Sampling and detecting integrated device and sampler thereof

Abstract

The invention belongs to the technical field of sampling and testing equipment, and particularly relates to a sampling and detection integrated device and a sampler thereof, and the sampling and detection integrated device comprises the sampler, a solution pipe, a detection pipe and a base; openings are formed in the two ends of the detection tube, and the diameter of the detection tube is gradually increased from the top to the bottom; the sampler comprises a holding part, a combining part, a sampling rod and a collecting part which are sequentially connected from top to bottom, the interior of the collecting part is hollowed out to form a mounting space, at least one partition plate is arranged in the mounting space in the width direction of the collecting part, the mounting space is divided into at least two containing cavities by the at least one partition plate, and the containing cavities are communicated with the holding part. Through the structure, the invention comprehensively provides the self-testing device which is used for stably collecting samples in various forms and is prevented from toppling over.

Description

Technical Field

[0001] The invention belongs to the technical field of sampling and testing equipment, and specifically relates to a sampling and testing integrated device and a sampler thereof. Background Art

[0002] The sample types of conventional medical examinations (including human and animal medicine) mainly include blood, urine, feces, saliva, vaginal secretions, etc. Among them, fecal testing is a non-invasive detection method that is simple and easy to obtain. During the fecal testing process, it is usually necessary to use a collection spoon / sampling stick to collect feces, and then put the collection spoon / stick after collecting the sample into a matching disposable storage tube and seal it for subsequent testing operations.

[0003] For example, a Chinese invention patent with application number 2017103195448 discloses an independent stool sampling head, which includes a main body, the main body having a spike portion and a brush portion, one end of the spike portion is a pointed structure, and the other end of the spike portion is connected to one end of the brush portion; the brush portion has bristles in the circumference, and a storage area is formed between the bristles and the other end of the spike portion, which serves as a place to store collected samples.

[0004] The above-mentioned sampling head can basically realize sample collection. However, for samples with different properties, including liquid, solid and viscous samples, the above-mentioned sampling head is difficult to guarantee the sampling volume. Moreover, especially for feces, its collection, preservation and transportation requirements are relatively high. Some detection indicators are less stable in feces and need to be collected freshly. However, people who go to the hospital for physical examinations have no urge to defecate or it is not easy to defecate in the hospital environment, which makes the coverage and participation rates of many tests not high, and they cannot be detected in time, which may delay the progress of the disease.

[0005] To this end, the Chinese invention patent with publication number CN117129671A discloses an integrated device for collecting and detecting feces samples, which includes a detection bottle and a sampling rod; the detection bottle is a three-layer sleeve structure connected by a card slot, from the inside to the outside, respectively, a sample processing liquid bottle, a test paper holder and an outer bottle; for another example, the Chinese utility model patent with publication number CN220795049U discloses an integrated detection tube, including: a sampling rod, the sampling rod includes a hand-held portion for holding and a sampling tube for sampling, and the hand-held portion is connected to the sampling tube; a container tube, the container tube is open at both ends and hollow inside, and the sampling tube of the sampling rod is embedded in the container tube; a collecting chamber, a guide groove is provided in the collecting chamber, and the container tube is at least partially embedded in the collecting chamber; wherein an aluminum foil is provided at the opening of one end of the container tube away from the hand-held portion.

[0006] The above-mentioned devices are all composed of multiple straight tube components "nested layer by layer" from top to bottom, and their stability is difficult to ensure. In order to prevent tipping, the existing technology usually increases its stability by additionally setting independent auxiliary components, such as setting a counterweight structure, a clamping structure, an adsorption device, etc. However, the above method will inevitably increase the complexity of the equipment.

[0007] Therefore, there is an urgent need for a sampling and detection device with a simple structure, good sampling effect, and both stability and sealing. Summary of the invention

[0008] The object of the present invention is to provide a sampling and detection integrated device and a sampler thereof, so as to partially alleviate or solve the above-mentioned problems.

[0009] In order to solve the above-mentioned technical problems, the present invention specifically adopts the following technical solutions: The present application provides a sampling and detection integrated device, comprising: a sampler, a solution tube, a detection and base; both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from the top to the bottom, at least a part of the solution tube is sleeved in the detection tube, at least a part of the sampler is sleeved in the solution tube, and the base cooperates with the opening at the bottom of the detection tube; The base includes a bottom cover, and an enclosure and a puncture portion arranged on the bottom cover, the outer wall of the enclosure is in contact with the inner wall of the detection tube, the puncture portion is located in the enclosure space formed by the enclosure, the inner diameter of the top of the enclosure decreases from top to bottom, so that the top of the enclosure forms a transition slope; a groove is arranged on one side of the enclosure, a detection space for accommodating a test strip is arranged on the detection tube, and an opening connected to the groove is arranged at the bottom of the detection space, so that the first end of the test strip can extend from the opening and pass through the groove into the enclosure space.

[0010] As an improvement, the enclosure includes a first baffle and a second baffle arranged in sequence from the outside to the inside, the height of the second baffle is lower than the height of the first baffle, the first end of the first baffle is connected to the first end of the second baffle through a third baffle, and the transition slope is formed on the first surface of the third baffle; the outer wall of the first baffle is in contact with the inner wall of the detection tube; the first baffle, the second baffle, the third baffle and the bottom cover are enclosed to form a cavity.

[0011] As an improvement, the side of the enclosure close to the opening is recessed downward along its height direction to form the slot, and the parts of the enclosure located on both sides of the slot are respectively recessed inward to form slots connected to the enclosure space, and the slots are arranged along the height direction of the enclosure; When the first end of the test strip is extended from the opening, and the first end of the test strip is extended into the enclosed space along the slot, both sides of the first end of the test strip are locked into the slot and fixed.

[0012] As an improvement, the solution tube includes an integrally formed bottom plate and a tube body, the bottom plate is arranged at the bottom of the tube body, and an opening cooperating with the sampler is arranged at the top of the solution tube; a puncture groove cooperating with the tip of the puncture part is arranged on the bottom plate, and the thickness of the puncture groove is less than the thickness of the bottom plate.

