Multi-channel extraction drawer

Abstract

An automated analyzer may include a drawer assembly. The drawer assembly may include a two-channel drawer including a pipette tip station configured to receive two pipette tip holders, an extraction container station configured to receive two extraction container holders, and an amplification plate station configured to receive two amplification plates. The drawer assembly may include an extractor module positioned relative to the extraction container station, where the extractor module includes a magnet configured to apply a magnetic field to an extraction container holder of the two extraction container holders.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 422,700, filed on November 4, 2022, the entire contents of which are incorporated herein by reference. Technical Field

[0003] The technology described herein generally relates to automated diagnostic analyzers including components thereof. In some aspects, the technology more specifically relates to a multi-channel extraction drawer. Background Art

[0004] Diagnostic testing of biological samples helps the healthcare industry diagnose and treat diseases quickly and effectively. Clinical laboratories that perform such diagnostic testing already receive hundreds or thousands of samples per day, and the demand continues to increase. Automation of sample analysis helps with the challenge of managing such a large number of samples. Automated sample analysis is typically performed by automated analyzers, which are usually self-contained systems that perform multi-step processing on biological samples to obtain diagnostic results.

[0005] Several current automated clinical analyzers provide the user with a series of automated tests or assays that can be performed on a provided sample. Furthermore, when the samples arrive at the laboratory, they are often not ready for analysis. In order to prepare samples for testing with an automated analyzer, laboratory technicians typically transfer aliquots of the samples from primary containers received by the laboratory into secondary containers that can be used for analysis by the analyzer. Furthermore, the technician typically must know which tests are to be performed on the sample so that the technician can select a specific test reagent or diluent to pair with the sample. This can be time consuming and can result in operator error and the risk of contracting an infectious disease.

[0006] Pre-analytical systems have also emerged that are designed to help prepare samples for analysis and further free operators from the workflow between receiving the sample in the laboratory and the test results of the analyzer. However, many of these systems still require extensive technician involvement, such as: before the sample is loaded into the pre-analytical system; after the sample is prepared by the pre-analytical system; and after the analyzer completes the analysis.

[0007] For example, some pre-analytical systems can automatically transfer aliquots of a sample from a first container to a second container. However, such systems typically require a technician to manually match the identification codes of the first and second containers before loading them into the system, which can be time-consuming and prone to errors.

[0008] Additionally, many of these systems cannot be integrated with one or more analyzers, and conversely, the analyzers cannot be integrated with these systems. In this regard, a technician must be present to manually transfer the sample from the pre-analytical system to the analyzer and from the analyzer to a storage location once the analysis is complete. This requires a skilled labor force to perform menial tasks and can be distracting because the technician must always be aware of the sample's progress through the pre-analytical system and analyzer so that the technician is ready to transfer the sample when it is ready to minimize downtime.

[0009] In addition, current pre-analytical systems typically prepare samples at a different rate than the analyzer evaluates these samples. This makes the integration between the pre-analytical system and the analyzer more complex. In this regard, a technician may be required to continuously track samples prepared by the pre-analytical system until a full batch of samples has been accumulated for manual transfer to the analyzer. Alternatively, a technician may transfer a partial batch to the analyzer, which reduces the productivity of the analyzer.

[0010] Therefore, while current automated pre-analytical systems and analyzers benefit clinical laboratories, there is still room for better integration and automation of various systems. Summary of the invention

[0011] The present disclosure describes devices, systems, and methods for sample processing and analysis.

[0012] In some embodiments, a dual channel drawer assembly is provided. The dual channel drawer assembly may include a dual channel drawer. The dual channel drawer may include a pipette tip station configured to accommodate two pipette tip holders. The dual channel drawer may include an extraction container station configured to accommodate two extraction container holders. The dual channel drawer may include an amplification plate station configured to accommodate two amplification plates. The dual channel drawer assembly may include an extractor module positioned relative to the extraction container station. In some embodiments, the extractor module includes a magnet configured to apply a magnetic field to an extraction container holder in the two extraction container holders.

[0013] In some embodiments, the extractor module is configured to process samples from two extraction container holders simultaneously. In some embodiments, the extractor module is configured to move up and down relative to the two extraction container holders. In some embodiments, the extractor module is configured to move up and down along one or more guide rails. In some embodiments, the dual channel drawer includes a retention feature that is configured to extend above a portion of the pipette tip station and the extraction container station. In some embodiments, the dual channel drawer includes a latch mechanism that includes a push-to-close latch. In some embodiments, the dual channel drawer includes an ejection mechanism that is configured to facilitate the sliding extension of the dual channel drawer. In some embodiments, the dual channel drawer includes a telescopic slide. In some embodiments, the dual channel drawer assembly includes two pipette tip holders, two extraction container holders, and two amplification plates. In some embodiments, the dual channel drawer assembly includes three of the dual channel drawers. In some embodiments, the dual channel drawer assembly includes a tip drawer that is configured to accommodate five pipette tip holders.

[0014] In some embodiments, a dual channel drawer assembly is provided. The dual channel drawer assembly may include a dual channel drawer. The dual channel drawer may include a pipette tip station configured to accommodate two pipette tip holders. The dual channel drawer may include an extraction container station configured to accommodate two extraction container holders. The dual channel drawer may include an amplification plate station configured to accommodate two amplification plates. The dual channel drawer assembly may include an extractor module positioned relative to the extraction container station. In some embodiments, the extractor module includes a magnet configured to apply a magnetic field to an extraction container holder in the two extraction container holders.

[0015] In some embodiments, the extractor module is configured to process samples from an extraction container holder. In some embodiments, the extractor module is configured to move up and down relative to two extraction container holders. In some embodiments, the extractor module is configured to move up and down along one or more guide rails. In some embodiments, the dual channel drawer includes a retention feature that is configured to extend above a portion of the pipette tip station and the extraction container station. In some embodiments, the dual channel drawer includes a latch mechanism that includes a push-to-close latch. In some embodiments, the dual channel drawer includes an ejection mechanism that is configured to facilitate the sliding extension of the dual channel drawer. In some embodiments, the dual channel drawer includes a telescopic slide. In some embodiments, the dual channel drawer assembly may include two pipette tip holders, two extraction container holders, and two amplification plates. In some embodiments, the dual channel drawer assembly may include three of the dual channel drawers. In some embodiments, the dual channel drawer assembly may include a tip drawer configured to accommodate five pipette tip holders. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a front perspective view of a high-throughput diagnostic system according to one embodiment of the present disclosure.

[0017] Figure 2 There is no shell Figure 1 Front perspective view of an analyzer of a high-throughput diagnostic system.

[0018] Figure 3 yes Figure 2 Another front perspective view of the analyzer.

[0019] Figures 4A-4F yes Figure 1 A view of the analyzer processing platform and its components of a high-throughput diagnostic system.

[0020] Figures 5A-5C is a view of one embodiment of a dual channel drawer and extractor according to the present disclosure.

[0021] Figures 6A-6C yes Figure 5A A view of a dual channel drawer relative to an analyzer according to the present disclosure.

[0022] Figure 7 is a view of one embodiment of a dual channel drawer according to the present disclosure.

[0023] Figure 8 is a view of one embodiment of a three-channel drawer according to the present disclosure.

[0024] Figures 9A-9B is a view of one embodiment of a six channel drawer and a fixed retaining housing according to the present disclosure.

[0025] Figures 10A-10C is a view of an extractor scissor lift according to the present disclosure.

[0026] Fig.11 is a view of an extractor thruster according to the present disclosure. DETAILED DESCRIPTION

[0027] Embodiments of the present disclosure provide devices, systems and methods capable of processing samples. In some embodiments, a multichannel drawer is provided, which accommodates consumables used in the process, such as two or more pipette tip holders, two or more extraction container holders and two or more amplification plates. One embodiment includes one or more extractor modules, which are configured to apply a magnetic field to the extraction container in the multichannel drawer. In some embodiments, a plate sealer is provided, which seals the amplification plate for processing. As described herein, the multichannel drawer and the plate sealer can be components of a high-throughput system, which is configured to process multiple samples while reducing the participation of technicians. The system described herein can prepare samples for analysis while automating one or more steps from receiving the sample to generating a test result.

