved in the above solution at 60°C. The mixture is stirred for 30 minutes to obtain a mixed aqueous solution B.

[0072] Comparative Example 6:

[0073] The only difference between this comparative example and Example 1 is that in step S2, 3.75g of PEG 2000 and 3.75g of glycerol are dissolved in 142.5g of water to obtain a 5% solution, and 20g of cyclodextrin is dissolved in the above solution at 60°C. The mixture is stirred for 30 minutes to obtain a mixed aqueous solution B.

[0074] Comparative Example 7:

[0075] The only difference between this comparative example and Example 1 is that in step S2, 1.5g of PEG 200 and 1.5g of glycerol are dissolved in 147g of water to obtain a 2% solution, and 10g of cyclodextrin is dissolved in the above solution at 60°C. The mixture is stirred for 30 minutes to obtain a mixed aqueous solution B.

[0076] Comparative Example 8:

[0077] The only difference between this comparative example and Example 1 is that in step S3, 20g of polyethylene oxide aqueous solution A and 20g of mixed aqueous solution B are taken, mixed and stirred evenly to obtain solution C.

[0078] Comparative Example 9:

[0079] The only difference between this comparative example and Example 1 is that in step S3, 5g of polyethylene oxide aqueous solution A and 35g of mixed aqueous solution B are mixed and stirred evenly to obtain solution C.

[0080] Comparative Example 10:

[0081] The only difference between this comparative example and Example 1 is that step S4 involves taking a nonwoven fabric with an spandex content of 11% and stretching it by 1 time (with an area of ​​10 cm²). 2 Add 2g of mixed solution C, spread evenly, and dry at 40℃;

[0082] Comparative Example 11:

[0083] The only difference between this comparative example and Example 1 is that step S4 involves taking a nonwoven fabric with an spandex content of 11% and stretching it 5 times (with an area of ​​10 cm²). 2 Add 2g of mixed solution C, spread evenly, and dry at 40℃ to obtain membrane A;

[0084] Comparative Example 12:

[0085] The only difference between this comparative example and Example 1 is that step S4 involves taking a nonwoven fabric with an spandex content of 11% and stretching it 5 times (with an area of ​​10 cm²). 2 Add 1g of mixed solution C, spread evenly, and dry at 40℃ to obtain membrane A;

[0086] Comparative Example 13:

[0087] The only difference between this comparative example and Example 1 is that step S4 involves taking a nonwoven fabric with an spandex content of 11% and stretching it 5 times (with an area of ​​10 cm²). 2 Add 25g of mixed solution C, spread evenly, and dry at 40℃ to obtain membrane A;

[0088] Comparative Example 14:

[0089] The only difference between this comparative example and Example 1 is that: in step S5, 2g of tannic acid is dissolved in 98g of 50% ethanol / water solution, and the membrane A dried in step S4 is soaked in it for 30min and then dried at 40°C. The dried membrane is stretched 0.5 times at 40°C and then fumigated in 4% formaldehyde solution for 1h to obtain membrane B.

[0090] Comparative Example 15:

[0091] The only difference between this comparative example and Example 1 is that: in step S5, 2g of tannic acid is dissolved in 98g of 50% ethanol / water solution, and the membrane A dried in step S4 is soaked in it for 30min and then dried at 40°C. The dried membrane is stretched 3 times at 40°C and then fumigated in 4% formaldehyde solution for 1h to obtain membrane B.

[0092] Comparative Example 16:

[0093] The only difference between this comparative example and Example 1 is that: in step S5, 1g of tannic acid is dissolved in 99g of 50% ethanol / water solution, the membrane dried in step S4 is taken, soaked in it for 30min and then dried at 40℃, the dried membrane is stretched by 1 times at 40℃ and then fumigated in 4% formaldehyde solution for 1h to obtain membrane B.

[0094] Comparative Example 17:

[0095] The only difference between this comparative example and Example 1 is that: in step S5, 15g of tannic acid is dissolved in 85g of 50% ethanol / water solution, and the membrane A dried in step S4 is soaked in it for 30min and then dried at 40°C. The dried membrane is stretched by 1 time at 40°C and then fumigated in 4% formaldehyde solution for 1h to obtain membrane B.

[0096] Comparative Example 18:

[0097] The only difference between this comparative example and Example 1 is that: in step S5, 2g of tannic acid is dissolved in 98g of 40% ethanol / water solution, and the membrane A dried in step S4 is soaked in it for 30min and then dried at 40°C. The dried membrane is stretched by 1 times at 40°C and then fumigated in 4% formaldehyde solution for 1h to obtain membrane B.