[0013] As an improvement, a scraping structure is provided inside the solution tube, and the scraping structure includes a solution exchange area, a collection area and a scraping area arranged in sequence from top to bottom, the solution exchange area is provided with at least one exchange hole, and the scraping area is provided with at least two scraping protrusions, and a scraping groove is formed between two adjacent scraping protrusions; The inner diameters of the exchange area and the collection area decrease gradually from top to bottom, and the inner diameter of the scraping area is the same along the height direction of the solution tube, so that the scraping structure is funnel-shaped.

[0014] The present application also provides a sampler, comprising: a holding portion, a combining portion, a sampling rod and a collecting portion connected in sequence from top to bottom, the interior of the collecting portion being hollowed out to form an installation space, at least one partition is arranged in the installation space along the width direction of the collecting portion, and the at least one partition divides the installation space into at least two accommodating cavities; a pointed structure is arranged at the first end of the collecting portion, the pointed structure comprises a first surface, a second surface, a third surface and a fourth surface connected in sequence, the first surface, the second surface, the third surface and the fourth surface are arranged circumferentially along the pointed structure; wherein the first surface and the third surface are respectively recessed inwards to form a guide area with a first inclination.

[0015] As an improvement, the partition is provided with a plurality of anti-slip protrusions and / or a plurality of recessed portions, and adjacent anti-slip protrusions cooperate with the partition to form a limiting structure, thereby dividing the accommodating cavity into a plurality of accommodating areas.

[0016] As an improvement, a plurality of partitions are provided, and the plurality of partitions are evenly arranged in the installation space, so that the heights of the plurality of accommodating cavities are the same.

[0017] As an improvement, a plurality of partitions are provided, and the plurality of partitions are non-uniformly arranged in the installation space to form a plurality of accommodating cavities with different heights.

[0018] As an improvement, the second end of the installation space extends toward the second end of the collecting portion to form a transition zone with a second inclination.

[0019] The principle and beneficial technical effects of the present invention are: Completely different from the prior art method of using multiple straight tube components to be "nested" from top to bottom, the present application provides a semi-wrapped anti-dumping device that is built into a test strip and installed from bottom to top. The stability of the device with the above structure is greatly improved, and it has a simple structure and is easy to install.

[0020] First of all, the present application can prevent tipping over to a great extent by concentrating the center of gravity of the self-test device at the bottom of the device. Moreover, the test strip located in the detection tube is directly introduced into the enclosure space during the installation process and is in direct contact with the solution containing the sample dissolved in the enclosure space, and the solution does not need to enter the detection tube or the gap between the detection tube and the enclosure. In other words, when no tipping occurs, the solution is always located in the enclosure space, thereby preventing the solution from leaking from the gap between the detection tube and the enclosure. Specifically, the base and the detection tube in the present application both adopt a truncated cone design, and the base cooperates with the detection tube through an opening at the bottom of the detection tube. It adopts a "bottom-to-top" installation method, and the installed base is located in the lower half of the detection tube, which is quick and easy to install. That is, the present application provides an integrated sampling and detection device that is easy to install and has greatly improved stability while preventing leakage.

[0021] Furthermore, even if tipping occurs, the enclosure is set close to the inner wall of the detection tube, and a transition slope is set on the top of the enclosure, and it is further sealed by a limiting structure at its bottom, so it is difficult for the solution to leak out of the detection tube. After the self-test device is straightened, the solution above the enclosure can quickly flow back to the enclosure space under the drainage action of the transition slope, further avoiding leakage.

[0022] Furthermore, for samples of different volumes / quantities, the present application provides a solution that enables the samples to be "quantitatively" dissolved into the solution. Specifically, by adjusting the height of the scraping structure, excess samples are excluded from the solution, and smaller sample volumes can be dissolved in the solution as much as possible. That is, whether it is a larger sample (such as feces) or a smaller sample in quantity and / or volume (such as a virus), the present device can stably collect and detect it, thereby ensuring the reliability of the test results.

[0023] In addition, in response to the sampling needs of samples of different forms, the present application comprehensively provides a sampler with a "guided semi-closed containing chamber". By arranging multiple "semi-closed" containing chambers in the collecting part and arranging guiding structures on both sides of the collecting part, samples of different forms can be collected and stably stored, and the problem of samples falling from the sampler can be prevented to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, each element or part is not necessarily drawn according to the actual scale. Obviously, the drawings described below are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without paying creative labor.

[0025] Figure 1 It is a three-dimensional diagram of the sampling and detection integrated device in the initial state according to the embodiment of the present invention; Figure 2 It is a stereoscopic diagram of the sampling and detection integrated device in the detection state according to the embodiment of the present invention; Figure 3 An exploded view of the sampling and detection integrated device in an embodiment of the present invention; Figure 4 It is a cross-sectional view of the sampling and detection integrated device in the initial state according to the embodiment of the present invention; Figure 5 This is an enlarged schematic diagram of part B of the sampling and detection integrated device in an embodiment of the present invention; Figure 6 It is a cross-sectional view at another angle of the initial state of the integrated sampling and detection device in the embodiment of the present invention; Figure 7 A cross-sectional view of the sampling and detection integrated device in the embodiment of the present invention when sampling; Figure 8 It is a cross-sectional view of the sampling and detection integrated device according to the embodiment of the present invention after sampling, in which the sampler is inserted back into the solution tube; Fig. 9 It is a cross-sectional view of the integrated sampling and detection device in the embodiment of the present invention after the limiting piece is removed; Fig.10 It is a cross-sectional view of the sampling and detection integrated device in the embodiment of the present invention during the detection process after the solution tube and the sampler are pressed down; Fig.11 is a three-dimensional diagram of a base in an embodiment of the present invention; Fig.12 is a front view of a sampler in an embodiment of the present invention; Fig.13 is a side view of a sampler in an embodiment of the present invention; Fig.14 A three-dimensional diagram of a sampler in an embodiment of the present invention; Fig.15 for Fig.12 A magnified schematic diagram of part A; Fig.16is an example of the size of the sampler in the embodiment of the present invention; Fig.17 is an example of the size of the sampler in the embodiment of the present invention; Fig.18 A three-dimensional diagram of a solution tube in an embodiment of the present invention; Fig.19 is a top view of a partition in an embodiment of the present invention; Fig. 20 Schematic diagram of a detection tube in an embodiment of the present invention; Fig.21 is a schematic diagram of a sampling rod in a fourth embodiment of the present invention; Fig. 22 Schematic diagram of the upper cover in the fourth embodiment of the present invention; Fig.23 It is a schematic diagram of the scraping structure in the fifth embodiment of the present invention; Fig.24 It is a cross-sectional view of the integrated sampling and detection device in the fifth embodiment of the present invention when it is in an initial state; Fig.25 This is a cross-sectional view of the integrated sampling and detection device in Example 5 of the present invention when sampling; Fig.26 It is a cross-sectional view of the scraping structure in the fifth embodiment of the present invention when it is located above the liquid surface; Fig. 27 It is a schematic diagram of another form of scraping-like structure in the fifth embodiment of the present invention.

