Traditional Chinese medicine composition for treating alcoholic liver disease and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating alcoholic liver diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3-7 parts of cordyceps militaris, 10-30 parts of radix puerariae, 10-30 parts of hovenia dulcis thunb, 4-10 parts of radix paeoniae alba, 3-7 parts of lucid ganoderma and 4-10 parts of emblic leafflower fruit. The traditional Chinese medicine composition disclosed by the invention has good activity for treating alcoholic liver diseases, is comprehensive in medicine effect and easy to absorb, can achieve the effects of diminishing inflammation and relieving pain while dispelling the effects of alcohol, protecting the liver and conditioning five internal organs, and can quickly improve the illness state of a patient. The preparation method of the traditional Chinese medicine composition is simple, raw materials are easy to obtain and basically non-toxic, and the traditional Chinese medicine composition is suitable for popular use and has good application prospects.

Description

Technical Field

[0001] The invention belongs to the field of Chinese medicine preparations, and in particular relates to a Chinese medicine composition for treating alcoholic liver disease and a preparation method thereof. Background Art

[0002] Alcoholic liver disease is a liver disease caused by long-term heavy drinking. It usually presents as fatty liver in the early stage, and can then develop into alcoholic hepatitis, liver fibrosis and cirrhosis. The main clinical features of alcoholic liver disease are nausea, vomiting, jaundice, liver enlargement and tenderness, etc. The clinical classification of alcoholic liver disease is: mild alcoholic liver disease, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, alcoholic cirrhosis. Alcoholic liver disease is one of the common liver diseases in my country and seriously endangers people's health. Traditional Chinese medicine has the advantages of treating both the symptoms and the root cause of alcoholic liver disease, few toxic and side effects, and low cost. Finding a traditional Chinese medicine formula suitable for the treatment of alcoholic liver disease in the modern population is an urgent problem to be solved. Summary of the invention

[0003] In view of the above technical problems, the present invention provides a Chinese medicine composition capable of effectively treating alcoholic liver disease and a preparation method thereof.

[0004] In order to achieve the above object, the technical solution adopted by the present invention is:

[0005] A Chinese medicine composition for treating alcoholic liver disease, characterized in that it is made from the following raw materials in parts by weight:

[0006] 3-7 parts of Cordyceps militaris;

[0007] 10-30 parts of Pueraria root;

[0008] Hovenia dulcis 10-30 parts;

[0009] 4-10 parts of white peony root;

[0010] 3-7 portions of Ganoderma Lucidum;

[0011] 4-10 servings of Phyllanthus emblica.

[0012] Preferably, it is made from the following raw materials in parts by weight:

[0013] 4-6 parts of Cordyceps militaris;

[0014] 15-24 parts of Pueraria root;

[0015] Hovenia dulcis 14-26 parts;

[0016] 6-8 parts of white peony root;

[0017] 4-7 portions of Ganoderma Lucidum;

[0018] 6-9 portions of Phyllanthus emblica.

[0019] Preferably, it is made from the following raw materials in parts by weight:

[0020] 6 parts of Cordyceps militaris;

[0021] 20 parts of Pueraria root;

[0022] Hovenia dulcis 24 parts;

[0023] 8 parts white peony root;

[0024] 6 portions of Lingzhi;

[0025] 7 parts of Phyllanthus emblica.

[0026] Preferably, the Ganoderma lucidum is purple Ganoderma lucidum, red Ganoderma lucidum or mulberry lindera Ganoderma lucidum.

[0027] Preferably, the Cordyceps militaris is a Cordyceps militaris fruiting body.

[0028] According to the historical records of traditional Chinese medicine, the above-mentioned Chinese medicinal materials have the following pharmacological activities and functional indications:

[0029] The fruiting body of Cordyceps militaris is flat in nature and sweet in taste. It enters the lung and kidney meridians. Its main active ingredients are cordycepin, cordyceps polysaccharide, cordycepic acid, etc. It has the effects of protecting the lungs and kidneys, anti-oxidation, stopping bleeding and resolving phlegm, retaining essence and replenishing qi. In addition, Cordyceps militaris can prevent liver fibrosis and benefit the lungs.

[0030] Pueraria root is sweet, pungent and cool in nature and enters the spleen and stomach meridians. It has the effects of detoxifying alcohol, invigorating the spleen and stomach, and quenching thirst. Pueraria root contains isoflavones such as puerarin, daidzein, and daidzein, which can inhibit alcohol intake, reduce alcohol concentration, regulate alcohol metabolism, and reduce damage to the liver, the most important organ for alcohol metabolism. At the same time, Pueraria root has a certain effect on hypertension, hyperlipidemia, hyperglycemia, and cardiovascular and cerebrovascular diseases.

