Soothing acne-removing spray and application thereof

Abstract

The invention belongs to the technical field of cosmetic preparation, and particularly relates to a relieving and acne removing spray and application, the spray comprises an agent A and an agent B, wherein the agent A is prepared from the following raw materials in percentage by mass: 2 to 3 percent of humectants, 1 to 1.5 percent of penetrating agents, 0.1 to 0.2 percent of salicylic acid microcapsules, 0.1 to 0.2 percent of preservatives, 0.6 to 0.8 percent of conditioning agents, 0.05 to 0.15 percent of buffering agents, 1.5 to 1.8 percent of plant extracts and the balance of deionized water; the agent B is prepared from the following raw materials in percentage by mass: 10 to 12 percent of chloramphenicol and the balance of solvent. The soothing acne-removing spray prepared by the invention has the advantages of quick effect and no irritation.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetic preparation, and particularly relates to a soothing acne spray and its application. Background Art

[0002] With the rapid development of society, people's diet and work and rest are irregular, mood swings are large, and stress multiplies, resulting in disorders in sebum metabolism, increased sebum secreted by sebaceous glands, accumulation of oil in hair follicles, excessive proliferation of keratinocytes at the hair follicle orifice, resulting in blockage of the hair follicle orifice, breeding of bacteria and inflammation, or hormonal level fluctuations during special periods such as adolescence and menstrual cycles, which may also affect sebum secretion. These are all the reasons for acne. To remove acne, first, it is necessary to remove the sebum blocking the hair follicles, restore the hair follicles to be unobstructed, and then perform antibacterial and anti-inflammatory treatments to make the skin reach a stable state, so as to achieve the purpose of removing acne.

[0003] Patent CN111388405B discloses an oil-control and acne-removing composition, which includes the following components: filtrate of Lactobacillus / Pear Juice Fermentation Product, White Willow Bark Extract, Phellodendron Bark Extract, Houttuynia Cordata Extract, Japanese Beautyberry Fruit Extract, Matrine, Centella Asiatica Extract, Scutellaria Baicalensis Root Extract, Royal Jelly Oil-Control Composition, Olea Europaea Leaf Extract, Paeonia Suffruticosa Root Extract, Saurauia Tristyla Extract, Bergamot Leaf Extract. Through the reasonable preparation of various nutritional components, the invention has good oil-control and acne-inhibiting effects, can condition and stabilize the skin, and effectively reduce the recurrence of acne, but the treatment time using only the plant extract composition is relatively long.

[0004] Patent CN114848565B discloses an acne-removing composition, an acne-removing gel and its preparation method. The acne-removing composition includes the following components in parts by weight: Portulaca oleracea Extract, Platycladus orientalis Extract, Ginger Root Extract, Niacinamide, Betaine Salicylate, Bisabolol. The composition has the advantages of dredging pores, antibacterial and bactericidal, fast healing speed, and no scar or melanin deposition left after healing, but the Betaine Salicylate used has relatively large irritation and causes pain when used on ruptured acne.

[0005] Therefore, there is an urgent need in the market for an acne-removing product with fast efficacy and comfortable use. Summary of the Invention

[0006] In order to overcome the deficiencies of the above-mentioned prior art, the present invention provides a soothing acne spray with fast efficacy, comfortable use and no irritation.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is:

[0008] In the first aspect of the present invention, a soothing acne spray is provided, which comprises Agent A and Agent B; based on 100% by mass percentage, Agent A comprises the following raw materials: 2-3% of a humectant, 1-1.5% of a penetrant, 0.1-0.2% of salicylic acid microcapsules, 0.1-0.2% of a preservative, 0.6-0.8% of a regulator, 0.05-0.15% of a buffer, 1.5-1.8% of a plant extract, and the balance is deionized water; based on 100% by mass percentage, Agent B comprises the following raw materials: 10-12% of chloramphenicol, and the balance is a solvent.

[0009] Preferably, the solvent is propylene glycol and ethanol, and the mass ratio of the two is 1:(1-1.5).

