Desktop type penicillin bottle low-temperature filling, plugging and capping all-in-one machine

Abstract

The invention relates to a desktop type penicillin bottle low-temperature filling, plugging and capping all-in-one machine. The all-in-one machine comprises an arranging and feeding mechanism, a filling mechanism, a stepping type rail conveying mechanism, a plugging and capping mechanism, a capping dust collection mechanism, a discharging mechanism, a waste discharging box and an equipment case. The equipment case is of a desktop type, and the sorting and feeding mechanism is used for adjusting the positions of penicillin bottles and conveying the penicillin bottles to the stepping type rail conveying mechanism. The filling mechanism is used for conducting raw material filling on the penicillin bottles on the stepping type rail conveying mechanism. The plugging and capping mechanism is used for adding rubber plugs and aluminum caps to penicillin bottles; the capping dust collection mechanism is used for capping penicillin bottles and absorbing aluminum scraps generated in the capping process; the discharging mechanism is used for screening and collecting the penicillin bottles with qualified filling, and the waste discharging box is used for collecting the penicillin bottles with unqualified filling.

Description

Technical Field

[0001] The invention relates to the technical field of vial filling, in particular to a desktop vial low-temperature filling, plugging and capping integrated machine. Background Art

[0002] At present, most of the filling, plugging and capping machines on the market are vertical structures, occupying a large area, and need to be customized for use in isolators according to the application scenarios; in the process of vial packaging production reagents, in order to avoid the impact of aluminum chips in the capping process on the production environment and drug pollution, the filling, plugging and capping processes are completed on different production lines, which leads to reduced production efficiency and increased space requirements, which has certain shortcomings; the filling equipment is not equipped with a low-temperature mixing module, which cannot meet the needs of low-temperature storage of solutions during the filling process; and currently, in order to achieve the low-temperature filling needs in the isolator, a low-temperature device is usually added outside the isolator, and the solution is transferred to the isolator through the aseptic material transfer system to complete the filling, but the material transfer system is a disposable product and expensive. In addition, in the later stage of low-temperature filling, the solution is significantly reduced, and it is difficult to achieve mixing. Existing filling equipment can only meet the filling needs of one specification alone, and cannot meet the filling needs of multiple specifications and models; filling equipment mostly requires an external air source, and the air converts heat energy into mechanical energy through expansion in the cylinder. If used in an isolator, the matching isolator is required to have a reserved port for an external air source. If the isolator has no reserved opening, drilling is required, which may damage the isolator's pressure protection system, sealed airflow system, etc. Summary of the invention

[0003] The present invention provides a desktop type low-temperature filling, plugging and capping integrated machine for vials, comprising a material sorting and feeding mechanism, a filling mechanism, a stepping track transmission mechanism, a plugging and capping mechanism, a capping and dust collecting mechanism, a material unloading mechanism, a waste discharge box, and an equipment chassis; the equipment chassis is desktop type, and the material sorting and feeding mechanism, the filling mechanism, the stepping track transmission mechanism, the plugging and capping mechanism, the capping and dust collecting mechanism, the material unloading mechanism, and the waste discharge box are all arranged above the equipment chassis; The material sorting and loading mechanism is used to adjust the position of the vials and transmit them to the step-by-step track transmission mechanism; the filling mechanism is used to fill the vials on the step-by-step track transmission mechanism with raw materials; the stoppering and capping mechanism is used to add rubber stoppers and aluminum caps to the vials; the capping and dust suction mechanism is used to cap the vials and absorb aluminum chips generated during the capping process; the unloading mechanism is used to screen and collect vials that have passed the filling process, and the waste discharge box is used to collect vials that have failed the filling process.

[0004] Furthermore, the step-by-step track transmission mechanism includes a product conveying and positioning track, a quick-change transport claw, a transport servo module, and an avoidance electric cylinder module; The handling servo module drives the avoidance electric cylinder module to move back and forth in the first direction. The avoidance electric cylinder module is fixedly connected to the quick-change handling gripper and drives the quick-change handling gripper to move back and forth in the second direction. A plurality of semi-circular grooves matching the body of the vial are arranged on the quick-change handling gripper. The vial is transported from the sorting and feeding mechanism to the product conveying and positioning track by the quick-change handling gripper. The first direction is the transmission direction of the vial on the product conveying and positioning track; the second direction is perpendicular to the first direction and parallel to the plane of the product conveying and positioning track.

[0005] Further, the stopper and capping mechanism includes a rubber stopper vibrating disk, an aluminum cap vibrating disk, and a rubber stopper and aluminum cap transplanting mechanism. The rubber stopper vibrating disk is provided with a rubber stopper conveying groove and a rubber stopper discharge port. The aluminum cap vibrating disk is provided with an aluminum cap conveying groove and an aluminum cap discharge port. The rubber stopper and aluminum cap transplanting mechanism is provided with a rubber stopper gripper and an aluminum cap gripper.

