Solid water-soluble hand sanitizer and preparation method thereof

Abstract

The invention belongs to the technical field of hand sanitizer preparation, and particularly relates to a solid-state water-soluble hand sanitizer and a preparation method thereof.The solid-state water-soluble hand sanitizer is prepared from basic raw materials and functional component raw materials according to the specific matching proportion of a formula, the hand sanitizer has the effects of inhibiting bacteria, preserving moisture and resisting allergy, and therefore human skin is promoted to recover healthy vitality; wherein the basic raw material is prepared from the following components in parts by weight: 10%-50% of a moisturizing forming agent, 5%-20% of a foaming agent, 0.5%-2% of a preservative and 0.5%-1% of an aromatic; the functional component raw materials are prepared from the following components in parts by weight: 0.1%-1% of phosphorylcholine polymer, 1%-10% of betaine, 0.2%-2% of salicylic acid, 0.1%-1% of a purslane extract, 0.1%-1% of a scutellaria baicalensis root extract, 0.1%-1% of a centella asiatica extract, 0.1%-1% of a white willow bark extract, 0.1%-1% of sorbic acid and 0.1%-1% of citric acid. The antibacterial effect is higher and the quality guarantee period is longer; more efficient moisturizing, mildness and cleanness are realized.

Description

Technical Field

[0001] The invention relates to the technical field of hand sanitizer preparation, in particular to a solid water-soluble hand sanitizer and a preparation method thereof. Background Art

[0002] Due to the fast pace of modern life and work and environmental pollution, humans are inevitably exposed to various harmful germs, such as door handles in public areas, elevator handrails, buttons, etc. Harmful germs can cause many skin problems, such as skin infections, pathogenic bacteria infections, itching, redness, etc., and even eczema, dermatitis and other diseases in severe cases. This has caused great trouble and annoyance to people today. In recent years, with the advancement of cosmetic raw material technology and the rapid development of medicine and other fields, by adding a series of new moisturizing, antibacterial and mild raw materials, a hand sanitizer product with certain moisturizing, antibacterial and anti-sensitive properties is prepared, which can better inhibit and solve various hand skin problems such as dryness, bacterial growth, itching, redness, etc.

[0003] On the other hand, most of the current hand sanitizers are in liquid form and are packaged in bottles and cans. They are prone to leakage when carried, and are inconvenient to carry when traveling or on business trips, and cannot be carried on airplanes. In addition, the cost of packaging and transportation is relatively high, which does not bring convenience to consumers. Consumers have a stronger demand for portable skin care products when traveling, and they hope to carry concentrated skin care products so that they can reduce the amount of skin care products when traveling.

[0004] Moreover, compared with ordinary skin care products, concentrated hand sanitizers have the advantages of high active ingredient content, low production cost, low carbon emissions, saving packaging materials and reducing transportation costs. They not only save energy and reduce the impact on the environment, but also save costs, achieving multiple goals at one stroke. It is more in line with the requirements of sustainable economic and social development and is an inevitable trend in the future development of antibacterial and moisturizing hand care products.

[0005] Phosphorylcholine polymers are a class of polymers with phosphorylcholine groups as structural features. Phosphorylcholine is the main component of cell membrane phospholipids and has excellent biocompatibility, anticoagulant and anti-protein deposition properties. In the field of cosmetics, phosphorylcholine polymers have attracted attention due to their unique moisturizing properties and mildness to the skin. Phosphorylcholine polymers have excellent water retention properties and can lock in skin moisture and keep the skin moisturized. This property makes it an important moisturizing ingredient in cosmetics.

[0006] Therefore, there is a need to add effective components such as antibacterial, moisturizing, and anti-allergic to hand sanitizers, so as to promote the recovery of healthy vitality of human skin; there is also a need to prepare solid concentrated products that are easy to carry and use.

[0007] Therefore, it is very necessary to develop a series of solid concentrated hand sanitizers containing bacteriostatic, moisturizing, anti-allergic and other ingredients, which also have great market value and application value. Summary of the Invention

[0008] The purpose of this part is to outline some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Simplifications or omissions may be made in this part, as well as in the abstract and title of the specification of this application, to avoid obscuring the purpose of this part, the abstract and the title, and such simplifications or omissions shall not be used to limit the scope of the present invention.

[0009] In view of the problems existing in the prior art, the present invention is proposed.

[0010] Therefore, the object of the present invention is to provide a solid water-soluble hand sanitizer, which can achieve a higher antibacterial effect with a longer shelf life through the combination of eight special components; it has more efficient moisturizing and gentle cleansing.

