Ginger-processed Singceltis tablet and preparation method thereof
Through low-temperature freezing treatment and composite liquid film formation technology, ginger-made star pulp tablets were prepared, which solved the problem of low dissolution rate and decoction rate of traditional Chinese medicinal materials in traditional preparation methods, and achieved more efficient dissolution and antibacterial effects of active medicinal materials.
Patent Information
- Application Number
- CN202510224132.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-27
- Publication Date
- 2025-05-23
AI Technical Summary
The traditional preparation method of ginger Magnolia officinalis is not standardized and lacks a certain process flow and parameter range, resulting in a low dissolution rate and decoction rate of effective medicinal materials.
The medicinal materials of Magnolia officinalis are treated with low temperature freezing, and the composite liquid and film-forming liquid are added. After heat treatment and moistening process, a ginger star slab is formed. The composite liquid contains ginger juice, sodium chloride, saccharase, amylase and gelatin, and the film-forming liquid contains chitosan and plant extract.
It improves the precipitation and decoction rate of effective substances in Magnolia officinalis medicinal materials, enhances the antibacterial effect of ginger-made Xingpu tablets, and improves the standardization and efficiency of the preparation process of medicinal materials.
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Abstract
Description
Technical Field
[0001] The invention relates to the field of Chinese medicinal pieces, and in particular to ginger-processed galangal slices and a preparation method thereof. Background Art
[0002] Magnolia officinalis is the dried bark, root bark and branch bark of Magnolia officinalis Rehd.et Wils. or Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils. of the Magnoliaceae family. It is mainly produced in Sichuan, Hubei, Hunan, Guizhou, Zhejiang, Jiangxi, Anhui, Fujian, Yunnan and other provinces. The main index components of Magnolia officinalis, magnolol and honokiol, can scavenge peroxy and superoxide free radicals, have antioxidant effects, and have significant inhibitory effects on five cariogenic bacteria, including Streptococcus mutans, Streptococcus sanguis, Actinomyces naeslundii, Actinomyces viscous and Lactobacillus. In addition, studies have shown that Magnolia officinalis and its chemical components also have cardiovascular and cerebrovascular effects such as myocardial protection and cerebral ischemia protection, central nervous system effects such as anti-anxiety, anti-depression, and anti-Alzheimer's disease, as well as many pharmacological effects such as anti-tumor and anti-ulcer. However, since raw Magnolia officinalis has a pungent and strong nature and is irritating to a certain extent, it needs to be processed; the traditional preparation method of Magnolia officinalis is not standardized, without a definite process flow and parameter range, and the dissolution rate and decoction rate of the effective substances in the preparation process are very low. Summary of the invention
[0003] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art and to provide a ginger processed star apple slice and a preparation method thereof.
[0004] The technical solution of the present invention is as follows:
[0005] A preparation method of ginger-processed star magnolia slices comprises the following steps: taking a magnolia bark medicinal material, washing, moistening, cutting into strips or slices, and then subjecting it to low-temperature freezing treatment, adding a composite liquid, stirring it evenly, spraying a film-forming liquid, steaming it, taking it out, and then subjecting it to heat treatment at 160-180° C., steaming it in a sealed pile until the inside and outside are dark brown and small white stars appear on the cross section, taking it out, drying it, and sieving it to obtain the product;
[0006] The compound liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin;
[0007] The preparation method of the film-forming solution is as follows:
[0008] Weigh chitosan, add acetic acid solution accounting for 1-3wt% of chitosan, heat to dissolve, obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol to obtain.
[0009] As a preferred embodiment of the present invention, the added amounts of ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin are: 5-8:1-3:0.1-0.5:0.1-0.3:10-30.
[0010] As a preferred embodiment of the present invention, the preparation method of the ginger juice is: prepare water of equal weight to ginger, chop fresh ginger, add water to squeeze juice, filter, squeeze juice from ginger residue and remaining water, filter again, and mix the two filtrates to obtain ginger juice.
[0011] As a preferred embodiment of the present invention, the temperature of the low-temperature freezing treatment is -20 to -5°C, and the treatment time is 10 to 12 hours.
[0012] As a preferred embodiment of the present invention, after the low-temperature freezing treatment, ultraviolet irradiation is adopted, and then the composite liquid is added.
[0013] As a preferred embodiment of the present invention, the preparation method of the plant extract is as follows: 5-10 parts by weight of licorice, 10-20 parts by weight of aloe, and 5-8 parts of tea are crushed, added into 4-6 times the weight of water, heated to 70-100°C with microwave treatment at a frequency of 400-700 MHz, then ultrasonically treated with a power of 1000-2000w for 20-40min, filtered to obtain a filtrate, and then added with lactic acid or rice vinegar to obtain a plant extract.
