Plant sedative composition

Abstract

Disclosed herein are topical compositions that provide advanced environmental protection to the skin, brighten complexion, and provide anti-aging efficacy to the skin. The topical composition includes a vitamin C source, a copper source, and sodium hyaluronate. Also disclosed herein are methods of administering the topical compositions.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] The present invention claims priority to U.S. Provisional Patent Application No. 63 / 299,209 filed on January 13, 2022, the entire contents of which are incorporated herein. Field of the Invention

[0003] The present invention relates to cosmetic compositions for skin care. Background of the Invention

[0005] Overexposure to the sun and other toxic free radical sources and irritants can cause skin damage, which can lead to a variety of disfiguring skin conditions. Among these skin conditions, wrinkles, fine lines, loss of elasticity, sagging, dryness, age spots are all caused by sun damage and aging. Skin wrinkles are deep grooves, folds or fine lines. Wrinkles can appear anywhere on the body, but are particularly noticeable on areas that receive the strongest sun exposure, such as the face, neck, forearms and hands.

[0006] It is well known that free radicals generated by ultraviolet (UV) light, which increase with air pollution in densely populated areas, exacerbate the problem. Free radicals are destructive because they hydrolyze elastin fibers in the skin and desynthesize collagen in the dermis beneath the skin, causing wrinkles and other destructive skin conditions.

[0007] Today, people often seek ways to prevent and / or counteract the effects of aging and sun exposure. Consumers can use a variety of cosmetic compositions as well as homeopathic remedies to achieve a more youthful and healthy appearance. However, there remains a need for topical compositions that can provide effective treatment and preventive measures against skin photoaging and related skin diseases. Summary of the invention

[0008] It is an object of certain embodiments of the present disclosure to provide topical compositions, methods of making, and methods of using the topical compositions to protect the skin from intrinsic and extrinsic aggressors that may impair the skin's youthful appearance.

[0009] As used herein, the term "applying a topical composition" refers to applying topically to the skin of a subject, such as the face, neck, hands, feet, elbows, knees, etc. As used herein, for the disclosed topical formulations or methods of using the disclosed topical formulations, the terms "application," "application," and "applying" refer to any manner of applying a topical formulation to the skin (e.g., human skin, such as the skin of a patient) that delivers the formulation to the surface of the subject's skin in medical or cosmetic practice. Smearing, rubbing, spreading, spraying (with or without the aid of a suitable device) the disclosed topical formulation on the subject's skin are all included within the scope of the term "application" as used herein. For the application or application of the disclosed skin care formulations, the terms "topical" or "topically" refer to epidermal application or application to the skin. Application can be performed manually (e.g., directly by hand) or by using an applicator, cloth, device, roll-on, wipes, unit dose sponge applicator, liquid applied with a cotton swab or ball, impregnated gauze or other substrate, coated silicone sheet or other sheet-like item, coated bandage or external fixation device, towelette, individually packaged swab, transdermal delivery system, etc. Administration can be self-administered or by a healthcare professional or caregiver.

[0010] In one embodiment of the invention, the topical composition comprises a source of vitamin C, a source of copper, and sodium hyaluronate. In another embodiment, the topical composition may comprise two or more sources of vitamin C, copper, or sodium hyaluronate. In another embodiment, the topical composition may comprise three or more sources of vitamin C, copper, or sodium hyaluronate.

[0011] In certain embodiments of the topical composition, the vitamin C source comprises ascorbic acid, tetrahexyldecanol ascorbate, or a combination thereof.

[0012] In certain embodiments of the topical composition, the copper source comprises copper PCA (pyrrolidone carboxylic acid), copper peptides, or a combination thereof.

[0013] In one embodiment, the topical composition further comprises a source of azelaic acid. The source of azelaic acid may include azelaic acid amino acid potassium salt.

[0014] In certain embodiments, the topical composition further comprises an adaptogen. The adaptogen source comprises Resurgent Power BCR.

[0015] In certain embodiments, the topical composition further comprises an antioxidant system comprising green tea polyphenols.

[0016] In some embodiments, the topical composition further comprises one or more of the following substances: solvents, thickeners, chelating agents, vitamin D, solubilizing agents, melatonin, preservatives, one or more plant extracts, colorants, or combinations thereof. In certain embodiments, the topical composition may comprise a solvent comprising water, glycerin, or a combination thereof. In certain embodiments, the topical composition may comprise a thickener comprising a cellulose thickener, a synthetic polymer thickener, or a combination thereof. In certain embodiments, the topical composition may comprise a solubilizing agent having an HLB greater than 6, preferably a solubilizing agent having an HLB greater than 12. In certain embodiments, the topical composition may comprise one or more plant extracts selected from thyme herb, mulberry extract, willow bark extract, elderberry, echinacea, cucumber-based extract, or a combination thereof.

[0017] In certain embodiments, the topical composition may further include a plant growth factor. In certain embodiments, the plant growth factor may include a plant-based synthetic human epidermal growth factor (EGF), a plant-based synthetic vascular endothelial growth factor (VEGF), a plant-based synthetic transforming growth factor (TGF), a plant-based synthetic insulin growth factor (IGF), or a combination thereof.

[0018] In certain embodiments of the topical composition, the vitamin C source may be present in an amount of about 0.001 wt % to about 20 wt %, about 0.05 wt % to about 10 wt %, about 0.1 wt % to about 5 wt %, or about 1 wt % to about 2.5 wt %, based on the total weight of the topical composition.

