Cross-linked sodium hyaluronate gel preparation system

Abstract

The invention discloses a cross-linked sodium hyaluronate gel preparation system, and belongs to the technical field of biological medicine equipment. When the cross-linked sodium hyaluronate gel is prepared, a material A and a material B are stored in two storage tanks respectively, a driving motor drives a linkage gear box, the linkage gear box synchronously drives two stirring rollers, the two stirring rollers mix and stir the material A and the material B, a mixed material is obtained after stirring and enters a finished product material collecting bin from a butt joint pipe, and the finished product material collecting bin is used for collecting the cross-linked sodium hyaluronate gel. The electric heating layer is used for heating the material storage tank, so that the heat of the materials in the material storage tank is increased, and the gelatinous materials can flow better and can be mixed better subsequently; a stirring block is matched with a spiral sheet for use, so that the material stirring efficiency is improved by the stirring block; and the electric heating rod conducts heat to the stirring roller, so that the stirring roller is heated, and the heated stirring roller can improve the fluidity of the materials, so that the materials are better mixed and stirred.

Description

Technical Field

[0001] The invention belongs to the technical field of biomedical equipment, and in particular relates to a preparation system of cross-linked sodium hyaluronate gel. Background Art

[0002] Cross-linked hyaluronic acid is a commonly used polymer material, widely used in cosmetic fillers, anti-adhesion, hemostasis, ophthalmic viscoelastics and other fields.

[0003] In the production and preparation of cross-linked hyaluronic acid gel, it is necessary to mix and stir the various prepared raw materials. The existing process is to place the materials to be mixed in a stirring tank and then stir them with a stirring rod to make them mixed. However, after mixing and stirring in the stirring tank, it is very troublesome to take out the mixture.

[0004] To this end, the applicant has conducted useful explorations and attempts and found solutions to the above problems. The technical solutions to be introduced below were produced in this context. Summary of the invention

[0005] The present invention mainly solves the technical problems existing in the above-mentioned prior art and provides a preparation system of cross-linked sodium hyaluronate gel.

[0006] The above technical problems of the present invention are mainly solved by the following technical solutions: a cross-linked sodium hyaluronate gel preparation system, comprising a material storage system and a stirring system arranged below the material storage system, the material storage system comprising two material storage tanks and a material delivery pipe arranged at the bottom of the material storage tanks, a system base is arranged at the lower side of the stirring system, the two material storage tanks are arranged on the system base through a support frame, and the stirring system is arranged on the upper side of the middle part of the system base;

[0007] The stirring system includes a driving motor, a linkage gear box and a stirring bin, wherein two stirring rollers are arranged in the stirring bin, and both ends of the two stirring rollers are rotatably connected to the front and rear sides of the stirring bin, the driving motor is transmission-connected to the linkage gear box, and the linkage gear box is transmission-connected to the two stirring rollers, so that the two stirring rollers rotate in opposite directions, the lower end outlets of the two feeding pipes are arranged at the front end of the stirring bin, and a discharge port is arranged on the lower side of the rear end of the stirring bin, and a finished material collection bin is detachably arranged on the inner side of the system base, and the discharge port is connected to the finished material collection bin by a butt pipe.

[0008] Preferably, an electric heating layer is provided on the outer walls of the two storage tanks.

[0009] Preferably, both of the two feed pipes are provided with solenoid valves.

[0010] Preferably, several silo covers are detachably laid on the upper side of the mixing silo. Two pipe holes are opened on the silo cover located on the upper side of the front end of the mixing silo, and the lower ends of the two feeding pipes are respectively inserted into the pipe holes.

[0011] Preferably, a stabilizing bracket is arranged on the lower sides of the driving motor, the linkage gearbox and the mixing silo, and the stabilizing bracket is installed on the system base.

[0012] Preferably, spiral blades are spirally arranged on both of the two mixing rolls.

[0013] Preferably, several mixing blocks are arranged on the mixing roll at intervals between the spiral blades.

[0014] Preferably, heating holes are opened inside the mixing roll, electric heating rods are arranged in the heating holes, bearings are sleeved at both ends of the electric heating rods, the two bearings are respectively arranged on both sides inside the heating holes, a lead hole is opened at the front end of the mixing roll, and the power supply wires of the electric heating rods are led outwards from the lead hole.