[0006] Further, the rubber stopper discharge port and the aluminum cap discharge port are on one workpiece.

[0007] Further, the capping and dust suction mechanism includes a capping cutter head, a dust suction device, and a capping sealing device. The capping sealing device includes a stainless steel capping cover and a transition joint. The dust suction device includes a dust suction device outer cover, a dust suction device upper cover, a dust suction fan, and a filter element. The stainless steel capping cover is fixedly connected to the transition joint by a thread to form a cavity for accommodating the cap part of the vial. The capping cutter head is located inside the cavity. The stainless steel capping cover and the capping cutter head can move up and down synchronously. The transition joint is provided with an interface connected to the dust suction device, so as to connect the dust suction device with the cavity.

[0008] Further, the stainless steel capping cover is fixed on the capping lifting shaft. By the descent of the capping lifting shaft, the stainless steel capping cover and the transition joint wrap the capping cutter head and move downward simultaneously. The cap part of the vial enters the cavity. By the ascent of the capping lifting shaft, the cap part of the vial exits the cavity.

[0009] Further, when the capping cutter head is working, the dust suction device is turned on, and the aluminum chips generated during capping are sucked into the filter element through a pipeline.

[0010] Further, the integrated machine further includes a raw liquid low-temperature mixing device, which is used for mixing and temperature control of the raw liquid to be filled. The stock solution low-temperature mixing device includes a refrigeration plate, an outer frame, and a reciprocating extrusion device. The reciprocating extrusion device includes a roller assembly and a rocking arm. The rocking arm includes a first rocking plate and a second rocking plate arranged oppositely. The roller assembly includes three rollers arranged vertically, and three bearings respectively passing through the three rollers. Gaskets are provided on both sides of the three rollers. The two ends of the bearings of the upper roller and the lower roller are fixedly connected to the gaskets. The two ends of the bearing of the middle roller pass through the gaskets on both sides and are respectively fixedly connected to the front ends of the first rocking plate and the second rocking plate. The rear ends of the first rocking plate and the second rocking plate are connected to a driving mechanism on the back of the outer frame, and the driving mechanism can drive the first rocking plate and the second rocking plate to make reciprocating swings around the axis.

[0011] Further, the stock solution low-temperature mixing device further includes an extrusion head assembly. The extrusion head assembly is arranged below the refrigeration plate. The extrusion head assembly includes a plurality of extrusion heads, and the plurality of extrusion heads can extend and retract relative to the outer surface of the refrigeration plate.

[0012] Further, the filling mechanism includes a peristaltic pump, an up-and-down follower filling head, and a weighing sensor. The peristaltic pump is connected to the stock solution low-temperature mixing device for conveying the stock solution to the up-and-down follower filling head. The up-and-down follower filling head is used for filling the stock solution into the vials. The weighing sensor is used for weighing the vials before and after filling.

[0013] The present invention has the following technical effects: (1) The equipment chassis is desktop type. The material sorting and feeding mechanism, filling mechanism, step-by-step track transmission mechanism, stopper and capping mechanism, capping and dust suction mechanism, discharging mechanism, and waste box are all arranged above the equipment chassis, thus forming a compact structure with a small floor area, which is convenient for movement and layout; (2) The filling, stopper and capping, and capping of the vials are all completed on a step-by-step track transmission mechanism, greatly improving the production efficiency; (3) The low-temperature mixing module is adopted to meet the requirement of low temperature during filling of raw materials; (4) The rubber stopper clamping jaws and aluminum cap clamping jaws are designed on one transplanting mechanism, effectively saving costs and space. Using one transplanting mechanism to simultaneously complete the grasping and loading of rubber stoppers and aluminum caps into the mouths of vials. It saves space, time and costs to a great extent, improves efficiency, and this design is simple and easy to implement; (5) A capping device with aluminum chip collection function is added, which does not affect the filling speed. While ensuring efficiency, it also ensures product quality, and the collection design method is simple and easy to implement; (6) The quick-change handling pawls can be customized with semi-circular grooves of different diameters to achieve filling of vials of different specifications and models. Description of the Drawings