[0019] In certain embodiments of the topical composition, the copper source may be present in an amount of about 0.001 wt % to about 5 wt %, about 0.05 wt % to about 4 wt %, about 0.1 wt % to about 3 wt %, or about 1 wt % to about 2.5 wt %, based on the total weight of the topical composition.

[0020] In some embodiments of the topical composition, the sodium hyaluronate may be present in an amount of about 0.1 wt % to about 5 wt %, about 1 wt % to about 4 wt %, or about 2 wt % to about 3 wt %, based on the total weight of the topical composition.

[0021] In some embodiments of the topical composition, the thickener may be included in an amount of about 0 wt % to about 3 wt %, about 0.5 wt % to about 2.5 wt %, or about 1 wt % to about 2 wt %, based on the total weight of the topical composition.

[0022] In some embodiments of the topical composition, the solubilizer may be present in an amount of about 0 wt % to about 10 wt %, about 1 wt % to about 9 wt %, about 2 wt % to about 8 wt %, about 3 wt % to about 7 wt %, or about 4 wt % to about 6 wt %, based on the total weight of the topical composition.

[0023] In some embodiments of the topical composition, the one or more plant extracts may be thyme herb. In some embodiments, the thyme herb may be present in an amount of about 0% to about 10%, about 1% to about 9%, about 2% to about 8%, about 3% to about 7%, or about 4% to about 6% by weight, based on the total weight of the topical composition.

[0024] In some embodiments of the topical composition, the one or more plant extracts may be a mulberry extract. In some embodiments, the mulberry extract may be present in an amount of about 0% to about 10%, about 1% to about 9%, about 2% to about 8%, about 3% to about 7%, or about 4% to about 6% by weight, based on the total weight of the topical composition.

[0025] In some embodiments of the topical composition, the one or more plant extracts may be elderberry. In some embodiments, the elderberry may be present in an amount of about 0% to about 10%, about 1% to about 9%, about 2% to about 8%, about 3% to about 7%, or about 4% to about 6% by weight, based on the total weight of the topical composition.

[0026] In some embodiments of the topical composition, the one or more plant extracts may be willow bark extract. In some embodiments, the willow bark extract may be present in an amount of about 0% to about 10%, about 1% to about 9%, about 2% to about 8%, about 3% to about 7%, or about 4% to about 6% by weight, based on the total weight of the topical composition.

[0027] In some embodiments of topical compositions, the preservative may be phenoxyethanol. In some embodiments of topical compositions, the solvent may include glycerol and water. In some embodiments of topical compositions, the glycerol may be present in an amount of about 0% to about 20% by weight, about 1% to about 15% by weight, about 2% to about 12% by weight, about 3% to about 10% by weight, about 4% to about 8% by weight, or about 5% to about 7% by weight, based on the gross weight of the topical compositions.

[0028] In certain embodiments of the topical composition, the melatonin may be present in an amount of about 0.001 wt % to about 2 wt %, about 0.01 wt % to about 1 wt %, or about 0.1 wt % to about 0.5 wt %, based on the total weight of the topical composition.

[0029] In certain embodiments, the topical composition further comprises allantoin. In some embodiments, the content of allantoin can be from about 0 wt % to about 2 wt %, from about 0.01 wt % to about 1 wt %, or from about 0.1 wt % to about 0.5 wt %, based on the total weight of the topical composition.

[0030] In certain embodiments, the topical composition further comprises DL panthenol. In some embodiments, the content of DL panthenol can be from about 0 wt % to about 5 wt %, from about 1 wt % to about 4 wt %, or from about 2 wt % to about 3 wt %, based on the total weight of the topical composition.

[0031] In certain embodiments, the topical composition further comprises disodium EDTA. In some embodiments, the content of disodium EDTA can be from about 0% to about 1% by weight, from about 0.001% to about 0.9% by weight, from about 0.01% to about 0.75% by weight, or from about 0.1% to about 0.5% by weight, based on the total weight of the topical composition.

[0032] In certain embodiments, the topical composition further comprises a plant growth factor. In some embodiments, the plant growth factor may be present in an amount of about 0.1% to about 10%, about 0.5% to about 9%, about 1% to about 8%, about 2% to about 7%, about 3% to about 6%, or about 4% to about 5% by weight, based on the total weight of the topical composition.

[0033] In another embodiment, a method of treating skin comprises applying a topical composition to the skin.

[0034] In certain embodiments, the present disclosure relates to methods of preparing any topical composition described herein by combining an ascorbate component with greater than 0 wt. % to about 1 wt. % of an antioxidant system including green tea polyphenols. DETAILED DESCRIPTION OF THE INVENTION

[0036] Unless otherwise stated, the following definitions apply.

[0037] As used herein, the term "alkyl" refers to both straight and branched chain hydrocarbon groups. Reference to a single group (eg, propyl) includes only the straight chain group, with branched chain isomers (eg, isopropyl) being specifically mentioned.

[0038]

[0046] The term "halo" or "halogen" as used herein refers to fluorine, chlorine, bromine and iodine.

