Gauze microcrystal patch and manufacturing method thereof

Abstract

The invention relates to a gauze microcrystal patch and a manufacturing method thereof, and the manufacturing method comprises the following steps: cutting a raw material gauze into a finger-pressing gauze pad according to a preset shape, brushing glue on the surface of one side of the finger-pressing gauze pad, and forming a first bonding area and a second bonding area on the side surface of the finger-pressing gauze pad; cutting the raw material plastic sheet into a protective membrane with hollow holes according to a preset shape; the protective membrane is bonded to the finger-pressing gauze pad through the first bonding area; manufacturing a soluble microneedle dry sheet, wherein the soluble microneedle dry sheet comprises a substrate and microneedles; an annular cutter in a preset shape is customized, and the soluble microneedle dry sheet is cut into soluble microneedle patches; and the soluble microneedle patch is clamped, so that the substrate is bonded to the second bonding area. According to the gauze microcrystal patch produced through the manufacturing method, the soluble microneedle patch is not prone to being dissolved in advance, the skin care and treatment effects are better, and the gauze microcrystal patch is safer, more sanitary and better in use experience.

Description

Technical Field

[0001] The present application relates to the technical field of soluble microneedles, and in particular to a gauze microcrystal patch and a method for making the same. Background Art

[0002] Soluble microneedles are microneedles made of biodegradable materials as a matrix. In addition to the advantages of general microneedles, their biodegradable properties solve the problem of microneedles being difficult to handle once they break in the skin. They also increase the drug loading capacity of microneedles to a certain extent and expand the scope of application of microneedles. Therefore, biodegradable microneedles are expected to become ideal carriers for transdermal drug delivery systems and have very good application value.

[0003] Scholars at the University of Georgia in the United States have proposed a method for making biodegradable polymer microneedles by etching glass or using photolithography to form a mold. In the paper "Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug deli very", a method for making soluble microneedles was proposed. This method uses a mold molding method (Micro Molding Method) to make soluble microneedles. The method first uses the Micro Electro Mechanical Systems technology to make a silicon or polymer polydimethylsiloxane mold that can be used for microneedle molding. Then the biodegradable polymer mixed with active substances is poured into the silicon or polydimethylsiloxane microneedle mold by dissolving (hyaluronic acid, hydroxymethyl cellulose, polyvinyl pyrrolidone, etc.) or melting (polyglycolic acid, polylactic acid or polylactic acid-polyglycolic acid copolymer). Finally, the polymer solution is solidified into a microneedle shape through high-temperature vacuum drying and other processes, and finally the solidified microneedle is separated from the mold to complete the production of the microneedle.

[0004] For example, a Chinese patent application numbered 201710119814.0 discloses a method for manufacturing soluble microneedles, including making a microneedle mold having a plurality of microporous cavities, and using a high-pressure spray device to spray a polymer solution into the microporous cavity so that the polymer solution fills each microporous cavity, and after the polymer solution dries, taking out the solidified microneedles from the microneedle mold.

[0005] With respect to the above-mentioned related technologies, the inventor believes that there are the following defects:

[0006] The soluble microneedle patches obtained by conventional production processes are easily dissolved by contact with human skin due to the high temperature of human skin. Therefore, during the process of producing, transporting, transferring and pasting the soluble microneedle patches to the skin, the user's fingers can easily touch the soluble substrate and cause the soluble substrate to melt prematurely. This is not safe and hygienic and the user experience is poor, so it needs to be improved. Summary of the invention

[0007] The present application provides a gauze microcrystalline patch and a manufacturing method thereof to improve the following technical problems:

[0008] The soluble microneedle patches obtained by conventional production processes are easily dissolved by contact with human skin due to the high temperature of human skin. Therefore, during the process of producing, transporting, transferring and pasting the soluble microneedle patches to the skin, the user's fingers can easily touch the soluble substrate and cause the soluble substrate to melt prematurely, which is not safe and hygienic and the user experience is poor.