[0014] Figure 1 is the front view of the desktop vial low-temperature filling, stopper and capping integrated machine; Figure 2This is a top view of a desktop low-temperature filling, stoppering and capping machine for vials; Figure 3 It is a schematic diagram of the structure of the material sorting and feeding mechanism; Figure 4 It is a schematic diagram of the structure of the stepping track transmission mechanism and the filling mechanism; Figure 5 It is a top view of the stepping track transmission mechanism; Figure 6 It is the structure of the stock solution low temperature mixing equipment Figure 1 ; Figure 7 It is the structure of the stock solution low temperature mixing equipment Figure 2 ; Figure 8 This is a schematic diagram of the roller running track of the stock liquid low-temperature mixing equipment; Fig. 9 is a schematic diagram of the structure of the extrusion head assembly; Fig.10 It is a schematic diagram of the plugging and capping mechanism structure; Fig.11 It is a schematic diagram of the structure of the cover-rolling dust collection mechanism; Fig.12 1. It is a schematic diagram of the structure of a rolling cap sealing device of a rolling cap dust suction structure; Fig.13 This is a schematic diagram of the dust collection device structure of the rolling cover dust collection structure Figure 1 ; Fig.14 This is a schematic diagram of the dust collection device structure of the rolling cover dust collection structure Figure 2 ; Fig.15 It is a schematic diagram of the structure of the material unloading mechanism; Fig.16 This is the operation flow chart of the desktop low-temperature filling, stoppering and capping machine for vials. DETAILED DESCRIPTION

[0015] See also Figure 1-2 The desktop type low-temperature filling, plugging and capping integrated machine for vials comprises a material sorting and feeding mechanism 2, a filling mechanism 4, a stepping track transmission mechanism 8, a plugging and capping mechanism 5, a capping and dust collection mechanism 6, a material unloading mechanism 9, a waste discharge box 13, and an equipment chassis 15. The equipment chassis 15 is desktop type, and the material sorting and feeding mechanism 2, the filling mechanism 4, the stepping track transmission mechanism 8, the plugging and capping mechanism 5, the capping and dust collection mechanism 6, the material unloading mechanism 9, and the waste discharge box 13 are all arranged above the equipment chassis 15.

[0016] See also Figure 3The material sorting and feeding mechanism 2 includes a product unpacking temporary storage table 36 and a bottle sorting rotating table 38. When in use, the wash-free and sterilization-free vials are unpacked, and the slot box is turned upside down on the product unpacking temporary storage table 36 so that the vials are open upward. After placement, the material sorting mode is started. The vials are evenly distributed on the bottle sorting rotating table 38 through the rotation of the bottle sorting rotating table 38, and the vials are sent to the stepping track transmission mechanism 8 through the material sorting rotating table 38. The bottle sorting rotating table 38 realizes rotation control through a speed regulating motor, a precision reducer and a sensor.

[0017] See also Figure 4-5 The step-by-step track transmission mechanism 8 includes a feed inspection station 3, a finished product inspection station 7, a product conveying and positioning track 42, a quick-change transport claw 43, a transport servo module 40, and an avoidance electric cylinder module 41.

[0018] The quick-change transport claw 43 is provided with a plurality of semicircular grooves matching the body of the vial 37 ; the transport servo module 40 and the avoidance electric cylinder module 41 drive the quick-change transport claw 43 to transport the vial from the material sorting and loading mechanism 2 to the product conveying positioning track 42 .

[0019] The transmission direction of the vial on the product conveying and positioning track 42 is the first direction (indicated by the X axis), and the direction perpendicular to the first direction and in the horizontal plane is the second direction (the direction from the product conveying and positioning track 42 to the transport servo module 40 / avoidance electric cylinder module 41, indicated by the Y axis). The transport servo module 40 drives the avoidance electric cylinder module 41 to move back and forth in the first direction, and the avoidance electric cylinder module 41 is fixedly connected to the quick-change transport claw 43 and moves back and forth in the second direction. The vial 37 is transported from the material sorting and loading mechanism 2 to the product conveying and positioning track 42 by the quick-change transport claw 43. The specific process is as follows: First, the material sorting and loading mechanism 2 transports the vial 37 to the semicircular groove of the quick-change transport claw 43 (the first vial station), and the quick-change transport claw 43 moves a distance ( ) in the X-axis direction under the drive of the transport servo module 40. Figure 5 As shown, the moving distance is a fixed value, which is the distance between two adjacent vials), and the vial is pushed to the next station. Then the avoidance electric cylinder module 41 drives the quick-change transport claw 43 to move a distance in the Y-axis direction (the moving distance is a fixed value, which is the radius of the vial + 5mm), so that the vial 37 is no longer in the semicircular groove of the quick-change transport claw 43. Subsequently, the quick-change transport claw 43 is driven by the transport servo module 40 to move a distance in the opposite direction of the X-axis ( Figure 5As shown, the moving distance is a fixed value, which is the distance between two adjacent vials). Finally, the avoidance electric cylinder module 41 drives the quick-change transport claw 43 to move a distance in the opposite direction of the Y axis (the moving distance is a fixed value, which is the radius of the vial + 5mm). At this time, the new vial enters the semicircular groove of the quick-change transport claw 43 again, and the vial is transferred back and forth in this way.

