Processing technology for improving stability of rhizoma atractylodis lanceae

Abstract

The invention belongs to the technical field of rhizoma atractylodis lanceae, and particularly relates to a processing technology for improving the stability of rhizoma atractylodis lanceae. The method comprises the following steps: softening rhizoma atractylodis lanceae, bumping, cleaning, slicing, drying for the first time, inhibiting frosting, and drying for the second time to obtain a finished product. In the step of atractylodes lancea softening, fresh atractylodes lancea is put into a self-made softening agent to be soaked, and raw materials of the self-made softening agent comprise at least one of organic acid, cellulase and tea polyphenol. The blooming inhibition treatment is to soak the dried atractylodes lancea in a blooming inhibitor, and the raw materials of the blooming inhibitor comprise at least one of a perilla frutescens extract, a cactus extract and sodium alginate. The rhizoma atractylodis lanceae not prone to blooming is successfully prepared, the storage stability of the rhizoma atractylodis lanceae is improved, resource waste caused by mixing of the rhizoma atractylodis lanceae with mildew during use is avoided, and the medication safety of the rhizoma atractylodis lanceae is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of Atractylodes macrocephala, and in particular relates to a processing technique for improving the stability of Atractylodes macrocephala. Background Art

[0002] Atractylodes is the dried rhizome of Atractylodes macrocephala or Atractylodes macrocephala of the Asteraceae family. It has the functions of drying dampness and strengthening the spleen, dispelling wind and cold, and improving eyesight, and is widely used in clinical practice. Ye Tianshi and Xue Shengbai of the Wumen School of Medicine were good at using Atractylodes macrocephala in the treatment of damp-heat febrile diseases, and their prescriptions were recorded in "Clinical Guide Medical Cases", "Damp-heat Diseases" and "Saoye Village Medical Cases". Regarding Atractylodes macrocephala and Atractylodes macrocephala, ancient books record that "Atractylodes macrocephala is better than Atractylodes macrocephala in terms of medicinal material quality, with thin shape and firm texture, and red spots inside", and the modern monograph "Contemporary Medicinal Plant Dictionary" states that "Atractylodes macrocephala is better than Atractylodes macrocephala in terms of medicinal material quality".

[0003] Atractylodes is firm and easy to break, with many orange-yellow or brown-red oil chambers. If exposed for a long time, white hair-like crystals can be precipitated, commonly known as "frost". It has a unique aroma and tastes slightly sweet, spicy and bitter.

[0004] However, many people tend to confuse the "frost" of Atractylodes lancea with the mildew of Atractylodes lancea. When Atractylodes lancea is mildewed, the medicinal pieces feel sticky and wet when rubbed, the texture becomes soft, the color becomes darker or changes due to the degree of mildew, the smell is slightly fragrant, and even has a musty smell, and the taste is bitter. The moldy hair is white, yellow-white or yellow-green, which is related to the degree of mildew. Atractylodes lancea can frost in all seasons and can still be used for medicinal purposes. Atractylodes lancea mildews mostly in the summer during the mildewy rainy season. It often molds and deteriorates due to improper storage and grows hair, and cannot be used for medicinal purposes.

[0005] In order to avoid confusion between frosting and mildew, the present application attempts to prepare Atractylodes lancea that is not prone to frosting, improve the storage stability of Atractylodes lancea, avoid confusion with mildew during use and cause waste of resources, and improve the safety of Atractylodes lancea. Summary of the invention

[0006] The purpose of the present invention is to provide a processing technology for improving the stability of Atractylodes lancea. The present invention successfully prepares Atractylodes lancea that is not easy to frost, improves the storage stability of Atractylodes lancea, avoids confusion with mildew during use and causes waste of resources, and improves the safety of Atractylodes lancea.

[0007] In order to achieve the above-mentioned object and other related objects, the present invention provides the following technical solutions: In a first aspect, a processing process for improving the stability of Atractylodes macrocephala is provided, comprising the following steps: The Atractylodes lancea is softened, peeled, cleaned, sliced, dried for the first time, subjected to a frosting prevention treatment, and dried for the second time to a finished product.