[0039] The term "carbocycle" or "carbocyclyl" refers to a single saturated (i.e., cycloalkyl) or single partially unsaturated (e.g., cycloalkenyl, cycloalkadienyl, etc.) ring having 3 to 7 carbon atoms (i.e., (C3-C7) carbocycle). The term "carbocycle" or "carbocyclyl" also includes multiple fused ring systems (e.g., ring systems containing 2, 3, or 4 carbocycles). Thus, carbocycles include polycyclic carbocycles having 7 to 12 carbon atoms as bicyclic rings, and polycyclic carbocycles having up to about 20 carbon atoms as polycyclic rings. Polycyclic carbocycles may be linked to each other through single carbon atoms to form a spiro connection (e.g., spiropentane, spiro[4,5]decane, spiro[4.5]decane, etc.), linked to each other through two adjacent carbon atoms to form a fused connection such as a bicyclo[4,5], [5,5], [5,6] or [6,6] system, or 9 or 10 ring atoms arranged to form a bicyclo[5,6] or [6,6] system (e.g., decahydronaphthalene, norsabinane, norcarane), or bridged through two non-adjacent carbon atoms (e.g., norbornane, bicyclo[2.2.2]octane, etc.). "Carbocycle" or "carbocyclyl" may also be optionally substituted with one or more (e.g., 1, 2 or 3) oxo groups. Non-limiting examples of monocyclic carbocycles include cyclopropyl, cyclobutyl, cyclopentyl, 1-cyclopent-1-enyl, 1-cyclopent-2-enyl, 1-cyclopent-3-enyl, cyclohexyl, 1-cyclohex-1-enyl, 1-cyclohex-2-enyl, 1-cyclohex-3-enyl, and cycloheptyl.

[0040] The term "aryl" as used herein refers to a single aromatic ring or a plurality of fused ring systems. For example, an aryl group may have 6 to 20 carbon atoms, 6 to 14 carbon atoms, or 6 to 12 carbon atoms. An aryl group includes a phenyl group. An aryl group also includes a plurality of fused ring systems (e.g., a ring system comprising 2, 3, or 4 rings) having about 9 to 20 carbon atoms, wherein at least one ring is aromatic. Such a plurality of fused ring systems may optionally be substituted with one or more (e.g., 1, 2, or 3) oxo groups on any carbocyclic portion of the plurality of fused ring systems. It should be understood that the connection point of the plurality of fused ring systems as defined above may be located at any position of the ring system, including the aryl or carbocyclic portion of the ring. Typical aryl groups include, but are not limited to, phenyl, indenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, anthracenyl, etc.

[0041] It will be appreciated by those skilled in the art that compounds of the invention having chiral centers may exist and be separated in optically active forms and racemic forms. Some compounds may exhibit polymorphism. It will be appreciated that the invention encompasses any racemic, optically active, polymorphic or stereoisomeric forms of compounds of the invention, or mixtures thereof, having the useful properties described herein, and it is well known in the art how to prepare optically active forms (e.g., by resolving racemic forms by recrystallization techniques, by synthesis from optically active starting materials, by chiral synthesis, or by chromatographic separation using a chiral stationary phase).

[0042] As used herein, "free or substantially free" means that the topical composition contains less than about 1 wt %, less than about 0.5 wt %, less than about 0.25 wt %, less than about 0.1 wt %, less than about 0.05 wt %, less than about 0.01 wt %, or 0 wt % of the recited component.

[0043] As used herein, when referring to growth factors, the term "plant synthetic" refers to a plant that has been bioengineered so that the plant or an extract thereof is capable of acting as a growth factor.

[0044] Topical compositions

[0045] According to various embodiments, the present disclosure relates to a topical composition comprising a continuous phase and a dispersed phase. The topical composition comprises an ascorbic acid component and a copper component. In certain embodiments, the topical composition further comprises at least one additional cosmetically acceptable excipient.

[0046] The ascorbic acid component of any topical composition described herein may include ascorbic acid or a derivative thereof, such as ascorbyl palmitate, sodium ascorbate, potassium ascorbate, ammonium ascorbate, triethanolamine ascorbate, ascorbyl phosphate or magnesium ascorbyl phosphate, ascorbic acid polypeptides, ascorbyl glucosamine, ascorbic acid polymers, ascorbic acid esters, ascorbic acid amides, L-ascorbic acid, tetrahexyldecyl ascorbate (known as vitamin C), or other derivatives or related compounds, including plant or herbal extracts, such as acerola extract, citrus extract, strawberry extract, which can provide L-ascorbic acid or a derivative thereof. In certain embodiments, the ascorbic acid component of the topical composition includes ascorbic acid, tetrahexyldecyl ascorbate, or a combination thereof.

[0047] The ascorbic acid component in any topical composition described herein can be present in any concentration from about 0.001 wt %, 0.01 wt %, 0.1 wt %, about 1 wt %, about 5 wt %, about 10 wt % to about 12 wt %, about 15 wt %, about 18 wt %, or about 20 wt %, based on the total weight of the topical composition. In certain embodiments, the ascorbic acid component in any topical composition described herein is present in an amount from about 0.001 wt % to about 20 wt %, from about 0.05 wt % to about 10 wt %, from about 0.1 wt % to about 5 wt %, or from about 1 wt % to about 2.5 wt %, based on the total weight of the topical composition.

[0048] The copper component of any of the topical compositions described herein can include copper pyrrolidone carboxylic acid ("PCA"), copper peptides, or a combination thereof.

[0049] The copper component in any topical composition described herein can be present in any concentration from about 0.001%, about 0.01%, about 0.1%, about 1% to about 2%, about 2.5%, about 3%, about 4%, about 5% by weight based on the total weight of the topical composition.

