Composition with moisturizing, soothing, oil-controlling and anti-oxidation effects, preparation method and application

Abstract

The invention discloses a composition with moisturizing, soothing, oil-controlling and anti-oxidation effects as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition comprises panthenol, polyol, sarcosine, amino acid and derivatives thereof, nanogold and the balance of water. The preparation method of the composition comprises the following steps: weighing the panthenol, the polyol, the sarcosine, the amino acid and the derivatives thereof according to the proportion, mixing, and heating in a water bath at 75-85 DEG C until all the components are uniformly mixed and dissolved to obtain a mixture. The mixture and chloroauric acid are mixed to obtain a precursor solution, the precursor solution and inert gas are injected into the microreactor through pipelines connected with the two ends of a three-way valve respectively, and a composition solution is generated under the action of plasma. Active substances generated in the plasma can also kill bacteria carried by the polyhydric alcohols, the amino acids and the derivatives of the polyhydric alcohols, the amino acids and the derivatives of the polyhydric alcohols. And the modified nanogold has better dispersity in the solution, so that the agglomeration of the nanogold is avoided, and the stability of the formula is further improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a composition with moisturizing, soothing, oil-controlling and antioxidant effects, a preparation method and application thereof. Background Art

[0002] With the increase of environmental pollution, ultraviolet radiation and life pressure, the skin is susceptible to external stimuli and oxidative damage, which leads to a series of skin problems such as dryness, sensitivity, inflammation and early aging. These problems are usually caused by impaired skin barrier function and excessive generation of free radicals. Modern skin care science research shows that the development of a composition with four functions of moisturizing, soothing, oil control and anti-oxidation is of great significance for improving skin health, enhancing barrier function and delaying aging. However, existing moisturizing and soothing compositions usually have the disadvantages of not being able to moisturize for a long time and only staying on the surface of the skin. Antioxidant ingredients such as plant polyphenols have a large molecular weight and are difficult to penetrate the stratum corneum, resulting in the disadvantage of lower than expected effects.

[0003] Panthenol is a derivative of vitamin B5. Compared with vitamin B5, panthenol is more stable and has a smaller molecular weight. It can effectively penetrate into the stratum corneum, absorb and lock in moisture, significantly improve skin hydration, and improve dryness and roughness. In addition, panthenol has a good soothing effect, can help repair damaged skin barriers, relieve inflammation and irritation, and is especially suitable for sensitive skin or after-sun repair. Because it can penetrate the hair shaft, enhance hair toughness, and reduce breakage and split ends, it is also widely used in hair care products. Sarcosine is a naturally occurring small molecule amino acid derivative that is widely distributed in human tissues and a variety of organisms. In recent years, sarcosine has attracted attention for its excellent skin care properties. In skin care products, sarcosine is often used as a moisturizing and antioxidant ingredient because of its mild and safe properties, plus it can help maintain the moisture balance of the skin, while protecting the skin by neutralizing free radicals and reducing oxidative stress reactions. In addition, sarcosine can inhibit the activity of 5α-reductase, that is, reduce the production of dihydrotestosterone, thereby reducing the amount of sebum secreted by dihydrotestosterone binding receptors, and play a role in oil control.

[0004] In addition to panthenol and sarcosine, nanogold has also received much attention in the cosmetics field in recent years. Its tiny particles are more easily absorbed by the dermis and subcutaneous tissue, which can instantly awaken dormant cells, restore cell vitality, produce more collagen to fight free radicals, and prevent skin aging. In addition, it has the functions of non-toxicity, antibacterial and antiseptic, and promoting metabolism. It can be added to cosmetics as an active ingredient to enhance its efficacy. However, the disadvantages of the traditional nanogold preparation method (time-consuming; use of chemical reducing agents (affecting the stability of the formula); easy aggregation of products and unstable batch quality, affecting its efficacy) limit its widespread use in the cosmetics field.

[0005] Microchannel coupled plasma has great advantages in preparing nanomaterials. (1) The precise control capability of the microchannel reactor structure can effectively regulate the size and morphology of precious metal nanoparticles. Under the action of plasma, metal salt precursors are reduced to precious metal nanoparticles. Through microchannel design, the reaction conditions (such as temperature, pressure, and gas flow) can be precisely controlled to obtain nanomaterials with uniform size and narrow distribution, thereby improving the stability of the formulation. (2) The plasma environment can produce highly active particles (such as electrons, ions, free radicals, etc.), which can quickly reduce precious metal salts to form precious metal nanoparticles. The role of the microchannel is to promote the full contact between these highly active particles and the precursors, improve the reduction efficiency, and reduce the amount of reducing agent used in traditional chemical reduction reactions; while reducing the metal salts, the highly active particles will also sterilize the precursors, improving the safety of the product; the nanogold particles generated by plasma are negatively charged, repel each other, and reduce agglomeration. (3) Microchannel coupled plasma technology can avoid organic solvents or other toxic reducing agents commonly used in traditional chemical synthesis methods, providing a more environmentally friendly synthesis route. This method achieves the synthesis of precious metal nanomaterials through physical means, which can significantly reduce the generation of environmental pollutants.