[0020] The quick-change transport claw 43 is a customized mold. According to the vials of different diameters to be filled, the quick-change transport claw 43 with semicircular grooves of different diameters is customized to adapt to vials of different diameters. The quick-change transport claw 43 can be easily disassembled. The quick-change transport claw 43 is connected to the avoidance electric cylinder module 41 by four mounting screws 431. The working position is positioned by positioning pins during installation. Disassembly can be completed by loosening and tightening the four mounting screws 431 without subsequent adjustments. It is convenient and efficient. This equipment meets the filling needs of vials of multiple specifications and models by replacing the quick-change transport claw 43 and adjusting the filling program, thereby realizing the function of one machine with multiple uses, saving costs, and improving the utilization rate of equipment.

[0021] At the feeding inspection station 3, a sensor detects whether there are bottles at the station and transmits the signal to the PLC control system. Later, it determines whether to fill the bottles according to the instructions of the control system. The unfilled vials or the vials with a filling accuracy greater than ±5% will enter the waste box 13. The whole filling process is automated, simple and efficient. At the finished product inspection station 7, the height of the vials after filling and capping is checked to see if they are qualified.

[0022] The filling mechanism 4 can be used to fill liquid or powdered materials. When filling powdered materials, the filling mechanism 4 includes an upper and lower follower filling head 39 and a weighing sensor. During filling, the upper and lower follower filling head 39 adds the powdered material into the vial. The weighing sensor is used to weigh the vial before and after filling, and the system records it. The vial with a filling accuracy greater than ±5% will subsequently enter the waste box 13.

[0023] When filling liquid materials, the filling mechanism 4 also includes a peristaltic pump 10. During filling, the speed of the peristaltic pump 10 is controlled according to the set filling amount, and the operation is started, and the upper and lower follower filling heads 39 add the stock liquid into the vial. The weighing sensor is used to weigh the vial before and after filling, and the system records it. The vial with a filling accuracy greater than ±5% subsequently enters the waste box 13. In the present invention, the stock liquid low-temperature mixing device 1 is used to mix the stock liquid at low temperature and then supply it to the peristaltic pump 10.

[0024] See also Figure 6-9 The stock liquid low-temperature mixing device 1 includes a roller assembly 21, a rocking arm 75, a refrigeration plate 104, an outer frame 105, a temperature detection device (not shown), and an extrusion head assembly 108.

[0025] The refrigeration plate 104 is located in the outer frame 105. The surface temperature of the refrigeration plate 104 can be set at 2-8°C according to actual needs, and the accuracy can be controlled within ±2°C. The refrigeration plate 104 adopts a conventional refrigeration method, see Figure 7 A refrigeration pipe 112 is buried in the refrigeration plate 104 and connected to a compressor 113. A heat insulation frame 111 is arranged between the refrigeration plate 104 and the outer frame 105 to block heat transfer between the refrigeration plate 104 and the outer frame 105.

[0026] The two ends of the outer frame 105 are provided with strip grooves extending up and down, and the rocking arm 75 passes through the strip grooves. The rocking arm 75 includes a first rocking plate 751 and a second rocking plate 752 arranged opposite to each other. The roller assembly 21 includes three rollers 211 arranged in the upper, middle and lower parts, and three bearings 22 respectively passing through the three rollers. Gaskets 23 are provided on both sides of the three rollers. The two ends of the bearings of the upper roller and the lower roller are fixedly connected with the gaskets 23. The two ends of the bearing of the middle roller pass through the gaskets 23 on both sides and are respectively fixedly connected with the front ends of the first rocking plate 751 and the second rocking plate 752. One end of the bearing passing through the middle roller passes through the gasket 23 and the screw hole 753 set at the front end of the first rocking plate 751, and the other end passes through the gasket 23 and the screw hole 753 set at the front end of the second rocking plate 752, and is fixed with screws respectively.

[0027] The rear ends of the first rocking plate 751 and the second rocking plate 752 are connected to a driving mechanism on the back of the outer frame 105 , and the driving mechanism can drive the first rocking plate 751 and the second rocking plate 752 to swing back and forth around the axis 754 , thereby squeezing the liquid in the liquid storage bag 101 .

[0028] During the mixing process of the cell preparation, the three rollers 211 significantly increase the contact area with the liquid storage bag 101. When the liquid volume of the liquid storage bag is large, the liquid can be fully squeezed to achieve the purpose of mixing. As the liquid in the liquid storage bag decreases, the servo motor controls the axis 754 of the rocking arm 75 to move away from the refrigeration plate 104, and then the roller assembly 21 approaches the refrigeration plate 104, repeating the reciprocating swing trajectory to complete the mixing of different volumes.

[0029] The extrusion head assembly 108 is disposed at the lower part of the refrigeration plate 104, and the extrusion head assembly 108 includes a plurality of extrusion heads 181, which can extend and retract relative to the outer surface of the refrigeration plate 104. The head of the extrusion head is made of silicone material, which will not damage the liquid storage bag.