[0008] Optionally, the Atractylodes lancea is softened by soaking fresh Atractylodes lancea in a homemade softener, wherein the raw materials of the homemade softener include at least one of organic acid, cellulase and tea polyphenols.

[0009] Optionally, the organic acid includes at least one of malic acid and citric acid.

[0010] Optionally, the homemade softener is obtained by dissolving its raw materials in water, and the mass ratio of the raw materials to water is 0.2~10:1000.

[0011] Optionally, the blooming inhibition treatment is to soak the dried Atractylodes lancea in a blooming inhibitor, wherein the raw material of the blooming inhibitor includes at least one of Perilla extract, cactus extract, and sodium alginate.

[0012] Optionally, the bloom inhibitor is obtained by dissolving its raw materials in water, and the mass ratio of the raw materials to water is 0.5~10:1000.

[0013] Optionally, during the frosting inhibition treatment, the solid-to-liquid ratio of the dried Atractylodes lancea and the frosting inhibitor is 1:1-8.

[0014] Optionally, the bloom inhibitor is prepared by adding perilla extract and / or cactus extract into water, stirring evenly, and then adding sodium alginate, stirring until completely dissolved, to obtain the bloom inhibitor.

[0015] Optionally, the first drying is to dry the sliced ​​Atractylodes lancea to a moisture content of 40% to 50%, and the first drying temperature is 35 to 80°C.

[0016] Optionally, the second drying is to dry the Atractylodes lancea after the frost inhibition treatment to a moisture content of ≤11%, the temperature of the second drying is 35~60℃, and the vacuum degree is -0.08~-0.1 MPa.

[0017] In the second aspect, a kind of Wumen medical school's characteristic Atractylodes macrocephala prepared by the aforementioned process is provided.

[0018] In summary, the advantages of the present invention are: (1) The present application can solve a variety of technical problems, including: 1) The texture of dried Atractylodes lancea is firm and takes a long time to moisten, which consumes production manpower and time; 2) The components of fresh products are bound to be lost during the secondary processing of drying and moistening; 3) Incomplete removal of fibrous roots during skinning will affect the qualified rate of ash content; 4) The blooming of Atractylodes lancea is easily misunderstood as mildew, and confusing blooming and mildew will cause waste of resources and affect the safety of drug use.

[0019] In response to these technical problems, the present application adopts a variety of improvement measures during the preparation process, including processing while fresh, peeling after softening, step-by-step drying, and frost inhibition treatment; specifically: 1) Select fresh Atractylodes lancea as the raw material, do not dry it in the sun, and do not need to moisten it, so as to avoid ingredient loss and shorten the preparation time; 2) Use a homemade softener to first soften the fibrous roots of Atractylodes lancea, and then use mechanical peeling to remove the fibrous roots, and then inspect the ash content of the finished product; 3) If Atractylodes lancea is exposed for a long time, the temperature, humidity and other factors in the environment may cause it to frost. In order not to affect the effective ingredients of Atractylodes lancea and inhibit blooming, the present application prepares a homemade bloom inhibitor, which can form a protective film on the surface of Atractylodes lancea; 4) The present application adopts step-by-step drying to gradually dehydrate and maintain the stability of the efficacy. The first drying is to dry to a moisture content of 40% to 50%, the purpose of which is to remove more moisture from Atractylodes macrocephala. The evaporation of moisture in this process helps to avoid the problem of excessive softening or high viscosity in subsequent processing, while reducing the weight and volume of Atractylodes macrocephala in subsequent processes, which is convenient for further processing, but also ensures that the surface of Atractylodes macrocephala will not be over-dried, maintains moderate flexibility, is conducive to subsequent processing and the effect of bloom inhibitors, and is convenient for the formation and attachment of protective films; Second drying: Final drying under low-temperature vacuum conditions can reduce the contact of oxygen with the active ingredients, help avoid the oxidation and degradation of active ingredients in Atractylodes macrocephala such as atractylodesin and volatile oils at high temperatures, thereby avoiding quality deterioration caused by oxidation. This process also helps to maintain the aroma and color of the medicinal materials and ensure the sensory quality of the final product. It also helps the protective film formed by the bloom inhibitor to tightly wrap around the surface of the medicinal materials, thereby reducing the frosting phenomenon, avoiding the loss of effective ingredients, and efficiently retaining the efficacy of Atractylodes macrocephala. 5) In order to cooperate with other technical means, this application selects a slice thickness that is appropriate and suitable for the method of this application to improve the synergistic effect of multiple improvement means of this application.

