Method for preventing, relieving and / or treating PTGS2-induced skin disorders and related dysfunctions

Abstract

A non-therapeutic method for preventing, ameliorating or treating human skin disorders and related dysfunctions induced by PTGS2 is proposed, comprising or consisting of the following steps:-administering to the human skin an effective amount of a carnosine compound # imgabs0 # according to formula (I) wherein R1 represents H or CH3 and R2 represents H or COOH.

Description

Field of the Invention

[0001] The present invention relates to the field of cosmetics and to a non-therapeutic method for treating certain skin disorders and related dysfunctions and to a medicament for treating such disorders and dysfunctions. Background of the Invention

[0003] Prostaglandin endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2), is an inflammatory enzyme involved in the biosynthesis of prostaglandins. It is strongly induced by many stimuli - including growth factors, cytokines and solar radiation - leading to the production of prostaglandins during inflammatory processes. Therefore, inhibition of PTGS2 is a way to prevent human skin disorders such as inflammatory, aging and carcinogenic processes, as well as pain and fever, especially (but not limited to) dysfunction caused by solar radiation.

[0004] Various PTGS2 inhibitors are known from cancer and osteoarthritis research, for example:

[0005]

[0006] All of these ingredients are pharmaceutical products with strict dosage regulations and therefore require a prescription. Therefore, these substances are not suitable for use in cosmetics.

[0007] Related prior art

[0008] From a study by Aruoma et al. in 1989, it is known that carnosine can scavenge ROS ("reactive oxygen species") [Biochem. J. 264 (3), p. 863-869 (1989)]. According to a report by Babizhayev et al., carnosine can further scavenge α-β-unsaturated aldehydes released during the peroxidation of cell membrane fatty acids under oxidative stress [Membrane & Cell Biol. 12 (1), PP. 89-99 (1998)].

[0009] EP 1310238 A2 (BASF) discloses cosmetic or dermatological photoprotective compositions and their use, the compositions comprising at least one cholesteric liquid crystal component reflecting in the infrared wavelength range of 750 nm to 2500 nm, at least one filter substance protecting against radiation in the ultraviolet range of 280 nm to 449 nm, and at least one cosmetically acceptable carrier. In addition, antioxidants such as carnosine may also be present.

[0010] EP 1388339 A1 (VISA) discloses the use of carnosine to control the aging process by reversing, preventing and reducing skin wrinkles. Carnosine is described as an anti-wrinkle agent which, among other actions, prevents glycation and chronic inflammation.

[0011] EP 1591105 A1 (STADA) relates to cosmetic and pharmaceutical preparations containing antioxidants which protect the skin from infrared radiation. Among the many possible antioxidants, carnosine is mentioned. In addition, the composition to be applied topically contains one or more inorganic and / or organic UV filters.

[0012] EP 2545898 A1 (COTY) discloses a composition for protecting the skin from infrared radiation, comprising plant extracts, vitamins, ruby ​​powder, mica and titanium dioxide. Section

[0026] also mentions carnosine as another suitable excipient, but as a free radical scavenger.

[0013] WO 1990 006102 A1 (PEPTIDE TECHNOLOGY) also relates to the antioxidant capacity of carnosine compounds. It mainly discloses that the discovered compounds reduce or prevent collagen cross-linking and / or DNA skin cell damage in the skin, especially damage caused by aging or ultraviolet radiation. It is used by topical application or injection.

[0014] WO 2010 124817 A2 (KPSS) relates to conditioning agents for hair based on dipeptides, such as carnosine.

[0015] WO 2014 128228 A2 (SYMRISE) demonstrates the suitability of carnosine for protecting the skin from infrared radiation on the basis of inhibiting the expression of MMPs. EP 3 389621 A1 (SYMRISE) relates to an emulsion comprising carnosine and a UV filter.

[0016] US 2006 216251 A1 (TRACIE MARTIN) relates to a topical composition containing carnosine, carnitine and lipoic acid for treating and protecting the skin, in particular against signs of skin aging associated with chronic aging or photoaging, which targets wrinkles, skin weakening and loss of elasticity. Treatment for hyperpigmentation is also disclosed. The effect of carnosine on MMP-1 inhibition is also noted.

[0017] KR 2004 0074795 A (AE KYUNG) discloses that 0.1 to 2 wt% of carnosine in a cosmetic composition exhibits an antioxidant effect on the skin and increases collagen synthesis.

[0018] Purpose of the Invention

[0019] Therefore, the object of the present invention is to find a cosmetic active ingredient that can inhibit the expression of PTGS2 to prevent, alleviate or treat skin disorders and / or functional disorders caused by increased PTGS2 expression, such as inflammation, aging, skin cancer, as well as fever and pain.

[0020] Specific content of the invention The first object of the present invention relates to a non-therapeutic method for preventing, alleviating or treating PTGS2-induced human skin disorders and related functional disorders, which comprises or consists of the following steps:

[0021] - Applying an effective amount of a carnosine compound according to formula (I) to human skin

[0022]

[0023] Wherein R1 represents H or CH3, and R2 represents H or COOH.

[0024] Surprisingly, it was found that treatment with the well-known cosmetic ingredients of the carnosine class, particularly L-carnosine, in an amount ranging from about 0.01 wt % to about 5 wt %, preferably from about 0.1 wt % to about 2.5 wt %, can counteract the effects of solar simulated radiation (SSR) on PTGS2 gene expression, thereby reducing the expression level of the gene. Also at the protein level, the examples demonstrate the induction of PTGS2 after SSR exposure and the protective effect of L-carnosine treatment in reducing PTGS2 protein levels in human skin. Therefore, carnosine, particularly L-carnosine, is an effective agent for preventing, alleviating and / or treating human skin disorders, such as inflammation, aging and skin cancer, and related functional disorders, such as fever and pain.

[0025] Carnosine compounds

[0026] Carnosine is essentially a known compound, which can be obtained by conventional methods of organic chemistry. Preferably, these are the substance groups formed by carnosine, L-carnosine, D-carnosine, D / L-carnosine, anserine, D-anserine, L-anserine and L-anserine*HNO3 and mixtures thereof. According to the invention, the salts of the compounds of formula (I) are preferably understood as salts of the compounds of formula (I) with inorganic acids, particularly preferably salts of formula (II):

[0027]

[0028] wherein n is 1, 2 or 3, A is HCl or HNO3, R1 is H or CH3, and R2 is H or COOH. Preferably, carnosine is L-carnosine, a dipeptide composed of β-alanine and histidine.

[0029] Cosmetic preparations

[0030] In a preferred embodiment, the carnosine compound is applied to human skin as a component of a cosmetic skin or sunscreen preparation, such as a cream, lotion or spray. The content of the carnosine compound in the cosmetic preparation is about 0.01 to about 5% by weight, preferably about 0.1 to about 2.5% by weight, based on the preparation.

[0031] These preparations may include anti-dandruff agents, anti-irritants, anti-irritants, antioxidants, astringents, antiperspirants, bactericides, antistatic agents, binders, buffers, carriers, chelating agents, cell stimulants, cleansers, care agents, deodorants, antiperspirants, softeners, emulsifiers, enzymes, essential oils, fibers, film formers, color fixatives, foam formers, foam stabilizers, defoamers, foam boosters, gelling agents, gel formers, hair care agents, hair fixatives, hair straighteners, moisturizers, wetting agents, moisturizers, bleaching agents, strengthening agents, stain repellents, optical brighteners, impregnation agents, stain repellents, friction reducers, lubricants, moisturizing creams, ointments. , sunscreens, plasticizers, covering agents, glazing agents, glossing agents, polymers, powders, proteins, re-oiling agents, abrasives, silicones, hair growth agents, coolants, skin coolants, warming agents, skin warming agents, stabilizers, UV absorbers, UV filters, detergents, thickeners, vitamins, oils, waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, α-hydroxy acids, polyhydroxy fatty acids, liquidizers, dyes, color protection agents, pigments, aromatic substances, polyols, surfactants, electrolytes, organic solvents or silicone derivatives, etc. as additional auxiliaries and additives.

[0032] Preferably, the preparation also contains at least one, more preferably two, three, four or more primary and / or secondary sun protection factors, such as UVA and UVB filters and antioxidants (other than carnosine).

[0033] Surfactants

[0034] Preferred auxiliaries and additives are anionic and / or amphoteric or zwitterionic surfactants. Nonionic and cationic surfactants may also be present in the composition. Suitable examples are mentioned in the paragraph relating to emulsifiers.

