Fungicidal composition containing famoxadone

Abstract

The invention discloses a bactericidal composition containing famoxadone, and belongs to the technical field of pesticides. The bactericidal composition containing famoxadone is prepared from the following raw materials in percentage by weight: 3 to 4 percent of famoxadone, 3 to 4 percent of hymexazol, 10 to 15 percent of aluminum sulfate, 20 to 30 percent of modified sodium bentonite, 20 to 30 percent of quaternized beta-cyclodextrin and 20 to 34 percent of water. Wherein the modified sodium bentonite is bentonite compounded and modified by sodium carbonate and a sodium lignin sulfonate, phospholipid, polyethylene glycol and nano-copper compound. The modified sodium bentonite and the quaternized beta-cyclodextrin are used as slow-release materials of the bactericidal composition, so that the stability and the slow-release performance of the bactericidal composition are improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of pesticides, and particularly relates to a bactericidal composition containing famoxadone. Background Art

[0002] The common English name of famoxadone is famoxadone, and its molecular formula is C 22 H 18 N 2 O 4 , and its chemical name is 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazoline-2,4-dione. It is a new type of highly efficient and broad-spectrum fungicide, and its mechanism of action is an energy inhibitor, that is, a mitochondrial electron transport inhibitor; it has an inhibitory effect on cytochrome C oxidoreductase in complex III. It has protective, therapeutic, eradicative, penetrative and systemic activities, and has no cross-resistance with phenylamide fungicides. Suitable crops include wheat, barley, peas, beets, rapeseed, grapes, potatoes, melons, peppers, tomatoes, fruit trees, etc. It is mainly used to control important diseases in Ascomycetes, Basidiomycetes, and Oomycetes, such as powdery mildew, rust, glume blotch, net blotch, downy mildew, late blight, etc. It has lipophilicity. After being sprayed on the crop leaves, it is easy to adhere and is not easily washed away by rain, but its use cost is high, and it is difficult to promote its large-scale application alone.

[0003] Hymexazol is a fungicide with a relatively large dosage in China at present. Its English name is Hymexazol, and its chemical name is 3-hydroxy-5-methylisoxazole, belonging to the oxazole fungicides. This agent is a highly efficient, low-toxic, environmentally friendly and broad-spectrum fungicide, and has a good control effect on plant diseases caused by various pathogenic fungi. It has good therapeutic effects on Pythium, Fusarium, Rhizoctonia, Corticium, Typhula incarnata, etc. in Oomycetes, Ascomycetes, Basidiomycetes, and Deuteromycetes. Hymexazol has systemic and conductive effects, and its bactericidal mechanism is to inhibit the mitochondrial respiration of pathogenic bacteria, but it is different from β-methoxyacrylate fungicides. At the same time, Hymexazol is also a soil disinfectant, which is highly effective against Pythium in the soil and can combine with inorganic aluminum ions in the soil to improve the ability to inhibit the germination of pathogen spores. Hymexazol is also used as a plant growth regulator. Its metabolites in plants are two glucosides, which can improve plant physiological activity, thereby promoting plant growth, root tillering, increasing root hairs and improving root activity. Hymexazol has no impact on the ecology of microorganisms in the soil and can be decomposed into compounds with very low toxicity in the soil, being safe and residue-free. However, the biodegradation rate of Hymexazol is too fast, and its bactericidal effect will be lost in a short time. Therefore, it is necessary to prepare a slow-release Hymexazol bactericidal preparation.