[0020] (2) The raw materials of the homemade softener of the present application include organic acids, cellulase, and tea polyphenols; the organic acids include malic acid and citric acid. 1) Malic acid and citric acid, as organic acids, can dissolve some cell wall components, making the surface of Atractylodes lancea softer and facilitating the mechanical removal of fibrous roots. 2) Cellulase can hydrolyze cellulose, decompose the main components of plant cell walls, and soften the surface of medicinal materials. 3) Tea polyphenols can capture free radicals, prevent lipid peroxidation, and protect active ingredients such as volatile oils and atractylodesin. Tea polyphenols and citric acid can play a synergistic role and enhance the effect.

[0021] (3) The raw materials of the homemade bloom inhibitor of the present application include perilla extract, cactus extract, and sodium alginate. 1) The active ingredients in the perilla extract can prevent the occurrence of oxidation reactions by capturing free radicals, thereby protecting the active ingredients in Atractylodes macrocephala. Perillaldehyde and other ingredients in the perilla extract can destroy the cell membrane of microorganisms, inhibit their growth and reproduction, and thus reduce the risk of Atractylodes macrocephala being attacked by microorganisms during storage. 2) The polysaccharides and flavonoids in the cactus extract can lock in moisture and capture free radicals, protecting the structure and active ingredients of the medicinal material. 3) Sodium alginate can form a viscous solution in water, forming a uniform protective film on the surface of Atractylodes macrocephala, reducing moisture migration. 4) The antioxidant and antibacterial components in the perilla extract combined with the moisturizing components in the cactus extract can better maintain the moisture balance of Atractylodes macrocephala and prevent microbial contamination and oxidation reactions. This synergistic effect not only improves the storage stability of the medicinal material, but also retains its efficacy.

[0022] (4) The Wumen Medical School's characteristic Atractylodes macrocephala prepared in the examples of the present application performed better in all tests and had better performance, which improved the storage performance of Atractylodes macrocephala and could slow down the frosting speed of Atractylodes macrocephala. Within the appropriate use time, it can avoid confusing the frosting and mildew of Atractylodes macrocephala, avoid waste of resources, improve the safety of Atractylodes macrocephala, and also improve the stability of Atractylodes macrocephala. The stability includes storage stability, ingredient stability, efficacy stability and other aspects. DETAILED DESCRIPTION

[0023] Those skilled in the art can easily understand other advantages and effects of the present application from the contents disclosed in this specification. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. The present application can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present application. It should be noted that the features of the following embodiments and examples can be combined with each other without conflict.

[0024] Example 1 The preparation method of homemade softener is as follows: Dissolve 3 g of malic acid (L-malic acid, product number MF-004262, Xinyang Mufan Biotechnology Co., Ltd.) in 1000 mL of pure water and stir evenly to obtain a homemade softener.

[0025] Example 2 The preparation method of homemade softener is as follows: 0.5 g of cellulase (food grade cellulase, product number MF-010548, Xinyang Mufan Biotechnology Co., Ltd.) was added to 1000 mL of pure water and stirred evenly to obtain a homemade softener.

[0026] Example 3 The preparation method of homemade softener is as follows: Add 2g of citric acid (monohydrate citric acid, food grade, purity ≥ 99.50%, Shandong Lemon Biochemical Co., Ltd.) to 1000mL of pure water and stir until completely dissolved to form an acidic basic solution. Then add 1g of tea polyphenols (food grade, 98% purity, Xinyang Mufan Biotechnology Co., Ltd.) and stir until evenly dissolved to obtain a homemade softener.

[0027] Example 4 The preparation method of homemade softener is as follows: 2 g of citric acid (citric acid monohydrate, food grade, purity ≥ 99.50%, Shandong Lemon Biochemical Co., Ltd.) was added to 1000 mL of pure water and stirred until completely dissolved to obtain a homemade softener.

