Oral composition

Abstract

Provided is an oral composition which exhibits excellent retention of fluorine ions (F-) on the tooth surface, in which a decrease in bactericidal power after storage is suppressed, and which exhibits excellent storage stability of the surface appearance (toothpaste surface). An oral composition containing (A) sodium fluoride, (B) a water-soluble calcium salt, (C) condensed phosphoric acid or a salt thereof, (D) one or more substances selected from the group consisting of cetylpyridinium chloride, benzalkonium chloride and chlorhexidine hydrochloride, and (E) a water-soluble polymer compound.

Description

Technical Field

[0001] The present invention relates to an oral composition containing fluoride ions (F - ). Background Art

[0002] Fluorides such as sodium fluoride are widely used as medicinal ingredients (active ingredients) in oral compositions such as dentifrices because of their effect of preventing dental caries. To make the fluorine compound act effectively, it is effective to keep fluoride ions (F - ) retained on the mucosa and tooth surfaces in the oral cavity for a long time, especially on the tooth surfaces. It is desired that a relatively large amount of fluoride ions remain in the oral cavity even after rinsing the mouth with water or the like after use.

[0003] As a method for improving the retention of fluoride ions, a method of combining a water-soluble polyphosphate, a water-soluble calcium salt, and sodium fluoride to form a complex is also employed. However, when a cationic bactericide is made to coexist for the purpose of imparting bactericidal power, it reacts with the complex, and the retention of fluoride ions and the bactericidal power after long-term storage decrease.

[0004] Patent Document 1 (Japanese Patent No. 6471667) proposes a liquid oral composition composed of a combination of a fluoride salt, calcium glycerophosphate, condensed phosphoric acid, and a cationic bactericide. By mixing with this combination, an excellent effect of promoting remineralization and a persistent high bactericidal effect against cariogenic pathogens are achieved. However, there is a problem that the bactericidal effect decreases after long-term storage.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Problems to be Solved by the Invention

[0006] The present invention has been completed in view of the above circumstances, and an object thereof is to provide an oral composition that has excellent retention of fluoride ions (F - ) on tooth surfaces, suppresses a decrease in bactericidal power after storage, and has excellent storage stability of the surface appearance (toothpaste surface).

Means for Solving the Problems

[0007] In order to achieve the above object, the present inventors conducted intensive studies and found that the above problems can be solved by using (A) sodium fluoride, (B) a water-soluble calcium salt, (C) condensed phosphoric acid or its salt, (D) one or more selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) a water-soluble polymer compound, thereby completing the present invention.

[0008] Therefore, the present invention provides an oral composition. 1. An oral composition comprising: (A) Sodium fluoride, (B) A water-soluble calcium salt, (C) A condensed phosphoric acid or its salt, (D) One or more selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) A water-soluble polymer compound. 2. The oral composition according to 1, wherein the component (B) is one or more selected from calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate. 3. The oral composition according to 1 or 2, wherein the component (C) is one or more selected from pyrophosphoric acid and its alkali metal salts. 4. The oral composition according to any one of 1 to 3, wherein the viscosity of a 2% by mass aqueous solution of the component (E) at 25 °C is 400 mPa·s or more. 5. The oral composition according to any one of 1 to 4, wherein the component (E) is one or more selected from sodium polyacrylate, xanthan gum, sodium carboxymethylcellulose, sodium alginate, carrageenan, hydroxyethyl cellulose, and polyvinylpyrrolidone. 6. The oral composition according to 5, wherein the component (E) is one or more selected from sodium polyacrylate, xanthan gum, sodium carboxymethylcellulose, hydroxyethyl cellulose, and polyvinylpyrrolidone. 7. The oral composition according to any one of 1 to 6, wherein the mixing ratio of the component (B) to the component (D) represented by (D) / (B) is 0.0005 to 1.2 in terms of molar ratio. 8. The oral composition according to any one of 1 to 7, wherein the mixing ratio of the component (D) to the component (E) represented by (E) / (D) is 0.5 to 200 in terms of mass ratio.

Advantages of the Invention

[0009] According to the present invention, an oral composition can be provided in which the retention of fluoride ions (F - ) on the tooth surface is excellent, the reduction of bactericidal power after storage is suppressed, and the storage stability of the surface appearance (toothpaste surface) is excellent. Detailed Description of the Invention

[0010] The present invention will be described in detail below. The present invention is an oral composition comprising: (A) Sodium fluoride, (B) A water-soluble calcium salt, (C) Condensed phosphoric acid or its salts, (D) One or more selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and (E) A water-soluble polymer compound.