[0010] In some embodiments, the preparation method of the salicylic acid microcapsules comprises the following steps:

[0011] (1) Add phospholipids, menthyl lactate and olive oil to deionized water, adjust the pH to 9-11, react at 40-50 °C for 1-3 h, and perform rotary evaporation to obtain the shell layer raw material;

[0012] (2) Add xanthan gum and sodium cocoyl glycinate to propylene glycol to obtain an alcohol phase;

[0013] (3) Add salicylic acid and the shell layer raw material obtained in step (1) to the alcohol phase obtained in step (2), then add deionized water, pre-homogenize at 70-80 °C for 10-15 min, and then perform high-pressure homogenization at 80-100 MPa for 2-3 cycles to obtain salicylic acid microcapsules.

[0014] Preferably, the mass ratio of xanthan gum, sodium cocoyl glycinate to propylene glycol in step (2) is 1:(0.1-0.2):(60-62).

[0015] Preferably, the mass of the alcohol phase in step (3) is 2.5-3.5 times the total mass of salicylic acid and the shell layer raw material; the mass of deionized water is 0.6-0.7 times the total mass of salicylic acid and the shell layer raw material.

[0016] When using salicylic acid on sensitive skin, it is necessary to build tolerance. And when there are wounds on the surface of acne, there will be pain, and the user experience is not good. In the present invention, lactic acid menthyl ester and olive oil are used to modify phospholipids to prepare the shell material for preparing salicylic acid microcapsules. It has good affinity with the skin, can make salicylic acid release slowly, and prevent salicylic acid from quickly contacting the wound, so the user feels better. At the same time, on the one hand, olive oil can increase the water resistance of the shell material so that salicylic acid will not easily precipitate in water, improving the encapsulation rate of salicylic acid. On the other hand, it can provide nutrition and moisture for the skin, and has an anti-inflammatory effect, which can reduce skin inflammation, promote the metabolism of skin cells, and accelerate the skin repair and renewal process. Lactic acid menthyl ester can be quickly absorbed by the skin to achieve a certain cooling effect, and can slow down the pain and itching problems caused by the use of drugs such as chloramphenicol and salicylic acid.

[0017] In some embodiments, the mass ratio of the phospholipid to lactic acid menthyl ester in step (1) is 1:(0.8 - 1).

[0018] In some embodiments, the mass ratio of the phospholipid to olive oil in step (1) is 1:(0.6 - 0.9).

[0019] By limiting the mass ratio of the phospholipid to olive oil, the present invention enables the shell material to have good water resistance while not affecting its affinity with the skin and not disturbing the skin's water-oil balance.

[0020] In some embodiments, the mass ratio of the salicylic acid to the shell material in step (3) is 1:(18 - 22).

[0021] By the mass ratio of the salicylic acid to the shell material, the present invention enables salicylic acid to be fully encapsulated, have strong affinity with the skin, and not affect the release of salicylic acid.

[0022] In some embodiments, the plant extract is Balaba extract, hawthorn leaf extract and tangerine peel extract, and the mass ratio of the three is (0.6 - 0.8):(0.4 - 0.6):1.

[0023] In some embodiments, the preparation method of the tangerine peel extract includes the following steps: crushing the tangerine peel to obtain tangerine peel powder, grinding the tangerine peel powder and modified molecular sieve for 2 - 3 minutes, filling a solid-phase extraction column, then eluting with an eluent, collecting the eluate, centrifuging, taking the supernatant, and drying to obtain the tangerine peel extract.

[0024] Preferably, the mass ratio of the tangerine peel powder to the modified molecular sieve is 1:(0.9 - 1.2).

[0025] In some embodiments, the preparation method of the modified molecular sieve includes the following steps:

[0026] 1) Add the molecular sieve and KH570 to ethanol, react at 50 - 60 °C for 5 - 6 h, then add acrylic acid and azobisisobutyronitrile, and continue to react for 1 - 2 h to obtain acrylic acid - modified molecular sieve;

[0027] 2) Add the acrylic acid - modified molecular sieve, choline chloride and phosphoric acid obtained in step 1) to DMF, react at 70 - 80 °C for 4 - 5 h, filter, wash and dry to obtain the modified molecular sieve.