[0011] To solve the above technical problems, according to one aspect of the present invention, the following technical solutions are provided:

[0012] A solid water-soluble hand sanitizer, which comprises basic raw materials and functional ingredient raw materials according to the specific mixing ratio of the formula. Among them,

[0013] The basic raw materials are made up of the following components by weight: 10% - 50% of a moisturizing and shaping agent, 5% - 20% of a foaming agent, 0.5% - 2% of a preservative, and 0.5% - 1% of an aromatic agent;

[0014] The functional ingredient raw materials are made up of the following components by weight: 0.1% - 1% of a phosphorylcholine polymer, 1% - 10% of betaine, 0.2% - 2% of salicylic acid, 0.1% - 1% of purslane extract, 0.1% - 1% of Scutellaria baicalensis root extract, 0.1% - 1% of centella asiatica extract, 0.1% - 1% of white willow bark extract, 0.1% - 1% of sorbic acid, and 0.1% - 1% of citric acid.

[0015] As a further improvement of the invention, the phosphorylcholine polymer is one of polyquaternium-51 and polyquaternium-61.

[0016] As a further improvement of the invention, the moisturizing and shaping agent in the basic raw materials comprises sorbitol and urea raw materials according to the specific mixing ratio of the formula, wherein sorbitol accounts for 10% - 50% and urea accounts for 10% - 50%.

[0017] As a further improvement of the invention, the preservative in the basic raw materials is sodium benzoate, accounting for 0.5% - 2%, and the aromatic agent in the basic raw materials is essence, accounting for 0.5% - 1%.

[0018] As a further improvement of the invention, the foaming agent in the basic raw material is one or a mixture of sodium methyl cocoyl taurate, sodium lauroyl glutamate, and sodium lauryl sulfate, wherein sodium methyl cocoyl taurate is 5% to 20%, sodium lauroyl glutamate is 5% to 20%, and sodium lauryl sulfate is 5% to 20%.

[0019] As a further improvement of the invention, the extraction steps of the purslane extract, scutellaria root extract, Centella asiatica extract and willow bark extract are as follows: after cleaning, the purslane, scutellaria root, Centella asiatica and willow bark are respectively put into a grinder for grinding, and then screened and purified through an 80-120 mesh sieve to finally obtain the finished purslane extract, scutellaria root extract, Centella asiatica extract and willow bark extract.

[0020] A method for preparing a solid water-soluble hand sanitizer comprises the following steps:

[0021] A. Weigh each raw material according to the proportion of each raw material by mass, place sorbitol, urea, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium lauryl sulfate, phosphorylcholine polymer, purslane extract, scutellaria root extract, Centella asiatica extract, and white willow bark extract in a 55° C. oven, dry for 24 hours, place in a stirring pot, and stir and mix;

[0022] B. Place the dried raw materials in step A and the undried sodium benzoate, flavor, betaine, salicylic acid, sorbic acid, and citric acid in a stirring pot and stir and disperse them fully, and take samples for pH value detection, the pH value is 5.5-6.5;

[0023] C. Transfer the mixed raw materials qualified by pH test in step B to a tablet press for tableting, and compress the powder mixture at a unit area pressure of 35-50 kg / cm2 to obtain a preformed block;

[0024] D. Send the preformed blocks to a dehumidification room, dehumidify and package them under the conditions of temperature 20-25°C and humidity 20%-40%RH to obtain solid water-soluble hand sanitizer.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows: Through the combination of eight special components, betaine has the effects of moisturizing and anti-allergy; salicylic acid has the effects of bacteriostasis and soothing; purslane extract has the effects of soothing, antibacterial and anti-inflammatory; the film-forming property of phosphorylcholine polymer on the skin reduces irritation and enhances the moisturizing and repair effects; skullcap root extract has the effects of soothing, antibacterial and anti-inflammatory; centella asiatica extract has the effects of anti-allergy, anti-inflammatory, acne removal and whitening; white willow bark extract has the effects of anti-inflammatory, anti-wrinkle and acne removal; sorbic acid has the effects of antibacterial and anti-corrosion; citric acid has the effects of antibacterial and pH adjustment. The combination of the eight special components can achieve a higher antibacterial effect with a longer shelf life; and has more efficient moisturizing and mild cleansing functions. Detailed implementation manners

[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts belong to the scope of protection of the present invention.