[0009] In a first aspect, the present application provides a method for making a gauze microcrystalline patch, using the following technical solution:

[0010] A method for making a gauze microcrystalline patch comprises the following steps:

[0011] Step 1: Cut the raw gauze into finger-pressing gauze pieces according to a preset shape, apply glue on one side of the finger-pressing gauze piece, and form a first bonding area and a second bonding area on the side of the finger-pressing gauze piece;

[0012] Step 2: Cut the raw plastic sheet into a protective film sheet with hollow holes according to a preset shape;

[0013] Step 3: Bond the protective film to the finger-pressure gauze sheet through the first bonding area until the outer contour of the protective film completely covers the outer contour of the finger-pressure gauze sheet and the second bonding area is exposed from the hollow hole;

[0014] Step 4: preparing a soluble microneedle dry sheet, wherein the soluble microneedle dry sheet comprises a substrate and microneedles, wherein a plurality of microneedles are arranged in an array on one side of the substrate, and the substrate and the microneedles are integrally formed;

[0015] Step 5: Customize a ring cutter of a preset shape, and use the ring cutter to cut the soluble microneedle dry sheet into soluble microneedle patches by punching up and down, wherein the area of ​​the soluble microneedle patch is smaller than the area of ​​the hollow hole;

[0016] Step 6: Pick up the soluble microneedle patch by wearing leather gloves or using a clamp. After the soluble microneedle patch passes through the hollow hole, the substrate is bonded to the second bonding area to obtain a gauze microcrystal patch.

[0017] Furthermore, in step one, a first die-cutting knife is customized and installed on a first die-cutting machine, the raw gauze is rolled onto a reel to form a gauze roll, the gauze roll is installed on a feed rack of the first die-cutting machine, and the first die-cutting machine is started to automatically die-cut the raw gauze into finger-pressed gauze sheets through the first die-cutting knife.

[0018] Furthermore, the first bonding area is an annular structure and is located at the peripheral edge of the finger pressure gauze piece, and the second bonding area is a plurality of strip structures arranged at intervals, and all the strip structures are located in the middle of the annular structure.

[0019] Furthermore, in step two, a second die-cutting knife is customized and installed on a second die-cutting machine, the raw plastic sheet is rolled onto a reel to form a plastic sheet roll, the plastic sheet roll is installed on a feed rack of the second die-cutting machine, and the second die-cutting machine is started to automatically die-cut the plastic sheet into protective film sheets through the second die-cutting knife.

[0020] Furthermore, in step 4, the following steps are included:

[0021] Step S41: making a PDMS microneedle mold;

[0022] Step S42: preparing a stock solution: processing the drug or skin care component into a small or medium molecular weight substance, and adding it to a sodium hyaluronate solution having a mass concentration of 8-10% according to a preset ratio, and then stirring the solution at a temperature of 38-42° C. for 1.8-2.2 hours, and then removing bubbles from the stirred liquid to obtain a stock solution;

[0023] Step S43, pretreatment of the PDMS microneedle mold: first, ultrasonically clean the PDMS microneedle mold for 15-25 minutes, then ultraviolet disinfect the PDMS microneedle mold for 35-45 minutes, and finally, plasma treat the PDMS microneedle mold;

[0024] Step S44, injecting stock solution into the mold: taking a certain amount of stock solution according to the cavity volume of the PDMS microneedle mold, and injecting it into the cavity of the PDMS microneedle mold, and flattening the stock solution in the cavity of the PDMS microneedle mold, and then removing bubbles from the stock solution in the PDMS microneedle mold;

[0025] Step S45, drying and molding: leaving the PDMS microneedle mold containing the stock solution to stand for 14-16 hours until the stock solution is dried into a sheet;

[0026] Step S46, demoulding: along the opening edge of the PDMS microneedle mold, lift the sheet-like membrane from the cavity of the PDMS microneedle mold to obtain a soluble microneedle dry sheet.

[0027] In the second aspect, the present application provides a gauze microcrystalline patch, which adopts the following technical solution:

[0028] A gauze microcrystalline patch is produced by the above-mentioned production method.

[0029] Furthermore, gripping portions are protrudingly provided on opposite sides of the protective film.

[0030] Furthermore, the outer contour of the protective film sheet exceeds the outer contour of the finger pressure gauze sheet, and the width of the exceeding portion is 1-10 mm.

[0031] Furthermore, a strip-shaped hole is provided in the middle of the acupressure gauze sheet, and a plurality of the soluble microneedle patches are bonded to one acupressure gauze sheet, wherein two of the soluble microneedle patches are respectively located on both sides of the strip-shaped hole.

[0032] Furthermore, the microneedle is a conical structure or a polygonal pyramid structure, and the angle a between the microneedle and the substrate is between 75-105 degrees.