[0026] Markings in the figure: 1. sampler; 11. gripping part; 111. anti-skid groove; 12. joint part; 13. sampling rod; 131. first groove; 132. second groove; 14. collecting part; 141. pointed structure; 142. guide area; 143. transition area; 144. partition; 401. anti-skid protrusion; 402. containing area; 145. containing cavity; 2. solution tube; 21. bottom plate; 211. puncture groove; 22. tube body; 23. guide part; 24. anti-skid strip; 25. storage tank; 26. solution; 3. Detection tube; 31. Detection space; 32. Opening; 33. Test strip installation slot; 34. Limiting step; 4. Base; 41. Bottom cover; 42. Enclosure; 421. First baffle; 422. Second baffle; 423. Third baffle; 424. Cavity; 425. Slot; 43. Puncture portion; 44. Transition slope; 45. Slot; 46. Enclosure space; 47. Limiting protrusion; 5. Limiting member; 6. Test strip; 7. Fixing member; 71. Display hole; 8. Protection plate; 9. Sealing ring; 10. Upper cover; 20. Scraping structure; 201. Solution exchange area; 202. Collection area; 203. Scraping area; 204. Scraping protrusion; 205. Scraping groove; 206. Exchange hole; 207. Support portion; 208. Through hole. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0028] Herein, the suffixes such as "module", "component" or "unit" used to represent elements are used only to facilitate the description of the present invention and have no specific meaning in themselves. Therefore, "module", "component" or "unit" can be used in a mixed manner. Herein, the orientation or positional relationship indicated by the terms "upper", "lower", "inner", "outer", "front", "back", "one end", "the other end", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0029] In this document, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium, or it can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In this document, "plurality" means two or more, that is, it includes two, three, four, five, etc.

[0030] Embodiment 1 This embodiment is basically as shown in the attached Figure 12-Figure 17 and Fig.19 As shown: This embodiment provides a sampler, see Fig.12 and Fig.13 , including a holding portion 11, a combining portion 12, a sampling rod 13 and a collecting portion 14 which are sequentially connected from top to bottom.

[0031] See also Fig.15The interior of the collecting part is hollowed out to form an installation space, and at least one partition 144 is arranged in the installation space along the width direction of the collecting part, and the at least one partition 144 divides the installation space into at least two accommodating cavities 145; a pointed structure 141 is provided at the first end of the collecting part, and the pointed structure 141 includes a first surface, a second surface, a third surface and a fourth surface connected in sequence, and the first surface, the second surface, the third surface and the fourth surface are arranged circumferentially along the pointed structure 141; wherein the first surface and the third surface are respectively recessed inward to form a guide area 142 with a first inclination.

[0032] In some embodiments, the first surface and the third surface are arranged opposite to each other, and the second surface and the fourth surface are arranged opposite to each other, that is, two sides of the pointed structure form a bevel shape after cutting (i.e., the guide area 142), so that the width of the pointed structure increases from bottom to top, and then smoothly transitions with the installation space, so that when the sampler is inserted into the sample, the sample can enter the accommodating cavity along the guide area.

[0033] In some embodiments, the middle portion of the cross section of the installation space is a rectangle, and two width sides of the rectangle extend toward both ends to form an arc shape.

[0034] In some embodiments, the tip portion of the pointed structure is blunt.

[0035] See also Fig.19 The partition is provided with a plurality of anti-skid protrusions 401 and / or a plurality of recessed portions, and the adjacent anti-skid protrusions 401 cooperate with the partition to form a limiting structure, thereby dividing the receiving cavity into a plurality of receiving areas 402. Through the cooperation between the anti-skid protrusions and the surface of the partition, when the sample enters the receiving area, the cooperation between the adjacent anti-skid protrusions limits the sample in the width direction (radial direction), and the two adjacent partitions limit the sample in the height direction, so that the sample can be stably stored inside the receiving area.

[0036] In some embodiments, a plurality of partitions are provided, and the plurality of partitions are evenly arranged in the installation space, so that the heights of the plurality of accommodating cavities are the same.

[0037] In some other embodiments, a plurality of partitions are provided, and the plurality of partitions are non-uniformly arranged in the installation space to form a plurality of accommodating cavities with different heights.

[0038] In some embodiments, the partition is a circular partition, the sampling rod is cylindrical, and the diameter of the partition is smaller than or equal to the diameter of the sampling rod.

[0039] In some embodiments, the second end of the installation space extends toward the second end of the collecting portion to form a transition zone 143 having a second inclination.

[0040] In some embodiments, two of the guide area and the transition area 143 are provided, and are symmetrical about the central axis of the sampling rod.

[0041] In some embodiments, see Fig.14 The sampling rod is circumferentially provided with a first groove 131 and a second groove 132 , and sealing rings are provided in the first groove 131 and the second groove 132 .