[0031] Hovenia dulcis is mild in nature and sweet in taste. It enters the lung and spleen meridians, relieves alcohol and stops vomiting, dispels wind and dredges the meridians, eliminates dampness and heat, and promotes bowel movements. The chemical components of Hovenia dulcis include flavonoids, saponins, glycosides, alkaloids, and fatty acids. Its pharmacological effects include the effects of relieving alcohol, protecting liver cells, and anti-mutation and anti-tumor.

[0032] White peony root tastes bitter and sour, is slightly cold in nature, and enters the liver and spleen meridians. It has the effects of nourishing blood and regulating menstruation, restraining yin and stopping sweating, softening the liver and relieving pain, and calming liver yang. The main active ingredients include paeoniflorin, paeoniflorin, benzoic acid, etc., which have significant anti-inflammatory and antioxidant effects and can reduce pain and swelling caused by inflammation. Benzoic acid has certain antibacterial and antioxidant effects, which helps protect cells from oxidative damage.

[0033] Lingzhi is sweet and mild in nature, and enters the heart, lung, liver, and kidney meridians. It has the effects of replenishing qi and blood, nourishing the heart and calming the mind. The main active ingredients are amino acids, peptides, proteins, fungal lysozyme, as well as sugars and triterpenes. It has the effects of protecting the liver and detoxifying, enhancing the functions of the heart and lungs, increasing blood oxygen, regulating the functions of the five internal organs, and strengthening the body.

[0034] Phyllanthus emblica is sweet and sour, cool in nature, and enters the lung and stomach meridians. It has the effects of clearing heat and cooling blood, promoting digestion and strengthening the stomach, promoting body fluid and relieving cough. Phyllanthus emblica is a plant with both medicinal and edible properties. Its fruit is rich in 17 kinds of amino acids required by the human body and active substances such as gallic acid, vitamins, and flavonoids. It has anti-tumor, anti-aging, diabetes treatment, antibacterial and anti-inflammatory effects.

[0035] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition for treating alcoholic liver disease, comprising the following steps:

[0036] (1) Select and remove impurities from the raw materials, and weigh each raw material according to its weight;

[0037] (2) Soak the API in hot water 9-12 times the weight of the API for 3 hours at a temperature of 70-80°C; decoct for 20-30 minutes, decoct twice, filter, and obtain a filtrate and a residue;

[0038] (3) combining the two decoctions, filtering and concentrating the filtrate under reduced pressure at 0.08 MPa and 65° C. until the relative density of the liquid is 1.02-1.32;

[0039] (4) Sterilize and package to obtain a decoction.

[0040] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition for treating alcoholic liver disease, comprising the following steps:

[0041] (1) Weigh each raw material drug according to weight, store each drug separately and process it according to the following steps: dry it in an oven at 60°C, grind it coarsely, pass it through a 30-100 mesh sieve, and grind it in a nano ball mill for 10-12 hours to obtain nano powder with a particle size of 200-500 nm, which is set aside;

[0042] (2) placing the various types of Chinese medicine nanopowders obtained in step (1) in a mixer and stirring for 10-20 minutes to obtain a nanopowder Chinese medicine composition with uniform components;

[0043] (3) The nano-powder Chinese medicine composition obtained in step (2) is filled into capsules by a capsule filling machine, and the capsules are bottled or packaged on a press plate to obtain a finished product.

[0044] Compared with the prior art, the advantages and positive effects of the present invention are:

[0045] The Chinese medicine composition of the present invention has good activity in treating alcoholic liver disease, has comprehensive drug effects, is easily absorbed, and can achieve anti-inflammatory and analgesic effects while sobering up, protecting the liver, and regulating the five internal organs, and can quickly improve the patient's condition; and the preparation method of the Chinese medicine composition of the present invention is simple, the raw materials are easily available and are basically non-toxic, and the Chinese medicine composition is suitable for popular use, and has good application prospects. DETAILED DESCRIPTION

[0046] In order to better understand the present invention, the following is a detailed description with reference to the embodiments.

[0047] Embodiment 1:

[0048] Prescription: 6 parts of Cordyceps militaris, 20 parts of Pueraria root, 24 parts of Hovenia dulcis, 8 parts of White Peony Root, 6 parts of Phellinus igniarius, and 7 parts of Phyllanthus emblica.