[0004] Patent CN106982844B describes an agricultural fungicidal composition containing famoxadone and hymexazol. This patent uses a specific slow-release agent to prepare a fungicidal slow-release agent, which is a composite slow-release agent composed of sodium bentonite and β-cyclodextrin with a weight ratio of 1:2 - 4:1, having a persistent slow-release effect and good stability. However, there is a problem of poor binding effect between sodium bentonite and β-cyclodextrin, which in turn affects the slow-release ability of the fungicidal composition. Summary of the Invention

[0005] In order to solve the problem of poor binding effect between sodium bentonite and β-cyclodextrin in the background technology, which in turn affects the slow-release ability of the fungicidal composition, the purpose of the present invention is to provide a fungicidal composition containing famoxadone.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] A fungicidal composition containing famoxadone, by weight percentage, comprises the following raw materials: 2 - 4% famoxadone, 2 - 4% hymexazol, 10 - 15% aluminum sulfate, 20 - 30% modified sodium bentonite, 20 - 30% quaternized β-cyclodextrin, 27 - 36% water; wherein the modified sodium bentonite is bentonite composite-modified by sodium carbonate and lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex.

[0008] Furthermore, the preparation method of the modified sodium bentonite is as follows:

[0009] Add an aqueous solution of sodium carbonate and an aqueous solution of lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex to bentonite, then add deionized water, mix evenly, carry out extrusion sodiumization treatment in a screw extruder, the extrusion reaction temperature is 30°C, the extrusion time is 5 minutes, and finally dry and pulverize to obtain the modified sodium bentonite.

[0010] Among them, the dosage ratio of bentonite, aqueous solution of sodium carbonate, aqueous solution of lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex, and deionized water is 10g:1mL:0.5mL:40mL; the dosage ratio of sodium carbonate and deionized water in the aqueous solution of sodium carbonate is 0.1g:1mL; the dosage ratio of lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex and water in the aqueous solution of lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex is 0.05g:0.5mL.

[0011] The interlayer substitution of calcium ions by sodium ions in montmorillonite in sodium carbonate and lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex. The lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex has a dispersing effect, which can improve the dispersibility of bentonite particles in water, making it easier to form a uniform suspension and increasing the electronegativity of bentonite.

[0012] Furthermore, the preparation method of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper composite is as follows:

[0013] Add sodium lignosulfonate and phospholipid-polyethylene glycol into deionized water, then add soluble copper salt, stir and mix at room temperature for 2 - 3 h, adjust the pH value of the solution to 10 ± 0.5 with 1 mol / L sodium hydroxide solution, then raise the temperature to 50 °C, add a reducing agent, stir and react for 2 - 3 h, dialyze, and freeze-dry to obtain sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper composite.

[0014] Among them, the dosage ratio of sodium lignosulfonate, phospholipid-polyethylene glycol, and deionized water is 3 - 4 g : 1 - 2 g : 1 L; the addition amount of soluble copper salt is 3 - 5% of the mass sum of sodium lignosulfonate and phospholipid-polyethylene glycol; the addition amount of reducing agent is 30 - 35% of the mass sum of sodium lignosulfonate and phospholipid-polyethylene glycol.

[0015] In the above steps, the soluble copper salt ionizes copper ions in water, and under the action of the reducing agent, it can reduce copper ions to copper atoms, and then form nano-copper particles. Nano-copper has antibacterial effects on a variety of pathogenic bacteria and has broad-spectrum antibacterial properties. However, nano-copper has a high specific surface area and surface energy, and it is easy to agglomerate by itself, reducing its antibacterial effect. In the present invention, sodium lignosulfonate and phospholipid-polyethylene glycol are used as dispersants and templates, which can effectively prevent the agglomeration of nano-copper. Sodium lignosulfonate contains sulfonic acid groups and phenolic hydroxyl groups, which can stabilize nano-copper particles through electrostatic repulsion and adsorption in the solution and inhibit agglomeration; the steric hindrance effect of the polyethylene glycol chain in phospholipid-polyethylene glycol can reduce particle collision and agglomeration, thereby stabilizing nano-copper particles and preventing their agglomeration. Through the synergistic effect of the above two substances, the antibacterial property of nano-copper can be significantly improved.

[0016] Furthermore, the soluble copper salt is one or a combination of more than one of copper sulfate, copper nitrate, copper chloride, and copper acetate.