[0033] In summary, the present application includes at least one of the following beneficial technical effects:

[0034] The manufacturing method of the present application has a simple and reasonable process, a relatively low production cost, and is suitable for mass industrial production;

[0035] The use process of the gauze microcrystalline patch produced by the manufacturing method of the present application is roughly as follows: the user clamps the edge of the protective film with fingers, moves the product near the human skin, then peels off the protective film, aligns the hollow hole with the pre-sticking and pleasing of the skin, presses the finger-pressure gauze piece, and makes the microneedles of the soluble microneedle patch penetrate into the skin, after which the soluble microneedle patch will dissolve, so that the medicine or skin care ingredients carried inside it will be released into the skin, and then liquid / paste (similar to essence and other substances) is applied to the outer surface of the finger-pressure gauze piece, so that the liquid / paste will penetrate the finger-pressure gauze piece to contact the skin, play a role in repairing care and dissolving and absorbing the soluble microneedle patch, wait for a period of time after the soluble microneedle patch is completely dissolved, then the finger-pressure gauze piece can be peeled off from the skin and discarded, and then the skin can be cleaned;

[0036] The gauze microcrystal patch and the soluble microneedle patch produced by the preparation method of the present application make full use of the technical principle of transdermal drug delivery / skin care ingredients, and are combined with a finger pressure gauze sheet to apply liquid / paste, which not only facilitates the full absorption of the drug or skin care ingredients, but also has a simple structure, relatively low production cost, and is more convenient to operate and use, which is conducive to large-scale promotion and application; and in the process of producing, transporting, transferring and pasting the soluble microneedle patch on the skin, the finger pressing operation directly contacts the finger pressure gauze sheet, that is, the finger does not directly contact the soluble microneedle patch, so even if there is sweat or water on the finger, it is not easy to cause the soluble microneedle patch to dissolve prematurely, and the skin care and treatment effects are better, safer and more hygienic, and the user experience is better. Brief Description of the Drawings

[0037] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0038] Figure 1 It is a process flow chart of the manufacturing method of the gauze microcrystal patch in the first embodiment of the present application.

[0039] Figure 2 It is a process flow chart of the production process of the soluble microneedle dry sheet in the first embodiment of the present application.

[0040] Figure 3 It is an exploded structural schematic diagram of the gauze microcrystal patch in the first embodiment of the present application.

[0041] Figure 4 It is a structural schematic diagram of the soluble microneedle patch in the first embodiment of the present application.

[0042] Figure 5 It is an exploded structural schematic diagram of the gauze microcrystal patch in the second embodiment of the present application.

[0043] Description of the reference numerals:

[0044] 1. Protective film sheet; 11. Hollow hole; 12. Grasping part;

[0045] 2. Finger-pressure gauze sheet; 21. First bonding area; 22. Second bonding area; 23. Strip-shaped slit;

[0046] 3. Soluble microneedle patch; 31. Substrate; 32. Microneedles. Detailed Description of the Embodiments

[0047] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application more clearly understood, the following further details the present application in conjunction with the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0048] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0049] It should be understood that the orientation or position relationship indicated by terms such as "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0050] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0051] The following is combined with Figure 1-5 This application is described in further detail.

[0052] Reference Figure 1-Figure 3 , Example 1 of the present application discloses a method for making a gauze microcrystalline patch, comprising the following steps:

[0053] Step 1: Cut the raw gauze into a finger-pressing gauze sheet 2 according to a preset shape, apply glue on one side of the finger-pressing gauze sheet 2, and form a first bonding area 21 and a second bonding area 22 on the side of the finger-pressing gauze sheet 2;

[0054] Step 2: Cutting the raw plastic sheet into a protective film sheet 1 with a hollow hole 11 according to a preset shape;

[0055] Step 3: Bond the protective film 1 to the finger-pressure gauze sheet 2 through the first bonding area 21 until the outer contour of the protective film 1 completely covers the outer contour of the finger-pressure gauze sheet 2 and the second bonding area 22 is exposed from the hollow hole 11;

[0056] Step 4: Prepare a soluble microneedle dry sheet. The soluble microneedle dry sheet includes a substrate 31 and microneedles 32. The microneedles 32 are provided in a plurality and arranged in an array on one side of the substrate 31. The substrate 31 and the microneedles 32 are integrally formed (see Figure 4 );

[0057] Step 5: Customize a ring cutter of a preset shape, and use the ring cutter to cut the soluble microneedle dry sheet into soluble microneedle patches 3 by punching up and down, wherein the area of ​​the soluble microneedle patch 3 is smaller than the area of ​​the hollow hole 11;

[0058] Step 6: Pick up the soluble microneedle patch 3 by wearing leather gloves or using a clamp. After the soluble microneedle patch 3 passes through the hollow hole 11, the substrate 31 is bonded to the second bonding area 22 to obtain a gauze microcrystal patch.