[0028] Figure 1 A high-throughput system 00 according to one embodiment of the present disclosure is depicted. The high-throughput system 00 may include a first analyzer 2000. The high-throughput system 00 may include a second analyzer 4000. The high-throughput system 00 may include any number of analyzers. The high-throughput system 00 may include a pre-analysis system 10. The analyzers 2000, 4000, and the pre-analysis system 10 are modular so that they can be physically connected and disconnected from each other. The analyzers 2000, 4000, and the pre-analysis system 10 are modular so that they can be electronically connected and disconnected from each other. In some embodiments, the analyzers 2000, 4000 may have the same construction. The analyzers 2000, 4000 may have the same functions. The analyzers 2000, 4000 may be copies of each other. The pre-analysis system 10 may be connected to at least two identical analyzers. In some embodiments, the analyzers 2000, 4000 may have different constructions. The analyzers 2000, 4000 may have different functions. Analyzers 2000, 4000 can perform different operations. Analyzers 2000, 4000 can analyze different determinations. Pre-analysis system 10 can be connected to at least two different analyzers. The modularity of pre-analysis system 10 allows it to be connected to any analyzer constructed in this way. As shown in the figure, the first and second analyzers 2000, 4000 are arranged on opposite sides of pre-analysis system 10 in a linear arrangement. In other embodiments, pre-analysis system 10 can be arranged at one end of high-throughput system 00. Pre-analysis system 10 and analyzers 2000, 4000 can be arranged in any physical arrangement. Analyzer 4000 can be connected to either side of pre-analysis system 10.

[0029] The pre-analysis system 10 may include a sample container shuttle transport component 4250, such as Figure 4AThe sample container shuttle transport assembly 4250 can transfer the sample container to one or more analyzers 2000, 4000. When the analyzer 4000 is located on the left side of the system 10 (on the left side of the system 10), the sample container shuttle transport assembly 4250 can transfer the sample container to one or more analyzers 2000, 4000. Figure 1 4000). In other embodiments, the sample container shuttle assembly 4250 of the pre-analysis system 10 can extend toward the analyzer 4000 when the analyzer 4000 is located on the right side of the system 10. In some embodiments, the sample container shuttle assembly 4250 terminates at the threshold of the analyzer 2000, 4000. In other embodiments, the sample container shuttle assembly 4250 extends into the analyzer 2000, 4000. The analyzer 2000, 4000 can have a conveyor that can continue the path of each shuttle assembly 4250 into the analyzer 2000, 4000. The sample container shuttle assembly 4250 can be a rack or carrier structure with a plurality of receptacles, each receptacle being sized and configured to receive a sample container. The sample container shuttle transport assembly 4250 may include an actuator that causes movement of a rack or carrier structure. The high-throughput system 00 may include an opening 120 to receive a rack or carrier structure with multiple sample containers. The analyzer 2000, 4000 may include one or more submodules 2110, 2120, 2130. These submodules may be the same or different from each other.

[0030] The high-throughput system 00 may include an overall system display interface 1332. Data may be input and viewed through a graphical user interface ("GUI") that may be displayed on the display interface 1332. Data may be input and viewed through a graphical user interface specifically associated with the analyzer 2000, 4000. Data may also be input from the visual system of the multi-purpose robot. Data may also be input from a scanner within the pre-analysis system 10. Data may also be obtained by sensors (such as door sensors) to obtain information about certain conditions and activities occurring within the analyzer 2000, 4000. Data may also be obtained by sensors (such as temperature sensors) to obtain information about certain conditions and activities occurring within the analyzer 2000, 4000. Data regarding the location of one or more consumables may also be obtained. Data regarding the location of the sample container may also be obtained.

[0031] The pre-analysis system 10 can be an automated system for pre-analysis processing of samples to be determined. The analyzers 2000 and 4000 can be modular systems configured to operate in coordination with the pre-analysis system 10. The analyzers 2000 and 4000 can be configured to be modularly connected to the pre-analysis system 10. The analyzers 2000 and 4000 can be configured for high-throughput processing and analysis of samples. The analyzer 4000 will be described in more detail below. The analyzer 2000 can include any of the features described herein.

[0032] Figure 2 and Figure 3 Analyzer 4000 is shown. Analyzer 4000 may include a structural frame 4011 composed of several support components. For example, the support components may be segments of metal pipe. Frame 4011 is constructed to support and define various platforms or levels for sample processing and analysis. The platforms may include auxiliary platforms 4012. The platforms may include processing platforms 4014. The platforms may include multi-purpose robotic platforms 4016. Analyzer 4000 may include a housing or casing surrounding frame 4011. The casing may include a housing such as Figure 1 As shown. Analyzer 4000 may include two detectors 4260a, 4260b. Detectors 4260a, 4260b may be located at opposite ends of analyzer 4000. Detectors 4260a, 4260b may have cavities facing the center of analyzer 4000. Figure 4F As shown, detectors 4260a, 4260b may have a housing for receiving a sealed amplification plate 4040. Detectors 4260a, 4260b may have a thermal cycler for amplifying the target analyte in the sealed amplification plate 4040. Detectors 4260a, 4260b may use a set of illuminators (e.g., LED lights) to detect the target analyte. Analyzer 4000 may include a plate sealer 4220. Plate sealer 4220 may seal amplification plate 4040. Analyzer 4000 may include waste 4004 to process amplification plate 404. Analyzer 4000 may include a liquid waste storage for receiving all liquid wastes of analyzer 4000. Analyzer may include a multi-purpose robot 4300.

[0033] Figure 4A and 4BA processing platform 4014 is depicted. Detectors 4260a, 4260b are shown as being associated with the processing platform 4014. A sample container shuttle transport assembly 4250 is also shown, which can transport sample containers to the analyzer 4000. The processing platform 4014 can include one or more consumable drawers 4120. In the illustrated embodiment, six consumable drawers 4120 are shown. The processing platform 4014 can include any number of drawers, including one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, or any range of two of the foregoing values. Each drawer 4120 includes a single channel of consumables. Each drawer 4120 can hold a pipette tip holder 4060. Each drawer 4120 can hold an extraction container 4020. Each drawer 4120 can hold an amplification plate 4040. In the illustrated embodiment, the processing platform 4014 includes six consumable drawer assemblies 4120. Each drawer 4120 can hold most of the consumables used in the assay workflow.

[0034] The processing platform 4014 may include a plate sealer 4220. The plate sealer 4220 may have a movable platform 4224 that receives the amplification plate 4040 and moves the amplification plate 4040 into the plate sealer 4220. The processing platform 4014 may include one or more orbital shakers 4230. The orbital shaker 4230 may swing one or more sealed amplification plates 4040 in a circular motion so that the dried reagents and the eluted samples in the compartment of the sealed amplification plate 4040 are fully rehydrated. The processing platform 4014 may include a reagent tank assembly 4050. The reagent tank assembly 4050 may include a groove that holds a large amount of reagents. The processing platform 4014 may include one or more perforators 4240. The perforator 4240 may be formed as a heavy seal that punctures the reagent tank assembly 4050. The piercing tools 4240 are seated in respective nests or carriers 4270, 4280 toward the center rear of the processing platform 4014 until they are used to pierce the reagent tank assembly 4050. The processing platform 4014 may include one or more waste chutes 4210. The waste chutes 4210 may extend through the processing platform 4014. The waste chutes 4210 may receive the spent amplification plates 4040. The processing platform 4014 may include a tip drawer 4110. The tip drawer 4110 may accommodate one or more pipette tip holders 4060. In the illustrated embodiment, the tip drawer 4110 may hold five pipette tip holders 4060.