[0035] Typical examples of anionic and zwitterionic surfactants include: almond amidopropylamine oxide, almond amidopropyl betaine, aminopropyl lauryl glutamine, ammonium C12-15 alkyl sulfate, ammonium C12-16 alkyl sulfate, ammonium capryl sulfate, ammonium monococoglyceryl sulfate, ammonium coconut sulfate, ammonium cocoyl isethionate, ammonium cocoyl sarcosinate, ammonium C12-15 alkylene sulfate, ammonium C9-10 perfluoroalkyl sulfonate, ammonium dinonyl sulfosuccinate, ammonium dodecylbenzene sulfonate, ammonium isostearate, ammonium laureth-6 carboxylate, ammonium laureth-8 carboxylate, ammonium laureth sulfate, ammonium laureth-5 sulfate, ammonium laureth-7 sulfate, ammonium laureth-9 sulfate, ammonium octanol ... Ammonium laureth-12 sulfate, ammonium lauroyl sarcosinate, ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myristyl sulfate, ammonium myristyl sulfate, ammonium nonylphenol polyether-4 sulfate, ammonium nonylphenol polyether-30 sulfate, ammonium oleate, ammonium palm kernel alcohol sulfate, ammonium stearate, ammonium tall oil acid, isostearyl hydrolyzed collagen AMPD salt, rosin (acyl) hydrolyzed collagen AMPD salt, isostearyl hydrolyzed collagen AMP salt, isostearyl hydrolyzed keratin AMP salt, isostearyl hydrolyzed soy protein AMP salt, isostearyl hydrolyzed wheat protein AMP salt, wild apricot oleamidopropyl betaine, arachidic acid, hexyldecyl phosphate arginine salt, avocado oleamidopropyl betaine, avocado oil glyceryl polyether-8 esters, babassu Seed oil acid, babassu amidopropylamine oxide, babassu amidopropyl betaine, beeswax acid, behenamidopropyl betaine, behenamine oxide, beheneth-25, beheneth-30, behenic acid, behenyl betaine, bis-butyl dimethicone polyglyceryl-3, butylphenol polyether-5 carboxylic acid, butylphenol polyether-19 carboxylic acid, butyldimethyl (hydroxypropyl butyl glucoside) ammonium chloride, butyldimethyl (hydroxypropyl lauryl glucoside) ammonium chloride, butyl glucoside, butyl glucoside decanoate, butyl glucoside hydroxypropyltrimonium chloride, butyl caprylate, C18-36 acid, C20-40 acid, C30-50 acid, C16-22 acid amide MEA, calcium dodecylbenzenesulfonate, calcium lauroyl taurate, C 9-16 Alkane / Cycloalkane, C10-14 Alkylbenzenesulfonic Acid, C12-14 Alkyl Di(Aminoethyl)Glycine HCl, C9-15 Alkyl Phosphate, Candida / Glucose / Rapeseed Methyl Ester Ferment, Canola Amidopropyl Betaine, Capric Acid, Caproic Acid, Caproyl Ethyl Glucoside, Caprylyl / Caprylamidopropyl Betaine, Capryleth-4 Carboxylic Acid, Capryleth-6 Carboxylic Acid, Capryleth-9 Carboxylic Acid, Caprylic Acid, Capryloyl Collagen Amino Acids, Capryloyl Glycine, Capryloyl Hydrolyzed Collagen, Capryloyl Hydrolyzed Keratin, Capryloyl Keratin Amino Acids, Capryloyl Silk Amino Acids, Capryl / Decyl Glucoside, Capryl / Decyl Wheat Bran / Straw Glycosides, Capryl Glucoside, Caprylyl Glyceryl Ether, Capryl Pyrrolidone, Carnitine, Ceteareth-20,Ceteareth-23, Ceteareth-24, Ceteareth-25, Ceteareth-27, Ceteareth-28, Ceteareth-29, Ceteareth-30, Ceteareth-33, Ceteareth-34, Ceteareth-40, Ceteareth-50, Ceteareth-55, Ceteareth-60, Ceteareth-80, Ceteareth-100, Ceteareth-25 Carboxylic Acid, Ceteareth-2 Phosphate, Ceteareth-4 Phosphate Acid, Ceteareth-5 Phosphate, Ceteareth-10 Phosphate, Ceteth-20, Ceteth-23, Ceteth-24, Ceteth-25, Ceteth-30, Ceteth-40, Ceteth-45, Ceteth-150, Ceteth-8 Phosphate, Ceteth-10 Phosphate, Ceteth-20 Phosphate, Ceteth-22, Ceteth-24, Ceteth-25, Ceteth-30, Cetyl Betaine, Chrysanthemum Sinense flower extract, C12-14 hydroxyalkyl hydroxyethyl beta-alanine, C12-14 hydroxyalkyl hydroxyethyl sarcosine, cocamidoethyl betaine, cocamidopropylamine oxide, cocamidopropyl betainamide MEA chloride, cocamidopropyl betaine, cocamidopropyl hydroxysultaine, cocamine oxide, cocoaminobutyric acid, cocoaminopropionic acid, coceth-7 carboxylic acid, coceth-4 glucoside, cocoamphopropionic acid, cocobeth-4 glucoside, cocoamphopropionic acid, cocobeth-betaine amidoamphopropionate, cocobetaine, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, coco-glucoside, coco-glucoside hydroxypropyltrimonium chloride, coco-hydroxysultaine, cocomorpholine oxide, cocoic acid, cocoglyceryl polyether-8 Esters, cocoyl / oleamidopropyl betaine, cocoyl-sulfobetaine, (coconut oil / sunflower seed oil) amidopropyl betaine, cocoyl choline methyl sulfate, cocoyl glutamic acid, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, cocoyl hydrolyzed oat protein, cocoyl hydrolyzed rice protein, cocoyl hydrolyzed silk, cocoyl hydrolyzed soy protein, cocoyl hydrolyzed wheat protein, cocoyl sarcosine, corn oil acid, cotton Seed oil acid, cottonseed oil glyceryl polyether-8 esters, C10-16 parathion-1, C10-16 parathion-2, C11-13 parathion-6, C11-13 parathion-9, C11-13 parathion-10, C11-15 parathion-30, C11-15 parathion-40, C12-13 parathion-1, C12-13 parathion-23,C12-14 Pareth-5, C12-14 Pareth-9, C13-15 Pareth-21, C14-15 Pareth-8, C20-22 Pareth-30, C20-40 Pareth-40, C20-40 Pareth-95, C22-24 Pareth-33, C30-50 Pareth-40, C9-11 Pareth-6 Carboxylic Acid, C9-11 Pareth-8 Carboxylic Acid, C11-15 Pareth-7 carboxylic acid, C12-13 pareth-5 carboxylic acid, C12-13 pareth-7 carboxylic acid, C12-13 pareth-8 carboxylic acid, C12-13 pareth-12 carboxylic acid, C12-15 pareth-7 carboxylic acid, C12-15 pareth-8 carboxylic acid, C12-15 pareth-12 carboxylic acid, C14-15 pareth-8 carboxylic acid, C6-10 pareth-4 phosphate, C12-13 pareth-2 phosphate, C12-13 C12-15 Pareth-6 Phosphate, C12-15 Pareth-8 Phosphate, C12-15 Pareth-10 Phosphate, C12-16 Pareth-6 Phosphate, C4-18 Perfluoroalkyl Ethyl Mercaptopropyl Trimethylammonium Chloride, Cocoamidopropyl Betaine, C12-13 Alcohol Sulfate DEA, C12-15 Alcohol Sulfate DEA, Ceteareth-2 Phosphate DEA, Cetyl Sulfate DEA, Cocoyl DEA amphoteric dipropionate, DEA C12-13 alkane polyether-3 sulfate, DEA cyclopentyl oleate, DEA dodecylbenzene sulfonate, DEA isostearate, DEA laureth sulfate, DEA lauryl sulfate, DEA linoleate, DEA myristyl methyl sulfonate, DEA myristyl ether sulfate, DEA myristate, DEA myristyl sulfate, DEA oleth-5 phosphate, DEA oleth-20 phosphate, DEA PG-oleate, Deceth-7 carboxylic acid, Deceth-7 glucoside, Deceth-9 phosphate, Decylamine oxide, Decyl betaine, Decyl glucoside, Decyltetradeceth-30, Decyltetradeceth-2 oxide, Lauramide-MEA diammonium sulfosuccinate, Laureth-2 diammonium sulfosuccinate, Oleamido PEG-2 diammonium sulfosuccinate, Dibutoxymethane, Di-C12-15 Pareth-2 phosphate, Di C12-15 pareth-4 phosphate, di-C12-15 pareth-6 phosphate, di-C12-15 pareth-8 phosphate, di-C12-15 pareth-10 phosphate, didoyl butane tetracarboxylate, laureth sulfate diethylamine salt, sodium diethylhexyl sulfosuccinate, di(hydroxyethyl) C8-10 alkoxypropylamine oxide, di(hydroxyethyl) C9-11 alkoxypropylamine oxide,Di(hydroxyethyl) C12-15 alkoxypropylamine oxide, di(hydroxyethyl) cocamine oxide, di(hydroxyethyl) laurylamine oxide, di(hydroxyethyl) stearamine oxide, di(hydroxyethyl) tallowamine oxide, dimethicone PEG-7 phosphate, dimethicone PEG-10 phosphate, dimethicone PEG / PPG-7 / 4 phosphate, dimethicone PEG / PPG-12 / 4 phosphate, dimethicone / polyglyceryl-3 crosspolymer, dimethicone propyl PG-betaine, dimyristyl phosphate, dioleamide ethyl hydroxyethyl Methylammonium methylsulfate, hydrogenated coconut oil DIPA salt, lanolin acid DIPA salt, myristic acid DIPA salt, dipotassium capryloyl glutamate, dipotassium lauryl sulfosuccinate, dipotassium undecylenyl glutamate, disodium babassu oleamido MEA-sulfosuccinate, disodium capryloylamphodiacetate, disodium capryloylamphodipropionate, disodium capryloylamphodiacetate, disodium capryloylamphodipropionate, disodium capryloyl glutamate, disodium cetearyl sulfosuccinate, disodium cetyl phenyl ether disulfonate, disodium cetyl alcohol sulfosuccinate, disodium cocamido MEA-sulfosuccinate, cocamido MIPA Disodium PEG-4 Sulfosuccinate, Disodium Cocoamido MIPA-Sulfosuccinate, Disodium Cocoamido PEG-3 Sulfosuccinate, Disodium Cocoeth-3 Sulfosuccinate, Disodium Cocoamphocarboxyethyl Hydroxypropyl Sulfonate, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate, Disodium Coco-glucoside Sulfosuccinate, Disodium Coco-sulfosuccinate, Disodium Cocoyl Butyl Gluceth-10 Sulfosuccinate, Disodium Cocoyl Glutamate, Disodium C12-14 Pareth-1 Sulfosuccinate, Disodium C12-14 Pareth-2 Sulfosuccinate, Disodium C12-15 Pareth Sulfosuccinate, C12-14 Secondary Chain Disodium C12-14 Sec-Pareth-5 Sulfosuccinate, Disodium C12-14 Sec-Pareth-7 Sulfosuccinate, Disodium C12-14 Sec-Pareth-9 Sulfosuccinate, Disodium C12-14 Sec-Pareth-12 Sulfosuccinate, Disodium Deceth-5 Sulfosuccinate, Disodium Deceth-6 Sulfosuccinate, Disodium Decyl Phenyl Ether Disulfonate, Disodium Dihydroxyethyl Sulfosuccinylddecylenate, Disodium Cocoyl Ethylenediamine PEG-15 Disulfate, Disodium Hydrogenated Cottonseed Glycerides Sulfosuccinate, Disodium Hydrogenated Tallowyl Glutamate, Disodium Hydroxydecyl Sorbitan Citrate, Disodium Isodecyl Sulfosuccinate, Isostearamide M EA-Disodium Sulfosuccinate, Isostearamide MIPA-Disodium Sulfosuccinate, Isostearylamphodiacetate Disodium, Isostearylamphodipropionate Disodium, Isostearyl Sulfosuccinate Disodium, Lanolin Ether-5 Sulfosuccinate Disodium, Lauramide MEA-Sulfosuccinate Disodium,Disodium lauroyl MIPA glycol sulfosuccinate, disodium lauroyl PEG-2 sulfosuccinate, disodium lauroyl PEG-5 sulfosuccinate, disodium laureth-5 carboxyamphodiacetate, disodium laureth-7 citrate, disodium laureth sulfosuccinate, disodium laureth-6 sulfosuccinate, disodium laureth-9 sulfosuccinate, disodium laureth-12 sulfosuccinate, disodium laurimidobishydroxypropyl sulfonate, disodium laurimidodiacetate, disodium laurimidodipropionate, disodium laurimidodipropionate tocopheryl phosphate, disodium lauroamphodiacetate, disodium lauroamphodipropionate, disodium N-lauroyl aspartate, lauroyl glutamate Disodium lauryl phenyl ether disulfonate, diammonium lauryl sulfosuccinate, disodium myristamide MEA-sulfosuccinate, disodium nonylphenol polyether-10 sulfosuccinate, disodium oleamide MEA sulfosuccinate, disodium oleamide MIPA sulfosuccinate, disodium oleamide PEG-2 sulfosuccinate, disodium oleoamphodipropionate, disodium oleeth-3 sulfosuccinate, disodium oleyl phosphate, disodium oleyl sulfosuccinate, disodium palmitamide PEG-2 sulfosuccinate, disodium palmitamide PEG-2 sulfosuccinate, disodium palmitamide PEG-4 sulfosuccinate, disodium PEG-12 polydimethylsiloxane sulfosuccinate, PEG-8 palmitic acid Glycerides Disodium sulfosuccinate, PPG-2-isodecyl polyether-7 sodium carboxyamphodiacetate, disodium ricinoleamide MEA sulfosuccinate, disodium sitosterol polyether-14 sulfosuccinate, disodium soybean oleylamphodiacetate, disodium stearamide MEA-sulfosuccinate, disodium stearimidodipropionate, disodium stearamidodiacetate, disodium stearoyl glutamate, disodium sulfosuccinic acid monoacyl stearylamine, disodium stearyl alcohol sulfosuccinate, disodium 2-sulfolaurate, disodium 2-sulfopalmitate, disodium tallowamide MEA sulfosuccinate, disodium tallowamide MEA sulfosuccinate, disodium tallowamidodiacetate, disodium tallowimidodipropionate, disodium sulfosuccinic acid monoacyl tallowamine, tridecyl alcohol Disodium sulfosuccinate, disodium undecylenamide MEA sulfosuccinate, disodium undecylenamide PEG-2 sulfosuccinate, disodium undecylenyl glutamate, disodium monowheat germ oleoyl MEA sulfosuccinate, disodium monowheat germ oleoyl PEG-2 sulfosuccinate, disodium wheat germ oleoyl amphoteric acid, cocamide diacetate di-TEA salt, oleamide PEG-2 sulfosuccinate di-TEA salt, palmitoyl aspartate di-TEA salt, sodium tridecyl sulfosuccinate, dodecylbenzenesulfonic acid, erucamidopropyl hydroxysulfobetaine, ethylhexyl alcohol polyether-3 carboxylic acid, ethyl PEG-15 cocamide sulfate, caprylyl glyceryl ether, hexyl capric acid, hydrogenated coconut acid, hydrogenated lanolin alcohol polyether-25,Hydrogenated menhaden oil fatty acid, hydrogenated palmitoleic acid, hydrogenated palm kernel oil amine oxide, hydrogenated tallow acid, hydrogenated tallow amine oxide, hydrogenated tallow betaine, hydrogenated tallow alcohol polyether-25, hydrogenated tallow acyl glutamate, hydrogenated candida extract, hydroxycetyl alcohol polyether-60, hydroxyethyl acetoxymethyl ammonium PG-polydimethylsiloxane, laureth sulfate hydroxyethyl butylamine salt, hydroxyethyl carboxymethyl cocamidopropylamine, hydroxyethyl hydroxypropyl C12-15 alkoxypropylamine oxide, hydroxylauryl / hydroxymyristyl betaine, hydroxystearic acid, hydroxysuccinimide C10-40 isoalkanoate, hydroxysuccinimide C21-22 isoalkanoate, hydroxysultaine, IPDI / PEG-15 soybean oil amine oxide copolymer, IPDI / PEG-15 soybean oil amine ethanol methyl sulfate copolymer, IPDI / PEG-15 soybean oil glycine ester copolymer, Isoceteth-30, Isolaureth-4 phosphate, Isopolyglyceryl-3 polydimethylsiloxane, Isopolyglyceryl-3 polydimethylsiloxane, Isopropylamine lanolin acid ester, Isopropylamine dodecylbenzenesulfonate, Isostearamidopropylamine oxide, Isostearamidopropyl betaine, Isostearamidopropyl morpholine oxide, Isosteareth-8, Isosteareth-16, Isosteareth-22, Isosteareth-25, Isosteareth-50, Isostearic acid, Isostearyl hydrolyzed collagen, Jojoba oil PEG-150 esters, Jojoba wax PEG-80 esters, PEG-120 esters of joba wax, lanolin alcohol polyether-20, lanolin alcohol polyether-25, lanolin alcohol polyether-40, lanolin alcohol polyether-50, lanolin alcohol polyether-60, lanolin alcohol polyether-75, lanolin acid, lauramide propylamine oxide, lauramide propyl betaine, lauramide propyl hydroxysulfobetaine, lauramine oxide, lauryl aminopropionic acid, lauryl dimethyl hydroxypropyl decyl glucoside ammonium chloride, lauryl dimethyl lauryl glucoside hydroxypropyl ammonium chloride, laureth-16, laureth-20, laureth-21, laureth-23, laureth-25, laureth-30, laureth-38, laureth-40, laureth-3 carboxylic acid, lauryl Alcohol polyether-4 carboxylic acid, laureth-5 carboxylic acid, laureth-6 carboxylic acid, laureth-8 carboxylic acid, laureth-10 carboxylic acid, laureth-11 carboxylic acid, laureth-12 carboxylic acid, laureth-13 carboxylic acid, laureth-14 carboxylic acid, laureth-17 carboxylic acid, laureth-6 citrate, laureth-7 citrate, laureth-1 phosphate, laureth-2 phosphate, laureth-3 phosphate, laureth-4 phosphate, laureth-7 phosphate, laureth-8 phosphate, laureth-7 tartrate, lauric acid, lauriminodipropylene glycol, lauriminodipropionic acid, lauroylamphodipropionic acid, lauroyl β-aminopropionic acid,Lauroyl collagen amino acid, lauroyl ethyltrimonium methosulfate, lauroyl hydrolyzed collagen, lauroyl hydrolyzed elastin, lauroyl methyl glucamide, lauroyl sarcosine, lauroyl silk amino acid, lauryl betaine, lauryl dimethicone / polyglyceryl-3 crosspolymer, lauryl dimethyl hydroxypropyl cocoyl glucoside ammonium chloride, lauryl glucoside, lauryl glucoside hydroxypropyltrimonium chloride, lauryl glycol hydroxypropyl ether, lauryl hydroxysulfobetaine, lauryl malic acid amide, lauryl methyl glucosamine, (laury / myristic) glycol hydroxypropyl ether, (laury / myristic) wheat bran / straw glycosides, lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethicone, lauryl pyrrolidone, lauryl dimethyl Sultaine, Linoleic Acid, Linolenic Acid, Linolenic Acid, Lysine Cocoate, Macadamia Seed Oil Glycereth-8 Esters, Magnesium Cocoyl Sulfate, Magnesium Cocoyl Sulfate, Magnesium Isododecylphenyl Sulfonate, Magnesium Laureth-11 Carboxylate, Magnesium Laureth Sulfate, Magnesium Laureth-5 Sulfate, Magnesium Laureth-8 Sulfate, Magnesium Laureth-16 Sulfate, Magnesium Laureth-3 Sulfosuccinate, Magnesium Lauryl Hydroxypropyl Sulfonate, Magnesium Lauryl Sulfate, Magnesium Methyl Cocoyl Taurate, Magnesium Myristyl Sulfate, Magnesium Oleth Sulfate, Magnesium Cocoyl Sulfate / TEA, Manigold Root Glacial Mud, Coconut Oil MEA Salt, Laureth-6 Carboxylate MEA Salt, Laureth Sulfate MEA Salt, Moon Lauryl sulfate MEA salt, PPG-6-laureth-7 carboxylic acid MEA salt, PPG-8-stearyl alcohol polyether-7 carboxylic acid MEA salt, undecylenic acid MEA salt, meroxapol 108, meroxapol 174, meroxapol 178, meroxapol 254, meroxapol 255, meroxapol 258, meroxapol 314, methoxy PEG-450 amidoglutaryl succinamide, methoxy PEG-450 amidohydroxysuccinimide succinate, methoxy PEG-450 maleimide, methylmorpholine oxide, milk amide propylamine oxide, milk amide propyl betaine, mink oil amide propylamine oxide, mink oil amide propyl betaine, C12-15 alkyl alcohol polyether sulfate MIPA salt, dodeca MIPA salt of alkylbenzene sulfonate, MIPA salt of lauryl alcohol polyether sulfate, MIPA salt of lauryl alcohol sulfate, mixed isopropanolamine lanolin acid salt, mixed isopropanolamine lauryl sulfate, mixed isopropanolamine myristate, morpholine oleate, morpholine stearate, myristeth-3 carboxylic acid, myristeth-5 carboxylic acid, myristyl benzyl dimethyl ammonium chloride, myristamidopropylamine oxide, myristamidopropyl betaine, myristamidopropyl dimethylamine phosphate, myristamidopropyl hydroxysulfobetaine, myristamidopropyl PG-dimethyl ammonium chloride phosphate, myristamine oxide, myristyl aminopropionic acid, myristic acid, myristoyl ethyltrimethyl ammonium methyl sulfate, myristoyl glutamic acid, myristoyl hydrolyzed collagen,Myristoyl Sarcosine, Myristyl Betaine, Myristyl / Cetylamine Oxide, Myristyl Dimethyl Hydroxypropyl Cocoyl Glucoside Ammonium Chloride, Myristyl Glucoside, Myristyl Alcohol Phosphate, Nonylphenol Eth-20, Nonylphenol Eth-23, Nonylphenol Eth-25, Nonylphenol Eth-30, Nonylphenol Eth-35, Nonylphenol Eth-40, Nonylphenol Eth-44, Nonylphenol Eth-50, Nonylphenol Eth-100, Nonylphenol Eth-120, Nonylphenol Eth-5 Carboxylic Acid, Nonylphenol Eth-8 Carboxylic Acid, Nonylphenol Eth-10 Carboxylic Acid, Nonylphenol Eth-3 Phosphate, Nonylphenol Eth-4 Phosphate, Nonylphenol Eth-6 Phosphate, Nonylphenol Eth-9 Phosphate, Nonylphenol Eth-10 Phosphate, Dinonylphenol Polyether-30, dinonylphenol polyether-49, dinonylphenol polyether-100, dinonylphenol polyether-150, dinonylphenol polyether-7 phosphate, dinonylphenol polyether-8 phosphate, dinonylphenol polyether-9 phosphate, dinonylphenol polyether-10 phosphate, dinonylphenol polyether-11 phosphate, dinonylphenol polyether-15 phosphate, dinonylphenol polyether-24 phosphate, oat oil amidopropyl betaine, octylphenol polyether-16, octylphenol polyether-25, octylphenol polyether-30, octylphenol polyether-33, octylphenol polyether-40, octylphenol polyether-70, octylphenol polyether-20 carboxylic acid, octyldodecyl polyether-20, octyldodecyl polyether-25, octyldodecyl polyether-30, oleamidopropylamine oxide, oleamide Propyl Betaine, Oleamidopropyl (Hydroxysulfonyl)propyl Dimethyl Ammonium, Oleamine Oxide, Oleic Acid, Oleyl Hydrolyzed Collagen, Oleyl Sarcosine, Oleth-20, Oleth-23, Oleth-24, Oleth-25, Oleth-30, Oleth-35, Oleth-40, Oleth-44, Oleth-50, Oleth-3 Carboxylic Acid, Oleth-6 Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleyl Betaine, Oleamidopropyl Betaine, Oleic Acid, Oleoyl Hydrolyzed Wheat Protein, Ophiopogon Japonicus Extract Stearate, Ozonoxigenated Oleth-10, Ozonoxigenated PEG-10 Oleate, Ozonoxigenated PEG-14 Oleate, Ozonoxigenated Polysorbate 8 0, Palmitoleic acid, palmitamidopropyl betaine, palmitoleyl alcohol polyether-2 phosphate, palmitamidopropylamine oxide, palmitamidopropyl betaine, palmitamine oxide, palmitic acid, palmitoyl collagen amino acids, palmitoyl glycine, palmitoyl hydrolyzed collagen, palmitoyl hydrolyzed milk protein, palmitoyl hydrolyzed wheat protein, palmitoyl keratin amino acids, palmitoyl oligopeptide, palmitoyl silk amino acids, palm kernel oleic acid, palm kernel oleamidopropyl betaine, peach kernel oil glyceryl polyether-8 esters, arachidic acid, PEG-10 castor oil, PEG-40 castor oil, PEG-44 castor oil, PEG-50 castor oil, PEG-54 castor oil, PEG-55 castor oil, PEG-60 castor oil, PEG-80 castor oil,PEG-100 castor oil, PEG-200 castor oil, PEG-11 cocamide, PEG-6 cocamide phosphate, PEG-4 cocamide, PEG-8 cocamide, PEG-12 cocamide, PEG-150 dibehenate, PEG-90 diisostearate, PEG-75 dilaurate, PEG-150 dilaurate, PEG-75 dioleate, PEG-150 dioleate, PEG-75 distearate, PEG-120 distearate, PEG-150 distearate, PEG-175 distearate, PEG-190 distearate, PEG-250 distearate, PEG-30 glyceryl cocoate, PEG-40 glyceryl coconut oil Acid PEG-78 Glyceryl Cocoate, PEG-80 Glyceryl Cocoate, PEG-30 Glyceryl Isostearate, PEG-40 Glyceryl Isostearate, PEG-50 Glyceryl Isostearate, PEG-60 Glyceryl Isostearate, PEG-90 Glyceryl Isostearate, PEG-23 Glyceryl Laurate, PEG-30 Glyceryl Laurate, PEG-25 Glyceryl Oleate, PEG-30 Glyceryl Oleate, PEG-30 Glyceryl Soybean Oleate, PEG-25 Glyceryl Stearate, PEG-30 Glyceryl Stearate, PEG-40 Glyceryl Stearate, PEG-120 Glyceryl Stearate, PEG-200 Glyceryl Stearate, PEG-28 Glyceryl Tallowate, PEG- PEG-80 glyceryl tallow ester, PEG-82 glyceryl tallow ester, PEG-130 glyceryl tallow ester, PEG-200 glyceryl tallow ester, PEG-45 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-54 hydrogenated castor oil, PEG-55 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-100 hydrogenated castor oil, PEG-200 hydrogenated castor oil, PEG-30 hydrogenated lanolin, PEG-70 hydrogenated lanolin, PEG-50 hydrogenated palmitamide, PEG-2 isostearate, PEG-3 isostearate, PEG-4 isostearate, PEG-6 isostearate, PEG-8 isostearate, PEG -10 Isostearate, PEG-12 Isostearate, PEG-20 Isostearate, PEG-30 Isostearate, PEG-40 Isostearate, PEG-26 Jojoba Acid, PEG-40 Jojoba Acid, PEG-15 Jojoba Alcohol, PEG-26 Jojoba Alcohol, PEG-40 Jojoba Alcohol, PEG-35 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-55 Lanolin, PEG-60 Lanolin, PEG-70 Lanolin, PEG-75 Lanolin, PEG-85 Lanolin, PEG-100 Lanolin, PEG-150 Lanolin, PEG-75 Lanolin Oil, PEG-2 Lauramide, PEG-3 Lauramine Oxide,PEG-20 laurate, PEG-32 laurate, PEG-75 laurate, PEG-150 laurate, PEG-70 mango seed oil glycerides, PEG-20 mannide laurate, PEG-8 methyl ether polydimethylsiloxane, PEG-120 methyl glucose dioleate, PEG-80 methyl glucose laurate, PEG-120 methyl glucose trioleate, PEG-4 montanate, PEG-30 oleamine, PEG-20 oleate, PEG-23 oleate, PEG-32 oleate, PEG-36 oleate, PEG-75 oleate, PEG-150 oleate, PEG-20 palmitate, PEG-150 polyglyceryl-2 tristearate, PE PEG / PPG-28 / 21 ester polydimethylsiloxane, PEG / PPG-24 / 18 butyl ether polydimethylsiloxane, PEG / PPG-3 / 17 copolymer, PEG / PPG-5 / 35 copolymer, PEG / PPG-8 / 55 copolymer, PEG / PPG-10 / 30 copolymer, PEG / PPG-10 / 65 copolymer, PEG / PPG-12 / 35 copolymer, PEG / PPG-16 / 17 copolymer, PEG / PPG-20 / 9 copolymer, PEG / PPG-20 / 20 copolymer, PEG / PPG-20 / 60 copolymer, PEG / PPG-20 / 65 copolymer, PEG / PPG-22 / 25 copolymer, PEG / PPG PG-28 / 30 copolymer, PEG / PPG-30-35 copolymer, PEG / PPG-30 / 55 copolymer, PEG / PPG-35 / 40 copolymer, PEG / PPG-50 / 40 copolymer, PEG / PPG-150 / 35 copolymer, PEG / PPG-160 / 30 copolymer, PEG / PPG-190 / 60 copolymer, PEG / PPG-200 / 40 copolymer, PEG / PPG-300 / 55 copolymer, PEG / PPG-20 / 22 methyl ether polydimethylsiloxane, PEG-26-PPG-30 phosphate, PEG / PPG-4 / 2 propyl heptyl ether, PEG / PPG-6 / 2 propyl heptyl ether, PEG-7 / PPG- PG-2 Propyl Heptyl Ether, PEG / PPG-8 / 2 Propyl Heptyl Ether, PEG / PPG-10 / 2 Propyl Heptyl Ether, PEG / PPG-14 / 2 Propyl Heptyl Ether, PEG / PPG-40 / 2 Propyl Heptyl Ether, PEG / PPG-10 / 2 Ricinoleate, PEG / PPG-32 / 3 Ricinoleate, PEG-55 Propylene Glycol Oleate, PEG-25 Propylene Glycol Stearate, PEG-75 Propylene Glycol Stearate, PEG-120 Propylene Glycol Stearate, PEG-5 Rapeseed Sterol, PEG-10 Rapeseed Sterol, PEG-40 Ricinoleamide, PEG-75 Shea Butter Glycerides, PEG-75 Sorbitan Cocoate,PEG-20 sorbitan isostearate, PEG-40 sorbitan lanolinate, PEG-75 sorbitan lanolinate, PEG-10 sorbitan laurate, PEG-40 sorbitan laurate, PEG-44 sorbitan laurate, PEG-75 sorbitan laurate, PEG-80 sorbitan laurate, PEG-20 sorbitan oleate, PEG-80 sorbitan palmitate, PEG-40 sorbitan stearate, PEG-60 sorbitan stearate, PEG-160 sorbitan triisostearate, PEG-40 soybean sterol, PEG-2 stearamidocarboxylic acid, PEG-9 stearyl Amine carboxylic acid, PEG-20 stearate, PEG-23 stearate, PEG-25 stearate, PEG-30 stearate, PEG-32 stearate, PEG-35 stearate, PEG-36 stearate, PEG-40 stearate, PEG-45 stearate, PEG-50 stearate, PEG-55 Stearate, PEG-75 stearate, PEG-90 stearate, PEG-100 stearate, PEG-120 stearate, PEG-150 stearate, PEG-45 stearate phosphate, PEG-20 tallate, PEG-50 tallow amide, PEG-2 tallow amide DEA, PEG-20 tallow Acid esters, PEG-66 trihydroxystearin, PEG-200 trihydroxystearin, PEG-60 camellia ester glyceride, nonanoic acid, pentadecylphenol polyether-200, phenol polyether-6 phosphate, poloxamer 105, poloxamer 108, poloxamer 182, poloxamer 183, poloxamer 184, poloxamer 188, poloxamer 217, poloxamer 234, poloxamer 235, poloxamer 237, poloxamer 238, poloxamer 288, poloxamer 334, poloxamer 335, poloxamer 338, poloxamer 908, poloxamer 1508, polydimethylsiloxy PEG / PPG-24 / 19 butyl ether silsesquioxane, polydimethylsiloxy Oxy PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-6 Caprate, Polyglyceryl-10 Dilaurate, Polyglyceryl-20 Heptacaprylate, Polyglyceryl-20 Hexacaprylate, Polyglyceryl-2 Laureth, Polyglyceryl-10 Laureth, Polyglyceryl-20 Octaisononanoate, Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Pentacaprylate, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Polyglyceryl-6 Tetracaprylate, Polyglyceryl-10 Tetralaurate, Polyglyceryl-6 Tricaprylate, Polyglyceryl-10 Trilaurate, Polyquaternium-77, Polyquaternium-78, Polyquaternium-79, Polyquaternium-80, Polyquaternium-81, Polyquaternium-82, Pomaderris Kumerahou Flower / Leaf Extract, Poria Cocos Extract,Potassium abietic acid hydrolyzed collagen, potassium babassu oleate, potassium behenate, potassium C9-15 alcohol phosphate, potassium C11-15 alcohol phosphate, potassium C12-13 alcohol phosphate, potassium C12-14 alcohol phosphate, potassium caprate, potassium capryloyl glutamate, potassium capryloyl hydrolyzed rice protein, potassium ricinoleate, potassium cocoate, potassium cocoyl glutamate, potassium cocoyl glycinate, potassium cocoyl hydrolyzed casein, potassium cocoyl hydrolyzed collagen, potassium cocoyl hydrolyzed corn protein, potassium cocoyl hydrolyzed keratin, potassium cocoyl hydrolyzed oat protein, potassium cocoyl hydrolyzed potato protein, potassium cocoyl hydrolyzed rice bran protein, potassium cocoyl hydrolyzed rice protein, potassium cocoyl hydrolyzed silk, potassium cocoyl hydrolyzed soy protein, potassium cocoyl hydrolyzed wheat protein, potassium cocoyl hydrolyzed yeast protein, cocoyl PCA Potassium, Potassium Cocoyl Sarcosine, Potassium Cocoyl Taurine, Potassium Corn Oleate, Potassium Cyclopropyl Oleate, Potassium Dihydroxyethyl Cocoamine Oxide Phosphate, Potassium Dimethicone PEG-7 Phosphate, Potassium Dodecylbenzenesulfonate, Potassium Hemp Seed Oil, Potassium Hydrogenated Coconut Oil, Potassium Hydrogenated Palm Oleate, Potassium Hydrogenated Tallow, Potassium Hydroxystearate, Potassium Isostearate, Potassium Lanolin Oleate, Potassium Laurate, Potassium Laureth-3 Carboxylate, Potassium Laureth-4 Carboxylate, Potassium Laureth-5 Carboxylate, Potassium Laureth-6 Carboxylate, Potassium Laureth-10 Carboxylate, Potassium Laureth Phosphate, Potassium Lauroyl Collagen Amino Acids, Potassium Lauroyl Glutamate, Potassium Lauroyl Hydrolyzed Collagen, Potassium Lauroyl Hydrolyzed Pea Protein, Potassium Lauroyl Hydrolyzed Soy Protein, Potassium Lauroyl PCA, Laury Potassium acyl pea amino acids, potassium lauroyl sarcosine, potassium lauroyl silk amino acids, potassium lauroyl wheat amino acids, potassium lauryl phosphate, potassium lauryl sulfate, potassium linoleate, potassium metaphosphate, potassium methyl cocoyl taurate, potassium myristate, potassium myristoyl glutamate, potassium myristoyl hydrolyzed collagen, potassium octylphenol polyether-12 phosphate, potassium oleate, potassium oleoyl hydrolyzed collagen, potassium olivetate, potassium olivetate hydrolyzed oat protein, potassium olivetate hydrolyzed wheat protein, potassium olivetate / lauroyl wheat amino acids, potassium olivetate PCA, potassium palmitoleate, potassium palmitate, potassium palmitoyl hydrolyzed corn protein, potassium palmitoyl hydrolyzed oat protein, potassium palmitoyl hydrolyzed rice protein, potassium palmitoyl hydrolyzed sweet almond protein, potassium palmitoyl hydrolyzed wheat protein, palm kernel oleic acid Potassium, Potassium arachidate, Potassium rapeseed oleate, Potassium ricinoleate, Potassium safflower oleate, Potassium soybean oleate, Potassium stearate, Potassium stearoyl hydrolyzed collagen, Potassium tallowate, Potassium taurine, Potassium taurine laurate, Potassium trideceth-3 carboxylate, Potassium trideceth-4 carboxylate, Potassium trideceth-7 carboxylate, Potassium trideceth-15 carboxylate, Potassium trideceth-19 carboxylate, Potassium trideceth-6 phosphate, Potassium trideceth-7 phosphate, Potassium camellia oleate, Potassium undecylenate, Potassium undecylenyl hydrolyzed collagen, Potassium undecylenyl hydrolyzed rice protein, PPG-30-buteth-30, PPG-36-buteth-36, PPG-38-buteth-37, PPG-30-octanol polyether-4 phosphate,PPG-10 cetyl ether phosphate, PPG-2 C9-11 alcohol polyether-8, PPG-1-decyl polyether-5, PPG-3-decyl polyether-2 carboxylic acid, PPG-30-ethylhexyl polyether-4 phosphate, PPG-20-glyceryl polyether-30, PPG-2 hydroxyethyl coco / isostearamide, PPG-2-isodecyl polyether-8, PPG-2-isodecyl polyether-10, PPG-2-isodecyl polyether-18, PPG-2-isodecyl polyether-25, PPG-4-isodecyl polyether-10, propyltrimonium hydrolyzed collagen, quaternium-24, quaternium-52, quaternium-87, rapeseed oleic acid, rice bran acid, rice oil glyceryl polyether-8 esters, ricinoleic acid amidopropyl betaine, ricinoleic acid, ricinoleic alcohol polyether-40, safflower oleic acid, Sapindus Oahuensis Fruit Extract, Saponaria Officinalis Root Powder, Saponins, Potassium Soap, Sodium / Potassium Soap, Soap Base, Potassium Soap Base, Sesame Glycereth-8 Esters, Sesame Amidopropylamine Oxide, Sesame Amidopropyl Betaine, Shea Butter Amidopropyl Betaine, Shea Butter Glycereth-8 Esters, Sodium Arachidate, Sodium Arganampohoacetate, Sodium Murumuru Palm Oleate, Sodium Avocado Oleate, Sodium Babassu Amphoacetate, Sodium Babassu Oleate, Sodium Babassu Sulfate, Sodium Behenate, Sodium diethylene glycol ricinoleyl sulfosuccinate, sodium bis(hydroxyethyl)glycinate cocoyl glucoside cross-polymer, sodium bis(hydroxyethyl)glycinate lauryl glucoside cross-polymer, sodium borage oleamidopropyl PG-dimonium chloride phosphate, sodium butylphenol polyether-12 sulfate, sodium butyl glucoside hydroxypropyl phosphate, sodium C13-17 alkane sulfonate, sodium C14-18 alkane sulfonate, sodium C12-15 alkoxypropyl iminodipropionate, sodium C10-16 alcohol sulfate, sodium C11-15 alkyl sulfate, sodium C12 Sodium C-13 alkyl sulfate, sodium C12-15 alkyl sulfate, sodium C12-18 alkyl sulfate, sodium C16-20 alkyl sulfate, sodium C9-22 secondary alkyl sulfonate, sodium C14-17 secondary alkyl sulfonate, sodium caprate, sodium caprylate, sodium capryloylamphoacetate, sodium capryloylamphohydroxypropyl sulfonate, sodium capryloylamphopropionate, sodium capryloylmethyl taurate, sodium caprylate, sodium capryleth-2 carboxylate, sodium capryleth-9 carboxylate, sodium capryloylamphoacetate, sodium capryloylamphohydroxypropyl sulfonate, sodium capryloylamphopropionate, capryloylglutamate Disodium iodide, Sodium capryloyl hydrolyzed wheat protein, Sodium capryl PG-sulfonate, Sodium capryl sulfonate, Sodium ricinoleate, Sodium ceteareth-13 carboxylate, Sodium cetearyl sulfate, Sodium ceteth-13 carboxylate, Sodium cetyl sulfate, Sodium cocamidopropyl PG-dimonium chloride phosphate, Sodium cocoyl aminopropionate, Sodium cocoether sulfate, Sodium cocoether-30 sulfate, Sodium cocoamphoacetate, Sodium cocoa butter esters, Sodium cocoamphoacetate, Sodium cocoamphohydroxypropyl sulfonate,Sodium Cocoamphopropionate, Sodium Coconut Oil Acid, Sodium Cocoyl / Babassu / Andyraba Sulfate, Sodium Cocoyl / Babassu Sulfate, Sodium Cocoyl Glucoside Hydroxypropyl Phosphate, Sodium Cocoyl Glucoside Hydroxypropyl Sulfonate, Sodium Coco-Glucoside Tartrate, Sodium Cocoyl Glyceryl Ether Sulfonate, Sodium Cocoyl / Hydrogenated Tallow Alcohol Sulfate, Sodium Cocoiminodiacetate, Sodium Coco Monoglyceride Sulfate, Sodium Cocoyl Monoglyceride Sulfonate, Sodium Cocoyl PG-Dimethylammonium Chloride Phosphate, Sodium Cocoyl Sulfate, Sodium Cocoyl Sulfoacetate, Sodium Cocoyl Aminopropionate, Sodium Cocoyl Amino Acids, Sodium Cocoyl Collagen Amino Acids, Sodium Cocoyl Glutamate, Sodium Cocoyl Glutamate, Sodium Cocoyl Glycinate, Sodium Cocoyl / Hydrogenated Tallow Glutamate , Sodium Cocoyl Hydrolyzed Collagen, Sodium Cocoyl Hydrolyzed Keratin, Sodium Cocoyl Hydrolyzed Rice Protein, Sodium Cocoyl Hydrolyzed Silk, Sodium Cocoyl Hydrolyzed Soy Protein, Sodium Cocoyl Hydrolyzed Sweet Almond Protein, Sodium Cocoyl Hydrolyzed Wheat Protein Glutamate, Sodium Cocoyl Hydrolyzed Wheat Protein Glutamate, Sodium Cocoyl Isethionate, Sodium Cocoyl Methylaminopropionate, Sodium Cocoyl Oat Amino Acids, Sodium Cocoyl / Palmitoyl / Sunfloweroyl Glutamate, Sodium Cocoyl Proline, Sodium Cocoyl Sarcosinate, Sodium Cocoyl Taurine, Sodium Cocoyl Threonine, Sodium Cocoyl Wheat Amino Acids, Sodium C12-14 Olefin Sulfonate, Sodium C14-16 Olefin Sulfonate, Sodium C14-18 Olefin Sulfonate, Sodium C16-18 Olefin Sulfonate, Sodium Corn Amphoteric Propionate , Sodium cottonseed oil acyl amphoacetate, Sodium C13-15 pareth-8 butanol phosphate, Sodium C9-11 pareth-6 carboxylate, Sodium C11-15 pareth-7 carboxylate, Sodium C12-13 pareth-5 carboxylate, Sodium C12-13 pareth-8 carboxylate, Sodium C12-13 pareth-12 carboxylate, Sodium C12-15 pareth-6 carboxylate, Sodium C12-15 pareth-7 carboxylate, Sodium C12-15 pareth-8 carboxylate, Sodium C14-15 pareth-8 carboxylate, Sodium C12-14 secondary pareth-8 carboxylate, Sodium C14-15 pareth-PG sulfonate, Sodium C12-13 pareth-2 phosphate, Sodium C13-15 pareth-8 phosphate, C9-15 Sodium C10-15 polyether sulfate, sodium C10-16 polyether-2 sulfate, sodium C12-13 polyether sulfate, sodium C12-15 polyether sulfate, sodium C12-15 polyether sulfate, sodium C12-15 polyether-3 sulfate, sodium C13-15 polyether-3 sulfate, sodium C12-14 secondary polyether-3 sulfate, sodium C12-15 polyether-3 sulfonate, sodium C12-15 polyether-7 sulfonate, sodium C12-15 polyether-15 sulfonate, sodium deceth-2 carboxylate, sodium deceth sulfate, sodium decylbenzene sulfonate, sodium decyl glucoside hydroxypropyl phosphate, sodium decyl glucoside hydroxypropyl sulfonate, sodium di(laureth-7) citrate, sodium di(laureth-10) phosphate,Sodium dilinoleamidopropyl PG-dimonium chloride phosphate, sodium dimer dimer linoleate, sodium dioleth-8 phosphate, sodium dodecylbenzene sulfonate, sodium 2-ethyl sulfolaurate, sodium glyceryl oleate phosphate, sodium grapeseed oleamidopropyl PG-dimonium chloride phosphate, sodium grapeseed oleoylamphoacetate, sodium grapeseed oleoyl acid, sodium hexyl alcohol polyether-4 carboxylate, sodium hydrogenated coconut oil, sodium hydrogenated coconut oil methyl isethionate, sodium hydrogenated palm oleate, sodium hydrogenated tallow acid, sodium hydrogenated tallow glutamate, sodium hydroxylauryldimonium ethyl phosphate, sodium palm kernel hydroxypropyl sulfonate, sodium hydroxypropyl decyl glucoside crosspolymer, sodium hydroxypropyl lauryl glucoside crosspolymer, sulfonic acid Sodium Hydroxypropyl Cocoyl Glucoside Crosspolymer, Sodium Hydroxypropyl Decyl Glucoside Sulfonate Crosspolymer, Sodium Hydroxypropyl Lauryl Glucoside Sulfonate Crosspolymer, Sodium Hydroxystearate, Sodium Isostearate, Sodium Isosteareth-6 Carboxylate, Sodium Isosteareth-11 Carboxylate, Sodium Isostearylamphoacetate, Sodium Isostearylamphopropionate, Sodium N-Isostearyl Methyl Taurate, Sodium Lanolin Sulfate, Sodium Lanolin Acid, Sodium Lardate, Sodium Lauramidodiacetate, Sodium Lauryl Aminopropionate, Sodium Laurate, Sodium Laureth-3 Carboxylate, Sodium Laureth-4 Carboxylate, Sodium Laureth-5 Carboxylate, Sodium Laureth-6 Carboxylate, Sodium Laureth-8 Carboxylate, Sodium Laureth-11 Carboxylate, Sodium Laureth-12 Carboxylate , Sodium Laureth-13 Carboxylate, Sodium Laureth-14 Carboxylate, Sodium Laureth-16 Carboxylate, Sodium Laureth-17 Carboxylate, Sodium Laureth Sulfate, Sodium Laureth-5 Sulfate, Sodium Laureth-7 Sulfate, Sodium Laureth-8 Sulfate, Sodium Laureth-12 Sulfate, Sodium Laureth-40 Sulfate, Sodium Laureth-7 Tartrate, Disodium Lauriminodipropionate, Sodium Lauroamphoacetate, Sodium Lauroamphohydroxypropyl Sulfonate, Sodium Lauroampho PG-Acetate Phosphate, Sodium Lauroamphopropionate, Sodium Lauroyl Aspartate, Sodium Lauroyl Collagen Amino Acids, Sodium Lauroyl Glycine Propionate, Sodium Lauroyl Hydrolyzed Collagen, Sodium Lauroyl Hydrolyzed Silk, Lauroyl Hydroxypropyl Sodium Lauroyl Isethionate, Sodium Lauroyl Methylaminopropionate, Sodium Lauroyl Methyl Isethionate, Sodium Lauroyl Millet Amino Acids, Sodium Lauroyl / Myristoyl Aspartate, Sodium Lauroyl Oat Amino Acids, Sodium Lauroyl Sarcosinate, Sodium Lauroyl Silk Amino Acids, Sodium Lauroyl Taurate, Sodium Lauroyl Wheat Amino Acids, Sodium Lauryl Di (Ethylenediamino) Glycine, Sodium Lauryl Glucose Carboxylate, Sodium Lauryl Glucoside Hydroxypropyl Phosphate, Sodium Lauryl Glucoside Hydroxypropyl Sulfonate, Sodium Lauryl Glycol Carboxylate, Sodium Lauryl Glycol Sulfate, Disodium Lauryl Phosphate, Sodium Lauryl Sulfate, Sodium Lauryl Sulfoacetate, Sodium Linoleate, Sodium Macadamia Seed Oil Acid, Sodium Mango Amphoacetate, Sodium Mango Seed Oil Esters,Sodium Laureth-2 Sulfosuccinate / MEA, Sodium Methoxy PPG-2 Acetate, Sodium Methyl Cocoyl Taurate, Sodium Methyl Lauroyl Taurate, Sodium Methyl Myristoyl Taurate, Sodium Methyl Oleoyl Taurate, Sodium Methyl Palmitoyl Taurate, Sodium Methyl Stearoyl Taurate, Sodium Methyl 2-Sulfolaurate, Sodium Methyl 2-Sulfopalmitate, Sodium Isopalmitoyl Methyl Taurate, Sodium Methyl Cocoyl Methyl Taurate, Sodium Myristeth Sulfate, Sodium Myristate, Sodium Myristoyl Amphoacetate, Sodium Myristoyl Glutamate, Myristoyl Water Sodium decollagen, Sodium myristoyl isethionate, Sodium myristoyl sarcosinate, Sodium myristyl sulfate, Sodium nonoxynol 6 phosphate, Sodium nonoxynol 9 phosphate, Sodium nonoxynol 1 sulfate, Sodium nonoxynol 3 sulfate, Sodium nonoxynol 4 sulfate, Sodium nonoxynol 6 sulfate, Sodium nonoxynol 8 sulfate, Sodium nonoxynol 10 sulfate, Sodium nonoxynol 25 sulfate, Sodium octylphenol 2 ethanesulfonate, Sodium octylphenol 2 sulfate, Sodium octylphenol 6 sulfate, Sodium octylphenol 9 sulfate Sodium ester, sodium oleate, sodium oleoamphoacetate, sodium oleoamphohydroxypropyl sulfonate, sodium oleoamphopropionate, sodium oleoyl hydrolyzed collagen, sodium oleoyl isethionate, sodium oleyl polyether sulfate, sodium oleoyl methyl isethionate, sodium oleyl sulfate, sodium oliveoamphoacetate, sodium olive oil, sodium oliveoyl glutamate, sodium palmitoleoamphoacetate, sodium palmitoleate, sodium palmitoleyl glyceride sulfonate, sodium palmitate, sodium palmitoyl hydrolyzed collagen, sodium palmitoyl hydrolyzed wheat protein, sodium palmitoyl sarcosine, sodium palm kerneloleate, sodium palmitoleoyl isethionate, palm Sodium Oleoyl Glutamate, Sodium Passionflower Seed Oil, Sodium Peanut Amphoacetate, Sodium Peanut Acid, Sodium PEG-6 Cocoamide Carboxylate, Sodium PEG-8 Cocoamide Carboxylate, Sodium PEG-4 Cocoamide Sulfate, Sodium PEG-3 Lauramide Carboxylate, Sodium PEG-4 Lauramide Carboxylate, Sodium PEG-8 Palm Glycerides Carboxylate, Sodium Pentaerythrityl Hydroxypropyliminodiacetate Dendrimer, Sodium Propoxy PPG-2 Acetate, Sodium Rapeseed Oil, Sodium Rice Bran Amphoacetate, Sodium Ricinoleate, Sodium Ricinole Amphoacetate, Sodium Rose Hipsamphoacetate, Sodium Rosinate, Sodium Safflower Oleate, Sodium Saffloweroyl Hydrolyzed Soy Protein, Sodium Sesame Seed Oleate, Sodium Sesame Amphoacetate, Sodium Shea Butter Amphoacetate, Sodium Soy Oleate, Sodium Soy Hydrolyzed Collagen, Sodium Stearate, Sodium Stearoyl Amphoacetate, Sodium Stearoyl Amphopropyl Sulfonate, Sodium Stearoyl Amphopropionate, Sodium Stearoyl Casein, Sodium Stearoyl Glutamate, Sodium Stearoyl Hyaluronate, Sodium Stearoyl Hydrolyzed Collagen, Sodium Stearoyl Hydrolyzed Corn Protein, Sodium Stearoyl Hydrolyzed Silk, Sodium Stearoyl Hydrolyzed Soy Protein, Sodium Stearoyl Hydrolyzed Wheat Protein, Sodium Stearoyl Whey Protein, Sodium Stearoyl Methyl Isethionate, Sodium Stearoyl Oat Protein,Sodium stearoyl pea protein, sodium stearoyl soy protein, sodium stearyl dimethyl glycinate, sodium stearyl sulfate, sodium sunflower seed oil acyl amphoacetate, sodium subtilisin, sodium sweet almond oil acyl amphoacetate, sodium sweet almond oil acid, sodium tallow acyl propionate, sodium tallow acid, sodium tallow acyl acetate, sodium tallow acid, sodium tallow alcohol sulfate, sodium callophyllum (CALLOPHYLLUMINOPHYLLUM) seed oil acid, sodium taurine, sodium cocoyl methyl taurate taurate, laurel Sodium taurate, sodium lauroyl collagen amino acid / TEA salt, sodium lauroyl hydrolyzed collagen / TEA salt, sodium lauroyl hydrolyzed keratin / TEA salt, sodium lauroyl keratin amino acid / TEA salt, sodium undecylenyl collagen amino acid / TEA salt, sodium undecylenyl hydrolyzed collagen / TEA salt, sodium undecylenyl hydrolyzed corn protein / TEA salt, sodium undecylenyl hydrolyzed soy protein / TEA salt, sodium undecylenyl hydrolyzed wheat protein / TEA salt, Theobroma grandiflora Grandiflorum) seed oil sodium, sodium trideceth-3 carboxylate, sodium trideceth-4 carboxylate, sodium trideceth-6 carboxylate, sodium trideceth-7 carboxylate, sodium trideceth-8 carboxylate, sodium trideceth-12 carboxylate, sodium trideceth-15 carboxylate, sodium trideceth-19 carboxylate, sodium trideceth sulfate, sodium tridecylbenzene sulfonate, sodium tridecyl sulfate, sodium trimethylolpropane hydroxypropyl iminodiacetic acid dendrimer Compounds, sodium undecylene-5 carboxylate, sodium undecylenate, sodium undecylenylamphoacetate, sodium undecylenylamphopropionate, disodium undecylenyl glutamate, sodium wheat germ oleylamphoacetate, sorbitan polyether-160 tristearate, soybean oleic acid, soybean amidopropylamine oxide, soybean amidopropyl betaine, soybean glyceryl polyether-8 esters, stearamidopropylamine oxide, stearamidopropyl betaine, stearamine oxide, steareth-15, stearyl alcohol polyether Steareth-16, Steareth-20, Steareth-21, Steareth-25, Steareth-27, Steareth-30, Steareth-40, Steareth-50, Steareth-80, Steareth-100, Steareth-2 Phosphate, Steareth-3 Phosphate, Stearic Acid, Stearoxypropyltrimonium Chloride, Stearoyl Glutamic Acid, Stearoyl Sarcosine, Stearyl Betaine, Stearyl Dimethyl Butyl Glucoside Hydroxypropyl Ammonium Chloride, Stearic Acid, Lipoic acid dimethyl decyl glucoside hydroxypropyl ammonium chloride, stearyl dimethyl lauryl glucoside hydroxypropyl ammonium chloride, sulfated castor oil, sulfated coconut oil, sulfated glyceryl oleate, sulfated olive oil, sulfated peanut oil, sunflower oleamide MEA, sunflower oil acid, sunflower oil amidopropyl hydroxyethyl dimonium chloride, sunflower oil glyceryl polyether-8 esters, tallow acid, tallow acid, tallow amidopropylamine oxide, tallow amidopropyl betaine, tallow amidopropyl hydroxysulfonate,Tallowamine oxide, tallow betaine, tallow dihydroxyethyl betaine, tallow ethyl glucoside, abietic hydrolyzed collagen TEA salt, C12-14 alcohol phosphate TEA salt, C10-15 alkyl sulfate TEA salt, C11-15 alcohol sulfate TEA salt, C12-13 alkyl sulfate TEA salt, TEA-C12-14 alkyl sulfate TEA salt, TEA-C12-15 alkyl sulfate TEA salt, TEA C14-17 secondary alkyl sulfonate TEA salt, canola oil TEA salt, cocamide diacetate TEA salt, coconut oil acid TEA salt, coconut oil alcohol sulfate TEA salt, cocoyl alanine TEA salt, cocoyl glutamate TEA salt, cocoyl glutamine TEA salt, cocoyl glycine TEA salt, cocoyl hydrolyzed collagen TEA salt, cocoyl hydrolyzed soy protein TEA salt, cocoyl sarcosine TEA salt, polydimethylsiloxane PEG-7 phosphate TEA salt, dodecylbenzene sulfonate TEA salt, hydrogenated coconut acid TEA salt, hydrogenated tallow glutamate TEA salt, isostearic acid TEA salt, TEA-Isostearyl Hydrolyzed Collagen TEA Salt, Lauryl Amine Propionic Acid TEA Salt, Lauric Acid TEA Salt, Lauric Acid / Myristic Acid TEA Salt, Laureth Sulfate TEA Salt, Lauroyl Collagen Amino Acid TEA Salt, Lauroyl Glutamate TEA Salt, Lauroyl Hydrolyzed Collagen TEA Salt, Lauroyl Keratin Amino Acid TEA Salt, Lauroyl Methylaminopropionic Acid TEA Salt, Lauroyl / Myristoyl Aspartic Acid TEA Salt, Lauroyl Sarcosine TEA Salt, Lauryl Phosphate TEA Salt, Lauryl Sulfate TEA Salt, Myristyl Amine Propionic Acid TEA Salt, Myristyl Acid TEA Salt, Myristoyl Hydrolyzed Collagen TEA salt, TEA oleate, TEA oleoyl hydrolyzed collagen, TEA oleoyl sarcosine, TEA oleyl sulfate, TEA palmitate, TEA palm kernel sarcosine, TEA PEG-3 cocamide sulfate, TEA rosinate, TEA stearate, TEA tallate, TEA tridecylbenzenesulfonate, TEA undecylenate, TEA undecylenate hydrolyzed collagen, tetramethyldecynediol, tetrasodium dicarboxyethyl stearyl sulfosuccinamate, TIPA laureth sulfate, TIPA lauryl sulfate, TIPA myristic acid, TIPA stearate, Tocopheryl phosphate, trehalose undecylenate, TM-C12-15 pareth-2 phosphate, TM-C12-15 pareth-6 phosphate, TM-C12-15 pareth-8 phosphate, TM-C12-15 pareth-10 phosphate, trideceth-20, trideceth-50, trideceth-3 carboxylic acid, trideceth-4 carboxylic acid, trideceth-7 carboxylic acid, trideceth-8 carboxylic acid, trideceth-15 carboxylic acid, trideceth-19 carboxylic acid, trideceth-10 phosphate, tridecylbenzenesulfonic acid, trilaureth-9 citrate,Trimethylolpropane Hydroxypropyl Bis(hydroxyethyl)amine Dendrimer, Sodium Tri(lauroampho PG-acetate chloride) Phosphate, Undecanoic Acid, Undeceth-5 Carboxylic Acid, Undecylenamidopropylamine Oxide, Undecylenamidopropyl Betaine, Undecylenic Acid, Undecylenyl Collagen Amino Acids, Undecylenyl Glycine, Undecylenyl Hydrolyzed Collagen, Undecylenyl Wheat Amino Acids, Undecyl Glucoside, Wheat Germ Oleic Acid, Wheat Germ Oleic Acid, Wheat Germ Oleic Acid, Wheat Germ Oleic Acid, Wheat Germ Oleic Acid, Yucca Schidigera Leaf / Root / Stem Extract, Yucca Schidigera Stem Extract, Zinc Cocoeth Sulfate and Zinc Cocoyl Sulfate.