[0011] [Component (A)] Component (A) of the present invention is sodium fluoride, which is a source of fluoride ions. The mixing amount of component (A) is preferably 0.09 to 1.3% (mass%, the same hereinafter) of the whole composition, more preferably 0.10 to 1.1%. By setting it to 0.09% or more, the retention of fluoride ions (F - ) on the tooth surface is further improved. When it is more than 1.3%, the storage stability of curing, liquid separation, toothpaste surface, etc. (hereinafter sometimes only referred to as storage stability) may deteriorate.

[0012] [Component (B)] Component (B) of the present invention is a water-soluble calcium salt, and one kind or two or more kinds can be used alone in combination. Examples of the water-soluble calcium salt include calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate. Among them, calcium chloride, calcium gluconate, calcium lactate, and calcium glycerophosphate are preferred.

[0013] The mixing amount of component (B) is preferably 0.02 to 5% of the whole composition, more preferably 0.03 to 3.0%. By setting it within the above range, the retention of fluoride ions (F - ) on the tooth surface and the bactericidal power after storage are further improved. In addition, by setting it to 5% or less, the storage stability is further improved.

[0014] [Component (C)] Component (C) of the present invention is condensed phosphoric acid or its salts, and one kind or two or more kinds can be used alone in combination. Examples of the condensed phosphoric acid include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid; cyclic polyphosphoric acids such as metaphosphoric acid and tetrametaphosphoric acid, and examples of its salts include sodium salts and potassium salts. Among them, pyrophosphoric acid, tripolyphosphoric acid, metaphosphoric acid or its salts are preferred, and especially linear polyphosphates, namely sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, and potassium tripolyphosphate are preferred, and sodium pyrophosphate, potassium pyrophosphate, and sodium tripolyphosphate are more preferred, and pyrophosphoric acid and its alkali metal salts, namely sodium pyrophosphate and potassium pyrophosphate, are further preferred.

[0015] The mixing amount of component (C) is preferably 0.02 to 3.0% of the whole composition, more preferably 0.03 to 1.3%. By setting it to 0.02% or more, the retention of fluoride ions (F - ) on the tooth surface and the bactericidal power after storage are further improved. In addition, by setting it to 3.0% or less, the decrease in the bactericidal power after storage is further suppressed.

[0016] [(D) component] The (D) component of the present invention is one or more selected from cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride, and two of them can also be used in combination. These are components known as cationic bactericides. By using these components, while the retention of fluoride ions (F - ) on the tooth surface is excellent, the reduction of bactericidal power after storage is also suppressed. For example, when benzethonium chloride other than the above is mixed, the retention of fluoride ions (F - ) on the tooth surface becomes insufficient (Comparative Example 5). Among them, cetylpyridinium chloride, benzalkonium chloride, and chlorhexidine hydrochloride are preferred, and cetylpyridinium chloride and benzalkonium chloride are more preferred.

[0017] The mixing amount of the (D) component is preferably 0.004 to 0.2% of the whole composition, and more preferably 0.005 to 0.1%. By setting it to 0.004% or more, the reduction of bactericidal power after storage is more sufficiently suppressed. By setting it to 0.2% or less, the reduction of bactericidal power after storage is more suppressed, and the storage stability is further improved.

[0018] [(E) component] The (E) component of the present invention is a water-soluble polymer compound, and one kind or a combination of two or more kinds can be used alone to improve the retention of fluoride ions on the tooth surface, suppress the reduction of bactericidal power after storage, and improve the storage stability. As the (E) component, for example, sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, sodium alginate, carrageenan, hydroxyethyl cellulose, and polyvinylpyrrolidone can be mentioned. Among them, sodium polyacrylate, xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, and polyvinylpyrrolidone are preferred.