[0030] The liquid outlet pipe 107 is arranged below the liquid storage bag 101 and connected to the peristaltic pump 10, which solves the problem of air bubbles entering the pipeline during the mixing and filling process.

[0031] The work of the stock solution low temperature mixing equipment 1 is divided into four stages: (1) Set the temperature and install the liquid storage bag 101. Set the temperature value (e.g., 4°C) through the operation panel. The compressor 113 starts running, and the temperature detection device feeds back the temperature information of the refrigeration plate 104 to the control system in real time. When the temperature reaches the set value, the mixing device is initialized on the operation panel, and the roller assembly 21 and the rocking arm 75 are away from the refrigeration plate 104, and the distance from the refrigeration plate 104 is about 80-100mm. Install the liquid storage bag 101 on the refrigeration plate 104 (e.g., hang it on the refrigeration plate with a hook). After the installation is completed, according to the initial volume of the liquid storage bag 101, set the corresponding parameters (e.g., swing start position, swing speed, retraction distance, etc.), and adjust the distance between the axis 754 of the rocking arm 75 and the refrigeration plate 104 by controlling the distance between the roller assembly 21 and the refrigeration plate 104, so that the roller assembly 21 just contacts the lower end of the liquid storage bag 101.

[0032] (2) Initial mixing. Before filling, the servo motor drives the rocking arm 75, causing the roller assembly 21 to swing back and forth relative to the axis 754 of the rocking arm 75, gradually approaching the refrigeration plate 104, squeezing the liquid in the liquid storage bag 101. After the roller assembly 21 reaches the highest point of the motion trajectory, it quickly returns to the lower end of the liquid storage bag 101, repeats the above reciprocating swing, and starts filling after mixing for 5-10 minutes.

[0033] (3) In the early stage of stock liquid filling, the servo motor drives the rocking arm 75, which is the same as the initial mixing mode, so that the roller assembly 21 swings back and forth relative to the axis 754 of the rocking arm 75, mainly relying on the roller 211 to squeeze the liquid storage bag 101. As the liquid in the liquid storage bag decreases, the servo motor controls the axis 754 of the rocking arm 75 to move away from the cooling plate 104, and then the roller 211 approaches the cooling plate 104, repeating the reciprocating swing trajectory to complete the mixing of different volumes.

[0034] The method of squeezing the liquid upward and mixing it by driving the roller 211 to roll solves the problem of cell sedimentation over time and uneven density when filling the stock liquid cell preparation. In addition, compared with mixing methods such as stirring, the shear force is small and the damage to the cells is also small.

[0035] (4) In the late stage of stock liquid filling, that is, the distance between the roller 211 and the refrigeration plate 104 is about 10-20 mm, and the extrusion head assembly 108 squeezes the liquid storage bag 101. The control system stops the movement of the roller 211 and the rocking arm 75, and the roller 211 stops at the lower end of the liquid storage bag 101, about 10-20 mm away from the refrigeration plate 104, close to the liquid storage bag 101, and plays a role in fixing the liquid storage bag 101 during the mixing process in the late stage of filling.

[0036] The control system starts the operation of the extrusion head assembly 108, driving the multiple extrusion heads 181 to extend and retract alternately, thereby squeezing the liquid storage bag 101, similar to massage, to mix the liquid in the liquid storage bag, solving the problem that other low-temperature mixing equipment on the market is difficult to mix in the later stage of filling. The extrusion head 181 is mushroom-shaped. The head of the extrusion head is made of silicone material, which will not damage the liquid storage bag.

[0037] See also Fig.10 The plugging and capping mechanism 5 includes a rubber plug vibration disk 11, an aluminum cover vibration disk 12, a rubber plug and aluminum cover transplanting mechanism 70, etc. The rubber plug and the aluminum cover are placed in the rubber plug vibration disk 11 and the aluminum cover vibration disk 12 respectively, and the motor provides power to convert it into a rotating vibration force. The vibration disk converts the input mechanical kinetic energy into the kinetic energy of the rubber plug and the aluminum cover by continuously changing the direction and amplitude of the vibration force. When the vibration disk is in a vibrating state, the rubber plug and the aluminum cover are affected by the vibration force and move up and down, left and right or in a circular direction, and are transported to the rubber plug conveying groove 66 and the aluminum cover conveying groove 67 respectively for later use.

[0038] Different from the current design form of plugging module and capping module completed separately in the market, this equipment design combines them. On the one hand, the plug discharge port 44 and the aluminum cap discharge port 65 are designed on one processing part, which effectively saves space and cost; on the other hand, the plug clamp 45 and the aluminum cap clamp 68 are designed on one transplanting mechanism, which saves one transplanting mechanism and effectively saves cost and space. One transplanting mechanism is used to simultaneously complete the grabbing and loading of the plug and the aluminum cap into the bottle mouth of the vial. It saves space, time and cost to a great extent, improves efficiency, and the design is simple and easy to implement.