[0050] The sodium hyaluronate in the topical composition can be present in any concentration from about 0.1 wt%, about 1 wt%, or about 2 wt% to about 3 wt%, 4 wt%, or 5 wt%, based on the total weight of the topical composition. The concentration of sodium hyaluronate in the topical composition can also be greater than 0 to about 5 wt%.

[0051] Certain plants containing high levels of polyphenols (such as green tea) are included in any topical composition described herein. The antioxidant system in the topical composition described herein can be present in any concentration from greater than 0%, about 0.01%, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, or about 0.4% to about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.75%, about 0.8%, about 0.85%, about 0.9%, about 0.95%, or about 1% by weight, based on the total weight of the topical composition.

[0052] In certain embodiments, the topical composition includes an antioxidant system comprising any of the green tea polyphenols described herein in combination with at least one additional antioxidant.

[0053] In one embodiment, the additional antioxidants in the antioxidant system may be selected from cinnamic acid, ferulic acid, caffeic acid, p-coumaric acid, sinapinic acid, cis- and trans-isomers thereof, salts thereof, equivalent derivatives thereof, and combinations thereof. In another embodiment, the additional antioxidants in the antioxidant system (and in the topical composition in general) may be free or substantially free of cinnamic acid, ferulic acid, caffeic acid, p-coumaric acid, sinapinic acid, cis- and trans-isomers thereof, salts thereof, equivalent derivatives thereof, and combinations thereof.

[0054] In certain embodiments, the additional antioxidant in the antioxidant system can be selected from gallic acid, delphinidin, luteolin, quercetin, cyanidin, taxifolin, kaempferol, malvidin, hesperidin, pelargonidin, apigenin, naringenin, chrysin, ergothioneine, cis and trans isomers thereof, salts thereof, equivalent derivatives thereof, and combinations thereof.

[0055] In certain embodiments, the additional antioxidant in the antioxidant system may be selected from apigenin, ergothioneine, cis and trans isomers thereof, salts thereof, equivalent derivatives thereof, and combinations thereof.

[0056] Each antioxidant in the antioxidant system can be present individually or cumulatively at a concentration of any of 0 wt %, about 0.01 wt %, about 0.05 wt %, about 0.1 wt %, about 0.15 wt %, about 0.2 wt %, about 0.25 wt %, about 0.3 wt %, about 0.35 wt %, or about 0.4 wt % to about 0.45 wt %, about 0.5 wt %, about 0.55 wt %, about 0.6 wt %, about 0.65 wt %, about 0.7 wt %, about 0.75 wt %, about 0.8 wt %, about 0.85 wt %, about 0.9 wt %, about 0.95 wt %, or about 1 wt %, based on the total weight of the topical composition.

[0057] In certain embodiments, the antioxidant system comprises green tea polyphenols in an amount of greater than 0 wt % to about 0.5 wt %, greater than 0 wt % to about 0.1 wt %, or greater than 0 wt % to about 0.01 wt %, based on the total weight of the topical composition.

[0058] In some embodiments, the topical composition comprises a source of azelaic acid. The source of azelaic acid can be azelaic acid potassium salt (azeloglicina).

[0059] In some embodiments, the topical composition comprises an adaptogen. The adaptogen may include Resurgent Power BCR.

[0060] In some embodiments, the topical composition further comprises one or more of the following: a solvent, a thickener, a chelating agent, vitamin D, a solubilizing agent, melatonin, a preservative, at least one plant extract, or a colorant.

[0061] Suitable solvents for use in the topical compositions described herein include, but are not limited to, polysorbate 20, water, an alkylene glycol (e.g., ethylene glycol, propylene glycol, butylene glycol), an ethoxylated or propoxylated diglycol, ethanol, propanol, isopropanol, glycerin, methoxyisopropanol, PPG-2 methyl ether, PPG-3 methyl ether, propylene glycol butyl ether, PPG-2 butyl ether, phenoxyisopropanol, butoxyethanol, butoxydiglycol, methoxydiglycol, phenoxyethanol, PPG-3 butyl ether, PPG-2 propyl ether, propylene glycol propyl ether, or dipropylene glycol dimethyl ether, or mixtures thereof.

[0062] In certain embodiments, the solvent can be water, glycerin, or a combination thereof. In some embodiments, the glycerin is present in an amount of about 0%, about 1%, about 2%, about 3%, about 4%, or about 5% to about 7%, about 8%, about 10%, about 12%, about 15%, or about 20% by weight based on the total weight of the topical composition.

[0063] In certain embodiments, the thickener may include a cellulosic thickener, a synthetic polymer thickener, or a combination thereof. The thickener may be included in the topical composition in any of the following amounts, based on the total weight of the topical composition: about 0 wt %, about 0.5 wt %, about 1 wt % to about 2 wt %, about 2.5 wt %, or about 3 wt %.

[0064] In certain embodiments, the solubilizer may have an HLB greater than 6, preferably an HLB greater than 12. The solubilizer may be included in the topical composition in any of the following amounts, based on the total weight of the topical composition: about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt% to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%.

[0065] In certain embodiments, the plant extract can be thyme herb, mulberry extract, willow bark extract, elderberry, echinacea, cucumber-based extract, or a combination thereof.

[0066] In some embodiments, the plant extract is thyme herb. Based on the total weight of the topical composition, the thyme herb is present in an amount of about 0%, about 1%, about 2%, about 3%, about 4%, or about 5% to about 6%, about 7%, about 8%, about 9%, or about 10% by weight.