[0014] As a preferred embodiment of the present invention, the plant extract accounts for 5-20wt% of the chitosan solution.
[0015] As a preferred embodiment of the present invention, the heat treatment is performed until the water content of Magnolia officinalis is 10-25%.
[0016] A ginger processed starfruit slice is prepared by adopting the above preparation method.
[0017] The beneficial effects of the present invention are:
[0018] The invention freeze-dries the magnolia bark first to make it have a loose and porous structure, and then treats it in a composite liquid, combines it with a film-forming liquid, makes it fully swell, and fully dissolves the active substance, and the gelatin in the composite liquid and the chitosan used in the film-forming liquid can complex tannins, and ginger juice, amylase and saccharifying enzyme play an enzymatic reaction, improve the moistening effect, and increase the precipitation and decoction rate of the effective substance. In addition, a plant extract is added to the chitosan, and the plant extract can further promote the dissolution of the magnolia bark active substance during film formation, thereby improving the antibacterial effect of the ginger-processed magnolia bark slices. DETAILED DESCRIPTION
[0019] The embodiments of the present invention are described in detail below. The embodiments described below are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. If no specific techniques or conditions are specified in the embodiments, the techniques or conditions described in the literature in this area or the product specifications are used. The reagents or instruments used that do not specify the manufacturer are all conventional products that can be obtained commercially.
[0020] In the following embodiments, the amylase is specifically α-amylase, and the saccharifying enzyme is specifically α-1,4-glucose hydrolase.
[0021] Example 1
[0022] A preparation method of ginger-processed star bark slices comprises the following steps: taking a magnolia bark medicinal material, washing, moistening, slicing, and then subjecting the material to low-temperature freezing treatment, adding a composite liquid of 5 times the weight of magnolia bark slices, stirring evenly, spraying a film-forming liquid of 1 times the weight of magnolia bark slices, moistening, taking out, and then heat-treating at 170°C until the water content of the magnolia bark is 15%, and sealing and stacking until the inside and outside of the magnolia bark are dark brown and small white stars appear on the cross section, taking out, drying, and sieving to obtain the magnolia bark slices;
[0023] The composite liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin in the mass addition ratio of 5:1:0.1:0.3:20;
[0024] The preparation method of the film-forming solution is as follows:
[0025] Weigh chitosan, add acetic acid solution accounting for 2wt% of chitosan, the concentration of acetic acid solution is 1wt%, heat and dissolve to obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol accounting for 3wt% of the chitosan solution to obtain. The plant extract accounts for 5wt% of the chitosan solution.
[0026] The ginger juice preparation method comprises the following steps: preparing water of equal weight to ginger, chopping fresh ginger, adding water to squeeze out juice, filtering, squeezing out juice from ginger residue and remaining water, filtering again, and mixing the two filtrates to obtain ginger juice.
[0027] The temperature of the low-temperature freezing treatment is -15°C and the treatment time is 10 hours.
[0028] After low-temperature freezing treatment, ultraviolet irradiation with a wavelength of 365nm was used for 20 minutes, and then the composite liquid was added.
[0029] The preparation method of the plant extract is as follows: 8 parts by weight of licorice, 13 parts by weight of aloe vera, and 7 parts of tea are crushed, added into 5 times the weight of water, heated to 80°C by microwave treatment with a frequency of 500 MHz, then ultrasonically treated for 30 minutes with a power of 1500 w, filtered to obtain a filtrate, and then lactic acid accounting for 5 wt% of the filtrate is added to obtain a plant extract.
[0030] Example 2
[0031] A preparation method of ginger-processed star bark slices comprises the following steps: taking a magnolia bark medicinal material, washing, moistening, slicing, and then subjecting the material to low-temperature freezing treatment, adding a composite liquid of 5 times the weight of magnolia bark slices, stirring evenly, spraying a film-forming liquid of 1 times the weight of magnolia bark slices, moistening, taking out, and then heat-treating at 170°C until the water content of the magnolia bark is 15%, and sealing and stacking until the inside and outside of the magnolia bark are dark brown and small white stars appear on the cross section, taking out, drying, and sieving to obtain the magnolia bark slices;
[0032] The composite liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin in the mass addition ratio of 6:2:0.3:0.1:30;
[0033] The preparation method of the film-forming solution is as follows:
[0034] Weigh chitosan, add acetic acid solution accounting for 1wt% of chitosan, the concentration of acetic acid solution is 1wt%, heat and dissolve to obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol accounting for 5wt% of the chitosan solution to obtain. The plant extract accounts for 6wt% of the chitosan solution.