[0039] First, the motor controls the rubber plug and aluminum cover transfer mechanism 70 to move to the top of the rubber plug discharge port 44 and the aluminum cover discharge port 65; then the motor controls the rubber plug and aluminum cover transfer mechanism 70 to move vertically downward, and the rubber plug clamp 45 and the aluminum cover clamp 68 are opened and closed by electric control to clamp a rubber plug and an aluminum cover respectively. After the clamping is completed, the motor controls the rubber plug and aluminum cover transfer mechanism 70 to move and transfer to the top of the stepping track conveying mechanism 8, and the rubber plug clamp 45 is aligned to the top of the vial that has been filled but not yet completed, and the aluminum cover clamp 68 is aligned to the top of the vial that has completed the plugging (for the first vial, the control system sets only the rubber plug clamp 45 to work, and the aluminum cover clamp 68 does not work. Starting from the second vial, the rubber plug clamp 45 and the aluminum cover suction clamp 68 work at the same time. For the last vial, the control system sets the rubber plug clamp 45 not to work, and only the aluminum cover clamp 68 to work.

[0040] The motor controls the rubber plug and aluminum cover transplanting mechanism 70 to move vertically downward. After the rubber plug contacts the bottle mouth of the vial and the aluminum cover contacts the rubber plug, the motor controls the clamping jaws to open. The rubber plug clamping jaws 45 and the aluminum cover clamping jaws 68 have corresponding springs to control the force of pressing the rubber plug and the aluminum cover upward and downward. The rubber plug and aluminum cover transplanting mechanism 70 is electrically controlled to press the rubber plug and the aluminum cover downward. After the action is completed, the motor controls the rubber plug and aluminum cover transplanting mechanism 70 to move to the initial position.

[0041] See also Figure 11-14 The capping dust suction mechanism 6 includes a servo lifting module 46, a guide fixing structure 50, a capping cutter head 57, a dust suction device 17, and a capping sealing device. The capping sealing device includes a stainless steel capping cover 63 and a transition joint 64. The dust suction device 17 includes a pipeline 53, a dust suction device outer cover 60, a dust suction device upper cover 62, a dust suction fan 61, and a filter element 55.

[0042] The stainless steel capping cover 63 and the transition joint 64 are fixedly connected by threads to form a cavity for accommodating the cap part of the vial. The capping cutter head 57 is located inside the cavity. The stainless steel capping cover 63 and the capping cutter head 57 can move up and down synchronously. The transition joint 64 is provided with an interface connected to the dust suction device 17, thereby connecting the dust suction device 17 with the cavity.

[0043] When in use, the vial 37 after plugging and capping completes the filling, plugging and capping process through the step-by-step conveying mechanism 8, and is pushed to the capping station, and the control system starts the capping program. The stainless steel capping cover 63 and the transition joint 64 wrap the capping cutter head 57 and move downward at the same time. The vial 37 passes through the circular hole at the lower end of the stainless steel capping cover 63, and the cap part of the vial enters the capping sealing device, and the capping cutter head 57 performs capping. The aluminum chips generated during the process are collected into the filter element 55 along the pipeline 53 by the dust suction fan 61. After the capping is completed, the stainless steel capping cover 63 and the transition joint 64 wrap the capping cutter 57 and move upward at the same time, and the cap part of the vial exits the capping sealing device. The vial 37 pushes the capped vial to the next station through the step-by-step conveying mechanism 8. The vials complete the capping process in sequence through the step-by-step track conveying mechanism 8. Since the capping process has the function of collecting aluminum chips, the problem of aluminum chips polluting the product and the environment during the capping process is solved. Therefore, the vials 37 are transported on the stepping track conveying mechanism 8, and the filling, plugging, capping and capping processes can be completed in sequence, achieving the purpose of completing the operation on the same production line, saving space and time. In addition, according to the different heights of the vials, the control system adjusts the height of the capping cutter head 57 to achieve the capping process of vials of different specifications.

[0044] Currently, there are no capping equipment with aluminum chip collection function on the market, which will cause pollution to the product and the environment during the capping process. This equipment has added an aluminum chip collection function. First, during the capping process, a sealed environment is created for the cap and the body of the vial through the stainless steel capping cover 63 and the transition joint 64, and the aluminum chips generated during the capping process are collected into the filter element 55 by the dust suction fan 61. The lifting and lowering of the stainless steel capping cover 63 and the transition joint 64 are synchronized with the lifting and lowering of the capping cutter head 57. Second, to avoid the backflow of particulate matter, the pipeline 53 is curved. Third, the filter element 55 is a consumable product with functions such as easy replacement and convenient disassembly. The capping equipment with aluminum chip collection function does not affect the filling speed. While ensuring efficiency, it also ensures product quality, and the collection design method is simple and easy to implement.