[0015] The beneficial effects of the present invention are as follows:

[0016] 1. When preparing cross-linked sodium hyaluronate gel, material A and material B are respectively stored in two storage tanks. Material A and material B enter the feeding pipes by their own weights. The two feeding pipes lead material A and material B into the mixing silo. The driving motor drives the linkage gearbox, and the linkage gearbox synchronously drives the two mixing rolls. The two mixing rolls mix and stir material A and material B, and stir and convey them towards the discharge port. After stirring, the mixed material is obtained and enters the finished material collection silo through the docking pipe. By controlling the positive and negative rotations of the driving motor, the back-and-forth stirring of the material is realized, so that it can be better mixed. The mixing silo is arranged as a long rectangular chamber, so that the effect of full mixing and stirring can be achieved during the conveying process;

[0017] 2. The electric heating layer heats the storage tank, improves the temperature of the material in the storage tank, ensures that the gel-like material can flow better, and can be better mixed subsequently. The conveying amount of the feeding pipe is controlled by the solenoid valve to realize better control of the ratio of the mixed material;

[0018] 3. The spiral blades on the two mixing rolls enable the material to be fully stirred, and can stir and convey the material along the axis direction of the mixing roll while stirring. The mixing blocks are used in cooperation with the spiral blades, and the mixing blocks increase the stirring efficiency of the material;

[0019] 4. Since bearings are arranged at both ends of the electric heating rod, when the mixing roll rotates, the electric heating rod can be prevented from rotating along with the electric heating rod due to the pulling of the power supply wire, and the electric heating rod can still conduct heat to the mixing roll to make the mixing roll heat up. The heated mixing roll can improve the fluidity of the material and make it better mixed and stirred. Description of the Drawings

[0020] Figure 1 is a front view structural schematic diagram of the present invention;

[0021] Figure 2 is a top view structural schematic diagram of the present invention;

[0022] Figure 3 is a side view structural schematic diagram of the present invention;

[0023] Figure 4 is a structural schematic diagram of the present invention with some bin covers removed;

[0024] Figure 5 is a structural schematic diagram of the stirring roller of the present invention;

[0025] Figure 6 is an internal structural schematic diagram of the stirring roller of the present invention.

[0026] In the figure: 1. Storage tank; 2. Feeding pipe; 3. System base; 4. Support frame; 5. Driving motor; 6. Linkage gearbox; 7. Stirring bin; 8. Stirring roller; 9. Discharge port; 10. Finished product collection bin; 11. Docking pipe; 12. Electric heating layer; 13. Solenoid valve; 14. Bin cover; 15. Pipe hole; 16. Stable support; 17. Spiral blade; 18. Stirring block; 19. Heating hole; 20. Electric heating rod; 21. Bearing; 22. Lead hole. Specific embodiments

[0027] The following is further specifically described for the technical solution of the present invention through examples and in combination with the attached Figures 1-6 structural diagram.

[0028] Example 1: A cross-linked sodium hyaluronate gel preparation system, comprising a storage system and a stirring system arranged below the storage system. The storage system includes two storage tanks 1 and a feeding pipe 2 arranged at the bottom of the storage tank 1. A system base 3 is arranged on the lower side of the stirring system. The two storage tanks 1 are arranged on the system base 3 through a support frame 4. The stirring system is arranged on the upper side of the middle of the system base 3;

[0029] The stirring system includes a driving motor 5, a linkage gearbox 6 and a stirring bin 7. Two stirring rollers 8 are arranged in the stirring bin 7. Both ends of the two stirring rollers 8 are rotatably connected to the front and rear sides of the stirring bin 7. The driving motor 5 is drivingly connected to the linkage gearbox 6, and the linkage gearbox 6 is drivingly connected to the two stirring rollers 8, so that the two stirring rollers 8 rotate in opposite directions. The lower outlet parts of the two feeding pipes 2 are arranged at the front end of the stirring bin 7. A discharge port 9 is arranged on the lower side of the rear end of the stirring bin 7. A finished product collecting bin 10 is detachably arranged inside the system base 3. The discharge port 9 is connected to the finished product collecting bin 10 through a docking pipe 11.

[0030] The specific implementation method is as follows:

[0031] When preparing the cross-linked sodium hyaluronate gel, the material A and the material B are respectively stored in two storage tanks 1. The material A and the material B enter the feeding pipes 2 by their own weights. The two feeding pipes 2 introduce the material A and the material B into the stirring bin 7. The driving motor 5 drives the linkage gearbox 6, and the linkage gearbox 6 synchronously drives the two stirring rollers 8. The two stirring rollers 8 mix and stir the material A and the material B, and stir and convey them towards the discharge port 9. After stirring, the mixed material is obtained and enters the finished product collecting bin 10 through the docking pipe 11. By controlling the forward and reverse rotation of the driving motor 5, the back-and-forth stirring of the material is realized, so that it can be better mixed. The stirring bin 7 is arranged as a long rectangular chamber, so that it can be fully mixed and stirred during the conveying process.

