Antioxidant moisturizing cosmetic and preparation method thereof

Abstract

The invention discloses an antioxidant moisturizing cosmetic and a preparation method thereof, and relates to the technical field of cosmetics. The preparation method comprises the following steps: firstly, grafting cinnamyl nitrile to vitamin C to prepare a novel antioxidant by utilizing a catalytic conjugate addition reaction of hydroxyl and double bonds; the vitamin C is easy to oxidize in the cosmetic, and the introduction of cinnamyl nitrile can improve the stability of the whole molecule, reduce the oxidation loss of the vitamin C in the storage and use processes, and further enhance the anti-oxidation effect of the cosmetic; grafting long-chain fatty acid to chitosan to prepare modified chitosan, and loading the modified chitosan, squalane and other active ingredients by using liposome to prepare the high-moisturizing factor. The hydrophobic end of the modified chitosan can be combined with lipid substances in the skin to improve the water locking capacity of the skin, meanwhile, the hydrophilic end can be exposed outside, a large amount of water is combined and kept, and the effects of internal water locking and external water absorption are achieved. The antioxidant moisturizing cosmetic prepared by the invention has the effects of resisting oxidation and moisturizing.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and specifically to an antioxidant and moisturizing cosmetic and a preparation method thereof. Background Art

[0002] The skin is constantly exposed to the external environment, such as pollution and ultraviolet rays, which will continuously generate free radicals, leading to gradual skin aging. Free radicals are by-products of human cell metabolism. When in excess, they will damage unsaturated fatty acids, protein molecules, nucleic acid molecules, extracellular soluble components, and membrane lipids, thus causing problems such as wrinkles, skin sagging, and subcutaneous fat reduction. In addition, free radicals will also damage collagen and elastin fibers, weaken the skin's moisturizing ability and elasticity, and accelerate melanin deposition. With the growth of age and the influence of certain external factors, the free radicals produced in the body may exceed its natural scavenging ability, further exacerbating the damage to skin tissues and promoting the aging process.

[0003] When the water content of the stratum corneum (the outermost layer of the skin) is maintained between 15% and 25%, the skin not only appears soft, smooth, and without fine lines, but also feels more elastic; however, if this ratio drops below 10% due to age growth or improper lifestyle, there will be phenomena such as dryness, increased fine lines, enhanced tightness, and even peeling. Factors such as air conditioner use, environmental pollution, temperature difference pressure brought about by seasonal changes, and the accelerated aging rate of the skin itself will all promote water loss. Therefore, moisturizing has become an essential part of daily skin care.

[0004] In order to maintain the young state of the skin and delay the aging process, it is crucial to take effective moisturizing measures and antioxidant means. Developing cosmetics that can not only efficiently replenish water but also strongly resist the damage of free radicals has extremely high value. Summary of the Invention

[0005] The purpose of the present invention is to provide an antioxidant and moisturizing cosmetic and a preparation method thereof to solve the problems existing in the prior art.

[0006] To solve the above technical problems, the present invention provides the following technical solution: an antioxidant and moisturizing cosmetic, which is composed of a novel antioxidant, a high moisturizing factor, alginate, hydrolyzed collagen, sodium citrate, EDTA-2Na, and purified water.

[0007] Further, the novel antioxidant is prepared by grafting cinnamitrile onto vitamin C by using the catalytic conjugate addition reaction of hydroxyl and double bonds.

[0008] Further, the high moisturizing factor is prepared by acylating long-chain fatty acyl chloride and chitosan to graft long-chain fatty acids onto chitosan to prepare modified chitosan, and then using liposomes to load the modified chitosan and active ingredients.

[0009] Further, the active ingredient includes one or more of squalane, ceramide, and hyaluronic acid.