[0035] The ginger juice preparation method comprises the following steps: preparing water of equal weight to ginger, chopping fresh ginger, adding water to squeeze out juice, filtering, squeezing out juice from ginger residue and remaining water, filtering again, and mixing the two filtrates to obtain ginger juice.
[0036] The temperature of the low-temperature freezing treatment is -15°C and the treatment time is 10 hours.
[0037] After low-temperature freezing treatment, ultraviolet irradiation with a wavelength of 365nm was used for 20 minutes, and then the composite liquid was added.
[0038] The preparation method of the plant extract is as follows: 8 parts by weight of licorice, 12 parts by weight of aloe vera, and 7 parts of tea are crushed, added into 5 times the weight of water, heated to 80°C by microwave treatment with a frequency of 500 MHz, then ultrasonically treated for 30 minutes with a power of 1500 w, filtered to obtain a filtrate, and then lactic acid accounting for 5 wt% of the filtrate is added to obtain a plant extract.
[0039] Example 3
[0040] A preparation method of ginger-processed star bark slices comprises the following steps: taking a magnolia bark medicinal material, washing, moistening, slicing, and then subjecting the material to low-temperature freezing treatment, adding a composite liquid of 5 times the weight of magnolia bark slices, stirring evenly, spraying a film-forming liquid of 1 times the weight of magnolia bark slices, moistening, taking out, and then heat-treating at 170°C until the water content of the magnolia bark is 15%, and sealing and stacking until the inside and outside of the magnolia bark are dark brown and small white stars appear on the cross section, taking out, drying, and sieving to obtain the magnolia bark slices;
[0041] The composite liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin in the mass addition ratio of 8:2:0.3:0.2:30;
[0042] The preparation method of the film-forming solution is as follows:
[0043] Weigh chitosan, add acetic acid solution accounting for 1wt% of chitosan, the concentration of acetic acid solution is 1wt%, heat and dissolve to obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol accounting for 5wt% of the chitosan solution to obtain. The plant extract accounts for 6wt% of the chitosan solution.
[0044] The ginger juice preparation method comprises the following steps: preparing water of equal weight to ginger, chopping fresh ginger, adding water to squeeze out juice, filtering, squeezing out juice from ginger residue and remaining water, filtering again, and mixing the two filtrates to obtain ginger juice.
[0045] The temperature of the low-temperature freezing treatment is -20°C and the treatment time is 10 hours.
[0046] After low-temperature freezing treatment, ultraviolet irradiation with a wavelength of 365nm was used for 20 minutes, and then the composite liquid was added.
[0047] The preparation method of the plant extract is as follows: 10 parts by weight of licorice, 18 parts by weight of aloe vera, and 8 parts of tea are crushed, added into 5 times the weight of water, heated to 80° C. by microwave treatment with a frequency of 600 MHz, then ultrasonically treated for 30 minutes with a power of 1500 w, filtered to obtain a filtrate, and then rice vinegar accounting for 5wt% of the filtrate is added to obtain a plant extract.
[0048] Example 4
[0049] A preparation method of ginger-processed star bark slices comprises the following steps: taking a magnolia bark medicinal material, washing, moistening, slicing, and then subjecting the material to low-temperature freezing treatment, adding a composite liquid of 5 times the weight of magnolia bark slices, stirring evenly, spraying a film-forming liquid of 1 times the weight of magnolia bark slices, moistening, taking out, and then heat-treating at 180°C until the water content of the magnolia bark is 25%, sealing and stacking until the inside and outside are dark brown and small white stars appear on the cross section, taking out, drying, and sieving to obtain the product;
[0050] The composite liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin in the mass addition ratio of 7:1:0.2:0.1:20;
[0051] The preparation method of the film-forming solution is as follows:
[0052] Weigh chitosan, add acetic acid solution accounting for 1wt% of chitosan, the concentration of acetic acid solution is 1wt%, heat and dissolve to obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol accounting for 5wt% of the chitosan solution to obtain. The plant extract accounts for 10wt% of the chitosan solution.
[0053] The ginger juice preparation method comprises the following steps: preparing water of equal weight to ginger, chopping fresh ginger, adding water to squeeze out juice, filtering, squeezing out juice from ginger residue and remaining water, filtering again, and mixing the two filtrates to obtain ginger juice.
[0054] The temperature of the low-temperature freezing treatment is -10°C and the treatment time is 12 hours.
[0055] After low-temperature freezing treatment, ultraviolet irradiation with a wavelength of 365nm was used for 20 minutes, and then the composite liquid was added.