[0059] Specifically, in step one, a first die-cutting knife is customized, wherein the outer contour of the blade of the first die-cutting knife is consistent with the outer contour of the finger-pressed gauze piece 2, and the first die-cutting knife is installed on a first die-cutting machine, the raw gauze is rolled onto a reel to form a gauze roll, the gauze roll is installed on a feeding rack of the first die-cutting machine, and the first die-cutting machine is started to automatically die-cut the raw gauze into the finger-pressed gauze piece 2 through the first die-cutting knife.

[0060] Specifically, the first bonding area 21 is an annular structure and is located at the peripheral edge of the finger pressure gauze piece 2, and the second bonding area 22 is a plurality of strip structures arranged at intervals, and all the strip structures are located in the middle of the annular structure.

[0061] In step 2, a second die-cutting knife is customized, wherein the inner and outer contours of the blade of the second die-cutting knife are consistent with the inner and outer contours of the protective film 1, and the second die-cutting knife is installed on a second die-cutting machine, the raw plastic sheet is rolled onto a reel to form a plastic sheet roll, and the plastic sheet roll is installed on a feeding rack of the second die-cutting machine, and the second die-cutting machine is started to automatically die-cut the plastic sheet into the protective film 1 through the second die-cutting knife.

[0062] The first die-cutting machine and the second die-cutting machine in the present embodiment are both fully automatic die-cutting machines commonly found on the market.

[0063] Wherein step 4 includes the following steps:

[0064] Step S41: making a PDMS microneedle mold;

[0065] Step S42: preparing a stock solution: processing the drug or skin care component into a small or medium molecular weight substance, and adding it to a sodium hyaluronate solution having a mass concentration of 8-10% according to a preset ratio, and then stirring the solution at a temperature of 38-42° C. for 1.8-2.2 hours, and then removing bubbles from the stirred liquid to obtain a stock solution;

[0066] Step S43, pretreatment of the PDMS microneedle mold: first, ultrasonically clean the PDMS microneedle mold for 15-25 minutes, then ultraviolet disinfect the PDMS microneedle mold for 35-45 minutes, and finally, plasma treat the PDMS microneedle mold;

[0067] Step S44, injecting stock solution into the mold: taking a certain amount of stock solution according to the cavity volume of the PDMS microneedle mold, and injecting it into the cavity of the PDMS microneedle mold, and flattening the stock solution in the cavity of the PDMS microneedle mold, and then removing bubbles from the stock solution in the PDMS microneedle mold;

[0068] Step S45, drying and molding: leaving the PDMS microneedle mold containing the stock solution to stand for 14-16 hours until the stock solution is dried into a sheet;

[0069] Step S46, demoulding: along the opening edge of the PDMS microneedle mold, lift the sheet-like membrane from the cavity of the PDMS microneedle mold to obtain a soluble microneedle dry sheet.

[0070] The manufacturing method of the present application has a simple and reasonable process, a relatively low production cost, and is suitable for mass industrial production;

[0071] The use process of the gauze microcrystalline patch produced by the manufacturing method of the present application is roughly as follows: the user clamps the edge of the protective film 1 with fingers, moves the product near the human skin, then peels off the protective film 1, aligns the hollow hole 11 with the pre-sticking and pleasing of the skin, presses the finger-pressure gauze sheet 2, and allows the microneedles 32 of the soluble microneedle patch 3 to penetrate the skin, after which the soluble microneedle patch 3 will dissolve, so that the medicine or skin care ingredients carried inside it will be released into the skin, and then liquid / paste (similar to essence and other substances) is applied to the outer surface of the finger-pressure gauze sheet 2, so that the liquid / paste will penetrate the finger-pressure gauze sheet 2 to contact the skin, play a role in repairing care and dissolving and absorbing the soluble microneedle patch 3, wait for a period of time until the soluble microneedle patch 3 is completely dissolved, then the finger-pressure gauze sheet 2 can be peeled off from the skin and discarded, and then the skin can be cleaned;

[0072] The gauze microcrystal patch and the soluble microneedle patch 3 produced by the manufacturing method of the present application make full use of the technical principle of transdermal drug delivery / skin care ingredients, and cooperate with the finger pressure gauze sheet 2 to apply the liquid / paste, which not only facilitates the full absorption of the medicine or skin care ingredients, but also has a simple structure, relatively low manufacturing cost, and is more convenient to operate and use, which is conducive to large-scale promotion and application; and in the process of producing, transporting, transferring and pasting the soluble microneedle patch 3 on the skin, the finger pressing operation directly contacts the finger pressure gauze sheet 2, that is, the finger does not directly contact the soluble microneedle patch 3, so even if there is sweat or water on the finger, it is not easy to cause the soluble microneedle patch 3 to dissolve prematurely, and the skin care and treatment effects are better, safer and more hygienic, and the user experience is better.