[0028] Example 5 The preparation method of the bloom inhibitor comprises the following steps: 1 g of perilla extract and 0.5 g of cactus extract were added to 500 mL of pure water and stirred evenly, and then 0.5 g of sodium alginate was added and stirred until it was completely dissolved to obtain a bloom inhibitor.

[0029] Example 6 The preparation method of the bloom inhibitor comprises the following steps: 1 g of perilla extract was added to 500 mL of pure water, and the mixture was stirred evenly. Then, 0.5 g of sodium alginate was added and the mixture was stirred until the mixture was completely dissolved to obtain a bloom inhibitor.

[0030] Example 7 The preparation method of the bloom inhibitor comprises the following steps: 0.5 g of cactus extract was added to 500 mL of pure water and stirred evenly, and then 0.5 g of sodium alginate was added and stirred until it was completely dissolved to obtain a bloom inhibitor.

[0031] Example 8 The processing technology for improving the stability of Atractylodes macrocephala is as follows: 1. Processing while fresh: Take 100g of freshly excavated Atractylodes lancea, put it into 500mL of the homemade softener prepared in Example 3 and soak it for 10 minutes to obtain softened Atractylodes lancea, put the softened Atractylodes lancea into a skin-collision and cleaning machine for 5-10 minutes, and use a drum-type mechanical collision to remove the fibrous roots, check the removal status, and basically remove them. If there are stubborn fibrous roots, cut them off manually. After removing the fibrous roots from Atractylodes lancea, wash Atractylodes lancea, remove the residual softener and other debris, and obtain clean Atractylodes lancea.

[0032] 2. Slicing: Put the cleaned Atractylodes lancea into a traditional Chinese medicine slicer and slice it with a thickness of 3 mm to obtain sliced ​​Atractylodes lancea.

[0033] 3. Drying: Place the sliced ​​Atractylodes lancea in a low-temperature dryer and dry it at 40°C until the moisture content reaches 43% to obtain dried Atractylodes lancea.

[0034] 4. Inhibiting bloom: Soak the dried Atractylodes lancea in the bloom inhibitor of Example 5 at a solid-liquid ratio of 1:5, i.e., use 500 mL of bloom inhibitor for every 100 g of Atractylodes lancea, soak for 5 minutes, and obtain the soaked Atractylodes lancea. 5. Drying: Place the soaked Atractylodes lancea in a vacuum low-temperature dryer and dry it at a temperature of 35°C and a vacuum degree of -0.08 to -0.1 MPa. Dry the dried Atractylodes lancea to a moisture content of ≤11% to obtain the Atractylodes lancea finished product.

[0035] Example 9 The processing technology for improving the stability of Atractylodes macrocephala is as follows: Different from Example 8, the homemade softener prepared in Example 1 is used in fresh processing, and the rest is the same as Example 8.

[0036] Example 10 The processing technology for improving the stability of Atractylodes macrocephala is as follows: Different from Example 8, the homemade softener prepared in Example 2 is used in fresh processing, and the rest is the same as Example 8.

[0037] Embodiment 11 The processing technology for improving the stability of Atractylodes macrocephala is as follows: Different from Example 8, the homemade softener prepared in Example 4 is used in fresh processing, and the rest is the same as Example 8.

[0038] Example 12 The processing technology for improving the stability of Atractylodes macrocephala is as follows: Different from Example 8, the bloom inhibitor of Example 6 is used to suppress blooming, and the rest is the same as Example 8.

[0039] Example 13 The processing technology for improving the stability of Atractylodes macrocephala is as follows: Different from Example 8, the frost inhibitor of Example 7 is used to inhibit frost, and the rest is the same as Example 8.