[0006] The inventors of the present invention use panthenol and sarcosine to compound suitable raw materials to obtain a mixture with moisturizing, soothing, oil-controlling and antioxidant effects, and use a microchannel device to plasma-treat the mixture and chloroauric acid to obtain a composition. Experimental verification shows that the synergistic effect between the components of the composition enables it to have a more excellent moisturizing, soothing and oil-controlling effect, and is suitable for skin and hair products. After adding nano-gold particles and performing surface modification, its antioxidant properties are enhanced. Summary of the invention

[0007] Based on the deficiencies in the prior art, the present invention provides a composition with moisturizing, soothing, oil-controlling and antioxidant effects, a preparation method and application, which can solve the problems of moisturizing, soothing and oil-controlling products on the market that the moisturizing effect is not long-lasting, the soothing and oil-controlling effect is poor, and it is difficult to enter the stratum corneum to repair the skin.

[0008] The technical solution of the present invention:

[0009] A composition with moisturizing, soothing, oil-controlling and antioxidant effects comprises, by mass percentage, 0.20% to 2.25% panthenol, 0.50% to 2.00% polyol, 0.10% to 2.25% sarcosine, 0.50% to 2.00% amino acids and their derivatives, 0.05% to 0.20% nanogold, and the remainder is water.

[0010] In a preferred embodiment, the polyol in the composition is one or a mixture of two or more of propylene glycol, glycerol, pentanediol, octanediol and nonanediol.

[0011] In a preferred embodiment, the amino acids and their derivatives in the composition are one or a mixture of two or more of glycine, tyrosine, tryptophan, arginine and aspartic acid.

[0012] On the one hand, the composition with moisturizing and soothing effects provided by the present invention is applied to hair products, which can keep hair moisturized for a long time, increase hair gloss, and enhance hair mechanical properties.

[0013] On the other hand, the composition with moisturizing, soothing and oil-controlling effects provided by the present invention is used in skin products to moisturize and improve the barrier, soothe, control oil and promote repair.

[0014] A method for preparing a composition having moisturizing, soothing and antioxidant effects, comprising the following steps:

[0015] Step 1: Weigh panthenol, polyol, sarcosine, amino acids and their derivatives according to proportion, mix them, and heat them in a water bath until all the components are mixed and dissolved to obtain a mixture.

[0016] Step 2: Mix the mixture with chloroauric acid to obtain a precursor solution. The precursor solution and the inert gas are respectively injected into the microreactor through pipes connected to both ends of the three-way valve to generate a composite solution under the action of plasma.

[0017] In one preferred embodiment, the plasma microreactor used in step 2 includes conductive materials disposed on the front and back surfaces of the microreactor, and the conductive materials on the front and back surfaces are respectively connected to an electrode of an AC power source and a ground electrode.

[0018] The microreactor, the AC power supply and the voltage-stabilizing impedance form a closed loop, thereby generating plasma in the microchannel of the microreactor.

[0019] In one preferred embodiment, the water bath heating temperature is 75-85°C.

[0020] In a preferred embodiment, the power of the plasma equipment is controlled at 2W-5W.

[0021] In one preferred embodiment, the flow rate of the precursor solution is controlled to be 0.1 to 0.5 mL / min.

[0022] In a preferred embodiment, the inert gas is argon and helium, or a mixture of the two.

[0023] In one preferred embodiment, the gas flow rate is 30 sccm to 50 sccm.

[0024] The preparation method of the present invention is simple, easy to operate, and green and environmentally friendly. When the composition is used in hair products, it can moisturize and lock in moisture, improve hair quality, reduce split ends, and improve hair toughness. When the composition is used in skin products, it can moisturize and improve the barrier, soothe, promote repair, control oil, and resist oxidation. The nanogold produced by plasma is safer than traditional chemical methods. The active substances generated in plasma can also disinfect bacteria carried by polyols, amino acids and their derivatives themselves. In addition, the modified nanogold has better dispersibility in the solution, avoids the agglomeration of nanogold, and further improves the stability of the formula. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 The thermogravimetric diagrams of hair according to different embodiments.