[0035] Figure 4CA side perspective view of a drawer 4120 is depicted. The drawer 4120 may include a housing 4122. The drawer 4120 may include a pipette tip station 4124. The drawer 4120 may include an extraction container station 4126. The drawer 4120 may include an amplification plate station 4128. The stations 4124, 4126, 4128 may be arranged linearly. The pipette tip station 4124 may be near the front of the drawer 4120. The extraction container station 4126 may be between the pipette tip station 4124 and the amplification plate station 4128. The amplification plate station 4128 may be near the rear of the drawer 4120. The drawer 4120 may include other arrangements of the pipette tip station 4124, the extraction container station 4126, and the amplification plate station 4128. The pipette tip station 4124 may be configured to hold a pipette tip holder 4060. The extraction container station 4126 may be configured to hold an extraction container holder 4020. The amplification plate station 4128 can be configured to hold an amplification plate 4040. The drawer 4120 can be considered a single channel drawer. The drawer 4120 can hold a single pipette tip holder 4060. The drawer 4120 can hold a single extraction container holder 4020. The drawer 4120 can hold a single amplification plate 4040.

[0036] Drawer 4120 can be configured to include an extractor module 4125. The extractor module 4125 can be disposed within a housing 4122 of the drawer 4120. The extractor module 4125 can include one or more magnets. The magnets can be mounted to a plate or platform of the extractor module 4125. The magnets can be mounted in horizontal rows. The magnets can be disposed on either side of the extraction container within the extraction container holder 4020. The extractor module 4125 can provide a movable magnetic field for extracting polynucleotides, such as DNA, from a sample. The extractor module 4125 can be housed in the consumables drawer 4120 below the extractor container station 4126. The extractor module 4125 can be selectively moved in an up and down direction along one or more guide rails 4127. The guide rails 4127 can be disposed on one or more side walls that separate compartments below each of the stations 4124, 4126, and 4128. The extractor module 4125 is disposed in Figure 4C The extractor module 4125 can be in an upward or extraction position. The extractor module 4125 can be lowered by moving along the guide rail 4127.

[0037] The drawer 4120 may include a hinged retaining feature 4121. The retaining feature 4121 may rotate about a hinge 4123. The retaining feature 4121 may be a spring loaded arm. The retaining feature 4121 may be hingedly connected to the housing 4122. The retaining feature 4121 may be connected directly behind the extraction container station 4126. The retaining feature 4121 may have a retaining position and a consumable replacement position. In the retaining position, as shown in FIG. Figure 4CAs shown, the retaining feature 4121 extends over the pipette tip station 4124 and the extraction container station 4126. The retaining feature 4121 may include an opening that allows access to a pipette within the pipette tip holder 4060. The retaining feature 4121 may include an opening that allows access to an extraction container within the extraction container holder 4020. In this position, the retaining feature 4121 is configured to contain the perimeter of the pipette tip holder 4060 located in the pipette tip station 4124. In this position, the retaining feature 4121 is configured to contain the perimeter of the extraction container holder 4020 located in the extraction container station 4126. The retaining feature 4121 contains a perimeter that allows access thereto via the opening in the retaining feature 4121. The retaining feature 4121 secures the edge of the pipette tip holder 4060. The retaining feature 4121 secures the edge of the extraction container holder 4020. The retaining feature 4121 limits or prevents the extraction container holder 4020 and the pipette tip holder 4060 from being accidentally moved during operation. The retaining feature 4121 limits or prevents detachment during the pipetting operation. When the consumables in the drawer 4120 need to be replaced, the drawer 4120 can be extended from the front of the analyzer 4000. In some embodiments, when the drawer 4120 is extended, the feature configured to lock the retaining feature 4121 in the retaining position is released. Under the bias of the torsion spring located in the hinge 4123, the retaining feature 4121 rotates around the hinge 4123 to the consumable replacement position, which provides the user with a gap to replenish consumables in the drawer 4120.

[0038] Return to reference Figure 4A , drawer 4120 is seated at the front of analyzer 4000. Drawer 4120 can be disposed between detectors 4260a, 4260b. Drawer 4120 can include a visual indicator, such as a colored LED, at its front end that indicates the status of drawer 4120 to the user. The visual indicator can let the user know that drawer 4120 is currently being used. The visual indicator can let the user know that drawer 4120 is ready for use. The visual indicator can let the user know that drawer 4120 needs to be refilled with consumables.

[0039] Figure 4D-4EAn extraction container holder 4020 is shown. The extraction container holder 4020 can be a multi-layer structure. The extraction container holder 4020 can include a lower portion 4025 with a plurality of openings 4029. The lower portion 4025 can include one or more features 4028. The features 4028 on the sidewall 4027 of the lower portion 4025 can provide an interference fit with the features on the drawer 4120 of the analyzer 4000. The extraction container holder 4020 can include a plurality of extraction containers 4026. The extraction container 4026 can be connected via one or more foil strips 4023. Before adding the sample, the foil strip 4023 can be penetrated with a pipette tip. Each extraction container 4026 can contain iron oxide ("FOX") particles to extract polynucleotides, such as DNA, from the sample. The extraction container holder 4020 can include an upper portion 4022 with a plurality of openings 4021. The strips 4023 can be aligned within the openings 4021. The upper portion 4022 may include one or more ribs 4024. The ribs 4024 may extend in a direction transverse to the foil strip 4023 of the extraction container 4026. The ribs 4024 may provide structural rigidity for the extraction container holder 4020. The lower portion 4025 allows the extraction container 4026 to partially extend through it. The extraction container 4026 extends through the extraction container holder 4020 to allow the extractor module 4125 to process. A barcode may be located on the upper portion 4022, which helps to track information such as batch, expiration date, and serial number of the contents of the extraction container 4026. The extraction container holder 4020 may be assembled with enough extraction containers 4026 to perform a single run. In the depicted embodiment, the extraction container holder 4020 may accommodate 32 extraction containers 4026. The extraction containers 4026 may be arranged along four foil strips 4023. The extraction containers 4026 may be arranged in a grid.

[0040] The pipette tips are disposed in a pipette tip holder 4060. The pipette tip holder 4060 can be configured to accommodate 96 pipette tips. The pipette tips can be arranged in a grid. In some embodiments of the analyzer 4000, four 1000 μL tips are used to process each sample. In addition, one reagent pipette tip can be used for each batch of samples. This helps to reduce the number of tips used because the reagent pipette tip is not in direct contact with the sample.

[0041] Figure 4FAmplification plate 4040 is shown. Amplification plate 4040 may include a plate body 4041. Plate body 4041 may include one or more engagement openings 4044a, 4044b extending into respective sides 4042a, 4042b of body 4041. Engagement openings 4044a, 4044b may allow a fixture of a multipurpose robot 4300 to engage amplification plate assembly 4040 from opposite sides of amplification plate assembly 4040. For example, opening 4044a extends through side 4042a and the side directly opposite to side 4042a. In addition, opening 4044b extends through side 4042b and through the side directly opposite to the side of side 4042b. These openings allow multipurpose robot 4300 to grip and lift amplification plate 4040 when amplification plate 4040 is in different orientations. Plate body 4041 may include a plurality of wells defining amplification compartments 4045. Dried reagents for amplifying a target may be provided to compartment 4054. Amplification plate 4040 may have visual identification of the reagents contained in compartment 4045 of amplification plate 4045, such as color coding.

[0042] As each drawer 4120 is extended from the analyzer 4000, the user removes and replaces the used amplification container holder 4020 and the empty tip holder 4060. The user also adds the unused amplification plate 4040 to the drawer 4120. Once the drawer 4120 is reinserted, the instrument 00 can inventory that particular drawer 4120 to check for loading errors. The instrument 00 can be updated to indicate that the drawer 4120 is ready for extraction.

[0043] Return to reference Figure 4A , the processing platform 4014 also includes a tip drawer 4110. The tip drawer 4110 can be configured to hold one or more pipette tip holders 4060. The tip drawer 4110 can accommodate five pipette tip holders 4060. Each pipette tip holder 4060 can be a 96-well tip carrier. The tip drawer 4110 can be constructed similarly to the drawer 4120 in that it includes a visual indicator at its front end. The pipette tip holders 4060 in the tip drawer 4110 can provide pipette tips for each sample extraction performed in the consumables drawer 4120, as well as reagent tips and any excess tips that may be required due to a pick-up failure or jam. The tip drawer 4110 can be disposed on the left side of the consumables drawer 4120.