[0028] In the present invention, by using the modified molecular sieve to extract tangerine peel, the prepared anti - acne spray has a good anti - acne effect. The possible reason is that the quaternary ammonium salt group is added to the modified molecular sieve, which is a hydrogen - bond acceptor, and a large number of hydroxyl groups are contained in the active ingredients of the tangerine peel extract, which are hydrogen - bond donors, and have a strong interaction with the modified molecular sieve. Under the action of the porous structure of the molecular sieve, the extraction rate of tangerine peel is improved.

[0029] In some embodiments, the mass ratio of the molecular sieve to acrylic acid in step 1) is 1:(0.5 - 0.7).

[0030] In some embodiments, the mass ratio of the acrylic acid - modified molecular sieve to choline chloride in step 2) is 1:(0.7 - 0.9).

[0031] By limiting the mass ratio of the molecular sieve to acrylic acid and simultaneously limiting the mass ratio of the acrylic acid - modified molecular sieve to choline chloride, on the one hand, enough carboxyl groups are grafted onto the molecular sieve to react with choline chloride, and at the same time, it is avoided that too long alkyl chains affect the hydrogen - bond interaction between the modified molecular sieve and the tangerine peel extract.

[0032] In some embodiments, the preparation method of the agent A comprises the following steps: Add a humectant, a penetrant, salicylic acid microcapsules, a preservative, a regulator, a buffer, and a plant extract to deionized water and stir for 40 - 50 min to obtain it.

[0033] In some embodiments, the preparation method of the agent B comprises the following steps: Add chloramphenicol to a solvent and stir for 20 - 30 min to obtain it.

[0034] In the second aspect of the present invention, an application of a soothing anti - acne spray is provided, and the agent A and the agent B are sprayed on the affected area in sequence.

[0035] In the present invention, the agent A is first sprayed on the affected area. The salicylic acid shell has good affinity with the skin. When the agent B is sprayed on the affected area, ethanol gradually dissolves the shell layer, salicylic acid precipitates, and a good anti - acne effect can be achieved under the synergistic effect with chloramphenicol. At the same time, the salicylic acid shell layer can relieve the discomfort brought by drug treatment.

[0036] Compared with the prior art, the present invention has the following beneficial effects:

[0037] 1. The present invention prepares a two-component acne spray by using salicylic acid microcapsules, plant extracts, and chloramphenicol. The usage method is simple, with good therapeutic effects and no irritation.

[0038] 2. The present invention modifies phospholipids by using menthyl lactate and olive oil to prepare the shell material, and prepares salicylic acid microcapsules. It has good affinity with the skin, can slowly release salicylic acid, prevent salicylic acid from quickly contacting the wound, making people feel better when using it. At the same time, on the one hand, olive oil can increase the water resistance of the shell material so that salicylic acid will not easily precipitate in water, improve the encapsulation rate of salicylic acid, and on the other hand, it can provide nutrition and moisture for the skin, and has an anti-inflammatory effect, which can reduce skin inflammation symptoms, promote the metabolism of skin cells, and accelerate the skin repair and renewal process. Menthol lactate can be quickly absorbed by the skin to achieve a certain cooling effect, and can alleviate the pain and itching problems caused by the use of drugs such as chloramphenicol and salicylic acid.

[0039] 3. The present invention extracts tangerine peel by modifying molecular sieves. Quaternary ammonium salt groups are added to the modified molecular sieves, which are hydrogen bond acceptors. A large number of hydroxyl groups are contained in the active ingredients of the tangerine peel extract, which are hydrogen bond donors, and have strong interactions with the modified molecular sieves. Under the action of the porous structure of the molecular sieve, the extraction rate of tangerine peel is improved, and the acne-removing effect of the acne spray is enhanced.

[0040] 4. The present invention first sprays agent A on the affected area. The salicylic acid shell has good affinity with the skin. When agent B is sprayed on the affected area, ethanol gradually dissolves the shell, and salicylic acid precipitates. With the synergistic effect of chloramphenicol, a good acne-removing effect can be achieved. At the same time, the salicylic acid shell can relieve the discomfort caused by drug treatment. Specific Embodiments

[0041] The following will illustrate the present invention in combination with specific implementation schemes. It should be noted that the following examples and comparative examples are only used to illustrate the present invention, rather than to limit the present invention. Other combinations and various improvements within the concept of the present invention can be made without departing from the main idea or scope of the present invention.