[0098] Comparative Example 19:

[0099] The only difference between this comparative example and Example 1 is that: in step S5, 2g of tannic acid is dissolved in 98g of 80% ethanol / water solution, and the membrane A dried in step S4 is soaked in it for 30min and then dried at 40°C. The dried membrane is stretched by 1 times at 40°C and then fumigated in 4% formaldehyde solution for 1h to obtain membrane B.

[0100] Comparative Example 20:

[0101] The only difference between this comparative example and Example 1 is that: in step S6, the membrane B after step S5 is immersed in an anhydrous ethanol solution of 1% polyvinylpyrrolidone for 30 minutes and then dried at 40°C.

[0102] Comparative Example 21:

[0103] The only difference between this comparative example and Example 1 is that: in step S5, 2g of tannic acid is dissolved in 98g of 50% ethanol / water solution, and the membrane A dried in step S4 is soaked in it for 30min and then dried at 40°C. The dried membrane is stretched by 1 time at 40°C (using a tensile testing machine) to obtain membrane B.

[0104] Product performance testing:

[0105] 1. Tensile strength / elongation at break test: The overall shrinkage performance of the product is determined by the shrinkable layer, so only its tensile strength and rate are tested.

[0106] Cut the membrane from step S6 into strips of 50 mm × 10 mm and measure the thickness D (in mm). Fix both ends of the strip to the clamps of a universal testing machine with a clamp spacing of 20 mm. Then, stretch the strip at a uniform speed of 50 mm / min until it breaks, and record the maximum force F (in N) during this process. The formula for calculating the tensile strength T is as follows:

[0107]

[0108] Where: W is the width of the sample, 10 mm.

[0109] II. Shrinkage Strength / Shrinkage Rate Test: The overall shrinkage performance of the product is determined by the shrinkable layer, so only its shrinkage strength and ratio are tested.

[0110] Cut the membrane from step S6 into 50 mm × 10 mm strips and measure the strip thickness D (in mm). Fix both ends of the strips to the clamps of the universal testing machine, with a clamp spacing of 20 mm. Then spray water onto the strips and record the data and length of the machine's retraction.

[0111] The data calculations are consistent with tensile strength, and the shrinkage rate is the percentage change in length before and after shrinkage.

[0112] III. Adhesion Strength Test: Viscosity determines whether the product will detach upon contact with liquid; therefore, the adhesion strength between the shrinkable layer and the adhesive substrate is tested. Figure 3 Prepare a sample with overlapping dimensions of 1cm x 1cm. Use a tensile testing machine to clamp the sample's base layer and shrinkable layer, and record the maximum value (N) under constant tension.

[0113] IV. Weight loss rate: The maximum usage time of the dressing is 24 hours, therefore the product must maintain contractility for 24 hours and controllable weight loss.

[0114] Take 2.0g of the membrane from step S6 and immerse it in PBS buffer at 37°C for 24 hours. Record the percentage change in weight before and after immersion as the weight loss rate.

[0115] V. Scar Reduction: Rats were anesthetized with 10% chloral hydrate (0.3 ml / kg). The fur on the rats' backs was shaved off with a razor, and the area was disinfected with povidone-iodine. A 1 cm circle was drawn with sterile dye, and the full thickness of the skin within the circle was cut off with ophthalmic scissors. The dressings for the experimental and control groups were applied to the skin. The experimental group used the dressing prepared in Example 1, while the control group used a commercially available sterile dressing. The dressings were changed every 8 hours. Wound healing was measured at 0, 3, 7, 10, and 14 days, the healing rate was calculated, and scar formation was observed (see [reference]). Figure 2 ).

[0116]

[0117]

[0118] The experimental results of Example 1 and Comparative Example 1 show that when the concentration of polyethylene oxide is low, the film formed on the surface in step S6 is easily soluble in water.

[0119] The results of Comparative Example 2 show that polyethylene oxide is extremely difficult to dissolve in water, making it difficult to obtain a 5% aqueous solution.

[0120] The results of Comparative Example 3 show that low molecular weight polyethylene oxide is easily soluble in water after film formation and cannot be used.

[0121] The results of Comparative Example 4 show that high molecular weight polyethylene oxide is difficult to dissolve in water. If it needs to be dissolved, it needs to be dissolved at a very low concentration and then evaporated at high temperature.

[0122] The results of Comparative Example 5 show that when the concentration of plasticizer is low, the film is brittle; the results of Comparative Example 6 show that when there is too much plasticizer, there will be excess precipitation on the product surface, making it oily and affecting the appearance.

[0123] The results of Comparative Example 7 show that the growth-increasing effect of low molecular weight PEG is limited.

[0124] The results of Comparative Example 8 show that low-ratio mixing of solutions results in low solute content, thin film, and easy solubility in water.

[0125] The results of Comparative Example 9 show that the performance of the product obtained after high-proportion mixing of solutions is consistent with that of the example. Considering cost, this parameter is not selected.