[0019] The viscosity of the 2% by mass aqueous solution of the (E) component at 25°C is preferably 400 mPa·s or more, more preferably 400 to 150,000 mPa·s, and further preferably 400 to 100,000 mPa·s. The viscosity is measured using a BH type Brookfield viscometer under the conditions of 20°C and a measurement time of 1 minute. The rotor No. and rotation speed are as follows. ·When the viscosity of the 2% aqueous solution is 400 to 500 mPa·s: Rotor No. 1, rotation speed 20 rpm ·When the viscosity of the 2% aqueous solution is greater than 500 mPa·s and 2,000 mPa·s or less: Rotor No. 2, rotation speed 20 rpm ·When the viscosity of the 2% aqueous solution is greater than 2,000 mPa·s and 5,000 mPa·s or less: Rotor No. 3, rotation speed 20 rpm ·When the viscosity of the 2% aqueous solution is greater than 5,000 mPa·s and 10,000 mPa·s or less: Rotor No. 4, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution is greater than 10,000 mPa·s and less than 20,000 mPa·s: Rotor No. 5, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution is greater than 20,000 mPa·s and less than 50,000 mPa·s: Rotor No. 6, rotation speed 20 rpm · When the viscosity of the 2% aqueous solution is greater than 50,000 mPa·s and less than 200,000 mPa·s: Rotor No. 7, rotation speed 20 rpm

[0020] (E) The mixing amount of the component is preferably 0.05 to 3.0% of the whole composition, more preferably 0.06 to 2.8%, and further preferably 0.1 to 2.0%. By setting it to 0.05% or more, the decrease in bactericidal power after storage is more suppressed, and the storage stability is further improved. On the other hand, when it is greater than 3.0%, the extrudability may deteriorate due to the increase in the viscosity of the preparation.

[0021] In the present invention, it is more preferable that the mixing ratio of the (B) component and the (D) component is within an appropriate range. The mixing ratio of the (B) component and the (D) component represented by (D) / (B) is preferably 0.0005 to 1.2 in terms of molar ratio, more preferably 0.0010 to 0.4, and further preferably 0.0020 to 0.21. By setting it within this range, the retention of fluoride ions (F - ) on the tooth surface is further improved, and the decrease in bactericidal power after storage is more suppressed.

[0022] In the present invention, it is more preferable that the mixing ratio of the (D) component and the (E) component is within an appropriate range. The mixing ratio of the (D) component and the (E) component represented by (E) / (D) is preferably 0.5 to 200 in terms of mass ratio, more preferably 2 to 150, and further preferably 5 to 140. By setting it within this range, the retention of fluoride ions (F - ) on the tooth surface is further improved, and the decrease in bactericidal power after storage is more suppressed.

[0023] [Oral composition] The oral composition of the present invention can be made into solid, solid matter, liquid, liquid state, gel, paste, colloidal state, etc., and can be made into various dosage forms such as toothpaste, liquid dentifrice, liquid dentifrice, tooth wet-powder, oral cleanser, mouthwash, tablets, chewing gum, etc. Its manufacturing method can also adopt conventional methods according to the dosage form. Among them, dentifrice is preferred, and toothpaste is preferred. In addition, the present invention is not an article that mixes two agents during use, but an oral composition in which the components (A) to (E) are mixed into one composition.

[0024] As an optional component, there is no particular limitation, and components used in the oral composition can be mixed within the range and amount that do not impair the effects of the present invention. For example, surfactants, thickeners (humectants), binders, sweeteners, colorants, fragrances, active ingredients, pH adjusters, solvents, etc. other than components (A) to (E) can be mentioned.

[0025] As optional surfactants, anionic surfactants, nonionic surfactants, and amphoteric surfactants can be mixed. Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, acyl sarcosinates, acyl taurates, and acyl amino acid salts. Examples of nonionic surfactants include sugar fatty esters such as sucrose fatty acid esters, sugar alcohol fatty acid esters, sorbitan fatty acid esters, glycerol fatty acid esters, polyglycerol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alcohol ethers, and fatty acid alkanolamides. Examples of amphoteric surfactants include acetic acid betaine types such as alkyl betaines and fatty acid amide propyl betaines, and imidazolinium betaine (alkyl imidazole) types such as alkyl imidazolinium betaines and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaines.

[0026] When mixing surfactants, the mixing amount is preferably 0.001 to 10% of the whole composition, more preferably 0.1 to 8%.

[0027] As thickeners (humectants), sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as glycerol and propylene glycol can be mentioned. When mixing humectants, the mixing amount is preferably 10 to 90% of the whole composition, preferably 12 to 85%, more preferably 15 to 80%.

[0028] As binders, inorganic binders such as gelling (thickening) silica and gelling (thickening) aluminum silicate can be mentioned. The amount when mixing binders is preferably 0.1 to 10% of the whole composition, more preferably 0.5 to 8%.