[0045] See also Fig.15 The unloading mechanism 9 includes a waste discharge electric cylinder 58, a finished product detection sensor 59, a waste discharge box 13 and a material receiving tray 71.

[0046] When in use, the capped vials are transferred to the finished product inspection station 7, and the finished product inspection sensor 59 detects the height of the vials and transmits the inspection result to the control system. If the height of the vials is not within the range set by the system, the system will identify them as unqualified products, and the unqualified products will enter the waste box 13. Qualified products are sent to the discharge track and enter the receiving tray 71. The counting function of the system determines whether the receiving tray 71 is full. The full-material shutdown alarm notifies the personnel to take away the tray and replace it with a new one. This equipment removes products with unqualified filling volume, plugging and capping, and unqualified capping before unloading, saving the cost and time of subsequent manual removal.

[0047] See also Fig.16, is the operation flow chart of the desktop low-temperature filling, plugging and capping integrated machine for penicillin bottles of the present invention. The bottle sorting rotary table 38 delivers the penicillin bottle 37 to the feeding inspection station 3. First, the feeding inspection station 3 detects whether the penicillin bottle 37 is correctly placed in the designated position. The signal is transmitted to the PLC control system, and the handling servo module 40 and the avoidance electric cylinder module 41 cooperate to transfer the penicillin bottle 37 to the next station. When the penicillin bottle 37 is transferred to the filling station, according to the detection result of the feeding inspection station 3, the control system issues instructions to the upper and lower follow-up filling heads 39 and the peristaltic pump 10, whether to fill. During filling, according to the set filling amount, the control system automatically switches to the corresponding speed of the peristaltic pump 10, starts running, and the upper and lower follow-up filling heads 39 complete the filling. The weighing sensor will record the weight of the penicillin bottle before and after filling. If the weight exceeds the set accuracy, the system will determine it as a defective product, and the penicillin bottle will eventually enter the waste box 13. The vial 37 is transferred to the next station by the cooperation of the transport servo module 40 and the avoidance electric cylinder module 41 for subsequent plugging, capping and capping processes. Finally, the finished product inspection station 7 is inspected, and qualified products are discharged, and unqualified products enter the waste box 13.

[0048] The desktop low-temperature filling, plugging and capping integrated machine for vials of the present invention has a small overall equipment size, requires a small space, and is easy to carry and debug. The filling of vials of different specifications and models can be achieved by replacing relevant mold specification parts. The operation is simple, and the function of one machine for multiple purposes is realized, which greatly improves the utilization rate of the equipment.

[0049] The low-temperature mixing module equipped with the equipment meets the needs of reagents that need to be filled under low-temperature conditions. While maintaining low temperature, cells and other preparations can be fully mixed, and the shear force is small, so as not to damage the cells. The filling module adjusts the filling program by replacing the quick-change handling claws to meet the filling needs of vials of multiple specifications and models. The filling process is automated, simple and efficient; the plugging and capping module is designed to combine the plug discharge port and the aluminum cap discharge port on a single workpiece, and the plug and aluminum cap can be grabbed and loaded (vial mouth) using a transplanting mechanism. It saves space, time and cost, and improves efficiency. The capping module is designed with an aluminum chip collection function, which can effectively collect aluminum chips in the process to avoid pollution of the product and the environment.

[0050] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A desktop low-temperature filling, plugging and capping machine for vials, comprising a material sorting and feeding mechanism (2), a filling mechanism (4), a stepping track transmission mechanism (8), a plugging and capping mechanism (5), a capping and dust collecting mechanism (6), a material unloading mechanism (9), a waste discharge box (13), and an equipment chassis (15); characterized in that: The equipment case (15) is of desktop type, and the material sorting and loading mechanism (2), the filling mechanism (4), the stepping track transmission mechanism (8), the plugging and capping mechanism (5), the capping and dust collecting mechanism (6), the unloading mechanism (9), and the waste discharge box (13) are all arranged above the equipment case (15); The material sorting and feeding mechanism (2) is used to adjust the position of the vials (37) and transmit them to the stepping track transmission mechanism (8); the filling mechanism (4) is used to fill the vials (37) on the stepping track transmission mechanism (8) with raw materials; the plugging and capping mechanism (5) is used to add rubber plugs and aluminum caps to the vials; the capping and dust suction mechanism (6) is used to cap the vials (37) and absorb aluminum scraps generated during the capping process; the unloading mechanism (9) is used to screen and collect the vials (37) that have passed the filling process, and the waste discharge box (13) is used to collect the vials (37) that have failed the filling process.