[0042] In some embodiments, see Fig.14 The gripping portion is spherical, and the inner diameter of the gripping portion gradually increases and then decreases from the first end to the second end, and a plurality of anti-slip grooves 111 are circumferentially arranged on the gripping portion.

[0043] In some specific embodiments, the anti-slip grooves are multiple grooves formed by the surface of the spherical gripping portion being recessed inwardly along the width direction.

[0044] In some embodiments, the plurality of grooves are evenly distributed on the spherical gripping portion.

[0045] By providing a spherical grip, it is convenient for the user to apply force when pressing the grip and pulling the sampler out of the self-test device. In addition, the grip adopts a hollow structure (anti-slip groove), which can save production costs on the one hand, and reduce the weight of the grip on the other hand, thereby preventing the sampler from becoming "top-heavy" and tipping over when cooperating with the self-test device.

[0046] In some embodiments, the volume of the installation space is 50mm 3 -200mm 3 (Preferably 73mm 3 ).

[0047] For example, see Fig.16 and Fig.17 The figure gives an example of a sampler. Specifically, the total length of the sampler is 90.1 mm, the width of the joint is 15 mm, the height of the holding part and the joint is 37.7 mm, the height of the collecting part is 18.3 mm, the height of the installation space is 11.8 mm, the number of accommodating cavities is 6, of which 5 accommodating cavities have a height of 1.1 mm and the height of the other accommodating cavity is 2.25 mm; the width of the sampling rod is 3.9 mm, and the width of the collecting part is 3.7 mm.

[0048] In summary, the present application arranges multiple "semi-closed" containing cavities in the collecting part and arranges guiding structures on both sides of the collecting part, so as to collect and stably store samples of different forms and prevent the problem of samples falling from the sampler to a certain extent.

[0049] First, the accommodating chamber in the present application is formed by the inner wall of the installation space (i.e., the side wall of the collecting part) and the partition. When in use, the two side walls of the collecting part can limit the sample in the accommodating chamber in the width direction, and the two adjacent partitions, or a partition and the bottom wall or top wall of the installation space, can limit the sample in the accommodating chamber in the height direction, so that the sample is in a "semi-closed" space, and the sampler always remains upright after sampling and during the insertion of the self-test device. In this way, the sample can be simultaneously limited in the width and height directions through the above-mentioned structure, which can effectively prevent the sample from falling out of the accommodating chamber.

[0050] Furthermore, "guide structures" are respectively provided on both sides of the collecting portion, so that the sampler can collect as many samples as possible during the process of inserting and removing the sample; specifically, a guide area is provided on the pointed structure located at the first end of the collecting portion, and during the process of inserting the sampler into the sample, the sample can enter the accommodating cavity along the guide area, and during the process of removing the sampler from the sample, due to the resistance of the sample, the sample located above the accommodating cavity can enter the accommodating cavity along the transition area.

[0051] Furthermore, for different samples, evenly or unevenly arranged partitions can be selected respectively. For example, for watery feces, evenly arranged partitions can be selected, so that the samples can enter the receiving cavity evenly. Furthermore, the density of the partitions can be increased, that is, the intervals between the partitions can be reduced, so that the height of the receiving cavity is lower and it is easier to store samples. For solid feces, unevenly arranged partitions can be selected, so that the receiving spaces of different heights can collect solid feces of different particle sizes separately, and samples of different particle sizes can be inserted into different receiving spaces respectively.

[0052] Embodiment 2 This embodiment provides a self-test device, see Figure 1 and Fig. 20 , including a solution tube 2, a detection tube 3 and a base 4.

[0053] Both ends of the detection tube are provided with openings, and the diameter of the detection tube gradually increases from the top to the bottom, that is, the cross-sectional shape of the detection tube is trapezoidal, at least a portion of the solution tube is sleeved in the detection tube, and the base cooperates with the opening at the bottom of the detection tube.

[0054] In some embodiments, the diameter of the portion of the solution tube extending into the detection tube is smaller than the inner diameter of the opening at the top of the detection tube, so that the solution tube can extend into the detection tube from the top of the solution tube, and the base is installed at the bottom of the detection tube from the opening at the bottom of the detection tube.

[0055] In some embodiments, see Figure 5 A limiting protrusion 47 is provided at the bottom of the base, and a limiting step 34 is provided at the bottom of the detection tube. When the base is installed in the detection tube, the limiting protrusion 47 abuts against the limiting step 34, thereby limiting the base and further ensuring the sealing between the two to prevent the solution from leaking out from the connection between the two.

[0056] See also Figure 4 , Figure 5 and Fig.11 The base includes a bottom cover 41, and an enclosure 42 and a puncture portion 43 arranged on the bottom cover. The outer wall of the enclosure 42 is in contact with the inner wall of the detection tube, that is, the base is also a trapezoidal structure. The puncture portion 43 is located in an enclosure space 46 formed by the enclosure 42. The inner diameter of the top of the enclosure 42 decreases from top to bottom, so that a transition slope 44 is formed at the top of the enclosure 42; a slot 45 is provided on one side of the enclosure, and a detection space 31 for accommodating a test strip is provided on the detection tube. An opening 32 connected to the slot 45 is provided at the bottom of the detection space 31, so that the first end of the test strip can extend from the opening 32 and pass through the slot 45 into the enclosure space 46.

[0057] In some embodiments, the height of the enclosure is less than the height of the detection tube, and the top of the enclosure is located in the lower half of the detection tube.

[0058] Compared with the straight tube structure in the prior art and the "nested layers" installation method from top to bottom, the present application provides a comprehensive anti-dumping self-test device by setting a truncated cone-shaped detection tube, and the detection tube and the base adopt a "semi-wrapped" matching method from bottom to top.

[0059] Specifically, the base cooperates with the detection tube through the opening at the bottom of the detection tube, and adopts a "bottom-to-top" installation method, so that the installed base is located in the lower half of the detection tube. On the one hand, the center of gravity of the self-test device can be concentrated at the bottom of the device, and combined with the truncated cone-shaped detection tube, it can prevent tipping to a certain extent. On the other hand, the test strip located in the detection tube can be directly introduced into the enclosure space during the installation process, which is convenient and quick, and there is no need to install an additional test strip accommodating structure.