[0027] Phosphorylcholine polymers are represented by polyquaternium-51 and polyquaternium-61. Polyquaternium-51 has super strong moisturizing property, and its moisturizing performance is twice that of hyaluronic acid. It can alleviate the irritation of surfactants. Therefore, it is widely used as a raw material for cosmetics moisturizers and the medical beauty field. It can form a breathable biofilm on the skin surface, simulate the stratum corneum to give the skin an extra layer of protection, effectively inhibit the irritation of surfactants to the skin, improve skin roughness, smooth and delicate the skin, and enhance the absorption of active ingredients by the skin. Polyquaternium-61 is commonly used as a film-forming agent, skin conditioner and moisturizer in cosmetics. Polyquaternium-61 helps to form a protective film to protect the skin from the harm of the external environment, has moisturizing performance, and helps to maintain the moisture balance of the skin.

[0028] Purslane extract has significant anti-inflammatory and antibacterial effects, can soothe the skin and reduce skin problems caused by inflammation. It contains rich vitamin E and vitamin C, and these components can slow down the aging speed of the skin, promote the synthesis of collagen, make the skin stronger. The carbohydrates in the extract can help the skin establish a healthy barrier, play a role in soothing the skin, and inhibit skin itching problems caused by dryness. It can effectively improve skin sensitivity problems caused by long-term use of cosmetics, resist the stimulation of the external environment to the skin, and is a very effective anti-allergy ingredient.

[0029] Baicalin and baicalein are the main active ingredients of the root extract of Scutellaria baicalensis. The Scutellaria baicalensis extract has an inhibitory effect on a variety of dermatophytes and has anti-inflammatory and anti-allergic effects. The Scutellaria baicalensis extract can neutralize the released histamine, has an anti-allergic effect, can enhance the skin barrier function, reduce skin moisture loss, and enhance the skin's self-protection ability.

[0030] The flavonoids in the Centella asiatica extract have anti-inflammatory effects, can reduce the inflammatory response, have the effect of inhibiting the excessive proliferation of keratinocytes, and thus reduce the occurrence of abnormal keratinization. It contains rich polyphenolic compounds, which help to improve the skin barrier function and enhance the skin's water retention ability.

[0031] Salicin is the main active ingredient of white willow bark, has anti-wrinkle effects, can increase skin elasticity, and achieve the effect of anti-aging. Due to its aspirin-like properties, salicin has certain anti-inflammatory effects. It can prevent pore blockage for acne, is most effective for blackheads, reduces the abnormal shedding of the hair follicle wall, and prevents the occurrence of acne. Using salicin as an anti-irritant compound in cosmetics and topical skin preparations can improve atopic dermatitis and increase the irritation threshold of sensitive skin.

[0032] Example 1

[0033] In this example, the phosphorylcholine polymer is preferably polyquaternium-51.

[0034] A solid water-soluble hand sanitizer, with the basic raw materials and active ingredient raw materials specifically formulated according to the formula.

[0035] A solid water-soluble hand sanitizer, the basic components are formulated according to the following total weight percentages: sorbitol 10%, urea 10%, sodium methyl cocoyl taurate 5%, sodium lauroyl glutamate 5%, sodium lauryl sulfate 5%, sodium benzoate 0.5%, essence 0.5%

[0036] The active ingredients are formulated according to the following total weight percentages: polyquaternium-51 0.1%, betaine 1%, salicylic acid 0.2%, purslane extract 0.1%, Scutellaria baicalensis root extract 0.1%, Centella asiatica extract 0.1%, white willow bark extract 0.1%, sorbic acid 0.1%, citric acid 0.1%.

[0037] Its preparation method includes the following steps:

[0038] A. Weigh each raw material according to the proportion of the mass parts of each raw material. Place the sorbitol, urea, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium lauryl sulfate, phosphorylcholine polymer, purslane extract, Scutellaria baicalensis root extract, Centella asiatica extract, and white willow bark extract in an oven at 55°C, dry for 24 hours, and then place them in a stirring pot for stirring and mixing;

[0039] B. Place the dried raw materials in step A and the undried sodium benzoate, flavor, betaine, salicylic acid, sorbic acid, and citric acid in a stirring pot and stir and disperse them fully, and take samples for pH value detection, the pH value is 5.5-6.5;

[0040] C. Transfer the mixed raw materials qualified by pH test in step B to a tablet press for tableting, and compress the powder mixture at a unit area pressure of 35-50 kg / cm2 to obtain a preformed block;

[0041] D. Send the preformed blocks to a dehumidification room, dehumidify and package them under the conditions of temperature 20-25°C and humidity 20%-40%RH to obtain solid water-soluble hand sanitizer.

[0042] Example 2

[0043] In this embodiment, the phosphorylcholine polymer is preferably polyquaternium-61.