[0044] These drawers 4110, 4120 can be approached by the user from the front of the analyzer 4000. The approach to the drawers 4110, 4120 can be automated. The tip drawer 4110 can be automatically locked or unlocked by the analyzer 4000. According to the current state of the tip drawer 4110, the tip drawer 4110 can be locked or unlocked. The tip drawer 4110 can be locked or unlocked according to the current state of the analyzer 4000. Each drawer 4120 can be automatically locked or unlocked by the analyzer 4000. Each drawer 4120 can be locked or unlocked according to the current state of the drawer 4110. Each drawer 4120 can be locked or unlocked according to the current state of the analyzer 4000. The tip drawer 4110 and one or more drawers 4120 can be locked and unlocked at the same time. The tip drawer 4110 and one or more drawers 4120 can be locked and unlocked independently. The drawers 4110, 4120 may include a latch feature that locks the drawers 4110, 4120 in a fully open position. Drawers 4110, 4120 may include latch features that lock drawers 4110, 4120 in a fully closed position. Drawers 4110, 4120 may include latch features that lock drawers 4110, 4120 in a fully open position and a fully closed position. The latch mechanism may be a push-to-close latch. The latch mechanism may be fully closed by a simple push or other action of the user. The latch mechanism may be spring loaded. The latch mechanism may securely hold drawers 4110, 4120 within the analyzer 4000. The latch mechanism may be built-in. The latch mechanism may include a trigger biased toward a locking configuration. Pressing the trigger may unlock the drawer. The trigger may be automatically pressed by a module of the analyzer 4000. The user may press the trigger. Drawer 4120 may be considered a single-channel drawer. Drawer 4120 may include a latch mechanism for locking and unlocking drawer 4120.

[0045] Return to reference Figure 2 , the auxiliary platform 4012 is disposed near the bottom of the analyzer 4000 and is located below the processing platform 4014. The auxiliary platform 4012 houses electronic components and waste storage. For example, the auxiliary platform 4012 may include a liquid waste storage 4002 that receives and holds all liquid waste, such as liquid waste from the extraction container 4026 during the extraction process and from the tank assembly 4050 during the emptying process. The auxiliary platform 4012 also includes one or more waste storages 4004 that are seated below each waste chute 4210 extending through the processing platform 4014, such as Figure 4AAs shown. For example, a single waste reservoir 4004 can be located below the waste chute 4210 and can collect all solid waste. In another example, two waste reservoirs 4004 can be used to collect used pipette tips and used amplification plates 4040, respectively. Each waste reservoir 4004 can include a sensing device for detecting waste levels. The sensing device can include, for example, an optical or ultrasonic sensor.

[0046] In the illustrated embodiment, the processing platform 4014 includes six consumable drawer assemblies 4120. Each drawer assembly 4120 is a single-channel drawer. There are six drawers 4120 in total. In some cases, this drawer arrangement increases costs and needs to reduce costs. In some cases, this drawer arrangement is complicated for manufacturing or technical maintenance, and needs to reduce the complexity of manufacturing and technical maintenance. For example, each drawer 4120 includes its own extractor module 4125. For another example, each drawer 4120 includes its own latch feature. Therefore, it is necessary to reduce components, thereby reducing the cost associated with the drawer assembly. The drawer described herein may include any feature of the drawer 4120.

[0047] Figures 5A-5C 4130 and a corresponding extractor module 4135 according to the present disclosure. The dual channel drawer 4130 may include any of the features of the drawer 4120. The dual channel drawer 4130 may include advantageous features. The dual channel drawer 4130 may be more cost-effective. The dual channel drawer 4130 may hold the same number of consumables as two drawers 4120. The dual channel drawer 4130 may advantageously have only one extractor module 4135. The dual channel drawer 4130 may advantageously have only one set of telescoping slides to facilitate movement of the dual channel drawer 4130. The dual channel drawer 4130 may advantageously have only one indicator related to the use of the dual channel drawer 4130. The dual channel drawer 4130 may advantageously have only one latch feature that prevents withdrawal of the dual channel drawer 413 during use. The dual channel drawer 4130 may advantageously have only one retaining feature to retain consumables within the dual channel drawer 4130. Return to Reference Figure 4A, analyzer 4000 may include six consumable channels with six drawers 4120, six corresponding extractor modules 4125, and six corresponding latch mechanisms. Utilizing dual channel drawers 4130, the same analyzer 4000 may maintain six consumable channels, but utilize only three of the dual channel drawers 4130, three extractor modules 4135, and three corresponding latch mechanisms. Dual channel drawers 4130 may reduce the number of parts. Dual channel drawers 4130 may reduce costs. Dual channel drawers 4130 may reduce the complexity of manufacturing and technical maintenance. Dual channel drawers 4130 do not affect total throughput because the number of consumables is the same, and therefore the number of samples processed is the same. Dual channel drawers 4130 do not affect customer departure time because the number of consumables is the same, and therefore the number of samples processed is the same.

[0048] The dual channel drawer 4130 is configured to accommodate most of the consumables used in the assay workflow. The dual channel drawer 4130 may include a pipette tip station 4134. The dual channel drawer 4130 may include an extraction container station 4136. The dual channel drawer 4130 may include an amplification plate station 4138. The pipette tip station 4134 is configured to hold two pipette tip holders 4060. The extraction container station 4136 is configured to hold two extraction container holders 4020. The amplification plate station 4138 is configured to hold two amplification plates 4040. The dual channel drawer 4130 may be configured to hold the same types of consumables described herein. The dual channel drawer 4130 may hold twice as many consumables as the drawer 4120.

[0049] Stations 4134, 4136, 4138 may be arranged linearly. The arrangement may be from front to back, with the pipette tip station 4134 in the front, the extraction container station 4136 in the middle, and the amplification plate station 4138 in the back. The dual channel drawer 4130 may hold two pipette tip holders 4060 side by side in the front. The dual channel drawer 4130 may hold two extraction container holders 4020 side by side in the middle. The dual channel drawer 4130 may hold two amplification plates 4040 side by side in the back.

[0050] This arrangement can allow consumables to interface with other components of the analyzer 4000. The analyzer 4000 may include three of the dual channel drawers 4130. The dual channel drawer 4130 may be seated at the front of the analyzer 4000 between the two detectors 4260a, 4260b. The extraction container station 4136 may facilitate the extraction of polynucleotides from the sample. The extraction container station 4136 may be positioned relative to the extractor module 4135. Once the extraction is complete, the polynucleotides extracted in the extraction container 4026 are used to rehydrate the reagents in one of the amplification plates 4040 in the amplification plate station 4138, such as the master mixing reagent. The amplification plate 4040 may be prepared for amplification, such as PCR. The prepared amplification plate 4040 may be moved to appropriate readers 4260a, 4260b. The process may be achieved by using a multifunctional robot 4300, a plate sealer 4220, and an orbital mixer 4230. The dual channel drawer 4130 may include a visual indicator indicating the current state of the dual channel drawer 4130.

[0051] The dual channel drawer 4130 accommodates the extractor module 4135 within the housing 4132. The dual channel drawer 4130 may include one extractor module 4135. In some embodiments, the extractor module 4135 may process samples from two channels simultaneously. In some embodiments, the extractor module 4135 may process samples from two extraction container holders 4020 simultaneously. In some embodiments, the extractor module 4135 may process samples twice the number of samples of the extractor module 4125. The extractor module 4135 may move up and down relative to the two extraction container holders 4020 simultaneously. In some embodiments, the extractor module 4135 may process samples from two channels sequentially, for example, depending on when the sample is inserted into the extraction container 4026. In some embodiments, the extractor module 4135 may process samples from two extraction container holders 4020 sequentially. In some embodiments, the extractor module 4135 may process samples from two channels independently, for example, depending on when the sample is inserted into the extraction container 4026. In some embodiments, the extractor module 4135 can independently process samples from two extraction container holders 4020. In some embodiments, the pipette extracts polynucleotides from only one of the extraction container holders 4020. In some embodiments, the workflow does not process samples from both extraction container holders 4020. The software can be limited to process one extraction container holder 4020. The pipette can be limited to process one extraction container holder 4020. The instrument can be limited to process one extraction container holder 4020. The workflow timing can be limited to process one extraction container holder 4020.