2. The all-in-one machine according to claim 1, characterized in that: The step-by-step track transmission mechanism (8) comprises a product conveying positioning track (42), a quick-change transport claw (43), a transport servo module (40), and an avoidance electric cylinder module (41); The transport servo module (40) drives the avoidance electric cylinder module (41) to move back and forth in a first direction; the avoidance electric cylinder module (41) is fixedly connected to the quick-change transport claw (43) to drive the quick-change transport claw (43) to move back and forth in a second direction; The quick-change transport claw (43) is provided with a plurality of semicircular grooves matching the body of the vial, and the vial (37) is transported from the material sorting and loading mechanism to the product conveying and positioning track (42) by the quick-change transport claw (43); The first direction is the conveying direction of the vial (37) on the product conveying and positioning track (42); the second direction is perpendicular to the first direction and parallel to the plane of the product conveying and positioning track (42).

3. The all-in-one machine according to claim 2, characterized in that: The plugging and capping mechanism (5) comprises a rubber plug vibrating plate (11), an aluminum cap vibrating plate (12), and a rubber plug and aluminum cap transplanting mechanism (70); the rubber plug vibrating plate (11) is provided with a rubber plug conveying trough (66) and a rubber plug discharging port (44); the aluminum cap vibrating plate (12) is provided with an aluminum cap conveying trough (67) and an aluminum cap discharging port (65); and the rubber plug and aluminum cap transplanting mechanism (70) is provided with a rubber plug clamping jaw (45) and an aluminum cap clamping jaw (68).

4. The all-in-one machine according to claim 3, characterized in that: The rubber plug discharge port (44) and the aluminum cover discharge port (65) are on one processed part.

5. The all-in-one machine according to claim 1, characterized in that: The capping dust suction mechanism (6) comprises a capping cutter head (57), a dust suction device (17), and a capping sealing device. The capping sealing device comprises a stainless steel capping cover (63) and a transition joint (64). The dust suction device (17) comprises a dust suction device outer cover (60), a dust suction device upper cover (62), a dust suction fan (61), and a filter element (55). The stainless steel capping cover (63) and the transition joint (64) are fixedly connected by threads to form a cavity for accommodating the cap portion of the vial. The capping cutter head (57) is located inside the cavity. The stainless steel capping cover (63) and the capping cutter head (57) can move up and down synchronously. The transition joint (64) is provided with an interface connected to the dust suction device (17), so that the dust suction device (17) is connected to the cavity.

6. The all-in-one machine according to claim 5, characterized in that: The stainless steel capping cover (63) is fixed on the capping lifting shaft. When the capping lifting shaft descends, the stainless steel capping cover (63) and the transition joint (64) wrap the capping cutter head (57) and move downward at the same time, and the cap of the vial enters the cavity. When the capping lifting shaft rises, the cap of the vial exits the cavity.

7. The all-in-one machine according to claim 6, characterized in that: When the capping cutter head (57) is in operation, the dust suction device (17) is turned on to suck aluminum scraps generated by capping into the filter element (55) through the pipeline (53).

8. The all-in-one machine according to any one of claims 1 to 7, characterized in that: The integrated machine further comprises a stock solution low temperature mixing device (1), wherein the stock solution low temperature mixing device (1) is used to mix and control the temperature of the stock solution to be filled; The raw liquid low-temperature mixing device (1) comprises a refrigeration plate (104), an outer frame (105), and a reciprocating extrusion device, wherein the reciprocating extrusion device comprises: a roller assembly (21), a rocking arm (75), the rocking arm (75) comprising a first rocking plate (751) and a second rocking plate (752) arranged opposite to each other, the roller assembly (21) comprising three rollers (211) arranged in an upper, middle and lower position, and three bearings (22) respectively passing through the three rollers, gaskets (23) being provided on both sides of the three rollers, The two ends of the bearings of the roller and the lower roller are fixedly connected to the gasket (23), and the two ends of the bearing of the middle roller pass through the gaskets (23) on both sides and are respectively fixedly connected to the front ends of the first rocking plate (751) and the second rocking plate (752); the rear ends of the first rocking plate (751) and the second rocking plate (752) are connected to a driving mechanism on the back side of the outer frame (105), and the driving mechanism can drive the first rocking plate (751) and the second rocking plate (752) to reciprocate around the axis (754).

9. The all-in-one machine according to claim 8, characterized in that: The raw liquid low-temperature mixing device (1) further comprises an extrusion head assembly (108), wherein the extrusion head assembly (108) is arranged at the lower part of the refrigeration plate (104), and the extrusion head assembly (108) comprises a plurality of extrusion heads (181), wherein the plurality of extrusion heads (181) can extend and retract relative to the outer surface of the refrigeration plate (104).

10. The all-in-one machine according to claim 8, characterized in that: The filling mechanism (4) comprises a peristaltic pump (10), an upper and lower follower filling head (39), and a weighing sensor. The peristaltic pump (10) is connected to the stock solution low-temperature mixing device (1) and is used to transfer the stock solution to the upper and lower follower filling head (39). The upper and lower follower filling head (39) is used to fill the stock solution into the vial (37). The weighing sensor is used to weigh the vial before and after filling.

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