[0010] Further, a method for preparing an antioxidant and moisturizing cosmetic includes the following preparation steps:

[0011] (1) Mix cinnamaldehyde nitrile and vitamin C at a molar ratio of 1:1.5 - 1.8, add an aqueous ethanol solution of 50 wt% that is 3 - 5 times the mass of cinnamaldehyde nitrile, stir at 200 - 300 r / min for 5 - 8 min, add a catalyst that is 0.04 - 0.06 times the amount of substance of cinnamaldehyde nitrile, add potassium carbonate that is 0.08 - 0.12 times the amount of substance of cinnamaldehyde nitrile, stir at 100 - 150 r / min for 5 - 8 min, introduce nitrogen, raise the temperature to 75 - 80 °C, react for 2.0 - 2.5 h, cool to room temperature, filter to obtain the filtrate, and distill off the solvent to obtain a novel antioxidant;

[0012] (2) Place chitosan in pyridine that is 3 - 4 times its mass for 24 h, dry in a vacuum drying oven at 50 °C and 50 - 60 kPa for 2 - 3 h, add a mixed solution of pyridine and chloroform that is 20 - 25 times the mass of chitosan, add myristoyl chloride that is 1.0 - 1.2 times the amount of substance of chitosan, stir at 400 - 600 r / min for 10 - 15 min, raise the temperature to 60 - 70 °C, react for 8 h, cool to room temperature to obtain a mixed solution, add methanol that is 10 - 15 times the mass of the mixed solution, filter to obtain a crude product of modified chitosan, wash with methanol 3 - 5 times, and dry in a vacuum drying oven at 45 °C and 50 - 60 kPa for 1 - 2 h to obtain modified chitosan;

[0013] (3) Mix egg yolk lecithin, cholesterol, glycerol, and butanediol at a mass ratio of 1:0.5 - 0.6:4 - 6:5 - 8 as phase A, mix an aqueous solution of modified chitosan, an aqueous solution of ceramide, an aqueous solution of squalane, and an aqueous solution of hyaluronic acid at a mass ratio of 1:1.0 - 1.2:1.0 - 1.1:1.0 - 1.2 as phase B, heat phase A and phase B to 75 - 80 °C respectively, stir at 400 - 600 r / min until completely dissolved, keep the temperature of phase A unchanged, increase the rotation speed to 10000 - 12000 r / min, slowly add phase B to phase A, and perform high-pressure homogenization to obtain a high moisturizing factor;

[0014] (4) Mix 1.0 - 1.5 parts of the novel antioxidant, 10 - 15 parts of the high moisturizing factor, 1.5 - 3.5 parts of alginate, 3 - 5 parts of hydrolyzed collagen, 0.5 - 1.5 parts of sodium citrate, 0.01 - 1 part of EDTA - 2Na, and 60 - 75 parts of purified water by weight to prepare the antioxidant and moisturizing cosmetic.

[0015] Further, the catalyst in step (1) is a ruthenium - carbon catalyst.

[0016] Further, the flow rate of nitrogen in step (1) is 10 Nm 3 / h.

[0017] Further, the pyridine and chloroform mixed solution in step (2) is prepared by mixing pyridine and chloroform at a volume ratio of 1:1.

[0018] Further, the concentrations of the modified chitosan aqueous solution, ceramide aqueous solution, squalane aqueous solution, and hyaluronic acid aqueous solution in step (3) are all 15 - 30 mg / mL.

[0019] Further, the high - pressure homogenization in step (3) is carried out in a high - pressure homogenizer at 600 Bar and 75 °C for 3 - 5 min.

[0020] Compared with the prior art, the beneficial effects achieved by the present invention are as follows:

[0021] The antioxidant and moisturizing cosmetic prepared by the present invention achieves a high - moisturizing effect on the basis of realizing antioxidant function.

[0022] First, a novel antioxidant is prepared by grafting cinnamyl nitrile onto vitamin C through the catalytic conjugate addition reaction of hydroxyl and double bonds; after cinnamyl nitrile is grafted onto vitamin C, due to the conjugated structure and π - electrons of the benzene ring and cyano group, the novel antioxidant can absorb ultraviolet light, thus playing a certain sun - protection role, reducing the direct damage of ultraviolet rays to the skin, and at the same time effectively protecting the skin from the invasion of free radicals and reducing the occurrence of photosensitization reactions of other components in the cosmetic; vitamin C is easily oxidized in the cosmetic, and the introduction of cinnamyl nitrile can improve the stability of the whole molecule, reduce the oxidation loss of vitamin C during storage and use, and this improvement in stability helps to maintain the antioxidant activity of vitamin C, making its shelf - life in the cosmetic longer and further enhancing the antioxidant effect of the cosmetic.