[0029] As sweeteners, saccharin, sodium saccharin, sucralose, stevioside, aspartame, sucrose, fructose, etc. can be mentioned.

[0030] As colorants, highly safe water-soluble pigments such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, etc. can be mentioned.

[0031] As spices, natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, oregano oil, lemon oil, nutmeg oil, lavender oil, paracress oil, etc. can be cited. Spice components contained in the above natural essential oils such as L-menthol, carvone, cinnamaldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, paracressin, etc. can be cited. Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furanone, maltol, ethyl maltol, γ / δ-decalactone, γ / δ-undecalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate. Further, blended flavoring essences such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat grape, wine, cherry, squash, coffee, brandy, yogurt, etc. composed of several spice components and natural essential oils can be cited. When mixing the blended spices, the amount thereof is preferably 0.00001 to 3% of the whole composition.

[0032] Examples of the active ingredient include known substances commonly blended in oral compositions, such as nonionic bactericides such as isopropylmethylphenol, anti-inflammatory agents such as tranexamic acid, ε-aminocaproic acid, allantoin, glycyrrhetinic acid, glycyrrhizic acid, etc., enzymes such as dextranase, mutanase, amylase, protease, lysozyme, etc., copper compounds such as copper gluconate, sodium copper chlorophyllin, inorganic salts such as sodium chloride, potassium nitrate, aluminum lactate, zinc chloride, zinc citrate, strontium chloride, vitamins such as ascorbic acid, tocopheryl acetate, pyridoxine, plant extracts such as zeolite, azulene, dihydrocholesterol, chlorophyll, soft extract of Angelica acutiloba, thyme, Scutellaria baicalensis, clove, hamamelis, etc., tartar inhibitors, dental plaque inhibitors. In addition, within the range not interfering with the effects of the present invention, an effective amount of the above active ingredients can be blended.

[0033] Examples of the pH adjuster include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid or their potassium salts, sodium salts, ammonium salts, etc., and sodium hydroxide. The oral composition of the present invention is preferably adjusted to a pH of 5.5 to 9.0 at 25°C. As the pH adjuster in the vicinity of this, a combination of citric acid and sodium citrate is preferably used. As the adjuster, a combination of citric acid and sodium citrate is preferably used.

[0034] Water (balance), lower monohydric alcohols having 1 to 3 carbon atoms such as ethanol can also be blended.

[0035] When used as a dentifrice, an abrasive agent can be mixed. Examples of the abrasive agent include silica-based abrasive agents such as anhydrous silicic acid, precipitated silica, aluminosilicate, and zirconium silicate; calcium phosphate-based compounds such as dicalcium phosphate dihydrate or anhydrate; calcium carbonate; and synthetic resin-based abrasive agents. The amount of the mixed abrasive agent is preferably 2 to 50%, more preferably 5 to 30%.

[0036] The method for producing the oral composition of the present invention is not particularly limited and can be produced by a known method according to the dosage form. For example, it can be produced by mixing components (A) to (E), water, and optional components by a conventional method. The oral composition of the present invention is stored in a common known container according to the dosage form.

Examples

[0037] Examples and comparative examples are shown below to specifically illustrate the present invention, but the present invention is not limited to the following examples. In addition, unless otherwise specified in the following examples, "%" of the components represents mass%, and the amounts of the components in the tables are the amounts converted to the pure components (excluding "sorbitol solution (70%) and cocoamidopropyl betaine solution (30%)").

[0038] [Examples, Comparative Examples] Oral compositions (dentifrice compositions) having the compositions shown in Tables 1 to 6 were prepared by a conventional method and evaluated by the following methods. The results are also shown in the tables.