[0017] Furthermore, the reducing agent is any one of hydrazine hydrate, ascorbic acid, and sodium borohydride.

[0018] Furthermore, the preparation method of quaternized β-cyclodextrin is as follows:

[0019] Add β-cyclodextrin into water and absolute ethanol, stir, then add N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, raise the temperature to 50 - 60 °C and stir for 1 - 2 h, then cool to room temperature, wash, and vacuum dry for 20 - 24 h to obtain quaternized β-cyclodextrin.

[0020] Among them, the dosage ratio of β-cyclodextrin, water, absolute ethanol, and N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride is 10 g: 10 - 20 mL: 80 - 90 mL: 0.5 - 0.9 g.

[0021] In the above steps, β-cyclodextrin contains multiple hydroxyl groups. The trimethoxysilyl group in N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride hydrolyzes to form silanol groups, and the silanol groups undergo dehydration condensation with the hydroxyl groups of β-cyclodextrin to obtain quaternized β-cyclodextrin. Quaternized β-cyclodextrin contains positive charges, and the quaternary ammonium salt group has broad-spectrum antibacterial properties, enabling β-cyclodextrin to have a bactericidal effect while carrying positive charges.

[0022] Advantages of the present invention:

[0023] 1. The present invention uses modified sodium bentonite and quaternized β-cyclodextrin as slow-release materials for the bactericidal composition. Modified sodium bentonite contains negative charges, and quaternized β-cyclodextrin contains positive charges, which can be more closely combined with each other, improving the stability and slow-release performance of the bactericidal composition.

[0024] 2. Modified sodium bentonite is prepared using sodium carbonate and lignosulfonate@phospholipid-polyethylene glycol@nano-copper composite as raw materials. Lignosulfonate@phospholipid-polyethylene glycol@nano-copper can improve the dispersibility of modified sodium bentonite, contribute to the loading of the bactericidal composition, and improve the slow-release ability of the bactericidal composition. Moreover, well-dispersed nano-copper has antibacterial properties and can act on pathogenic bacteria together with the bactericidal composition, enhancing the bactericidal effect of the bactericidal composition. And the lignosulfonate@phospholipid-polyethylene glycol@nano-copper composite contains nutrients such as S and P, enabling the bactericidal composition to promote the growth of crops while eliminating pathogenic bacteria.

[0025] 3. The quaternary ammonium salt group in quaternized β-cyclodextrin has antibacterial properties and can act on pathogenic bacteria together with the bactericidal composition, enhancing the bactericidal effect of the bactericidal composition. And quaternized β-cyclodextrin contains Si element, which can work together with nutrients such as S and P to synergistically promote crop growth. Specific embodiments

[0026] The following describes the specific embodiments of the present invention in detail, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0027] Example 1

[0028] A bactericidal composition containing oxazoxystrobin, by weight percentage, comprises the following raw materials: 2% oxazoxystrobin, 2% hymexazol, 10% aluminum sulfate, 25% modified sodium bentonite, 25% quaternized β-cyclodextrin, and 36% water.

[0029] The preparation method of the modified sodium bentonite is as follows:

[0030] Add 1 mL of sodium carbonate aqueous solution (the dosage ratio of sodium carbonate to deionized water is 0.1 g: 1 mL) and 0.5 mL of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex aqueous solution (the dosage ratio of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex to water is 0.05 g: 0.5 mL) to 10 g of bentonite, add 40 mL of deionized water, mix evenly, carry out extrusion sodiumization treatment in a screw extruder, the extrusion reaction temperature is 30 °C, the extrusion time is 5 minutes, and finally dry and pulverize to obtain the modified sodium bentonite.

[0031] The preparation method of the sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex is as follows:

[0032] Add 3 g of sodium lignosulfonate and 2 g of phospholipid-polyethylene glycol to 1 L of deionized water, then add 0.15 g of copper nitrate, stir and mix at room temperature for 23 h, adjust the pH value of the solution to 10 ± 0.5 with 1 mol / L sodium hydroxide solution, then raise the temperature to 50 °C, add 1.5 g of ascorbic acid, stir and react for 2 h, dialyze and freeze-dry to obtain the sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex.