[0042] For the convenience of those skilled in the art to implement the present invention, some raw materials and manufacturers of the examples and comparative examples are described as follows:

[0043] The compounds and related reagents used in the following examples and comparative examples can all be purchased from the market. Among them, phospholipids are hydrogenated soy lecithin, purchased from Xi'an Rongzhen Biotechnology Co., Ltd.; olive oil is purchased from Zhuhai Shixin Biotechnology Co., Ltd.; molecular sieves are mesoporous SBA-15 molecular sieves, purchased from Raodong (Liaoning) New Materials Co., Ltd.; tangerine peel is purchased from Bozhou Renyi Chinese Herbal Medicine Sales Co., Ltd.

[0044] Preparation Example 1

[0045] The preparation method of salicylic acid microcapsule-1 comprises the following steps:

[0046] (1) Add 10 g of phospholipid, 9 g of menthyl lactate and 7 g of olive oil into deionized water, adjust the pH to 10, react at 45 °C for 2 h, and perform rotary evaporation to obtain the shell raw material;

[0047] (2) Add 10 g of xanthan gum and 1.5 g of sodium cocoyl glycinate into 61 g of propylene glycol to obtain the alcohol phase;

[0048] (3) Add 1 g of salicylic acid and 20 g of the shell raw material obtained in step (1) into the alcohol phase obtained in step (2). The mass of the alcohol phase is 3 times the total mass of salicylic acid and the shell raw material. Then add deionized water. The mass of deionized water is 6.5 times the total mass of salicylic acid and the shell raw material. Perform pre-homogenization at 75 °C for 13 min, and then perform high-pressure homogenization at 90 MPa for 3 cycles to obtain salicylic acid microcapsule-1.

[0049] Preparation Example 2

[0050] The preparation method of salicylic acid microcapsule-2 is the same as that of Preparation Example 1 in specific implementation manner, except that the addition amount of olive oil in step (1) is 11 g.

[0051] Preparation Example 3

[0052] The preparation method of salicylic acid microcapsule-3 is the same as that of Preparation Example 1 in specific implementation manner, except that the addition amount of the shell raw material in step (2) is 16 g.

[0053] Preparation Example 4

[0054] The preparation method of modified molecular sieve-1 comprises the following steps:

[0055] 1) Add 10 g of molecular sieve and 4 g of KH570 into 100 ml of absolute ethanol, react at 55 °C for 5.5 h, then add 6 g of acrylic acid and 0.05 g of azobisisobutyronitrile, and continue to react for 1.5 h to obtain acrylic acid-modified molecular sieve;

[0056] 2) Add 10 g of the acrylic acid-modified molecular sieve obtained in step 1), 8 g of choline chloride and 5 ml of 75 wt% phosphoric acid into 50 ml of DMF, react at 75 °C for 4.5 h, filter, wash and dry to obtain modified molecular sieve-1.

[0057] Preparation Example 5

[0058] The preparation method of modified molecular sieve-2 is the same as that of Preparation Example 4 in specific implementation manner, except that the addition amount of acrylic acid is 9 g.

[0059] Preparation Example 6

[0060] Preparation method of modified molecular sieve-3. The specific implementation is the same as that of Preparation Example 4, except that the addition amount of choline chloride is 11 g.

[0061] Preparation Example 7

[0062] Preparation method of tangerine peel extract-1, comprising the following steps: pulverize 20 g of tangerine peel to obtain tangerine peel powder, grind 10 g of tangerine peel powder and 10 g of modified molecular sieve-1 for 3 min, fill a solid-phase extraction column, then elute with 250 ml of methanol, collect the eluate, centrifuge, take the supernatant, and dry to obtain tangerine peel extract-1.

[0063] Preparation Example 8

[0064] Preparation method of tangerine peel extract-2. The specific implementation is the same as that of Preparation Example 7, except that modified molecular sieve-1 is equally replaced by modified molecular sieve-2.