[0026] Figure 2 These are the hair pictures of the blank group, Example 5, Example 6, and Example 7.

[0027] Figure 3 The VISIA facial red area pictures are shown before and after two weeks of use of Example 5.

[0028] Figure 4 These are the plasma electrochemical characterization diagrams of Example 1, where (a) is a voltage-charge diagram and (b) is a Lissajous diagram.

[0029] Figure 5 This is the OES graph generated by the plasma in Example 1.

[0030] Figure 6 Example 1 Nanogold TEM (TEM of the composition) DETAILED DESCRIPTION

[0031] The present invention is further described in detail below with reference to the examples, but the embodiments of the present invention are not limited thereto.

[0032] The plasma microreactor comprises conductive materials arranged on the front and back surfaces of the microreactor, and the conductive materials on the front and back surfaces are respectively connected to the electrodes of the AC power supply and the ground electrode. The microreactor, the AC power supply and the voltage-stabilizing impedance form a closed loop, thereby generating plasma in the microchannel of the microreactor.

[0033] Example 1

[0034] Based on the total mass of the composition being 100%, 0.50% panthenol, 0.50% glycerol, 0.50% sarcosine, 0.50% aspartic acid, and 48.00% water were weighed in proportion, mixed, and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve at 0.2mL / min by a syringe pump, and the other end of the three-way valve was connected to 30sccm of argon gas. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on and the power was adjusted to 2W. After the plasma was applied, a composition was obtained.

[0035] Example 2

[0036] Based on the total mass of the composition being 100%, 0.50% panthenol, 0.20% pentanediol, 0.20% octanediol, 1.00% arginine, 0.10% sarcosine, 1.00% glycine, and 47.00% water were weighed in proportion, mixed, and placed in a 75°C water bath for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a 1:1 ratio, and pushed into a three-way valve at 0.2mL / min by a syringe pump, and the other end of the three-way valve was connected to 40sccm of helium. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on, and the power was adjusted to 2W. After the plasma was applied, a composition was obtained.

[0037] Example 3

[0038] Based on the total mass of the composition being 100%, 0.20% of panthenol, 0.30% of propylene glycol, 0.90% of glycerol, 0.70% of octanediol, 0.10% of nonanediol, 0.50% of sarcosine, 0.30% of glycine, and 47.00% of water were weighed and mixed and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve at 0.1mL / min by a syringe pump, and the other end of the three-way valve was connected to 50sccm of argon gas. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on and the power was adjusted to 4W. After the plasma was applied, a composition was obtained.

[0039] Example 4

[0040] Based on the total mass of the composition being 100%, 1.00% panthenol, 0.40% glycerol, 0.60% octanediol, 0.60% pentanediol, 1.00% sarcosine, 0.20% aspartic acid, 0.60% tyrosine, 0.60% tryptophan, and 45.00% water were weighed and mixed and placed in a water bath at 85°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve at 0.2mL / min by a syringe pump, and the other end of the three-way valve was connected to 30sccm of argon gas. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on and the power was adjusted to 5W. After the plasma was applied, a composition was obtained.

[0041] Example 5

[0042] According to the total mass of the composition as 100%, 1.50% of panthenol, 0.40% of propylene glycol, 0.30% of glycerol, 0.60% of pentanediol, 0.40% of octanediol, 1.50% of sarcosine, 0.50% of glycine, 0.20% of aspartic acid, 0.60% of tryptophan, and 44.00% of water were weighed and mixed and placed in a 75°C water bath for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve by a syringe pump at 0.2mL / min. The other end of the three-way valve was connected to 30sccm of argon gas. After mixing, they were injected into a microchannel reactor together, the power was adjusted to 3W, and the plasma equipment was turned on. After the plasma was applied, a composition was obtained.

[0043] Example 6

[0044] According to the total mass of the composition as 100%, 1.00% panthenol, 0.30% propylene glycol, 0.20% glycerol, 0.30% octanediol, 1.00% pentanediol, 2.00% sarcosine, 0.20% aspartic acid, 0.40% arginine, 0.60% tyrosine, and 44.00% water were weighed and mixed and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve by a syringe pump at 0.2mL / min, and the other end of the three-way valve was connected to 30sccm of argon gas, and after mixing, they were injected into a microchannel reactor together, the power was adjusted to 2W, and the plasma equipment was turned on. After the plasma was applied, a composition was obtained.