[0052] The extractor module 4135 includes a magnet 4136. The magnet 4136 can be arranged to apply a magnetic field on opposite sides of the extraction container. The magnet 4136 provides a magnetic field for extracting polynucleotides from a sample. The extractor module 4135 is movable vertically. The extractor module 4135 can move the magnet 4136 and thereby move the corresponding magnetic field relative to the extraction container 4026 of the two extraction container holders 4020 located in the extraction container station 4136. The extractor module 4135 can be positioned below the extractor container station 4136. The extractor module 4135 can be selectively moved in the up and down directions along one or more guide rails 4137. The guide rail 4137 can be set on a side wall that separates the extraction container station 4136 and the amplification plate station 4138. As shown in FIG. Figure 5C 4130. As shown, the extractor module 4135 is in an extended position. The magnet 4136 can be near the extraction container 4026. The extractor module 4135 can be lowered below the extraction container 4026. The extractor module 4135 is housed in the dual channel drawer 4130. In some embodiments, the analyzer 4000 can include three and three extractor modules 4135 in the dual channel drawer 4130.

[0053] This movement of the magnet 4136 of the extractor module 4135 can facilitate the processing of the sample. To help separate the polynucleotides extracted from the sample, the polynucleotides can be bound to iron oxide ("FOX") particles located in the extraction container 4026. The particles allow the polynucleotides to be magnetically captured. This enables the polynucleotides to be separated from the remaining unwanted sample, which can be washed away from the eluent using a wash buffer located in the slot assembly 4050. To perform this separation, a magnetic field is applied to the extraction containers 4026 of the two extraction container holders 4020. The magnetic field is applied by using the extractor module 4135. The extractor module 4135 includes magnets 4136, which are positioned to ensure that each row of extraction containers 4026 is subjected to a magnetic field. In some embodiments, the magnets 4136 are disposed on both sides of the extraction container 4026. The magnets 4136 are selectively moved from a position completely below the extraction container 4026 to a position adjacent to the extraction container 4026. In some embodiments, the magnets 4136 can generally be located in one plane. Extraction container 4026 can intersect this plane in extraction mode. In other modes, extraction container 4026 can be completely below this plane. In some embodiments, magnet 4136 overlaps extraction container 4026. Extractor module 4135 applies a magnetic field to one side of extraction container 4026 that captures bound polynucleotides.

[0054] The dual channel drawer 4130 may include a hinged retaining feature 4131. The retaining feature 4131 may be a spring loaded plate. The retaining feature 4131 may be hingedly connected to the housing 4132. The hinge 4133 of the retaining feature 4131 may be positioned behind the extraction container station 4136. The hinge 4133 of the retaining feature 4131 may be positioned in front of the amplification plate station 4138. The retaining feature 4131 has a retaining position and a consumable replacement position. In the retaining position, as shown in FIG. Figure 5A As shown, the retaining feature 4131 extends over the pipette tip station 4134 and the extraction container station 4136. In this position, the retaining feature 4131 is configured to extend over at least a portion of the two pipette tip holders 4060 and the two extraction container holders 4020 located in the pipette tip station 4134 and the extraction container station 4136, respectively. The retaining feature 4131 can cover the periphery of the two pipette tip holders 4060 and the periphery of the two extraction container holders 4020 while allowing access via the opening in the retaining feature 4130. The retaining feature 4131 acts as a cover to limit the movement of the two extraction container holders 4020 and the two pipette tip holders 4060 during operations such as pipetting operations. The hinged retaining feature 4131 can include a locking feature that locks the retaining feature 4131 in a retaining position.

[0055] When it is necessary to remove the consumables in the dual channel drawer 4130 and replace them with new consumables, the dual channel drawer 4130 can be extended. The locking feature that locks the retaining feature 4131 in the retaining position can be released when the dual channel drawer 4130 is extended. The locking feature that locks the retaining feature 4131 in the retaining position can be a magnet. When the dual channel drawer 4130 is opened, the retaining feature 4131 can also be lifted. The retaining feature 4131 does not rely on the extension of the dual channel drawer 4130. Under the bias of the torsion spring, the retaining feature 4131 can rotate around the hinge 4133 to the consumable replacement position. The consumable replacement position opens the retaining feature 4131 to provide a gap for the user to replenish the consumables in the dual channel drawer 4130. The dual channel drawer 4130 can be extended along a telescopic slide. The dual channel drawer 4130 can include an assembly of extensions that slide relative to each other. The slide can be metal. The slide can include ball bearings. The slide can be a complete extension slide. The slide can be extended in sections. The slide can be extended in stages. The housing 4132 of the dual channel drawer 4130 may include a tab and slot weldment. The tab and slot arrangement may connect one surface to another surface through an elongated hole.

[0056] The dual channel drawer 4130 may include a latch feature that locks the dual channel drawer 4130 to prevent the dual channel drawer 4130 from extending from the analyzer 4000. The dual channel drawer 4130 may include a latch feature that locks the dual channel drawer 4130 in a fully open position. The dual channel drawer 4130 may include a latch feature that locks the dual channel drawer 413 in a fully closed position. The latch mechanism may be a push-to-close latch. In some embodiments, the latch mechanism is not locked in an open position. In some embodiments, the latch mechanism is not suitable for being locked in an open position. In some embodiments, the latch mechanism can be locked in an open position with different telescopic slides. The latch mechanism can be fully closed by a simple push or other action of the user. The latch mechanism may be spring loaded. The latch mechanism can securely hold the dual channel drawer 4130 in the analyzer 4000. The latch mechanism may be built-in. The latch mechanism may include a trigger biased toward a locking configuration. Pressing the trigger may unlock the drawer. The trigger may be automatically pressed by a module of the analyzer 4000. The user may press the trigger. The dual channel drawer 4130 may include a latch mechanism for locking and unlocking the dual channel drawer 4130.

[0057] The dual channel drawer 4130 may include a pop-up mechanism. The pop-up mechanism may promote the sliding extension of the dual channel drawer 4130. The pop-up mechanism may extend along the bottom of the dual channel drawer 4130. The purpose of the pop-up mechanism may be to open the dual channel drawer 4130 at least a short distance after the dual channel drawer 4130 has been unlocked, so as to approach the handle. The pop-up mechanism may open the dual channel drawer 4130 by 0.5 inch, 1 inch, 1.5 inches, 2 inches, 2.5 inches, 3 inches, 3.5 inches, 4 inches, at least 0.5 inch, at least 1 inch, at least 1.5 inches, at least 2 inches, at least 2.5 inches, at least 3 inches, at least 3.5 inches, at least 4 inches, or any range of two of the aforementioned values. In certain embodiments, the pop-up mechanism may open the dual channel drawer by at least two inches. The purpose of the pop-up mechanism may be to push the dual channel drawer 4130 to the latch to realize position repeatability when locked. In certain embodiments, the pop-up mechanism may not release the latch mechanism. In certain embodiments, the user does not interact with the pop-up mechanism. The pop-up mechanism can allow the dual channel drawer 4130 to slide relative to the analyzer 4000.

[0058] Figures 6A-6C is a view of a dual channel drawer 4130 relative to an analyzer 4000 according to the present disclosure. Fig. 6Ais an example of an analyzer 4000. The analyzer 4000 can include three of the dual channel drawers 4130. The dual channel drawers 4130 can hold consumables as described herein. The analyzer 4000 can include a tip drawer 4110. The tip drawer 4110 can hold a pipette tip holder 4060 as described herein.

[0059] Figure 6B 4011 is a view of an analyzer 4000 including a structural frame 4011 that is configured to support and define various platforms or levels for sample processing and analysis. As described herein, the analyzer 4000 may include an auxiliary platform 4012, a processing platform 4014, and a multi-purpose robotic platform 4016. Fig. 6A As shown, analyzer 4000 may include a housing or casing surrounding internal components.