[0044] A solid water-soluble hand sanitizer, wherein the basic raw materials and the functional component raw materials are specifically matched according to a formula.

[0045] A solid water-soluble hand sanitizer, the basic ingredients of which are prepared according to the following total weight percentages: 50% sorbitol, 50% urea, 20% sodium methyl cocoyl taurate, 20% sodium lauroyl glutamate, 20% sodium lauryl sulfate, 2% sodium benzoate, and 1% flavor

[0046] The effective ingredients are formulated according to the following total weight percentage: polyquaternium-61 1%, betaine 10%, salicylic acid 2%, purslane extract 1%, scutellaria root extract 1%, Centella asiatica extract 1%, white willow bark extract 1%, sorbic acid 1%, and citric acid 1%.

[0047] The preparation method thereof comprises the following steps:

[0048] A. Weigh each raw material according to the proportion of each raw material by mass, place sorbitol, urea, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium lauryl sulfate, phosphorylcholine polymer, purslane extract, scutellaria root extract, Centella asiatica extract, and white willow bark extract in a 55° C. oven, dry for 24 hours, place in a stirring pot, and stir and mix;

[0049] B. Place the dried raw materials in step A and the undried sodium benzoate, flavor, betaine, salicylic acid, sorbic acid, and citric acid in a stirring pot and stir and disperse them fully, and take samples for pH value detection, the pH value is 5.5-6.5;

[0050] C. Transfer the fully mixed raw materials that have passed the pH test in step B to a tablet press for tablet pressing. Press the powder mixture under a unit area pressure of 35 - 50 kg / cm2 to obtain a preformed block.

[0051] D. Send the preformed block into a dehumidifying room, and dehumidify and package it under the conditions of a temperature of 20 - 25 °C and a humidity of 20% - 40% RH to obtain a solid water-soluble hand sanitizer.

[0052] Example 3

[0053] In this example, the phosphorylcholine polymer is preferably polyquaternium-51.

[0054] A solid water-soluble hand sanitizer, with the basic raw materials and the functional ingredient raw materials specifically formulated according to the recipe.

[0055] A solid water-soluble hand sanitizer, with the basic ingredients formulated according to the following total weight percentages: sorbitol 28.5%, urea 45%, sodium methyl cocoyl taurate 18%, sodium lauroyl glutamate 18%, sodium lauryl sulfate 18%, sodium benzoate 2%, essence 1%

[0056] The functional ingredients are formulated according to the following total weight percentages: polyquaternium-51 1%, betaine 1%, salicylic acid 1.5%, purslane extract 0.5%, skullcap root extract 0.5%, centella asiatica extract 0.5%, white willow bark extract 0.5%, sorbic acid 0.5%, citric acid 0.5%.

[0057] Its preparation method includes the following steps:

[0058] A. Weigh each raw material according to the proportion of the mass parts of each raw material. Place sorbitol, urea, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium lauryl sulfate, phosphorylcholine polymer, purslane extract, skullcap root extract, centella asiatica extract, and white willow bark extract in the raw materials in an oven at 55 °C. After drying for 24 hours, place them in a stirring pot and stir and mix.

[0059] B. Place the dried raw materials in step A and the undried sodium benzoate, essence, betaine, salicylic acid, sorbic acid, and citric acid together in a stirring pot and stir and disperse them fully. Take a sample for pH value detection, and the pH value is 5.5 - 6.5.

[0060] C. Transfer the fully mixed raw materials that have passed the pH test in step B to a tablet press for tablet pressing. Press the powder mixture under a unit area pressure of 35 - 50 kg / cm2 to obtain a preformed block.

[0061] D. Feed the preformed block into the dehumidifying room, dehumidify and package it under the conditions of temperature 20 - 25°C and humidity 20% - 40% RH to obtain the solid water-soluble hand sanitizer.

[0062] Test data of the embodiment of the present invention (solid water-soluble hand sanitizer)

[0063]