[0023] Second, modified chitosan is prepared by grafting long - chain fatty acids onto chitosan through the acylation reaction of long - chain fatty acyl chloride and chitosan, and then a high - moisturizing factor is prepared by loading active ingredients such as modified chitosan and squalane with liposomes; during use, when the liposomes contact the skin, the liposomes will act on the cell membrane on the skin surface and the active ingredients will be released. After the active ingredients such as squalane are released, they can penetrate into the skin epidermis, repair the water - absorption ability and barrier structure of the stratum corneum, thereby maintaining the water content of the skin stratum corneum and playing a moisturizing effect; the hydrophobic end of the modified chitosan will combine with the lipid substances in the skin, improving the water - locking ability of the skin and reducing the loss of water in the skin. At the same time, the hydrophilic end will be exposed outside, binding and retaining a large amount of water, enhancing the water - absorption and water - retention ability of the skin, forming the effect of internal water - locking and external water - absorption, and further improving the moisturizing effect of the cosmetic. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] In order to more clearly illustrate the method provided by the present invention, the following examples are used to describe in detail the test methods of various indicators of the antioxidant moisturizing cosmetics prepared in the following examples are as follows:

[0026] Antioxidant performance: The same mass of the antioxidant moisturizing cosmetics prepared in the example and the comparative example were respectively prepared into a 1 mg / mL solution using anhydrous ethanol, and then 100 μL of each solution was respectively added dropwise to 3 mL of DPPH solution, and after being fully mixed, the mixture was allowed to stand at room temperature for 30 minutes, and the absorbance A at a wavelength of 519 nm was detected to test its ability to scavenge free radicals. Calculation of free radical scavenging rate (inhibition%): (%) = [(A blank - A sample) / A blank] × 100.

[0027] Moisturizing performance: The antioxidant moisturizing cosmetics prepared in the embodiment and the comparative example of the same mass were selected for volunteers, and the moisturizing performance was determined by using a skin moisture tester to measure the water ionization degree in the skin epidermis using a sensor, and the measurement results were expressed as numerical values, and the moisture content was calculated. The specific method is: 50 people with dry skin or believed to have dry skin were selected and randomly divided into 5 groups, with 10 people in each group. Each group of people was tested for moisturizing performance. Before starting use, the skin moisture content of each subject was measured under constant temperature and constant humidity (24°C and 40% humidity) using a skin moisture tester, and used as a reference value. The skin moisture content was measured 2h and 8h after use, and 5 groups were tested with the same formula, and the average value was taken.

[0028] Example 1

[0029] A method for preparing an antioxidant moisturizing cosmetic comprises the following steps:

[0030] (1) Cinnamonitrile and vitamin C were mixed at a molar ratio of 1:1.5, 50 wt% ethanol aqueous solution was added in an amount of 3 times the mass of cinnamonitrile, and stirred at 200 r / min for 5 min, 0.04 times the mass of cinnamonitrile ruthenium carbon catalyst was added, 0.08 times the mass of cinnamonitrile potassium carbonate was added, and stirred at 100 r / min for 5 min. The flow rate was 10 Nm 3Nitrogen at [X] Nm³ / h was heated to 75 °C, reacted for 2.0 h, cooled to room temperature, filtered to obtain the filtrate, and the solvent was removed by distillation to obtain the novel antioxidant;

[0031] (2) Chitosan was placed in pyridine with a mass 3 times that of chitosan for 24 h, dried in a vacuum drying oven at 50 °C and 50 kPa for 2 h, added to a mixed solution of pyridine and chloroform (volume ratio 1:1) with a volume 20 times that of chitosan, added myristoyl chloride with a molar amount 1.0 times that of chitosan, stirred at 400 r / min for 10 min, heated to 60 °C, reacted for 8 h, cooled to room temperature to obtain a mixed solution, added methanol with a mass 10 times that of the mixed solution, filtered to obtain the crude product of modified chitosan, washed 3 times with methanol, and dried in a vacuum drying oven at 45 °C and 50 kPa for 1 h to obtain modified chitosan;