[0060] Figures 6A-6C An analyzer 4000 including three of the dual channel drawers 4130 is shown. The dual channel drawers 4130 may be adjacent. The dual channel drawers 4130 may slide relative to a single drawer plate 4140. When the dual channel drawers 4130 are pulled out individually relative to the plate 4140, the drawer plate 4140 may remain stationary. The dual channel drawers 4130 may extend relative to the drawer plate 4140. Each of the dual channel drawers 4130 may slide relative to the drawer plate 4140. Each of the dual channel drawers 4130 may include a telescopic slide to allow the dual channel drawer 4130 to slide relative to the drawer plate 4140. Each dual channel drawer 4130 may slide independently of another dual channel drawer 4130. Each dual channel drawer 4130 may slide sequentially with another dual channel drawer 4130. Each dual channel drawer 4130 may slide simultaneously with another dual channel drawer 4130. Each dual channel drawer 4130 may include a latch mechanism. Each dual channel drawer 4130 may include an eject mechanism. Each dual channel drawer 4130 may include a retaining feature 4131 that extends over a corresponding pipette tip station 4134 and extraction container station 4136. The dual channel drawers 4130 may be identical. The dual channel drawers 4130 may be stacked side by side. The dual channel drawers 4130 may include a tab and slot weldment.

[0061] Figure 74 is a view of an embodiment of a dual-channel drawer 4150 according to the present disclosure. The dual-channel drawer 4150 may include any features of the drawers described herein. The dual-channel drawer 4150 may be used in combination with the extractor module 4135. The dual-channel drawer 4150 may hold the same number of consumables as the dual-channel drawer 4130. The dual-channel drawer 4150 may hold the same number of consumables as the two drawers 4120. Similar to the drawer 4130, the dual-channel drawer 4150 has only one extractor module. Similar to the drawer 4130, the dual-channel drawer 4150 has only one latch feature. This results in being able to hold six channels of consumables, but only three extractors. This results in being able to accommodate six channels of consumables, but only three latch features. The dual-channel drawer 4150 may reduce the number of parts. The dual-channel drawer 4150 may reduce costs. The dual-channel drawer 4150 may reduce the complexity of manufacturing and technical maintenance.

[0062] The dual channel drawer 4150 is configured to accommodate most of the consumables used in the assay workflow. The dual channel drawer 4150 includes a pipette tip station 4154, an extraction container station 4156, and an amplification plate station 4158. The pipette tip station 4154 is configured to hold two pipette tip holders 4060. The extraction container station 4156 is configured to hold two extraction container holders 4020. The amplification plate station 4158 is configured to hold two amplification plates 4040.

[0063] The analyzer 4000 can include a fixed holding housing 4161. In the depicted embodiment, the fixed holding housing 4161 can be a cover positioned relative to the dual channel drawer 4150. The fixed holding housing 4161 extends over the pipette tip station 4154 and the extraction container station 4156. In this position, the fixed holding housing 4161 is configured to extend over at least a portion of two pipette tip holders 4060 and at least a portion of two extraction container holders 4020 located in the pipette tip station 4154 and the extraction container station 4156, respectively. The fixed holding housing 4161 can cover the perimeter of the two pipette tip holders 4060 and the two extraction container holders 4020 while allowing access to the two pipette tip holders 4060 and the two extraction container holders 4020 via an opening in the fixed holding housing 4161. The fixed holding housing 4161 serves to limit the movement of the extraction container holder 4020 and the pipette tip holder 4060 during operation. In some embodiments, the fixed holding housing 4161 does not cover the amplification plate 4040 located in the amplification plate station 4158. The fixed holding housing 4161 can be fixed relative to the drawer plate 4160. The dual channel drawer 4150 can be extended relative to the drawer plate 4160.

[0064] When the consumables in the drawer 4150 need to be removed and replaced with new consumables, the dual channel drawer 4150 is extended while the fixed retention housing 4161 does not move relative to the dual channel drawer 4150. The dual channel drawer 4150 slides relative to the fixed retention housing 4161. The dual channel drawer 4150 may include a latch feature. The dual channel drawer 4150 may include an eject mechanism. The dual channel drawer 4150 may be extended along a telescopic slide. The fixed retention housing 4161 may include a sheet metal having a wing and slot weldment.

[0065] Figure 8 41 is a view of an embodiment of a three-channel drawer 4170 according to the present disclosure. The three-channel drawer 4170 may include any features of the drawers described herein. The three-channel drawer 4170 may be used in combination with an extractor module. The extractor module may move relative to the three channels. In some embodiments, the extractor module may apply a magnetic field to the three extraction container holders 4020. The three-channel drawer 4170 may hold the same number of consumables as the three drawers 4120. The three-channel drawer 4170 may have only one extractor module. The three-channel drawer 4170 may have only one latch feature. This results in the ability to accommodate six channels of consumables, but only two extractors and two latch mechanisms. The three-channel drawer 4170 may reduce the number of parts. The three-channel drawer 4170 may reduce costs. The three-channel drawer 4170 may reduce the complexity of manufacturing and technical maintenance.

[0066] The three-channel drawer 4170 is configured to accommodate most of the consumables used in the assay workflow. The three-channel drawer 4170 includes a pipette tip station 4174, an extraction container station 4176, and an amplification plate station 4178. The pipette tip station 4174 is configured to hold three pipette tip holders 4060. The extraction container station 4176 is configured to hold three extraction container holders 4020. The three extraction container holders 4020 can be placed side by side. The amplification plate station 4178 is configured to hold three amplification plates 4040.

[0067] The analyzer 4000 may include a fixed holding housing 4181. The fixed holding housing 4181 may be a fixed cover positioned relative to the three-channel drawer 4170. The fixed holding housing 4181 extends over the pipette tip station 4174 and the extraction container station 4176. In this position, the fixed holding housing 4181 is configured to extend over at least a portion of the three pipette tip holders 4060 and at least a portion of the three extraction container holders 4020 located in the pipette tip station 4174 and the extraction container station 4176, respectively. The fixed holding housing 4181 may cover the periphery of the pipette tip holder 4060 and the periphery of the extraction container holder 4020 while allowing access to the pipette tip holder 4060 and the extraction container holder 4020 via an opening in the fixed holding housing 4181. The fixed holding housing 4181 functions to limit the movement of the extraction container holder 4020 and the pipette tip holder 4060 during operation. In some embodiments, the fixed retaining housing 4181 does not cover the amplification plate 4040 located in the amplification plate station 4178.

[0068] When the consumables in the three-channel drawer 4170 need to be removed and replaced with new consumables, the three-channel drawer 4170 is extended while the fixed retention housing 4181 does not move relative to the three-channel drawer 4170. The three-channel drawer 4170 may include a latch feature. The three-channel drawer 4170 may include an eject mechanism. The three-channel drawer 4170 may be extended along a telescopic slide. The fixed retention housing 4181 may include a sheet metal having a wing and slot weldment.

[0069] Figures 9A-9B 41 is a view of an embodiment of a six-channel drawer 4190 according to the present disclosure. The six-channel drawer 4190 can be used in combination with the tip drawer 4110. The tip drawer 4110 can be configured to hold a plurality of pipette tip holders 4060. The tip drawer 4110 can accommodate five pipette tip holders 4060. The six-channel drawer 4190 and the tip drawer 4110 can be arranged side by side. In some embodiments, the six-channel drawer 4190 and the tip drawer 4110 can be integral. The six-channel drawer 4190 and the tip drawer 4110 can be moved together to extend from the analyzer 4000.

[0070] The six-channel drawer 4190 may include any of the features of the drawers described herein. The six-channel drawer 4190 may be used in combination with an extractor module. The extractor module may move relative to the six channels. The extractor module may apply a magnetic field to one extraction container holder 4020. The extractor module may apply a magnetic field to two or three extraction container holders 4020. The extractor module may apply a magnetic field to six extraction container holders 4020. The extractor module may move along an axis relative to the six-channel drawer 4190. The extractor module may include a slide 4270. The slide 4270 may be a guide rail along which the extractor module slides. Fig. 10A Slide 4270 is described in more detail. Six extraction container holders 4020 can be placed side by side. Six-channel drawer 4190 can hold the same number of consumables as six drawers 4120. Six-channel drawer 4190 can have only one extractor module. Six-channel drawer 4190 can have only one latch feature. This results in being able to accommodate six channels of consumables, but with only one extractor module and one latch mechanism. Six-channel drawer 4190 can reduce the number of parts. Six-channel drawer 4190 can reduce costs. Six-channel drawer 4190 can reduce the complexity of manufacturing and technical maintenance.