[0060] Furthermore, a transition slope is provided on the top of the enclosure. Even if it falls over, the solution is difficult to leak out of the detection tube because the enclosure is close to the inner wall of the detection tube. After the self-test device is straightened, the solution above the enclosure can flow back into the enclosure space through the transition slope, further avoiding leakage.

[0061] In some embodiments, see Figure 4 The enclosure includes a first baffle 421 and a second baffle 422 which are arranged in sequence from the outside to the inside. The height of the second baffle 422 is lower than that of the first baffle 421. The first end of the first baffle 421 is connected to the first end of the second baffle 422 through a third baffle 423, and the transition slope is formed on the first surface of the third baffle 423. The outer wall of the first baffle 421 is in contact with the inner wall of the detection tube 3. The first baffle 421, the second baffle 422, the third baffle 423 and the bottom cover are enclosed to form a cavity 424.

[0062] In some embodiments, see Fig.11 The side of the enclosure 42 close to the opening is recessed downward along its height direction to form the slot 45, and the parts of the enclosure 42 located on both sides of the slot are respectively recessed inward to form a card slot 425 connected to the enclosure space, and the card slot 45 is arranged along the height direction of the enclosure 42; When the first end of the test strip is extended from the opening, and the first end of the test strip is extended into the enclosed space along the groove, the two sides of the first end of the test strip are snapped into the slot and fixed; wherein, the first end of the test strip refers to the end of the test strip that contacts the liquid.

[0063] Fixing the first end of the test strip by the slot can prevent the test strip from tilting after being bent through the opening and slot structure, thereby ensuring that the end of the test strip is always located at the bottom of the enclosure space to achieve liquid absorption.

[0064] In some embodiments, see Figure 5 The solution tube includes an integrally formed bottom plate 21 and a tube body, the bottom plate is arranged at the bottom of the tube body, and an opening is arranged at the top of the solution tube.

[0065] In some embodiments, a puncture groove 211 matching with the tip of the puncture portion is provided on the bottom plate 21 , and the thickness of the puncture groove 211 is smaller than the thickness of the bottom plate 21 .

[0066] In some embodiments, the solution tube is made of plastic.

[0067] Compared with the prior art which uses a solution tube with upper and lower openings and then sets an aluminum film at the bottom of the solution tube to achieve blocking, the present application designs an integrated solution tube with a puncture groove, which can simplify the production process, reduce costs, and does not increase the difficulty of puncture. During the puncture process, the bottom of the solution tube is broken along the puncture groove, that is, the solution enters the enclosure space through the crack formed after the puncture groove is broken, which can prevent larger particles in the solution from entering the enclosure space and directly contacting the test strip, thereby causing inaccurate measurement results.

[0068] In some embodiments, the limiting member is detachably disposed on the outside of the solution tube. In some specific embodiments, the limiting member includes an elastic clamping ring with an opening at one end, and a pull ring located on the opposite side of the opening. When in use, the clamping ring is clamped on the solution tube to limit the height of the solution tube to prevent the bottom plate at the bottom of the solution tube from contacting with the puncture part and being punctured; when the pull ring is pulled to remove the clamping ring from the solution tube, the solution tube is pressed downward, so that the bottom plate can contact the puncture part and be punctured by it.

[0069] In some embodiments, see Figure 3 A display area is provided on the detection tube, and a test strip mounting groove 33 is provided in the display area along the height direction of the detection tube. The test strip mounting groove 33 is connected with the opening, and the test strip is fixed in the test strip mounting groove by a fixing member 7. A display hole 71 is provided on the fixing member, and a transparent protective plate 8 is also provided on the outside of the fixing member.

[0070] In some embodiments, see Fig.18 A guide portion 23 is provided on the outer wall of the solution tube, and the outer diameter of the guide portion 23 gradually increases from the first end to the second end thereof, and the first end of the guide portion 23 smoothly transitions with the solution tube. The first end is the end of the guide portion close to the bottom plate of the solution tube, and the second end is the end of the guide portion close to the opening of the solution tube. By providing the guide portion, it is easier to press the solution tube downward and avoid jamming.

[0071] In some embodiments, the second end of the guide portion extends along the height direction of the solution tube to form a plurality of anti-slip strips 24 .

[0072] In some embodiments, the top of the solution tube extends upward to form a storage tank 25, and the cross-sectional shape of the storage tank is an inverted trapezoid. By setting the inverted trapezoidal storage tank, on the one hand, it can play a guiding role when the sampler is inserted into the solution tube, and on the other hand, the structure can collect excess samples. Specifically, during the user operation, the user usually holds the test tube with one hand and holds the gripping part with the other hand to insert the sampler back into the test tube. In this process, the sample may drip from the sampler, and the storage tank can collect the dripping sample to prevent the sample from dripping onto the user's hand.

[0073] In some embodiments, the storage tank and the solution tube are integrally formed. In some specific embodiments, the storage tank is made of plastic.

[0074] In summary, this embodiment provides an anti-dumping self-testing device by providing a truncated cone-shaped detection tube, and the detection tube and the base adopt a "half-wrapped" matching method.

[0075] Embodiment 3 This embodiment is basically as shown in the attached Figure 1-Figure 20 As shown: This embodiment provides an integrated sampling and detection device, including a sampler 1 and a self-testing device, wherein the self-testing device includes a solution tube 2, a detection tube 3, and a base 4. The sampler 1 may refer to the structure of the sampler 1 in the first embodiment, and the self-testing device may adopt the structure of the self-testing device in the second embodiment.