[0040] Comparative Example 1 The processing technology of Atractylodes macrocephala, without frosting inhibition treatment, is as follows: 1. Fresh processing: Take 100 g of freshly dug Atractylodes lancea, soak it in 500 mL of the self-made softening agent prepared in Example 3 for 10 minutes to obtain softened Atractylodes lancea. Put the softened Atractylodes lancea into a skin-collision and cleaning integrated machine and process it for 5 - 10 minutes. Use a drum-type machine to knock off the fibrous roots, check the removal situation. If the fibrous roots are basically removed, and if there are stubborn fibrous roots, cut them off manually. After removing the fibrous roots of Atractylodes lancea, wash Atractylodes lancea to remove the residual softening agent and other sundries to obtain purified Atractylodes lancea.

[0041] 2. Slicing: Put the purified Atractylodes lancea into a traditional Chinese medicine slicing machine for slicing, with a slice thickness of 3 mm, to obtain sliced Atractylodes lancea.

[0042] 3. Drying: Put the sliced Atractylodes lancea into a vacuum low-temperature dryer for drying, with the temperature set at 35°C and the vacuum degree at -0.08 to -0.1 MPa, and dry until the moisture content ≤ 11% to obtain the finished product of Atractylodes lancea.

[0043] Comparative Example 2 The processing technology of Atractylodes lancea without softening treatment is as follows: 1. Fresh processing: Take 100 g of freshly dug Atractylodes lancea, cut off the fibrous roots with scissors close to the surface of the rhizome, wash it, put Atractylodes lancea into a skin-collision and cleaning integrated machine and process it for 5 - 10 minutes. Use a drum-type machine to knock off the remaining fibrous roots to obtain purified Atractylodes lancea.

[0044] 2. Slicing: Put the purified Atractylodes lancea into a traditional Chinese medicine slicing machine for slicing, with a slice thickness of 3 mm, to obtain sliced Atractylodes lancea.

[0045] 3. Drying: Put the sliced Atractylodes lancea into a low-temperature dryer for drying, with the temperature set at 40°C, and dry until the moisture content is 43% to obtain dried Atractylodes lancea.

[0046] 4. Frost inhibition: Soak the dried Atractylodes lancea in the frost inhibitor of Example 5, with a solid-liquid ratio of 1:5, that is, 500 mL of frost inhibitor is used for every 100 g of Atractylodes lancea, and soak for 5 min to obtain soaked Atractylodes lancea.

[0047] 5. Drying: Put the soaked Atractylodes lancea into a vacuum low-temperature dryer for drying, with the temperature set at 35°C and the vacuum degree at -0.08 to -0.1 MPa, and dry until the moisture content ≤ 11% to obtain the finished product of Atractylodes lancea.

[0048] Comparative Example 3 The traditional processing technology of Atractylodes lancea without choosing fresh processing is as follows: 1. Processing: Take 100g of freshly excavated Atractylodes lancea, dry it in the sun, put the dried Atractylodes lancea into 500mL of the homemade softener prepared in Example 3 and soak it for 10 minutes to obtain softened Atractylodes lancea, put the softened Atractylodes lancea into a skin-collision and cleaning all-in-one machine for 5-10 minutes, and use a drum-type mechanical collision to remove the fibrous roots, check the removal situation, and basically remove them. If there are stubborn fibrous roots, cut them off manually. After removing the fibrous roots from Atractylodes lancea, wash Atractylodes lancea, remove the residual softener and other debris, and obtain a clean Atractylodes lancea.

[0049] 2. Slicing: Put the cleaned Atractylodes lancea into a traditional Chinese medicine slicer and slice it with a thickness of 3 mm to obtain sliced ​​Atractylodes lancea.

[0050] 3. Drying: Place the sliced ​​Atractylodes lancea in a low-temperature dryer and dry it at 40°C until the moisture content reaches 43% to obtain dried Atractylodes lancea.

[0051] 4. Inhibiting bloom: Soak the dried Atractylodes lancea in the bloom inhibitor of Example 5 at a solid-liquid ratio of 1:5, i.e., use 500 mL of bloom inhibitor for every 100 g of Atractylodes lancea, soak for 5 minutes, and obtain the soaked Atractylodes lancea.

[0052] 5. Drying: Place the soaked Atractylodes lancea in a vacuum low-temperature dryer and dry it at a temperature of 35°C and a vacuum degree of -0.08 to -0.1 MPa. Dry the dried Atractylodes lancea to a moisture content of ≤11% to obtain the Atractylodes lancea finished product.