[0067] In some embodiments, the plant extract is a mulberry extract. Based on the total weight of the topical composition, the mulberry extract is present in an amount of about 0%, about 1%, about 2%, about 3%, about 4%, or about 5% to about 6%, about 7%, about 8%, about 9%, or about 10% by weight.

[0068] In some embodiments, the plant extract is elderberry. The elderberry is present in an amount of about 0%, about 1%, about 2%, about 3%, about 4%, or about 5% to about 6%, about 7%, about 8%, about 9%, or about 10% by weight based on the total weight of the topical composition.

[0069] In some embodiments, the plant extract is willow bark extract. Based on the total weight of the topical composition, the willow bark extract is present in an amount of about 0 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, or about 5 wt% to about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, or about 10 wt%.

[0070] In certain embodiments, the preservative is phenoxyethanol.

[0071] In some embodiments, the topical composition further comprises melatonin. Based on the total weight of the topical composition, the content of melatonin can be about 0.001 wt%, about 0.01 wt%, or about 0.1 wt% to about 0.5 wt%, about 1 wt%, or about 2 wt%.

[0072] In some embodiments, the topical composition further comprises allantoin. Based on the total weight of the topical composition, the allantoin may be present in an amount of about 0.001 wt%, about 0.01 wt%, or about 0.1 wt% to about 0.5 wt%, about 1 wt%, or about 2 wt%.

[0073] In some embodiments, the topical composition further comprises DL panthenol. The content of DL panthenol can be about 0 wt%, about 1 wt%, or about 2 wt% to about 3 wt%, about 4 wt%, or about 5 wt%, based on the total weight of the topical composition.

[0074] In some embodiments, the topical composition further comprises disodium edetate. Based on the total weight of the topical composition, the content of disodium edetate may be any of about 0 wt%, about 0.001 wt%, about 0.01 wt%, about 0.1 wt% to about 0.5 wt%, about 0.75 wt%, about 0.9 wt%, or about 1 wt%.

[0075] In some embodiments, the topical composition further comprises a plant growth factor. In some embodiments, the plant growth factor may include a plant-based synthetic human epidermal growth factor (EGF), a plant-based synthetic vascular endothelial growth factor (VEGF), a plant-based synthetic transforming growth factor (TGF), a plant-based synthetic insulin growth factor (IGF), or a combination thereof. For example, the plant growth factor may be Or a combination thereof (produced by Lipotrue). In some embodiments, the plant growth factor may be present in an amount of about 0.1% to about 10% by weight, about 0.5% to about 9% by weight, about 1% to about 8% by weight, about 2% to about 7% by weight, about 3% to about 6% by weight, about 4% to about 5% by weight, or about 1% to about 2% by weight, based on the total weight of the topical composition.

[0076] In certain embodiments, the topical composition further comprises a cosmetically acceptable excipient. Exemplary cosmetically acceptable excipients include, but are not limited to, epidermal penetration enhancers, solvents, mild surfactants, oil bodies, emulsifiers, pearlescent waxes, consistency regulators, thickeners, rheology modifiers, suspending agents, chelating agents, preservatives, superfatting agents, stabilizers, polymers, silicone or siloxane compounds, fats, waxes, lecithin, phospholipids, ultraviolet light protection factors, biologically active ingredients, additional antioxidants, deodorants, antiperspirants, antidandruff agents, film formers, bulking agents, insect repellents, self-tanning agents, tyrosinase inhibitors, hydrotropes, solubilizers, fragrance oils, dyes, zinc oxide, fatty alcohols, fatty acid esters, adjuvants, natural or synthetic triglycerides (including glycerides and derivatives), hydrocarbon oils, superfatting agents, polymers, biologically active ingredients, hydrotropes, antibacterial agents, colorants, ultraviolet light shielding agents, agents that absorb ultraviolet light and provide light protection to the skin, or combinations thereof. In certain embodiments, the topical composition comprises a cosmetically acceptable excipient selected from solvents, emulsifiers, consistency regulators, thickeners, suspending agents, additional antioxidants, preservatives, fragrance oils, or combinations thereof. In certain embodiments, the topical composition is free or substantially free of silicone compounds.

[0077] In certain embodiments, the cosmetically acceptable excipient includes glycerin in the topical composition in an amount from about 2 wt % to about 25 wt %, from about 5 wt % to about 15 wt %, or from about 8 wt % to about 12 wt % based on the total weight of the topical composition.

[0078] In certain embodiments, the cosmetically acceptable excipient includes water in the topical composition in an amount of about 5 wt % to about 95 wt %, about 10 wt % to about 95 wt %, about 20 wt % to about 80 wt %, about 35 wt % to about 70 wt %, or about 50 wt % to about 60 wt %, based on the total weight of the topical composition.

[0079] In certain embodiments, the cosmetically acceptable excipients include a viscosity agent. The viscosity agent may include xanthan gum, such as Keltrol Advanced Performance LAX-T.

[0080] In certain embodiments, the cosmetically acceptable excipient comprises a chelating agent. Suitable chelating agents include, but are not limited to, disodium ethylenediaminetetraacetate (EDTA), diethylenetriaminepentaacetic acid (DTPA), N-(hydroxyethyl)-ethylenediaminetriacetic acid (HEDTA), tetrasodium glutamate diacetate (GLDA), and nitrilotriacetic acid (NTA).