[0056] The preparation method of the plant extract is as follows: 8 parts by weight of licorice, 15 parts by weight of aloe vera, and 7 parts of tea leaves are crushed, added into 6 times the weight of water, heated to 100° C. by microwave treatment with a frequency of 700 MHz, then ultrasonically treated for 20 minutes with a power of 2000 W, filtered to obtain a filtrate, and then added with lactic acid or rice vinegar to obtain a plant extract.
[0057] Example 5
[0058] A preparation method of ginger-processed star bark slices comprises the following steps: taking a magnolia bark medicinal material, washing, moistening, slicing, and then subjecting the material to low-temperature freezing treatment, adding a composite liquid of 5 times the weight of magnolia bark slices, stirring evenly, spraying a film-forming liquid of 1 times the weight of magnolia bark slices, moistening, taking out, and then heat-treating at 180°C until the water content of the magnolia bark is 15%, and sealing and stacking until the inside and outside of the magnolia bark are dark brown and small white stars appear on the cross section, taking out, drying, and sieving to obtain the magnolia bark slices;
[0059] The composite liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin in the mass addition ratio of 8:3:0.5:0.3:30;
[0060] The preparation method of the film-forming solution is as follows:
[0061] Weigh chitosan, add acetic acid solution accounting for 3wt% of chitosan, the concentration of acetic acid solution is 1wt%, heat and dissolve to obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol accounting for 5wt% of the chitosan solution to obtain. The plant extract accounts for 9wt% of the chitosan solution.
[0062] The ginger juice preparation method comprises the following steps: preparing water of equal weight to ginger, chopping fresh ginger, adding water to squeeze out juice, filtering, squeezing out juice from ginger residue and remaining water, filtering again, and mixing the two filtrates to obtain ginger juice.
[0063] The temperature of the low-temperature freezing treatment is -15°C and the treatment time is 12 hours.
[0064] After low-temperature freezing treatment, ultraviolet irradiation with a wavelength of 365nm was used for 20 minutes, and then the composite liquid was added.
[0065] The preparation method of the plant extract is as follows: 8 parts by weight of licorice, 15 parts by weight of aloe vera, and 7 parts of tea leaves are crushed, added into 5 times the weight of water, heated to 80° C. by microwave treatment with a frequency of 500 MHz, then subjected to ultrasonic treatment with a power of 1500 W for 30 minutes, filtered to obtain a filtrate, and then lactic acid or rice vinegar is added to obtain the plant extract.
[0066] Comparative Example 1
[0067] The difference from Example 2 is that the composite liquid is ginger juice, and the rest is the same as Example 2.
[0068] Comparative Example 2
[0069] The difference from Example 2 is that the mixture is directly moistened after being stirred evenly without spraying the membrane-forming liquid. The rest is the same as Example 2.
[0070] Comparative Example 3
[0071] The difference from Example 2 is that no plant extract is added to the film-forming liquid, that is, the preparation method of the film-forming liquid is as follows:
[0072] Weigh chitosan, add 1wt% acetic acid solution, heat to dissolve, obtain chitosan solution, mix well, and continue to add 5wt% glycerol to obtain the chitosan solution.
[0073] Comparative Example 4
[0074] The difference from Example 2 is that no glycerol is added to the film-forming liquid, that is, the preparation method of the film-forming liquid is as follows:
[0075] Weigh chitosan, add 1wt% acetic acid solution, heat to dissolve, obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and obtain the chitosan solution. The plant extract accounts for 6wt% of the chitosan solution.
[0076] Comparative Example 5
[0077] The difference from Example 2 is that no low-temperature freezing treatment is performed, and the rest is the same as Example 2.
[0078] The above embodiments and comparative examples were subjected to performance tests, and the test results are shown in Table 1.
[0079] (1) The unprocessed Magnolia officinalis slices, the processed Magnolia officinalis slices of the embodiment and the comparative example were respectively added with 10 times the weight of water and decocted for 60 minutes, the residues were extracted once, the decoctions were combined, and the contents of magnolol and honokiol in the decoctions were determined by HPLC, and the total increase rate of magnolol and honokiol was calculated.
[0080] At the same time, the above decoction was concentrated to 50 ml as the sample solution, and diluted to a concentration of 0.5 g / ml in multiple ratios. Antibacterial tests were performed on Streptococcus mutans, Escherichia coli and Pseudomonas aeruginosa. The content of each test bacteria before antibacterial was 1×10 8 CFU / L, the antibacterial test temperature was 37°C, the antibacterial time was 24h, and the test antibacterial rate = (bacterial concentration before the test - bacterial concentration after the test) / bacterial concentration before the test.