[0045] Example 7

[0046] Based on the total mass of the composition being 100%, 2.00% panthenol, 1.00% propylene glycol, 0.40% pentanediol, 0.50% nonanediol, 1.00% sarcosine, 0.50% aspartic acid, 0.30% arginine, 0.30% glycine, and 44.00% water were weighed and mixed and placed in a water bath at 85°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve at 0.2mL / min by a syringe pump, and the other end of the three-way valve was connected to 30sccm of argon gas. After mixing, they were injected into a microchannel reactor together, the power was adjusted to 3W, and the plasma equipment was turned on. After the plasma was applied, a composition was obtained.

[0047] Example 8

[0048] Based on the total mass of the composition being 100%, 2.25% of panthenol, 0.50% of glycerol, 0.60% of octanediol, 0.10% of pentanediol, 0.50% of nonanediol, 0.75% of sarcosine, 1.00% of aspartic acid, 0.30% of glycine, and 44.00% of water were weighed and mixed and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve at 0.2mL / min by a syringe pump, and the other end of the three-way valve was connected to a 30sccm mixed gas of argon and helium, and after mixing, they were injected into a microchannel reactor together, the power was adjusted to 4W, and the plasma equipment was turned on. After the action of plasma, a composition was obtained.

[0049] Example 9

[0050] According to the total mass of the composition as 100%, 0.75% of panthenol, 0.30% of propylene glycol, 0.20% of glycerol, 0.60% of octanediol, 0.10% of pentanediol, 0.50% of nonanediol, 2.25% of sarcosine, 1.00% of aspartic acid, 0.30% of glycine, and 44.00% of water were weighed and mixed and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve by a syringe pump at 0.5mL / min, and the other end of the three-way valve was connected to 30sccm of argon gas. After mixing, they were injected into a microchannel reactor together, the power was adjusted to 3W, and the plasma equipment was turned on. After the plasma was applied, a composition was obtained.

[0051] Example 10

[0052] According to the total mass of the composition as 100%, 1.80% of panthenol, 0.30% of glycerol, 0.50% of octanediol, 0.40% of pentanediol, 0.50% of nonanediol, 1.20% of sarcosine, 0.30% of aspartic acid, 0.20% of arginine, 0.50% of tryptophan, 0.30% of glycine, and 44.00% of water were weighed and mixed and placed in a water bath at 85°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve by a syringe pump at 0.2mL / min. The other end of the three-way valve was connected to 30sccm of helium. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on and the power was adjusted to 2W. After the plasma was applied, a composition was obtained.

[0053] Embodiment 11

[0054] According to the total mass of the composition as 100%, 1.20% of panthenol, 0.20% of propylene glycol, 0.20% of octanediol, 0.50% of pentanediol, 0.80% of nonanediol, 1.80% of sarcosine, 0.40% of aspartic acid, 0.10% of arginine, 0.30% of tyrosine, 0.50% of glycine, and 44.00% of water were weighed and mixed and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 1:1, and pushed into a three-way valve by a syringe pump at 0.3mL / min. The other end of the three-way valve was connected to a 30sccm argon-helium mixed gas, and after mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on, and the power was adjusted to 3W. After the action of plasma, a composition was obtained.

[0055] Example 12

[0056] Based on the total mass of the composition being 100%, 0.50% panthenol, 0.60% glycerol, 0.60% pentanediol, 0.60% nonanediol, 0.50% sarcosine, 0.20% aspartic acid, and 72.00% water were weighed and mixed in proportion and placed in a water bath at 80°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 3:1, and pushed into a three-way valve by a syringe pump at 0.2mL / min. The other end of the three-way valve was connected to a 45sccm argon-helium mixed gas. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on, and the power was adjusted to 4W. After the plasma was applied, a composition was obtained.

[0057] Example 13

[0058] Based on the total mass of the composition being 100%, 0.50% panthenol, 0.30% glycerol, 0.60% pentanediol, 0.60% nonanediol, 0.50% sarcosine, 0.50% aspartic acid, and 72.00% water were weighed in proportion, mixed, and placed in a water bath at 85°C for 10 minutes until all components were mixed and dissolved to obtain a mixture. The mixture was mixed with 2mM chloroauric acid in a ratio of 3:1, and pushed into a three-way valve at 0.2mL / min by a syringe pump, and the other end of the three-way valve was connected to 30sccm of argon gas. After mixing, they were injected into a microchannel reactor together, and the plasma equipment was turned on, and the power was adjusted to 4W. After the action of plasma, a composition was obtained.

[0059] Comparative Example 1 (Compared with Example 1)

[0060] Based on the total mass of the composition being 100%, 0.50% of panthenol, 0.50% of glycerol, 0.50% of sarcosine, 0.50% of aspartic acid and 98.00% of water were weighed in proportion, mixed and heated in a water bath at 80° C. for 10 min until all components were mixed and dissolved, to obtain a composition.