[0032] (3) Egg yolk lecithin, cholesterol, glycerol, and butanediol were mixed in a mass ratio of 1:0.5:4:5 as phase A, and an aqueous solution of modified chitosan, an aqueous solution of ceramide, an aqueous solution of squalane, and an aqueous solution of hyaluronic acid with a concentration of 15 mg / mL were mixed in a mass ratio of 1:1.0:1.0:1.0 as phase B. Phase A and phase B were respectively heated to 75 °C, stirred at 400 r / min until completely dissolved, the temperature of phase A was kept unchanged, the rotation speed was increased to 10000 r / min, phase B was slowly added to phase A, and placed in a high-pressure homogenizer, homogenized at 600 Bar and 75 °C for 3 min to obtain a high moisture retention factor;

[0033] (4) By weight, 1.0 part of the novel antioxidant, 10 parts of the high moisture retention factor, 1.5 parts of alginate, 3 parts of hydrolyzed collagen, 0.5 part of sodium citrate, 0.01 part of EDTA-2Na, and 60 parts of purified water were mixed to prepare the antioxidant and moisturizing cosmetic.

[0034] Example 2

[0035] A preparation method of an antioxidant and moisturizing cosmetic, comprising the following preparation steps:

[0036] (1) Cinnamon nitrile and vitamin C were mixed at a molar ratio of 1:1.7, added to a 50 wt% aqueous ethanol solution with a mass 4 times that of cinnamon nitrile, stirred at 250 r / min for 7 min, added ruthenium-carbon catalyst with a molar amount 0.05 times that of cinnamon nitrile, added potassium carbonate with a molar amount 0.10 times that of cinnamon nitrile, stirred at 130 r / min for 6 min, and nitrogen with a flow rate of 10 Nm 3 / h was heated to 77 °C, reacted for 2.3 h, cooled to room temperature, filtered to obtain the filtrate, and the solvent was removed by distillation to obtain the novel antioxidant;

[0037] Note: There seems to be a value missing in the "10 Nm " in step (1) of Example 2. It should be something like "10 Nm³ / h" for example to make more sense in the context of a gas flow rate. The translation is done based on the provided text as accurately as possible with the assumption of a complete value for the gas flow rate.(2) Chitosan was placed in pyridine with a mass 4 times that of chitosan for 24 h, dried in a vacuum drying oven at 50 °C and 55 kPa for 2.5 h. A mixed solution of pyridine and chloroform (volume ratio 1:1) with a mass 23 times that of chitosan was added, and myristoyl chloride with a molar amount 1.1 times that of chitosan was added. It was stirred at 500 r / min for 13 min, heated to 65 °C, reacted for 8 h, cooled to room temperature to obtain a mixed solution. Methanol with a mass 13 times that of the mixed solution was added, and the crude product of modified chitosan was obtained by filtration. It was washed 4 times with methanol and dried in a vacuum drying oven at 45 °C and 55 kPa for 1.5 h to obtain modified chitosan;

[0038] (3) Egg yolk lecithin, cholesterol, glycerol, and butanediol were mixed in a mass ratio of 1:0.6:5:7 as phase A. An aqueous solution of modified chitosan, an aqueous solution of ceramide, an aqueous solution of squalane, and an aqueous solution of hyaluronic acid with a concentration of 25 mg / mL were mixed in a mass ratio of 1:1.1:1.1:1.1 as phase B. Phase A and phase B were respectively heated to 77 °C and stirred at 500 r / min until completely dissolved. Keeping the temperature of phase A unchanged, the rotation speed was increased to 11000 r / min, and phase B was slowly added to phase A. It was placed in a high-pressure homogenizer and homogenized at 600 Bar and 75 °C for 4 min to obtain a high-moisture retention factor;

[0039] (4) By weight, 1.3 parts of a novel antioxidant, 13 parts of the high-moisture retention factor, 2.5 parts of alginate, 4 parts of hydrolyzed collagen, 1.0 part of sodium citrate, 0.5 part of EDTA-2Na, and 65 parts of purified water were mixed to prepare an antioxidant and moisturizing cosmetic.