[0033] The preparation method of the quaternized β-cyclodextrin is as follows:

[0034] Add 10 g of β-cyclodextrin to 10 mL of water and 90 mL of absolute ethanol, stir, then add 0.5 g of N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, raise the temperature to 60 °C and stir for 2 h, then cool to room temperature, wash and vacuum dry for 24 h to obtain the quaternized β-cyclodextrin.

[0035] Example 2

[0036] A bactericidal composition containing oxazolidinone includes the following raw materials by weight percentage: 3% oxazolidinone, 3% hymexazol, 12% aluminum sulfate, 25% modified sodium bentonite, 25% quaternized β-cyclodextrin, 32% water.

[0037] The preparation method of the modified sodium bentonite is as follows:

[0038] Add 1 mL of sodium carbonate aqueous solution (the dosage ratio of sodium carbonate to deionized water is 0.1 g:1 mL) and 0.5 mL of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex aqueous solution (the dosage ratio of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex to water is 0.05 g:0.5 mL) to 10 g of bentonite, add 40 mL of deionized water, mix evenly, carry out extrusion sodium modification treatment in a screw extruder, the extrusion reaction temperature is 30 °C, the extrusion time is 5 minutes, and finally dry and pulverize to obtain modified sodium-based bentonite.

[0039] The preparation method of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex is as follows:

[0040] Add 4 g of sodium lignosulfonate and 1 g of phospholipid-polyethylene glycol to 1 L of deionized water, then add 0.2 g of copper nitrate, stir and mix at room temperature for 2 h, adjust the pH value of the solution to 10 ± 0.5 with 1 mol / L sodium hydroxide solution, then heat up to 50 °C, add 1.6 g of ascorbic acid, stir and react for 2 h, dialyze and freeze-dry to obtain sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex.

[0041] The preparation method of quaternized β-cyclodextrin is as follows:

[0042] Add 10 g of β-cyclodextrin to 10 mL of water and 90 mL of absolute ethanol, stir, then add 0.7 g of N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, heat up to 60 °C and stir for 2 h, then cool to room temperature, wash and vacuum dry for 24 h to obtain quaternized β-cyclodextrin.

[0043] Example 3

[0044] A bactericidal composition containing oxazolinone, by weight percentage, comprises the following raw materials: 4% oxazolinone, 4% hymexazol, 15% aluminum sulfate, 25% modified sodium-based bentonite, 25% quaternized β-cyclodextrin, 27% water.

[0045] The preparation method of modified sodium-based bentonite is as follows:

[0046] Add 1 mL of sodium carbonate aqueous solution (the dosage ratio of sodium carbonate to deionized water is 0.1 g:1 mL) and 0.5 mL of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex aqueous solution (the dosage ratio of sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex to water is 0.05 g:0.5 mL) to 10 g of bentonite, add 40 mL of deionized water, mix evenly, carry out extrusion sodium modification treatment in a screw extruder, the extrusion reaction temperature is 30 °C, the extrusion time is 5 minutes, and finally dry and pulverize to obtain modified sodium-based bentonite.

[0047] The preparation method of sodium lignosulfonate@phospholipid-polyethylene glycol@nano copper complex is as follows:

[0048] Add 4 g of sodium lignosulfonate and 1 g of phospholipid-polyethylene glycol into 1 L of deionized water, then add 0.25 g of copper nitrate, stir and mix at room temperature for 2 h, adjust the pH value of the solution to 10±0.5 with 1 mol / L sodium hydroxide solution, then heat up to 50 °C, add 1.75 g of ascorbic acid, stir and react for 2 h, dialyze, and freeze-dry to obtain sodium lignosulfonate@phospholipid-polyethylene glycol@nano copper complex.