[0032] Embodiment 2:

[0033] In this embodiment, on the basis of Embodiment 1, it is further limited that a layer of electric heating layer 12 is arranged on the outer walls of the two storage tanks 1. The electric heating layer 12 heats the storage tanks 1 to increase the temperature of the materials in the storage tanks 1, ensure that the gel-like materials can flow better, and can be better mixed subsequently.

[0034] Other parts of this embodiment are the same as those of the above Embodiment 1 and will not be described in detail.

[0035] Embodiment 3:

[0036] In this embodiment, on the basis of Embodiment 1, it is further limited that electromagnetic valves 13 are arranged on both of the two feeding pipes 2. The conveying amount of the feeding pipes 2 is controlled through the electromagnetic valves 13 to better control the ratio of the mixed material.

[0037] Other parts of this embodiment are the same as those of the above Embodiment 1 and will not be described in detail.

[0038] Embodiment 4:

[0039] On the basis of Embodiment 1, this embodiment further defines that several bin covers 14 are detachably laid on the upper side of the mixing bin 7. Two pipe holes 15 are provided on the bin cover 14 at the front upper part of the mixing bin 7. The lower ends of the two feeding pipes 2 are respectively inserted into the pipe holes 15. The several bin covers 14 can enclose the upper side of the mixing bin 7 to prevent the materials from leaking during mixing. Moreover, only by removing one of the bin covers 14 can the internal situation of the mixing bin 7 be observed.

[0040] Other parts of this embodiment are the same as those of Embodiment 1 above and will not be elaborated here.

[0041] Embodiment 5:

[0042] On the basis of Embodiment 1, this embodiment further defines that a stabilizing bracket 16 is provided on the lower sides of the driving motor 5, the linkage gearbox 6 and the mixing bin 7. The stabilizing bracket 16 is installed on the system base 3. The stabilizing bracket 16 supports and holds up the driving motor 5, the linkage gearbox 6 and the mixing bin 7, which improves the operating stability and facilitates later maintenance and repair.

[0043] Other parts of this embodiment are the same as those of Embodiment 1 above and will not be elaborated here.

[0044] Embodiment 6:

[0045] On the basis of Embodiment 1, this embodiment further defines that spiral blades 17 are spirally arranged on both of the two mixing rollers 8. The spiral blades 17 on the two mixing rollers 8 enable the materials to be fully mixed and can convey the materials while mixing along the axial direction of the mixing rollers 8.

[0046] Other parts of this embodiment are the same as those of Embodiment 1 above and will not be elaborated here.

[0047] Embodiment 7:

[0048] On the basis of Embodiment 6, this embodiment further defines that several mixing blocks 18 are arranged at intervals between the spiral blades 17 on the mixing roller 8. The mixing blocks 18 cooperate with the spiral blades 17, and the mixing blocks 18 increase the mixing efficiency of the materials.

[0049] Other parts of this embodiment are the same as those of Embodiment 6 above and will not be elaborated here.

[0050] Embodiment 8:

[0051] On the basis of Embodiment 7, this embodiment further defines that a heating hole 19 is provided inside the stirring roller 8, an electric heating rod 20 is arranged in the heating hole 19, bearings 21 are sleeved at both ends of the electric heating rod 20, and the two bearings 21 are respectively arranged on both sides inside the heating hole 19. A lead hole 22 is provided at the front end of the stirring roller 8, and the power cord of the electric heating rod 20 is led outwards from the lead hole 22;

[0052] Since bearings are provided at both ends of the electric heating rod 20, when the stirring roller 8 rotates, the electric heating rod 20 can be prevented from rotating along with it due to the pulling of the power cord, while the electric heating rod 20 can still conduct heat to the stirring roller 8, causing the stirring roller 8 to heat up. The heated stirring roller 8 can improve the fluidity of the material, making it better mixed and stirred.

[0053] Other parts of this embodiment are the same as those of Embodiment 7 above and will not be elaborated here.