[0036] Preferred are one or more compounds selected from the group consisting of sodium laureth sulfate, cocamidopropyl betaine, sodium cocoamphoacetate, coco-glucoside and ammonium lauryl sulfosuccinate.

[0037] The percentage content of the surfactant in the preparation may be 0.1 to 10% by weight, and preferably 0.5 to 5% by weight, based on the preparation.

[0038] Oil body

[0039] Suitable oil bodies, which are a component of O / W emulsions, are based, for example, on Guerbet alcohols containing 6 to 18, preferably 8 to 10, carbon atoms, linear C6-C 22 -Fatty acids with straight or branched C6-C 22 -Ester of aliphatic alcohol or branched C6-C 13 -Carboxylic acid with straight or branched C6-C 22- esters of fatty alcohols, such as, for example, myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, stearyl Isostearyl, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate and erucyl erucate. Also suitable are straight-chain C6-C 22 - Esters of fatty acids with branched alcohols, especially 2-ethylhexanol, C 18 -C 38 -alkyl hydroxycarboxylic acid with a straight or branched C6-C 22 - esters of fatty alcohols, in particular dioctyl malate, esters of linear and / or branched fatty acids with polyols (such as, for example, propylene glycol, dimerdiol or trimertriol) and / or Guerbet alcohols, 10 -Triglycerides of fatty acids, based on C6-C 18 -Liquid mono- / di- / triglyceride mixture of fatty acids, C6-C 22 - esters of aliphatic alcohols and / or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, C2-C 12 - esters of dicarboxylic acids with straight-chain or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, straight-chain and branched C6-C 22 - Carbonates of fatty alcohols, such as, for example, dicaprylyl carbonate ( C-C), Guerbet carbonates based on aliphatic alcohols having 6 to 18, preferably 8 to 10, carbon atoms, benzoic acid and linear and / or branched C6-C 22 -Ester of alcohol (e.g. TN), linear or branched, symmetrical or asymmetrical dialkyl ethers in which each alkyl radical has 6 to 22 carbon atoms, such as, for example, dicaprylyl ether ( OE), ring-opening products of epoxidized fatty acid esters with polyols, silicone oils (cyclopolydimethylsiloxane, silicone methicone grades, etc.) and / or aliphatic or cycloalkanes, such as, for example, squalane, squalene or dialkylcyclohexanes.

[0040] Emulsifier

[0041] Other nonionic or cationic surfactants may also be added to the formulation as emulsifiers, including for example:

[0042] · 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with linear C 8-22 Aliphatic alcohols, and C 12-22 Addition products of fatty acids and alkylphenols having 8 to 15 carbon atoms in the alkyl group;

[0043] · C of addition products of 1 to 30 mol of ethylene oxide onto glycerol 12 / 18 Fatty acid monoesters and diesters;

[0044] glycerol monoesters and diesters and sorbitan monoesters and diesters of saturated and unsaturated fatty acids containing 6 to 22 carbon atoms and their ethylene oxide addition products;

[0045] Addition products of 15 to 60 mol of ethylene oxide onto castor oil and / or hydrogenated castor oil;

[0046] Polyol esters, in particular polyglycerol esters such as polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate or polyglycerol dimer oil isostearate. Also suitable are mixtures of a plurality of such compounds;

[0047] Addition products of 2 to 15 mol of ethylene oxide onto castor oil and / or hydrogenated castor oil;

[0048] Based on straight chain, branched, unsaturated or saturated C 6 / 22 Partial esters of fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g. sorbitol), alkyl glucosides (e.g. methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (e.g. cellulose);

[0049] Mono-, di- and tri-alkyl phosphates and mono-, di- and / or tri-PEG alkyl phosphates and their salts;

[0050] Wool wax alcohols;

[0051] Polysiloxane / polyalkyl polyether copolymers and corresponding derivatives;

[0052] Pentaerythritol, fatty acids, citric acid and aliphatic alcohols and / or C 6-22A mixed fat of fatty acids, methyl glucose and a polyol, preferably glycerol or polyglycerol;

[0053] Alkyl and / or alkenyl oligoglycosides;

[0054] Polyglycols and

[0055] Glyceryl carbonate.

[0056] The addition products of ethylene oxide and / or propylene oxide with aliphatic alcohols, fatty acids and alkylphenols, mono- and diesters of glycerol and sorbitan mono- and diesters of fatty acids or castor oil are commercially available products. They are homologous mixtures whose average degree of alkoxylation corresponds to the ratio of the amount of ethylene oxide and / or propylene oxide and substrate used for the addition reaction. 12 / 18 Fatty acid monoesters and diesters are known for use as superfatting agents for cosmetic preparations. Preferred emulsifiers are listed in detail below:

[0057] Partial glycerides. Typical examples of suitable partial glycerides are hydroxystearic acid monoglyceride, hydroxystearic acid diglyceride, isostearic acid monoglyceride, isostearic acid diglyceride, oleic acid monoglyceride, oleic acid diglyceride, ricinoleic acid monoglyceride, ricinoleic acid diglyceride, linoleic acid monoglyceride, linoleic acid diglyceride, linoleic acid monoglyceride, linoleic acid diglyceride, erucic acid monoglyceride, erucic acid diglyceride, tartaric acid monoglyceride, tartaric acid diglyceride, citric acid monoglyceride, citric acid diglyceride, malic acid monoglyceride, malic acid diglyceride and technical mixtures thereof which still contain small amounts of triglycerides originating from the production process. Addition products of 1 to 30 and preferably 5 to 10 mol of ethylene oxide to the abovementioned partial glycerides are also suitable.

[0058] Sorbitan esters. Suitable sorbitan esters are sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan trioleate, sorbitan monoerucate, sorbitan sesquierucate, sorbitan dierucate, sorbitan trierucate, sorbitan monoricinoleate, sorbitan sesquiricinoleate, sorbitan diricinoleate, sorbitan triricinoleate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan trioleate, sorbitan monoerucate, sorbitan sesquierucate, sorbitan dierucate, sorbitan trierucate, sorbitan monoricinoleate, sorbitan sesquiricinoleate, sorbitan diricinoleate, sorbitan triricinoleate, sorbitan monooleate, sorbitan sesquioleate, sorbitan di ...oleate, sorbitan monooleate, sorbitan Suitable esters include sorbitan monohydroxystearate, sorbitan sesquihydroxystearate, sorbitan dihydroxystearate, sorbitan trihydroxystearate, sorbitan monotartrate, sorbitan sesquitartrate, sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimalate and technical mixtures thereof. Also suitable are the addition products of 1 to 30 and preferably 5 to 10 mol of ethylene oxide to the abovementioned sorbitan esters.

[0059] Polyglycerol esters. A typical example of a suitable polyglycerol ester is polyglyceryl-2 dipolyhydroxystearate ( PGPH), polyglyceryl-3-diisostearate ( TGI), polyglyceryl-4 isostearate ( GI 34), Polyglyceryl-3 Oleate, Diisostearyl Polyglyceryl-3 Diisostearate ( PDI), Polyglyceryl-3 Methyl Glucose Distearate (Tego 450), Polyglyceryl-3 Beeswax (Cera )、Polyglyceryl-4 Caprate (Polyglyceryl Caprate T2010 / 90), Polyglyceryl-3 Cetyl Ether ( NL), Polyglyceryl-3 Distearate ( GS 32) and polyglycerol polyricinoleate ( WOL 1403), polyglyceryl dimerateisostearate and mixtures thereof. Other examples of suitable polyol esters are the monoesters, diesters and triesters of lauric acid, coconut acid, tallow acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like, optionally reacted with 1 to 30 mol of ethylene oxide, and trimethylolpropane or pentaerythritol.

[0060] Alkyl and / or alkenyl oligoglycosides. Alkyl and / or alkenyl oligoglycosides, their preparation and their use are known in the prior art. They are prepared in particular by reacting glucose or oligosaccharides with primary alcohols containing 8 to 18 carbon atoms. With regard to the glycoside residues, monoglycosides, in which the cyclic sugar residue is glycosidically bonded to the fatty alcohol, and oligoglycosides having a degree of oligomerization preferably up to about 8 are suitable. The degree of oligomerization is a statistical mean value based on the distribution of homologues customary for such technical products.

[0061] Tetraalkyl quaternary ammonium salts. Cationic surfactants in aqueous solution contain hydrophobic polymer groups required for surface activity in dissociated cations. An important representative of cationic surfactants is the general formula (R 1 R 2 R 3 R 4 N + )X - A tetraalkyl quaternary ammonium salt. 1 represents C1-C8 alkane (alkenyl), R 2 , R 3 and R 4 ,

[0062] Independently represent an alkane (enyl) group containing 1 to 22 carbon atoms. X is a counter ion, preferably selected from halogen, alkyl sulfate and alkyl carbonate. Particularly preferred are cationic surfactants, wherein the nitrogen atom is substituted by two long acyl groups and two short alkane (enyl) groups.

[0063] Esterquats. A group of cationic surfactants which are particularly useful as cosurfactants according to the invention are the so-called esterquats. Esterquats are generally understood to mean quaternized fatty acid triethanolamine ester salts. They are known compounds which can be obtained by relevant processes of preparative organic chemistry. Reference is made in this regard to the international patent application WO 91 / 01295 A1, in which triethanolamine is partially esterified with fatty acids in the presence of hypophosphorous acid, air is passed through the reaction mixture and the whole is subsequently quaternized with dimethyl sulfate or ethylene oxide. In addition, German patent DE 4308794 C1 describes a process for preparing solid esterquats, in which the quaternization of the triethanolamine ester is carried out in the presence of a suitable dispersant, preferably a fatty alcohol.