[0073] Reference Figure 3 and Figure 4 The protective film 1 has two protruding gripping parts 12 on opposite sides. When in operation, the user can clamp the gripping parts 12 with fingers, which is more stable and the product is not easy to fall off. It can also effectively avoid direct contact between the fingers and the acupressure gauze sheet 2 and the soluble microneedle patch 3, which is safer and more hygienic.

[0074] The outer contour of the protective film 1 exceeds the outer contour of the finger-pressure gauze sheet 2, and the width of the exceeding part is 1-10 mm. The protective film 1 and the finger-pressure gauze sheet 2 are designed to have the same shape, and the overall product appearance is more beautiful and coordinated, which can save more materials and relatively reduce product costs. The outer contour of the protective film 1 is larger than the outer contour of the finger-pressure gauze sheet 2. When holding the product, it is effectively prevented that the fingers accidentally touch the finger-pressure gauze sheet 2 and the soluble microneedle patch 3, which is safer and more hygienic.

[0075] The microneedle 32 is a conical structure or a multi-faceted pyramid structure. The structural design of the microneedle 32 can prevent the microneedle 32 and the substrate 31 from breaking easily, and can also ensure that the microneedle 32 can penetrate the skin smoothly.

[0076] The angle a between the microneedle 32 and the substrate 31 is between 75-105 degrees. Specifically, in this embodiment, the microneedle 32 and the substrate 31 are perpendicular to each other. The angle design of the microneedle 32 is more conducive to the microneedle 32 penetrating into the skin, and the microneedle 32 and the substrate 31 are not easy to break.

[0077] In this embodiment, the soluble microneedle patch 3 is in the shape of an isosceles trapezoid, a concave portion is provided in the middle of one side of the soluble microneedle patch 3 close to the upper bottom, and a convex portion is provided in the middle of one side of the soluble microneedle patch 3 close to the lower bottom. The soluble microneedle patch 3 designed as above can be applied to the tip of the nose and the wings of the nose.

[0078] In other embodiments, the soluble microneedle patch 3 may also be rectangular, elliptical, or oval in shape.

[0079] Please refer to Figure 5 Embodiment 2 of the present application further provides a gauze microcrystal patch, wherein a strip-shaped hole 23 is provided in the middle of the acupressure gauze sheet 2, and a plurality of the soluble microneedle patches 3 are adhered to one of the acupressure gauze sheets 2, wherein two of the soluble microneedle patches 3 are respectively located on both sides of the strip-shaped hole 23.

[0080] The main bodies of the finger-pressure gauze sheet 2 and the protective film sheet 1 are both elliptical in shape, the strip-shaped holes 23 are arranged along the long axis of the finger-pressure gauze sheet 2, and the hollow holes 11 on the protective film sheet 1 are also elliptical in shape.

[0081] The gauze microcrystal patch of the above design can be applied to the eyes or mouth. The additionally designed strip-shaped holes 23 can be just enough for the eyes or mouth to open, while the soluble microneedle patches 3 on both sides of the strip-shaped holes 23 can avoid the position where the eyes or mouth are opened.

[0082] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the application should be included in the protection scope of the present application.