[0071] The six-channel drawer 4190 is configured to accommodate most of the consumables used in the assay workflow. The six-channel drawer 4190 includes a pipette tip station 4194, an extraction container station 4196, and an amplification plate station 4198. The pipette tip station 4194 is configured to hold six pipette tip holders 4060. The extraction container station 4196 is configured to hold six extraction container holders 4020. The amplification plate station 4198 is configured to hold six amplification plates 4040.

[0072] The analyzer 4000 may include a fixed holding housing 4115. The fixed holding housing 4115 may be a single unitary structure extending over the tip drawer 4110, at least a portion of the pipette tip station 4191, and at least a portion of the extraction container station 4196. The fixed holding housing 4115 may be a fixed cover positioned relative to the tip drawer 4110. The fixed holding housing 4115 may be a fixed cover positioned relative to the six-channel drawer 4190. The fixed holding housing 4115 may extend over the pipette tip station 4194 and the extraction container station 4196. In this position, the fixed holding housing 4115 is configured to extend over at least a portion of the six pipette tip holders 4060 located in the pipette tip station 4194 of the six-channel drawer 4190. In this position, the fixed holding housing 4115 is configured to extend over at least a portion of the five pipette tip holders 4060 of the tip drawer 4110. In this position, the fixed holding housing 4115 is configured to extend over at least a portion of the six extraction container holders 4020 respectively located in the extraction container station 4196. The fixed holding housing 4115 can be a single integral structure that holds consumables within the tip drawer 4110 and the six channel drawer 4190.

[0073] The fixed holding housing 4115 can cover the periphery of the pipette tip holder 4060 and the periphery of the extraction container holder 4020, while allowing access to the pipette tip holder 4060 and the extraction container holder 4020 via the opening in the fixed holding housing 4115. The role of the fixed holding housing 4115 is to limit the movement of the extraction container holder 4020 and the pipette tip holder 4060 during operation. In some embodiments, the fixed holding housing 4115 does not cover the amplification plate 4040 located in the amplification plate station 4198. The fixed holding housing 4115 may include a section for the tip drawer 4110. The fixed holding housing 4115 may include a metal sheet with a fin and a slot weldment. The fixed holding housing 4115 may include a separate top plate mounted on the outside of the support. The fixed holding housing 4115 may include a support mounted to the side of the base 4116. The fixed holding housing 4115 may include a vertical support to resist warping.

[0074] When it is necessary to remove the consumables in the six-channel drawer 4190 and replace them with new consumables, the six-channel drawer 4170 is extended, while the fixed holding housing mechanism 4115 does not move relative to the six-channel drawer 4190. The six-channel drawer 4190 may include a latch feature. The six-channel drawer 4190 may include a pop-up mechanism. The six-channel drawer 4190 can be extended along a telescopic slide. In some embodiments, each channel of the six-channel drawer 4190 slides together. The six-channel drawer 4190 may include a single drawer front. In an alternative embodiment not shown, when each channel is associated with a corresponding one of the multiple drawer fronts, each channel of the six-channel drawer 4190 can slide separately. Each channel can include a separate sliding sub-drawer. The six-channel drawer 4190 can be associated with an extractor having any of the features described herein. In some embodiments, when running on the channel, the extractor can move upward and lock the channel so that the channel cannot be opened.

[0075] Figures 10A-10C 4200. The extractor module 4200 can be used with any of the drawers described herein. The extractor module 4200 can include a scissor lift design. The scissor lift can include a platform or plate 4202. The plate 4202 can be coupled to a plurality of magnets 4204. As described herein, the magnets 4204 can apply a magnetic field to the extraction containers 4026 of the extraction container holder 4020. The plate 4202 can include magnets 4204 configured to apply a magnetic field to the extraction containers 4026 positioned in a single channel. The plate 4202 can include magnets configured to apply a magnetic field to a single extraction container holder 4020. The scissor lift can include a base 4206. The base 4206 and the plate 4202 can be structures having the same or similar shapes. The base 4206 and the plate 4202 can have a mirrored configuration. The scissor lift can move in a vertical direction. The scissor lift can include scissor legs 4208. The scissor legs 4208 are cross struts that bridge the gap between the base 4206 and the plate 4202. One of the scissor legs 4208 is fixed to the plate 4202 and can move relative to the base 4206. The other scissor leg 4208 is fixed to the base 4206 and can move relative to the plate 4202. The scissor lift moves upward by extending the scissor legs 4208 from a generally horizontal orientation to a generally vertical orientation. The scissor lift moves downward by extending the scissor legs 4208 from a generally vertical orientation to a generally horizontal orientation. The extractor module 4200 can include a slide 4270. The slide 4270 can allow the extractor module 4200 to move relative to the corresponding drawer. The extractor module 4200 can include a linear drive 4272. The linear drive 4272 can move the extractor module 4200 relative to the slide 4270.

[0076] Fig. 10B The extractor module 4200 is shown relative to the dual channel drawer 4130. Fig. 10B Three of the dual channel drawers 4130 are shown. The extractor module 4200 can be used with any of the drawers described herein. The extractor module 4200 can be used with the three channel drawer 4170. The extractor module 4200 can be used with the six channel drawer 4190. The dual channel drawer 4130 can include an extraction container station 4136. The extraction container station 4136 can hold two extraction container holders 4020. The extraction container holders 4020 can be side by side. Fig. 10B As shown, the extractor module 4200 can be in a first position to apply a magnetic field to the first extraction container holder 4020 of the first dual channel drawer 4130. The extractor module 4200 can move up and down relative to the first extraction container holder 4020 in the first position. The extractor module 4200 can apply a magnetic field to a single extraction container holder 4020 in the extraction container station 4136 of the first dual channel drawer 4130. The extractor module 4200 can move from the first position to the second position. The extractor module 4200 can be in a second position to apply a magnetic field to the second extraction container holder 4020 of the first dual channel drawer 4130. The extractor module 4200 can move along the slide 4270 to the second extraction container holder 4020. The extractor module 4200 can move up and down relative to the second extraction container holder 4020 in the second position.

[0077] The extractor module 4200 may be moved along the slide 4270 to the second dual channel drawer 4130. The extractor module 4200 may be moved from the second position to the third position. The extractor module 4200 may be in the third position to apply a magnetic field to the third extraction container holder 4020 of the second dual channel drawer 4130. The extractor module 4200 may be moved along the slide 4270 to the third extraction container holder 4020. The extractor module 4200 may be moved up and down relative to the third extraction container holder 4020 at the third position. The extractor module 4200 may be moved from the third position to the fourth position. The extractor module 4200 may be in the fourth position to apply a magnetic field to the fourth extraction container holder 4020 of the second dual channel drawer 4130. The extractor module 4200 may be moved along the slide 4270 to the fourth extraction container holder 4020. The extractor module 4200 may be moved up and down relative to the fourth extraction container holder 4020 at the fourth position.

[0078] The extractor module 4200 may be moved along the slide 4270 to the third dual channel drawer 4130. The extractor module 4200 may be moved from the fourth position to the fifth position. The extractor module 4200 may be in the fifth position to apply a magnetic field to the fifth extraction container holder 4020 of the third dual channel drawer 4130. The extractor module 4200 may be moved along the slide 4270 to the fifth extraction container holder 4020. The extractor module 4200 may be moved up and down relative to the fifth extraction container holder 4020 at the fifth position. The extractor module 4200 may be moved from the fifth position to the sixth position. The extractor module 4200 may be in the sixth position to apply a magnetic field to the sixth extraction container holder 4020 of the third dual channel drawer 4130. The extractor module 4200 may be moved along the slide 4270 to the sixth extraction container holder 4020. The extractor module 4200 may be moved up and down relative to the sixth extraction container holder 4020 at the sixth position. The extractor module 4200 can be moved from the sixth position back to the first position, and between any two positions of the first, second, third, fourth, fifth or sixth position. Although the extractor module 4200 is shown as being associated with three of the dual channel drawers 4130, the extractor module 4200 can be used with any drawer described herein.