[0049] Preparation method:

[0050] (1) Select and remove impurities from the raw materials, and weigh each raw material according to its weight;

[0051] (2) Soak the API in hot water 11 times the weight of the API for 3 hours at a temperature of 70-80°C; decoct for 20 minutes, decoct twice, and filter to obtain a filtrate and a filter residue;

[0052] (3) combining the two decoctions, filtering and concentrating the filtrate under reduced pressure at 0.08 MPa and 65° C. until the relative density of the liquid is 1.02-1.32;

[0053] (4) Sterilize and package to obtain a decoction.

[0054] Embodiment 2:

[0055] Prescription: 5 parts of Cordyceps militaris, 21 parts of Pueraria root, 18 parts of Hovenia dulcis, 8 parts of White Peony Root, 6 parts of Ganoderma lucidum, and 8 parts of Phyllanthus emblica.

[0056] Preparation method:

[0057] (1) Weigh each raw material drug according to weight, store each drug separately and process it according to the following steps: dry it in an oven at 60°C, grind it coarsely, pass it through a 50-mesh sieve, and grind it in a nano ball mill for 10 hours to obtain nano powder with a particle size of 200 to 500 nm, which is set aside;

[0058] (2) placing the various types of Chinese medicine nanopowders obtained in step (1) in a mixer and stirring for 15 minutes to obtain a nanopowder Chinese medicine composition with uniform components;

[0059] (3) The nano-powder Chinese medicine composition obtained in step (2) is filled into capsules by a capsule filling machine, and the capsules are bottled or packaged on a press plate to obtain a finished product.

[0060] The above description is only a preferred embodiment of the present invention and does not limit the present invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes and apply it to other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for treating alcoholic liver disease, characterized in that: Made from the following raw materials in parts by weight: 3-7 parts of Cordyceps militaris; 10-30 parts of Pueraria root; Hovenia dulcis 10-30 parts; 4-10 parts of white peony root; 3-7 portions of Ganoderma Lucidum; 4-10 servings of Phyllanthus emblica.

2. The Chinese medicine composition for treating alcoholic liver disease according to claim 1, characterized in that: Made from the following raw materials in parts by weight: 4-6 parts of Cordyceps militaris; 15-24 parts of Pueraria root; Hovenia dulcis 14-26 parts; 6-8 parts of white peony root; 4-7 portions of Ganoderma Lucidum; 6-9 portions of Phyllanthus emblica.

3. The Chinese medicine composition for treating alcoholic liver disease according to claim 1, characterized in that: Made from the following raw materials in parts by weight: 6 parts of Cordyceps militaris; 20 parts of Pueraria root; Hovenia dulcis 24 parts; 8 parts white peony root; 6 portions of Lingzhi; 7 parts of Phyllanthus emblica.

4. The Chinese medicine composition for treating alcoholic liver disease according to claim 1, characterized in that: The ganoderma lucidum is purple ganoderma lucidum, red ganoderma lucidum or mulberry tinctoria ganoderma.

5. The Chinese medicine composition for treating alcoholic liver disease according to claim 1, characterized in that: The Cordyceps militaris is the fruiting body of Cordyceps militaris.

6. A method for preparing the Chinese medicine composition for treating alcoholic liver disease according to any one of claims 1 to 5, characterized in that: The method comprises the following steps: (1) selecting and removing impurities from raw materials, and weighing each raw material according to weight; (2) soaking the raw materials in hot water of 9-12 times the weight of the raw materials for 3 hours at a water temperature of 70-80°C; decocting for 20-30 minutes, decocting twice, filtering, and obtaining a filtrate and a filter residue; (3) combining the two decoctions, filtering, and concentrating the filtrate under reduced pressure at 0.08MPa and 65°C until the relative density of the liquid is 1.02-1.32; (4) sterilizing and packaging to obtain a decoction.

7. A method for preparing the Chinese medicine composition for treating alcoholic liver disease according to any one of claims 1 to 5, characterized in that: The method comprises the following steps: (1) weighing each raw material drug according to the weight portion, storing each drug independently and processing according to the following steps: drying in an oven at 60°C and then coarsely crushing, passing through a 30-100 mesh sieve, and then crushing in a nano ball mill for 10-12 hours to obtain nano powder with a particle size of 200-500 nm for standby use; (2) placing various types of traditional Chinese medicine nano powders obtained in step (1) in a mixer, stirring for 10-20 minutes, and obtaining a nano powder traditional Chinese medicine composition with uniform components; (3) filling the nano powder traditional Chinese medicine composition obtained in step (2) into capsules through a capsule filling machine, and the capsules are bottled or packaged on a press plate to obtain a finished product.