[0053] Comparative Example 4 The processing technology of Atractylodes macrocephala, without softening treatment and bloom inhibition treatment, is as follows: 1. Process while fresh: Take 100g of freshly dug Atractylodes lancea, wash it, use a drum-type machine to knock out the fibrous roots, check the removal status, and basically remove them. If there are stubborn fibrous roots, cut them off manually to obtain clean Atractylodes lancea.

[0054] 2. Slicing: Put the cleaned Atractylodes lancea into a traditional Chinese medicine slicer and slice it with a thickness of 3 mm to obtain sliced ​​Atractylodes lancea.

[0055] 3. Drying: Dry the sliced ​​Atractylodes lancea in the sun until the moisture content is ≤11% to obtain the finished Atractylodes lancea.

[0056] Comparative Example 5 The processing technology of Atractylodes macrocephala does not involve fresh processing, softening, or frosting inhibition. The steps are as follows: 1. Processing: Take 100g of freshly dug Atractylodes lancea, dry it in the sun, use a drum-type machine to knock out the fibrous roots, check the removal status, and basically remove them. If there are stubborn fibrous roots, cut them off manually, wash them, and get the purified Atractylodes lancea.

[0057] 2. Slicing: Put the cleaned Atractylodes lancea into a traditional Chinese medicine slicer and slice it with a thickness of 3 mm to obtain sliced ​​Atractylodes lancea.

[0058] 3. Drying: Dry the sliced ​​Atractylodes lancea in the sun until the moisture content is ≤11% to obtain the finished Atractylodes lancea.

[0059] It should be noted that Unless otherwise specified, the equipment and materials used in the embodiments and comparative examples can be easily obtained from commercial companies.

[0060] Among them, the integrated skin-peeling and cleaning machine uses conventional Atractylodes lancea medicine making machines on the market, which have the functions of skin-peeling and cleaning. For example, the TM-10 Atractylodes lancea skin-peeling / cleaning / peeling machine produced by Bole Machinery Factory in Liuze Town, Shaodong County, has the functions of water washing, whisker removal and skin-peeling.

[0061] Perilla extract: Perilla seed extract, food grade, 99% purity, Hanzhong Hansuyuan Biotechnology Co., Ltd.

[0062] Cactus extract: food grade water-soluble cactus powder, product number REL0797, Xi'an Ruierli Bioengineering Co., Ltd.

[0063] Detection: 1. Detection of frosting inhibition effect: Take 20 samples of each Atractylodes lancea finished product without sealing the packaging, expose and store them in a standard storage environment (temperature 20°C, humidity 60%RH) for 1 year.

[0064] Check the sample surface every day to see if there is any frost-like substance generated, and record the time when frost appears.

[0065] Before and at the end of storage, the samples were weighed and the weight change caused by blooming was calculated: weight change (%) = [(initial weight of the sample before storage - weight of the sample at the end of storage) / initial weight of the sample before storage] × 100%.

[0066] Judgment criteria: late frost onset and small weight change indicate good frost inhibition effect.

[0067] 2. Active ingredient retention rate The following is the determination of ingredients such as atractylodesin and volatile oil: According to the high performance liquid chromatography method (General Rule 0512) in the 2020 edition of the Chinese Pharmacopoeia, atractylodesin (C 13 H 10 O) content, the pharmacopoeia requires no less than 0.30%.

[0068] The volatile oil content is determined according to Method B of the Volatile Oil Determination Method (General Rule 2204) in the 2020 edition of the Chinese Pharmacopoeia. The Pharmacopoeia requires that the volatile oil content of Atractylodes lancea should not be less than 2.5% (ml / g).

[0069] 3.Total ash The total ash content is determined in accordance with the Chinese Pharmacopoeia 2020 edition (General Chapter 2302), and the total ash content is required to be no more than 5.0%.

[0070] 4. The results are shown in Table 1 below.