[0061] Comparative Example 2 (Compared with Example 4)

[0062] Based on the total mass of the composition being 100%, 1.00% of panthenol, 0.40% of glycerol, 0.60% of caprylyl glycol, 0.60% of pentylene glycol, 1.00% of sarcosine, 0.20% of aspartic acid, 0.60% of tyrosine, 0.60% of tryptophan and 95.00% of water are weighed in proportion, mixed, and heated in a water bath at 80° C. for 10 min until all components are mixed and dissolved, to obtain a composition.

[0063] Comparative Example 3 (Compared with Example 5)

[0064] Based on the total mass of the composition being 100%, 1.50% of panthenol, 0.40% of propylene glycol, 0.30% of glycerol, 0.60% of pentanediol, 0.40% of caprylyl glycol, 1.50% of sarcosine, 0.50% of glycine, 0.20% of aspartic acid, 0.60% of tryptophan and 94.00% of water are weighed in proportion, mixed, and heated in a water bath at 80° C. for 10 min until all components are mixed and dissolved, to obtain a composition.

[0065] Comparative Example 4

[0066] According to the total mass of the composition as 100%, 0.50% panthenol, 0.50% glycerol, 0.50% sarcosine, 0.50% aspartic acid, and 48.00% water are weighed in proportion, mixed, and placed in an 80°C water bath for 10 minutes until all components are mixed and dissolved to obtain a mixture. 1.0 mL of 5 mmol / L chloroauric acid solution is measured with a pipette and added to a round-bottom flask containing 50 ml of distilled water, heated and stirred at 90°C until boiling, and then 4.0 mL of 38.8 mmol / L sodium citrate solution is added at one time, and stirring and heating are continued until the reaction mixture presents a stable wine red color, stirring and heating are stopped, and the nano gold solution is naturally cooled. The nano gold solution and the mixture solution are mixed in equal proportions, stirred evenly, and a composition is obtained.

[0067] Comparative Example 5

[0068] According to the total mass of the composition as 100%, 0.50% of panthenol, 0.50% of glycerol, 0.50% of sarcosine, 0.50% of aspartic acid, and 48.00% of water are weighed in proportion, mixed, and placed in a water bath at 80°C for 10 minutes to mix and dissolve all the components to obtain a mixture. 2mM chloroauric acid is pushed into a three-way valve by a syringe pump at 0.2mL / min, and the other end of the three-way valve is connected to 30sccm of argon gas. After mixing, they are injected into a microchannel reactor together, and a plasma device is turned on, and the power is adjusted to 2W. After the action of plasma, a nano gold solution is obtained. The nano gold solution and the mixture are mixed in equal proportions, and stirred evenly to obtain a composition.

[0069] like Figure 6 As shown, the generated nano-gold composite particles have uniform size and are not easy to agglomerate.

[0070] Plasma photoelectrochemical testing:

[0071] The power generated by the plasma is obtained by calculation as follows: first, the waveforms of charge (Q) and voltage (V) are recorded using a Tektronix-TBS1102 digital oscilloscope, and then the Lissajous curve is drawn based on the obtained data. The power P is calculated according to the following formula:

[0072]

[0073] Where P represents the plasma power, Q m is the instantaneous capacitor charge, V a is the instantaneous voltage and T is the AC period.

[0074] The OES spectrum was obtained using a fiber optic spectrometer (Shanghai Chenxu Instrument Equipment Co., Ltd., model ER4000-EX).

[0075] like Figure 3As shown, the plasma power is 2W.

[0076] like Figure 4 As shown in the figure, a strong transition peak (4p→4s) belonging to the Ar atom can be observed in the wavelength range of 690 to 850 nm. In addition, several peaks with lower intensity were observed, which were respectively attributed to the OH band (307 to 318 nm), atomic O (777 nm) and atomic H of the Balmer series (Hα: 656 nm), which can be inferred that water molecules dissociate under the action of plasma.

[0077] Hair moisturizing test:

[0078] Test method: Wet a certain amount of hair with (37.0±1.0)℃ water, apply a specified amount of product on the hair, and squeeze and wash along the direction of the hair to the end to ensure that it is not messy and can be evenly sampled for 1 minute, then rinse with (37.0±1.0)℃, 4L / min water flow for 30s, and squeeze the water on the hair from top to bottom every 5s. Then cut the prepared hair into pieces, weigh 8-10mg of hair in a crucible, heat it up and record the weight of the hair. (Temperature range: 50-200℃, heating rate: 15℃ / min, nitrogen flow rate: 50mL / min).