[0040] Example 3

[0041] A preparation method of an antioxidant and moisturizing cosmetic, comprising the following preparation steps:

[0042] (1) Cinnamon nitrile and vitamin C were mixed at a molar ratio of 1:1.8. An aqueous solution of ethanol with a mass 5 times that of cinnamon nitrile and a concentration of 50 wt% was added, and it was stirred at 300 r / min for 8 min. A ruthenium-carbon catalyst with a molar amount 0.06 times that of cinnamon nitrile was added, and potassium carbonate with a molar amount 0.12 times that of cinnamon nitrile was added. It was stirred at 150 r / min for 8 min, nitrogen with a flow rate of 10 Nm 3 / h was introduced, heated to 80 °C, reacted for 2.5 h, cooled to room temperature, filtered to obtain the filtrate, and the solvent was distilled off to obtain a novel antioxidant;

[0043] (2) Chitosan was placed in pyridine with a mass 4 times that of chitosan for 24 h, dried in a vacuum drying oven at 50 °C and 60 kPa for 3 h, added to a mixed solution of pyridine and chloroform (volume ratio 1:1) with a volume 25 times that of chitosan, added lauroyl chloride with a molar amount 1.2 times that of chitosan, stirred at 600 r / min for 15 min, heated to 70 °C, reacted for 8 h, cooled to room temperature to obtain a mixed solution, added methanol with a mass 15 times that of the mixed solution, filtered to obtain a crude product of modified chitosan, washed 5 times with methanol, and dried in a vacuum drying oven at 45 °C and 60 kPa for 2 h to obtain modified chitosan;

[0044] (3) Egg yolk lecithin, cholesterol, glycerol, and butanediol were mixed in a mass ratio of 1:0.6:6:8 as phase A, and an aqueous solution of modified chitosan, an aqueous solution of ceramide, an aqueous solution of squalane, and an aqueous solution of hyaluronic acid with a concentration of 30 mg / mL were mixed in a mass ratio of 1:1.2:1.1:1.2 as phase B. Phase A and phase B were heated to 80 °C respectively, stirred at 600 r / min until completely dissolved, keeping the temperature of phase A unchanged, increasing the rotation speed to 12,000 r / min, slowly adding phase B to phase A, and placing it in a high-pressure homogenizer, homogenizing at 600 Bar and 75 °C for 5 min to obtain a high moisture retention factor;

[0045] (4) By weight, 1.5 parts of a novel antioxidant, 15 parts of the high moisture retention factor, 3.5 parts of seaweed gum, 5 parts of hydrolyzed collagen, 1.5 parts of sodium citrate, 1 part of EDTA-2Na, and 75 parts of purified water were mixed to prepare an antioxidant and moisturizing cosmetic.

[0046] Comparative Example 1

[0047] The difference between Comparative Example 1 and Example 2 is that step (1) was not carried out, and step (4) was changed to: By weight, 1.3 parts of vitamin C, 13 parts of the high moisture retention factor, 2.5 parts of seaweed gum, 4 parts of hydrolyzed collagen, 1.0 part of sodium citrate, 0.5 part of EDTA-2Na, and 65 parts of purified water were mixed to prepare an antioxidant and moisturizing cosmetic; the remaining steps were the same as those in Example 2.

[0048] Comparative Example 2

[0049] The difference between Comparative Example 2 and Example 2 is that step (1) was not carried out, and step (4) was changed to: By weight, 1.3 parts of cinnamaldehyde nitrile, 13 parts of the high moisture retention factor, 2.5 parts of seaweed gum, 4 parts of hydrolyzed collagen, 1.0 part of sodium citrate, 0.5 part of EDTA-2Na, and 65 parts of purified water were mixed to prepare an antioxidant and moisturizing cosmetic; the remaining steps were the same as those in Example 2.

[0050] Comparative Example 3

[0051] The difference between Comparative Example 3 and Example 2 is that step (2) is absent, and step (3) is changed to: Mix egg yolk lecithin, cholesterol, glycerol, and butanediol in a mass ratio of 1:0.6:5:7 as Phase A, and mix chitosan aqueous solution, ceramide aqueous solution, squalane aqueous solution, and hyaluronic acid aqueous solution with a concentration of 25 mg / mL each in a mass ratio of 1:1.1:1.1:1.1 as Phase B. Heat Phase A and Phase B to 77°C respectively, stir at 500 r / min until completely dissolved, keep the temperature of Phase A unchanged, increase the rotation speed to 11,000 r / min, slowly add Phase B to Phase A, place it in a high-pressure homogenizer, and homogenize at 600 Bar and 75°C for 4 min to obtain a high-moisture factor; the remaining steps are the same as those in Example 2.