[0065] Preparation Example 9

[0066] Preparation method of tangerine peel extract-3. The specific implementation is the same as that of Preparation Example 7, except that modified molecular sieve-1 is equally replaced by modified molecular sieve-3.

[0067] Preparation Example 10

[0068] Preparation method of tangerine peel extract-4. The specific implementation is the same as that of Preparation Example 7, except that modified molecular sieve-1 is equally replaced by molecular sieve.

[0069] Example 1

[0070] A soothing acne spray, comprising Agent A and Agent B; Agent A is calculated as 100% by mass percentage and comprises the following raw materials: propylene glycol 2.5%, disodium laureth sulfosuccinate 1.3%, salicylic acid microcapsule-1 0.15%, sodium benzoate 0.15%, sodium chloride 0.7%, potassium dihydrogen phosphate 0.1%, plant extract 1.7%, deionized water 93.4%, and the plant extract is barbara extract, hawthorn leaf extract and tangerine peel extract-1, and the mass ratio of the three is 0.7:0.5:1; Agent B is calculated as 100% by mass percentage and comprises the following raw materials: chloramphenicol 11%, solvent 89%, and the solvent is propylene glycol and 75% vol ethanol solution, and the mass ratio of the two is 1:1.3.

[0071] Example 2

[0072] A soothing acne-relieving spray, comprising Agent A and Agent B; Agent A, calculated on a mass percentage of 100%, comprises the following raw materials: propylene glycol 2%, disodium laureth sulfosuccinate 1%, salicylic acid microcapsule-1 0.1%, sodium benzoate 0.1%, sodium chloride 0.6%, potassium dihydrogen phosphate 0.05%, plant extract 1.5%, deionized water 94.65%, and the plant extract is barab extract, hawthorn leaf extract and tangerine peel extract-1, and the mass ratio of the three is 0.6:0.4:1; Agent B, calculated on a mass percentage of 100%, comprises the following raw materials: chloramphenicol 10%, solvent 90%, and the solvent is propylene glycol and 75% vol ethanol solution, and the mass ratio of the two is 1:1.

[0073] Example 3

[0074] A soothing acne-relieving spray, comprising Agent A and Agent B; Agent A, calculated on a mass percentage of 100%, comprises the following raw materials: propylene glycol 3%, disodium laureth sulfosuccinate 1.5%, salicylic acid microcapsule-1 0.2%, sodium benzoate 0.2%, sodium chloride 0.8%, potassium dihydrogen phosphate 0.15%, plant extract 1.8%, deionized water 92.35%, and the plant extract is barab extract, hawthorn leaf extract and tangerine peel extract-1, and the mass ratio of the three is 0.8:0.6:1; Agent B, calculated on a mass percentage of 100%, comprises the following raw materials: chloramphenicol 12%, solvent 88%, and the solvent is propylene glycol and 75% vol ethanol solution, and the mass ratio of the two is 1:1.5.

[0075] Example 4

[0076] A soothing acne-relieving spray, the specific implementation manner is the same as that of Example 1, the difference is that salicylic acid microcapsule-1 is replaced with salicylic acid microcapsule-2 in equal amount.

[0077] Example 5

[0078] A soothing acne-relieving spray, the specific implementation manner is the same as that of Example 1, the difference is that salicylic acid microcapsule-1 is replaced with salicylic acid microcapsule-3 in equal amount.

[0079] Example 6

[0080] A soothing acne-relieving spray, the specific implementation manner is the same as that of Example 1, the difference is that tangerine peel extract-1 is replaced with tangerine peel extract-2 in equal amount.

[0081] Example 7

[0082] A soothing acne-relieving spray, the specific implementation manner is the same as that of Example 1, the difference is that tangerine peel extract-1 is replaced with tangerine peel extract-3 in equal amount.

[0083] Example 8

[0084] A soothing acne-relieving spray, the specific implementation method is the same as that of Example 1, the difference is that tangerine peel extract-1 is replaced with tangerine peel extract-4 in equal amount.