[0079] like Figure 1 As shown, Example 7 has a better moisturizing effect than the other examples because the ratio of added panthenol is the best.

[0080] like Figure 2 As shown, after using the moisturizing composition, the hair of the example was smoother and the frizziness was reduced compared with the blank group (hair washed with water and without any substance applied).

[0081] Mechanical properties test:

[0082] Test method: Wet a certain amount of hair with (37.0±1.0)℃ water, apply a specified amount of product on the hair, squeeze and wash the hair towards the end to ensure that it is not messy and can be evenly sampled for 1 minute, then rinse with (37.0±1.0)℃, 4L / min water for 30 seconds, clamp the water on the hair from top to bottom every 5 seconds, and let it dry naturally. Then use an SN-1200W high-definition camera to measure the diameter of the hair. The specific method is to take the average of the diameters at 3 positions in the middle section. Then take 20 hairs with a diameter difference of 10μm in the hair bundle and use a fiber strength tester to perform a single fiber strength test. The tensile strength of the control group (only using simple shampoo) and each sample group is calculated and compared using the following formula:

[0083] σ=F b / S 0

[0084] Where σ is the tensile strength, F b is the maximum force that the sample withstands when it is broken, S 0 is the original cross-sectional area of ​​the specimen.

[0085] In addition, the elastic modulus of the hair of the control group (using only simple shampoo) and each sample group can be calculated and compared by the Hookean segment curve and the following formula:

[0086] E=FL / SdL

[0087] Where F is the breaking strength, S is the cross-sectional area of ​​the hair, dL is the elongation of the hair, and L is the length of the hair being tested.

[0088] Table 1: Mechanical properties test results

[0089]

[0090] From the test results, Examples 1-3 are better than the blank group (hair washed with water and not coated with any substance), indicating that the elasticity and toughness of the hair can be improved after washing the hair with the composition, and the tensile properties of the hair can be effectively improved. The elastic modulus and tensile strength of Example 1 were improved by 23.49% and 23.65%, respectively, which is better than Example 2 and Example 3, indicating that the compounding of panthenol and sarcosine in equal proportions can further enhance the hair quality.

[0091] The present invention is applied to skin tests as follows:

[0092] Skin moisturizing test:

[0093] Test environment: temperature 22-23℃, relative humidity 45%-55%.

[0094] Test method: 30 volunteers with sensitive skin were selected for the test, aged 25±1.5 years old. The subjects used a multifunctional skin tester (CK, Germany) to test skin moisture and transepidermal water loss (TEWL) before and 6 hours after using the product. The specific process is: the volunteers first washed their arms and hands, and after drying, drew 3 1cm×1cm square boxes on the inner side of the left and right arms as the measurement area, with a 1cm interval between each box. After sitting in a constant temperature and humidity chamber for 30 minutes, the skin moisture content and transepidermal water loss of the corresponding area were measured, and it was used as the basic value; then 6 drops of test sample were dropped in each area, and after a period of time, the skin moisture content and transepidermal water loss of each area were measured using the same test method, and recorded as the experimental value (the subjects could not leave the constant temperature and humidity chamber during the entire test process). The change rate of skin moisture and transepidermal water loss is expressed by (experimental value-basic value) / basic value*100%.

[0095] Skin oil control test:

[0096] Test environment: temperature 22-23℃, relative humidity 45%-55%.

[0097] Test method: 30 volunteers with sensitive skin were selected for the test, aged 25±1.5 years old. The subjects used a multifunctional skin tester (CK, Germany) to control oil before using the product and 6 hours after use. The subjects washed their faces and sat in a constant temperature and humidity chamber for 30 minutes before measuring the oil content in the corresponding area, which was recorded as the basic value. Apply an appropriate amount of sample on both cheeks, and after a period of time, use the same test method to measure the oil content in the same area, which is recorded as the experimental value (the subjects cannot leave the constant temperature and humidity chamber during the entire test process). The oil removal rate is expressed as (basic value-experimental value) / basic value*100%.

[0098] Skin soothing test:

[0099] Test environment: temperature is 22-23℃, relative humidity is 45%-55%.

[0100] Test method: The subject washes the inside of both arms, dries them and draws a 2cm×2cm square on the inside of the left and right arms respectively. Sit quietly in a constant temperature and humidity chamber for 30 minutes. Soak a test paper with a radius of 1cm in a 3% mass fraction lactic acid solution. After a period of time, take out the test paper and stick it in the box. After 15 minutes, remove the test paper and measure the blood perfusion of the test area, recorded as A. Then immediately apply the sample and measure the blood perfusion (PU) 30s after applying the sample, recorded as B. The size of the (BA) / A value can reflect the strength of the immediate soothing ability. The smaller the value, the better the soothing effect of the composition.