[0076] In some embodiments, the sampling and detection integrated device comprises: a sampler 1, a solution tube 2, a detection tube 3 and a base 4; both ends of the detection tube 3 are provided with openings, and the diameter of the detection tube 3 gradually increases from the top to the bottom, at least a part of the solution tube 2 is sleeved in the detection tube 3, at least a part of the sampler 1 is sleeved in the solution tube 2, and the base 4 cooperates with the opening at the bottom of the detection tube 3; The base 4 includes a bottom cover 41, and an enclosure and a puncture portion 43 arranged on the bottom cover 41, the outer wall of the enclosure is in contact with the inner wall of the detection tube 3, the puncture portion 43 is located in an enclosure space 46 formed by the enclosure, and the inner diameter of the top of the enclosure decreases from top to bottom, so that a transition slope 44 is formed on the top of the enclosure; a groove 45 is provided on one side of the enclosure, and a detection space 31 for accommodating a test strip is provided on the detection tube 3, and an opening 32 connected to the groove 45 is provided at the bottom of the detection space 31, so that the first end of the test strip can extend from the opening 32 and pass through the groove 45 into the enclosure space 46.

[0077] In some embodiments, the enclosure includes a first baffle 421 and a second baffle 422 which are arranged in sequence from the outside to the inside, the height of the second baffle 422 is lower than the height of the first baffle 421, the first end of the first baffle 421 is connected to the first end of the second baffle 422 through a third baffle 423, and the transition slope 44 is formed on the first surface of the third baffle 423; the outer wall of the first baffle 421 is in contact with the inner wall of the detection tube 3; the first baffle 421, the second baffle 422, the third baffle 423 and the bottom cover 41 are enclosed to form a cavity 424.

[0078] In some embodiments, the side of the enclosure close to the opening 32 is recessed downward along its height direction to form the groove 45, and the parts of the enclosure located on both sides of the groove 45 are respectively recessed inward to form a slot 425 connected to the enclosure space 46, and the slot 425 is arranged along the height direction of the enclosure; when the first end of the test strip is extended from the opening 32 and the first end of the test strip is extended into the enclosure space 46 along the slot 425, the two sides of the first end of the test strip are fixed in the slot 425.

[0079] In some embodiments, the solution tube 2 includes an integrally formed bottom plate 21 and a tube body 22 , wherein the bottom plate 21 is disposed at the bottom of the tube body 22 , and an opening cooperating with the sampler 1 is disposed at the top of the solution tube 2 .

[0080] In some embodiments, the solution tube is provided with a mounting portion having a first inner diameter and a solution cavity having a second inner diameter from top to bottom. When the sampler is inserted into the solution cavity, the coupling portion of the sampler is located in the mounting portion, and the collecting portion is located inside the solution cavity.

[0081] In some embodiments, a puncture groove 211 is provided on the bottom plate 21 to cooperate with the tip of the puncture portion 43 , and the thickness of the puncture groove 211 is smaller than the thickness of the bottom plate 21 .

[0082] When using this device, refer to Figure 6-Figure 10 , Figure 6 The schematic diagram of the device in the initial state is shown. When using it, first hold the gripping part, pull the sampler out of the solution tube, and then extend the collecting part of the sampler into the sample to collect the sample (see Figure 7 ), and then reinsert the sampler into the solution tube so that the sample in the collection part contacts the solution in the solution tube (see Figure 8 ); then remove the stopper on the solution tube (see Fig. 9 ), press the gripping part downward, so that the gripping part drives the solution tube downward, and then the bottom plate of the solution tube contacts the tip of the puncture part and is punctured (see Fig.10 ), the liquid containing the sample dissolved in the solution tube passes through the gap formed by the puncture groove part of the bottom plate, and flows into the enclosure space to contact the first end of the test strip, finally running the plate, and displaying the test result in the display area outside the solution tube. In this process, the liquid level of the solution in the enclosure is always below the slot, that is, in the normal upright state, the solution will not enter the test tube, thereby avoiding solution leakage.

[0083] The integrated stool sampling and testing device with the above structure provides a self-testing device that prevents tipping by providing a truncated cone-shaped testing tube, wherein the testing tube and the base are matched in a "semi-wrapped" manner, and a "semi-hollow" grip is provided.

[0084] Specifically, the base cooperates with the detection tube through the opening at the bottom of the detection tube, and adopts a "bottom-to-top" installation method, so that the installed base is located in the lower half of the detection tube. On the one hand, the center of gravity of the self-test device can be concentrated at the bottom of the device, and combined with the truncated cone-shaped detection tube, it can prevent tipping to a certain extent. On the other hand, the test strip located in the detection tube can be directly introduced into the enclosure space during the installation process, which is convenient and quick, and there is no need to install an additional test strip accommodating structure.

[0085] Furthermore, a transition slope is provided on the top of the enclosure. Even if it falls over, the solution is difficult to leak out of the detection tube because the enclosure is close to the inner wall of the detection tube. After the self-test device is straightened, the solution above the enclosure can flow back into the enclosure space through the transition slope, further avoiding leakage.

[0086] Furthermore, by providing a spherical grip, it is convenient for the user to apply force when pressing the grip and pulling the sampler out of the self-test device; in addition, the grip adopts a hollow structure (anti-slip groove), which can save production costs on the one hand, and reduce the weight of the grip on the other hand, thereby preventing the sampler from becoming "top-heavy" and tipping over when cooperating with the self-test device.

[0087] Embodiment 4 Different from the third embodiment, see Fig.21 The sampler 1 in this embodiment is an independent sampling structure, such as a swab; see Fig. 22 The self-test device also includes an independent upper cover 10, which is detachably arranged in the opening at the top of the solution tube. The upper cover 10 is used to cooperate with the solution tube to seal the solution inside the solution tube in the solution tube.

[0088] In some embodiments, the upper cover 10 includes a gripping portion 11 and a coupling portion 12 which are sequentially connected from top to bottom.

[0089] In some embodiments, see Fig.14 The gripping portion is spherical, and the inner diameter of the gripping portion gradually increases and then decreases from the first end to the second end, and a plurality of anti-slip grooves 111 are circumferentially arranged on the gripping portion.

[0090] In some specific embodiments, the anti-slip grooves are multiple grooves formed by the surface of the spherical gripping portion being recessed inwardly along the width direction.

[0091] In some embodiments, the plurality of grooves are evenly distributed on the spherical gripping portion.