[0071] Table 1

[0072] Refer to Table 1 and analyze: By comparing Examples 8 to 13, it can be seen that 1) the softener prepared by compounding citric acid and tea polyphenols has the best effect on fibrous root treatment and the lowest ash content; 2) the bloom inhibitor prepared by compounding perilla extract, cactus extract and sodium alginate has the best bloom inhibition effect on Atractylodes lancea, and the blooming time of Atractylodes lancea is the latest under exposure; 3) Instead of drying Atractylodes lancea, fresh Atractylodes lancea is used as a raw material for direct softening treatment, which can reduce the loss of effective ingredients of Atractylodes lancea.

[0073] By comparing Comparative Examples 1 to 5, it can be seen that 1) the homemade softener of the present application can improve the removal rate of fibrous roots; 2) the homemade frost inhibitor and fresh processing can effectively reduce the loss of effective ingredients of Atractylodes lancea.

[0074] Comparing the examples with the comparative examples, it can be seen that the homemade softener of the present application can improve the removal rate of fibrous roots, the homemade bloom inhibitor and fresh processing can effectively reduce the loss of effective ingredients of Atractylodes macrocephala, and the various improvement methods of the present application also have a synergistic effect, which synergistically improves the performance of the finished product. The Wumen Medical School's characteristic Atractylodes macrocephala prepared in the examples of the present application performed better in various tests and had better performance, improved the storage performance of Atractylodes macrocephala, and could slow down the blooming speed of Atractylodes macrocephala. Within the appropriate use time, it can avoid confusing the blooming and mildew of Atractylodes macrocephala, improve the medication safety of Atractylodes macrocephala, and also improve the stability of Atractylodes macrocephala, and the stability includes storage stability, ingredient stability, efficacy stability and other aspects.

[0075] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A processing process for improving the stability of Atractylodes macrocephala, characterized in that: The steps include: The Atractylodes lancea is softened, peeled, cleaned, sliced, dried for the first time, subjected to a frosting prevention treatment, and dried for the second time to a finished product.

2. The processing process for improving the stability of Atractylodes macrocephala according to claim 1, characterized in that: The method for softening Atractylodes lancea is to soak fresh Atractylodes lancea in a homemade softener, wherein the raw materials of the homemade softener include at least one of organic acid, cellulase and tea polyphenols.

3. The processing process for improving the stability of Atractylodes macrocephala according to claim 2, characterized in that: The organic acid includes at least one of malic acid and citric acid.

4. The processing process for improving the stability of Atractylodes macrocephala according to claim 2, characterized in that: The homemade softener is obtained by dissolving its raw materials in water, and the mass ratio of the raw materials to water is 0.2-10:1000.

5. The processing process for improving the stability of Atractylodes lancea according to claim 1, characterized in that: The bloom inhibition treatment is to soak the dried Atractylodes lancea in a bloom inhibitor, wherein the raw material of the bloom inhibitor includes at least one of a perilla extract, a cactus extract, and sodium alginate.

6. The processing process for improving the stability of Atractylodes macrocephala according to claim 5, characterized in that: The bloom inhibitor is obtained by dissolving its raw material in water, and the mass ratio of the raw material to water is 0.5-10:1000.

7. The processing process for improving the stability of Atractylodes macrocephala according to claim 5, characterized in that: During the bloom inhibition treatment, the solid-to-liquid ratio of the dried Atractylodes lancea and the bloom inhibitor is 1:1-8.

8. The processing process for improving the stability of Atractylodes macrocephala according to claim 1, characterized in that: The first drying is to dry the sliced ​​Atractylodes lancea to a moisture content of 40% to 50%, and the first drying temperature is 35 to 80°C.

9. The processing process for improving the stability of Atractylodes macrocephala according to claim 1, characterized in that: The second drying is to dry the Atractylodes lancea after the frost inhibition treatment to a moisture content of ≤11%. The temperature of the second drying is 35~60℃, and the vacuum degree is -0.08~-0.1 MPa.

10. The processing process for improving the stability of Atractylodes macrocephala according to claim 5, characterized in that: The preparation method of the blooming inhibitor comprises the following steps: adding perilla extract and / or cactus extract into water, stirring evenly, and then adding sodium alginate, stirring until the mixture is completely dissolved, thereby obtaining the blooming inhibitor.

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