[0054] The working principle of the present invention:

[0055] When preparing cross-linked sodium hyaluronate gel, Material A and Material B are respectively stored in two storage tanks 1. The electric heating layer 12 heats the storage tanks 1 to increase the temperature of the materials in the storage tanks 1, ensuring that the gel-like materials can flow better. Material A and Material B enter the feeding pipes 2 by their own weight. The two feeding pipes 2 introduce Material A and Material B into the stirring chamber 7. The solenoid valve 13 controls the feeding volume of the feeding pipes 2 to better control the ratio of the mixed materials. The driving motor 5 drives the linkage gearbox 6, and the linkage gearbox 6 synchronously drives the two stirring rollers 8. The two stirring rollers 8 mix and stir Material A and Material B and convey them towards the discharge port 9 while stirring. The spiral blades 17 on the two stirring rollers 8 enable the materials to be fully stirred and can be conveyed while stirring along the axial direction of the stirring rollers 8. The stirring blocks 18 cooperate with the spiral blades 17 to increase the stirring efficiency of the materials. The electric heating rod 20 conducts heat to the stirring roller 8, causing the stirring roller 8 to heat up. The heated stirring roller 8 can improve the fluidity of the materials, making it better mixed and stirred. After stirring, the mixed materials enter the finished product collecting bin 10 through the docking pipe 11. By controlling the forward and reverse rotation of the driving motor 5, the materials can be stirred back and forth to make them better mixed. The stirring chamber 7 is set as a long rectangular chamber, enabling it to be fully mixed and stirred during the conveying process.

[0056] Finally, it should be noted that the above embodiments are only relatively representative examples of the present invention. Obviously, the present invention is not limited to the above embodiments and can have many variations. Any simple modification, equivalent change, and modification made to the above embodiments based on the technical essence of the present invention should be considered to fall within the protection scope of the present invention.

Claims

1. A cross-linked sodium hyaluronate gel preparation system, comprising a storage system and a stirring system disposed below the storage system. Characterized in that The storage system includes two storage tanks (1) and a feed pipe (2) disposed at the bottom of the storage tank (1). A system base (3) is provided on the lower side of the stirring system. The two storage tanks (1) are disposed on the system base (3) through a support frame (4), and the stirring system is disposed on the upper side of the middle of the system base (3). The stirring system includes a driving motor (5), a linkage gearbox (6) and a stirring chamber (7). Two stirring rollers (8) are disposed in the stirring chamber (7). The two ends of the two stirring rollers (8) are rotatably connected to the front and rear sides of the stirring chamber (7). The driving motor (5) is in transmission connection with the linkage gearbox (6), and the linkage gearbox (6) is in transmission connection with the two stirring rollers (8) to make the two stirring rollers (8) rotate in opposite directions. The lower end outlets of the two feed pipes (2) are disposed at the front end of the stirring chamber (7). An outlet (9) is provided on the lower side of the rear end of the stirring chamber (7). A finished product collection bin (10) is detachably disposed inside the system base (3). The outlet (9) is connected to the finished product collection bin (10) through a docking pipe (11).

2. The cross-linked sodium hyaluronate gel preparation system according to claim 1, Characterized in that A layer of electric heating layer (12) is provided on the outer walls of the two storage tanks (1).

3. The cross-linked sodium hyaluronate gel preparation system according to claim 1, Characterized in that Electromagnetic valves (13) are provided on both of the two feed pipes (2).

4. The cross-linked sodium hyaluronate gel preparation system according to claim 1, Characterized in that A plurality of bin cover plates (14) are detachably laid on the upper side of the stirring chamber (7). Two pipe holes (15) are opened on the bin cover plate (14) located on the upper side of the front end of the stirring chamber (7). The lower ends of the two feed pipes (2) are respectively inserted into the pipe holes (15).

5. The cross-linked sodium hyaluronate gel preparation system according to claim 1, Characterized in that A stabilizing bracket (16) is provided on the lower sides of the driving motor (5), the linkage gearbox (6) and the stirring chamber (7). The stabilizing bracket (16) is installed on the system base (3).

6. The cross-linked sodium hyaluronate gel preparation system according to claim 1, Characterized in that Spiral sheets (17) are spirally provided on both of the two stirring rollers (8).

7. The cross-linked sodium hyaluronate gel preparation system according to claim 6, Characterized in that A plurality of stirring blocks (18) are provided on the stirring roller (8) at intervals between the spiral sheets (17).

8. The cross-linked sodium hyaluronate gel preparation system according to claim 7, Characterized in that A heating hole (19) is formed in the inner side of the stirring roller (8), an electric heating rod (20) is arranged in the heating hole (19), bearings (21) are sleeved at both ends of the electric heating rod (20), the two bearings (21) are respectively arranged on both sides in the heating hole (19), a lead hole (22) is formed in the front end of the stirring roller (8), and the power cord of the electric heating rod (20) is led outwards from the lead hole (22).

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