[0052] Comparative Example 4

[0053] The difference between Comparative Example 4 and Example 2 lies in the difference in step (3). Step (3) is changed to: Mix chitosan-modified aqueous solution, ceramide aqueous solution, squalane aqueous solution, and hyaluronic acid aqueous solution with a concentration of 25 mg / mL each in a mass ratio of 1:1.1:1.1:1.1, heat to 77°C, stir at 500 r / min until completely dissolved, place it in a high-pressure homogenizer, and homogenize at 600 Bar and 75°C for 4 min to obtain a high-moisture factor; the remaining steps are the same as those in Example 2.

[0054] Effect Example

[0055] The performance analysis results of the antioxidant and moisturizing cosmetics using Examples 1 to 3 and Comparative Examples 1 to 4 of the present invention are given in Table 1 below.

[0056] Table 1

[0057]

[0058] From the comparison of the experimental data of Example 2 with Comparative Examples 1 and 2, it can be found that the present invention uses the catalytic conjugate addition reaction of hydroxyl and double bonds to graft cinnamitrile onto vitamin C to prepare a novel antioxidant; after cinnamitrile is grafted onto vitamin C, due to the conjugated structure and π electrons of the benzene ring and cyano group, the novel antioxidant can absorb ultraviolet light, thus playing a certain sunscreen role, reducing the direct damage of ultraviolet rays to the skin, and at the same time being able to effectively protect the skin from the invasion of free radicals, reducing the occurrence of photosensitization reactions of other components in cosmetics; vitamin C is easily oxidized in cosmetics, and the introduction of cinnamitrile can improve the stability of the whole molecule, reduce the oxidative loss of vitamin C during storage and use, and this improvement in stability helps to maintain the antioxidant activity of vitamin C, making its shelf life in cosmetics longer and further enhancing the antioxidant effect of cosmetics; from the comparison of the experimental data of Example 2 with Comparative Examples 3 and 4, it can be found that the present invention uses the acylation reaction of long-chain fatty acyl chloride and chitosan to graft long-chain fatty acids onto chitosan to prepare modified chitosan, and then uses liposomes to load active ingredients such as modified chitosan and squalane to prepare a high moisturizing factor; when in use, when the liposomes contact the skin, the liposomes will act on the cell membrane on the skin surface, and the active ingredients will be released. After the active ingredients such as squalane are released, they can penetrate into the epidermis of the skin to repair the water absorption capacity and barrier structure of the stratum corneum, thereby maintaining the water content of the stratum corneum of the skin and playing a moisturizing effect; the hydrophobic end of the modified chitosan will combine with the lipid substances in the skin to improve the water locking ability of the skin, reduce the loss of water in the skin, and at the same time the hydrophilic end will be exposed outside, binding and retaining a large amount of water, enhancing the water absorption and water retention ability of the skin, forming the effect of internal water locking and external water absorption, and further improving the moisturizing effect of cosmetics.

[0059] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present invention, the present invention can be implemented in other specific forms. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, it is intended to include all changes falling within the meaning and scope of the equivalent elements of the claims in the present invention. Any reference signs in the claims should not be construed as limiting the claimed claim.

Claims

1. An antioxidant moisturizing cosmetic, characterized in that: The antioxidant moisturizing cosmetic is composed of a novel antioxidant, a high moisturizing factor, alginate, hydrolyzed collagen, sodium citrate, EDTA-2Na and purified water.

2. An antioxidant moisturizing cosmetic according to claim 1, characterized in that: The novel antioxidant is prepared by grafting cinnamonitrile onto vitamin C through a catalytic conjugate addition reaction of a hydroxyl group and a double bond.