[0064] A typical example of an esterquat suitable for use according to the invention is a product whose acyl component is derived from a monocarboxylic acid corresponding to the formula RCOOH, wherein RCO is an acyl group containing 6 to 10 carbon atoms, and the amino component is triethanolamine (TEA). Examples of such monocarboxylic acids are caproic acid, caprylic acid, capric acid and technical mixtures thereof, such as, for example, so-called head fractionated fatty acids. Preferably used esterquats whose acyl component is derived from a monocarboxylic acid containing 8 to 10 carbon atoms. Other esterquats are those whose acyl component is derived from dicarboxylic acids such as malonic acid, succinic acid, maleic acid, fumaric acid, glutaric acid, sorbic acid, pimelic acid, azelaic acid, sebacic acid and / or dodecanedioic acid, but preferably adipic acid. In general, it is preferred to use esterquats whose acyl component is derived from a mixture of monocarboxylic acids containing 6 to 22 carbon atoms and adipic acid. The molar ratio of monocarboxylic acid to dicarboxylic acid in the final esterquat is from 1:99 to 99:1, and preferably from 50:50 to 90:10 and more particularly from 70:30 to 80:20. In addition to quaternized fatty acid triethanolamine ester salts, other suitable esterquats are quaternized ester salts of mono / dicarboxylic acid mixtures with diethanolalkylamine or 1,2-dihydroxypropyldialkylamine. Esterquats can be obtained from fatty acids and from the corresponding triglycerides mixed with the corresponding dicarboxylic acids. One such process, which is representative of the relevant prior art, is proposed by European patent EP 0750606B1. For the preparation of the quaternized esters, mixtures of mono- and dicarboxylic acids with triethanolamine in a molar ratio of 1.1:1 to 3:1 can be used - based on the available carboxyl functions. Considering the properties of the esterquats, ratios of 1.2:1 to 2.2:1 and in particular 1.5:1 to 1.9:1 have proven to be particularly advantageous. Preferred esterquats are technical mixtures of mono-, di- and triesters having an average degree of esterification of 1.5 to 1.9.

[0065] Superfatting agents and consistency factors

[0066] Superfatting agents may be selected from substances such as, for example, lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides, the latter also serving as foam stabilizers.

[0067] The main consistency factors used are fatty alcohols or hydroxyaliphatic alcohols and partial glycerides, fatty acids or hydroxyfatty acids having 12 to 22 and preferably 16 to 18 carbon atoms. Preference is given to using combinations of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12-hydroxystearate.

[0068] Thickeners and rheology additives

[0069] Suitable thickeners are polymeric thickeners, such as polysaccharides, more particularly xanthan gum, guar gum, agar, alginates and tyloses, carboxymethylcellulose and hydroxyethylcellulose, and relatively high molecular weight polyethylene glycol monoesters and diesters of fatty acids, polyacrylates (e.g. [Goodrich] or [Sigma]), polyacrylamide, polyvinyl alcohol and polyvinyl pyrrolidone, surfactants such as, for example, ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as pentaerythritol or trimethylolpropane, narrow homolog distribution fatty alcohol ethoxylates and electrolytes such as sodium chloride and ammonium chloride.

[0070] polymer

[0071] Suitable cationic polymers are, for example, cationic cellulose derivatives, such as are available from Amerchol as Polymer JR Quaternized hydroxyethylcellulose obtained under the name of quaternized hydroxyethylcellulose, cationic starch, copolymers of diallyl ammonium salt and acrylamide, quaternized vinyl pyrrolidone / vinylimidazole polymers, for example (BASF), condensates of polyethylene glycol and amines, quaternized collagen peptides, such as lauryl diammonium hydroxypropyl hydrolyzed collagen ( L, Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers, such as aminodimethicone, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine ( Sandoz), copolymer of acrylic acid and dimethyldiallylammonium chloride ( 550, Chemviron), polyaminopolyamides and crosslinked water-soluble polymers thereof, cationic chitin derivatives, such as quaternized chitosan, optionally in microcrystalline distribution, condensation products of dihaloalkanes, such as dibromobutane, and bisdialkylamines, such as bisdimethylamino-1,3-propane, cationic guar gums, such as Celanese CBS, C-17, C-16, quaternary ammonium polymers, such as Miranol A-15, AD-1, AZ-1, and can be marketed under the trade name CC or Various polyquaternium types found in 300 (e.g. 6, 7, 32 or 37).

[0072] Suitable anionic, zwitterionic, amphoteric and nonionic polymers are, for example, vinyl acetate / crotonic acid copolymers, vinyl pyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their esters, uncrosslinked and polyol-crosslinked polyacrylic acids, acrylamidopropyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate / tert-butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinylcaprolactam terpolymers and optionally derivatized cellulose ethers and silicones.

[0073] Pearlescent wax

[0074] Suitable pearlescent waxes are, for example, alkanediol esters, especially ethylene glycol distearate; fatty acid alkanolamides, especially coconut fatty acid diethanolamide; partial glycerides, especially stearic acid monoglyceride; esters of polybasic, optionally hydroxy-substituted carboxylic acids with fatty alcohols having 6 to 22 carbon atoms, especially long-chain esters of tartaric acid; fatty substances having a total of at least 24 carbon atoms, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, especially laurone and distearyl ether; fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring-opening products of epoxides having 12 to 22 carbon atoms with fatty alcohols having 12 to 22 carbon atoms and / or polyols having 2 to 15 carbon atoms and 2 to 10 hydroxyl groups, and mixtures thereof.