Claims

1. A method for making a gauze microcrystalline patch, It is characterized in that The steps include: Step 1: cutting the raw gauze into a finger-pressing gauze sheet (2) according to a preset shape, applying glue on one side of the finger-pressing gauze sheet (2), and forming a first bonding area (21) and a second bonding area (22) on the side of the finger-pressing gauze sheet (2); Step 2: Cutting the raw plastic sheet into a protective film sheet (1) with a hollow hole (11) according to a preset shape; Step 3: Adhere the protective film (1) to the finger-pressure gauze sheet (2) through the first adhesive region (21), until the outer contour of the protective film (1) completely covers the outer contour of the finger-pressure gauze sheet (2), and the second adhesive region (22) is exposed from the hollow hole (11); Step 4: preparing a soluble microneedle dry sheet, wherein the soluble microneedle dry sheet comprises a substrate (31) and microneedles (32), wherein a plurality of microneedles (32) are arranged in an array on one side of the substrate (31), and the substrate (31) and the microneedles (32) are integrally formed; Step 5: customizing a ring cutter of a preset shape, and using the ring cutter to cut the soluble microneedle dry sheet into soluble microneedle patches (3) by punching up and down, wherein the area of ​​the soluble microneedle patch (3) is smaller than the area of ​​the hollow hole (11); Step 6: Pick up the soluble microneedle patch (3) by wearing leather gloves or using a clamp. After the soluble microneedle patch (3) passes through the hollow hole (11), the substrate (31) is bonded to the second bonding area (22) to obtain a gauze microcrystal patch.

2. The method for making the gauze microcrystalline patch according to claim 1, It is characterized in that In step one, a first die-cutting knife is customized and installed on a first die-cutting machine. The raw gauze is rolled onto a reel to form a gauze roll, and the gauze roll is installed on a feeding rack of the first die-cutting machine. The first die-cutting machine is started to automatically die-cut the raw gauze into finger-pressed gauze sheets (2) through the first die-cutting knife.

3. The method for making the gauze microcrystalline patch according to claim 1, It is characterized in that The first bonding area (21) is an annular structure and is located at the peripheral edge of the finger pressure gauze sheet (2), and the second bonding area (22) is a plurality of strip structures arranged at intervals, and all the strip structures are located in the middle of the annular structure.

4. The method for making the gauze microcrystalline patch according to claim 1, It is characterized in that In step 2, a second die-cutting knife is customized and installed on a second die-cutting machine. The raw plastic sheet is rolled onto a reel to form a plastic sheet roll, which is then installed on a feed rack of the second die-cutting machine. The second die-cutting machine is started to automatically die-cut the plastic sheet into protective film sheets (1) using the second die-cutting knife.

5. The method for making the gauze microcrystalline patch according to claim 1, It is characterized in that In step 4, the following steps are included: Step S41: making a PDMS microneedle mold; Step S42: preparing a stock solution: processing the drug or skin care component into a small or medium molecular weight substance, and adding it to a sodium hyaluronate solution having a mass concentration of 8-10% according to a preset ratio, and then stirring the solution at a temperature of 38-42° C. for 1.8-2.2 hours, and then removing bubbles from the stirred liquid to obtain a stock solution; Step S43, pretreatment of the PDMS microneedle mold: first, ultrasonically clean the PDMS microneedle mold for 15-25 minutes, then ultraviolet disinfect the PDMS microneedle mold for 35-45 minutes, and finally, plasma treat the PDMS microneedle mold; Step S44, injecting stock solution into the mold: taking a certain amount of stock solution according to the cavity volume of the PDMS microneedle mold, and injecting it into the cavity of the PDMS microneedle mold, and flattening the stock solution in the cavity of the PDMS microneedle mold, and then removing bubbles from the stock solution in the PDMS microneedle mold; Step S45, drying and molding: leaving the PDMS microneedle mold containing the stock solution to stand for 14-16 hours until the stock solution is dried into a sheet; Step S46, demoulding: along the opening edge of the PDMS microneedle mold, lift the sheet-like membrane from the cavity of the PDMS microneedle mold to obtain a soluble microneedle dry sheet.

6. A gauze microcrystalline patch produced by the production method according to any one of claims 1 to 5.

7. The gauze microcrystalline patch according to claim 6, It is characterized in that The protective film (1) is provided with gripping portions (12) protruding from opposite sides thereof.

8. The gauze microcrystalline patch according to claim 6, It is characterized in that The outer contour of the protective film (1) exceeds the outer contour of the finger pressure gauze sheet (2), and the width of the exceeding portion is 1-10 mm.

9. The gauze microcrystalline patch according to claim 6, It is characterized in that A strip-shaped hole (23) is provided in the middle of the finger-pressure gauze sheet (2), and a plurality of the soluble microneedle patches (3) are bonded to one of the finger-pressure gauze sheets (2), wherein two of the soluble microneedle patches (3) are respectively located on both sides of the strip-shaped hole (23).

10. The gauze microcrystalline patch according to claim 6, It is characterized in that The microneedle (32) is a conical structure or a polygonal pyramid structure, and the angle a between the microneedle (32) and the substrate (31) is between 75 and 105 degrees.

Images