[0126] The results of Comparative Examples 10 and 11 show that the stretch ratio of the elastic fabric has a certain impact on the shrinkage of the finished product; the lower the stretch ratio, the smaller the shrinkage force; however, the shrinkage of the product mainly depends on the surface film (Comparative Examples 14 and 15).

[0127] Comparing the results of Examples 12 and 13, it can be seen that if the film-laying ratio in the step is too low, the surface cannot form a film; if it is too thick, it will break under tension.

[0128] The results of Comparative Examples 16 and 17 show that the concentration of tannic acid affects the viscosity of the product. The performance does not change qualitatively when the concentration is higher than the range of the claims, so this parameter is not considered.

[0129] In Comparative Example 18, the water content was too high, causing the uncrosslinked membrane to dissolve in water; in Comparative Example 19, the water content was too high, making the tannic acid unusable.

[0130] The results of Comparative Example 20 show that polyvinylpyrrolidone has the effect of enhancing mechanical properties at a certain ratio.

[0131] The results of Comparative Example 21 show that the product is not cross-linked and is easily soluble in water;

[0132] By comparing the healing rate in mice with that of commercially available sterile dressings in the examples, this product has a healing-promoting effect.

[0133] Unless otherwise specified, all solutions prepared are aqueous solutions;

[0134] This patented invention discloses a dressing that automatically shrinks to reduce scarring after absorbing wound exudate through chemical action. It comprises an adhesive base, a shrinkable layer, an absorbent layer, and a release paper layer. When the product is adhered to the skin surface, it absorbs exudate to maintain a moist environment while the liquid enters the shrinkable layer, causing the entire product to shrink, promoting wound healing and reducing scar formation.

[0135] Finally, it should be noted that the above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A method for preparing a dressing that can reduce scarring, characterized in that, Specifically, the steps include the following: S1. Prepare a 2%~4% polyethylene oxide aqueous solution A; S2. Dissolve polyethylene glycol and glycerin in water to prepare a solution with a concentration of 2% to 4%, then add cyclodextrin and mix and stir to obtain a mixed aqueous solution B; S3. Mix the polyethylene oxide aqueous solution A from step S1 and the mixed aqueous solution B from step S2 in a certain proportion to obtain solution C. S4. Take a non-woven fabric with a spandex content greater than 10%, immerse it in solution C, dry it, and take the membrane to obtain membrane A; The ratio of the area of ​​the nonwoven fabric to the mixed solution C is 1 cm². 2 0.2~2g; S5. Take the membrane dried in step S4 and immerse it in a tannic acid ethanol / water mixed solution; after immersion, dry it at 40~60℃; after drying, stretch and crosslink it at 40~60℃ to obtain membrane B. S6. Immerse the membrane B from step S5 in an anhydrous ethanol solution of polyvinylpyrrolidone and dry it at 40℃~60℃ to obtain a shrinkable layer. S7. A dressing that can reduce scarring is obtained by combining an adhesive base, a shrinkable layer, an absorbent layer, and a release paper. In step S4, the nonwoven fabric is immersed in solution C under a stretched state, wherein the stretch ratio is 2~3; the drying temperature is 40~60℃; in step S5, the tannic acid concentration is 2~10%, the solution is a 50~70% aqueous ethanol solution, the immersion temperature is room temperature, and the time is 25~35min; in step S6, the polyvinylpyrrolidone concentration is 2%~4%, the solvent is anhydrous ethanol, the immersion temperature is room temperature, and the time is 25~35min.

2. The method for preparing a dressing that reduces scarring as described in claim 1, characterized in that: The molecular weight of the polyethylene oxide in step S1 is 500,000 to 2,000,000; the molecular weight of the polyethylene glycol in step S2 is 800 to 2,000.

3. The method for preparing a dressing that reduces scarring as described in claim 1, characterized in that: In step S2, the mass of polyethylene glycol and glycerol is equal; the mass of cyclodextrin is 10 times that of polyethylene oxide.

4. The method for preparing a dressing that reduces scarring as described in claim 1, characterized in that: In step S2, the mixing temperature is 35~65℃ and the time is 10~30min.

5. The method for preparing a dressing that reduces scarring as described in claim 1, characterized in that: In step S3, the ratio of polyethylene oxide aqueous solution A to mixed aqueous solution B is 1:3 to 1:

5.

6. The method for preparing a dressing that reduces scarring as described in claim 1, characterized in that: In step S4, the stretching ratio is 1~2; in step S5, the crosslinking method is formaldehyde fumigation crosslinking, the time is 1h, and the formaldehyde concentration is 4%.

7. A dressing that reduces scarring, characterized in that: It is prepared using the preparation method of a dressing that can reduce scar formation as described in any one of claims 1 to 6.

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