[0049] The preparation method of quaternized β-cyclodextrin is as follows:

[0050] Add 10 g of β-cyclodextrin into 10 mL of water and 90 mL of absolute ethanol, stir, then add 0.9 g of N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, heat up to 60 °C and stir for 2 h, then cool to room temperature, wash, and vacuum dry for 24 h to obtain quaternized β-cyclodextrin.

[0051] Example 4

[0052] The difference between this example and Example 1 is that:

[0053] Replace "0.15 g of copper nitrate" in Example 1 with "0.1 g of copper nitrate", and the other raw materials and steps are the same as those in Example 1.

[0054] Example 5

[0055] The difference between this example and Example 3 is that:

[0056] Replace "0.25 g of copper nitrate" in Example 3 with "0.3 g of copper nitrate", and the other raw materials and steps are the same as those in Example 3.

[0057] The other raw materials and steps are the same as those in Example 3.

[0058] Comparative Example 1

[0059] The difference between this comparative example and Example 1 is that:

[0060] The preparation method of modified sodium bentonite is as follows:

[0061] Add 1 mL of sodium carbonate aqueous solution (the dosage ratio of sodium carbonate to deionized water is 0.1 g:1 mL) and 0.5 mL of sodium lignosulfonate@nano-copper composite aqueous solution (the dosage ratio of sodium lignosulfonate@nano-copper composite to water is 0.05 g:0.5 mL) to 10 g of bentonite, then add 40 mL of deionized water, mix evenly, carry out extrusion sodiumization treatment in a screw extruder, the extrusion reaction temperature is 30 °C, the extrusion time is 5 minutes, and finally dry and pulverize to obtain modified sodium-based bentonite.

[0062] The preparation method of sodium lignosulfonate@nano-copper composite is as follows:

[0063] Add 5 g of sodium lignosulfonate to 1 L of deionized water, then add 0.15 g of copper nitrate, stir and mix at room temperature for 23 h, adjust the pH value of the solution to 10 ± 0.5 with 1 mol / L sodium hydroxide solution, then raise the temperature to 50 °C, add 1.5 g of ascorbic acid, stir and react for 2 h, dialyze, and freeze-dry to obtain sodium lignosulfonate@nano-copper composite.

[0064] The remaining raw materials and steps are the same as those in Example 1.

[0065] Comparative Example 2

[0066] The difference between this comparative example and Example 1 is that:

[0067] β-cyclodextrin is not subjected to quaternization treatment, and the remaining raw materials and steps are the same as those in Example 1.

[0068] Comparative Example 3

[0069] The difference between this comparative example and Example 1 is that:

[0070] The preparation method of sodium-based bentonite is as follows:

[0071] Add 1.5 mL of sodium carbonate aqueous solution (the dosage ratio of sodium carbonate to deionized water is 0.1 g:1 mL) to 10 g of bentonite, then add 40 mL of deionized water, mix evenly, carry out extrusion sodiumization treatment in a screw extruder, the extrusion reaction temperature is 30 °C, the extrusion time is 5 minutes, and finally dry and pulverize to obtain sodium-based bentonite.

[0072] The remaining raw materials and steps are the same as those in Example 1.

[0073] Comparative Example 4

[0074] The difference between this comparative example and Example 1 is that:

[0075] β-cyclodextrin is not subjected to quaternization treatment, and the modified sodium-based bentonite is the sodium-based bentonite prepared in Comparative Example 3, and the remaining raw materials and steps are the same as those in Example 1.