[0085] Comparative Example 1

[0086] A soothing acne-relieving spray, the specific implementation method is the same as that of Example 1, the difference is that salicylic acid microcapsule-1 is replaced with salicylic acid in equal amount.

[0087] Performance test

[0088] The soothing acne-relieving sprays prepared in the above examples and comparative examples were subjected to the following tests.

[0089] 1. Toxicity test

[0090] The soothing acne-relieving sprays prepared in the above examples and comparative examples were respectively sprayed on the backs of mice with 2×2 cm 2 of fur removed and a 1 cm wound. 10 mice were used in each group, and they were sprayed 2 times a day, with 0.5 mL applied each time. After spraying, they were covered with a low-allergenic tape and continuously sprayed and observed for 2 weeks. No death or abnormal toxic reaction was observed in each group of mice, and their diet and vital activities were normal; three months after stopping the application, there was no abnormal performance in each group of mice, they were lively, had normal diet, and there were no significant differences in the randomly selected blood picture, biochemical indexes, urine routine indexes and organ coefficients, indicating that the acne-relieving spray prepared by the present invention is non-toxic.

[0091] 2. Antibacterial test against Propionibacterium acnes

[0092] According to the "Hygiene Standard for Cosmetics" 2015 edition, the operation methods of culture medium preparation, bacterial liquid preparation and inoculation method were used to conduct the antibacterial test against Propionibacterium acnes on the sprays prepared in each experimental example and comparative example, and the antibacterial rate was tested.

[0093] 3. Volunteer experiment

[0094] 3.1 Irritation test

[0095] The human patch test was used for testing. Subjects: A total of 35 people, including 9 males and 26 females, aged 15 - 40 years old, meeting the volunteer selection criteria for subjects;

[0096] Test method: The closed test method was adopted. The acne-relieving sprays prepared in the above examples and comparative examples were placed in a suitable patch tester, and it was applied to the flexor side of the subject's arm with a low-allergenic tape, and gently pressed with the palm to make it evenly adhere to the skin for 24 h; the blank control group was that the subjects did not use the product;

[0097] Observation results: The test devices were removed after 24 hours respectively, and the skin reactions were observed at 0.5h, 24h, and 48h. The reaction results were recorded. After the test, all volunteers showed negative reactions. The grades of skin adverse reactions are shown in Table 1.

[0098] Table 1

[0099]

[0100]

[0101] 3.2. Acne-removing effect test

[0102] The selected test population was aged 15 - 35 years old, with 10 people in each group, half male and half female, having obvious acne and pimples on the face, meeting the volunteer selection criteria for the subjects. It was used 2 times a day. When using, Agent A and Agent B were sprayed on the affected area in sequence, 0.5 ml of each of Agent A and Agent B was used each time, and it was used continuously for 14 days. During the test process, no other skin care products or hormonal products were used. Through follow-up visits to the testers, a sebum test analyzer Sebumeter SM815 (Courage Khazaka, Germany) was used to detect the sebum values before use and after 14 days of use, and the reduction value of the sebum value was recorded. The reduction value of the sebum value = the sebum value before use - the sebum value after 14 days of use, and whether there was a stinging sensation when the volunteers used it for the first time was recorded. In addition, the number of people without acne marks after continuous use for one month in the test population was recorded.

[0103] The test results are shown in Table 2.

[0104] Table 2

[0105]

[0106] From the comparison of the data in Examples 1 - 3 in Table 2, it can be seen that the soothing acne-removing spray obtained by the present invention has good antibacterial and sebum inhibitory properties; from the comparison between Example 4 and Example 1, it can be seen that changing the ratio of phospholipids to olive oil may affect the water-oil balance of the skin, and both the antibacterial and sebum inhibitory properties of the acne-removing spray decrease; from the comparison between Example 5 and Example 1, it can be seen that changing the ratio of salicylic acid to the shell layer raw material may cause the release of salicylic acid to slow down, and the sebum inhibitory and antibacterial properties decrease; from the comparison between Examples 6 and 7 and Example 1, it can be seen that changing the ratio of molecular sieve to acrylic acid and the ratio of acrylic acid-modified molecular sieve to choline chloride may cause the weakening of the interaction force with the active ingredients in tangerine peel, resulting in a decrease in the extraction rate and a decrease in the sebum inhibitory property; from the comparison between Example 8 and Example 1, it can be seen that directly using molecular sieve to extract tangerine peel has a low extraction rate, a decrease in anti-inflammatory property, and both the sebum inhibitory and antibacterial properties decrease; from the comparison between Comparative Example 1 and Example 1, it can be seen that when using salicylic acid, the drug utilization rate is low, and both the sebum inhibitory and antibacterial properties decrease.