[0075] Silicone

[0076] Suitable silicones are selected from the group consisting of: theophylline methylsilanol mannuronate, acetylmethionylmethylsilanol elastin esters, acrylates / behenyl acrylate, acrylates / dimethicone methacrylate copolymer, acrylates / behenyl methacrylate / dimethicone methacrylate copolymer, acrylates / bishydroxypropyl dimethicone crosspolymer, acrylates / dimethicone copolymer, acrylates / dimethicone methacrylate / ethylhexyl acrylate copolymer, acrylates / dimethicone alcohol acrylate copolymer, acrylates / ethylhexyl acrylate / dimethicone methacrylate Acid copolymer, acrylates / octylacrylamide / diphenyl amino-terminated polydimethylsiloxane copolymer, acrylates / polytrimethylsiloxane methacrylate copolymer, acrylates / propyl polytrimethylsiloxane methacrylate copolymer, acrylates / stearyl alcohol acrylate / polydimethylsiloxane methacrylate copolymer, acrylates / tridecyl acrylate / triethoxysilylpropanol methacrylate / polydimethylsiloxane methacrylate copolymer, acrylates / trifluoropropyl methacrylate / polytrimethylsiloxane methacrylate copolymer, aminobispropyl polydimethylsiloxane, aminoethylaminopropyl polydimethylsiloxane, aminopropyl polydimethylsiloxane, amino Propyl phenyl trimethicone, aminopropyl triethoxysilane, dimethicone PEG-7 ammonium sulfate, amodimethicone, amodimethicone hydroxystearate, amodimethicone / silsesquioxane copolymer, ascorbyl carboxydecyl trisiloxane, ascorbyl methylsilanol pectate, behenoxy dimethicone, behentrimonium dimethicone PEG-8 phthalate, behenyl dimethicone, bisamino PEG / PPG-41 / 3 aminoethyl PG-propyl dimethicone, bis-aminopropyl / ethoxyaminopropyl dimethicone, bis(butyl benzoate) diaminotriazine aminopropyl trisiloxane, bis-butyl dimethicone polyglyceryl- 3. Bis-butoxy amino dimethicone / PEG-60 copolymer, bis (C13-15 alkoxy) hydroxybutyramide amino dimethicone, bis (C13-15 alkoxy) PG-amino dimethicone, bis (C1-8 alkyl lauroyl lysine decyl carboxamide) dimethicone, bis-cetyl cetyl dimethicone, bis-cetyl / PEG-8 cetyl PEG-8 dimethicone, bis-diphenylethyl dimethicone, bis-ethylethyl dimethicone, bis-glucamideethyl-aminopropyl dimethicone, bis-hydrogen dimethicone, bis-hydroxyethoxypropyl dimethicone bis-hydroxylauryl, dimethicone / IPDI copolymer,Bis-Hydroxy / Methoxy Amodimethicone, Bis-Hydroxypropyl Dimethicone Behenate, Bis-Hydroxypropyl Dimethicone / SMDI Copolymer, Bis-Isobutyl PEG-14 / Amodimethicone Copolymer, Bis-Isobutyl PEG-15 / Amodimethicone Copolymer, Bis-Isobutyl PEG / PPG-20 / 35 / Amodimethicone Copolymer, Bis-Isobutyl PEG / PPG-10 / 7 / Dimethicone Copolymer, Bis-Isobutyl PEG-24 / PPG-7 / Dimethicone Copolymer, Bis-PEG-1 Dimethicone, Bis-PEG-4 Dimethicone, Bis-PEG-8 Dimethicone, Bis-PEG-12 Dimethicone 、Bis-PEG-20 Dimethicone、Bis-PEG-12 Dimethicone Beeswax、Bis-PEG-12 Dimethicone Candelilla Wax Acid、Bis-PEG-15 Dimethicone / IPDI Copolymer、Bis-PEG-15 Methyl Ether Dimethicone、Bis-PEG-18 Methyl Ether Dimethyl Silane、Bis-PEG / PPG-14 / 14 Dimethicone、Bis-PEG / PPG-15 / 5 Dimethicone、Bis-PEG / PPG-18 / 6 Dimethicone、Bis-PEG / PPG-20 / 20 Dimethicone、Bis-PEG / PPG-16 / 16 PEG / PPG-16 / 16 Dimethicone、Bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 Dimethicone, Bis-phenylhexamethicone, Bis-phenylpropyl Dimethicone, Bis-polyethylene Dimethicone, Bis-(polyglyceryl-3 oxyphenylpropyl) Dimethicone, Bis-(polyglyceryl-7 oxyphenylpropyl) Dimethicone, Bis-PPG-15 Dimethicone / IPDI Copolymer, Bis-(PPG-7 Undecene Alcohol Polyether-21) Dimethicone, Bis-stearyl Dimethicone, Bis-trimethoxysilylethyl Tetramethyldisiloxyethyl Dimethicone, Bis-vinyl Dimethicone, Bis-vinyl Dimethicone / Dimethicone Copolymer, Borago Seed Oil PEG-7 Dimethicone Ester Class, Butyl Acrylate / C6-14 Perfluoroalkyl Alcohol Acrylate / Mercaptopropyl Dimethicone Copolymer, Butyl Acrylate / Hydroxypropyl Dimethicone Acrylate Copolymer, Butyl Dimethicone Acrylate / Cyclohexyl Methacrylate / Ethylhexyl Acrylate Copolymer, Butyl Dimethicone Methacrylate / Methyl Methacrylate Crosspolymer, T-Butyl Dimethyl Silane Grape Seed Extract, Butyl Dimethicone Ethylene / Propylene / Ethylene Norbornene Copolymer, C6-8 Alkyl C3-6 Alkyl Glucoside Dimethicone, C20-24 Alkyl Dimethicone, C24-28 Alkyl Dimethicone, C26-28 Alkyl Dimethicone,C30-45 Alkyl Dimethicone, C30-60 Alkyl Dimethicone, C32 Alkyl Dimethicone, C30-45 Alkyl Dimethicone / Polycyclohexene Oxide Crosspolymer, C26-28 Alkyl Dimethyl Silane Polypropyl Silsesquioxane, C30-45 Alkyl Dimethyl Silane Polypropyl Silsesquioxane, C20-24 Alkyl Methicone, C24-28 Alkyl Methicone, C26-28 Alkyl Methicone, C30-45 Alkyl Methicone, C20-28 Alkyl Fluordecyl Ethoxy Dimethicone, C26-54 Alkyl Tetradecyl Dimethicone, Caprylyl Dimethicone, Caprylyl Dimethicone Ethoxy Glucoside, Caprylyl Methicone, Caprylyl Trimethicone, Carboxydecyl Trisiloxane, Castor Oil Bis-Hydroxypropyl Dimethicone Esters, Wax Dimethicone, Cetearyl Dimethicone Crosspolymer, Cetearyl Dimethicone / Vinyl Dimethicone Crosspolymer, Cetearyl Methicone, Cetrimonium Carboxydecyl PEG-8 Polydimethylsiloxane Dimethicone, Cetyl Dimethicone, Cetyl Dimethicone, Cetyl Dimethicone / Bis-vinyl Dimethicone Crosspolymer, Cetyl Dimethicone, Cetyl Dimethicone, Cetyl PEG-8 Dimethicone, Cetyl PEG / PPG-15 / 15 Butyl Ether Dimethicone, Cetyl PEG / PPG-7 / 3 Dimethicone, Cetyl PEG / PPG-10 / 1 Dimethicone Methylsiloxane, cetyl triethylammonium dimethicone PEG-8 phthalate, cetyl triethylammonium dimethicone PEG-8 succinate, acetyl tyrosine copper methylsilanol, PCA copper methylsilanol, C4-14 perfluoroalkyl ethoxy polydimethylsiloxane, cycloethoxy polymethicone, cycloheptylsiloxane, cyclohexasiloxane, cyclomethicone, cyclopentasiloxane, cyclophenyl polymethicone, cyclotetramethicone, cyclovinyl polymethoxysilane, cystine bis-PG-propyl silanetriol, DEA PG-propyl PEG / PPG-18 / 21 dimethicone, diisostearyl trimethylolpropane siloxysilicate, dilauroyl trimethylolpropane siloxysilicate, dilinoleamidopropyl dimethylamine dimethicone PEG-7 phosphate, dimethicone, dimethicone crosspolymer, dimethicone crosspolymer-3, dimethicone / divinyl dimethicone / silsesquioxane crosspolymer, dimethicone ethoxylated glucoside, dimethicone hydroxypropyltrimonium chloride, dimethicone / mercaptopropyl methicone copolymer, dimethicone PEG-15 acetate,Dimethicone PEG-8 Adipate, Dimethicone PEG-7 Avocado Oleate, Dimethicone PEG-8 Avocado Oleate, Dimethicone PEG-8 Beeswax, Dimethicone PEG-8 Benzoate, Dimethicone PEG-8 Borage Oleate, Dimethicone PEG-7 Cocoate, Dimethicone / PEG-10 Crosspolymer, Dimethicone PEG-10 / 15 Crosspolymer, Dimethicone / PEG-15 Crosspolymer, Dimethicone PEG-7 Isostearate, Dimethicone PEG-8 Isostearate, Dimethicone PEG-7 Lactate, Dimethicone PEG -8 Lanolin Acid, Dimethicone PEG-8 Laurate, Dimethicone PEG-8 Limnanthes Alba Seed Oil Acid, Dimethicone PEG-7 Octyldodecyl Citrate, Dimethicone PEG-7 Olivate, Dimethicone PEG-8 Olivate, Dimethicone PEG-7 Phosphate, Dimethicone PEG-8 Phosphate, Dimethicone PEG-10 Phosphate, Dimethicone PEG-7 Phthalate, Dimethicone PEG-8 Phthalate, Dimethicone PEG-8 Polyacrylate, Dimethicone PEG / PPG-20 / 23 Benzoate, Dimethicone PEG / PPG- 7 / 4 phosphate, dimethicone PEG / PPG-12 / 4 phosphate, dimethicone PEG-7 succinate, dimethicone PEG-8 succinate, dimethicone PEG-7 sulfate, dimethicone PEG-7 undecanoate, dimethicone PG-diethylmethylmonium chloride, dimethicone / phenyl vinyl dimethicone crosspolymer, dimethicone / polyglyceryl-3 crosspolymer, dimethicone / PPG-20 crosspolymer, dimethicone propyl ethylenediamine behenate, dimethicone propyl PG-betaine, dimethicone / silsesquioxane copolymer, dimethicone silylate, dimethicone Siloxane / vinyl dimethicone crosspolymer, dimethicone / vinyl trimethylsiloxysilicate crosspolymer, dimethiconol, dimethicone arginine, dimethicone beeswax acid ester, dimethicone behenate, dimethicone boragonate, dimethicone candelilla wax acid ester, dimethicone carnaubamate, dimethicone cysteine, dimethicone drupaate, dimethicone fluoroalcohol dimer linoleic acid polyester, dimethicone hydroxystearate, dimethicone indica hematite resinate, dimethicone / IPDI copolymer, dimethicone isostearate,Dimethicone Candle Butter, Dimethicone Lactate, Dimethicone White Limnanthes Alba Seed Oil, Dimethicone Methionine, Dimethicone / Methylsilanol / Silicate Crosspolymer, Dimethicone Chenopodium Alpinum Lactate, Dimethicone Panthenol, Dimethicone Salicylate, Dimethicone / Silica Crosspolymer, Dimethicone / Silsesquioxane Copolymer, Dimethicone Stearate, Dimethicone / Stearyl Methicone / Phenyl Trimethicone Copolymer, Dimethoxysilyl Ethylene Diaminopropyl Dimethicone, Dimethylaminopropionamide PCA Polydimethylsiloxysilane Methicone, dimethyloxybenzodioxane, dimethylsilanol hyaluronate, dioleyl tocopheryl methylsilanol, diphenyl amodimethicone, diphenyl dimethicone, diphenyl dimethicone crosspolymer, diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane crosspolymer, diphenylethyl benzyloxydimethyldisiloxane, diphenyl isopropyl dimethicone, diphenylsiloxyphenyl / propyl trimethicone, diphenylsiloxyphenyl trimethicone, dimethicone, disodium amodimethicone disuccinimide, disodium PEG-12 polydimethicone sulfosuccinate, PEG -8 lauryl dimethicone sulfosuccinate disodium, divinyl dimethicone / dimethicone copolymer, divinyl dimethicone / dimethicone crosspolymer, drometrizole trisiloxane, ethylhexyl acrylate / VP / dimethicone methacrylate copolymer, ethyl polymethicone, ethyl trisiloxane, fluorinated C2-8 alkyl polydimethicone, glucamidopropyl aminopropyl polydimethicone, 4-(2-β-pyranosyl methylsiloxy) propoxy-2-hydroxybenzophenone, glyceryl undecyl polydimethicone, glycidoxy polydimethicone, polyhexadecyl methicone, hexyl polydimethicone, hexyl polydimethicone Methylsiloxane, Hexyl Trimethoxysilane, Hydrogen Dimethicone, Hydrogen Dimethicone / Capryl Silsesquioxane Copolymer, Hydrolyzed Collagen PG-Propyl Dimethicone, Hydrolyzed Collagen PG-Propyl Methylsilanediol, Hydrolyzed Collagen PG-Propyl Silanetriol, Hydrolyzed Keratin PG-Propyl Methylsilanediol, Hydrolyzed Sesame Protein PG-Propyl Methylsilanediol, Hydrolyzed Silk PG-Propyl Methylsilanediol, Hydrolyzed Silk PG-Propyl Methylsilanediol Crosspolymer, Hydrolyzed Soy Protein / Dimethicone PEG-7 Acetate, Hydrolyzed Soy Protein PG-Propyl Methylsilanediol, Hydrolyzed Vegetable Protein PG-Propyl Silanetriol, Hydrolyzed Wheat (TRITICUM VULGARE) Protein / Cysteine ​​Bis-PG-Propyl Silanetriol Copolymer, Hydrolyzed Wheat Protein / Dimethicone PEG-7 Acetate,Hydrolyzed wheat protein / dimethicone PEG-7 phosphate copolymer, hydrolyzed wheat protein PG-propyl methylsilanediol, hydrolyzed wheat protein PG-propyl silanetriol, hydroxyethyl acetoxymethyl ammonium PG-dimethicone, hydroxypropyl dimethicone, hydroxypropyl dimethicone behenate, hydroxypropyl dimethicone isostearate, hydroxypropyl dimethicone stearate, isobutyl methacrylate / bis-hydroxypropyl dimethicone acrylate copolymer, isobutyl methacrylate / trifluoroethyl methacrylate / bis-hydroxypropyl dimethicone acrylate copolymer, isopentanol trimethoxycinnamate trisiloxane, isopolyglyceryl-3 dimethicone, isopolyglyceryl-3 dimethiconol 、Isopropyl Titanium Triisostearate / Triethoxysilylethyl, Polydimethylsiloxyethyl Dimethicone Crosspolymer, Isostearyl Carboxydecyl PEG-8 Dimethicone, Lactyl Methylsilanol Elastin Esters, Lauryl Dimethicone, Lauryl Dimethicone PEG-15 Crosspolymer, Lauryl Dimethicone PEG-10 Phosphate, Lauryl Dimethicone / Polyglyceryl-3 Crosspolymer, Lauryl Methicone, Lauryl PEG-8 Dimethicone, Lauryl PEG-10 Methyl Ether Dimethicone, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Lauryl PEG / PPG-18 / 18 Methicone, Lauryl Benzene Isopropyl Alcohol, Propyl Methicone, Lauryl Phenyl Propyl Methicone, Lauryl Dimethicone / Bis-Vinyl Dimethicone Crosspolymer, Lauryl Polyglyceryl-3 Dimethicone / Bis-Vinyl Dimethicone Crosspolymer, Lauryl Trimethicone, Linoleamidopropyl PG-Dimonium Chloride Phosphate Dimethicone, Methacryloylpropyl Trimethoxysilane, Methicone, Methoxyamodimethicone / Silsesquioxane Copolymer, Methoxycinnamamidopropyl Polysilsesquioxane, Methoxycinnamylpropyl Silsesquioxane Silicate, Methoxy PEG-13 Ethyl Polysilsesquioxane, Methoxy PEG / PPG-7 / 3 Aminopropyl Dimethicone, Methoxy PEG / PPG-2 5 / 4 Dimethicone, Methoxy PEG-10 Propyl Trimethoxy Silane, Methyl Eugenol PEG-8 Dimethicone, Methyl Polysiloxane Emulsion, Methylsilanol Acetyl Methionine Ester, Methylsilanol Acetyl Tyrosine Ester, Methylsilanol Ascorbate, Methylsilanol Carboxymethyl Theophylline, Methylsilanol Carboxymethyl Theophylline Alginate, Methylsilanol Elastin Ester, Methylsilanol Glycyrrhizate, Methylsilanol Hydroxyproline Ester, Methylsilanol Hydroxyproline Ester Aspartate, Methylsilanol Mannosuronate, Methylsilanol PCA Ester, Methylsilanol PEG-7 Glyceryl Cocoate, Methylsilanol / Silicate Crosspolymer, Methylsilanol Spirulina Protein Ester, Methylsilanol Tri-PEG-8 Glyceryl Cocoate,Methyl trimethicone, methyl trimethoxysilane, myristamidopropyl dimethylamine dimethicone PEG-7 phosphate, myristyl polymethicone, myristyl trisiloxane, nylon-611 / dimethicone copolymer, PCA dimethicone, PEG-7 amodimethicone, PEG-8 amodimethicone, PEG-8 cetyl dimethicone, PEG-3 dimethicone, PEG-6 dimethicone Siloxane, PEG-7 Dimethicone, PEG-8 Dimethicone, PEG-9 Dimethicone, PEG-10 Dimethicone, PEG-12 Dimethicone, PEG-14 Dimethicone, PEG-17 Dimethicone, PEG-10 Dimethicone Crosspolymer, PEG-12 Dimethicone Crosspolymer, PEG-8 Dimethicone Dimer, PEG-8 Dimethicone / Dimer Dilinoleate Copolymer, PEG-10 Dimethicone / Vinyl Dimethicone Crosspolymer, PEG-8 Distearyl Methylmonium Chloride PG-Dimethicone, PEG-10 / Lauryl Dimethicone Crosspolymer, PEG-15 / Lauryl Dimethicone Crosspolymer, PEG-15 / Lauryl Dimethicone Crosspolymer, PEG-8 Methicone, PE G-6 Polymethicone Acetate, PEG-6 Methyl Ether Polydimethicone, PEG-7 Methyl Ether Polydimethicone, PEG-8 Methyl Ether Polydimethicone, PEG-9 Methyl Ether Polydimethicone, PEG-10 Methyl Ether Polydimethicone, PEG-11 Methyl Ether Polydimethicone, PEG-32 Methyl Ether Polydimethicone, PEG-8 Methyl Ether Triethoxysilane, PEG-10 Nonafluorohexyl Polydimethicone Copolymer, PEG-4 PEG-12 Polydimethicone, PEG-8 PG Cocoyl Glucoside Dimethicone, PEG-9 Polydimethylsiloxyethyl Dimethicone, PEG / PPG-20 / 22 Butyl Ether Dimethicone, PEG / PPG-22 / 22 Butyl Ether Dimethicone, PEG / PPG-23 / 23 Butyl Ether Dimethicone, PEG / PPG-24 / 18 Butyl Ether Dimethicone, PEG / PPG-27 / 9 Butyl Ether Dimethicone, PEG / PPG-3 / 10 polydimethylsiloxane, PEG / PPG-4 / 12 polydimethylsiloxane, PEG / PPG-6 / 4 polydimethylsiloxane, PEG / PPG-6 / 11 polydimethylsiloxane, PEG / PPG-8 / 14 polydimethylsiloxane, PEG / PPG-8 / 26 polydimethylsiloxane, PEG / PPG-10 / 2 polydimethylsiloxane, PEG / PPG-12 / 16 polydimethylsiloxane,PEG / PPG-12 / 18 Dimethicone, PEG / PPG-14 / 4 Dimethicone, PEG / PPG-15 / 5 Dimethicone, PEG / PPG-15 / 15 Dimethicone, PEG / PPG-16 / 2 Dimethicone, PEG / PPG-16 / 8 Dimethicone, PEG / PPG-17 / 18 Dimethicone, PEG / PPG-18 / 6 Dimethicone, PEG / PPG-18 / 12 Dimethicone, PEG / PPG-18 / 18 Dimethicone, PEG / PPG-19 / 19 Dimethicone, PEG / PPG-20 / 6 Dimethicone, PE G / PPG-20 / 15 Dimethicone, PEG / PPG-20 / 20 Dimethicone, PEG / PPG-20 / 23 Dimethicone, PEG / PPG-20 / 29 Dimethicone, PEG / PPG-22 / 23 Dimethicone, PEG / PPG-22 / 24 Dimethicone, PEG / PPG-23 / 6 Dimethicone, PEG / PPG-25 / 25 Dimethicone, PEG / PPG-27 / 27 Dimethicone, PEG / PPG-30 / 10 Dimethicone, PEG / PPG-25 / 25 Dimethicone / Acrylic Acid Copolymer, PEG / PPG-2 0 / 22 Methyl Ether Dimethicone, PEG / PPG-24 / 24 Methyl Ether Glycidoxy Dimethicone, PEG / PPG-10 / 3 Oleyl Ether Dimethicone, PEG / PPG-5 / 3 Trisiloxane, PEG-4 Trifluoropropyl Dimethicone Copolymer, PEG-8 Trifluoropropyl Dimethicone Copolymer, PEG-10 Trifluoropropyl Dimethicone Copolymer, PEG-8 Trisiloxane, Perfluorooctyl Triethoxysilylethyl Methicone, Perfluorononyl Dimethicone, Perfluorononyl Dimethicone / Methicone / Amodimethicone Crosspolymer, Perfluorononyl Ethyl Carboxydecyl Behenyl Dimethicone, Perfluorononyl Ethyl carboxydecyl hexadecyl dimethicone, perfluorononylethyl carboxydecyl lauryl / behenyl dimethicone, perfluorononylethyl carboxydecyl lauryl dimethicone, perfluorononylethyl carboxydecyl PEG-8 dimethicone, perfluorononylethyl carboxydecyl PEG-10 dimethicone, perfluorononylethyl dimethicone / methicone copolymer, perfluorononylethyl PEG-8 dimethicone, perfluorononylethyl stearyl dimethicone, perfluorooctylethyl / diphenyl dimethicone copolymer, perfluorooctylethyl triethoxysilane, perfluorooctylethanol trimethoxysilane, perfluorooctylethyl trisiloxane, perfluorooctyl triethoxysilane, PG-amodimethicone,Phenyl Dimethicone, Phenyl Disiloxane, Phenyl Dimethicone, Phenyl Isopropyl Dimethicone, Phenyl Methicone, Phenyl Methiconol, Phenyl Propyl Dimethylsiloxysilicate, Phenyl Ethyl Methicone, Phenyl Propyl Trimethicone, Phenyl Propyl Trimethicone / Diphenyl Methicone, Phenyl Trimethicone, Divinyl Disiloxane Platinum, Polyacrylate-6, Polydiethylsiloxane, Polydimethylsiloxyethyl Dimethicone / Bis-Vinyl Dimethicone Crosspolymer, Polydimethylsiloxyethyl Dimethicone / Methicone Copolymer, Polydimethylsiloxy PEG / PPG-24 / 19 Butyl Ether Silsesquioxane, Polydimethylsiloxy PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-3 Disiloxane Dimethicone, Polyglyceryl-3 / Lauryl Dimethicone Ethyl Dimethicone Crosspolymer, Polyglyceryl-3 Dimethicone Ethyl Dimethicone, Poly(Ethylene Glycol Adipate) / Bis-Hydroxyethoxypropyl Dimethicone Copolymer, Polymethyl Silsesquioxane, Polymethyl Silsesquioxane / Trimethylsiloxysilicate, Polyphenyl Silsesquioxane, Polypropyl Silsesquioxane, Polysilicone-1, Polysilicone-2, Polysilicone-3, Polysilicone-4, Polysilicone-5, Polysilicone-6, Polysilicone-7, Polysilicone-8, Polysilicone-9, Polysilicone-10, Polysilicone-11, Polysilicone-1 2. Polysilicone-13, Polysilicone-14, Polysilicone-15, Polysilicone-16, Polysilicone-17, Polysilicone-18, Polysilicone-19, Polysilicone-20, Polysilicone-21, Polysilicone-18 Cetyl Phosphate, Polysilicone-1 Crosspolymer, Polysilicone-18 Stearate, Polyurethane-10, Methylsilicone PEG-7 Panthenol Phosphate Potassium, Polydimethylsilicone PEG-7 Phosphate Potassium, PPG-12 Butyl Ether Polydimethylsiloxane, PPG-2 Polydimethylsiloxane, PPG-12 Polydimethylsiloxane, PPG-27 Polydimethylsiloxane, PPG-4 Oleth-10 Polydimethylsiloxane, Propoxytetramethylpiperidinyl Polydimethylsiloxane , Propyl trimethicone, Quaternium-80, Retinyl trimethyl silane, Silanediol salicylate, Silanetriol, Silanetriol arginine ester, Silanetriol glutamate, Silanetriol lysine ester, Silanetriol melanin ester, Silanetriol trehalose ether, Silica, Polydimethylsiloxane silicylates, Silica dimethyl silylate, Silica silylate, Silicon carbide, Polysilicone quaternium-1, Polysilicone quaternium-2, Polysilicone quaternium-2 panthenol succinate, Polysilicone quaternium-3, Polysilicone quaternium-4, Polysilicone quaternium-5, Polysilicone quaternium-6, Polysilicone quaternium-7, Polysilicone quaternium-8, Polysilicone quaternium-9, Polysilicone quaternium-10,Polysilicone Quaternium-11, Polysilicone Quaternium-12, Polysilicone Quaternium-15, Polysilicone Quaternium-16, Polysilicone Quaternium-16 / Glycidoxy Dimethicone Crosspolymer, Polysilicone Quaternium-17, Polysilicone Quaternium-18, Polysilicone Quaternium-19, Polysilicone Quaternium-20, Polysilicone Quaternium-21, Polysilicone Quaternium-22, Polysilicone Quaternium-24, Polysilicone Quaternium-25, Siloxanetriol Alginate, Siloxanetriol Phytate, Silicone Resin, Sodium Carboxydecyl PEG-8 Polydimethicone, Sodium Dimethicone PEG-7 Acetyl Methyl Taurate, Sodium Dimethylsilanol Hyaluronate, Sodium Lactate Methylsilanol, Mannoaldehyde Sodium PCA Methicone, Sodium PCA Methicone, Sodium PG-Propyl Dimethicone Thiosulfate Copolymer, Sodium PG-Propyl Thiosulfate Dimethicone, Sodium Propoxy Hydroxypropyl Thiosulfate Silica, Sorbitan Silanediol, Soybean Triethoxysilylpropyl Dimonium Chloride, Stearalkonium Dimethicone PEG-8 Phthalate, Stearamidopropyl Dimethicone, Stearyl Dimonium Hydroxypropyl Panthenol PEG-7 Dimethicone Phosphate Chloride, Stearyl Dimonium Hydroxypropyl PEG-7 Dimethicone Phosphate Chloride, Stearyl Dimethicone, Stearyl Oxymethicone / Dimethicone Copolymer, Stearyl Trimethylsilane, Stearyl Aminopropyl Methicone Alkane, stearyl dimethicone, stearyl alcohol / lauryl methacrylate crosspolymer, stearyl polymethicone, stearyl triethoxysilane, stearyl trimethicone, styrene / acrylates / dimethicone acrylate crosspolymer, styrene / acrylates / dimethicone copolymer, dimethicone PEG-7 phosphate TEA salt, (tetrabutoxy)propyl trisiloxane, tetramethyl hexaphenyltetrasiloxane, tetramethyl tetraphenyl tripolysiloxane, tocopheryloxypropyl trisiloxane, trideceth-9PG-amodimethicone, triethoxycaprylylsilane, triethoxysilylethyl dimethicone / methicone copolymer, triethoxysilylethyl Polydimethylsiloxyethyl polydimethicone, triethoxysilylethyl polydimethylsiloxyethylhexyl polydimethicone, triethoxysilylpropylcarbamoylethoxypropylbutyl polydimethicone, trifluoromethyl C1-4 alkyl polydimethicone, trifluoropropyl cyclopentasiloxane, trifluoropropyl cyclotetrasiloxane, trifluoropropyl polydimethicone, trifluoropropyl polydimethicone / PEG-10 crosspolymer, trifluoropropyl polydimethicone / trifluoropropyl divinyl polydimethicone crosspolymer, trifluoropropyl polydimethicone / vinyl trifluoropropyl polydimethicone / silsesquioxane crosspolymer, trifluoropropyl polydimethicone alcohol, trifluoropropyl dimethyl / trimethylsiloxysilicate,Trifluoropropyl methicone, trimethoxycaprylylsilane, trimethoxysilyl dimethicone, trimethyl pentaphenyl trisiloxane, trimethylsiloxyamodimethicone, trimethylsiloxyphenyl dimethicone, trimethylsiloxysilicate, trimethylsiloxysilicate / dimethicone crosspolymer, trimethylsiloxysilicate / dimethiconol crosspolymer, trimethylsiloxysilylcarbamoyl pullulan, trimethylsilyl hydrolyzed conchiolin protein PG-propyl methylsilanediol crosspolymer, trimethylsilyl hydrolyzed silk PG-propyl methylsilanediol crosspolymer, trimethylsilyl hydrolyzed wheat protein PG-propyl methylsilanediol crosspolymer, Pullulan, trimethylsilanol trisiloxyglycolate, trimethylsilanol trisiloxylactate, trimethylsilanol trisiloxysalicylate, triphenyl trimethicone, trisiloxane, tris(tributoxysiloxy)methylsilane, undecene dimethicone, vinyl dimethicone, vinyl dimethicone / lauryl dimethicone crosspolymer, vinyl dimethicone / methicone silsesquioxane crosspolymer, vinyl dimethicone / trimethylsiloxysilicate / stearyl dimethicone crosspolymer, VP / dimethylaminoethyl methacrylate / polyethylene glycol polyurethane, zinc carboxydecyl trisiloxane and dimethicone PEG-8 zinc succinate and mixtures thereof. The silicones contained in the mixture according to the invention are more preferably dimethicone, cyclomethicone, phenyl trimethicone, cyclohexasiloxane and cyclopentasiloxane. A detailed description of suitable volatile silicone compounds is given in Todd et al. in Cosm. Toil. 91, 27 (1976).

[0077] Waxes and stabilizers

[0078] In addition to the natural oils used, the preparations may also contain waxes, in particular natural waxes such as, for example, candelilla wax, carnauba wax, Japan wax, espartograss wax, cork wax, guaruma wax, rice oil wax, sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax, spermaceti, wool wax, uropygial fat, ozokerite, ceresin (paraffin), vaseline, petroleum waxes and microwaxes; chemically modified waxes (hard waxes) such as, for example, montan ester waxes, sasol waxes, hydrogenated jojoba waxes and synthetic waxes such as, for example, polyalkylene waxes and polyethylene glycol waxes.

[0079] Metal salts of fatty acids, such as, for example, magnesium stearic acid or ricinoleate, aluminum and / or zinc salts can be used as stabilizers.

[0080] Main sunscreen agents

[0081] Essential sunscreens in the context of the present invention are, for example, organic substances which are liquid or crystalline at room temperature (light filters), which are able to absorb UV radiation and release the absorbed energy again in the form of long-wave radiation, for example heat.

[0082] The preparations according to the invention advantageously contain at least one UV-A filter and / or at least one UV-B filter and / or a broadband filter and / or at least one inorganic dye. The preparations according to the invention preferably contain at least one UV-B filter or a broadband filter, more particularly at least one UV-A filter and at least one UV-B filter.

[0083] The UV filter substances cited below that can be used in the present invention are preferred, but are not limited to these substances. The UV filter agents preferably used are selected from one, two, three, four, five or more of the following categories:

[0084]

[0085]

[0086] In a preferred embodiment, the sunscreen filters forming component (ii) represent a blend of UV-A and UV-B filters selected from the group consisting of homosalate, octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxydibenzoylmethane, ethylhexyl salicylate and mixtures thereof. Particularly preferred are mixtures of all these filters, which are available on the market under the trademark Flat (SYMRISE), which is also the subject of WO 2020 088778 A1.

[0087] Suitable pigments include oxides of titanium (TiO2), zinc (ZnO), iron (Fe2O3), zirconium (ZrO2), silicon (SiO2), manganese (e.g., MnO), aluminum (Al2O3), cerium (e.g., Ce2O3), and / or mixtures thereof.

[0088] In a further preferred embodiment, the preparations according to the invention comprise a total amount of sunscreens, ie in particular UV filters and / or inorganic pigments (UV filter pigments), such that the preparations according to the invention have a photoprotection factor of greater than or equal to 5 and at most 50. Such preparations according to the invention are particularly suitable for protecting the skin and hair.