[0081] How to use

[0082] In some embodiments, the present disclosure relates to a method for treating free radical-induced damage to a subject's skin. Free radical-induced damage may include free radical-induced damage from sunlight (UVB, UVA, visible light), HEV (blue) light, infrared (IR), pollution, irritants, allergens, and various environmental toxins that are destructive to the skin, such as by hydrolyzing elastin fibers in the skin and desynthesizing collagen in the dermis below the skin. Exemplary free radical-induced damage that can be treated, prevented, minimized, mitigated, or attenuated after applying an effective amount of any topical composition described herein to the subject's skin includes, but is not limited to, the appearance of skin wrinkles, fine lines, skin roughness, skin sagging, skin firmness, reduced skin elasticity, age spots, hyperpigmentation, scars, skin surface irregularities, rosacea, acne, psoriasis, reduced skin regeneration and renewal processes, a weathered appearance, yellowing, redness, dryness, ichthyosis, and other destructive skin diseases.

[0083] In certain embodiments, the present disclosure relates to methods of lightening the skin of a subject by applying to the subject's skin an effective amount of any of the topical compositions described herein, wherein the skin is lightened following application of the topical composition.

[0084] In certain embodiments, the present disclosure is directed to methods of treating the effects of atmospheric aging on a subject's skin by administering to the subject's skin an effective amount of any of the topical compositions described herein, wherein following administration the skin exhibits a reduction or attenuation of the effects of atmospheric aging.

[0085] In certain embodiments, the disclosure relates to a treatment regimen method, which includes applying an effective amount of any topical composition described herein to the skin of a subject who has undergone dermatological surgery. Dermatological surgery that may be beneficial to the subsequent (i.e., postoperative) application of the topical composition described herein includes, but is not limited to, non-ablative dermatological surgery, chemical peels, microabrasion, lasers, etc. In certain embodiments, dermatological surgery that may be beneficial to the subsequent (i.e., postoperative) application of the topical composition described herein includes microdermabrasion, intense pulsed light (IPL) or non-ablative laser surgery. In certain embodiments, according to the treatment regimen, the method described herein also includes performing dermatological surgery after applying the topical composition and / or before applying the topical composition.

[0086] As used herein, the terms "treatment" or "treating" for skin disorders generally mean "having a positive effect on the skin disorder" and include reducing, ameliorating and / or alleviating at least one symptom of the skin disorder, alleviating, ameliorating and / or alleviating the severity of the skin disorder, or delaying, preventing or inhibiting the progression of the skin disorder. Thus, treatment as used herein does not require a complete cure of the disorder. The disclosed formulations or methods of treating skin disorders that can be used to treat skin disorders need only reduce the severity of the skin disorder, reduce the severity of the symptoms associated therewith, provide an improvement in the patient's quality of life, or delay, prevent or inhibit the onset of one or more symptoms of the skin disorder. As used herein, these terms also include aesthetic improvements to the skin after application of the disclosed formulations having, for example, a combination of ascorbic acid components and green tea polyphenols.

[0087] As used herein, the phrase "effective amount" refers to an amount of the topical composition of the present disclosure or its components that is effective to treat the above-mentioned skin conditions, which includes a range of effects, from detectable local improvement in the area of ​​topical application to significant relief of symptoms, to improvement in one or more aesthetic criteria, including but not limited to noticeable improvement in free radical damage from sunlight (UVB, UVA, visible light), HEV (blue) light, infrared (IR), pollution, irritants, allergens and various environmental toxins, skin wrinkles, the appearance of fine lines, skin roughness, skin sagging, skin firmness, decreased skin elasticity, age spots, hyperpigmentation, scarring, skin surface irregularities, rosacea, acne, psoriasis, skin regeneration and renewal processes, a weathered appearance, yellowing, redness, dryness, ichthyosis and other destructive skin diseases.

[0088] The effective amount will vary with the specific condition or conditions being treated, the severity of the condition, the duration of treatment, the specific ingredients of the composition used, and other factors. In certain embodiments, the topical compositions described herein are suitable for administration by frequent regular applications (e.g., once, twice, three times, or four times a day or more), for example, for a duration of at least 1 day, at least 3 days, at least 5 days, at least 7 days, at least 10 days, at least 14 days, at least 21 days, at least 30 days, etc. Thus, in certain embodiments, the methods described herein further comprise periodic repeated applications of the topical composition.

[0089] In certain embodiments, the topical compositions described herein are suitable for pre- or post-operative administration (eg, pre- or post-dermatological surgery).

[0090] In certain embodiments, since the topical compositions described herein are emulsions of an aqueous phase and an oil phase, the two phases may separate during storage. Therefore, in certain embodiments, the methods described herein further comprise shaking the topical composition prior to administration to evenly disperse the oil phase in the aqueous phase.

[0091] Preparation method

[0092] The present disclosure also relates to a method for preparing any topical composition described herein. The method comprises preparing any topical composition described herein by combining an ascorbic acid component, greater than 0% to about 1% by weight of an antioxidant system comprising green tea polyphenols, and optionally at least one cosmetically acceptable excipient.

[0093] The topical composition can be formulated as a serum, gel, lotion, cream, pad applied formulation, and the like.

[0094] Illustrative Embodiments

[0095] The following examples are listed to help understand the present invention and should not be construed as specifically limiting the present invention described and claimed herein. Such variations of the present invention, including substitution of all equivalents now known or later developed, will be within the purview of those skilled in the art, as well as minor changes to formulations or experimental designs, should be considered to fall within the scope of the present invention incorporated herein.