[0039] (1) Evaluation method for the retention of fluoride ions (F - ) on the tooth surface According to the adsorption test of fluoride ions (F - ) on the tooth root surface, the retention of fluoride ions (F - ) was evaluated. As a test piece, a piece was cut from the tooth root of a bovine tooth and shaped so as to expose the dentin. A 5×5 mm treatment surface was made at the part where the dentin was exposed, and the part other than the treatment surface was covered with nail polish. 20 mL of the oral composition (3-fold dilution based on purified water) was allowed to act on the above dentin block for 3 minutes. Then, while 1 mL of potassium citrate buffer solution was allowed to act on the bovine tooth block, it was stirred for 1 minute to forcibly dissolve the adsorbed and retained fluoride ions (F - ). The concentration of fluoride ions (F - ) contained in the above buffer solution was measured with a fluoride ion (F - ) meter (trade name: Orion11150004-Star, manufactured by Thermo Fisher Scientific Co., Ltd.), and the concentration of the retained fluoride ions (F - ) (ppm) was measured and evaluated according to the following criteria. [Evaluation Criteria] ◎: Fluoride ion (F - ) retention amount is 0.5 ppm or more 〇: Fluoride ion (F - ) retention amount is 0.3 ppm or more and less than 0.5 ppm △: Fluoride ion (F - ) retention amount is 0.1 ppm or more and less than 0.3 ppm ×: Fluoride ion (F - ) retention amount is less than 0.1 ppm

[0040] (2) Evaluation method for bactericidal power after storage Respectively put 50 g of each oral composition into 3 tubes (raw material: the innermost layer is a laminated tube with a diameter of 26 mm made of linear low-density polyethylene (manufactured by Dai Nippon Printing Co., Ltd.)). Store the tubes at 40 °C for 1 month. Then, evaluate the oral composition returned to room temperature by the following tests. [Preparation of bacterial solution] Disperse the cryopreserved Streptococcus mutans (S. mutans 25175) in 4 mL of culture medium (TSB: Toryptic Soy Bloth medium) with a platinum inoculation loop, and culture it at 37 °C under anaerobic conditions for 24 hours. Then, disperse 1 mL of the culture solution in 4 mL of another TSB medium and culture it again at 37 °C under anaerobic conditions for 24 hours. Evaluation of the persistence of bactericidal power against hydroxyapatite (HAP) powder Measure 10 mg of HAP powder into the wells of the first column of a 96-well culture plate (well plate), wash it with 200 μL of 10 mM, pH 7.0 phosphate buffer (PBS), and immerse it in 200 μL of PBS overnight. [Determination of MIC (minimum inhibitory concentration)] After washing the HAP powder treated with PBS twice with 200 μL of PBS, add 150 μL of sterilized saliva, and rotate the wells at a speed of 5 rpm for 30 minutes at room temperature in a sealed state. Remove the saliva, add 100 μL of a 3-fold dilution of the oral composition (diluted with artificial saliva), rotate for another 30 minutes, remove the remaining sample, wash 3 times with 200 μL of PBS, add 200 μL of PBS to the wells containing HAP powder, and add 100 μL of PBS to the other wells. After 1 hour, while stirring, perform a 2-fold serial dilution including the HAP powder, add 100 μL of PBS to each well, further add 10 μL of the above bacterial solution, gently stir, and culture at 37 °C under anaerobic conditions for 24 hours, and determine the MIC (minimum inhibitory concentration) by the naked eye.

[0041] For the oral composition before storage (initial product) and the oral composition after storage at 40°C for 1 month (40°C, 1-month storage product), the MIC was measured respectively, and the maintenance rate of the MIC of the 40°C, 1-month storage product was calculated based on the following formula. Based on the obtained maintenance rate, evaluation was conducted according to the following criteria. Maintenance rate of MIC of 40°C, 1-month storage product = (MIC of storage product) / (MIC of initial product) [Evaluation criteria for bactericidal power after storage] ◎: MIC maintenance rate is less than 1.1 〇: MIC maintenance rate is 1.1 or more and less than 1.15 △: MIC maintenance rate is 1.15 or more and less than 1.2 ×: MIC maintenance rate is 1.2 or more

[0042] (3) Evaluation method for storage stability (toothpaste surface) 50 g of each oral composition was filled into 3 tube containers (material: the innermost layer is a laminated tube with a diameter of 26 mm made of linear low-density polyethylene (manufactured by Dainippon Printing Co., Ltd.)) respectively and stored at 40°C for 1 month. After storage, the dentifrice composition was extruded onto paper from each tube container, and the state of the surface appearance (toothpaste surface) was evaluated according to the following scoring criteria. The average score of the 3 tubes was calculated, and the surface appearance (toothpaste surface) stability of the oral composition was evaluated using the following evaluation criteria. [Scoring criteria] 4 points: The surface of the oral composition has no wrinkles, is shiny, and has no quality problems 3 points: The surface of the oral composition has minute wrinkles and the surface gloss is slightly weak, but it is at a level without quality problems 2 points: Wrinkles can be observed on the surface of the oral composition, the surface has no gloss, and it is at a level with quality problems 1 point: Wrinkles can be clearly observed on the surface of the oral composition, and the surface also has no gloss, and it is at a level with quality problems [Evaluation criteria] ◎: The average score is 4.0 points 〇: The average score is 3.0 points or more and less than 4.0 points. △: The average score is 2.0 points or more and less than 3.0 points. ×: The average score is less than 2.0 points