[0081] Table 1 Performance test results of embodiments and comparative examples
[0082] Sample Total increase rate of magnolol and honokiol (%) Example 1 43.2 Example 2 43.5 Example 3 42.9 Example 4 43.1 Example 5 43.3 Comparative Example 1 26 Comparative Example 2 35 Comparative Example 3 33 Comparative Example 4 32 Comparative Example 5 38 Raw Magnolia officinalis -
[0083] From the above experimental results, it can be seen that the performance of the embodiment is better than that of the comparative example. The main reason may be: from the analysis of comparative examples 1-5, it can be seen that in the embodiment, the magnolia bark is first freeze-dried to have a loose and porous structure, and then treated in a composite liquid, combined with a film-forming liquid, so that it is fully swollen and the active substance is fully dissolved. In addition, the gelatin in the composite liquid and the chitosan used in the film-forming liquid can complex tannins. At the same time, ginger juice, amylase and saccharifying enzyme play an enzymatic reaction, improve the moistening effect, and increase the precipitation and decoction rate of effective substances. In addition, when a plant extract is added to the chitosan, the plant extract can further promote the dissolution of the active substances of the magnolia bark while forming the film, and improve the effect of the ginger-made magnolia bark slices. Moreover, the addition of glycerol improves the performance of the film, thereby increasing the precipitation and decoction rate of effective substances.
[0084] Table 2 Antibacterial results of the embodiments and comparative examples
[0085]
[0086] It can be seen from the above table that the antibacterial performance of the embodiment is significantly improved compared with the magnolia bark before processing and the comparative example, which is mainly due to the significant increase in the content of magnolia bark and honokiol, and magnolia bark and honokiol have good lipophilicity, can be inserted into the phospholipid bilayer of the bacterial cell membrane, change the permeability of the cell membrane, and cause important substances in the cell such as amino acids and nucleotides to leak out, interfere with the normal metabolism and physiological functions of bacteria, thereby inhibiting bacterial growth and reproduction. In addition, magnolia bark and honokiol can inhibit the formation of bacterial biofilms, making bacteria more easily exposed to the external environment and antibacterial drugs, thereby more easily being removed, thereby improving the antibacterial effect.
[0087] The above-mentioned embodiments only express the preferred implementation modes of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, various other corresponding changes and deformations can be made according to the technical solutions and concepts described above, and all these changes and deformations should fall within the scope of protection of the claims of the present invention.
Claims
1. A method for preparing ginger-processed starfruit slices, characterized in that: Take Magnolia officinalis, wash, moisten, cut into strips or slices, and then freeze it at low temperature, add compound liquid, stir evenly, spray film-forming liquid, moisten, take it out, and then heat treat it at 160-180℃, seal and pile until it is dark brown inside and outside, and white small stars appear on the cross section, take it out to dry, sieve, and make it; The compound liquid contains ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin; The preparation method of the film-forming solution is as follows: Weigh chitosan, add acetic acid solution accounting for 1-3wt% of chitosan, heat to dissolve, obtain chitosan solution, then add plant extract to the chitosan solution, mix well, and continue to add glycerol to obtain.
2. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: The mass addition amounts of the ginger juice, sodium chloride, saccharifying enzyme, amylase and gelatin are: 5-8:1-3:0.1-0.5:0.1-0.3:10-30.
3. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: The ginger juice preparation method comprises the following steps: preparing water of equal weight to ginger, chopping fresh ginger, adding water to squeeze out juice, filtering, squeezing out juice from ginger residue and remaining water, filtering again, and mixing the two filtrates to obtain ginger juice.
4. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: The temperature of the low-temperature freezing treatment is -20 to -5°C, and the treatment time is 10 to 12 hours.
5. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: After low temperature freezing treatment, ultraviolet irradiation is used, and then the composite liquid is added.
6. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: The preparation method of the plant extract is as follows: 5-10 parts by weight of licorice, 10-20 parts by weight of aloe vera and 5-8 parts of tea are crushed, added into 4-6 times the weight of water, heated to 70-100° C. by microwave treatment with a frequency of 400-700 MHz, then ultrasonically treated with a power of 1000-2000 w for 20-40 min, filtered to obtain a filtrate, and then added with lactic acid or rice vinegar to obtain the plant extract.
7. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: The plant extract accounts for 5-20 wt % of the chitosan solution.
8. The method for preparing ginger-processed starfruit slices according to claim 1, characterized in that: The heat treatment is performed until the water content of Magnolia officinalis is 10-25%.
9. A ginger-processed starfruit slice, characterized in that: The method is prepared by any one of claims 1 to 8.