[0076] The corresponding weight percentages of oxadone, oxadone and aluminum sulfate of Examples 1 to 5 and Comparative Examples 1 to 3 were added to water and stirred evenly, and then modified sodium bentonite and quaternized β-cyclodextrin were added, and the mixture was stirred evenly to fully blend the mixture into a paste colloid to prepare the sample to be tested. The sample was tested for performance, and the test items were as follows:

[0077] The experimental crop was cucumber, and the control target was cucumber downy mildew (Pseudoperonospora cubens is). Field efficacy tests were conducted. The plots of experimental agents, control agents, and blank controls were arranged in random blocks, with a plot area of ​​30m 2 , repeated 4 times. Investigate the disease base before applying the pesticide, apply the pesticide once, 45kg of liquid per mu, investigate the control effect 10d and 15d after applying the pesticide, and investigate 4 times in total. Randomly select four points in each plot for investigation, investigate two plants at each point, investigate all leaves of each plant, and classify and record each leaf according to the percentage of disease spots to leaf area. Classification method (based on leaves):

[0078] Level 0: no lesions;

[0079] Level 1: The lesion area accounts for less than 5% of the entire leaf area;

[0080] Level 3: The lesion area accounts for 6%-10% of the entire leaf area;

[0081] Level 5: The lesion area accounts for 11%-25% of the entire leaf area;

[0082] Level 7: The lesion area accounts for 26%-50% of the entire leaf area;

[0083] Level 9: The lesion area accounts for more than 50% of the total leaf area.

[0084] Disease index = [∑ (number of diseased leaves at each level × relative level value) / (total number of leaves surveyed × 9)] × 100; control effect (%) = [1-(disease index of control before application × disease index of treatment after application) / (disease index of control after application × disease index of treatment before application) × 100

[0085] Table 1

[0086] Project Disease index before treatment Control efficacy 10 days after treatment / % Control efficacy 15 days after treatment / % Example 1 7.83 98.12 96.87 Example 2 7.57 98.34 97.13 Example 3 7.49 98.59 97.44 Example 4 7.38 98.07 96.83 Example 5 7.51 98.54 97.34 Comparative example 1 7.48 97.83 96.33 Comparative example 2 7.91 97.74 95.38 Comparative example 3 7.53 97.52 95.03 Comparative example 4 7.46 96.35 92.86 Blank control 7.72 / /

[0087] As can be seen from Table 1, the bactericidal performance and sustained-release performance of the bactericidal compositions of Examples 1 to 5 are better than those of Comparative Examples 1 to 3. The performances of Examples 4 and 5 are lower than those of Examples 1 and 3, respectively, indicating that excessive or insufficient addition of copper nitrate will affect the bactericidal performance of the bactericidal composition, and the addition amount of copper nitrate of the present invention is the optimal amount.

[0088] In Comparative Example 1, the modified sodium bentonite does not contain phospholipid-polyethylene glycol, and its bactericidal performance is lower than that of Example 1. The reason is that: in phospholipid-polyethylene glycol, the steric hindrance effect of the polyethylene glycol chain reduces particle collision and aggregation, thereby stabilizing the nano-copper particles and preventing their aggregation. Furthermore, the antibacterial property of the bactericidal composition is improved.

[0089] In Comparative Example 2, the surface of β-cyclodextrin does not contain quaternary ammonium salt groups, and its sustained-release performance and bactericidal performance are both lower than those of Example 1. The reason is that: the quaternary ammonium salt groups in quaternized β-cyclodextrin have antibacterial properties and can act on pathogenic bacteria together with the bactericidal composition, enhancing the bactericidal effect of the bactericidal composition. Moreover, the modified sodium bentonite has a negative charge, and quaternized β-cyclodextrin has a positive charge, and the two can be more closely combined, improving the stability and sustained-release performance of the bactericidal composition.

[0090] In Comparative Example 3, the sodium bentonite does not contain sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper, and its sustained-release performance and bactericidal performance are both lower than those of Example 1. The reason is that: the sodium lignosulfonate@phospholipid-polyethylene glycol@nano-copper complex has a dispersing effect, can improve the dispersibility of bentonite particles in water, helps the loading of the bactericidal composition, and improves the sustained-release ability of the bactericidal composition.

[0091] In Comparative Example 4, neither the sodium bentonite nor the cyclodextrin is modified, and the sustained-release performance and bactericidal performance are the worst.