[0092] In some embodiments, a sealing ring 9 is provided on the coupling portion 12 .

[0093] By providing a spherical grip, it is convenient for the user to apply force when pressing the grip and pulling the sampler out of the self-test device. In addition, the grip adopts a hollow structure (anti-slip groove), which can save production costs on the one hand, and reduce the weight of the grip on the other hand, thereby preventing the sampler from becoming "top-heavy" and tipping over when cooperating with the self-test device.

[0094] The sampling and detection integrated device with the above structure is used as follows: See also Fig.24 , the figure shows a schematic diagram of the device in its initial state. When in use, firstly, a separate sampling structure (preferably a swab) is used to take a sample, then the grip portion is held, the upper cover is removed from the solution tube, and then the swab is immediately inserted into the solution tube for dissolution (see Fig.25 ), then take the swab out of the solution tube, and put the upper cover back into the solution tube, then remove the limiter on the solution tube, press the gripping part downward, so that the gripping part drives the solution tube to move downward, and then the bottom plate at the bottom of the solution tube contacts and is punctured by the tip part of the puncture part, and the liquid containing the sample dissolved in the solution tube flows into the enclosure space and contacts the first end of the test strip, finally realizing the running board, and displaying the test result in the display area outside the solution tube.

[0095] Embodiment 5 The difference from the first to fourth embodiments is that, see Fig.23 , a scraping structure 20 is provided inside the solution tube. The scraping structure 20 includes a collection area 202 and a scraping area 203 arranged sequentially from top to bottom, and the scraping area 203 is provided with at least two scraping protrusions 204, and a scraping groove 205 is formed between two adjacent scraping protrusions 204. In some embodiments, the inner diameters of the exchange area and the collection area 202 gradually decrease from top to bottom, and the inner diameter of the scraping area 203 is the same along the height direction of the solution tube, so that the scraping structure 20 is funnel-shaped.

[0096] In some embodiments, the scraping structure 20 may be fixedly disposed inside the solution tube. In other embodiments, the scraping structure 20 may also be movably disposed inside the solution tube, similar to the structure of a piston.

[0097] It should be noted that the scraping structure is tightly connected to the solution tube. Even if the scraping structure is movably arranged in the solution tube, the sampling structure (sampler or swab) will not drive the scraping structure to move when passing through the scraping structure.

[0098] For samples with larger volumes, such as feces (especially solid feces), the scraping structure 20 can be set in the upper half of the solution tube, that is, above the liquid surface in the solution tube. When the sampler (for the specific structure, see Example 1) is inserted into the solution tube, the collecting part of the sampler passes through the scraping structure 20, and samples with larger particles (such as solid feces) fall off the sampler under the action of the scraping structure 20 and are collected in the collecting area 202, so as to prevent the sample from dissolving too much into the solution in the solution tube, and to prevent large particle samples from entering the enclosed space and directly contacting the test strip, resulting in inaccurate measurement results.

[0099] That is to say, the present application double-restricts large particle samples (first, restricts them to the collection area, and even if large particle samples accidentally fall under the scraping structure, they are also restricted above the bottom plate with a smaller gap after tearing), thereby effectively preventing them from entering the "open" enclosure space and directly contacting the test strip built in it, resulting in inaccurate measurement results. Among them, "open" means that there is no obstruction above the enclosure space and it is connected to the internal space of the detection tube.

[0100] In some embodiments, at least one exchange hole 206 is disposed on the top of the collection area 202 to form a solution exchange area 201 on the top of the collection area.

[0101] In some embodiments, a plurality of exchange holes 206 are arranged along the circumference of the solution exchange area 201, and the plurality of exchange holes 206 are all located at the top of the solution exchange area 201, that is, located at the side where the solution exchange area 201 is connected to the solution tube.

[0102] For samples with smaller quantity and / or volume, such as viruses, the scraping structure 20 can be set in the lower half of the solution tube so that it is immersed in the solution in the solution tube. When the swab is inserted into the solution tube, the sample is fully dissolved in the solution by scraping the swab on the scraping protrusion 204. In the scraping process, the solutions on the upper and lower sides of the scraping structure 20 can also be exchanged through the exchange hole 206 under the stirring action of the swab, as well as exchanged through the gap between the sampler and the scraping structure 20, so as to flush the sample on the scraping structure, so that the sample in the solution is more evenly distributed. Even if the sample or swab completely blocks the scraping area 203, the exchange hole 206 can still meet the solution exchange needs, thereby preventing the generation of negative pressure that makes it difficult to remove the sampler.

[0103] In some embodiments, see Fig. 27 The scraping structure further includes a support portion 207, the inner diameter of which increases from top to bottom, the top of which is connected to the bottom of the scraping area, and the bottom of which is against the inner wall of the tube body. That is, both ends of the scraping structure are configured to be trumpet-shaped.

[0104] In some embodiments, at least one through hole 208 is disposed on the support portion 207 , and the through hole 208 is connected to the exchange hole 206 .

[0105] In some embodiments, the outer diameter of the scraping structure is the same from top to bottom, and the outer wall of the scraping structure is tightly connected to the inner wall of the tube body. At least one exchange channel is provided in the scraping structure, and the exchange hole and the through hole are connected through the exchange channel.

[0106] The scraping structure with the above structure can guide the swab and scrape the sample on the swab. First, the solution below the scraping structure and the solution above the scraping structure can be exchanged through the exchange holes, exchange channels and through holes that are connected in sequence, so that the sample distribution in the solution is more uniform. In addition, even if the swab is offset in the solution tube, it can move up and down unimpeded under the guidance of the trumpet-shaped support part and the collection area, avoiding the situation where the swab is stuck in the scraping structure and cannot be moved or removed. In addition, the outer wall of the scraping structure is tightly connected to the inner wall of the tube body. On the one hand, it can enhance the connection strength between the movable scraping structure and the tube body. On the other hand, the larger scraping structure can fill the internal space of the solution tube, thereby reducing the filling amount of the solution, saving production costs, and making the sample concentration in the solution higher.