[0096] Example 1

[0097] Topical compositions according to embodiments described herein are formulated into a serum having the composition described below in Table 1. The serum is an emulsion of water and oil phases with a pH ranging from about 2.5 to about 3.5.

[0098] Table 1 – Essence composition

[0099] Element Amount (weight %) water 50 wt% - 60 wt% ascorbic acid 10 wt% - 20 wt% Tetrahexyldecyl ascorbate 2 wt% - 10 wt% Green Tea Polyphenols More than 0 wt% - 0.01 wt% Apigenin More than 0 wt% - 0.01 wt% Ergothioneine More than 0 wt% - 0.01 wt% Sclerotium 0.2 wt% - 0.8 wt% Disodium EDTA 0.05 wt% - 0.3 wt% glycerin 5 wt% - 15 wt% Propylene glycol 5 wt% - 15 wt% Tocopheryl acetate 0.5 wt% - 2 wt% PEG-7 Olivate 0.2 wt% - 0.8 wt% Lavender essential oil 0.01 wt% - 0.3 wt% Chamomile essential oil 0.01 wt% - 0.3 wt% Phenoxyethanol 0.5 wt% - 2 wt%

[0100] For ease of explanation, the embodiments of the disclosed method are depicted and described as a series of behaviors. However, behaviors according to the present disclosure may occur in various orders and / or simultaneously, and occur with other behaviors not presented and described herein. In addition, not all illustrated behaviors are required to implement the methods according to the disclosed subject matter. In addition, those skilled in the art will understand and appreciate that these methods may alternatively be represented as a series of interrelated states by state diagrams or events.

[0101] In the foregoing description, many specific details, such as specific materials, dimensions, process parameters, etc., are set forth to provide a thorough understanding of the present invention. In one or more embodiments, specific features, structures, materials or characteristics may be combined in any suitable manner. The words "embodiment" or "exemplary" used herein mean to be used as examples, instances or illustrations. Any aspect or design described herein as "embodiment" or "exemplary" is not necessarily to be interpreted as being superior to or advantageous to other aspects or designs. On the contrary, the use of words such as "embodiment" or "exemplary" is intended to present concepts in a specific manner. As used in this application, the term "or" is intended to represent an inclusive "or" rather than an exclusive "or". That is, unless otherwise stated or clear from the context, "X includes A or B" is intended to represent any naturally included arrangement. That is, if X includes A; X includes B; or X includes both A and B, then "X includes A or B" satisfies any of the above situations. In addition, the article "one" used in this application and the appended claims should generally be interpreted as meaning "one or more", unless otherwise stated or the context clearly indicates a singular form. References throughout this specification to "an embodiment," "some embodiments," or "an embodiment" mean that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the phrases "an embodiment," "some embodiments," or "an embodiment" appearing in various places throughout this specification are not necessarily all referring to the same embodiment.

[0102] References to numerical ranges throughout this specification should not be construed as limiting, but should be understood to encompass the outer limits of the range and every number within the recited numerical range and / or narrower ranges.

[0103] When referring to physical quantities, the term "about" should be understood to include measurement errors within 10%. For example, "about 100°C" should be understood as "100±10°C".

[0104] The present invention has been described with reference to specific exemplary embodiments of the present invention. Therefore, the description and drawings are to be regarded as illustrative rather than restrictive. Various modifications of the present invention, in addition to those shown and described herein, will become apparent to those skilled in the art and are intended to fall within the scope of the appended claims.

Claims

1. A topical composition comprising: Source of vitamin C; Copper source; and Sodium hyaluronate.

2. The topical composition according to claim 1, wherein the vitamin C source comprises ascorbic acid, tetrahexyldecyl ascorbate, or a combination thereof.

3. The topical composition according to claim 1, wherein the copper source comprises copper PCA (pyrrolidone carboxylic acid), copper peptides, or a combination thereof.

4. The topical composition according to claim 1 further comprising a source of azelaic acid.

5. A topical composition according to claim 4, wherein the source of azelaic acid comprises azelaic acid amino acid potassium salt.

6. The topical composition according to claim 1, further comprising an adaptogen.

7. A topical composition according to claim 6, wherein the adaptogen source comprises Resurgent Power BCR.

8. The topical composition according to claim 1, further comprising an antioxidant system comprising green tea polyphenols.

9. A topical composition according to any one of the preceding claims, further comprising one or more of the following: a solvent, a thickener, a chelating agent, vitamin D, a solubilizing agent, melatonin, a preservative, one or more plant extracts, a colorant, or a combination thereof.

10. A topical composition according to claim 9 comprising a solvent comprising water, glycerin or a combination thereof.

11. The topical composition according to claim 9, comprising a thickener comprising a cellulosic thickener, a synthetic polymer thickener, or a combination thereof.

12. A topical composition according to claim 9 comprising a solubilizer having an HLB greater than 6, preferably a solubilizer having an HLB greater than 12.

13. A topical composition according to claim 9, comprising one or more plant extracts selected from thyme herb, mulberry extract, willow bark extract, elderberry, echinacea, cucumber-based extracts, or combinations thereof.

14. The topical composition according to claim 1, wherein the vitamin C source is present in an amount of about 0.001 wt % to about 20 wt %, about 0.05 wt % to about 10 wt %, about 0.1 wt % to about 5 wt %, or about 1 wt % to about 2.5 wt %, based on the total weight of the topical composition.