[0092] The above only discloses several specific embodiments of the present invention. However, the embodiments of the present invention are not limited thereto, and any changes that can be thought of by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A bactericidal composition containing famoxadone, characterized in that: The raw materials include the following by weight percentage: 3-4% oxadone, 3-4% oxadipate, 10-15% aluminum sulfate, 20-30% modified sodium bentonite, 20-30% quaternized beta-cyclodextrin, and 20-34% water; wherein the modified sodium bentonite is a bentonite compositely modified by sodium carbonate and sodium lignin sulfonate@phospholipid-polyethylene glycol@nano copper complex.

2. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The preparation method of modified sodium bentonite is: Sodium carbonate aqueous solution and sodium lignin sulfonate @ phospholipid-polyethylene glycol @ nano copper complex aqueous solution are added to bentonite, and then deionized water is added, mixed evenly, and extruded in a screw extruder for sodium treatment. The extrusion reaction temperature is 30°C, the extrusion time is 5 minutes, and finally dried and crushed to obtain modified sodium-based bentonite.

3. A bactericidal composition containing famoxadone according to claim 2, characterized in that: The dosage ratio of bentonite, sodium carbonate aqueous solution, sodium lignin sulfonate@phospholipid-polyethylene glycol@nano-copper complex aqueous solution, and deionized water is 10g:1mL:0.5mL:40mL; the dosage ratio of sodium carbonate to deionized water in the sodium carbonate aqueous solution is 0.1g:1mL; the dosage ratio of sodium lignin sulfonate@phospholipid-polyethylene glycol@nano-copper complex to water in the sodium lignin sulfonate@phospholipid-polyethylene glycol@nano-copper complex aqueous solution is 0.05g:0.5mL.

4. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The preparation method of sodium lignin sulfonate@phospholipid-polyethylene glycol@nano copper complex is as follows: Sodium lignin sulfonate and phospholipid-polyethylene glycol are added to deionized water, and then a soluble copper salt is added, and the mixture is stirred and mixed at room temperature for 2-3 hours. The pH value of the solution is adjusted to 10±0.5 with 1 mol / L sodium hydroxide solution, and then the temperature is raised to 50°C, a reducing agent is added, and the mixture is stirred and reacted for 2-3 hours. The mixture is dialyzed and freeze-dried to obtain a sodium lignin sulfonate@phospholipid-polyethylene glycol@nano copper complex.

5. A bactericidal composition containing famoxadone according to claim 4, characterized in that: The dosage ratio of sodium lignin sulfonate, phospholipid-polyethylene glycol and deionized water is 3-4g:1-2g:1L.

6. A bactericidal composition containing famoxadone according to claim 4, characterized in that: The added amount of the soluble copper salt is 3-5% of the total mass of the sodium lignin sulfonate and the phospholipid-polyethylene glycol.

7. A bactericidal composition containing famoxadone according to claim 4, characterized in that: The amount of the reducing agent added is 30-35% of the total mass of sodium lignin sulfonate and phospholipid-polyethylene glycol.

8. A bactericidal composition containing famoxadone according to claim 4, characterized in that: The soluble copper salt is a combination of one or more of copper sulfate, copper nitrate, copper chloride and copper acetate.

9. A bactericidal composition containing famoxadone according to claim 4, characterized in that: The reducing agent is any one of hydrazine hydrate, ascorbic acid and sodium borohydride.

10. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The preparation method of quaternized β-cyclodextrin is: Add β-cyclodextrin to water and anhydrous ethanol, stir, then add N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride, heat to 50-60° C. and stir for 1-2 hours, then cool to room temperature, wash, and vacuum dry for 20-24 hours to obtain quaternized β-cyclodextrin; The dosage ratio of β-cyclodextrin, water, anhydrous ethanol and N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride is 10g: 10-20mL: 80-90mL: 0.5-0.9g.