[0079] Fig. 10A The extractor module 4200 is shown in an extended or upward configuration. Fig. 10CThe extractor module 4200 in a collapsed or downward configuration is shown. The extractor module 4200 can move up and down to change the position of the extraction container 4026 of the extraction container holder 4020 with respect to the magnetic field. The assembly can include three of the dual channel drawers 4130. The dual channel drawers 4130 can be placed side by side. In some embodiments, each dual channel drawer 4130 can include an extractor module 4200. The assembly can include three extractor modules 4200. The extractor module 4200 can move between the channels of the dual channel drawers 4130. In some embodiments, the assembly can include one extractor module 4200. The extractor module 4200 can move between all dual channel drawers 4130. The extractor module 4200 can move between three of the dual channel drawers 4130. The extractor module 4200 can move between all six channels. In some methods of use, after applying a magnetic field to the extraction container holder 4020 in the first dual channel drawer 4130, the extractor module 4200 can collapse relative to the first dual channel drawer 4130. The extractor module 4200 may then move to the second dual channel drawer 4130, then extend to apply a magnetic field to the extraction container holder 4020 in the second dual channel drawer 4130, and then collapse relative to the second dual channel drawer 4130. The extractor module 4200 may then move to the third dual channel drawer 4130, then extend to apply a magnetic field to the extraction container holder 4020 in the third dual channel drawer 4130, and then collapse relative to the third dual channel drawer 4130. The extractor module 4200 may move to any dual channel drawer 4130 in any order.

[0080] Fig.11 is a view of an extractor module 4300 according to the present disclosure. The extractor module 4300 can be used with any of the drawers described herein. The extractor module 4300 can include a pusher design. The pusher can include a platform or plate 4302. The plate 4302 can be coupled to a plurality of magnets 4304. The plate 4302 can include magnets 4304. The magnets 4304 apply a magnetic field to the extraction container 4020. The magnets 4304 can be arranged to apply a magnetic field to two channels. The magnets 4304 can be arranged to apply a magnetic field to two extraction container holders 4020. In some embodiments, the plate 4302 with the magnets 4304 can remain in the dual channel drawer 4130 at all times. In some embodiments, there can be one plate 4302 with the magnets 4304 in each dual channel drawer 4130. The extractor module 4300 can include pusher arms 4308. The pusher arms 4308 can be as Fig.11 4302 to move the plate 4302 upward and can be rotated counterclockwise as shown in Fig.114302 is rotated clockwise as shown in the figure to move the plate 4302 downward. The drawer 4130 may include a plate 4310 having a slot 4312 through which the pusher arm 4308 rotates. The extractor module 4300 may include a slide 4370. The slide 4370 may allow the extractor module 4300 to move relative to the corresponding drawer. The extractor module 4300 may include a linear drive 4372. The linear drive 4372 may move the extractor module 4300 relative to the slide 4370. In some embodiments, the magnet 4304 is not directly attached to the linear drive 4372 or the pusher arm 4308.

[0081] Fig.11 The extractor module 4300 is shown relative to the dual channel drawer 4130. The dual channel drawer 4130 includes a pipette tip station 4134, an extraction container station 4136, and an amplification plate station 4138. The pipette tip station 4134 is configured to hold two pipette tip holders 4060. The extraction container station 4136 is configured to hold two extraction container holders 4020. The amplification plate station 4138 is configured to hold two amplification plates 4040. The extraction containers 4020 can be side by side. The extractor module 4300 can be in an upward position to apply a magnetic field to the first extraction container holder 4020 and the second extraction container holder 4020. The extractor module 4300 can move up and down relative to the extraction container holder 4020. The extractor module 4300 can apply a magnetic field to the two extraction container holders 4020 in the extraction container station 4136.

[0082] Return to reference Figure 6C, the assembly may include three of the dual channel drawers 4130. The dual channel drawers 4130 may be placed side by side. The extractor module 4300 may collapse relative to the first dual channel drawer 4130. The extractor module 4300 may move to the second dual channel drawer 4130. The extractor module 4300 may move to the second dual channel drawer 4130 along the slide 4370. The extractor module 4200 may be in a second position to apply a magnetic field to the extraction container holder 4020 of the second dual channel drawer 4130. The extractor module 4300 may move up and down relative to the second dual channel drawer 4130 in the second position. The extractor module 4300 may collapse relative to the second dual channel drawer 4130. The extractor module 4300 may move to the third dual channel drawer 4130. The extractor module 4300 may move to the third dual channel drawer 4130 along the slide 4370. Extractor module 4200 can be in the third position to apply a magnetic field to the extraction container holder 4020 of the third dual channel drawer 4130. Extractor module 4300 can move up and down relative to the third dual channel drawer 4130 in the third position. Although extractor module 4300 is shown as being associated with dual channel drawer 4130, extractor module 4300 can be used with any drawer described herein. Extractor module 4300 can be moved between drawers. Extractor module 4300 can reduce the total number of extractor modules required in the multi-drawer assembly of analyzer 4000. Extractor module 4300 can reduce costs. Extractor module 4300 can reduce complexity and manufacturing complexity. This can allow one extractor module 4300 to reside in analyzer 4000.

[0083] In some embodiments, a dual channel drawer assembly is provided. The dual channel drawer assembly may include a dual channel drawer. The dual channel drawer may include a pipette tip station configured to accommodate two pipette tip holders. The dual channel drawer may include an extraction container station configured to accommodate two extraction container holders. The dual channel drawer may include an amplification plate station configured to accommodate two amplification plates. The dual channel drawer assembly may include an extractor module positioned relative to the extraction container station. In some embodiments, the extractor module includes a magnet configured to apply a magnetic field to an extraction container holder in the two extraction container holders.

[0084] In some embodiments, the extractor module is configured to process samples from an extraction container holder. In some embodiments, the extractor module is configured to move up and down relative to two extraction container holders. In some embodiments, the extractor module is configured to move up and down along one or more guide rails. In some embodiments, the dual channel drawer includes a retention feature that is configured to extend above a portion of the pipette tip station and the extraction container station. In some embodiments, the dual channel drawer includes a latch mechanism that includes a push-to-close latch. In some embodiments, the dual channel drawer includes an ejection mechanism that is configured to facilitate the sliding extension of the dual channel drawer. In some embodiments, the dual channel drawer includes a telescopic slide. In some embodiments, the dual channel drawer assembly may include two pipette tip holders, two extraction container holders, and two amplification plates. In some embodiments, the dual channel drawer assembly may include three of the dual channel drawers. In some embodiments, the dual channel drawer assembly may include a tip drawer configured to accommodate five pipette tip holders.

[0085] The above description is intended to illustrate various aspects of the present technology. The examples presented herein are not intended to limit the scope of the present technology. It will be apparent to one of ordinary skill in the art that many changes and modifications may be made to the technology now fully described without departing from the spirit or scope of the appended claims.

Claims

1. A dual channel drawer assembly, characterized in that: The dual-channel drawer assembly comprises: Double channel drawer, which includes: a pipette tip station configured to accommodate two pipette tip holders; an extraction container station configured to accommodate two extraction container holders; and an amplification plate station configured to accommodate two amplification plates; An extractor module positioned relative to the extraction container station, wherein the extractor module includes a magnet configured to apply a magnetic field to an extraction container holder of the two extraction container holders.

2. The dual channel drawer assembly according to claim 1, characterized in that: The extractor module is configured to process a sample from an extraction container holder.

3. The dual channel drawer assembly according to claim 1, characterized in that: The extractor module is configured to move up and down relative to the two extraction container holders.

4. The dual channel drawer assembly according to claim 1, characterized in that: The extractor module is configured to move up and down along one or more rails.

5. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer includes a retention feature configured to extend over a portion of the pipette tip station and the extraction container station.

6. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer includes a latch mechanism including a push-to-close latch.

7. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer includes a pop-up mechanism configured to facilitate the sliding extension of the dual channel drawer.

8. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer includes telescopic slides.

9. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer assembly further includes the two pipette tip holders, the two extraction container holders, and the two amplification plates.

10. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer assembly further includes three of the dual channel drawers.

11. The dual channel drawer assembly according to claim 1, characterized in that: The dual channel drawer assembly further includes a tip drawer configured to accommodate five pipette tip holders.

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