15. The topical composition according to claim 1, wherein the copper source is present in an amount of about 0.001 wt % to about 5 wt %, about 0.05 wt % to about 4 wt %, about 0.1 wt % to about 3 wt %, or about 1 wt % to about 2.5 wt %, based on the total weight of the topical composition.

16. The topical composition according to claim 1, wherein the sodium hyaluronate is present in an amount of about 0.1 wt% to about 5 wt%, about 1 wt% to about 4 wt%, or about 2 wt% to about 3 wt%, based on the total weight of the topical composition.

17. The topical composition according to claim 11, wherein the thickener is present in an amount of about 0 wt% to about 3 wt%, about 0.5 wt% to about 2.5 wt%, or about 1 wt% to about 2 wt%, based on the total weight of the topical composition.

18. The topical composition according to claim 12, wherein the solubilizing agent is present in an amount of about 0 wt % to about 10 wt %, about 1 wt % to about 9 wt %, about 2 wt % to about 8 wt %, about 3 wt % to about 7 wt %, or about 4 wt % to about 6 wt %, based on the total weight of the topical composition.

19. The topical composition according to claim 13, wherein the one or more plant extracts is thyme herb.

20. The topical composition according to claim 19, wherein the thyme herb is present in an amount of about 0 wt % to about 10 wt %, about 1 wt % to about 9 wt %, about 2 wt % to about 8 wt %, about 3 wt % to about 7 wt %, or about 4 wt % to about 6 wt %, based on the total weight of the topical composition.

21. The topical composition according to claim 13, wherein the one or more plant extracts is a mulberry extract.

22. The topical composition according to claim 21, wherein the mulberry extract is present in an amount of about 0 wt % to about 10 wt %, about 1 wt % to about 9 wt %, about 2 wt % to about 8 wt %, about 3 wt % to about 7 wt %, or about 4 wt % to about 6 wt %, based on the total weight of the topical composition.

23. The topical composition according to claim 13, wherein the one or more plant extracts is elderberry.

24. The topical composition according to claim 23, wherein the elderberry is present in an amount of about 0 wt % to about 10 wt %, about 1 wt % to about 9 wt %, about 2 wt % to about 8 wt %, about 3 wt % to about 7 wt %, or about 4 wt % to about 6 wt %, based on the total weight of the topical composition.

25. The topical composition according to claim 13, wherein the one or more plant extracts is willow bark extract.

26. The topical composition according to claim 25, wherein the willow bark extract is present in an amount of about 0 wt % to about 10 wt %, about 1 wt % to about 9 wt %, about 2 wt % to about 8 wt %, about 3 wt % to about 7 wt %, or about 4 wt % to about 6 wt %, based on the total weight of the topical composition.

27. The topical composition according to claim 9, wherein the preservative is phenoxyethanol.

28. The topical composition according to claim 10, wherein the solvent comprises glycerin and water.

29. The topical composition according to claim 28, wherein the glycerin is present in an amount of from about 0 wt % to about 20 wt %, from about 1 wt % to about 15 wt %, from about 2 wt % to about 12 wt %, from about 3 wt % to about 10 wt %, from 4 wt % to about 8 wt %, or from about 5 wt % to about 7 wt %, based on the total weight of the topical composition.

30. The topical composition according to claim 9, wherein the melatonin is present in an amount of about 0.001 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%, or about 0.1 wt% to about 0.5 wt%, based on the total weight of the topical composition.

31. A topical composition according to claim 1 further comprising allantoin.

32. The topical composition according to claim 31, wherein the allantoin is present in an amount of about 0 wt% to about 2 wt%, about 0.01 wt% to about 1 wt%, or about 0.1 wt% to about 0.5 wt%, based on the total weight of the topical composition.

33. A topical composition according to claim 1 further comprising DL panthenol.

34. The topical composition according to claim 33, wherein the DL panthenol is present in an amount of from about 0 wt% to about 5 wt%, from about 1 wt% to about 4 wt%, or from about 2 wt% to about 3 wt%, based on the total weight of the topical composition.

35. A topical composition according to claim 1 further comprising disodium EDTA.

36. The topical composition according to claim 35, wherein the amount of disodium EDTA is from about 0 wt % to about 1 wt %, from about 0.001 wt % to about 0.9 wt %, from about 0.01 wt % to about 0.75 wt %, or from about 0.1 wt % to about 0.5 wt %, based on the total weight of the topical composition.

37. A topical composition according to claim 1 further comprising a plant-based growth factor.

38. A topical composition according to claim 37, wherein the plant-based growth factor comprises a plant-based synthetic human epidermal growth factor (EGF), a plant-based synthetic vascular endothelial growth factor (VEGF), a plant-based synthetic transforming growth factor (TGF), a plant-based synthetic insulin growth factor (IGF), or a combination thereof.

39. A topical composition according to claim 37, wherein the plant-based growth factor is present in an amount of about 0.1 wt % to about 10 wt %, about 0.5 wt % to about 9 wt %, about 1 wt % to about 8 wt %, about 2 wt % to about 7 wt %, about 3 wt % to about 6 wt %, or about 4 wt % to about 5 wt %, based on the total weight of the topical composition.

40. Methods of treating the skin, including: Applying to the skin a topical composition according to any one of claims 1 to 39.