[0101] Table 2: Skin moisturizing, oil control and soothing results

[0102]

[0103]

[0104] It can be concluded from Table 2 that the water content of the composition after equal proportion compounding increases by more than 10%, the reduction of transepidermal water loss and oil clearance rate also exceed 10%, and the blood perfusion of the stimulated skin is reduced by more than 15%, and the effect is positively correlated with the concentration. Compared with Comparative Examples 1-3, Example 1, Example 4, and Example 5 show that the addition of nanogold does not change the various effects significantly. The comparison of Examples 1-3 and Examples 5-7 shows that different amounts of panthenol and sarcosine added will have different effects. In terms of moisturizing and immediate soothing, the effect of panthenol is better than sarcosine; in terms of oil removal, the effect of sarcosine is better than panthenol. In general, the compound composition has good moisturizing, oil-controlling and soothing abilities.

[0105] Inflammation relief test:

[0106] Test environment: temperature 22-23℃, relative humidity 45%-55%.

[0107] Test method: 30 volunteers were selected for the test. They washed their faces with clean water and dried them, then sat in a constant temperature and humidity chamber for 30 minutes. After the face stabilized, the VISIA skin tester (Canfield, USA) was used to measure the facial red area and recorded it. The same method was used to measure the facial red area 1 week and 2 weeks after using the sample. The anti-inflammatory ability can be compared based on the rate of change of the red area.

[0108] Table 3: Facial red zone change rate

[0109]

[0110]

[0111] In terms of long-term soothing, compared with comparative examples 1-3, the change rate of facial red area after adding nanogold in Example 1, Example 4, and Example 5 is not much changed. Comparison between Example 1, Example 4, and Example 5 shows that the soothing effect of the compounded composition in terms of long-term soothing is positively correlated with the concentration of panthenol and sarcosine added.

[0112] like Figure 3 As shown, after using Example 5 for two weeks, the facial red areas were greatly reduced.

[0113] Antibacterial test:

[0114] Test method: According to the antibacterial ring method of QB / T2738-2012 "Evaluation method for antibacterial and antibacterial effects of daily chemical products", the antibacterial effects of each embodiment and comparative example were tested, and the antibacterial effect was evaluated by the antibacterial ring diameter. The larger the antibacterial ring diameter, the better the antibacterial effect. If the antibacterial ring diameter is greater than 7mm, it is judged to have an antibacterial effect.

[0115] Table 4: Antibacterial performance

[0116] Test products Diameter of antibacterial ring (mm) Example 1 17.74 Example 12 17.23 Comparative Example 1 2.45 Comparative Example 4 13.97 Comparative Example 5 16.43

[0117] In terms of antibacterial effect, Comparative Example 1 does not add nano gold and does not have the corresponding antibacterial effect. The comparison between Example 1, Comparative Example 4 and Comparative Example 5 shows that Example 1 has the best antibacterial effect. The possible reason is that Comparative Example 4 uses traditional chemical methods to prepare nano gold, which has the possibility of introducing new bacteria. Example 1 uses plasma to sterilize and disinfect chloroauric acid and the mixture, and the effect is also better than Comparative Example 5 (only acting on chloroauric acid). Example 1 is compared with Example 12 to show that a good antibacterial effect can be achieved at a lower nano gold concentration.

[0118] Antioxidant Test:

[0119] Test methods: ferric reducing ability assay (FRAP), hydroxyl radical scavenging ability test, DPPH free radical scavenging performance test.

[0120] Iron reducing ability determination method: Take 1.0mL of the sample solution to be tested, add 2.5mL of phosphate buffer solution and 2.5mL of 1% potassium ferrocyanide solution in sequence, mix well and incubate in a constant temperature water bath at 50℃ for 30min, then add 2.5mL of 10% trichloroacetic acid solution to the mixture, mix well and centrifuge at 4000r / min for 10min, take 5mL of the upper solution after centrifugation and mix well with 2.5mL of distilled water, continue to add 0.5mL of 1% ferric chloride solution, mix well and let stand for 10min, measure the absorbance at a wavelength of 700nm, the greater the absorbance, the stronger the oxidation ability of the sample.