[0107] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Although the present invention has been disclosed above with the preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to equivalent embodiments by using the disclosed technical content within the scope of the technical solution of the present invention. However, as long as it does not depart from the content of the technical solution of the present invention, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A soothing and anti-acne spray, characterized in that: The invention comprises an agent A and an agent B; the agent A comprises the following raw materials, calculated by 100% by mass: 2-3% moisturizer, 1-1.5% penetrant, 0.1-0.2% salicylic acid microcapsule, 0.1-0.2% preservative, 0.6-0.8% regulator, 0.05-0.15% buffer, 1.5-1.8% plant extract, and the balance is deionized water; the agent B comprises the following raw materials, calculated by 100% by mass: 10-12% chloramphenicol, and the balance is solvent.

2. The soothing and anti-acne spray according to claim 1, characterized in that: The preparation method of the salicylic acid microcapsules comprises the following steps: (1) adding phospholipids, menthyl lactate and olive oil to deionized water, adjusting the pH to 9-11, reacting at 40-50° C. for 1-3 h, and rotary evaporating to obtain a shell material; (2) adding xanthan gum and sodium cocoyl glycinate to propylene glycol to obtain an alcohol phase; (3) adding salicylic acid and the shell material obtained in step (1) to the alcohol phase obtained in step (2), and then adding deionized water, pre-homogenizing at 70-80° C. for 10-15 min, and then homogenizing at 80-100 MPa, and repeating for 2-3 times to obtain salicylic acid microcapsules.

3. The soothing and anti-acne spray according to claim 2, characterized in that: The mass ratio of phospholipid to olive oil in step (1) is 1:(0.6-0.9).

4. The soothing and anti-acne spray according to claim 2, characterized in that: The mass ratio of salicylic acid to shell raw material in step (3) is 1:(18-22).

5. The soothing and anti-acne spray according to claim 1, characterized in that: The plant extracts are baraba extract, hawthorn leaf extract and tangerine peel extract, and the mass ratio of the three is (0.6-0.8): (0.4-0.6):

1.

6. The soothing and anti-acne spray according to claim 5, characterized in that: The preparation method of the tangerine peel extract comprises the following steps: crushing tangerine peel to obtain tangerine peel powder, grinding the tangerine peel powder and modified molecular sieve for 2-3 minutes, filling a solid phase extraction column, eluting with an eluent, collecting the eluate, centrifuging, taking the supernatant, and drying to obtain the tangerine peel extract.

7. The soothing and anti-acne spray according to claim 6, characterized in that: The preparation method of the modified molecular sieve comprises the following steps: 1) Add molecular sieve and KH570 to ethanol, react at 50-60°C for 5-6h, then add acrylic acid and azobisisobutyronitrile, and continue to react for 1-2h to obtain acrylic acid modified molecular sieve; 2) Adding the acrylic acid modified molecular sieve obtained in step 1), choline chloride and phosphoric acid into DMF, reacting at 70-80° C. for 4-5 hours, filtering, washing and drying to obtain the modified molecular sieve.

8. The soothing and anti-acne spray according to claim 7, characterized in that: The mass ratio of the molecular sieve to acrylic acid in step 1) is 1:(0.5-0.7).

9. The soothing and anti-acne spray according to claim 7, characterized in that: The mass ratio of the acrylic acid modified molecular sieve to choline chloride in step 2) is 1:(0.7-0.9).

10. Use of the soothing and anti-acne spray according to any one of claims 1 to 9, characterized in that: Spray the A and B agents on the affected area in sequence.

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