[0043]

Table 1

[0044]

Table 2

[0045]

Table 3

[0046]

Table 4

[0047]

Table 5

[0048]

Table 6

[0049] The raw materials used in the above examples are as described below. In addition, unless otherwise specified, the amounts of the respective components in the table are the amounts converted to the pure components. Sodium fluoride: manufactured by Stella Chemical Co., Ltd. Calcium chloride: manufactured by Tomita Pharmaceutical Co., Ltd. Calcium gluconate: manufactured by Fuso Chemical Industry Co., Ltd. Calcium lactate hydrate: manufactured by Taihei Chemical Industry Co., Ltd., trade name “Calcium Lactate” Calcium glycerophosphate: manufactured by Iwaki Seika Co., Ltd. Calcium pantothenate: manufactured by BASF Potassium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd. Sodium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd., trade name “Sodium Pyrophosphate (Anhydrous)” Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd. Cetylpyridinium chloride: manufactured by Fujifilm Wako Pure Chemical Corporation Benzalkonium chloride: manufactured by NOF Corporation Sodium polyacrylate: manufactured by Toagosei Co., Ltd., trade name “RHEOGIC 250-H” Xanthan gum: manufactured by DSP Gohsei Food & Chemical Co., Ltd., trade name “MONAT GUM DA” Sodium carboxymethyl cellulose: manufactured by Daicel Fine Chem Co., Ltd., trade name “CMC1260” Sodium alginate: manufactured by Kimica Corporation, trade name “Kimica Algin” Carrageenan: manufactured by Sankyo Co., Ltd., trade name “Carrageenan CF02” Sodium hydroxyethyl cellulose: manufactured by Daicel Fine Chem Co., Ltd., trade name “SE850” Polyvinylpyrrolidone: manufactured by Sumitomo Pharmaceutical Food & Chemical Co., Ltd., trade name “PLASDONEK-90”

Claims

1. An oral composition comprising (A) Sodium fluoride; (B) water-soluble calcium salts; (C) condensed phosphoric acid or its salt; (D) at least one selected from cetylpyridinium chloride, benzalkonium chloride and chlorhexidine hydrochloride; and (E) Water-soluble polymer compound.

2. The oral composition according to claim 1, wherein The component (B) is at least one selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate.

3. The oral composition according to claim 1 or 2, wherein The component (C) is at least one selected from pyrophosphoric acid and alkali metal salts thereof.

4. The oral composition according to claim 1 or 2, wherein The viscosity of a 2 mass % aqueous solution of the component (E) at 25° C. is 400 mPa·s or more.

5. The oral composition according to claim 1 or 2, wherein The component (E) is at least one selected from the group consisting of sodium polyacrylate, xanthan gum, sodium carboxymethylcellulose, sodium alginate, carrageenan, hydroxyethyl cellulose and polyvinyl pyrrolidone.

6. The oral composition according to claim 5, wherein The component (E) is at least one selected from the group consisting of sodium polyacrylate, xanthan gum, sodium carboxymethylcellulose, hydroxyethylcellulose and polyvinyl pyrrolidone.

7. The oral composition according to claim 1 or 2, wherein The mixing ratio of the component (B) to the component (D) represented by (D) / (B) is 0.0005 to 1.2 in terms of molar ratio.

8. The oral composition according to claim 1 or 2, wherein The mixing ratio of the component (D) to the component (E) represented by (E) / (D) is 0.5 to 200 in terms of mass ratio.

9. The oral composition according to claim 1 or 2, wherein The blending amount of component (A) is 0.09 to 1.3% of the total composition, the blending amount of component (B) is 0.02 to 5% of the total composition, the blending amount of component (C) is 0.02 to 3.0% of the total composition, the blending amount of component (D) is 0.004 to 0.2% of the total composition, and the blending amount of component (E) is 0.05 to 3.0% of the total composition.

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