[0121] Hydroxyl radical scavenging ability test: 0.5 mL of ferrous sulfate solution (1.5 mmol / L) was mixed with 0.35 mL of hydrogen peroxide (6 mmol / L), and then 0.15 mL of sodium salicylate solution (20 mmol / L) and 1.0 sample solution were added to the mixture. The mixture was incubated in a 37°C water bath for 1 h, and the absorbance of the hydroxylated salicylate complex was measured at 562 nm, which was recorded as A. 1 Instead of adding sodium salicylate, add an equal amount of deionized water and record the absorbance as A 2 . Do not add sample, add an equal amount of deionized water instead, and record the absorbance as A 3 The hydroxyl radical scavenging rate is (A 1 -A 2 ) / (A 3 -A 2 )*100%

[0122] DPPH free radical scavenging performance test: 2 mL of sample solution was mixed with 2 mL of ethanol-DPPH solution, incubated at 25°C in the dark for 30 min, and the absorbance value was measured at 517 nm, which was recorded as A 1 The sample was replaced with distilled water as a control and the absorbance A was measured. 2 DPPH free radical scavenging performance is (A 2 -A 1 ) / A 2 *100.

[0123] Table 5: Antioxidant capacity

[0124]

[0125] By comparing Example 1, Example 4, and Example 5 with Comparative Examples 1-3, it is shown that the antioxidant performance of the modified nano-gold generated by adding chloroauric acid is greatly improved. Example 1, Comparative Example 1, Comparative Example 4, and Comparative Example 5 show that the combination of pure nano-gold particles and the mixture has no significant effect on antioxidant properties.

Claims

1. A composition with moisturizing, soothing, oil-controlling and antioxidant effects, characterized in that: Calculated by mass percentage, it includes: 0.2% to 2.25% of panthenol, 0.5% to 2% of polyol, 0.1% to 2.25% of sarcosine, 0.5% to 2% of amino acids and their derivatives, 0.05% to 0.2% of nano gold, and the rest is water.

2. A composition with moisturizing, soothing, oil-controlling and antioxidant effects according to claim 1, characterized in that: The polyol in the composition is one or a mixture of two or more of propylene glycol, glycerol, pentanediol, octanediol and nonanediol.

3. A composition with moisturizing, soothing, oil-controlling and antioxidant effects according to claim 1, characterized in that: The amino acids and their derivatives in the composition are one or a mixture of two or more of glycine, tyrosine, tryptophan, arginine and aspartic acid.

4. A method for preparing a composition having moisturizing, soothing, oil-controlling and antioxidant effects as claimed in any one of claims 1 to 3, characterized in that: Here are the steps: Step 1, weighing panthenol, polyol, sarcosine, amino acids and their derivatives according to proportion, mixing them, and heating them in a water bath until all the components are mixed and dissolved to obtain a mixture; Step 2: Mix the mixture with chloroauric acid to obtain a precursor solution. The precursor solution and the inert gas are respectively injected into the microreactor through pipes connected to both ends of the three-way valve to generate a composite solution under the action of plasma.

5. The method for preparing a composition having moisturizing, soothing, oil-controlling and antioxidant effects according to claim 4, characterized in that: The plasma microreactor used in step 2 includes conductive materials arranged on the front and back surfaces of the microreactor, and the conductive materials on the front and back surfaces are respectively connected to the electrodes of the AC power supply and the ground electrode.

6. The method for preparing a composition having moisturizing, soothing, oil-controlling and antioxidant effects according to claim 5, characterized in that: The microreactor, the AC power supply and the voltage-stabilizing impedance form a closed loop, thereby generating plasma in the microchannel of the microreactor.

7. The method for preparing a composition having moisturizing, soothing, oil-controlling and antioxidant effects according to claim 4, characterized in that: The water bath heating temperature is 75-85° C.; the plasma equipment power is controlled at 2W-5W; and the flow rate of the precursor solution is controlled at 0.1-0.5 mL / min.

8. The method for preparing a composition having moisturizing, soothing, oil-controlling and antioxidant effects according to claim 4, characterized in that: The inert gas is argon and helium or a mixture of the two; the flow rate of the gas is 30 sccm to 50 sccm.

9. Use of a composition having moisturizing, soothing, oil-controlling and antioxidant effects as claimed in any one of claims 1 to 3, or a composition having moisturizing, soothing, oil-controlling and antioxidant effects obtained by the preparation method as claimed in any one of claims 4 to 8, characterized in that: When used in hair products, it can keep hair moisturized for a long time, increase hair gloss, and improve hair mechanical properties.

10. Use of a composition having moisturizing, soothing, oil-controlling and antioxidant effects as claimed in any one of claims 1 to 3, or a composition having moisturizing, soothing, oil-controlling and antioxidant effects obtained by the preparation method as claimed in any one of claims 4 to 8, characterized in that: Applied in skin products, it can moisturize and improve the skin barrier, soothe, control oil, and promote repair.

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