3. The antioxidant moisturizing cosmetic according to claim 1, characterized in that: The high moisturizing factor is prepared by utilizing the acylation reaction of long-chain fatty acid chloride and chitosan to graft long-chain fatty acid onto chitosan to prepare modified chitosan, and then utilizing liposome to load the modified chitosan and active ingredients.

4. The antioxidant moisturizing cosmetic according to claim 4, characterized in that: The active ingredients include one or more of squalane, ceramide and hyaluronic acid.

5. A method for preparing an antioxidant moisturizing cosmetic, characterized in that: The method comprises the following preparation steps: (1) Cinnamonitrile and vitamin C are mixed at a molar ratio of 1:1.5-1.8, 3-5 times the mass of cinnamonitrile is added with a 50 wt% ethanol aqueous solution, stirred at 200-300 r / min for 5-8 min, 0.04-0.06 times the mass of cinnamonitrile is added with a catalyst, 0.08-0.12 times the mass of cinnamonitrile is added with potassium carbonate, stirred at 100-150 r / min for 5-8 min, nitrogen is introduced, the temperature is raised to 75-80° C., the reaction is carried out for 2.0-2.5 h, the mixture is cooled to room temperature, the filtrate is filtered, and the solvent is removed by distillation to obtain a novel antioxidant; (2) placing chitosan in pyridine of 3 to 4 times its mass for 24 hours, drying in a vacuum drying oven at 50°C and 50 to 60 kPa for 2 to 3 hours, adding a mixed solution of pyridine and chloroform of 20 to 25 times its mass, adding tetradecanoyl chloride of 1.0 to 1.2 times its mass, stirring at 400 to 600 r / min for 10 to 15 minutes, heating to 60 to 70°C, reacting for 8 hours, cooling to room temperature to obtain a mixed solution, adding methanol of 10 to 15 times its mass, filtering to obtain a modified chitosan primary product, washing with methanol for 3 to 5 times, and drying in a vacuum drying oven at 45°C and 50 to 60 kPa for 1 to 2 hours to obtain the modified chitosan; (3) Egg yolk lecithin, cholesterol, glycerol, and butylene glycol are mixed in a mass ratio of 1:0.5-0.6:4-6:5-8 as phase A, and modified chitosan aqueous solution, ceramide aqueous solution, squalane aqueous solution, and hyaluronic acid aqueous solution are mixed in a mass ratio of 1:1.0-1.2:1.0-1.1:1.0-1.2 as phase B. Phase A and phase B are heated to 75-80°C, respectively, and stirred at 400-600 r / min until completely dissolved, while keeping the temperature of phase A unchanged, increasing the rotation speed to 10,000-12,000 r / min, and slowly adding phase B to phase A, and homogenizing under high pressure to obtain a high moisturizing factor; (4) By weight, 1.0-1.5 parts of a novel antioxidant, 10-15 parts of a high moisturizing factor, 1.5-3.5 parts of alginate, 3-5 parts of hydrolyzed collagen, 0.5-1.5 parts of sodium citrate, 0.01-1 part of EDTA-2Na and 60-75 parts of purified water are mixed to prepare an antioxidant moisturizing cosmetic.

6. The method for preparing an antioxidant moisturizing cosmetic according to claim 4, characterized in that: The catalyst in step (1) is a ruthenium-on-carbon catalyst.

7. The method for preparing an antioxidant moisturizing cosmetic according to claim 4, characterized in that: The flow rate of nitrogen in step (1) is 10 Nm 3 / h.

8. The method for preparing an antioxidant moisturizing cosmetic according to claim 4, characterized in that: The mixed solution of pyridine and chloroform in step (2) is prepared by mixing pyridine and chloroform in a volume ratio of 1:

1.

9. The method for preparing an antioxidant moisturizing cosmetic according to claim 4, characterized in that: In the step (3), the concentrations of the modified chitosan aqueous solution, the ceramide aqueous solution, the squalane aqueous solution and the hyaluronic acid aqueous solution are all 15-30 mg / mL.

10. The method for preparing an antioxidant moisturizing cosmetic according to claim 4, characterized in that: The high pressure homogenization in step (3) is to place the mixture in a high pressure homogenizer and homogenize at 600 Bar and 75° C. for 3 to 5 minutes.

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