[0064] Test the effect of the embodiment of the present invention (solid water-soluble hand sanitizer). 60 cases were clinically observed as the experimental group, with the age range of 18 - 60 years old. The people in the experimental group used the product of the present invention each time they washed their hands. Experimental results: This hand sanitizer can quickly and effectively remove pollutants such as dirt, grease and bacteria on the hands, keeping the hands clean and hygienic. After 15 - 30 days of use, through human skin tests, most of the subjects did not show any discomfort reactions such as redness, itching or stinging after use, which indicates that this hand sanitizer has low irritation to the skin and has a certain moisturizing effect, capable of keeping the hand skin moist and comfortable. After 40 days of use, the moisture content of the hand skin increased, the skin became soft, smooth and not easily dried. This is due to the moisturizing components in the hand sanitizer, which can moisten the skin and prevent problems such as cracks or itching on the hand skin caused by dryness. Through clinical observation tests, key indicators such as the cleaning effect, bactericidal performance, skin irritation and moisturizing effect of the solid water-soluble hand sanitizer can be evaluated. If the test results show that the solid water-soluble hand sanitizer has a significant cleaning effect, good bactericidal performance, low irritation and excellent moisturizing effect, then it can be considered that this product is safe, effective and reliable in practical applications. This will provide strong support for the further promotion and application of the solid water-soluble hand sanitizer.

[0065] Although the present invention has been described above with reference to the embodiments, various improvements can be made to it and components therein can be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the various features in the disclosed embodiments of the present invention can be combined with each other in any way. The reason for not exhaustively describing the situations of these combinations in this specification is only to save space and resources. Therefore, the present invention is not limited to the specific embodiments disclosed in the text, but includes all technical solutions falling within the scope of the claims.

Claims

1. A solid water-soluble hand sanitizer, characterized in that: Including basic raw materials and functional ingredients in accordance with the specific proportion of the formula, among which, The basic raw material is made of the following components by weight: 10% to 50% of a moisturizing shaping agent, 5% to 20% of a foaming agent, 0.5% to 2% of a preservative, and 0.5% to 1% of a fragrance; The active ingredient raw materials are made of the following ingredients in parts by weight: 0.1% to 1% of phosphorylcholine polymer, 1% to 10% of betaine, 0.2% to 2% of salicylic acid, 0.1% to 1% of purslane extract, 0.1% to 1% of scutellaria root extract, 0.1% to 1% of Centella asiatica extract, 0.1% to 1% of white willow bark extract, 0.1% to 1% of sorbic acid, and 0.1% to 1% of citric acid.

2. A solid water-soluble hand sanitizer according to claim 1, characterized in that: The phosphorylcholine polymer is one of polyquaternium-51 and polyquaternium-61.

3. A solid water-soluble hand sanitizer according to claim 1, characterized in that: The moisturizing forming agent in the basic raw materials includes sorbitol and urea raw materials in a specific proportion according to the formula, wherein sorbitol accounts for 10% to 50% and urea accounts for 10% to 50%.

4. A solid water-soluble hand sanitizer according to claim 1, characterized in that: The preservative in the basic raw material is sodium benzoate, accounting for 0.5% to 2%, and the aromatic agent in the basic raw material is essence, accounting for 0.5% to 1%.

5. A solid water-soluble hand sanitizer according to claim 1, characterized in that: The foaming agent in the basic raw material is one or a mixture of sodium methyl cocoyl taurate, sodium lauroyl glutamate, and sodium lauryl sulfate, wherein sodium methyl cocoyl taurate is 5% to 20%, sodium lauroyl glutamate is 5% to 20%, and sodium lauryl sulfate is 5% to 20%.

6. A solid water-soluble hand sanitizer according to claim 1, characterized in that: The extraction steps of the purslane extract, scutellaria root extract, Centella asiatica extract and willow bark extract are as follows: purslane, scutellaria root, Centella asiatica and willow bark are cleaned and put into a grinder for grinding respectively, and then screened and purified through a 80-120 mesh sieve to finally obtain the finished purslane extract, scutellaria root extract, Centella asiatica extract and willow bark extract.

7. A method for preparing a solid water-soluble hand sanitizer as claimed in any one of claims 1 to 6, characterized in that: The following steps are involved: A. Weigh each raw material according to the proportion of each raw material by mass, place sorbitol, urea, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium lauryl sulfate, phosphorylcholine polymer, purslane extract, scutellaria root extract, Centella asiatica extract, and white willow bark extract in a 55° C. oven, dry for 24 hours, place in a stirring pot, and stir and mix; B. Place the dried raw materials in step A and the undried sodium benzoate, flavor, betaine, salicylic acid, sorbic acid, and citric acid in a stirring pot and stir and disperse them fully, and take samples for pH value detection, the pH value is 5.5-6.5; C. Transfer the mixed raw materials qualified by pH test in step B to a tablet press for tableting, and compress the powder mixture at a unit area pressure of 35-50 kg / cm2 to obtain a preformed block; D. Send the preformed blocks to a dehumidification room, dehumidify and package them under the conditions of temperature 20-25°C and humidity 20%-40%RH to obtain solid water-soluble hand sanitizer.

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