[0107] In summary, for samples of different volumes / quantities, the present application provides a solution that enables the samples to be "quantitatively" dissolved into the solution. Specifically, by adjusting the height of the scraping structure, excess samples are excluded from the solution, and smaller sample volumes can be dissolved in the solution as much as possible, and a higher sample concentration is ensured. That is, whether it is a larger sample (such as feces) or a smaller sample in quantity and / or volume (such as a virus), the present device can stably collect and detect it, thereby ensuring the reliability of the test results.

[0108] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0109] The embodiments of the present invention are described above in conjunction with the accompanying drawings, but the present invention is not limited to the above-mentioned specific implementation modes, which are merely illustrative rather than restrictive. Under the guidance of the present invention, ordinary technicians in this field can also make many forms without departing from the scope of protection of the present invention and the claims, all of which are within the protection of the present invention.

Claims

1. A sampling and detection integrated device, characterized in that: include: A sampler (1), a solution tube (2), a detection tube (3) and a base (4); both ends of the detection tube (3) are provided with openings, and the diameter of the detection tube (3) gradually increases from the top to the bottom, at least a portion of the solution tube (2) is sleeved in the detection tube (3), at least a portion of the sampler (1) is sleeved in the solution tube (2), and the base (4) cooperates with the opening at the bottom of the detection tube (3); The base (4) comprises a bottom cover (41), and a baffle (42) and a puncture portion (43) arranged on the bottom cover (41); the outer wall of the baffle is in contact with the inner wall of the detection tube (3); the puncture portion (43) is located in a baffle space (46) formed by the baffle (42); the inner diameter of the top of the baffle (42) decreases from top to bottom, so that a transition slope (44) is formed at the top of the baffle (42); a slot (45) is arranged on one side of the baffle; a detection space (31) for accommodating a test strip (6) is arranged on the detection tube (3); an opening (32) connected to the slot (45) is arranged at the bottom of the detection space (31), so that the first end of the test strip (6) can extend from the opening (32) and pass through the slot (45) into the baffle space (46).

2. A sampling and detection integrated device according to claim 1, characterized in that: The enclosure comprises a first baffle (421) and a second baffle (422) which are arranged in sequence from the outside to the inside, the height of the second baffle (422) is lower than the height of the first baffle (421), the first end of the first baffle (421) is connected to the first end of the second baffle (422) via a third baffle (423), and the transition slope (44) is formed on the first surface of the third baffle (423); the outer wall of the first baffle (421) is in contact with the inner wall of the detection tube (3); the first baffle (421), the second baffle (422), the third baffle (423) and the bottom cover (41) are enclosed to form a cavity (424).

3. The integrated sampling and detection device according to claim 2, characterized in that: The side of the enclosure close to the opening (32) is recessed downward along its height direction to form the slot (45), and the parts of the enclosure located on both sides of the slot (45) are respectively recessed inward to form slots (425) communicating with the enclosure space (46), and the slots (425) are arranged along the height direction of the enclosure; When the first end of the test strip is extended from the opening (32), and the first end of the test strip is extended into the enclosed space (46) along the clamping groove (425), two sides of the first end of the test strip are clamped into the clamping groove (425) and fixed.

4. The integrated sampling and detection device according to claim 1, characterized in that: The solution tube (2) comprises an integrally formed bottom plate (21) and a tube body (22); the bottom plate (21) is arranged at the bottom of the tube body (22); an opening cooperating with the sampler (1) is arranged at the top of the solution tube (2); a puncture groove (211) cooperating with the tip of the puncture portion (43) is arranged on the bottom plate (21); the thickness of the puncture groove (211) is smaller than the thickness of the bottom plate (21).

5. The integrated sampling and detection device according to claim 1, characterized in that: A scraping structure (20) is arranged inside the solution tube (2), and the scraping structure (20) comprises a solution exchange area (201), a collection area (202), and a scraping area (203) arranged in sequence from top to bottom, the solution exchange area (201) is provided with at least one exchange hole (206), the scraping area (203) is provided with at least two scraping protrusions (204), and a scraping groove (205) is formed between two adjacent scraping protrusions (204); The inner diameters of the exchange area and the collection area (202) gradually decrease from top to bottom, and the inner diameter of the scraping area (203) is the same along the height direction of the solution tube, so that the scraping structure (20) is funnel-shaped.

6. A sampler, characterized in that: include: A gripping portion (11), a coupling portion (12), a sampling rod (13) and a collecting portion (14) are connected in sequence from top to bottom, the collecting portion (14) is hollowed out to form an installation space, at least one partition (144) is arranged in the installation space along the width direction of the collecting portion (14), and the at least one partition (144) divides the installation space into at least two accommodating chambers (145); a pointed structure (141) is arranged at the first end of the collecting portion (14), the pointed structure (141) comprises a first surface, a second surface, a third surface and a fourth surface connected in sequence, the first surface, the second surface, the third surface and the fourth surface are arranged along the circumference of the pointed structure (141); wherein the first surface and the third surface are respectively recessed inwards to form a guide area (142) having a first inclination.

7. The sampler according to claim 6, characterized in that: The partition (144) is provided with a plurality of anti-slip protrusions (401) and / or a plurality of recessed portions, and adjacent anti-slip protrusions (401) cooperate with the partition (144) to form a limiting structure, thereby dividing the accommodating cavity (145) into a plurality of accommodating areas (402).

8. The sampler according to claim 6, characterized in that: A plurality of the partition plates (144) are provided, and the plurality of the partition plates (144) are evenly arranged in the installation space, so that the heights of the plurality of the accommodating cavities (145) are the same.

9. The sampler according to claim 6, characterized in that: A plurality of partition plates (144) are provided, and the plurality of partition plates (144) are non-uniformly arranged in the installation space to form a plurality of accommodating cavities (145) of different heights.

10. The sampler according to claim 6, characterized in that The second end of the installation space extends toward the second end of the collecting portion (14), forming a transition zone (143) with a second inclination.

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