[0089] Secondary sunscreen

[0090] In addition to the above-mentioned primary sunscreen groups, secondary sunscreens of the antioxidant type may also be used. Secondary sunscreens of the antioxidant type block the photochemical reaction chain initiated when ultraviolet rays penetrate into the skin. Typical examples are amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and its glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, α-linoleoyl, cholesteryl and their glycerides) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and very low tolerance doses of sulfoximine compounds (e.g. buthionine sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, penta-, hexa- and heptathionine sulfoximine), and (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids , citric acid, lactic acid, malic acid), humic acid, bile acid, bile extract, bilirubin, biliverdin, EDTA, EGTA and its derivatives, unsaturated fatty acids and their derivatives (such as linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and its derivatives (such as ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherol and its derivatives (such as vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), as well as benzoyl benzoate of benzoin resin, rutin and its derivatives, glycosyl rutin, ferulic acid, fusin The invention also includes the following: sorbitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiaretic acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, titanium dioxide (for example, dispersion in ethanol), zinc and its derivatives (for example, ZnO, ZnSO4), selenium and its derivatives (for example, methionine selenium), stilbenes and their derivatives (for example, stilbene oxide, trans-stilbene oxide) and derivatives of these active compounds suitable for the purposes of the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids).

[0091] Advantageous inorganic secondary light protection pigments are finely dispersed metal oxides and metal salts, which are also mentioned in WO 2005 123101 A1. The total amount of inorganic pigments, in particular hydrophobic inorganic micropigments, in the finished cosmetic preparations according to the invention is advantageously 0.1 to 30% by weight, preferably 0.5 to 10.0% by weight, in each case based on the total weight of the preparation.

[0092] Also preferred are particulate UV filters or inorganic pigments, which may optionally be hydrophobized, for example oxides of titanium (TiO2), zinc (ZnO), iron (Fe2O3), zirconium (ZrO2), silicon (SiO2), manganese (e.g. MnO), aluminum (Al2O3), cerium (e.g. Ce2O3) and / or mixtures thereof.

[0093] Biologics and Antioxidants

[0094] Biologically active substances include, for example, tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, (deoxy)ribonucleic acid and its fragmentation products, β-glucan, retinol, bisabolol, allantoin, phytantriol, panthenol, AHA acid, amino acids, ceramides, pseudoceramides, essential oils, plant extracts, such as plum extract, bambaranus extract and vitamin complexes.

[0095] Antioxidants block the photochemical reaction chain initiated when UV rays penetrate into the skin. Typical examples are amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, pentyl , butyl and lauryl, palmitoyl, oleyl, α-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and very low tolerable doses (pmol to mol / k) of sulfoximine compounds (e.g. buthionine sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, penta-, hexa- and heptathionine sulfoximine), and (metal) chelators (e.g. hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin) , hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and its derivatives (e.g. ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherol and its derivatives (e.g. vitamin E acetate), vitamin A and its derivatives (vitamin A palmitate), as well as benzoyl benzoate of benzoin resin, rutin and its derivatives , glycosyl rutin, ferulic acid, furfurylidene sorbitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiaretic acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, zinc and its derivatives (e.g. ZnO, ZnSO4), selenium and its derivatives (e.g. methionine selenium), stilbenes and their derivatives (e.g. stilbene oxide, trans-stilbene oxide) and derivatives of these active compounds suitable for the purposes of the present invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids).

[0096] Active substances that regulate hair pigmentation

[0097] Preferred active ingredients for hair lightening are selected from the group consisting of: kojic acid (5-hydroxy-2-hydroxymethyl-4-pyrone), kojic acid derivatives, preferably kojic acid dipalmitate, arbutin, ascorbic acid, ascorbic acid derivatives, preferably magnesium ascorbyl phosphate, hydroquinone, hydroquinone derivatives, resorcinol, resorcinol derivatives, preferably 4-alkylresorcinol and 4-(1-phenylethyl)1,3-resorcinol (phenethylresorcinol), cyclohexylcarbamates (preferably WO 2010 / 122178 and WO2010 / 097480), sulfur-containing molecules, preferably glutathione or cysteine, α-hydroxy acids (preferably citric acid, lactic acid, malic acid), their salts and esters, N-acetyl tyrosine and derivatives, undecylenoyl phenylalanine, gluconic acid, chromone derivatives, preferably aloesin, flavonoids, 1-aminoethylphosphinic acid, thiourea derivatives, ellagic acid, niacinamide, zinc salts, preferably zinc chloride or zinc gluconate, thujacin and derivatives, triterpenes, preferably maslinic acid, sterols, preferably ergosterol, benzofuranones, preferably ligustolide, vinyl guaiacol, ethyl guaiacol, dionic acids (dionic acids), preferably octadecene dioic acid and / or azelaic acid, inhibitors of nitrogen oxide synthesis, preferably L-nitroarginine and its derivatives, 2,7-diindazole or thiocitrulline, metal chelators (preferably α-hydroxy fatty acids, phytic acid, humic acid, bile acid, bile extracts, EDTA, EGTA and their derivatives), retinoids, soy milk and extracts, serine protease inhibitors or lipoic acid or other synthetic or natural active ingredients for skin and hair lightening, the latter preferably in the form of extracts from plants, preferably bearberry extract, rice extract, papaya extract, turmeric extract, mulberry extract, jasmine extract, cyperus rotundus extract, liquorice root extract or components concentrated or isolated therefrom, preferably glabridin or licochalcone A, jackfruit extract, Rumex and Uncaria rhynchophylla extracts, extracts of Pinus (pine), extracts of Vitis or stilbene derivatives isolated or concentrated therefrom, Saxifraga extract, Scutellaria baicalensis extract (scutelleria extract), grape extract and / or microalgae extract, in particular Tetrascelis quadriscapularis extract.

[0098] Skin and hair tanning active ingredients which are advantageous in this context are substrates or substrate analogs for tyrosinase, such as L-tyrosine, N-acetyltyrosine, L-DOPA or L-dihydroxyphenylalanine, xanthine alkaloids, such as caffeine, theobromine and theophylline and their derivatives, proopiomelanocortin peptides, such as ACTH, α-MSH, their peptide analogs, and other substances which bind to melanocortin receptors, peptides, pyrimidine compounds, folic acid, copper salts, such as copper gluconate, chlorides, copper pyrrolidone or copper pyrrolidone, 1,3,4-oxadiazole-2-thiol such as 5-pyrazin-2-yl-1,3,4-oxadiazole-2-thiol, curcumin, zinc diglycinate (Zn(Gly)2)), manganese(II) dicarbonate complexes ("pseudocat-alases"), as described, for example, in EP0584178, tetrasubstituted cyclohexene derivatives, as described, for example, in WO2005 / 032501, isoprenoids, as described in WO 2005 / 102252 and WO2006 / 010661, melanin derivatives such as Melasyn-100 and MelanZe, diacylglycerols, aliphatic or cyclic diols, psoralens, prostaglandins and their analogs, activators of adenylate cyclase and compounds that activate the conversion of hair melanosomes into keratinocytes, such as serine proteases or PAR-2 ​​receptor agonists, extracts of plants and plant parts of the genus Chrysanthemum, extracts of plants and plant parts of the genus Sanguisorba, walnut extracts, urucum extracts, rhubarb extracts, microalgae extracts, especially Isochrysis galbana, trehalose, erythrulose and dihydroxyacetone. Flavonoids that cause skin and hair staining or browning (e.g., quercetin, rhamnosine, kaempferol, fisetin, genistein, daidzein, chrysin and apigenin, epicatechin, diosgenin and geranyl, morin, quercetin, naringenin, hesperidin, phloridzin, phloretin) may also be used.

[0099] The amount of the aforementioned examples of further active ingredients (one or more compounds) for regulating skin and hair pigmentation in the products according to the invention is preferably from 0.00001 to 30% by weight, preferably from 0.0001 to 20% by weight, particularly preferably from 0.001 to 5% by weight, based on the total preparation.

[0100] Hair growth activators or inhibitors

[0101] Preparations and products according to the invention may also contain one or more hair growth activators, ie preparations which stimulate hair growth. The hair growth activator is preferably selected from the group consisting of pyrimidine derivatives, such as 2,4-diaminopyrimidine-3-oxide (Aminexil), 2,4-diamino-6-piperidopyrimidine-3-oxide (Minoxidil) and its derivatives, 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidopyrimidine and its derivatives, xanthine alkaloids, such as caffeine, theobromine and theophylline and their derivatives, quercetin and derivatives, dihydroquercetin (taxifolin) and derivatives, potassium channel openers, antiandrogens, synthetic or natural 5-reductase inhibitors, nicotinates, such as tocopheryl nicotinate, benzyl nicotinate and C1-C6 alkyl nicotinates, proteins such as the tripeptide Lys-Pro-Val, diphencypren, hormones, finasteride, dutasteride, flutamide, bicalutamide, pregnane derivatives, progesterone and its derivatives, cyproterone acetate ketones, spironolactone and other diuretics, calcineurin inhibitors such as FK506 (Tacrolimus, Fujimycin) and their derivatives, cyclosporin A and its derivatives, zinc and zinc salts, polyphenols, proanthocyanidins, proanthocyanidins, phytosterols such as β-sitosterol, biotin, eugenol, (±)-β-citronellol, panthenol, glycogen, for example from mussels, from microorganisms, from seaweed, Extracts of plants and plant parts, for example plants of the genera: dandelion (genus Leontopodium or Taraxacum), Codonopsis pilosula, Vitex, coffee, Paulownia oleracea, cocoa, Asarum gracile, Cucurbita spp. or Sophora japonica, Serenoa repens (Saw Palmetto), Sophora flavescens, Pygeum africanum, Panicum foetida, Cimicifuga foetida, Soybean, Clove, Cotinus coggygria, Hibiscus rosa-sinensis, Camellia sinensis, Yerba mate, Isochrysis galbana, Licorice, grape, apple, barley or hops, or / and rice or wheat hydrolysates.

[0102] Optionally, the preparations and products according to the invention may also contain one or more hair growth inhibitors (as described above), i.e. preparations that slow down or prevent hair growth. The hair growth inhibitors are preferably selected from the group consisting of activin, activin derivatives or activin agonists, ornithine decarboxylase inhibitors, such as α-difluoromethylornithine or pentacyclic triterpenoids such as ursolic acid, betulin, betulinic acid, oleanolic acid and its derivatives, 5α-reductase inhibitors, androgen receptor antagonists, S-adenosylmethionine decarboxylase inhibitors, γ-glutamyl transpeptidase inhibitors, transglutaminase inhibitors, serine protease inhibitors of soybean origin, extracts from microorganisms, seaweed, different microalgae or plants and plant parts, such as Leguminosae, Solanaceae, Gramineae, Asclepiadaceae or Cucurbitaceae, Chondrus, Hemerocallis, Ceropegia, Dulvilla, Glycine max, Sanguisorba officinalis, Calendula, Hamamelis, Arnica montana, Salix alba, Hypericum perforatum or Gymnema sylvestre.

[0103] Physiological cooling and warming agents

[0104] Physiological cooling agents are preferably selected from the classes described in the following table (including their optical isomers and racemates):

[0105]

[0106]

[0107] The physiological warming agent may be selected from the group consisting of capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, N-vanillyl nonivamide and chili pepper extract.

[0108] Anti-inflammatory agents

[0109] Suitable anti-inflammatory agents are selected from the group consisting of:

[0110] (i) steroidal anti-inflammatory substances of the corticosteroid class, in particular hydrocortisone, hydrocortisone derivatives such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone,

[0111] (ii) nonsteroidal anti-inflammatory substances, in particular oxoxicam such as piroxicam or tenoxicam, salicylates such as aspirin, salsalate, solprin or fendosal, acetic acid derivatives such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin or clindanac, fenamic acid esters such as mefenamic acid, meclofenamic acid, flufenamic acid or niflumic acid, propionic acid derivatives such as ibuprofen, naproxen or benoxaprofen, pyrazoles such as phenylbutazone, oxyphenbutazone, febrazone or azapropazone,

[0112] (iii) natural or naturally occurring anti-inflammatory substances or substances which relieve redness and / or itching, in particular extracts or fractions of camomile, aloe, myrrh, madder, willow, willowherb, oats, calendula, arnica, St John's wort, honeysuckle, rosemary, passion flower (Passiflora incarnata), witch hazel, ginger or echinacea, or the single active compounds thereof,

[0113] (iv) histamine receptor antagonists, serine protease inhibitors (e.g. soybean extract), TRPV1 antagonists (e.g. 4-tert-butylcyclohexanol), NK1 antagonists (e.g. aprepitant, hydroxyphenylpropionamide benzoic acid), cannabinoid receptor agonists (e.g. palmitoylethanolamine) and TRPV3 antagonists.

[0114] Antimicrobial Agents

[0115] Suitable antimicrobial agents are theoretically all substances that are able to combat Gram-positive bacteria, such as, for example, 4-hydroxybenzoic acid and its salts and esters, N-(4-chlorophenyl)-N′-(3,4-dichlorophenyl)urea, 2,4,4′-trichloro-2′-hydroxy-diphenyl ether (triclosan), 4-chloro-3,5-dimethyl-phenol, 2,2′-methylenebis(6-bromo-4-chlorophenol), 3-methyl-4-(1-methylethyl)phenol, 2-benzyl-4-chloro-phenol, 3-(4 -chlorophenoxy)-1,2-propanediol, 3-iodo-2-propynylcarbamic acid butyl ester, chlorhexidine, 3,4,4'-trichlorocarbanilide (TTC), antibacterial fragrance, thymol, thyme oil, eugenol, clove oil, menthol, peppermint oil, farnesol, phenoxyethanol, glyceryl monocaprate, glyceryl monocaprylate, glyceryl monolaurate (GML), diglyceryl monocaprate (DMC), salicylic acid N-alkyl amides, for example, n-octyl salicylic acid amide or n-decyl salicylic acid amide.

[0116] Enzyme inhibitors

[0117] Suitable enzyme inhibitors are, for example, esterase inhibitors. These enzyme inhibitors are preferably trialkyl citrates, such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and, in particular, triethyl citrate (HydagenCAT). These substances can inhibit the activity of the enzyme, thereby reducing the formation of odors. Other substances suitable as esterase inhibitors are sterol sulfates or phosphates, for example, lanosterol sulfate or phosphate, cholesterol sulfate or phosphate, campesterol sulfate or phosphate, stigmasterol sulfate or phosphate and sitosterol sulfate or phosphate; dicarboxylic acids and esters thereof, for example glutaric acid, monoethyl glutarate, diethyl glutarate, adipic acid, monoethyl adipate, diethyl adipate, malonic acid and diethyl malonate, hydroxycarboxylic acids and esters thereof, for example citric acid, malic acid, tartaric acid or diethyl tartrate, and zinc glycinate.

[0118] Odor absorbers and antiperspirant actives

[0119] Suitable odor absorbers are substances that can absorb and retain to a large extent the compounds that form the taste. They reduce the partial pressure of each component, thereby also reducing its diffusion rate. It is important that the fragrance must remain intact during this process. Odor absorbers have no effect on bacteria. They contain, for example, a composite zinc salt of ricinoleic acid as a main component, or a specific fragrance that is known to those skilled in the art as a "fixing agent" and mainly neutralizes the odor, for example, an extract of rock rose or styrax or some rosin acid derivatives. Odor masking agents are fragrances or fragrance oils that, in addition to their function as odor masking agents, also provide their respective fragrances to the deodorant. Fragrance oils that can be mentioned are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers, stems and leaves, fruits, peels, roots, wood, herbs and grasses, pine needles and branches, as well as resins and balsams. Also suitable are animal products, such as civet and castoreum. Typical synthetic aromatic compounds are esters, ethers, aldehydes, ketones, alcohols and hydrocarbon products. Ester fragrance compounds are, for example, benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allyl cyclohexylpropionate, styroyl propionate and benzyl salicylate. Ethers include, for example, benzyl ethyl ether; aldehydes include, for example, linear alkanals containing 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lily aldehyde and bourgeonal; ketones include, for example, ionone and methyl cedryl ketone; alcohols include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol; hydrocarbons mainly include terpenes and balsams. However, it is preferred to use a mixture of different fragrances, which together produce a pleasant fragrance. Less volatile essential oils commonly used as fragrance ingredients are also suitable as fragrance oils, such as sage oil, chamomile oil, clove oil, melissa oil, peppermint oil, cinnamon leaf oil, linden flower oil, juniper berry oil, vetiver oil, frankincense oil, galbanum oil, labdanum oil, and lavender oil.Preference is given to using bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamen aldehyde, linalool, boisambrene forte, ambroxan, indole, methyl dihydrojasmonate, sandelice, lemon oil, mandarin oil, orange oil, allyl isopentoxyacetate, cyclovertal, lavender oil, clary sage oil, β-damascenone, bourbon geranium oil, cyclohexyl salicylate, Vertofixcoeur, iso-E-super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilat, 2-ethyl-hexanoic acid ethyl ester (irotyl) and 2-tert-butylcyclohexylethyl carbonate (floramat), alone or in a mixture.

[0120] Suitable astringent antiperspirant active ingredients are primarily salts of aluminum, zirconium or zinc. Suitable antihydrotic active ingredients of this type are, for example, aluminum chloride, aluminum hydrochlorate, aluminum dihydrochlorate, aluminum sesquichlorate and complexes thereof, for example with 1,2-propylene glycol, aluminum hydroxyallantoinate, aluminum chlorotartrate, aluminum zirconium trihydrochloride, aluminum zirconium tetrahydrochloride, aluminum zirconium pentahydrochloride and complexes thereof, for example with amino acids such as glycine.

[0121] Film formers and anti-dandruff agents

[0122] Standard film formers are, for example, chitosan, microcrystalline chitosan, quaternary chitosan, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, acrylic polymers, quaternary cellulose derivatives, collagen, hyaluronic acid and its salts and similar compounds.

[0123] Suitable antidandruff agents are Pirocton Olamin (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridinone monoethanolamine salt), (Climbazole), (4-acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1H-imidazol-1-ylmethyl)-1,3-dioxylan-c-4-ylmethoxyphenyl}-piperazine, ketoconazole, neoconazole, selenium disulfide, colloidal sulfur, sulfur polyethylene glycol dehydrated sorbitan monooleate, sulfur ricinole polyethoxylate, sulfur tar fraction, salicylic acid (or combined with hexachlorophene), undecylenic acid, monoethanolamide sulfosuccinic acid sodium salt, UD (protein / undecylenic acid concentrate), zinc pyrithione, aluminum pyrithione, and magnesium pyrithione / dipyrithione magnesium sulfate.

[0124] Carriers and hydrotropes

[0125] Preferred cosmetic carrier materials are solid or liquid (including high viscosity substances) at 25° C. and 1013 mbar, such as glycerol, 1,2-propylene glycol, 1,2-butylene glycol, 1,3-propylene glycol, 1,3-butylene glycol, ethanol, water and mixtures of two or more of the liquid carrier substances and water. Optionally, these preparations of the present invention can be prepared using preservatives or cosolvents. Other preferred liquid carrier substances that can be used as ingredients of the preparations of the present invention are selected from the group consisting of oils, such as vegetable oils, neutral oils and mineral oils.

[0126] Preferred solid carrier substances which can be used as components of the preparations according to the invention are hydrocolloids, for example starch, degraded starch, chemically or physically modified starch, dextrin, (powdered) maltodextrin (preferably with a dextrose value of 5 to 25, preferably 10-20), lactose, silicon dioxide, glucose, modified cellulose, gum arabic, gum ghatti, gum traganth, gum karaya, carrageenan, pullulan, curdlan, xanthan gum, gellan gum, guar gum, carob powder, alginates, agar, pectin and inulin and mixtures of two or more of these solid substances, in particular maltodextrin (preferably with a dextrose value of 15 to 20), lactose, silicon dioxide and / or glucose.

[0127] In addition, hydrotropes, such as ethanol, isopropanol or polyols, can be used to improve fluidity. Suitable polyols preferably contain 2 to 15 carbon atoms and at least two hydroxyl groups. Such polyols may contain other functional groups, more specifically amino groups, or may be nitrogen-modified. Typical examples are:

[0128] ·glycerin;

[0129] Alkanediols, for example ethylene glycol, diethylene glycol, propylene glycol, butanediol, hexanediol and polyethylene glycols having an average molecular weight of 100 to 1000 daltons;

[0130] Technical oligoglycerol mixtures having a degree of self-condensation of 1.5 to 10, such as technical diglycerol mixtures having a diglycerol content of 40 to 50% by weight;

[0131] methylol compounds, in particular, for example trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol;

[0132] lower alkyl glycosides, especially those containing 1 to 8 carbon atoms in the alkyl group, for example methyl glycoside and butyl glycoside;

[0133] Sugar alcohols containing 5 to 12 carbon atoms, such as sorbitol or mannitol;

[0134] Sugars containing 5 to 12 carbon atoms, such as glucose or sucrose;

[0135] Amino sugars, such as glucosamine;

[0136] - Diolamines, for example diethanolamine or 2-aminopropane-1,3-diol.

[0137] Preservatives and / or product protectants

[0138] Suitable preservatives are listed in Appendix 6 Parts A and B of the Kosmetikverordnung ("Cosmetics Directive").

[0139] Suitable species may be selected from preservatives selected from the group consisting of benzoic acid and p-hydroxybenzoic acid, their esters and salts, benzyl benzoate, propionic acid and its salts, salicylic acid and its salts, 2,4-hexadienoic acid (sorbic acid) and its salts, levulinic acid and its salts, anisic acid and its salts, perillic acid and its salts, cinnamic acid and its salts, formaldehyde and paraformaldehyde, 4-hydroxybenzaldehyde, o-, m- and p-anisaldehyde, cinnamaldehyde, cinnamyl alcohol, 2-hydroxybiphenyl ether and its salts, 2-zinc-thiopyridine N-oxide, inorganic sulfites and bisulfites, sodium iodate, chlorobutanol, 4-ethylmercury-(II) 5-amino-1,3-bis(2 -hydroxybenzoic acid), its salts and esters, dehydrated acetic acid, formic acid, 1,6-bis(4-amidino-2-bromophenoxy)-n-hexane and its salts, sodium salt of ethylmercury(II)-thiosalicylic acid, phenylmercury and its salts, 10-undecenoic acid and its salts, 5-amino-1,3-bis(2-ethylhexyl)-5-methyl-hexahydropyrimidine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitro-1,3-propanediol, 2,4-dichlorobenzyl alcohol, N-(4-chlorophenyl)-N′-(3,4-dichlorophenyl)urea, 4-chloro-m-cresol, 2,4,4′-trichloro-2′-hydroxy-di phenyl ether, 4-chloro-3,5-dimethylphenol, 1,1′-methylene-bis(3-(1-hydroxymethyl-2,4-dioxoimidazolidin-5-yl)urea), poly-(hexamethylene biguanide) hydrochloride, (benzyloxymethoxy)-methanol, hexamethylenetetramine, 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, 1,3-bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, 1, 2-Dibromo-2,4-dicyanobutane, 2,2′-methylene-bis(6-bromo-4-chloro-phenol), bromochlorobenzene, 5-chloro-2-methyl-3(2H)-isothiazolinone and a mixture of 2-methyl-3(2H)-isothiazolinone with magnesium chloride and magnesium nitrate, 2-octyl-2H-isothiazol-3-one, 1,2-benzisothiazol-3(2H)-one, 2-benzyl-4-chlorophenol, 3-(4-chlorophenoxy)-1,2-propanediol (Chlorphenesin), 2-chloroacetamide, chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, N-alkyl(C 12 -C 22 )trimethylammonium bromide and N-alkyl (C 12 -C 22)trimethyl-ammonium chloride, 4,4-dimethyl-1,3-oxazolidine, N-hydroxymethyl-N-(1,3-bis(hydroxymethyl)-2,5-dioxoimidazolin-4-yl)-N′-hydroxymethylurea, 1,6-bis(4-carbamimidoyl-phenoxy)-n-hexane and its salts, glutaraldehyde, 5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0)octane, 3-(4-chlorophenoxy)-1,2-propanediol, hyamines, alkyl-(C8-C 18 )-dimethyl-benzylammonium chloride, alkyl-(C8-C 18 )-dimethyl-benzylammonium bromide, alkyl-(C8-C 18)-dimethyl-benzylammonium saccharide, benzyl hemiformal, 3-iodo-2-propynyl butylcarbamate, sodium hydroxymethyl-aminoacetate or sodium hydroxymethyl-aminoacetate, imidazolidinyl urea, diazolidinyl urea, sodium hydroxymethylglycinate, DMDM ​​hydantoin, tropolone, (ethylenedioxy)dimethanol, 2-bromo-2-(bromomethyl)valeronitrile, N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine, α,α′,α″-trimethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol, pyridine-2-thiol-1-oxide, sodium salt, tetrahydro-1,3,4,6-tetra(hydroxymethyl)imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, 1,3-bis(hydroxymethyl)-1-(1,3,4-tri(hydroxy-methyl)-2,5-dioxoimidazolidin-4-yl)urea (bisimidazole urea), 1,3-bis(hydroxy-methyl)-5,5-dimethylimidazolidine-2,4-dione, 3-acetyl-2-hydroxy-6-methyl-4H-pyran-4-one, hexadecylpyridinium chloride, octanoylhydroxamic acid, sorbitol hydroxamic acid (sorbohydroxamic acid acid) and mixtures thereof, 1,3-propylene glycol, methylpropylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,2-decanediol, ethylhexylglycerol, hexyloxy-propane-1,2-diol, heptyloxy-propane-1,2-diol, octyloxy-propane-1,2-diol, 3-phenoxy-propane-1,2-diol, 3-benzyloxy-propane-1,2-diol, 3-phenylethoxy-propane-1,2-diol, 3-phenylpropoxy-propane-1,2-diol, 3-methylbenzyloxy-propane-1,2-diol, sorbitan octanoate, triclosan, clofenazole, Octopirox (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone, 2-aminoethanol), chitosan, farnesol, 2-butyloctanoic acid, 2-benzylheptan-1-ol, glycerol monolaurate, bis(2-pyridylthio)zinc 1,1′-dioxide, N,N′-(decylidene 1,10-diylpyridin-1-yl-4-ylidene)-dioctane-1-amine dihydrochloride (octenidine dihydrochloride), thymol, eugenol, benzyl alcohol, 2-phenylethanol, 3-phenylpropanol, 2-phenoxyethanol, 1-phenoxy-propan-2-ol, 3-phenoxypropanol, benzyloxymethanol, 4-hydroxyacetophenone and mixtures thereof.

[0140] Fragrance Oil

[0141] Suitable fragrance oils are mixtures of natural and synthetic fragrances. Natural fragrances include extracts of flowers (lily, lavender, rose, jasmine, orange blossom, ylang-ylang), stems and leaves (geranium, patchouli, bitter orange), fruits (fennel, coriander, caraway, juniper), peels (bergamot, lemon, orange), roots (nutmeg, angelica, celery, cardamom, costus, iris, calamus), wood (pine, sandalwood, guaiac, cedar, mahogany), herbs and grasses (tarragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, dwarf pine), resins and balsams (galbanum, elemi, benzoin, myrrh, frankincense, opoponax). Animal raw materials, such as civet and castoreum, can also be used.

[0142] Woody spices

[0143] Suitable woody fragrances are selected from the group consisting of:

[0144]

[0145]

[0146] Amber scented fragrance

[0147] Suitable fragrances having an amber smell are selected from the group consisting of:

[0148]

[0149] Fruity aroma spices

[0150] Suitable fragrances having a fruity aroma are selected from the group consisting of:

[0151]

[0152]

[0153] Musky scent

[0154] Suitable perfumes having a musky odor are selected from the group consisting of:

[0155]

[0156] dye

[0157] Suitable dyes are, for example, the publication "Kosmetische Verlag Chemie, Weinheim, 1984, any of the substances listed as suitable and approved for use in cosmetics on pages 81 to 106. Examples include carmine A (CI 16255), patent blue V (CI 42051), indigo (CI 73015), chlorophyllin (CI 75810), quinoline yellow (CI 47005), titanium dioxide (CI 77891), indanthrene blue RS (CI 69800) and madder red (CI 58000). Luminol can also be used as a fluorescent dye. Advantageous coloring pigments are, for example, titanium dioxide, mica, iron oxides (e.g., Fe2O3, Fe3O4, FeO(OH)) and / or tin oxide. Advantageous dyes are, for example, carmine, Berlin blue, chromium oxide green, ultramarine and / or manganese violet.

[0158] preparation

[0159] Preferred compositions according to the invention are chosen from products for treating, protecting, caring for and cleansing the skin and / or hair or as make-up products, preferably as leave-on products.

[0160] Products (meaning that one or more compounds remain on the skin and / or hair for a longer period of time than in rinse-off products).

[0161] The preparations according to the invention are preferably in the form of emulsions, for example W / O (water-in-oil), O / W (oil-in-water), W / O / W (water-in-oil-in-water), O / W / O (oil-in-water-in-oil) emulsions, PIT emulsions, Picking emulsions, emulsions with a low oil content, microemulsions or nanoemulsions, solutions, for example in oils (fatty oils or fatty acid esters, in particular C6-C32 fatty acid C2-C30 esters) or silicone oils, dispersions, suspensions, creams, emulsions or milks, depending on the preparation method and the ingredients, gels (including hydrogels, hydrodispersible gels, oleogels), sprays (for example pump sprays or sprays containing propellants) or foams or impregnating solutions for wipe-off cosmetics, detergents, for example soaps, synthetic detergents, washing liquids, shower and bath preparations, bath products (capsules, oils, tablets, salts, bath salts, soaps, etc.); effervescent preparations, skin care products such as emulsions (as described above), ointments , pastes, gels (as above), oils, balms, serums, powders (e.g. face powders, body powders), perfumes, eau de toilette, aftershaves, facial masks, eyebrow pencils, lipsticks, roll-ons, pumps, aerosols (foaming, non-foaming or post-foaming), deodorants and / or antiperspirants, mouthwashes and mouth rinses, foot care products (including exfoliants, deodorants), insect repellents, sunscreens, after-sun products, shaving products, aftershave balms, pre-shave and after-shave washes, depilatories, hair care Products such as shampoos (including 2-in-1 shampoos, anti-dandruff shampoos, baby shampoos, shampoos for dry hair, concentrated shampoos), conditioners, hair tonics, hair tonics, hair dyes, styling creams, pomades, perms and curling lotions, hair sprays, styling aids (such as gels or waxes), hair smoothing agents (conditioners, relaxers), hair dyes such as short-term direct hair dyes, semi-permanent hair dyes, permanent hair dyes, conditioners, hair mousses, eye care products, make-up, make-up removers or baby products.

[0162] The content of auxiliary substances and additives is 5 to 99% by weight, preferably 10 to 80% by weight, based on the total amount of the preparation. The amount of cosmetic or skin care product auxiliary agents and additives and fragrances used in each case can be easily determined by a simple trial and error method according to the properties of the specific product by a skilled person in the art.

[0163] The formulation may also contain up to 99% by weight, preferably about 5 to about 80% by weight and more preferably about 10 to about 50 or about 60 to about 80% by weight water, based on the total weight of the formulation.

[0164] drug

[0165] Another object of the present invention relates to the carnosine compound according to formula (I) as a drug for preventing, alleviating and / or treating human skin disorders or related functional disorders induced by enhanced PTGS2 expression.

[0166] In a preferred embodiment, the carnosine compound is L-carnosine.

[0167] In another preferred embodiment, the skin disorder is selected from inflammation, aging and / or skin cancer.

[0168] In another preferred embodiment, the associated functional disorder is selected from fever and / or pain.

[0169] Preferably, the carnosine is formulated as a cream, lotion, ointment or spray. In another advantageous embodiment, the cream, lotion, ointment or spray also contains at least one primary and / or secondary sun protection factor.

[0170] In order to maintain a good order, it is explicitly pointed out that all preferred embodiments, compounds, compositions and ranges related to the method of the invention also apply to the medicament as defined above. Therefore, any repetition is superfluous. Example

[0171] ___________________________________________________________

[0173] Experimental design

[0175] To evaluate the efficacy of L-carnosine in protecting the skin against solar simulated radiation (SSR), the gene expression and protein levels of PTGS2 were analyzed. Ex vivo human skin biopsies were topically treated with different concentrations (0.2% and 2.2%) of L-carnosine and exposed daily to 250 J / cm 2 Gene expression and protein regulation were assessed on days 2 and 3, respectively. The radiation dose was chosen based on the literature [11-13] to represent the approximate amount of sunlight that can be obtained through solarium under natural conditions.

[0176] Tissue culture

[0177] Human skin samples were obtained from healthy patients (aged between 25 and 60 years) undergoing plastic surgery and not exposed to strong sunlight. Informed consent was obtained from the patients and retained by the clinic. Twelve puncture biopsy samples with a diameter of 8 mm were used for each treatment in the study. Skin samples were cultured in an air-liquid interface of modified Williams' E medium and kept in an incubator under the following conditions: 37°C, 5% CO2 and 95% humidity.

[0178] deal with

[0179] In these studies, L-carnosine was dissolved in a vehicle (DMSO / PBS 1:25) at concentrations of 0.2% and 2.2%. Treatments were applied topically and renewed daily as follows: skin biopsy specimens were cleaned with a sterile cotton swab and 4 μl of treatment was applied to the biopsy epidermis. All treated and control samples were covered with a 6 mm diameter delivery membrane.

[0180] Simulated Solar Radiation (SSR)

[0181] Skin irradiation was performed daily using a Suntest XLS+ (Ametek Inc., USA) equipped with the provided infrared filter and daylight filter to obtain an emission spectrum between 300 and 800 nm. 250 J / cm 2 Skin samples were irradiated with SSR doses of 1.5 mmol / l and 1.5 mmol / l respectively. Control samples were sham irradiated under the same conditions.

[0182] Gene expression analysis

[0183] Human skin biopsy samples were collected in cryovials containing a commercial RNA stabilization solution (RNAlater, Merck KGaA, Germany) and stored at −80°C. Total RNA was extracted using a commercial kit (Rneasymini-kit, Qiagen GmbH, Germany) according to the manufacturer’s instructions. Real-time RT-PCR and custom-designed gene arrays ( Array96-Well Fast Plates, Thermo Fisher Scientific Inc., USA) were used to determine the expression levels of selected genes. Gene expression changes were determined in experimental samples compared to non-irradiated controls, and values ​​were expressed as fold changes relative to controls (fold change control = 1; fold change up-regulation level > 2).

[0184] Immunohistochemical staining

[0185] Skin samples were collected (day 3), fixed with formalin and embedded in paraffin. Skin sections were immunostained with PTGS2 antibody (ThermoFisher Scientific Inc., USA). Skin section images were acquired and analyzed by Image-J application (NIH, USA).

[0186] Example 1

[0188] PTGS2 gene expression level

[0189] Gene expression changes were determined in three donors. For each donor, the experimental sample was compared with the non-irradiated vehicle (control), and the values ​​were expressed as fold changes relative to the control (fold change control = 1.0; fold change up-regulation level > 2, statistical significance Δ ≥ 0.5). The results are shown in Table 1 and Table 2.

[0190] Table 1 PTGS2 gene expression in three donors

[0191]

[0192]

[0193] Table 2 Summary

[0194]

[0195] The results showed that L-carnosine reduced the expression of PTGS2 and provided photoprotection to cells. Figure 1a-1c The results are further explained.

[0196] Example 2

[0198] PTGS2 protein levels

[0199] Table 2 PTGS2 protein levels

[0200]

[0201]

[0202] Nd = Undetermined

[0203] The results showed that L-carnosine could effectively reduce SSR-induced PTGS2 gene and PTGS2 protein. This result suggests that L-carnosine can reduce PTGS2-induced skin disorders and related functional impairments.

[0204] Figure 2 The results are further explained.

[0205] References

[0206]

[11] Liebel F, Kaur S, Ruvolo E, et al. (2012) Irradiation of Skin withVisible Light Induces Reactive Oxygen Species and Matrix-Degrading Enzymes. JInvest Dermatol 132: 1901-1907.

[0207]

[12] Mahmoud B,Ruvolo E,Hexsel C,et al(2010)Impact of long-wavelengthUVA and visible light on melanocompetent skin.J Invest Dermatol 130(8):2092-7.

[0208]

[13] Vandersee S,Beyer M,Lademann J,et al(2015)Blue-Violet LightIrradiation Dose Dependently Decreases Carotenoids in Human Skin,WhichIndicates the Generation of Free Radicals.Oxid Med Cell Longev,2015:1-7.

[0209]

[22] Mahns A,Wolber R, F,et al(2004)Contribution of UVB and UVA toUV-dependent stimulation of cyclooxygenase-2expression in artificialepidermis.Photochem Photobio S 3:257-262.

[0210]

[23] Tripp C.S,Blomme E.A.G,Chinn K.S,et al(2003)Epidermal COX-2Induction Following Ultraviolet I rradiation:Suggested Mechanism for the Roleof COX-2 Inhibition in Photoprotection.J invest Dermatol,121(4):853-61.

[0211]

[24] Adamska K,Pawlaczyk M,Bowszyc-Dmochowska M,et al(2017)Cyclooxygenase-2 expression in actinic keratosis.Adv Dermatol Allergol 2018:XXXV(6):626-630.

[0212]

[25] Zaiss AK,Zuber J,Chu C,et al(2014)Reversible Suppression ofCyclooxygenase 2(COX-2)Expression In Vivo by Inducible RNA Interference.PLoSOne 9(7):e101263.

Claims

1. A non-therapeutic method for preventing, alleviating or treating PTGS2-induced human skin disorders and related functional disorders, comprising or consisting of the following steps: - Applying an effective amount of a carnosine compound according to formula (I) to human skin Wherein R1 represents H or CH3, and R2 represents H or COOH.

2. The method of claim 1, wherein the skin disorder is inflammation, aging and / or skin cancer.

3. The method according to claim 1, wherein the functional disorder is fever and / or pain.

4. The method according to claim 1, wherein the carnosine compound is selected from the group consisting of carnosine, L-carnosine, D-carnosine, D / L-carnosine, anserine, D-anserine, L-anserine, L-anserine*HNO3 and mixtures thereof.

5. The method of claim 1, wherein the carnosine compound is L-carnosine.

6. The method of claim 1, wherein the carnosine compound is applied to human skin as an ingredient of a cosmetic skin or sunscreen formulation.

7. The method according to claim 6, wherein the cosmetic preparation is a cream, lotion, ointment or spray.

8. The method according to claim 6, wherein the content of the carnosine compound in the cosmetic preparation is from about 0.01 wt% to about 5 wt% - based on the preparation.

9. The method according to claim 6, wherein the cosmetic preparation further comprises at least one primary and / or secondary sun protection factor.

10. The carnosine compound according to formula (I) is used as a medicament for preventing, alleviating and / or treating human skin disorders or related functional disorders induced by enhanced expression of PTGS2.

11. The compound for use according to claim 10, wherein the compound is L-carnosine.

12. The compound for use according to claim 1, wherein the skin disorder is selected from inflammation, aging and / or skin cancer.

13. The compound for use according to claim 1, wherein the associated dysfunction is selected from fever and / or pain.

14. The compound for use according to claim 1, wherein the carnosine is formulated as a cream, lotion, ointment or spray.

15. Carnosine compounds according to formula (I) Where R1 represents H or CH3, R2 represents H or COOH As a drug, it is used to prevent, alleviate or treat human skin disorders and related functional disorders induced by PTGS2.

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